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Lucília Saraiva (LS) holds a Degree in Pharmaceutical Sciences (1998) and a PhD in Pharmacology (2003), at the Faculty of Pharmacy of University of Porto (FFUP). In 2003, she started a post-doc work at the Department of Biological Sciences of University of Minho, and in 2005 she became Assistant Professor at the FFUP. Currently, she is Associate Professor with Aggregation at the FFUP. In 2013, she was involved in the conception and accreditation of the International Doctoral Program in Molecular and Cellular Biotechnology applied to Health Sciences (BiotechHealth), of which she is currently member of the scientific committee. Her research work has been focused in medical and health sciences with emphasis on pharmacology and pharmacy, particularly in cancer pharmacology, drug discovery, microbial and molecular biotechnology. In 2006, LS became principal investigator at the LAQV-REQUIMTE Research Centre, where she created her research group 3DUnit (Drug Discovery & Development Research Unit). The 3DUnit group has been focused on the development of genetically modified yeasts to be used as cellular models in a targeted screening of regulators of human proteins with key roles in carcinogenesis, followed by validation of the results in 2D and 3D (spheroids and organoids) models of human cells (including patient-derived cells) and xenograft mouse models. The developed humanized yeast models have been the basis of several service provision contracts with pharmaceutical companies. Through this targeted research approach, she has stood out for identifying new anticancer drug candidates for the personalized therapy of cancer, which have been the basis of one international and two national patents granted, as well as four international patent applications. Since the creation of 3DUnit, she has received 37 awards related to innovation and entrepreneurship. She is co-founder and CSO of the startup Beat Therapeutics (https://www.linkedin.com/company/beat-therapeutics/) (created in 2023). She has published 110 scientific articles in peer-reviewed international journals and 5 section(s) of books, and organized 42 scientific events. She has received funding for 26 research projects, 13 of which as PI (including two FCT projects) and two under international collaboration. She has been actively dedicated to the supervision of pre- and post-graduation students, having successfully concluded the supervision of 39 works of LSc/BSc students, 20 Master students , and 17 PhD students. She is Editor of three international journals with scientific refereeing in Pharmacology, Oncology and Biotechnology, and evaluator of international scientific projects. H-index (scopus): 26
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Identification

Personal identification

Full name
Lucília Helena Ataíde Saraiva

Author identifiers

Ciência ID
0A11-3A2E-8FE1
ORCID iD
0000-0002-9531-4939

Email addresses

  • lucilia.saraiva@ff.up.pt (Professional)

Telephones

Telephone
  • (+351) 220428584 (Professional)

Addresses

  • Universidade do Porto, Faculdade de Farmácia, Rua Jorge Viterbo Ferreira nº 228, 4050-313 , Porto, Porto, Portugal (Professional)

Websites

Education
Degree Classification
2024
Concluded
 Molecular and Cellular Biotechnology Applied to Health Sciences (Título de Agregado)
University of Porto, Faculty of Pharmacy, Portugal
2003
Concluded
 Pharmacology (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
"Implementation of a yeast phenotypic assay to search for selective modulators of individual mammalian PKC isoforms. " (THESIS/DISSERTATION)
 Aprovada
1998
Concluded
 Pharmaceutical Sciences (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2015 - Current Principal Investigator (Research) REQUIMTE LAQV Porto, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024 - Current Associate Professor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
2005/01/01 - 2024 Assistant Professor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
2003/01/01 - 2005/01/01 Assistant (University Teacher) University of Porto, Faculty of Pharmacy, Portugal
Projects

Grant

Designation Funders
2023 - 2025 Beat Therapeutics - Innov-ID, Portugal Ventures 3rd Edition award
Internal Ref
2023 - 2024 Exploiting monoterpene indole alkaloid derivatives for overcoming resistance in BRCA-deficient cancers. In silico characterization of binding modes - 2022.05718.PTDC
2022.05718.PTDC
 Fundação para a Ciência e a Tecnologia
Ongoing
2023 - 2024 "BtoBEAT-TNBC : Establishing lethal combinations with a first-in-class inhibitor of dna damage response against triple-negative breast cancer" Gilead GÉNESE
111-111-111
Principal investigator
2016/06 - 2019/05 Navigating through marine derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agentes
PTDC/MARBIO/4694/2014
Researcher
Fundação para a Ciência e a Tecnologia
2016/04 - 2019/03 Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2013/04 - 2016/03 Functional, molecular and pharmacological studies of p53 family proteins: from yeast to human cells
PTDC/SAU-FAR/110848/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
2013/07 - 2014/12 Regulation of Bax activation by the oncogene PKCepsilon: An approach to eliminate cancer cells
EXPL/BIM-ONC/0056/2012
Researcher
Fundação para a Ciência e a Tecnologia
2012 - 2014 Y1 receptor based therapy for local bone repair: Antagonist behavior and delivery in challenged bone microenvironment
TDC/BIM-MED/1047/2012
Researcher
Fundação para a Ciência e a Tecnologia
2011 - 2013 Novel canine norovirus: molecular, epidemiologic and pathogenic aspects
PTDC/CVT/113218/2009
Researcher
Fundação para a Ciência e a Tecnologia
2010 - 2012 Expression in yeast of a novel canine norovirus nucleocapsid protein for use in serological studies"
xxx
Researcher
University of Porto
Concluded
2010 - 2011 Functional and pharmacological studies of p53 family proteins: screening for selective small-molecule modulators
xxx
Principal investigator
University of Porto
Concluded
2009 - 2010 Searching for small-molecule modulators of caspase family members using yeast cell-based approaches
xxx
Principal investigator
University of Porto
Concluded
2009 - 2010 A yeast-based phenotypic screen for LRRK2 inhibitors
xxx
Researcher
University of Porto
Concluded
2009 - 2010 Synthesis of Flavonoids with Antitumoral Activity
xxx
Researcher
University of Porto
Concluded
2009 - 2010 Modeling and managing fungal colonization and inflammatory progression on cystic fibrosis patients
xxx
Researcher
University of Porto
2008 - 2010 Elucidation of ceramide-induced apoptosis: modulation of Protein Kinase C isoforms
PTDC/BIA-BCM/69448/2006
Researcher
Fundação para a Ciência e a Tecnologia
2008 - 2010 Colonization, inflammation and infection on Portuguese cystic fibrosis patients
xxx
Researcher
Fundação Calouste Gulbenkian
Concluded
2006 - 2007 Using yeast-based functional assays for the study of p53 signaling pathway, pharmacological screening and molecular characterization of small-molecules targeting p53 function
xxx
Principal investigator
University of Porto
Concluded
2005 - 2006 Study of the mechanisms of regulation of the tumour suppressor p53 protein by the isoform delta of protein kinase C (PKC): Using yeast as a cell model
xxx
Principal investigator
University of Porto
Concluded

Contract

Designation Funders
2021/12/01 - 2022/12/01 Astex Pharmaceuticals - p53-activating agent
XXX
Principal Investigator
Ongoing
2019/01/01 - 2019/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
UID/QUI/50006/2019
LA/P/0008/2020
10.54499/LA/P/0008/2020
Universidade do Porto Faculdade de Ciências, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Évora, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/06/01 - 2019/06/01 Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014
Provided by PTCRIS: 143327
POCI-01-0145-FEDER-016790
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Fundação Ensino e Cultura Fernando Pessoa, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 6 - 2011-2012
PEst-C/EQB/LA0006/2011
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Saraiva, Lucília. "Keeping p53 Active: The Challenge of Cancer Therapy". 2018.
  2. Saraiva, Lucília. "Flavones: Promising Basis for Drug Development of Caspase Activators". 2018.
  3. Saraiva, Lucília. "Natural products as lead Protein Kinase C modulators for cancer therapy". 2016.
  4. Matias, D.; Bessa, C.; Fátima Simões, M.; Reis, C.P.; Saraiva, L.; Rijo, P.. "Natural Products as Lead Protein Kinase C Modulators for Cancer Therapy". 2016.
    10.1016/B978-0-444-63749-9.00002-5
  5. "Nutrição e Crescimento Microbiano". In Microbiologia. Editora Lidel., 2007.
Conference abstract
  1. Loureiro, Joana B.; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Quaresma, Adelina; Barcherini, Valentina; Marabini, Laura; et al. "Abstract P030: Chemoprevention by the mutant p53 reactivator SLMP53-2 on ultraviolet radiation-induced skin cancer". 2021.
    Published • 10.1158/1535-7163.targ-21-p030
  2. Saraíva, Lucília; Cidade, Honorina; Moreira, Joana; Almeida, Joana; Loureiro, Joana; Ramos, Helena; Pinto, Madalena. "BP-C4: A new diarylpentanoid with potential activation of the p53 pathway". 2021.
    10.3390/ecmc2021-11462
  3. Isca, Vera; Bangay, Gabrielle; Ferreira, Ricardo; dos Santos, Daniel; Dinic, Jelena; Pesic, Milica; Saraiva, Lucilia; Afonso, Carlos; Rijo, Patricia. "Inhibition of P-glycoprotein activity to overcome multidrug resistance in cancer with new diterpene royleanones from <em>Plectranthus</em> spp.". 2021.
    10.3390/ecmc2021-11385
  4. Saraiva, Lucília; Loureiro, Joana; Ribeiro, Rita; Nazareth, Nair; Ferreira, Tiago; Lopes, Elizabeth; Gama, Adelina; et al. "Chemoprevention of ultraviolet B radiation-induced skin cancer with the mutant p53 reactivator SLMP53-2". 2021.
    10.3390/ecmc2021-11390
  5. Calheiros, Juliana; Saraiva, Lucília; Ramos, Helena; Carvalho, Carla; Barcherini, Valentina; M. M. Santos, Maria. "SLMP53-1 inhibits tumor cell growth through regulation of glucose metabolism and angiogenesis in a P53-dependent manner". 2020.
    10.3390/ecmc2020-07400
  6. Barcherini, Valentina; Almeida, Joana; Lopes, Elizabeth; Wang, Mi; Magalhães e Silva, Diogo; Mori, Mattia; Wang, Shaomeng; Saraiva, Lucília; Santos, Maria M. M.. "Optimizing the oxazoloisoindolinone family: Identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer". 2020.
    10.3390/ecmc2020-07503
  7. Moreira*, Joana; Saraíva, Lucília; Brandão*, Pedro; Almeida, Joana; Nazareth, Nair; E. Sampaio-Dias, Ivo; Vasconcelos, Vitor; et al. "Norhierridin B, a new hierridin B-based hydroquinone with improved antiproliferative activity". 2020.
    10.3390/ecmc2020-07491
  8. Ntungwe, Epole Ngolle; Vágvölgyie, Máté; Coelho, Jaime A. S.; Isca, Vera; Saraiva, Lucilia; Díaz-Lanza, Ana; Hunyadi, Attila; et al. "Chemical Composition and Biological Activity of Diterpenoids from <em>Plectranthus mutabilis</em>". 2020.
    10.3390/ecmc2020-07290
  9. Isca, VMS; Ntungwe, E; Almeida, JF; Ferreira, IM; Pereira, R; Siopa, F; Almeida, J; et al. "Molecular docking as a tool to design new royleanone derivatives for colon cancer therapy based on PKC-d modulation". 2019.
    10.1055/s-0039-3399909
  10. Santos, Maria; Barcherini, Valentina; Gomes, Sara; Espadinha, Margarida; Soares, Joana; Raimundo, Liliana; Gomes, Célia; et al. "Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity". 2019.
    10.3390/ecmc2019-06403
  11. Rijo, Patricia; Isca, Vera; Ntungwe, Epole; Tavares, Joana; Siopa, Filipa; Almeida, Joana; Saraiva, Lucilia; et al. "Design and molecular docking studies of new potential PKC-d activators based on royleanone scaffold". 2019.
    10.3390/ecmc2019-06297
  12. Raimundo, Liliana; Sousa, Emilia; Saraiva, Lucília; Gomes, Sara; Soares, Joana; Loureiro, Joana; Leão, Mariana; et al. "Targeting neuroblastoma with a new inhibitor of the TAp73 interaction with MDM2 and mutant p53". 2019.
    10.3390/ecmc2019-06305
  13. Raimundo, Liliana; Saraiva, Lucília; Espadinha, Margarida; Soares, Joana; Loureiro, Joana; Calheiros, Juliana; Nazareth, Nair; et al. "Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions". 2019.
    10.3390/ecmc2019-06306
  14. Ntungwe, Epole Ngolle; Isca, Vera; Tavares, Joana; Vágvölgyi, Máté; Amílcar, Roberto; Saraiva, Lucilia; Spengler, Gabriella; Hunyadi, Attila; Rijo, Patrícia. "Cytotoxic activity of coleon diterpenoids from Plectranthus mutabilis codd". 2019.
    10.3390/ecmc2019-06323
  15. "Strategies to Discover p53 Activators and a p73 Activator for Neuroblastoma. Proceedings 2019, 22, 56; doi:10.3390/proceedings2019022056". 2019.
  16. Barcherini, Valentina; Espadinha, Margarida; Soares, Joana; Gomes, Sara; Antunes, Alexandra; Saraiva, Lucília; Santos, Maria. "Enantiopure oxazoloisoindolinones: Promising small molecules for p53-based therapy with potential anticancer properties". 2018.
    10.3390/ecmc-4-05630
  17. Cidade, Honorina; Brandão, Pedro; Loureiro, Joana; Carvalho, Sylvie; Hamadou, Meriem; Cravo, Sara; Moreira, Joana; Pereira, Daniela; Pinto, Madalena. "New prenylchalcones targeting the MDM2-p53 protein-protein interaction: synthesis and evaluation of antitumor activity". 2018.
    10.3390/ecmc-4-05568
  18. Saraiva, Lucília. "Aminocarbazole alkaloid derivatives as potential modulators of p53 mutants.". Paper presented in Proceedings of 18th International Conference on MedicinalChemistry & Targeted Drug Delivery. Med Chem., 2017.
    10.4172/2161-0444-C1-037
  19. Saraiva, Lucília. "SLMP53-1: A New Reactivator of Mutant p53 with Potent in Vivo Antitumor Activity (MC17). Pharmaceuticals, 2016, 9 (15), 13-14". Paper presented in Pharmaceuticals, 2016.
  20. Saraiva, Lucília. "Xanthone as a valuable scaffold to identify new promising antitumor agents via inhibition of p53/p73:MDM2 interaction (P14). Pharmaceuticals, 2016, 9 (15), 35.". 2016.
  21. Saraiva, Lucília. "Enantiopure Tryptophanol-Derived Small Molecules: Synthesis and Cytotoxicity Evaluation (P59). Pharmaceuticals, 2016, 9 (15), 51-52". 2016.
  22. Cidade, Honorina; Moreira, Joana; Salazar, Sofia; Leão, Mariana; Pinto, Madalena; Saraiva, Lucília. "Promising caspase modulators with flavonoid scaffold". 2015.
    10.3390/ecmc-1-a013
  23. Saraiva, Lucília. "A selective activator of protein kinase C discovered using yeast. A selective activator of protein kinase C discovered using yeast". Paper presented in FEBS J 281 (Suppl. 1) 431-432, 2014.
  24. Saraiva, Lucília. "Chiral Oxazololactams: A Novel Chemotype of p53-MDM2 Interaction Inhibitors with Potential Antitumor Activity". Paper presented in EFMC – Internacional Symposium of Medicinal Chemistry, 2014.
  25. Bessa, C; Pereira, C; Maciel, C; Goncalves, J; Rijo, P; Simoes, M; Saraiva, L; et al. "A selective activator of protein kinase Cdelta identified using yeast". Paper presented in FEBS EMBO, 2013.
  26. Saraiva, Lucília. "Discovery of a new Small-molecule Inhibitor of p53-MDM2 Interaction. ChemMedChem, 2012, 197: ISCM 2012 (P264)". 2012.
  27. Saraiva, Lucília. "Discovery of new small-molecule caspase-7 activators. ChemMedChem, 2012, 142: ISCM 2012 (P142)". 2012.
  28. Saraiva, Lucília. "Discovery of a New Inhibitor of P53/MDM2 Interaction Using a Yeast Target-based Screening Strategy. European Journal of Cancer, 48, suppl. 5, S25¿S288". 2012.
  29. Saraiva, Lucília. "Distinct regulation of p53-mediated apoptosis by protein kinase C isoforms revealed by a yeast cell system. FEBS J 277 (S1), 172-173". Paper presented in 35th FEBS Congress - Molecules of life, 2010.
  30. Saraiva, Lucília. "A yeast model for LRRK2: biological studies and screening for small-molecule inhibitors. FEBS J 277 (S1), 253-254.". Paper presented in 35th FEBS Congress: Molecules of Life, 2010.
  31. Saraiva, Lucília. "Searching for small-molecule modulators of p53 activity and inhibitors of p53-MDM2 interaction using yeast expression systems. FEBS J 277 (S1), 173-174". Paper presented in 35th FEBS Congress: Molecules of Life, 2010.
  32. Saraiva, Lucília. "Vinyl sulfones as caspase inhibitors. Drugs Future 34: 176-176 suppl.". 2009.
  33. Saraiva, Lucília. "Inhibition of alpha, betaI, delta, heta and zeta protein kinase C isoforms by xanthones: Improvements towards selectivity. Drugs Future, 31 (Suppl. A), 154 (Abstract P232)". 2006.
  34. Saraiva, Lucília. "Isomeric kielcorins and dihydroxyxanthones: modulation of alpha, betaI, delta, eta and zeta PKC isoforms. Drugs Future, 27 (Suppl. A), 461 (Abstract P486)". 2002.
  35. Saraiva, Lucília. "Differential activation of classical and novel isoforms of PKC by mezerein and daphnetoxin. Fundamental & Clinical Pharmacology, 15 (Suppl. 1), 73 (Abstract 8P060)". 2001.
  36. Saraiva, Lucília. "Interactions between active and inactive phorbol esters on mammalian PKC isoforms revealed by an in vivo yeast phenotypic assay. Fundamental & Clinical Pharmacology, 15 (Suppl. 1), 73 (Abstract 9P229)". 2001.
  37. Hartley, Genevieve; Wheat, William; Coy, Jonathan; Dow, Steven. "Chelerythrine reverts the phenotypic effects of PKC-alpha activation on an in vivo yeast phenotypic assay. Br. J. Pharmacol., 127, 124P (Abstract P71)". Paper presented in Br. J. Pharmacol., 127, 124P (Abstract P71), 1999.
  38. Saraiva, Lucília. "Influence of the substituents at C-12 and C-13 on the activity of phorbol ester compounds on PKC-a, using an in vivo yeast phenotypic assay. Fundamental & Clinical Pharmacology, 13, 125S (Abstract PS25)". 1999.
  39. Saraiva, Lucília. "Structure-activity studies of phorbol ester compounds on PKC-alpha activation using an in vivo yeast phenotypic assay. Br. J. Pharmacol., 127, 123P (Abstract P72).". 1999.
Conference poster
  1. Mota, Inês; Almeida, Joana; Barros, Matilde; Resende, Diana; Almeida, Inês; Sousa, Emilia; Saraiva, Lucília. "LEM3: A Promising Anticancer Agent for Neuroblastoma Therapy by Targeting Tap73". Paper presented in 15º Encontro de Investigação Jovem da Universidade do Porto, 2022.
  2. Trovão, Filipa; Gomes, Ana Sara; Andrade Pinheiro, Benedita; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; Romão, Maria João; Saraiva, Lucília; Carvalho, Ana Luísa. "The loss of DNA binding function of a Human p53 mutant elucidated through X-ray crystallography". Paper presented in Ciência 2019, 2019.
  3. Trovão, Filipa; Gomes, Ana Sara; Andrade Pinheiro, Benedita; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; Romão, Maria João; Saraiva, Lucília; Carvalho, Ana Luísa. "Crystal structure of Human p53 R280K mutant (DNA binding domain) ¿ Explaining the loss of DNA binding". Paper presented in 7th National Meeting of Portuguese Users of Synchrotron Radiation (ENURS), 2018.
  4. Cidade, Honorina; Machado, C.; Pinto, P.; Almeida, J. D.; Brandão, Pedro; Loureiro, J.; Salvador, J.; et al. "New Chalcone Derivatives: Synthesis and Antitumor Activity Evaluation". Paper presented in 12th National Organic Chemistry Meeting/5th National Medicinal Chemistry Meeting, 2018.
  5. Gomes, Sara; Soares, Joana; Raimundo, Liliana; Pereira, Nuno; Monteiro, A.; Bessa, Claúdia; Gomes, Ana Sara; et al. "Reactivation of mutant p53R280K by SLMP53-1, a potential anticancer drug candidate". Paper presented in 7th International Mutant p53 Workshop, Melbourne, Australia, 2016.
  6. Bessa, Cláudia; Soares, Joana; Raimundo, Liliana; Fernandes, Bryan; Gomes, Célia; Reis, Flávio; Soares, Miguel Luz; et al. "Roy-Bz: a new small-molecule selective activator of protein kinase Cd with anticancer activity.". Paper presented in International Conference on Cancer Research and Targeted Therapy, 2016.
  7. Soares, Joana; Raimundo, Liliana; Pereira, Nuno; Gomes, Sara; Bessa, Claúdia; Gomes, Ana Sara; Gomes, C.; et al. "Identification of a new reactivator of mutant p53 with in vivo antitumor activity". Paper presented in nternational Conference on Cancer Research and Targeted Therapy, Baltimore, USA, 2016.
  8. Cidade, Honorina; Pereira, D.; Raquel T. Lima; Palmeira, Andreia; Seca, Hugo; Soares, J.; Gomes, Sara; et al. "New Inhibitors of p53-MDM2 Interaction With a Chalcone Scaffold". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, 2015.
  9. Palmeira, Andreia; Agostinho Lemos; Maria Emilia da Silva Pereira de Sousa; Saraiva, Lucília. "Xanthone as a valuable scaffold to identify new promising antitumor agents via inhibition of p53/p73:MDM2 interaction". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, Porto, 2015.
  10. Gomes, Ana Sara; Soares, Joana; Raimundo, Liliana; Monteiro, A.; Ramos, Helena; Santos, Maria; Saraiva, Lucília. "Targeting p53:MDM2/MDMX interaction by tryptophanol-derived oxazolopiperidone lactams". Paper presented in Integrative Structural Biology tools for the study of protein-ligand interactions (ISBIO 2015), 2015.
  11. Ramos, H.; Gomes, S.; Leão, M.; Soares, J.; Raimundo, L.; Queiroz, G.; Brandão, Pedro; et al. "LEM2: a new small molecule inhibitor of the p73-MDM2 interaction". Paper presented in 8th Meeting of Young Researchers at UP IJUP¿15, 2015.
  12. Palmeira, Andreia; Maria Emilia da Silva Pereira de Sousa; Saraiva, Lucília; Agostinho Lemos. "A hybridization approach to obtain new xanthone derivatives as potential inhibitors of p53:MDM2 interaction". Paper presented in III Encontro Nacional de Estudantes de Química, Aveiro, 2015.
  13. Lemos, Agostinho; Brandão, Pedro; Palmeira, Andreia; Pinto, Madalena; Saraiva, Lucília; Sousa, Emília. "Design and synthesis of new xanthone derivatives as potential disruptors of p53:MDM2 interaction". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  14. Raquel T. Lima; Pereira, Daniela; Seca, Hugo; soares, joana; Gomes, Sara; Raimundo, L.; Maciel, C.; et al. "Synthesis, screening and evaluation of the activity of new p53 activators in human tumour cell lines". Paper presented in I3S Scientific Retreat 2014, 2014.
  15. Brandão, Pedro; Carvalho, S.; Pereira, D.; Soares, J.; Cravo, Sara; Saraiva, Lucília; Pinto, Madalena; Cidade, Honorina. "Chalcones as promising small-molecule  inhibitors  of  p53-MDM2  interaction". Paper presented in International Symposium  on  Medicinal  Chemistry, 2014.
  16. Bessa, Cláudia; Harilal, Nilma; Pereira, Clara; Maciel, Cláudia; Gonçalves, Jorge; Rijo, Patrícia; Simões, Maria de Fátima; Saraiva, Lucília. "A selective activator of protein kinase Cd discovered using yeast.". Paper presented in FEBS EMBO, 2014.
  17. Bessa, Cláudia; Pereira, Clara; Maciel, Cláudia; Gonçalves, Jorge; Rijo, Patrícia; Simões, Maria de Fátima; Saraiva, Lucília. "A selective activator of protein kinase Cd identified using yeast.". Paper presented in 26th International Conference on yeast genetics and molecular biology, 2013.
  18. Bessa, Cláudia; Pereira, Clara; Machado, Joana; Gonçalves, Jorge; Rijo, Patrícia; Simões, Maria de Fátima; Saraiva, Lucília. "Using yeast to search for new selective activators of protein kinase C isoforms.". Paper presented in IJUP6th meeting of young researchers, 2013.
  19. Palmeira, Andreia; Maria Emilia da Silva Pereira de Sousa; Saraiva, Lucília; Neuza Marisa Brandão Machado. "Insights into the molecular mechanism of action of new inhibitors of p53:MDM2 interaction". Paper presented in 3º Encontro Nacional de Química Terapêutica (3ENQT), Universidade de Aveiro, 2012.
  20. Bessa, Cláudia; Leão, M.; Gonçalves, Jorge; Côrte-Real, Manuela; Costa, Vítor; Saraiva, Lucília. "Using yeast to study the regulation of mammalian protein kinase c isoforms by the ceramide pathway". Paper presented in XIX Jornadas de Biologia de Levedura ¿Professor Nicolau van Uden¿, 2012.
  21. Nascimento, São José; Pestana, Nazaré; Sousa, Isaura; Cabral, Miguel; Pinto, Eugénia; Peixe ,Luísa; Neto, Helena; et al. "Estudo da resistência bacteriana aos antibióticos e pesquisa da actividade antimicrobiana, imunomodeladora e anticancerígena de novos compostos químicos". Paper presented in Simpósio ¿Os farmacêuticos no sistema de saúde¿, 2005.
Journal article
  1. Carla Carvalho; Rita Silva; Teresa M. V. D. Pinho e Melo; Alberto Inga; Lucília Saraiva. "P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis". Cancers (2024): https://doi.org/10.3390/cancers16233978.
    10.3390/cancers16233978
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  74. Leão, M.; Gomes, S.; Bessa, C.; Soares, J.; Raimundo, L.; Monti, P.; Fronza, G.; Pereira, C.; Saraiva, L.. "Studying p53 family proteins in yeast: Induction of autophagic cell death and modulation by interactors and small molecules". Experimental Cell Research 330 1 (2015): 164-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84917677533&partnerID=MN8TOARS.
    10.1016/j.yexcr.2014.09.028
  75. Oliveira, M.; Pereira, C.; Bessa, C.; Araujo, R.; Saraiva, L.. "Hydrogen peroxide-induced secondary necrosis in conidia of Aspergillus fumigatus". Canadian Journal of Microbiology 62 2 (2015): 95-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956669792&partnerID=MN8TOARS.
    10.1139/cjm-2015-0561
  76. Soares J; Pereira NA; Monteiro A; Raimundo L; Queiroz G; Bisio A; Inga A; Santos MM; Saraiva L. "Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.". (2014): http://europepmc.org/abstract/med/25312347.
  77. Quintas, C.; Pinho, D.; Pereira, C.; Saraiva, L.; Gonçalves, J.; Queiroz, G.. "Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis". Journal of Neuroinflammation 11 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84910037446&partnerID=MN8TOARS.
    10.1186/s12974-014-0141-3
  78. Pereira, C.; Miguel Martins, L.; Saraiva, L.. "LRRK2, but not pathogenic mutants, protects against H2O 2 stress depending on mitochondrial function and endocytosis in a yeast model". Biochimica et Biophysica Acta - General Subjects 1840 6 (2014): 2025-2031. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897466706&partnerID=MN8TOARS.
    10.1016/j.bbagen.2014.02.015
  79. Pereira, C.; Lopes-Rodrigues, V.; Coutinho, I.; Neves, M.P.; Lima, R.T.; Pinto, M.; Cidade, H.; Vasconcelos, M.H.; Saraiva, L.. "Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays". European Journal of Pharmaceutical Sciences 54 1 (2014): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893050056&partnerID=MN8TOARS.
    10.1016/j.ejps.2013.12.017
  80. Leão, M.; Pereira, C.; Bisio, A.; Paiva, A.M.; Sousa, E.; Pinto, M.; Inga, A.; Saraiva, L.. "Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based approach". Biochemical Pharmacology 85 9 (2013): 1234-1245. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875712215&partnerID=MN8TOARS.
    10.1016/j.bcp.2013.01.032
  81. Leão, M.; Gomes, S.; Pedraza-Chaverri, J.; MacHado, N.; Sousa, E.; Pinto, M.; Inga, A.; Pereira, C.; Saraiva, L.. "a-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach". Journal of Natural Products 76 4 (2013): 774-778. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876902872&partnerID=MN8TOARS.
    10.1021/np400049j
  82. Bessa, C.; Pereira, C.; Leão, M.; Maciel, C.; Gomes, S.; Gonçalves, J.; Corte-Real, M.; Costa, V.; Saraiva, L.. "Using yeast to uncover the regulation of protein kinase Cd by ceramide". FEMS Yeast Research 13 7 (2013): 700-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886089759&partnerID=MN8TOARS.
    10.1111/1567-1364.12069
  83. Leão, M.; Gomes, S.; Soares, J.; Bessa, C.; MacIel, C.; Ciribilli, Y.; Pereira, C.; Inga, A.; Saraiva, L.. "Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity". FEBS Journal 280 24 (2013): 6498-6507. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889663663&partnerID=MN8TOARS.
    10.1111/febs.12552
  84. Eusebio, N.; Pinheiro, T.; Amorim, A.A.; Gamboa, F.; Saraiva, L.; Gusmão, L.; Amorim, A.; Araujo, R.. "SNaPaer: A Practical Single Nucleotide Polymorphism Multiplex Assay for Genotyping of Pseudomonas aeruginosa". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84878927365&partnerID=MN8TOARS.
    10.1371/journal.pone.0066083
  85. Pereira, C.; Saraiva, L.. "Interference of aging media on the assessment of yeast chronological life span by propidium iodide staining". Folia Microbiologica 58 1 (2013): 81-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871311692&partnerID=MN8TOARS.
    10.1007/s12223-012-0186-6
  86. Gomez-Casati, D.F.; Clemente, M.; Inga, A.; Saraiva, L.; Spampinato, C.P.. "Contribution of yeast and plant research for improving human health". Journal of Biomedicine and Biotechnology 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865013179&partnerID=MN8TOARS.
    10.1155/2012/738436
  87. Pereira, C.; Bessa, C.; Soares, J.; Leo, M.; Saraiva, L.. "Contribution of yeast models to neurodegeneration research". Journal of Biomedicine and Biotechnology 2012 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864922051&partnerID=MN8TOARS.
    10.1155/2012/941232
  88. Pereira, C.; Bessa, C.; Saraiva, L.. "Endocytosis inhibition during H 2O 2-induced apoptosis in yeast". FEMS Yeast Research 12 7 (2012): 755-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867653504&partnerID=MN8TOARS.
    10.1111/j.1567-1364.2012.00825.x
  89. Pereira, C.; Leão, M.; Soares, J.; Bessa, C.; Saraiva, L.. "New therapeutic strategies for cancer and neuro degeneration emerging from yeast cell-based systems". Current Pharmaceutical Design 18 27 (2012): 4223-4235. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866324519&partnerID=MN8TOARS.
    10.2174/138161212802430422
  90. Silva RD; Saraiva L; Coutinho I; Gonçalves J; Côrte-Real M. "Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms.". (2012): http://europepmc.org/abstract/med/22475513.
    10.2174/13816128112092492
  91. Pereira, C.; Coutinho, I.; Soares, J.; Bessa, C.; Leão, M.; Saraiva, L.. "New insights into cancer-related proteins provided by the yeast model". FEBS Journal 279 5 (2012): 697-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857642093&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2012.08477.x
  92. Silva, R.D.; Saraiva, L.; Coutinho, I.; Gonçalves, J.; Côrte-Real, M.. "Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms". Current Pharmaceutical Design 18 17 (2012): 2492-2500. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860467702&partnerID=MN8TOARS.
  93. Pereira, C.; Lopes, E.; Mesquita, J.R.; Nascimento, M.S.J.; Saraiva, L.. "Production and purification of theVP1 capsid protein of a novel canine norovirus using the Saccharomyces cerevisiae expression system". Journal of Microbiological Methods 91 3 (2012): 358-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868247565&partnerID=MN8TOARS.
    10.1016/j.mimet.2012.09.007
  94. Silva, R.D.; Manon, S.; Gonçalves, J.; Saraiva, L.; Côrte-Real, M.. "Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Ca". Experimental Cell Research 317 6 (2011): 781-790. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952191234&partnerID=MN8TOARS.
    10.1016/j.yexcr.2010.12.001
  95. Glória, P.M.C.; Coutinho, I.; Gonçalves, L.M.; Baptista, C.; Soares, J.; Newton, A.S.; Moreira, R.; Saraiva, L.; Santos, M.M.M.. "Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway". European Journal of Medicinal Chemistry 46 6 (2011): 2141-2146. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955606938&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.02.067
  96. Silva, R.D.; Manon, S.; Gonçalves, J.; Saraiva, L.; Côrte-Real, M.. "The importance of humanized yeast to better understand the role of Bcl-2 family in apoptosis: Finding of novel therapeutic opportunities". Current Pharmaceutical Design 17 3 (2011): 246-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958219652&partnerID=MN8TOARS.
    10.2174/138161211795049651
  97. Coutinho, I.; Pereira, C.; Pereira, G.; Gonçalves, J.; Côrte-Real, M.; Saraiva, L.. "Distinct regulation of p53-mediated apoptosis by protein kinase C and: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms". Experimental Cell Research 317 8 (2011): 1147-1158. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953079501&partnerID=MN8TOARS.
    10.1016/j.yexcr.2011.02.007
  98. Coutinho, I.; Pereira, G.; Leão, M.; Gonçalves, J.; Côrte-Real, M.; Saraiva, L.. "Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system". FEBS Letters 583 22 (2009): 3582-3588. http://www.scopus.com/inward/record.url?eid=2-s2.0-71749107322&partnerID=MN8TOARS.
    10.1016/j.febslet.2009.10.030
  99. Coutinho, I.; Pereira, G.; Simões, M.F.; Côrte-Real, M.; Gonçalves, J.; Saraiva, L.. "Selective activation of protein kinase C-d and -e by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U)". Biochemical Pharmacology 78 5 (2009): 449-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649774231&partnerID=MN8TOARS.
    10.1016/j.bcp.2009.04.026
  100. Pereira, C.; Silva, R.D.; Saraiva, L.; Johansson, B.; Sousa, M.J.; Côrte-Real, M.. "Mitochondria-dependent apoptosis in yeast". Biochimica et Biophysica Acta - Molecular Cell Research 1783 7 (2008): 1286-1302. http://www.scopus.com/inward/record.url?eid=2-s2.0-45049085090&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.03.010
  101. Saraiva, L.; Silva, R.D.; Pereira, G.; Gonçalves, J.; Côrte-Real, M.. "Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms". Journal of Cell Science 119 15 (2006): 3171-3181. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748290027&partnerID=MN8TOARS.
    10.1242/jcs.03033
  102. Saraiva, L.; Fresco, P.; Pinto, E.; Gonçalves, J.. "Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay". European Journal of Pharmacology 491 2-3 (2004): 101-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342626503&partnerID=MN8TOARS.
    10.1016/j.ejphar.2004.03.035
  103. Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Gonçalves, J.. "Inhibition of a, ßI, d, ¿ and ¿ protein kinase C isoforms by xanthonolignoids". Journal of Enzyme Inhibition and Medicinal Chemistry 18 4 (2003): 357-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042697461&partnerID=MN8TOARS.
    10.1080/147563601000118400
  104. Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Gonçalves, J.. "Inhibition of protein kinase C by synthetic xanthone derivatives". Bioorganic and Medicinal Chemistry 11 7 (2003): 1215-1225. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037375620&partnerID=MN8TOARS.
    10.1016/S0968-0896(02)00641-7
  105. Saraiva, L.; Fresco, P.; Pinto, E.; Gonçalves, J.. "Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-a, -ßI, d, -¿ and ¿". Journal of Enzyme Inhibition and Medicinal Chemistry 18 6 (2003): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344739767&partnerID=MN8TOARS.
    10.1080/14756360310001603158
  106. Saraiva, L.; Fresco, P.; Pinto, E.; Kijjoa, A.; Gonzalez, M.J.; Gonçalves, J.. "Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay". Planta Medica 68 11 (2002): 1039-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036862571&partnerID=MN8TOARS.
    10.1055/s-2002-35655
  107. Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Gonçalves, J.. "Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives". Bioorganic and Medicinal Chemistry 10 10 (2002): 3219-3227. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036336285&partnerID=MN8TOARS.
    10.1016/S0968-0896(02)00169-4
  108. Saraiva, L.; Fresco, P.; Pinto, E.; Portugal, H.; Gonçalves, J.. "Differential activation by daphnetoxin and mezerein of PKC-isotypes a, ßI, d and ¿". Planta Medica 67 9 (2001): 787-790. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035668810&partnerID=MN8TOARS.
    10.1055/s-2001-18843
  109. Lopes, I.; Carvalho, F.; Saraiva, L.; Ferreira, P.L.; Ribeiro, A.M.; Reis, M.; Ries, G.; et al. "Quality of life in asthma,Qualidade de vida na criança asmática". Nascer e Crescer 9 4 (2000): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034489342&partnerID=MN8TOARS.
Magazine article
  1. Soares, Joana; Leão, Mariana; Bessa, Cláudia; Gomes, Sara; Maciel, Cláudia; Raimundo, Liliana; Harilal, Nilma; Saraiva, Lucília. "Humanized yeast: in the front line of anticancer drug discovery.", Portuguese Society for Microbiology Magazine, 2012, https://spmicrobiologia.files.wordpress.com/2013/12/2013129-12b.pdf.

Intellectual property

Patent
  1. Saraiva, Lucília. 2022. "(3S)- AND (3R)-6,7-BIS(HYDROXYMETHYL)-1H,3H-PYRROLO[1,2-C]THIAZOLES AS P53 ACTIVATORS. US 17/254,048, EP 19730929.7. Publication Number WO 2019/243906 A1".
    Pending
  2. Saraiva, Lucília; et al.. 2020. "TRYPTOPHANOL-DERIVED OXAZOLOISOINDOLINONES: SMALL-MOLECULE P53 ACTIVATORS. European Patent EP3013833 A1; US patent nº 20160347765; Publication number: WO 2014/207688 A1 (Granted)".
    Granted/Issued
  3. Saraiva, Lucília. 2020. "NEW PHARMACEUTICAL COMPOUNDS, METHODS AND USES THEREOF - PCT/IB2021/058241, Publication Nº WO/2022/053998".
    Pending
  4. Bessa, Cláudia; Soares, Joana; Raimundo, Liliana; Gonçalves, Jorge; Simões, Maria de Fátima; Rijo, Patrícia; Saraiva, Lucília. 2017. "A small-molecule selective activator of protein kinase Cdelta.". Portugal.
    Expired
  5. Saraiva, Lucília; et al.. 2017. "ROY-BZ: A SMALL MOLECULE SELECTIVE ACTIVATOR OF PROTEIN KINASE CDELTA. PCT/IB2017/05063. Publication number WO2017134637 A1.".
    Pending
  6. Saraiva, Lucília; Santos, Maria M. M.; Pereira, Nuno A. L.; Pereira, Clara; Moreira, Sara; Leão, Mariana; Monteiro, Ângelo; Soares, Joana. 2016. "Tryptophanol-derived oxazoloisoindolinones: small-molecule p53 activators (WO2014207688A1, US9732091B2, EP3013833B1, PT3013833T)".
    Granted/Issued
  7. Saraiva, Lucília; Pinto, Madalena; et al.. 2015. "Inibidores da interação p53-MDM2. PCT/IB201350193. Publication number WO 2013/105037 A1".
    Expired
  8. Saraiva, Lucília; Gonçalves, J.; et al.. 2008. "Coleon U: A Selective activator of the novel protein kinase C (PKC) isoforms, PKC-delta and PKC-epsilon. Portuguese Patent PT103977 (Refª DP/01/2008/8482)".
    Granted/Issued

Other

Other output
  1. A simple linearization method unveils hidden enzymatic assay interferences. 2019. Pinto MF; Ripoll-Rozada J; Ramos H; Watson EE; Franck C; Payne RJ; Saraiva L; et al. http://europepmc.org/abstract/PPR/PPR68178.
    10.1101/528596
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/01 A p53 family-targeting agent for the improvement of neuroblastoma therapy. 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Faculdade de Medicina da Universidade de Coimbra
2023/02/01 Overcoming pancreatic cancer drug resistance with a new inhibitor of BRCA1-mediated homologous recombination. 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Faculdade de Medicina da Universidade de Coimbra.
2023/02/01 Targeting pancreatic cancer with a BRCAness inducer agent. 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Faculdade de Medicina da Universidade de Coimbra
2023/02/01 Chemoprevention of ultraviolet radiation-induced skin damage through mutant p53 reactivation. 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia
Faculdade de Medicina da Universidade de Coimbra (Portugal)
2023/02/01 3-(1,2,3-triazol-4-yl)-ß-carbolines and 3-(1h-tetrazol-5-yl)-ß-carbolines: synthesis and evaluation as anticancer agents. 53ª Reunião da Sociedade Portuguesa de Farmacologia, 41ª Reunião de Farmacologia Clínica e 22ª Reunião de Toxicologia,
Faculdade de Medicina da Universidade de Coimbra
2022/03/17 Targeting p53 for cancer treatment and prevention PhD Course in Clinical and experimental Oncology and Immunology
2022 Mutant p53 reactivator prevents ultraviolet B radiation-induced skin carcinogenesis 52.ª Reunião da Sociedade Portuguesa de Farmacologia, .40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia, 11-13 de fevereiro de 2022, Porto. (Portugal)
2021 Potential Anti-cancer Diterpenoids from Plectranthus mutabilis Codd. NPCRT-2021 | 27th January 2021-Virtual Conference, Organized by United Scientific Group.
2021 Abietane diterpenoids from Plectranthus mutabilis Codd. as potential chemotherapeutic agents. Online, 2nd Meeting of the Group of Portuguese Chemists Abroad of the SPQ, 10th June 2021.
2021 Abietane diterpenoids from Plectranthus mutabilis Codd. as P-gp modulators. Encontro Ciência 2021, 28th to 30th June 2020, Lisbon. Published online: https://www.encontrociencia.pt/2021/?accao=posters
2021 Synthesis of new water-soluble xanthones activators of TAp73 for neuroblastoma treatment. Simpósio da Faculdade de Farmácia da Universidade do Porto (SIFFUP) 2021, FFUP, Porto. (Portugal)
2021 BP-C4 analogues with improved growth inhibitory activity: Synthesis and biological activity evaluation. Simpósio da Faculdade de Farmácia da Universidade do Porto (SIFFUP) 2021, FFUP, Porto. (Portugal)
2021 SLMP53-2: A mutant p53 reactivator with promising activity in skin cancer prevention. Synthesis and biological activity evaluation. Simpósio da Faculdade de Farmácia da Universidade do Porto (SIFFUP) 2021, FFUP, Porto. (Portugal)
2021 Searching for improved lem2-derivatives for neuroblastoma therapy. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, 17 a 19 de fevereiro de 2021, FFUL, Lisboa. (Portugal)
2021 SLMP53-2: Promising anti-tumor activity in melanoma by targeting p53. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, 17 a 19 de fevereiro de 2021, FFUL, Lisboa. (Portugal)
2021 A xanthone with anticancer activity by potential inhibition of homologous recombination dna repair in breast and ovarian cancer. 51.ª Reunião da Sociedade Portuguesa de Farmacologia, 39.ª Reunião de Farmacologia Clínica e 20ª Reunião de Toxicologia, 17 a 19 de fevereiro de 2021, FFUL, Lisboa. (Portugal)
2020 REGULATION OF GLUCOSE METABOLISM, ANGIOGENESIS AND MIGRATION OF COLON CANCER BY THE P53 ACTIVATOR SLMP53-1 L Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia, 5-7 Fevereiro 2020, Coimbra
(Portugal)
2020 SLMP53-2: A MUTANT P 53 REACTIVATOR WITH PROMISING ACTIVITY IN SKIN CANCER PREVENTION L Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia, 5-7 Fevereiro 2020, Coimbra
(Portugal)
2020 NEW DIARYLPENTANOIDS: SYNTHESIS AND EVALUATION OF P53-MDM2/X INHIBITORY ACTIVITY L Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia, 5-7 Fevereiro 2020, Coimbra
(Portugal)
2020 NEW INHIBITOR OF THE BRCA1-BARD1 INTERACTION WITH ANTICANCER ACTIVITY IN BRCA1-DEFICIENT BREAST AND OVARIAN CANCERS L Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia, 5-7 Fevereiro 2020, Coimbra, Portugal.
(Portugal)
2020 Chemical composition and biological activity of diterpenoids from Plectranthus mutabilis. 6th International Electronic Conference on Medicinal Chemistry (ECMC2020).
2020 SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. International Electronic Conference on Medicinal Chemistry (ECMC2020).
2020 Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity. 6th International Electronic Conference on Medicinal Chemistry (ECMC2020).
2020 Optimizing the oxazoloisoindolinone family: identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer. 6th International Electronic Conference on Medicinal Chemistry (ECMC2020).
2020 Plectranthus mutabilis Codd as a source of Anti-MDR Diterpenoids. 3rd MC and 4th Working Group meeting, Stratagem CA17104, 27-28th February 2020 Belgrade Serbia.
2020 Uncovering new pharmacological opportunities in skin cancer prevention by targeting p53. 2º Encontro Nacional de Jovens Investigadores em Oncologia, 24 setembro 2020, Porto (Portugal)
2019 “Saccharomyces cerevisiae as a model organism” Curso de formação avançada “Model organisms in human disease: the right organism for a specific question”
Faculdade de Farmácia, Universidade do Porto (Portugal)
2019 “Targeting tumor suppressor p53 for cancer therapy: challenges and opportunities” Seminars of PhD program in Biomolecular Sciences, Department CIBIO, University of Trento
University of Trento, Itália (Italy)
2019 "Strategies to discover p53 activators and a p73 activator for neuroblastoma" 2nd Molecules Medicinal Chemistry Symposium - Facing Novel Challenges in Drug Discovery, Barcelona, Espanha, 15-17 de maio de 2019.
(Spain)
2019 Diarylpentanoids as potential inhibitors of the p53-MDM2/X interactions Simpo´sio de Investigac¸a~o da Faculdade de Farma´cia da Universidade do Porto (SIFFUP) 2019
FFUP
2019 Targeting Neuroblastoma with a new TAP73 activator. XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia
(Portugal)
2019 Manio: A new potential anticancer drug candidate by targeting p53. XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia.
(Portugal)
2019 Improving colon cancer therapy using a novel p53-activating agent. XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica, XVIII Reunião de Toxicologia.
(Portugal)
2019 SLMP53-1 as new anticancer drug candidate: exploring its impact on p53. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia.
(Portugal)
2019 Cytotoxic Activity of Coleon Diterpenoids from Plectranthus mutabilis Codd. 5th International Electronic Conference on Medicinal Chemistry, 1st to 30th November 2019.
2019 Plectranthus species: as a source of anti-MDR diterpenoids. Working Group, WG1 meeting, Action: COST, CA17104, 20th September 2019 Vienna Austria.
2018 Novel small molecule PKCd-selective activator in colon cancer therapy. COST Action CM1407, 5th MC/WG Meeting Salini Resort
(Greece)
2018 Synthesis and stability studies of tryptophanol-derived compounds with anti-cancer activity. COST Action CM1407. “Challenging organic syntheses inspired by nature-from natural products chemistry to drug discovery”
(Spain)
2018 6,7-dehydroroyleanone: insights on cell death targets. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia.
(Portugal)
2018 LEM2 activates p73 by disrupting its interaction with MDM2 and mutant p53. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia.
(Portugal)
2018 SLMP53-2: a reactivator of mutant p53Y220C with in vivo antitumor activity. XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXVI Reunião de Farmacologia Clínica, XVII Reunião de Toxicologia.
(Portugal)
2017 "Targeting the P53 pathway" ESMO Congress, 08 Sep - 12 Sep 2017
(Spain)
2017 “Targeting tumor suppressor p53 for cancer therapy: challenges and opportunities” CNC.IBILI Seminars
University of Coimbra (Portugal)
2017 Tryptophanol-derived oxazoloisoindolinones: promising small molecules for anticancer therapy 3rd Working Group Meeting, EU COST CMST Action CM1407
(Poland)
2017 Uncovering the binding of the anticancer small molecule SLMP53-1 to mutant p53R280K. SPF 2017 – XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXV Reunião de Farmacologia Clínica, XVI Reunião de Toxicologia
(Portugal)
2017 Targeting colon cancer with the selective pkcdelta activator Roy-bz. SPF 2017 – XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXV Reunião de Farmacologia Clínica, XVI Reunião de Toxicologia
(Portugal)
2017 SLMP53-2 binds to mutant p53Y220C restoring wild-type-like antitumor activity. SPF 2017 – XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXV Reunião de Farmacologia Clínica, XVI Reunião de Toxicologia
(Portugal)
2016 “Humanized yeast models in targeted drug discovery: contributions to cancer therapy” Course Medicinal Chemistry, organizado pelo Programa Doutoral PhD Medicines and Pharmaceutical Innovation (i3DU)
Faculdade de Farmácia, Universidade de Lisboa (Portugal)
2016 Enhanced cytotoxicity against human tumour cells using prenylated chalcones through disruption of the p53-MDM2 interaction XXII ELGQ - XXII Encontro Luso-Galego de Química. XXII ELGQ
(Portugal)
2016 Identification of a new reactivator of mutant p53 with in vivo antitumor activity Encontro Anual Departamento Ciências Biológicas da Faculdade de Farmácia Universidade do Porto
(Portugal)
2016 Roy-Bz: A small-molecule selective activator of protein kinase C delta with anticancer properties XIX National Congress of Biochemistry
(Portugal)
2016 Flavonoid derivatives with caspase modulatory activity . IJUP 2016 - 9ª Edição do Encontro Investigação Jovem da Universidade do Porto
(Portugal)
2016 Prenylated chalcones with enhanced cytotoxicity against tumor cells through disruption of the p53-MDM2 interaction IJUP 2016 - 9ª Edição do Encontro Investigação Jovem da Universidade do Porto
(Portugal)
2016 Targeting p53 -MDM2 interaction with LEM2-aminated derivatives for cancer therapy IJUP 2016 - 9ª Edição do Encontro Investigação Jovem da Universidade do Porto
(Portugal)
2016 The diterpenoid roy-bz: first small molecule selective activator of protein kinase Cdelta XLVI Reunião da Sociedade Portuguesa de Farmacologia, XXXIV Reunião de Farmacologia Clínica, XV Reunião de Toxicologia
(Portugal)
2016 DIMP53-1: a novel dual inhibitor of p53-MDMs interactions with potent in vivo antitumor activity XLVI Reunião da Sociedade Portuguesa de Farmacologia, XXXIV Reunião de Farmacologia Clínica, XV Reunião de Toxicologia
(Portugal)
2016 A new dual p53-MDMs interactions inhibitor with promising application in combined therapy XLVI Reunião da Sociedade Portuguesa de Farmacologia, XXXIV Reunião de Farmacologia Clínica, XV Reunião de Toxicologia
(Portugal)
2016 Tryptophanol-derived oxazoloisoindolinones reactivate mutant forms of p53 XLVI Reunião da Sociedade Portuguesa de Farmacologia, XXXIV Reunião de Farmacologia Clínica, XV Reunião de Toxicologia
(Portugal)
2015 “Investigação em Farmacologia Oncológica” Investigação em Farmacologia: Presente e Futuro
Liga Portuguesa Contra o Cancro (LPCC), Núcleo Regional do Norte (Portugal)
2015 Novel small molecules with in vitro antitumor activity via inhibition of p53-MDM2 interaction 6th European Conference EuChem for Life Sciences
(Portugal)
2015 New potential selective activators of caspase-7 identified using the yeast screening assay II Simposio de Jovenes Investigadores de La Sociedad Espanola de Química Terapêutica
(Spain)
2015 SLMP53-1: a new reactivator of mutant p53 with potent in vivo antitumor activity Congresso de Química Orgânica e Química Terapêutica, 1-3 Dezembro 2015, Porto
(Portugal)
2015 Roy-Bz: the first small molecule selective activator of protein Kinase Cd. Congresso de Química Orgânica e Química Terapêutica, 1-3 Dezembro 2015, Porto
(Portugal)
2015 Xantonas como fonte de inspiração para a obtenção de novos inibidores da interação p53/p73:MDM2 1º Encontro Científico do Núcleo de Estudantes de Química da Associação Académica de Coimbra
(Portugal)
2015 A hybridization approach to obtain new xanthone derivatives as potential inhibitors of p53:MDM2 interaction III Encontro Nacional de Estudantes de Química, Aveiro
(Portugal)
2015 LEM2: a new small molecule inhibitor of the p73-MDM2 interaction. IJUP 2015- 8th meeting of young researchers of University of Porto
(Portugal)
2015 Discovery of a tryptophanol-derived oxazolopiperidone lactam OXAZ-1 with promising antitumor activity via dual inhibition of the p53-MDM2/MDMX interaction IJUP 2015- 8th meeting of young researchers of University of Porto
(Portugal)
2015 Xanthone as a promising scaffold to develop new potential inhibitors of p53:MDM2 interaction IJUP'15 - 8º Encontro de Investigação Jovem da Universidade do Porto, Porto
(Portugal)
2015 OXAZ-1: A novel small molecule with promising antitumor activity by dual inhibition of the p53-MDM2/MDMX interaction XLV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIII Reunião de farmacologia Clínica, XIV Reunião de Toxicologia
(Portugal)
2015 SLMP53-1: a new reactivator of mutant p53 with potent antitumor activity. XLV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIII Reunião de farmacologia Clínica, XIV Reunião de Toxicologia
(Portugal)
2015 Identification of a selective small molecule activator of PKCdelta with potential antitumor properties. XLV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIII Reunião de farmacologia Clínica, XIV Reunião de Toxicologia
(Portugal)
2015 Novel yeast-based approaches to search for inhibitors of the interaction of p53 family proteins with MDM2/MDMX. XLV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIII Reunião de farmacologia Clínica, XIV Reunião de Toxicologia
(Portugal)
2015 A new inhibitor of the p53-MDM2 interaction derived from naturally occurring chalcones XLV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXIII Reunião de farmacologia Clínica, XIV Reunião de Toxicologia
(Portugal)
2014 N-tosylindole OXAZ-1: a novel dual inhibitor of the p53-MDM2/MDMX interaction with promising antitumor activity XX Encontro Luso-Galego de Química
(Portugal)
2014 A selective activator of protein kinase Cdelta discovered using a yeast-based assay. XX Jornadas de Biologia de Leveduras Professor Nicolau van Uden
Campus da Alameda do Instituto Superior Técnico (IST), Universidade de Lisboa (Portugal)
2014 A new small-molecule activator of wild-type and mutant p53 with potential antitumor properties XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião de farmacologia Clínica, XIII Reunião de Toxicologia
(Portugal)
2014 LEM2: A potential inhibitor of the p73-MDM2 interaction XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião de farmacologia Clínica, XIII Reunião de Toxicologia
(Portugal)
2014 A novel selective small molecule activator of protein kinase Cdelta XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião de farmacologia Clínica, XIII Reunião de Toxicologia, Coimbra
(Portugal)
2014 Microglia P2y6 Receptors Mediate Nitric Oxide Release And Astrocyte Apoptosis In Primary Glial Cultures Of Newborn Wistar Rats XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXII Reunião de farmacologia Clínica, XIII Reunião de Toxicologia, Coimbra
(Portugal)
2014 A new selective activator of PKCdelta discovered using a yeast-based assay. IJUP 2014 - 7th Meeting of Young Researchers of University of Porto, Porto
(Portugal)
2014 Discovery of a new small molecule inhibitor of the p53-MDM2 interaction. IJUP 2014 - 7th Meeting of Young Researchers of University of Porto, Porto
(Portugal)
2013 Small-molecule activators of caspase-7 with potential antitumor activity identified using a yeast assay XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de farmacologia Clínica, XII Reunião de Toxicologia, Porto
(Portugal)
2013 Identification of potential activators of p53 activity using yeast-based screening assays XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de farmacologia Clínica, XII Reunião de Toxicologia, Porto
(Portugal)
2013 Discovery of a new small-molecule inhibitor of p53-MDM2 interaction using a yeast-based screening assay. XLIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXXI Reunião de farmacologia Clínica, XII Reunião de Toxicologia, Porto
(Portugal)
2013 Virtual screening of a focused library of cell growth inhibitors to identify potential inhibitors of p53:MDM2 interaction IJUP 2013 - 6th Meeting of Young Researchers of University of Porto, Porto
(Portugal)
2012 “Yeast as a tool for anticancer drug research” Course Mammalian and yeast as complementary cell models in programmed cell death (3ª edição)
Departamento de Biologia da Universidade do Minho (Portugal)
2012 Insights into the molecular mechanism of action of a new inhibitor of p53:MDM2 interaction 6TH Braziliam Symposium on Medicinal Chemistry
(Brazil)
2012 A new small-molecule inhibitor of p53-MDM2 interaction discovered using a yeast cell-based screening assay 3º Encontro Nacional de Química Terapêutica, 28-30 November, Aveiro
(Portugal)
2012 A new inhibitor of p53-MDM2 interaction discovered using a yeast target-based screening approach As XIX Jornadas de Biologia de Leveduras “Professor Nicolau van Uden”
(Portugal)
2012 Using yeast to study the regulation of mammalian protein kinase C isoforms by the ceramide pathway XIX Jornadas de Biologia de Leveduras “Professor Nicolau van Uden”
(Portugal)
2012 Discovery of potent small-molecule caspase-7 activators using yeast target-based screening assays XIX Jornadas de Biologia de Leveduras “Professor Nicolau van Uden”
(Portugal)
2011 “Utilização de sistemas microbiológicos no estudo do cancro: pesquisa de novos fármacos anticancerígenos” Seminários em Microbiologia Clínica, Edição 2011
Faculdade de Ciências da Saúde da Universidade Fernando Pessoa (Portugal)
2011 “Yeast as a Drug Screening Tool” Course Yeast: A Valuable Research Tool
Faculdade de Farmácia da Universidade do Porto (Portugal)
2011 “Yeast as a tool for anticancer drug research” Course Mammalian and yeast as complementary cell models in programmed cell death.
Organizado pelo Departamento de Biologia da Universidade do Minho (Portugal)
2011 Distinct regulation of p53-mediated apoptosis by protein kinase Calpha, delta, epsilon and zeta: evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms In: 14th Portugaliae Genetica "Model organisms: humans et al."
IPATIMUP (Portugal)
2011 A utilização da levedura no estudo do cancro: pesquisa de novos fármacos anticancerígenos. III Conferência sobre Microbiologia e Biologia do Cancro
Faculdade de Farmácia da Universidade do Porto (Portugal)
2011 Leveduras “humanizadas”: na vanguarda da descoberta de novos agentes terapêuticos Química Terapêutica e Novas Tecnologias: a Inovação ao Serviço da Saúde
Sociedade Portuguesa de Química (Portugal)
2011 Distinct regulation of p53-mediated apoptosis by protein kinase Calpha, delta, epsilon and zeta, revealed by a yeast cell system XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia
(Portugal)
2011 Searching for small molecule inhibitors of p53-MDM2/MDMX interaction using yeast cell-based assays XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIX Reunião de Farmacologia Clínica e X Reunião de Toxicologia
(Portugal)
2010 “Utilização de leveduras em estudos funcionais e farmacológicos de proteínas e processos biológicos associados a patologias humanas” Seminários em Microbiologia Clínica
Organizado pela Faculdade de Ciências da Saúde da Universidade Fernando Pessoa (Portugal)
2010 Modulation of Bax by Mammalian Protein Kinase Calpha in Yeast XVIII Jornadas de Biologia de Leveduras Nicolau Van Uden, Lisboa
(Portugal)
2009 “Utilização de leveduras em estudos funcionais e farmacológicos de proteínas e processos biológicos associados a patologias humanas” Seminários em Microbiologia Clínica
Organizado pela Faculdade de Ciências da Saúde da Universidade Fernando Pessoa (Portugal)
2009 Modulation of Bax by Mammalian Protein Kinase Calpha in Yeast 7th International Meeting on Yeast Apoptosis
(Austria)
2009 Protein kinase C-alpha modulates Bax-induced cell death in yeast XVII Jornadas de Biologia de Leveduras "Professor Nicolau Van
University of Minho, Minho (Portugal)
2009 Searching for small-molecule modulators of p53 activity and inhibitors of MDM2-p53 interaction, using yeast expression systems XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia, Porto
(Portugal)
2009 Development of a yeast-based system to search for LRRK2 mutant inhibitors XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia, Porto
(Portugal)
2009 Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system
XL Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia, Porto (Portugal)
2009 Protein Kinase Calpha modulates Bax-induced cell death in yeast XVII Jornadas de Biologia de Leveduras "Professor Nicolau Van, University of Minho
(Portugal)
2009 Identification of a selective activator of protein kinase c-delta and -epsilon, coleon u, using a yeast expression system XVII Jornadas de Biologia de Leveduras "Professor Nicolau Van, University of Minho, Minho
(Portugal)
2009 Using Yeast-Cell Based Assays for the Screening of Small-Molecule Modulators of p53 Activity and Inhibitors of MDM2-p53 Interaction XVII Jornadas de Biologia de Leveduras "Professor Nicolau Van, University of Minho, Minho
(Portugal)
2009 Using a yeast expression system to study the regulation of p53 activity by protein kinase C isoforms IJUP09 2nd Meeting of Young Researchers of U. Porto, Porto
(Portugal)
2008 “Yeast as a tool for anticancer drug research” Course Mammalian and yeast as complementary cell models in programmed cell death
Departamento de Biologia da Universidade do Minho (Portugal)
2008 Yeast as a new approach to study the regulation of p53 activity by distinct protein kinase C isoforms 12th International Congress on Yeasts (ICY 2008)
(Ukraine)
2008 Coleon U stimulates an apoptotic cell death dependent on selective activation of novel protein kinase Cdelta and epsilon XXXIX Reunião Anual da Sociedade Portuguesa de Farmacologia, XXVI Reunião de Farmacologia Clínica e VIII Reunião de Toxicologia, Lisbon
(Portugal)
2008 Contributions of yeast biology to the understanding of cell death regulation. XVI Jornadas de Biologia de Leveduras "Professor Nicolau Van Uden, Vimeiro
(Portugal)
2008 Yeast as a New Approach to Study the Regulation of p53-dependent Apoptosis by Protein Kinase C-delta IJUP08 First Meeting of Young Researchers of U. Porto
(Portugal)
2007 A new Approach to Study the Regulation of p53-dependent Apoptosis by Protein Kinase C-delta XV Jornadas de Biologia de Leveduras "Professor Nicolau Van Uden, Porto
(Portugal)
2006 Integrating mammalian protein expression and yeast apoptosis towards understanding cell death regulation 5th International Meeting on Yeast Apoptosis
(Czech Republic)
2005 Effects of mammalian PKC-alpha, -delta, -epsilon and -zeta in Saccharomyces cerevisiae acetic acid-induced apoptosis: an approach for the study of apoptosis regulation by individual PKC isoforms 4rd International Meeting on Yeast Apoptosis
(United States)
2005 Cell death with apoptotic phenotype in yeast XX Congreso Nacional Microbiologia
(Spain)
2005 Effects of mammalian PKC-alpha, -delta, -epsilon and -zeta in Saccharomyces cerevisiae induced apoptosis: an approach to study apoptosis regulation by individual PKC isoforms XXXV Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIII Reunião de Farmacologia Clínica, Lisboa
(Portugal)
2004 Regulation of Saccharomyces cerevisiae programmed cell death by mammalian protein kinase C (PKC) isoforms 3rd International Meeting on Yeast Apoptosis
(Austria)
2002 Inhibition of protein kinase C by synthetic kielcorin derivatives XXXIII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica, Lisboa
(Portugal)
2002 Characterization of the selectivity of PKC inhibitors using an in vivo yeast phenotypic assay XXXIII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXI Reunião de Farmacologia Clínica, Lisboa
(Portugal)
2001 Modulatory activity of protein kinase C by xanthone derivatives 18th International Congress of Heterocyclic Chemistry
(Japan)
2001 Modulatory activity of PKC-alpha, -betaI, -delta, -eta and -zeta by xanthonic derivatives. XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica, Coimbra
(Portugal)
2000 Síntese e avaliação da actividade moduladora da proteína cínase C por derivados xantónicos 23ª Reunião Anual da Sociedade Brasileira de Química
(Brazil)
2000 Differential activation of classical, novel and atypical isoforms of PKC by phorbol esters XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica, Porto
(Portugal)
2000 Daphnetoxin extracted from Daphne gnidium is able to activate alpha, betaI and delta but not zeta PKC isoforms XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica, Porto
(Portugal)
2000 Modulation of alpha, beta1, delta and zeta isoforms by xanthonic derivatives XXXI Reunião da Sociedade Portuguesa de Farmacologia e XIX Reunião de Farmacologia Clínica, Porto
(Portugal)
1999 Modulation of a and bI isoforms of protein kinase C (PKC) by xanthonic derivatives, detected by an in vivo phenotypic yeast assay XXX Reunião da Sociedade Portuguesa de Farmacologia e XVIII Reunião de Farmacologia Clínica, Lisboa
(Portugal)
1999 Selective activation of the alpha and betaI isoforms of protein kinase C (PKC) by phorbol esters, detected by an in vivo phenotypic yeast assay XXX Reunião da Sociedade Portuguesa de Farmacologia e XVIII Reunião de Farmacologia Clínica, Lisboa
(Portugal)
1998 Influence of substituents at C-12 and C-13 on the potency and selectivity of phorbol ester compounds as activators of PKC-alpha using a yeast phenotypic assay XXIX Reunião da Sociedade Portuguesa de Farmacologia e XVII Reunião de Farmacologia Clínica, Lisboa
(Portugal)
1998 Structure-activity studies of phorbol ester compounds on PKC-alpha using an yeast phenotypic assay 1st IPSF Scientific Symposium, Coimbra
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/01/01 - Current Targeting pancreatic cancer with a first-in-class inhibitor of DNA damage repair: seeking for optimized derivatives. FCT: Ref. 2024.03484.BDANA,
Supervisor
2024 - Current Novel spiroabietanes for the treatment of lung and colorectal cancer. FCT: Ref. 2024.00332.BDANA
Co-supervisor
2023 - Current Expanding the therapeutic potential of targeting DNA damage response with lethal combinations to treat ovarian and prostate cancer, FCT, Ref. UI/BD/154513/2023
Supervisor
2023 - Current Searching for new neuroprotective agents by targeting LRRK2
Supervisor
2021 - Current Semisolid formulations containing fisetin-loaded nanocapsules funcionalized with Melanocyte Simulating Hormone to improve melanoma treatment FCT - 2020.04785.BD
Co-supervisor of Letícia Sias da Fonseca
PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2021 - Current Targeting colorectal cancer with optimized p53-activating agents: moving towards clinical translation - FCT - 2021.06305.BD
Supervisor of Carla Sofia Costa Carvalho
 PhD in Pharmaceutical Sciences (PhD)
Fundação para a Ciência e a Tecnologia, Portugal
2021 - Current SEEKING OPTIMIZED TAP73-TARGETING AGENTS FOR NEUROBLASTOMA TREATMENT
Supervisor of Inês Maria da Mota
2020/10/01 - Current Improving neuroblastoma therapy with p53 family-targeting agents. FCT - 2020.05026.BD
Supervisor of Joana Almeida
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2019 - Current Novel ß-Carbolines with Anti-cancer Activity - PD/BD/143160/2019
Co-supervisor of João Luís Pinto Ribeiro
 PhD in Chemistry (PhD)
Universidade de Coimbra, Portugal
2020/10/01 - 2025 Targeting BRCA1-mediated DNA damage repair for personalized cancer therapy of hard-to-treat cancers. FCT - 2020.04613.BD
Supervisor of Juliana Calheiros
 PhD in Pharmaceutical Sciences. (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2023/10/20 New class of protein kinase C modulators: from ethnopharmacological to nanoparticles, FCT, Ref. SFRH/BD/137671/2018
Co-supervisor of Vera Sousa Isca
2022 - 2023 Seeking for inhibitors of leucine-rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease
Supervisor of Pedro Barros Gomes
Master in Pharmaceutical Chemistry (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022 - 2023 Targeting BRCA1-mediated DNA repair in pancreatic ductal adenocarcinoma therapy
Supervisor of João Pedro da Costa e Ventura Morais
 Mestrado em Oncologia do ICBAS (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2023 “Seeking for New Preventive Agents Against Skin Cancer Formation by Targeting the Mutant p53 Pathway”
Supervisor
 Licenciatura em Bioquímica da FCUP/ICBAS - Unidade Curricular de Estágio (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2022 Seeking optimized TAP73-targeting agents for neuroblastoma treatment
Supervisor of Inês Maria Ferreira da Mota
 Master in Oncology (Master)
Universidade do Porto, Portugal
2021 - 2022 Targeting BRCA2-Mediated DNA Repair in Pancreatic Ductal Adernocarcinoma Therapy
Supervisor of Rita Alexandra Machado Silva
Internship in Biochemistry (Degree)
Universidade do Porto, Portugal
2021 - 2022 TARGETING BRCA2-MEDIATED DNA REPAIR IN PANCREATIC DUCTAL ADENOCARCINOMA THERAPY
Supervisor of Adriana Gomes
 Master Degree in Biochemistry (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2022 New opportunities in skin cancer prevention and treatment by targeting p53. FCT - SFRH/BD/128673/2017
Supervisor of Joana Cristina Barbosa Loureiro
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2020 - 2021 Improving skin cancer prevention and treatment by targeting p53
Supervisor of Rita Ribeiro
 Master in Biochemistry (Master)
2020 - 2021 Improving neuroblastoma therapy with TAp73-targeting agents
Supervisor of Mariana Silva
 Mestrado em Química Farmacêutica da FFUP (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2020 - 2021 Targeting brca1 tumour suppressor protein: searching for new effective anticancer therapeutic options
Supervisor of Ana Mafalda Silva
Biology Internship (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020 - 2021 Targeting BRCA1 and BRCA2 Tumour Suppressor Proteins in Breast and Ovarian Cancers
Supervisor of Ana Filipa Moreira Bessa
Biochemistry Internship (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2020/09/24 Targeting BRCA1 and p53 family of tumor supressors in cancer. FCT - SFRH/BD/117949/2016
Supervisor of Liliana Sofia Gomes Raimundo
 PhD in Biotechnology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2020/09/09 Seeking for new p53-activating agents: effective therapies for colorectal cancer. FCT - SFRH/BD/119144/2016
Supervisor of Helena Isabel Nogueira Ramos Rocha
 PhD in Biotechnology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2020 Seeking new therapeutic opportunities for skin cancer prevention and treatment using p53-targeting agents
Supervisor of José Esteves
Master Degree in Oncology, ICBAS, University of Porto (Master)
2019 - 2020 Pesquisa de ativadores de formas mutadas da p53 com atividade antitumoral
Supervisor of Cláudia Martins Chaves
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2019 - 2020 Targeting BRCA1 tumour suppressor protein: searching for new effective anticancer therapeutic options
Supervisor of Beatriz Gomes Domingues
 Estágio da Licenciatura em Biologia da Faculdade de Ciências da Universidade do Porto (Degree)
2019 - 2020 Improving Colon Cancer Therapy with a New Mutant P53-Targeting Agent
Supervisor of José Pedro Araújo e Silva
 Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2019 - 2020 Sintese de analogos de calconas com potencial atividade na p53
Co-supervisor of Danilo Emanuel Moreira Correia
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2018 - 2019 Improving cancer therapy with new p53-activating agents
Supervisor of Rute de Fátima Azevedo Pinheiro
Master in Oncology, ICBAS, University of Porto (Master)
2018 - 2019 Chalcone derivatives: promising starting points for the discovery of new diarylpentanoids with p53-MDM2/X inhibitory activity
Co-supervisor of Joana Filipa Duarte Almeida
 Master in Pharmaceutical Chemistry, FFUP, University of Porto (Master)
2018 - 2019 Developing new anticancer drug candidates by targeting p53
Co-supervisor of Joana Maria Alves da Silva
 Master in Biomedical Engineering - Clinical Engineering, University of Minho (Master)
2018 - 2019 Development of lipid nanoparticles containing LEM2 for topical treatment of skin cancer
Co-supervisor of Rafaela Faria Malta
 Master in Pharmaceutical Technology, FFUP, University of Porto (Master)
2018 - 2019 Search for activators of mutant p53 with antitumoral activity
Supervisor of Hugo Miguel Carvalho Glória
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2018 - 2019 Searching for new therapeutic opportunities in skin cancer prevantion and treatment by targeting p53
Supervisor of Rita do Carmo Ribeiro
Estágio da Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2015 - 2019 New anticancer drug candidates by targeting p53/p73: structural studies and nanodelivery systems. PD/BD/114046/2015
Supervisor of Ana Sara de Carvalho Gomes
PhD in Biotechnology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2019 Drugging p53-impaired tumors : impact of new small molecules targeting p73 and mutant p53. FCT: SFRH/BD/96189/2013
Supervisor of Sara Gomes Moreira
PhD in Biotechnology (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2018 Targeting p53 in anticancer therapy: searching for new small molecule activators
Supervisor of Beatriz Sampaio da Silva
Master in Oncology, ICBAS, University of Porto (Master)
2017 - 2018 Pharmacological and functional study of BRCA1 mutants
Supervisor of Ana Margarida Casanova Malta
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2017 - 2018 Targeting p53: Searching for new potential anticancer drugs
Supervisor of Maria João Malheiro
Curso em Anatomia Patológica, Escola Superior de Saúde do Porto, IPP (Degree)
2017 - 2018 Searching for new therapeutic options in melanoma treatment
Supervisor of Telma Filipa Lopes dos Santos Costa
 Estágio da Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2013 - 2018 Targeted regulation of PKC signaling pathway: Searching for new therapeutic strategies against cancer. FCT - SFRH/BD/87109/2012
Supervisor of Cláudia Sofia Santos Bessa
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2017 Discovery of MANIO-1: a new selective p53 activator
Supervisor of Ana Beatriz Sousa Pinto
Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2016 - 2017 Reactivation of mutant p53 by SLMP53-1: effect on tumor metabolism
Supervisor of Isabel Câmara Furtado
 Estágio da Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2015 - 2016 Reactivation of p53: Searching for new small molecules anticancer candidates
Supervisor of Joana Cristina Barbosa Loureiro
Master in Biochemistry, Faculty of Sciences / ICBAS, University of Porto (Master)
2015 - 2016 Identification of selective activators of protein kinase C isoforms from a library of semi-synthetic derivatives of natural diterpenoids isolated from Plectranthus grandidentatus
Supervisor of Bryan da Silva Fernandes
Master in Molecular Biology, Biotechnology and Bio Entrepreneurship in Plants, University of Minho (Master)
2015 - 2016 Development of a microbial system for functional and pharmacological studies of p53 mutants
Supervisor of Mariana Lopes Constante
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2015 - 2016 Search for mutant BRCA1 reactivators: from yeast to tumor cells
Supervisor of Marta Morsiani
Corso di Laurea Magistrale in Farmacia, Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Italia (Degree)
2015 - 2016 Role of mutant p53 in cancer: the yeast assay in the search for mutant p53 reactivators
Supervisor of Patrycja Trzaska
Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Warsaw, Poland (Degree)
2015 - 2016 Development of yeast cell systems to study BRCA proteins
Supervisor of Sofia Ferraz
Licenciatura em Biologia da Faculdade de Ciências da Universidade do Porto (Degree)
2012 - 2016 Targeting p53 in Cancer: From Innovative Yeast Screening Strategies to New Drugs. FCT - SFRH/BD/78971/2011
Supervisor of Joana Oliveira Gama Soares
PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2015 Targeting p53 family in cancer: Search for inhibitors of the p53/p73 interaction with MDMs
Supervisor of Helena Isabel Nogueira Ramos Rocha
 Master in Bioengineering - Molecular Biotechnology, Faculty of Engineering, University of Porto (Master)
2014 - 2015 Developing synthetic tools to image and modulate the activity of Carboxyl terminus of Hsc70-interacting protein (CHIP)
Co-supervisor of Mariana Cristina de Sá Cardoso dos Santos
 Master in Biochemistry, Faculty of Sciences / ICBAS, University of Porto (Master)
2014 - 2015 Protein kinase c isoforms: modulation by small-molecules and their impact on mutant p53
Supervisor of Ana Rita Fernandes dos Santos
Licenciatura em Biologia da Faculdade de Ciências da Universidade do Porto (Degree)
2014 - 2015 p73: a promising target in cancer therapy
Supervisor of Helena Isabel Nogueira Ramos Rocha
Mestrado Integrado em Bioengenharia, Ramo Biotecnologia, da Faculdade de Engenharia da Universidade do Porto (Master)
2013 - 2014 Molecular and pharmacological regulation of p53 mutants: from yeast to human cells
Supervisor of Liliana Sofia Gomes Raimundo
 Master Degree in Oncology, ICBAS, University of Porto (Master)
2013 - 2014 Searching for new potential small-molecule modulators of pro-apoptotic proteins using the yeast-based screening assay
Supervisor of Verónica Sofia Salazar e Costa
 Master in Pharmaceutical Chemistry, FFUP, University of Porto (Master)
2013 - 2014 Design and synthesis of new xanthone derivatives as potential disruptors of p53:MDM2 interaction
Co-supervisor of Agostinho Lemos
 Master in Pharmaceutical Chemistry, FFUP, University of Porto (Master)
2013 - 2014 Synthesis of caspases modulators with flavonic scaffold
Co-supervisor of Joana P. Moreira
 Master in Pharmaceutical Chemistry, FFUP, University of Porto (Master)
2013 - 2014 Estudos funcionais e farmacológicos de mutantes da proteína p53 humana utilizando a levedura como modelo celular
Supervisor of Joana Machado
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2013 - 2014 Searching for inhibitors of the p53 interaction with MDM2 and MDMX: from yeast to human cells
Supervisor of Helena Isabel Nogueira Ramos Rocha
 Estágio da Licenciatura em Bioquímica da Faculdade de Ciências/Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (Degree)
2013 - 2014 Síntese de calconas com potencial atividade na p53
Co-supervisor of Carlos Fernandes
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2013 - 2014 Estudo do envolvimento da via das caspases na atividade antitumoral da frutalina nativa e recombinante
Co-supervisor of Liliana Patrícia Sousa Gonçalves
 Mestrado Integrado em Engenharia Biomédica – Ramo Engenharia Clínica da Universidade do Minho (Master)
2010 - 2014 Development of new yeast-based assays to study p53 family proteins: identification of new small molecule modulators. FCT - SFRH/BD/64184/2009
Supervisor of Mariana Valência Castanheira Ferreira Leão
PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2013 Studying p53 family proteins: search for small-molecule modulators
Supervisor
 Master in Biochemistry, Faculty of Sciences / ICBAS, University of Porto (Master)
2012 - 2013 Implementação de um ensaio com células de levedura para a pesquisa de ativadores da caspase-3 humana
Supervisor of Joana Coelho
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Implementação de um ensaio com células de levedura para a pesquisa de ativadores da caspase-6 humana
Supervisor of Tânia Coelho
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Utilização da levedura Saccharomyces cerevisiae na pesquisa de ativadores da p53 e de inibidores da interação p53-MDM2/MDMX
Supervisor of Raquel de Oliveira Pereira
 Unidade Curricular de Projeto II do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Using yeast to study p53 mutants: regulation by protein kinase c isoforms
Supervisor of Hugo Bacelo
 Mestrado Integrado de Bioengenharia do Instituto de Ciências Biomédicas Abel Salazar, Faculdade de Engenhara da Universidade do Porto (Degree)
2012 - 2013 Synthesis of alkylated derivatives of a bioactive natural flavone targeting caspases
Supervisor of Ana Catarina de Almeida Alves Pereira
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Síntese de calconas com potencial atividade na p53
Co-supervisor of Daniela Pereira
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Synthesis of Prenylchalcones with potential activity in the p53-MDM2 interaction
Co-supervisor of Sylvie Carvalho
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Otimização hit-to-lead de um inibidor da interação p53-MDM2
Co-supervisor of Carolina Sobral
Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2012 - 2013 Elucidação dos mecanismos moleculares subjacentes ao efeito citotóxico da frutalina nativa e recombinante em células tumorais humanas
Co-supervisor of Sofia Emanuela Soares Mendonça
 Mestrado Integrado em Engenharia Biomédica – Ramo Engenharia Clínica da Universidade do Minho (Degree)
2011 - 2012 Utilização da levedura Saccharomyces cerevisiae como modelo biológico na pesquisa farmacológica de inibidores da interação p53-MDM2
Supervisor of Diana Patrícia Pereira da Costa
 Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2011 - 2012 Pesquisa de compostos moduladores da interação P53-MDM2 utilizando levedura como modelo celular
Supervisor of Samara Nunes Salomão
Unidade Curricular de Projeto II do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2008 - 2012 Characterization of mitochondrial stress pathways in neurodegeneration using Drosophila melanogaster as a model system. FCT - SFRH/BD/41682/2007
Co-supervisor of Maria Inês de Castro
 PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2011 Using yeast to study the role of ceramide pathway in the regulation of mammalian protein kinase C isoformas
Supervisor of Cláudia Bessa
 Master in Molecular Genetics from the University of Minho (Master)
2010 - 2011 Utilização da levedura como sistema de produção de uma proteína da cápside de um novo norovirus
Supervisor of Edite Dias
 Master in Molecular Genetics from the University of Minho (Master)
2008 - 2011 Use of yeast in the study of mammalian proteins involved in cell survival/death processes and in the screening of their pharmacological modulators. FCT - SFRH/BD/36066/2007
Supervisor of Isabel Cristina Loureiro Coutinho
PhD in Pharmaceutical Sciences (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2011 A new approach for the study of individual PKC isoform modulation of Bcl-2/Bax mediated cell survival: searching for apoptosis based-therapeutic agents. FCT - SFRH/BD/23774/2005
Co-supervisor of Rui Filipe Silva
PhD in Biological Sciences (PhD)
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2009 - 2010 Análise fenotípica e pesquisa de supressores da proteína humana LRRK2/mutante no sistema celular da levedura
Supervisor of Joana Soares
 Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2009 - 2010 Pesquisa de compostos moduladores da actividade de membros da família das caspases, utilizando a levedura como modelo celular
Supervisor of Cristina Jorge de Carvalho Baptista
 Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2008 - 2009 Utilização da levedura como modelo celular no estudo de proteínas apoptóticas humanas e na pesquisa de seus moduladores farmacológicos
Supervisor of Andreína Pereira
 Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2006 - 2007 Estudo dos mecanismos de regulação da proteína supressora tumoral p53 pelas diferentes isoformas da PKC e pela proteína MDM2: Utilização da levedura como modelo celular
Supervisor of Elisabete de Castro Cavaleiro
 Unidade Curricular de Projeto I do Mestrado Integrado em Ciências Farmacêuticas da FFUP (Degree)
2005 - 2006 Utilização da levedura na pesquisa de moduladores selectivos para isoformas individuais da cínase C de proteínas (PKC) de mamíferos e elucidação do seu envolvimento na regulação da apoptose
Supervisor of Gil Pereira
 Estágio em Biologia Aplicada da Escola de Ciências da Universidade do Minho (Degree)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/05/17 - Current 6º Encontro de Biotecnologia Microbiana e Farmacêutica (2022/05/17 - 2022/05/17) Universidade do Porto Faculdade de Farmácia, Portugal
2016 - Current III BiotechHealth Annual Symposium – Spotting The Differences: Emerging technologies in Health Sciences (2016 - 2016)
Symposium
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/03/06 - 2023/03/06 MODEL ORGANISMS: POWERFUL TOOLS IN HEALTH RESEARCH (2023/03/06 - 2023/03/06) Universidade do Porto Faculdade de Farmácia, Portugal
2020 - 2020 FCT Summer School 2020 - “Interdisciplinary approaches to control infectious diseases and cancer” (2020 - 2020)
Other (Member of the Organising Committee)
2019/04/30 - 2019/04/30 6º Encontro de Biotecnologia Microbiana e Farmacêutica (2019 - 2019)
Congress
 Universidade do Porto Faculdade de Farmácia, Portugal
2019 - 2019 Microbiology, Immunology and Oncobiology: Interdisciplinary approaches to control infectious diseases and cancer (2019 - 2019)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2019 - 2019 Advanced training course “Model organisms in human disease: the right organism for a specific question” (2019 - 2019)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 “Drug Delivery in Regenerative Medicine: playing with complexity” (Speaker: Doutor Lino Ferreira) (2018 - 2018)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 “SpermBoost - improving sperm quality with translational research and novel applications for known molecules” (Speaker: Doutor Marco Alves) (2018 - 2018)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 V BiotechHealth Annual Symposium – Science&Co.: Bridging the Gap (2018)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 “Minding the gap between the pleasure of science-making and the duties of business leadership” (Speaker: Doutora Joana Correia) (2017 - 2017)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2017 IV BiotechHealth Annual Symposium – Spotting The Differences: Biotechnology Driving Precision Medicine (2017)
Symposium
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016 5º Encontro de Biotecnologia Microbiana e Farmacêutica (2016 - 2016)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2016 “Biomolecule analytics using microscale thermophoresis” (Speaker: Dra. Aileen Justies) (2016 - 2016)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2016 “Development of an immunotherapy against infection by multiresistant bacteria” (Speaker: Doutor Pedro Madureira) (2016 - 2016)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2016 “Biopharmaceuticals development: from discovery to first in man flow and issues” (Speaker: Prof Doutor Manuel Carrondo) (2016 - 2016)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 4º Encontro de Biotecnologia Microbiana e Farmacêutica (2015 - 2015)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 III Jornadas de Saúde Pública e Farmacoterapia (2015 - 2015)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 2nd Annual Symposium of BiotechHealth (2015 - 2015)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2015 “From idea to market” (Speaker: Doutora Daniela Couto) (2015 - 2015)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 “Red Biotech: finding a meaning for life” (Speaker: Prof Doutor Jorge Gonçalves) (2015 - 2015)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 “Entrepreneurship in the field of regenerative medicine: challenges and opportunities” (Speaker: Prof Doutor José Domingos Santos) (2015 - 2015)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2015 “New Drug Development in Portugal” (Speaker: Doutor Lyndon Christopher Wright) (2015 - 2015)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 3º Encontro de Biotecnologia Microbiana e Farmacêutica (2014 - 2014)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 II Jornadas de Saúde Pública e Farmacoterapia (2014 - 2014)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 1st Annual Symposium of BiotechHealth (2014 - 2014)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014 “Development of an advanced therapy medicinal product (ATMP): ECBIO's case study for rheumatoid arthritis” (Speaker: Prof Doutor Miguel Santos) (2014 - 2014)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 “From science to market: the challenging pathway of drug development” (Speaker: Prof Doutor Sérgio Simões) (2014 - 2014)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 “NANOBODIES®, an example of antibody biotechnology” (Speaker: Doutor Miguel Conde) (2014 - 2014)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2014 1st Annual Symposium of BiotechHealth (2014 - 2014)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014 III Jornadas de Saúde Pública e Farmacoterapia (2014 - 2014)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2013 2º Encontro de Biotecnologia Microbiana e Farmacêutica (2013 - 2013)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2013 II Jornadas de Saúde Pública e Farmacoterapia (2013 - 2013)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2012 1º Encontro de Biotecnologia Microbiana e Farmacêutica (2012 - 2012)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2012 - 2012 I Jornadas de Saúde Pública e Farmacoterapia (2012 - 2012)
Congress (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2011 Advanced training course "Yeast: A Valuable Research Tool” (2011 - 2011)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2011 “O Farmacêutico Comunitário e o seu Papel na Promoção da Saúde” (Speaker: Dra Paula Sílvia Raposo) (2011 - 2011)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2011 “Contributos da epidemiologia para compreender as doenças oncológicas enquanto problema de saúde pública” (Speaker: Prof. Doutor Nuno Lunet) (2011 - 2011)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2011 "Microbiologia na indústria das bebidas" (Speaaker: Doutor Pedro Rodrigues) (2011 - 2011)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2011 "Microorganisms in the design and engineering of novel enzymes for textile applications" (Speaaker: Doutora Rita Araújo) (2011 - 2011)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2010 “Métodos contraceptivos versus Aborto” (Speaker: Prof. Doutor Belmiro Patrício) (2010 - 2010)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2010 “Toxicodependência” (Speaker: Dr. José Gonzalez) (2010 - 2010)
Conference (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Member of the jury in the doctoral thesis "Production of compatible solutes using the cyanobacterium Synechocystis sp. PCC 6803 as photoautotrophic chassis"
Thesis Member
 Eunice Ferreira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 Member of the jury in the doctoral thesis "NOVAS ESPIRO-ß-LACTAMAS COM POTENTE DUPLA ATIVIDADE ANTIMICROBIANA"
Thesis Member
 Nuno Alexandre Guerreiro Alves (PhD)
Universidade de Coimbra, Portugal
2021 Unravelling the oncogenic functions and regulation of the most conserved p53 isoform, ¿160p53: a study in cancer cells and transgenic mice
(Thesis) Main arguer
 Ana Catarina Campos Ramalho (Other)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021 Ativadores da p53 em ensaios cl nicos para o tratamento de cancro
(Thesis) Main arguer
 Jo o Pedro Jorge Santana (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 Member of the jury in the doctoral thesis "New tools for enzymatic characterization and inhibitor screening: postMichaelis_Menten kinetic analysis",
Thesis Member
 Maria Filipa Sanches Pinto (PhD)
Universidade do Porto, Portugal
2020 Member of the jury in the Master thesis "2D versus 3D Models: Effect of CM-272 on Prostate Cancer Cell Lines"
(Thesis) Main arguer
 Filipa Moreira Silva (Master)
2016 Member of the jury in the doctoral thesis "Preparation and Preclinical Evaluation of New Triterpenoid Compounds"
(Thesis) Arguer
 Bruno Miguel Ferreira Gonçalves (PhD)
Universidade de Coimbra, Portugal
2016 Member of the jury in the doctoral thesis "Preparation and Pre-clinical Evaluation of New Pentacyclic Triterpenoids"
Thesis Member
 Vanessa Isabel da Silva Mendes! (PhD)
Universidade de Coimbra, Portugal
2016 Member of the jury in the doctoral thesis "Cis and Trans, p53 and NF-¿B rules of transactivation"
(Thesis) Arguer
 Vasundhara Sharma (PhD)

Association member

Society Organization name Role
2022 - Current Associate Editors in Frontiers in Oncology – Cancer Molecular Targets and Therapeutics

Committee member

Activity description
Role 		Institution / Organization
2024 - Current Mestrado em Microbiologia em Saúde
Member
 University of Porto, Faculty of Pharmacy, Portugal
2013 - Current Member of the Directive Board of The Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth)
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Conference scientific committee

Conference name Conference host
2023 - 2023 X BiotechHealth Annual Symposium
2023 - 2023 7th Symposium of the MSc in Oncology”, IPO
2022/02/14 - 2022/02/15 6th SYMPOSIUM OF THE MSc IN ONCOLOGY
2022 - 2022 Microrganismos na Saúde e na Doença FFUP
2022 - 2022 IX BiotechHealth Annual Symposium, Resilient Science in a Changing World ICBAS/FFUP/i3S
2021 - 2021 8th BiotechHealth Annual Symposium
2020 - 2020 4th SYMPOSIUM OF THE MSc IN ONCOLOGY IPO PORTO, Main Auditorium
2020 - 2020 VII BiotechHealth Annual Symposium – From bench to bedside: found in translation ICBAS/FFUP/i3S
2020 - 2020 4th symposium of the MSc in oncology IPO-PORTO
2019 - 2019 VI BiotechHealth Annual Symposium, Upgrading Your Next Big Idea ICBAS/FFUP/i3S
2018 - 2018
2017 - 2017
2016 - 2016

Consulting

Activity description Institution / Organization
2023 - Current Startup Beat Therapeutics

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Responsible for the Curricular Unit of Microbial Biotechnology of the Integrated Master Degree in Pharmaceutical Sciences, of FFUP (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2015 - Current Teaches in the curricular unit "In Vitro Pharmacology Methods" of the Doctoral Program in Experimental and Clinical Pharmacology and Toxicology, of FMUP Universidade do Porto Faculdade de Medicina, Portugal
2013 - Current Responsible for the Curricular Units: Scientific Meetings I of the Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) PhD in Biotechnology (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - Current Teaches in the curricular unit "Bioassays in Drug Discovery" of the Master Degree in Pharmaceutical Chemistry of FFUP (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2013 - Current Responsible for the Curricular Units: Scientific Meetings II of the Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) PhD in Biotechnology (Ensino básico 3º ciclo) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - Current Responsible for the Curricular Units: Scientific Meetings III of the Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) PhD in Biotechnology Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - Current Responsible for the Curricular Units: Scientific Meetings IV of the Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) PhD in Biotechnology Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012 - Current Teaches in the Master Degree in Quality Control of the FFUP (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2010 - Current Responsible for the Public Health Curricular Unit of the Integrated Master Degree in Pharmaceutical Sciences, of the FFUP Public Health (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2020 Responsible for the Industrial Microbiology Curricular Unit of the Integrated Master Degree in Pharmaceutical Sciences, of FFUP
2009 - 2014 Doctoral Program in Occupational Safety and Health (DEMSSO) Universidade do Porto Faculdade de Engenharia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2022 - Current GEN Biotechnology - Editor
2021 - Current Pharmacological Research - Consulting Editor
2021 - Current Frontiers in Oncology – Cancer Molecular Targets and Therapeutics - Associate Editor
2021 - 2022 Cancers - Guest Editor MDPI AG
2021 - 2022 Pharmaceuticals - Guest Editor MDPI
2020 - 2021 Cancers - Guest Editor (2072-6694) MDPI AG

Other jury / evaluation

Activity description Institution / Organization
2020 - Current Member of the panel of evaluators of the "la Caixa" Fellowships Programme
2021 - 2021 Member of the panel of evaluators of the scientific projects of the National Science Centre Poland
2020 - 2021 Reviewer of the Science Fund of the Republic of Serbia Republika Srbija, Serbia
2015 - 2015 Member of the panel of evaluators of the scientific projects of Czech Science Foundation Grantová agentura Ceské republiky, Czech Republic
2015 - 2015 Member of the panel of evaluators of the Pfizer/SCML 2015 award
2007 - 2012 Member of the panel of evaluators of “Projetos Pluridisciplinares” from U.Porto Universidade do Porto, Portugal
Distinctions

Award

2024 Beat Therapeutics, 23rd Edition Young Entrepreneur Award
2023 InnoStars 2023 award, EIT Health, European Institute of Innovation and Technology
EIT Health, Germany
2023 BIP Acceleration Program 2023 award
2023 BIP Ignition Program 2023 award
2023 UI-CAN "Empreende@Universidade" 2023 - COMPETE
2023 8th Edition InnoStars Awards, EIT Health – European Institute of Innovation and Technology
2022 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte (LPCC) -Grant
2021 BIP PROOF 2020/2021
Universidade do Porto, Portugal
2021 Best oral presentation - Health Sciences - IJUP 2021
Universityy of Porto, Portugal
2021 Best poster presentation - Health Sciences- IJUP 2021
2021 BBIT20 - Programa de Apoio à Inovação (PAI)
2021 Best Flash Communication - The 7th International Electronic Conference on Medicinal Chemistry
2021 British Journal of Pharmacology Annual Prize for Early Career Researcher 2021
2020 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte (LPCC) - Grant
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2020 The 6th International Electronic Conference on Medicinal Chemistry (ECMC 2020) - Best Presentation Award
2020 SIFFUP – Simpósio de Investigação da FFUP - best presentation award
Universidade do Porto Faculdade de Farmácia, Portugal
2019 Best poster - 12º Edition IJUP 2019
Universidade do Porto, Portugal
2019 Best communication - Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto (SIFFUP) 2019
Universidade do Porto, Portugal
2019 BIP PROOF 2019
Universidade do Porto, Portugal
2019 Best research - 1º Encontro Nacional de Jovens Investigadores em Oncologia 2019”, Liga Portuguesa Contra o Cancro
Liga Portuguesa Contra o Cancro, Portugal
2019 Best Master Thesis in Medicinal Chemistry
Sociedade Portuguesa de Química, Portugal
2018 Best Innovation Project - MED-IDEAS Cancer NORTEXCEL 2018
NORTEXCEL2020, Portugal
2018 Best presentation - ECMC-4: the 4th International Electronic Conference on Medicinal Chemistry 2018
Pharmaceuticals and the Organizing Committee of ECMC-4 , United Kingdom
2017 Best Poster - 18th International Conference on MedicinalChemistry & Targeted Drug Delivery 2017
2017 “Targeting the p53 pathway” - ESMO-EACR
European Society for Medical Oncology, Switzerland
2011 Best Poster - XX Porto Cancer Meeting
2008 Best Work IN Health Sciences
2007 Best Poster - Cell Physiology, Biochemistry and Molecular Biology Symposium do MICRO'07 BIOTEC'07-XXXIII JPG
2007 “Yeast as a new approach to study the regulation of p53 activity by individual protein kinase C isoforms” - 15th ECDO Euroconference on Apoptosis
European Commission Marie Sklodowska-Curie Actions, Belgium
2004 Prémio Professor Doutor José Vale Serrano
Ordem dos Farmaceuticos, Portugal
1999 Prémio Engenheiro António de Almeida
Fundação Engenheiro António de Almeida, Portugal
1999 Prémio Nuno Salgueiro
Universidade do Porto Faculdade de Farmácia, Portugal
1999 Prémio Carlos Richter
Universidade do Porto Faculdade de Farmácia, Portugal
1998 Prémio Professor Doutor José Ferreira Vale Serrano
Ordem dos Farmaceuticos, Portugal

Other distinction

1999 Bolsa de doutoramento
Fundação para a Ciência e a Tecnologia, Portugal
1991 Bolsa de Mérito
Fundação Calouste Gulbenkian, Portugal