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Ana Margarida Moutinho Grenha is Associate Professor at the Universidade do Algarve - Faculdade de Ciências e Tecnologia, and researcher at the Centre for Marine Sciences (CCMAR). She received the Habilitation in Pharmacy - Pharmaceutical Technology in July 2022. She has published 50 research papers in peer-reviewed journals mainly in the area of Pharmaceutics/Drug Delivery and Materials Science, has published 9 book chapters and served as Guest Editor of two special issues. She authored 1 patent and has one patent pending (EPO submission). Has experience as coordinator and participant of research projects with competitive funding at national level, as well as experience in student supervision, 4 PhD students concluded, 2 PhD students ongoing (1 of them as co-supervisor) and 15 MSc students concluded. She was awarded the prize "Investigador Universidade do Algarve 2022", and the "Prémio Robalo Cordeiro Sociedade Portuguesa de Pneumologia" in 2020. She acts in the field of Health Sciences, with emphasis on Pharmaceutical Technology - Drug Delivery. In her Ciência Vitae CV the most frequent words in the context of scientific outputs are: Lung delivery; Pulmonary delivery; Drug delivery; Microparticles; Inhalable carriers; Nanoparticles; Spray-drying; Drug targeting; Polysaccharides.
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Identification

Personal identification

Full name
Ana Margarida Moutinho Grenha

Citation names

  • Grenha, Ana

Author identifiers

Ciência ID
091C-0D58-7225
ORCID iD
0000-0002-2136-1396

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Upper intermediate (B2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2022/07
Concluded
 Agregação em Farmácia - Tecnologia Farmacêutica (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007/02/01 - 2007/08/31
Concluded
 Grupo 3Bs (Pós-doutoramento)
Universidade do Minho Departamento de Engenharia de Polímeros, Portugal
2002/11 - 2007/01
Concluded
 Investigación y desarrollo de medicamentos (Doutoramento)
Major in Farmacia y Tecnología Farmacéutica
Universidade de Santiago de Compostela - Faculdade de Farmácia, Spain
"Microencapsulation of chitosan nanoparticles for the pulmonary delivery of therapeutic macromolecules" (THESIS/DISSERTATION)
 Sobresaliente cum laude
2002 - 2004
Concluded
 Farmacia (DEA)
Universidade de Santiago de Compostela - Faculdade de Farmácia, Spain
 Sobresaliente
1997 - 2001
Concluded
 Farmácia (Licenciatura)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
 16 valores
Affiliation

Science

Category
Host institution 		Employer
2017/07 - Current Principal Investigator (Research) Centro de Ciências do Mar, Portugal
Universidade do Algarve, Portugal
2008/01 - 2017/06 Principal Investigator (Research) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Universidade do Algarve, Portugal
2002/11 - 2007/01 Researcher (Research) Universidade de Santiago de Compostela - Faculdade de Farmácia, Spain
2005/09 - 2005/12 Research Trainee (Research) King's College London Department of Pharmacy, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2023/07/01 - Current Associate Professor (University Teacher) Universidade do Algarve, Portugal
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2009/01/01 - 2023/06/30 Assistant Professor (University Teacher) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2007/09/01 - 2008/12/31 Adjunct Teacher (Polytechnic Teacher) Universidade do Algarve, Portugal
Universidade do Algarve Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2021/01/01 - Current Collaborator at iMed.ULisboa Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2020/01 - 2020/01 Visiting Researcher at University of Santiago de Compostela Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Spain
2018/06 - 2018/06 Visiting researcher at University of Perugia Università degli Studi di Perugia, Italy
2017/06 - 2017/06 Visiting Researcher at University of Lyon Université Claude Bernard Lyon 1, France
2016/11 - 2016/11 Visiting Researcher at University of Parma Università degli Studi di Parma Dipartimento di Scienze degli Alimenti e del Farmaco, Italy
2013/09 - 2013/09 Visiting Researcher at University of Santiago de Compostela Universidade de Santiago de Compostela Departamento de Farmacoloxía Farmacia e Tecnoloxía Farmacéutica, Spain
Projects

Contract

Designation Funders
2023/01/01 - 2025/12/31 CRUCITECNO-ECOL: Desarrollo y caracterización de alimentos funcionales obtenidos a partir de crucíferas cultivadas en condiciones ecológicas y nuevas tecnologias de processado
ProyExcel_00789
Researcher
Universidad de Córdoba, Spain
Ongoing
2023/01/01 - 2025/12/31 Metabolitos secundários en Brassicaceae: Implicaciones en la mejora genética y defensa a estreses
PID2021-126472OB-I00
Researcher
Agencia Estatal Consejo Superior de Investigaciones Científicas, Spain
Ongoing
2022/04/01 - 2024/03/31 GERMROS: The imprinting characteristics of spermatogonia antioxidant capacity and their role in oxidative stress tolerance
EXPL/CVT-CVT/0305/2021
Researcher
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/04/01 - 2023/03/31 NUTRISAFE - Exploring a novel and sustainable sea-based diet supplement to promote longevity and quality of life in a pandemic era
nº 72583, referência 10ID00164
Researcher
Centro de Ciências do Mar, Portugal

Universidade do Algarve, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Algarve
Concluded
2019/01 - 2021/12 NANOSPEED - Nanoencapsulation of drugs using biopolymers with specific abilities for drug delivery
-
Principal investigator
Centro de Ciências do Mar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/04/01 - 2015/12/31 Fighting TB: Development of microparticulate systems for alveolar macrophage targeting in tuberculosis therapy
PTDC/DTP-FTO/0094/2012
Principal investigator
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/01 - 2014/12 ZEBRAFEEDS - Development of reference diets for the padronisation of zebra fish nutrition in biomedical studies
Projeto 23000
Researcher
Centro de Ciências do Mar, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Algarve
Concluded
2011/01 - 2013/12 miPS and hiPS - Reprogramming mice and human adult cells
PTDC/SAU-ENB/111702/2009
Researcher
Universidade do Algarve, Portugal
Concluded
2010/01 - 2013/12 NanoPulmoGen - Sistemas nanotransportadores microencapsulados para liberación pulmonar de material genético
-
Other
Universidade de Santiago de Compostela - Faculdade de Farmácia, Spain
 Gobierno de España
Concluded
2010/01/01 - 2013/07 Development of non-viral vectors for ocular gene therapy
PTDC/SAU-BEB/098475/2008
Researcher
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 EncapsDevice – Development of polymeric nanosctructures for nasal and pulmonary delivery of peptides and proteins
PTDC/SAU-FCF/100291/2008
Principal investigator
Universidade do Algarve, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/09/01 - 2013/01/31 MICALA - Development of a microencapsulated feed for fish larvae
Projeto 13380
Principal investigator
Universidade do Algarve, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluded
2010/01 - 2012/12 Nanotransportadores microencapsulados para administración pulmonar de material genético
-
Other
Universidade de Santiago de Compostela - Faculdade de Farmácia, Spain
 Xunta de Galicia
Concluded
Outputs

Publications

Book chapter
  1. M Fonseca; A Macedo; Pontes, JF; Grenha, Ana; Fonte, Pedro. "New and revisited approaches on the transdermal delivery of polyphenols-loaded nanoparticles for melanoma prevention and treatment". In Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products. 2023.
    Published
  2. Greque Morais, Etiele; Pontes, JF; Grenha, Ana; Varela, Joao; Barreira, Luísa. "Microalgae applications in nanotechnology: an outstanding tool for nanocompounds synthesis and bioproducts obtention". Apple Academic Press/CRC Press, 2022.
    Published
  3. Grenha, Ana; Bebianno, MJ; Rocha, TL; Pontes, JF; Amaral, AC. "Potential ecotoxicological risk of nanopharmaceuticals in the aquatic environment". In Environmental Impact of Nanopharmaceuticals, 289-317. Springer, 2021.
    Published
  4. Grenha, Ana; Noelia Flórez-Fernández; Maria Dolores Torres; Luis Braz; EP Loret; Herminia Domínguez. "Seaweed and Sea Anemones Proteins as a Source of New Pharmaceutical Active Principles". In Marine Niche: Applications in Pharmaceutical Sciences, 203-219. Springer Singapore, 2020.
    Published
  5. Almeida, A.J.; Grenha, A.. "Technosphere®: An inhalation system for pulmonary delivery of biopharmaceuticals". In Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. 2014.
    10.1007/978-1-4614-9524-6_22
  6. Grenha, Ana. "Chitosan-based systems for biopharmaceuticals mucosal delivery". In Chitosan-based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics. New York, United States: John Wiley and Sons, 2012.
    Published
  7. Braz, L.; Dionísio, M.; Grenha, A.. "Chitosan-based nanocarriers: Effective vehicles for mucosal protein delivery". In Chitosan-based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics. 2011.
  8. Braz, L.; Rodrigues, S.; Fonte, P.; Grenha, A.; Sarmento, B.. "Mechanisms of chemical and enzymatic chitosan biodegradability and its application on drug delivery". In Biodegradable Polymers: Processing, Degradation and Applications. 2011.
Conference paper
  1. Pontes, Jorge F.; Diogo, Hermínio; Conceição, Eusébio; Musacchio, Flavia; Borges dos Santos, Rui M.; Grenha, Ana. "Development of a prototype of an aerosolization device for dry powders to improve in vitro cell-based assays in the context of lung delivery". Paper presented in Drug Delivery to the Lungs 2021, 2021.
  2. Pontes, JF; Duarte, Emanuel; Flórez-Fernández, Noelia; Rico, João André Martins; Cruz Silva, Joana; Lollo, G; Domínguez, Herminia; Grenha, Ana. "Fucoidan-coated lipid nanocapsules encapsulating a model drug for lung drug delivery". Paper presented in Drug Delivery to the Lungs - DDL 2020, 2020.
    Published
  3. Jorge F. Pontes; Luis Braz; Filipa Guerreiro; Ana M. Rosa da Costa; Grenha, Ana; Giovanna Lollo; Eyad Almouazen. "Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers". Paper presented in Drug Delivery to the Lungs - DDL 2019, 2019.
    Published
  4. Filipa Guerreiro; Magda Swedrowska; AM Rosa da Costa; Ben Forbes; Grenha, Ana. "In vitro behaviour of konjac glucomannan microparticles aimed at pulmonary tuberculosis therapy". Paper presented in Drug Delivery to the Lungs - DDL 2019, 2019.
    Published
  5. Filipa Guerreiro; Ana M. Rosa da Costa; M. Leonor Faleiro; Grenha, Ana. "Konjac glucomannan microparticles for antitubercular drug delivery by inhalation". Paper presented in Drug Delivery to the Lungs, Edinburgh, 2017.
    Published
  6. Susana Rodrigues; Francesca Buttini; Lea Ann Dailey; ML Faleiro; AM Rosa da Costa; Grenha, Ana. "Chondroitin sulphate microparticles as antitubercular drug carriers". Paper presented in Drug Delivery to the Lungs - DDL2017, Edinburgh, 2017.
    Published
  7. Cunha, Ludmylla Costa; Rosa da Costa, AM; Grenha, Ana. "Inhalable chitosan microparticles as tools in tuberculosis therapy". Paper presented in Drug Delivery to the Lungs - DDL2016, Edimburgh, 2016.
  8. Musacchio, Flavia; Grenha, Ana. "Dextran sulfate microparticles encapsulating isoniazid and/or rifabutin as carriers for pulmonary tuberculosis therapy". Paper presented in Drug Delivery to the Lungs - DDL2016, Edimburgh, 2016.
    Published
  9. Rodrigues, Susana; Rosa da Costa, AM; Grenha, Ana. "Chondroitin sulphate microparticles for tuberculosis treatment: A way to target macrophages". Paper presented in Drug Delivery to the Lungs - DDL2016, 2016.
Conference poster
  1. Grenha, Ana; Pinto-da-Silva, Joana; Pérez-Rodríguez, F; Almeida, MP; Cámara-Martos, F. "Microencapsulation of benzyl - isothiocyanate by spray-drying as a tool to improve bioaccessibility in white mustard (Sinapis alba)". Paper presented in 8th International Conference on Food Digestion, 2024.
  2. Viegas, Claudia; Grenha, Ana; Fonte, Pedro. "Enhancing lung cancer therapy through inhalable microparticles containing antibody loaded mPEG-PLGA nanoparticles". Paper presented in Pulmonary Drug Delivery Workshop (PDD), 2024.
  3. Pinto-da-Silva, Joana; Figueiras, Ana; Grenha, Ana. "Pulmonary delivery of bacterial lysates mediated by locust bean gum microparticles". Paper presented in Pulmonary Drug Delivery Workshop (PDD), 2024.
  4. Viegas, Claudia; Duarte, S; Grenha, Ana; Fonte, Pedro. "Microparticles containing antibody loaded mPEG-PLGA nanoparticles for lung cancer treatment by inhalation". Paper presented in XV Spanish-Portuguese Conference on Controlled Drug Delivery, 2024.
  5. Pinto-da-Silva, Joana; Figueiras, Ana; Grenha, Ana. "Non-toxic mucoadhesive locust bean gum microparticles for delivery of bacterial lysates to prevent respiratory diseases". Paper presented in XV Spanish-Portuguese Conference on Controlled Drug Delivery, 2024.
  6. Viegas, Claudia; Duarte, S; Lourenço, JP; Grenha, Ana; Fonte, Pedro. "Formulations of antibody-loaded mPEG-PLGA nanoparticles dry powder for inhalation for lung cancer treatment". Paper presented in X Congreso Iberoamericano de Ciencias Farmacéuticas, 2023.
  7. Pinto-da-Silva, Joana; Braz, Luis; Grenha, Ana. "New dry powder aerosolization device designed for in vitro applications - Validation tests". Paper presented in X Congreso Iberoamericano de Ciencias Farmacéuticas, 2023.
  8. Setas, S; Pinto-da-Silva, Joana; Oliveira, M; Grenha, Ana; Barreira, Luísa; Serralheiro, Ana. "Avaliação da citotoxicidade de extratos de uma microalga marinha num modelo celular de cancro colorretal". Paper presented in X Congreso Iberoamericano de Ciencias Farmacéuticas, 2023.
  9. Nuc, Zofia; Brusotti, Gloria; Moro, P.; Grenha, Ana; Guerreiro, Filipa; Catenacci, L.; Milanese, C.; et al. "Crustaceans from Polish waters as alternative sources of chitin and chitosan". Paper presented in 14th International Conference of the European Chitin Society (EUCHIS 2023), 2023.
  10. C Viegas; Lourenço JP; Grenha, Ana; Fonte, Pedro. "Microencapsulation of mPEG-PLGA nanoparticles for potential inhalable anticancer therapy". Paper presented in DDL32-2022 Drug Delivery to the Lungs, 2022.
  11. Pinto-da-Silva, Joana; Cruz Silva, Joana; Grenha, Ana. "Locust bean gum microparticles as carriers for lung delivery of bacterial lysates". Paper presented in DDL32-2022 Drug Delivery to the Lungs, 2022.
  12. Fernando Camara Martos; Filipa Guerreiro; JA Lopes; Grenha, Ana. "Microencapsulation of selenium by spray-drying as a tool to improve bioaccessibility in food matrix". Paper presented in 7th International Conference on Food Digestion, 2022.
  13. Pinto-da-Silva, Joana; Cruz Silva, Joana; Grenha, Ana. "Development of an inhalable formulation of bacterial lysates for application in the context of respiratory infections". Paper presented in 8th Galenus International Conference, 2022.
  14. Grenha, Ana; Flórez-Fernández, Noelia; Afonso, Carolina; Guerreiro, Filipa Raquel Horta; Pontes, Jorge Filipe Rodrigues; Torres, MD; Domínguez, Herminia. "Antiproliferative effect of the extracts obtained from Himanthalia elongata and their ability to produce polymeric nanoparticles". Paper presented in CINBIO Conference, 2021.
  15. Flórez-Fernández, Noelia; Álvarez-Viñas, M; Torres, MD; Domínguez, Herminia; Grenha, Ana. "Exploring the ability to produce polymeric nanoparticles using extracts obtained from Chondrus crispus". Paper presented in Seaweed for Health, 2021.
  16. Grenha, Ana; Noelia Flórez-Fernández; Maria Dolores Torres; Domínguez, Herminia. "Formulation of polymeric nanoparticles using a bioactive extract of the invasive brown seaweed Sargassum muticum". Paper presented in 1st Greenering International Conference (virtual format), 2021.
  17. Grenha, Ana; Jorge F. Pontes; Emanuel Duarte; Flórez-Fernández, Noelia; Joao Rico; Joana Cruz; Giovanna Lollo; Domínguez, Herminia. "Fucoidan-coated lipid nanocapsules encapsulating a model drug for lung drug delivery". Paper presented in Drug Delivery to the Lungs Christmas Lectures (virtual format), 2020.
  18. Guerreiro, Filipa Raquel Horta; Swedrowska, M; Rosa da Costa, Ana M.; Forbes, Ben; Grenha, Ana. "Aerodynamic characterisation of konjac glucomannan microcarriers targeted to the alveolar region through inhalation". Paper presented in Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  19. Pontes, Jorge Filipe Rodrigues; Braz, Luis; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna; Grenha, Ana. "Stability evaluation of sulphated locust bean gum-coated lipid nanocapsules". Paper presented in Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  20. Flórez-Fernández, Noelia; Pontes, Jorge F.; Domínguez, Herminia; Grenha, Ana. "Evaluation of nanosystems based on biopolymers: Fucoidan from the edible brown seaweed Laminaria japonica and chitosan". Paper presented in Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  21. Pontes, Jorge Filipe Rodrigues; Braz, Luis; Guerreiro, Filipa Raquel Horta; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna; Grenha, Ana. "Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carrier". Paper presented in DDL30-2019 Drug Delivery to the Lungs Conference, 2019.
    10.2118/198789-ms
  22. Guerreiro, Filipa Raquel Horta; Swedrowska, M; Rosa da Costa, Ana M; Grenha, Ana; Forbes, Ben. "Konjac glucomannan-based microcarriers to target macrophage". Paper presented in DDL30-2019 Drug Delivery to the Lungs Conference, 2019.
  23. Grenha, Ana; Pontes, Jorge F.; Braz, Luis; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna. "Development of nanocapsules using a locust bean gum sulfate derivative". Paper presented in 22nd International Symposium on Microencapsulation, 2019.
  24. Braz, Luis; Raimundo, Pedro; Rosa da Costa, Ana M; Grenha, Ana. "Locust Bean Gum-only nanoparticles for mucosal protein delivery". Paper presented in CRS Annual Meeeting and Exposition, 2018.
  25. Pontes, Jorge F.; Cordeiro, Clara; Grenha, Ana. "Design of experiments to study the stability of chitosan/dextran sulfate (CS/DS) nanoparticles". Paper presented in CRS Annual Meeting and Exposition, 2018.
  26. Guerreiro, Filipa Raquel Horta; Rosa da Costa, Ana M; Faleiro, Maria Leonor; Grenha, Ana. "Uptake of konjac glucomannan microparticles by macrophage-like cells for an application in tuberculosis therapy". Paper presented in CRS Annual Meeting and Exposition, 2018.
  27. Guerreiro, Filipa; Rosa da Costa, AM; Faleiro, ML; Grenha, Ana. "Konjac glucomannan-based microcarriers to target macrophages". Paper presented in DDL28-2017 Drug Delivery to the Lungs Conference, 2017.
  28. Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. "Chondroitin sulphate microparticles: Application in macrophage targeting for tuberculosis treatment". Paper presented in DDL28-2017 Drug Delivery to the Lungs Conference, 2017.
  29. Araújo, Nuna; Viegas, CSB; Pontes, JF; Magalhães, J; Blanco, FJ; Macedo, AL; Grenha, Ana; Simes, DC. "Nano-encapsulation of GLA-rich protein (GRP) and potential added value as a therapeutic agent for osteoarthritis". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  30. Gaspar, MM; Nave, M; Simões, Sandra; Almeida, AJ; Alves, AB; Grenha, Ana. ". Improved therapeutic effect of rifabutin/isoniazid microparticles for the treatment of tuberculosis following pulmonary administration". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  31. Grenha, Ana; Pontes, JF; Cordeiro, C. "Chitosan/dextran sulfate (CS/DS) nanoparticles: Stability evaluation using factorial design". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  32. Musacchio, Flavia; Guerreiro, Filipa; Cruz, Rui; Grenha, Ana. "Spray-drying optimization to produce xanthan gum microparticles". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  33. Guerreiro, Filipa; Rosa da Costa, AM; Faleiro, ML; Grenha, A.. "Cytotoxic evaluation and macrophage activation ability of konjac glucomannan microparticles". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  34. Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. "Starch/carrageenan microparticles for lung delivery of antitubercular drugs". Paper presented in 21st International Symposium on Microencapsulation, 2017.
  35. Cunha, Ludmylla Costa; Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. "Inhalable fucoidan microparticles as tool in tuberculosis therapy". Paper presented in 21st International Symposium on Microencapsulation, 2017.
Journal article
  1. Pontes, Jorge F.; Diogo, HP; Conceição, E.; Almeida, M.P.; Borges dos Santos, R.M.; Grenha, A.. "Development of a dry powder insufflation device with application in in vitro cell-based assays in the context of respiratory delivery". European Journal of Pharmaceutical Sciences (2024):
    Accepted
  2. Guerreiro, Filipa; Pontes, Jorge F.; Gaspar, Maria Manuela; Rosa da Costa, Ana M.; Faleiro, Maria Leonor; Grenha, Ana. "Respirable konjac glucomannan microparticles as antitubercular drug carriers: Effects of in vitro and in vivo interactions". International Journal of Biological Macromolecules 248 (2023): 125838. http://dx.doi.org/10.1016/j.ijbiomac.2023.125838.
    Published • 10.1016/j.ijbiomac.2023.125838
  3. Grenha, Ana; F Guerreiro; Lourenço JP; JA Lopes; F Cámara Martos. "Microencapsulation of selenium by spray-drying as a tool to improve bioaccessibility in food matrix". Food Chemistry 402 (2023): 134463.
    Published
  4. Flórez-Fernández, Noelia; Pontes, JF; F Guerreiro; I Afonso; Giovanna Lollo; Torres, MD; Domínguez, Herminia; AM Rosa da Costa; Grenha, Ana. "Fucoidan from Fucus vesiculosus: Evaluation of the impact of the sulphate content on nanoparticle production and cell toxicity". Marine Drugs 21 (2023): 115.
    Published
  5. Nuc, Zofia; Brusotti, Gloria; Catenacci, Laura; Grenha, Ana; Pontes, Jorge F.; Pinto da Silva, Joana; Rosa da Costa, Ana Maria; et al. "Pontastacus leptodactylus (Eschscholtz, 1823) and Faxonius limosus (Rafinesque, 1817) as New, Alternative Sources of Chitin and Chitosan". Water 15 17 (2023): 3024. http://dx.doi.org/10.3390/w15173024.
    Published • 10.3390/w15173024
  6. Viegas, CSB; Araújo, Nuna; J Carreira; Pontes, JF; LM Anjos; Vinhas, Maurícia; AS Moreira; et al. "Nanoencapsulation of Gla-rich protein (GRP) as a novel approach to target inflammation". International Journal of Molecular Sciences 23 (2022): 4813.
    Published
  7. Susana Rodrigues; Ludmylla Cunha; Julia Kollan; Paul Robert Neumann; Ana M. Rosa da Costa; Lea Ann Dailey; Grenha, Ana. "Cytocompatibility and cellular interactions of chondroitin sulfate microparticles designed for inhaled tuberculosis treatment". European Journal of Pharmaceutics and Biopharmaceutics 163 (2021): 171-178.
    Published
  8. Annalisa Rosso; Yves Chevalier; Jacqueline Sidi-Boumedine; Grenha, Ana; Filipa Guerreiro; Adem Gharsallaoui; Veronica La Padula; et al. "Nanocomposite sponges for enhancing intestinal residence time following oral administration". Journal of Controlled Release 333 (2021): 579-592.
    Published
  9. Guerreiro, Filipa Raquel Horta; Swedrowska, Magda; Patel, R; Flórez-Fernández, Noelia; Torres, MD; Rosa da Costa, AM; Forbes, Ben; Grenha, Ana. "Engineering of konjac glucomannan into respirable microparticles for delivery of antitubercular drugs". International Journal of Pharmaceutics 604 (2021): 120731.
    Published
  10. Noelia Flórez-Fernández; Milena Álvarez-Viñas; Filipa Guerreiro; María Dolores Torres; Ana Grenha; Herminia Domínguez. "Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles". Marine Drugs 18 7 (2020): 336-336. https://doi.org/10.3390/md18070336.
    10.3390/md18070336
  11. Susana Rodrigues; Ludmylla Cunha; João Rico; Ana M. Rosa da Costa; António J. Almeida; M. Leonor Faleiro; Francesca Buttini; Ana Grenha. "Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages". Drug Delivery and Translational Research (2020): https://doi.org/10.1007/s13346-020-00799-0.
    10.1007/s13346-020-00799-0
  12. Rodrigues; da Costa; Flórez-Fernández; Torres; Faleiro; Buttini; Grenha. "Inhalable Spray-Dried Chondroitin Sulphate Microparticles: Effect of Different Solvents on Particle Properties and Drug Activity". Polymers 12 2 (2020): 425. http://dx.doi.org/10.3390/polym12020425.
    10.3390/polym12020425
  13. Grenha, Ana; Alves, Ana D.; Guerreiro, Filipa; Pinho, Jacinta; Simões, Sandra; Almeida, António José; Gaspar, Maria Manuela. "Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin: Therapeutic assessment in a murine model of tuberculosis infection". European Journal of Pharmaceutics and Biopharmaceutics 147 (2020): 38-44. http://dx.doi.org/10.1016/j.ejpb.2019.11.009.
    10.1016/j.ejpb.2019.11.009
  14. Pontes; Grenha. "Multifunctional Nanocarriers for Lung Drug Delivery". Nanomaterials 10 2 (2020): 183. http://dx.doi.org/10.3390/nano10020183.
    10.3390/nano10020183
  15. Cunha, Ludmylla; Rodrigues, Susana; Rosa da Costa, Ana M.; Faleiro, Leonor; Buttini, Francesca; Grenha, Ana. "Inhalable chitosan microparticles for simultaneous delivery of isoniazid and rifabutin in lung tuberculosis treatment". Drug Development and Industrial Pharmacy 45 8 (2019): 1313-1320. http://dx.doi.org/10.1080/03639045.2019.1608231.
    10.1080/03639045.2019.1608231
  16. Guerreiro, Filipa; Pontes, Jorge F.; Rosa da Costa, Ana M.; Grenha, Ana. "Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers". Powder Technology 342 (2019): 246-252. http://dx.doi.org/10.1016/j.powtec.2018.09.068.
    10.1016/j.powtec.2018.09.068
  17. Cunha, Ludmylla; Rodrigues, Susana; Rosa da Costa, Ana; Faleiro, M; Buttini, Francesca; Grenha, Ana. "Inhalable Fucoidan Microparticles Combining Two Antitubercular Drugs with Potential Application in Pulmonary Tuberculosis Therapy". Polymers 10 6 (2018): 636. http://dx.doi.org/10.3390/polym10060636.
    10.3390/polym10060636
  18. Cunha, Ludmylla; Rosa da Costa, Ana M.; Lourenço, João P.; Buttini, Francesca; Grenha, Ana. "Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs". Journal of Microencapsulation 35 4 (2018): 392-405. http://dx.doi.org/10.1080/02652048.2018.1513089.
    10.1080/02652048.2018.1513089
  19. Roberto, V. P.; Martins, G.; Pereira, A.; Rodrigues, S.; Grenha, A.; Pinto, W.; Cancela, M. L.; Dias, J.; Gavaia, P. J.. "Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers". Journal of Applied Ichthyology 34 2 (2018): 512-523. http://dx.doi.org/10.1111/jai.13664.
    10.1111/jai.13664
  20. Braz, Luis; Grenha, Ana; Corvo, Marta C.; Lourenço, João Paulo; Ferreira, Domingos; Sarmento, Bruno; Rosa da Costa, Ana M.. "Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles". Carbohydrate Polymers 181 (2018): 974-985. http://dx.doi.org/10.1016/j.carbpol.2017.11.052.
    10.1016/j.carbpol.2017.11.052
  21. Grenha, Ana. "Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery.". Molecular pharmaceutics 14 9 (2017): 2977-2990. http://europepmc.org/abstract/med/28809501.
    10.1021/acs.molpharmaceut.7b00169
  22. Grenha, Ana. "Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles.". International journal of pharmaceutics 529 1-2 (2017): 433-441. http://europepmc.org/abstract/med/28669623.
    10.1016/j.ijpharm.2017.06.088
  23. Braz L; Grenha A; Ferreira D; Rosa da Costa AM; Gamazo C; Sarmento B. "Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization.". International Journal of Biological Macromolecules 96 (2017): 786-797. http://europepmc.org/abstract/med/28049014.
    10.1016/j.ijbiomac.2016.12.076
  24. Ana Alves; Joana Cavaco; Filipa Guerreiro; João Lourenço; Ana Rosa da Costa; Ana Grenha. "Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles". Molecules 21 6 (2016): 702-702. https://doi.org/10.3390/molecules21060702.
    10.3390/molecules21060702
  25. Dionísio M; Braz L; Corvo M; Lourenço JP; Grenha A; Rosa da Costa AM. "Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation.". International Journal of Biological Macromolecules 86 (2016): 129-138. http://europepmc.org/abstract/med/26800902.
    Published • 10.1016/j.ijbiomac.2016.01.054
  26. Cunha L; Grenha A. "Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.". Marine Drugs 14 3 (2016): http://europepmc.org/abstract/med/26927134.
    Open access • Published • 10.3390/md14030042
  27. Susana Rodrigues; Clara Cordeiro; Begoña Seijo; Carmen Remuñán-López; Ana Grenha. "Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation". Carbohydrate Polymers 123 (2015): 369-380. https://doi.org/10.1016/j.carbpol.2015.01.048.
    10.1016/j.carbpol.2015.01.048
  28. Rodrigues, S.; Cardoso, L.; da Costa, A.M.R.; Grenha, A.. "Biocompatibility and stability of polysaccharide polyelectrolyte complexes aimed at respiratory delivery". Materials 8 9 (2015): 5647-5670. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946214588&partnerID=MN8TOARS.
    10.3390/ma8095268
  29. dos Santos MA; Grenha A. "Polysaccharide nanoparticles for protein and Peptide delivery: exploring less-known materials.". Advances in Protein Chemistry and Structural Biology 98 (2015): 223-261. http://europepmc.org/abstract/med/25819281.
    10.1016/bs.apcsb.2014.11.003
  30. Rodrigues S; Grenha A. "Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy.". Current Pharmaceutical Design 21 33 (2015): 4869-4887. http://europepmc.org/abstract/med/26290207.
    Published • 10.2174/1381612821666150820103910
  31. Grenha A. "Editorial: Exploring the Role of Polysaccharides in Drug Delivery.". Current Pharmaceutical Design 21 33 (2015): http://europepmc.org/abstract/med/26333565.
    10.2174/1381612821999150903143853
  32. Perestrelo AR; Grenha A; Rosa da Costa AM; Belo JA. "Locust bean gum as an alternative polymeric coating for embryonic stem cell culture.". Materials Science and Engineering C 40 (2014): 336-344. http://europepmc.org/abstract/med/24857501.
    10.1016/j.msec.2014.04.022
  33. Nunes, R.; Rodrigues, S.; Pasko, P.; Tyszka-Czochara, M.; Grenha, A.; De Carvalho, I.S.. "Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection". Industrial Crops and Products 52 (2014): 99-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887707241&partnerID=MN8TOARS.
    10.1016/j.indcrop.2013.10.015
  34. Grenha A; Rodrigues S. "Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery.". Therapeutic Delivery 4 11 (2013): http://europepmc.org/abstract/med/24228983.
    10.4155/tde.13.99
  35. Costa, H.; Grenha, A.. "Natural carriers for application in tuberculosis treatment". Journal of Microencapsulation 30 3 (2013): 295-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875835304&partnerID=MN8TOARS.
    10.3109/02652048.2012.726283
  36. Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. "Chitosan and its derivatives as nanocarriers for siRNA delivery". Journal of Drug Delivery Science and Technology 22 1 (2012): 29-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857405019&partnerID=MN8TOARS.
    10.1016/S1773-2247(12)50003-1
  37. Grenha, A.. "Chitosan nanoparticles: A survey of preparation methods". Journal of Drug Targeting 20 4 (2012): 291-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859545586&partnerID=MN8TOARS.
    10.3109/1061186X.2011.654121
  38. Rodrigues, S.; Costa, A.M.R.D.; Grenha, A.. "Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios". Carbohydrate Polymers 89 1 (2012): 282-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860214162&partnerID=MN8TOARS.
    10.1016/j.carbpol.2012.03.010
  39. Dionísio, M.; Grenha, A.. "Locust bean gum: Exploring its potential for biopharmaceutical applications". Journal of Pharmacy and Bioallied Sciences 4 3 (2012): 175-185. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864709562&partnerID=MN8TOARS.
    10.4103/0975-7406.99013
  40. Rodrigues S; Dionísio M; López CR; Grenha A. "Biocompatibility of chitosan carriers with application in drug delivery.". Journal of Functional Biomaterials 3 (2012): 615-641. http://europepmc.org/abstract/med/24955636.
    Published • 10.3390/jfb3030615
  41. Al-Qadi, S.; Grenha, A.; Carrión-Recio, D.; Seijo, B.; Remuñán-López, C.. "Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations". Journal of Controlled Release 157 3 (2012): 383-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857357652&partnerID=MN8TOARS.
    10.1016/j.jconrel.2011.08.008
  42. Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. "Chitosan-Based Systems for Mucosal Delivery of Biopharmaceuticals". Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics (2012): 181-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885525409&partnerID=MN8TOARS.
    10.1002/9781119962977.ch11
  43. Grenha, A.. "Systemic delivery of biopharmaceuticals: Parenteral forever?". Journal of Pharmacy and Bioallied Sciences 4 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859738417&partnerID=MN8TOARS.
    10.4103/0975-7406.94807
  44. Grenha, A.. "The era of nanomedicine". Journal of Pharmacy and Bioallied Sciences 3 2 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79957564241&partnerID=MN8TOARS.
    10.4103/0975-7406.80757
  45. Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. "Microspheres loaded with polysaccharide nanoparticles for pulmonary delivery: Preparation, structure and surface analysis". Carbohydrate Polymers 86 1 (2011): 25-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959328996&partnerID=MN8TOARS.
    10.1016/j.carbpol.2011.03.022
  46. Grenha, A.; Al-Qadi, S.; Seijo, B.; Remuñán-López, C.. "The potential of chitosan for pulmonary drug delivery". Journal of Drug Delivery Science and Technology 20 1 (2010): 33-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749099834&partnerID=MN8TOARS.
    10.1016/S1773-2247(10)50004-2
  47. Grenha, A.; Gomes, M.E.; Rodrigues, M.; Santo, V.E.; Mano, J.F.; Neves, N.M.; Reis, R.L.. "Development of new chitosan/carrageenan nanoparticles for drug delivery applications". Journal of Biomedical Materials Research - Part A 92 4 (2010): 1265-1272. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349114274&partnerID=MN8TOARS.
    10.1002/jbm.a.32466
  48. Carvalho, E.L.S.; Grenha, A.; Remuñán-López, C.; Alonso, M.J.; Seijo, B.. "Chapter 15 Mucosal Delivery of Liposome-Chitosan Nanoparticle Complexes". Methods in Enzymology 465 C (2009): 289-312. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549133048&partnerID=MN8TOARS.
    10.1016/S0076-6879(09)65015-1
  49. Grenha A; Seijo B; Serra C; Remuñán-López C. "Surface characterization of lipid/chitosan nanoparticles assemblies, using X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.". (2008): http://europepmc.org/abstract/med/18468083.
  50. Grenha, A.; Remuñán-López, C.; Carvalho, E.L.S.; Seijo, B.. "Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins". European Journal of Pharmaceutics and Biopharmaceutics 69 1 (2008): 83-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-41549155028&partnerID=MN8TOARS.
    10.1016/j.ejpb.2007.10.017
  51. Grenha, A.; Grainger, C.I.; Dailey, L.A.; Seijo, B.; Martin, G.P.; Remuñán-López, C.; Forbes, B.. "Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro". European Journal of Pharmaceutical Sciences 31 2 (2007): 73-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247475718&partnerID=MN8TOARS.
    10.1016/j.ejps.2007.02.008
  52. Grenha, A.; Seijo, B.; Serra, C.; Remuñán-López, C.. "Chitosan nanoparticle-loaded mannitol microspheres: Structure and surface characterization". Biomacromolecules 8 7 (2007): 2072-2079. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547093165&partnerID=MN8TOARS.
    10.1021/bm061131g
  53. Grenha, A.; Seijo, B.; Remuñán-López, C.. "Microencapsulated chitosan nanoparticles for lung protein delivery". European Journal of Pharmaceutical Sciences 25 4-5 (2005): 427-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-20744434748&partnerID=MN8TOARS.
    10.1016/j.ejps.2005.04.009
Journal issue
  1. Grenha, Ana; Flórez-Fernández, Noelia. "Special issue EUFEPS 2023". European Journal of Pharmaceutical Sciences (2024):
    In press • Invited editor
  2. Grenha, Ana. "Multifunctional Nanocarriers for Drug Delivery". Nanomaterials (2019): https://www.mdpi.com/journal/nanomaterials/special_issues/Nanocarrier_Drug.
    Published • Invited editor
  3. Grenha, Ana. "Exploring the role of polysaccharides in drug delivery". Current Pharmaceutical Design 21 33 (2015): https://www.ingentaconnect.com/content/ben/cpd/2015/00000021/00000033;jsessionid=51gfj8m9v424v.x-ic-live-03.
    Published • Invited editor

Intellectual property

Patent
  1. Ana Grenha; Pontes, JF; RM Borges dos Santos; Eusebio Conceição; Diogo, Hermínio. 2022. "Portable device to study the exposure of cells to dry powders PCT/IB2022/06046". United States.
    Pending
  2. Grenha, Ana; Rodrigues, Susana; Pereira, Filipa; Alves, Ana Bernardina Cotrim Dias; Guerreiro, Filipa. 2022. "Processo para a produção de micropartículas de polissacáridos direcionadas para os macrófagos alveolares, obtenção das micropartículas e uso das mesmas-Patente nacional 116887". Portugal.
    Granted/Issued
  3. Grenha, Ana; Alves,AB; Rodrigues, Susana; Pereira, Filpa; Cunha, Ludmylla Costa; Guerreiro, Filipa. 2016. "Process for producing polysaccharide microparticles for alveolar macrophages targeting, microparticles obtained therein and use thereof WO 2016/174573".
    Pending
Provisional application for patent
  1. 2022. "Inhalable microparticles of bacterial lysates for prevention of respiratory infections".
    Protected
  2. 2021. "Prototype of dry powder aerosolisation device for in vitro assays".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02 Addressing the shortage of excipients approved for inhalation: In vitro and in vivo assessment of the toxicity of polysaccharides Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)
Faculty of Pharmacy University of Lisbon (Lisbon, Portugal)
2023/12 Repurposing bacterial lysates: an inhalation approach for respiratory infection management DDL33-2023 Drug Delivery to the Lungs Conference
The Aerosol Society (Edinburgh, United Kingdom)
2023/10 Repositioning bacterial lysates: inhalation as a strategy in the management of respiratory diseases X Congresso Iberoamericano das Ciências Farmacéuticas
Faculdade de Farmácia - Universidade de Coimbra (Coimbra, Portugal)
2023/03 How did particles come to my life Semana da Bioengenharia - Instituto Superior Técnico
(Portugal)
2022/12 Polysaccharides: Is there an opportunity for application as lung delivery excipients? DDL32-2022 Drug Delivery to the Lungs
(United Kingdom)
2022/07 The potential of inhalation in therapeutics CINBIO Symposium
(Spain)
2021/06/29 Inhalable therapies - Fostering new applications in respiratory disease treatment 8th BiotechHealth Annual Symposium: Biotech Talks - The Future is Now
University of Porto (Porto, Portugal)
2020/12 Konjac glucomannan microcarriers and macrophages: a promising interaction in lung diseases treatment Drug Delivery to the Lungs Christmas Lectures – virtual format
Drug Delivery to the Lungs Conference
2020/11 Terapêutica inalável da tuberculose: Um alinhamento da via de administração do fármaco com a via de infeção / Ihnalable therapy of tuberculosis: Matching the delivery route with the infection route 36º Congresso de Pneumologia
Sociedade Portuguesa de Pneumologia (Albufeira, Portugal)
2019/09 Inhalable therapy of pulmonary tuberculosis mediated by polysaccharide microparticles 22nd International Symposium on Microencapsulation
(Salvador da Bahia, Brazil)
2019/01 Rifabutin formulations with improved therapeutic effect in murine tuberculosis model of infection: Influence of the administration route 14th Spanish Society of Pharmaceutics and Pharmaceutical Technology Meeting
(Santiago de Compostela, Spain)
2018/02 Polysaccharide nanoparticles: Unveiling applications in mucosal drug delivery nanoPT2018 International Conference
(Lisboa, Portugal)
2017/07 Inhalable therapy of pulmonary tuberculosis mediated by polysaccharide microparticles Global Conference on Pharmaceutics and Drug Delivery Systems
(Valencia, Spain)
2017/06 Inhalable dry powders for pulmonary tuberculosis therapy Workshop on Innovative Drug Delivery
Université Lyon 1 (Lyon, France)
2017/06 Inhalable dry powders for pulmonary tuberculosis therapy Workshop on Innovative Drug Delivery
Université Claude Bérnard 1 (Lyon, France)
2012/05 Polysaccharide-based nanoparticles for nasal and pulmonary delivery of biopharmaceuticals II Conference ShareBiotech: New approaches in biopharmaceutical delivery and building networks in biotechnology
(Pamplona, Spain)
2012/02 Polysaccharides as flexible materials for nanoparticles formulation aimed at mucosal protein delivery 2nd World Congress on Pharmaceutics and Novel Drug Delivery Systems
(San Francisco, United States)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/11 - Current Repurposing bacterial lysates as immunomodulators for pulmonary administration as a strategy in prevention of respiratory infections
Supervisor of Joana Pinto da Silva
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2021/01 - Current Antibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment
Co-supervisor of Cláudia Viegas
 Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2021/09 - 2023/12 Polyelectrolyte complexes from chitosan and carrageenan: optimization by Response Surface Methodology and method validation
Co-supervisor of Rahaf Alsayyed
 Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2018/03 - 2023/05 Study of the impact of dry powder insufflation over respiratory epithelial cells
Supervisor of Jorge Filipe Pontes
 Doutoramento em Medicina Regenerativa (PhD)
Universidade do Algarve, Portugal
2021/09 - 2022/12 Avaliação das condições de preparação de complexos polieletrolíticos utilizando extratos ou polímeros com origem marinha
Supervisor of Dinis Rita
 Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2021/09 - 2022/12 Inhalable mannitol microparticles as antigen carriers
Supervisor of Joana Cruz Silva
 Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2020/07 - 2022/12 Unveiling the potential of fucoidan-containing extracts of Laminaria ochroleuca as biomaterial composing the matrix of polyelectrolyte complexes
Supervisor of Carolina Afonso
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2020/09 - 2022/02 Utilizing extracts of Amyloodinium ocellatum in the development of new marine fish therapies
Co-supervisor of António Pedro da Fonseca Jorge Machado Ribeiro
 Aquacultura (Master)
Universidade do Algarve, Portugal
2017/03 - 2021/10 Konjac glucomannan microcarriers: an application in the treatment of pulmonary tuberculosis
Supervisor of Filipa Raquel Horta Guerreiro
 Doutoramento em Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2018/10/01 - 2021/02/28 Application of algae-based biomaterials for the preparation of particulate systems for the mucosal delivery of bioactive substances
Supervisor of Noelia Flórez Fernández (pos-doc)
Centro de Ciências do Mar, Portugal
2019/09 - 2020/12 Synthesis of locust bean gum cationic derivatives for nanoparticles production by polyelectrolyte complexation
Co-supervisor of Miguel Viegas Rodrigues
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2019/09 - 2020/12 Application of experimental design in the preparation of chitosan/carrageenan nanoparticles by polyelectrolytic complexation: Study of the effect of salt addition
Supervisor of Inês Rocheta de Almeida Vasques da Silva
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2014/01 - 2019/12 Development of polysaccharide-based carriers for pulmonary tuberculosis therapy
Supervisor of Susana Isabel Guerreiro Rodrigues
Universidade do Algarve, Portugal
2019/02 - 2019/07 Preparação e caracterização de nanopartículas de Fucoidano e Quitosano formadas por complexação polieletrolítica
Supervisor of Rafaela Silvestre
 Licenciatura em Ciências Biomédicas (Degree)
Universidade do Algarve, Portugal
2013/09 - 2019/02 Nano and microparticles as carriers for alveolar macrophage targeting in pulmonary tuberculosis therapy
Supervisor
 Doutoramento em Ciências Biomédicas (PhD)
Universidade do Algarve, Portugal
2015 - 2016 Chitosan/dextran sulfate nanoparticles: stability evaluation and assessment of the effect of different acidic media on nanoparticle preparation
Supervisor of Jorge Filipe Pontes
 Mestrado Integrado em Ciências Farmacêuticas (Master)
Universidade do Algarve, Portugal
2014 - 2015 Microencapsulation of antitubercular drugs for application in tuberculosis treatment
Supervisor
Universidade Nova de Lisboa, Portugal
2014 - 2015 Spray-dried microparticles aimed at pulmonary delivery of antitubercular drugs
Supervisor
Universidade do Algarve, Portugal
2014 - 2015 Locust bean gum-based microparticles for pulmonary delivery of antibiotics
Supervisor
Universidade do Algarve, Portugal
2013 - 2014 Polymeric microparticles for local pulmonary drug delivery
Supervisor
 Mestrado em Ciências Biomédicas (Master)
Universidade do Algarve, Portugal
2013 - 2014 Development of locust bean gum nanoparticles for protein delivery
Supervisor
Universidade do Algarve, Portugal
2011 - 2012 Encapsulamento de aminoácidos hidrolisados em lipossomas
Supervisor
 Mestrado em Biotecnologia (Master)
Universidade do Algarve, Portugal
2011 - 2012 Desenvolvimento de sistemas nanoparticulados de fucoidan/quitosano para administração de proteínas por vias mucosas
Supervisor
Universidade do Algarve, Portugal
2011/01 - 2011/07 Improving nutrition of fish larvae using innovative microencapsulation techniques
Supervisor of Wilson Pinto (post-doc)
Universidade do Algarve, Portugal
2009 - 2010 Caracterização das propriedades da goma de alfarroba de relevância para aplicação farmacêutica
Supervisor of Marita Dionísio
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/12/06 - 2023/12/08 Organisation of the conference "Drug Delivery to the Lungs: DDL2023" (2023/12/06 - 2023/12/08)
Conference (Member of the Organising Committee)
 The Aerosol Society, United Kingdom
2022/09/01 - 2023/10/28 Participation in Organizing Committee of "X Congresso Iberoamericano de Ciências Farmacêuticas - COIFFA" (2023/10/26 - 2023/10/28) (2023/10/26 - 2023/10/28)
Conference (Member of the Organising Committee)
 Universidade de Coimbra Faculdade de Farmácia, Portugal
2022/09 - 2023/05 Participation in Organizing Committee of "EUFEPS Annual Meeeting 2023" (2023/05/31 - 2023/06/02)
Conference (Member of the Organising Committee)
 The European Federation for Pharmaceutical Sciences, Sweden
2022/01 - 2022/12 Organisation of the conference "Drug Delivery to the Lungs: DDL2022" (2022/12/07 - 2022/12/09)
Conference (Member of the Organising Committee)
 The Aerosol Society, United Kingdom
2020/01/29 - 2020/12/11 Drug Delivery to the Lungs (DDL) Christmas Lectures (2020/12/09 - 2020/12/11)
Conference (Member of the Organising Committee)
 The Aerosol Society, United Kingdom
2019/12/11 - 2019/12/13 Organisation of the conference "Drug Delivery to the Lungs: DDL2019" (2019/12/11 - 2019/12/13)
Conference (Member of the Organising Committee)
 The Aerosol Society, United Kingdom
2017/09/27 - 2017/09/29 Organisation of the 21st International Symposium on Microencapsulation, passed in testimony at the previous conference in Boston (2017/09/27 - 2017/09/29)
Conference (President of the Organising Committee)
 Universidade do Algarve, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/04/05 In vitro evaluation of liposomes tailored for non-invasive delivery of the model antigen ovalbumin to skin, nose and lungs
(Thesis) Main arguer
 Matteo Aroffu (PhD)
2024/02 Análise da Gestão da Manutenção de Equipamentos Médicos do Centro Hospitalar de Setúbal, EPE
(Thesis) Arguer
 Teresa Alexandra Vaz Ferreira (Master) (Master)
Universidade do Algarve Faculdade de Economia, Portugal
2024/01 PARP1 inhibitors for cancer combination therapy: merging liposome encapsulation and UVC irradiation
(Thesis) Main arguer
 Carlota Conceição (PhD) (PhD)
Universidade Nova de Lisboa, Portugal
2024/01 Amorphous solid dispersions for nasal delivery: bridging particle engineering with in vitro and in vivo performance
(Thesis) Main arguer
 Patrícia Dias Henriques (PhD) (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2023/02 Exploração dos recursos genéticos dos Açores para o desenvolvimento de uma enzima com aplicações na saúde: desenvolvimento de uma abordagem direcionada baseada em nanotecnologia (Enzyme4Thrombus)
(Thesis) Main arguer
 Ivo Edgar Araújo Lopes (PhD) (PhD)
Universidade dos Açores, Portugal
2022/09 Aerosoles biocompatibles a partir de polvo seco: Nuevo enfoque en el suministro de fármacos por vía inhalatoria
(Thesis) Main arguer
 Beatriz Arauzo Gimeno (PhD)
Universidad de Zaragoza, Spain
2022/06 A estabilidade dos medicamentos de biotecnologia na farmácia comunitária – o caso da insulina
(Thesis) Main arguer
 Olga Silva (Master)
Universidade do Algarve, Portugal
2022/05 Dissolution of Dry Powder Inhaler formulations: in vitro / in vivo correlations
(Thesis) Arguer
 Beatriz Noriega Fernandes (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/12 Biopharmaceutical formulations for dry powder inhalers
(Thesis) Main arguer
 Diana Alexandra Santana da Silva Fernandes (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/06 Bioaccesibilidad de elementos inorgánicos en leguminosas y potitos ecológicos de base vegetal
President of the jury
 Ana María Ramírez Ojeda (PhD)
Universidad de Córdoba, Spain
2021/03 Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy
(Thesis) Arguer
 Helena Rouco Taboada (PhD)
Universidade de Santiago de Compostela, Spain
2020/04/03 Drug encapsulation and controlled release via stimuli responsive nano and micro structured polymeric materials
(Thesis) Arguer
 Nieves Iglesias Blanco (PhD)
Universidad de Sevilla, Spain
2020/02 Diseño de sistemas nanoparticulares lipídicos para co-administración de teofilina y ciprofloxacino en el tratamiento de la fibrosis quística
(Thesis) Main arguer
 María Oliva Guerra Morillo (PhD)
Universidad de Sevilla Facultad de Farmacia, Spain
2019/09 Marine microalgae as sources of bioactive compounds with anti-inflammatory action
(Thesis) Main arguer
 Kovan Mohammed Ismael (Master)
Universidade do Algarve, Portugal
2019/01 Microencapsulated human albumin nanoparticles for drug delivery to the lungs
(Thesis) Arguer
 Ayasha Patel (PhD)
King's College London, United Kingdom
2018/06 Establishment of a three-dimensional in vitro model of air-blood barrier to assess the translocation of nanoparticles targeted to the lung
(Thesis) Main arguer
 Ana Margarida Costa (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/03 Extraction and Purification of Bioactive Compounds from Sargassum muticum
(Thesis) Main arguer
 Noelia Flórez Fernández (PhD)
Universidade de Vigo - Campus Ourense, Spain
2017/03 SLN spray drying in tuberculosis treatment
(Thesis) Arguer
 Diana Gaspar (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/12 Characterization of the effect of cartilage acidic protein (CRTAC) on human monocytes THP-1 cells
(Thesis) Main arguer
 André Coelho (Master)
Universidade do Algarve, Portugal
2016/06 Enhancement of non-viral transfection efficiency with nuclear localization signal peptides
(Thesis) Main arguer
 Joana Morais (Master)
Universidade do Algarve, Portugal
2016/04 Efeito da microgravidade simulada em fibroblastos de pele humana
(Thesis) Arguer
 Patricia Bellicanta (Master)
Pontifícia Universidade Católica do Rio Grande do Sul, Brazil
2015/12 Combination of nano and microcarriers for stem cell therapy of Huntington's disease: new regenerative medicine strategy
(Thesis) Main arguer
 Emilie André (PhD)
Université d'Angers, France

Universidade de Santiago de Compostela, Spain
2015/07 Towards a new approach to phenylketonuria treatment: stabilization of phenylalanine hydroxylase using nanobiomaterials
(Thesis) Arguer
 Paulo Roque Lino (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/12 Synthesis and evaluation of polymer nanoparticles for delivery in RPE cells
(Thesis) Main arguer
 Diogo Bitoque (Master)
Universidade do Algarve, Portugal
2013/03 Effects of active pharmaceutical ingredients in mussel mytilus galloprovincialis
Thesis Member
 Maria Margarida Ramos González Rey (PhD)
Universidade do Algarve, Portugal
2011/12 Synthesis of polymer nanoparticles sensitive to pH for DNA delivery in intracellular environment
(Thesis) Main arguer
 Eduardo Lopes (Master)
Universidade do Algarve, Portugal
2011/09 Self-assembled nanoparticles as new smart contrast agents for magnetic resonance imaging
(Thesis) Arguer
 Sonia N. Alqadi (PhD)
Universidade de Santiago de Compostela, Spain
2011/01 Self-assembled nanoparticles as new smart contrast agents for magnetic resonance imaging
(Thesis) Main arguer
 Teresa Simão (Master)
Universidade do Algarve, Portugal

Association member

Society Organization name Role
2018/01 - Current European Respiratory Society Membro associado
2018/01 - Current Sociedade Portuguesa de Pneumologia Membro associado
2005 - Current Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) Membro associado

Committee member

Activity description
Role 		Institution / Organization
2021/09 - 2023/07 Comissão de auto-avaliação do curso de Ciências Farmacêuticas da Universidade do Algarve, encarregue de preparar o processo de acreditação do curso de Ciências Farmacêuticas junto da A3ES. Considerado como tempo da atividade o tempo desde início da preparação do relatório de auto-avaliação até receção da decisão da A3ES.
Member
 Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2015/09 - 2019/05 Comissão de auto-avaliação do curso de Ciências Farmacêuticas da Universidade do Algarve, encarregue de preparar o processo de acreditação do curso de Ciências Farmacêuticas junto da A3ES. Considerado como tempo da atividade o tempo desde início da preparação do relatório de auto-avaliação até receção da decisão da A3ES.
Member
 Universidade do Algarve, Portugal

Conference scientific committee

Conference name Conference host
2023/12/06 - 2023/12/08 Drug Delivery to the Lungs - DDL2023 The Aerosol Society
2023/10/26 - 2023/10/28 X Congresso Iberoamericano de Ciências Farmacêuticas - COIFFA Faculdade de Farmácia - Universidade de Coimbra
2023/05/31 - 2023/06/02 EUFEPS Annual Meeeting 2023 Faculdade de Farmácia - Universidade de Lisboa
2022/12/09 - 2022/12/11 Drug Delivery to the Lungs - DDL2022
2021/12/08 - 2021/12/10 Drug Delivery to the Lungs - DDL 2021
2020/12/09 - 2020/12/11 DDL Christmas Lectures Aerosol Society
2020/02 - 2020/07 Controlled Release Society Annual Meeting and Exposition Controlled Release Society
2020/01 - 2020/01 Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) Santiago de Compostela
2019/12/11 - 2019/12/13 Drug Delivery to the Lungs 2019 Aerosol Society
2019/09 - 2019/09 22nd International Symposium on Microencapsulation Fundação Osvaldo Cruz
2018/12 - 2018/12 Drug Delivery to the Lungs 2018 Aerosol Society
2018/01 - 2018/01 Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) Universidade de Coimbra, Portugal
2017/09 - 2017/09 21st International Symposium on Microencapsulation Faro, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2016/11 - Current Comissão de Avaliação Externa da A3ES ( Agência de Avaliação e Acreditação do Ensino Superior) External evaluation comission from A3ES (the Portuguese Agency for Evaluation and Accreditation of Higher Education)
Evaluator

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019/04 Artigo de opinião na revista Visão Saúde, sob o título "Estamos perto de tratar a tuberculose com alfarroba, crustáceos e algas?" Visão Saúde
2017/12 Artigo de divulgação na Deco Proteste - Teste Saúde, com a reportagem "Investigação em Biomedicina" Deco Proteste - Teste Saúde

Interview (tv / radio show)

Program Topic
2022/06 - Current Participação no programa 90 segundos de ciência Imunização pulmonar para tratar as doenças respiratórias
2021/09 - Current Participação no podcast "Ciência com Impacto" A arte de encapsular medicamentos
2018/02/21 - Current Participação no programa da Rádio Universitária do Algarve "Projetoscópio" Aplicações da goma de alfarroba na área da saúde
2017/10/21 - Current Participação no programa "Os dias do futuro", rádio Antena 1 A goma de alfarroba como material promissor
2017/09/21 - Current Participação no programa "90 segundos de ciência", da rádio Antena 1 Alfarroba algarvia pode ajudar a tratar tuberculose
Distinctions

Award

2022 Prémio Investigador Universidade do Algarve
Universidade do Algarve, Portugal
2021 Mençao Honrosa - Prémio Ideias em Caixa
Ideias em Caixa - Caixa Geral de Depósitos /Universidade do Algarve, Portugal
2020 Prémio de Melhor Comunicação Oral SPP-Medinfar (Prize for Best Oral Presentation SPP-Medinfar)
Sociedade Portuguesa de Pneumologia, Portugal
2020 Prémio Robalo Cordeiro SPP / AstraZeneca / Novartis 2020 (ex-aequo)
Sociedade Portuguesa de Pneumologia, Portugal
2018 Prémio Tech2Market - Menção Honrosa
Universidade do Algarve, Portugal
2015 Poster on the Podium Award
2007 Most Cited Paper 2005 Award