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Sandra Nunes is PhD student in the Cancer Biology and Epigenetics Group of the Portuguese Oncology Institute of Porto - Research Center and in Molecular Oncology Unit in CIEMAT, Madrid, Spain. She has published 11 articles in peer-reviewed journals. She develops her work in the field of basic and translational medicine, namely in cancer epigenetics and immunology.
Identification

Personal identification

Full name
Sandra Nunes

Citation names

  • Nunes, Sandra P.

Author identifiers

Ciência ID
0B1C-8388-4843
ORCID iD
0000-0003-4466-037X

Email addresses

  • sandra22nunes@gmail.com (Professional)
  • sandraisabel.pinto@externos.ciemat.es (Professional)
  • sandra.pinto.nunes@ipoporto.min-saude.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Proficiency (C2) Advanced (C1)
French Elementary (A2) Elementary (A2) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2020/01/01 - 2023/10/31
Ongoing
 Ciências Biomédicas (Doutoramento)
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Centro de Investigaciones Energéticas Medioambientales y Tecnológicas, Spain

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Bladder Cancer: Tackling Epigenetic Players and Immuno-Oncology" (THESIS/DISSERTATION)
2019/09/01 - 2019/10/31
Concluded
 ERASMUS+ (Graduado)
Centro de Investigaciones Energéticas Medioambientales y Tecnológicas, Spain
2016/09/19 - 2018/10/31
Concluded
 Oncologia (Mestrado)
Major in Oncologia Molecular
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies Cancer Biology and Epigenetics Group of Portuguese Oncology Institute of Porto." (THESIS/DISSERTATION)
 19
2013/09/23 - 2016/07/22
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Study of resveratrol antioxidant effects in H2O2-induced oxidative stress in human epithelial colorectal adenocarcinoma (Caco-2) cells UCBIO – REQUIMTE, Laboratory of Applied Chemistry, Faculty of Pharmacy, University of Porto" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2019/01/02 - 2019/12/31 Research Trainee (Research) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2015/09/25 - 2017/03/31 Research Trainee (Research) UCBIO – REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2019/09/01 - Current Understanding Bladder Cancer through genetically engineered mouse models of preclinical application
CB16/12/00228
PhD Student Fellow
Centro de Investigaciones Energéticas Medioambientales y Tecnológicas, Spain
 Centro de Investigación Biomédica en Red de Cáncer
Ongoing
2018 - Current Uncovering novel prognostic and predictive epigenetic biomarkers in malignant testicular germ cell tumors
POCI-01-0145-FEDER-29043
Research Fellow
Grupo de Epigenética e Biologia do Cancro - Centro de Investigação do Instituto Português de Oncologia do Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/04/07 - Current Assessment and validation of a panel of methylation-based biomarkers in cell-free DNA for detection of recurrent first primary and second primary cancers
CI-IPOP-74-2016
Research Fellow
Grupo de Epigenética e Biologia do Cancro - Centro de Investigação do Instituto Português de Oncologia do Porto, Portugal
 Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação
Ongoing
Outputs

Publications

Journal article
  1. Carolina Rubio Martin; José Avendaño Ortiz; Raquel Ruiz-Palomares; Viktoriya Karaivanova; Omaira Alberquilla; Rebeca Sánchez-Domínguez; José Carlos Casalvilla-Dueñas; et al. "Toward Tumor Fight and Tumor Microenvironment Remodeling: PBA Induces Cell Cycle Arrest and Reduces Tumor Hybrid Cells’ Pluripotency in Bladder Cancer". Cancers (2022): https://www.mdpi.com/2072-6694/14/2/287.
    10.3390/cancers14020287
  2. Lodewijk, Iris; Nunes, Sandra P.; Henrique, Rui; Jerónimo, Carmen; Dueñas, Marta; Paramio, Jesús M.. "Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy". Clinical Epigenetics 13 1 (2021): http://dx.doi.org/10.1186/s13148-021-01046-0.
    10.1186/s13148-021-01046-0
  3. Sandra P. Nunes; Rui Henrique; Carmen Jerónimo; Jesús M. Paramio. "DNA Methylation as a Therapeutic Target for Bladder Cancer". Cells 9 8 (2020): 1850-1850. https://doi.org/10.3390/cells9081850.
    10.3390/cells9081850
  4. Saudade André; Sandra P. Nunes; Fernanda Silva; Rui Henrique; Ana Félix; Carmen Jerónimo. "Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer". International Journal of Molecular Sciences 21 8 (2020): 2715-2715. https://doi.org/10.3390/ijms21082715.
    10.3390/ijms21082715
  5. Vera Constâncio; Sandra Nunes; Rui Henrique; Carmen Jeronimo; Carmen Jerónimo. "DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types". Cells (2020): https://www.mdpi.com/2073-4409/9/3/624.
    10.3390/cells9030624
  6. Nunes; Diniz; Moreira-Barbosa; Constâncio; Silva; Oliveira; Soares; et al. "Subtyping Lung Cancer Using DNA Methylation in Liquid Biopsies". Journal of Clinical Medicine 8 9 (2019): 1500. http://dx.doi.org/10.3390/jcm8091500.
    10.3390/jcm8091500
  7. Rui Henrique; Sandra P. Nunes; Carmen Jerónimo. "MSH2 Expression and Resistance to Cisplatin in Muscle-invasive Bladder Cancer: A Mix of Progress and Challenges". European Urology 75 2 (2019): 251-252. https://doi.org/10.1016%2Fj.eururo.2018.11.014.
    10.1016/j.eururo.2018.11.014
  8. Lobo, J.; Nunes, S.P.; Gillis, A.J.M.; Barros-Silva, D.; Miranda-Gonçalves, V.; van den Berg, A.; Cantante, M.; et al. "XIST-promoter demethylation as tissue biomarker for testicular germ cell tumors and spermatogenesis quality". Cancers 11 9 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073413264&partnerID=MN8TOARS.
    10.3390/cancers11091385
  9. Constâncio, V.; Nunes, S.P.; Moreira-Barbosa, C.; Freitas, R.; Oliveira, J.; Pousa, I.; Soares, M.; et al. "Early detection of the major male cancer types in blood-based liquid biopsies using a DNA methylation panel". Clinical Epigenetics 11 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075909374&partnerID=MN8TOARS.
    10.1186/s13148-019-0779-x
  10. Salta, Sofia; P. Nunes, Sandra; Fontes-Sousa, Mário; Lopes, Paula; Freitas, Micaela; Caldas, Margarida; Antunes, Luís; et al. "A DNA Methylation-Based Test for Breast Cancer Detection in Circulating Cell-Free DNA". Journal of Clinical Medicine 7 11 (2018): 420. http://dx.doi.org/10.3390/jcm7110420.
    10.3390/jcm7110420
  11. Nunes, Sandra P.; Moreira-Barbosa, Catarina; Salta, Sofia; Palma de Sousa, Susana; Pousa, Inês; Oliveira, Júlio; Soares, Marta; et al. "Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women". Cancers 10 10 (2018): 357. http://dx.doi.org/10.3390/cancers10100357.
    10.3390/cancers10100357
  12. Maria Prata-Sena; Bruno M. Castro-Carvalho; Sandra Nunes; Bento Amaral; Paula Silva. "The terroir of Port wine: Two hundred and sixty years of history". Food Chemistry 257 (2018): 388-398. https://doi.org/10.1016%2Fj.foodchem.2018.03.014.
    10.1016/j.foodchem.2018.03.014
  13. Sandra Nunes; Francesca Danesi; Daniele Del Rio; Paula Silva. "Resveratrol and inflammatory bowel disease: the evidence so far". Nutrition Research Reviews 31 01 (2017): 85-97. https://doi.org/10.1017%2Fs095442241700021x.
    10.1017/s095442241700021x
Thesis / Dissertation
  1. Nunes, Sandra P.. "Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies". Master, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018. https://repositorio-aberto.up.pt/bitstream/10216/116511/2/296664.pdf.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11/23 Inhibiting epigenetic machinery as a therapeutic approach for bladder cancer, Poster Presentation 3rd ASEICA Educational Symposium
ASEICA (Online, Spain)
2021/10/14 Effects of G9a/DNMTs inhibition on tumor microenvironment in bladder cancer, Poster presentation II ASPIC-ASEICA International Meeting – Current Trends in Precision Medicine in Cancer
ASPIC ASEICA (Online, Spain)
2020/12/13 Inhibiting epigenetic machinery as a therapeutic approach for bladder cancer III Young Researchers Meeting
CIBERONC (Online, Spain)
2019/12/20 Bladder cancer: tackling epigenetic players and immuno-oncology
Abel Salazar Biomedical Sciences Institute - University of Porto (Porto, Portugal)
2019/09/24 DNA methylation-based prognostic biomarkers for breast cancer in liquid biopsies 1st Meeting of Young Investigators in Oncology
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2019/02/13 DNA methylation as a tool for lung cancer subtyping in liquid biopsies 12th Meeting of Young Researchers of the University of Porto
University of Porto (Porto, Portugal)
2019/02/04 Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women Tracking Cancer: Detection and Monitoring, from Diagnosis to Therapy
European Association for Cancer Research (Barcelona, Spain)
2018/11/15 Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women 22nd annual meeting of Portuguese Society of Genetics, CIM FMUP
Universidade do Porto Faculdade de Medicina (Porto, Portugal)
2018/05/10 Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies, selected for a highlighted poster session 3rd ASPIC International Congress, Gulbenkian Foundation
Associação Portuguesa de Investigação em Cancro (Lisboa, Portugal)
2018/05/07 Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies 2nd Symposium of Master in Oncology, Portuguese Institute of Oncology of Porto, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/02/01 - 2019/05/31 Methylation-based signature for detection and prognosis of prostate cancer Biochemistry (Master)
Universiteit Antwerpen, Belgium

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/09/01 - 2017/09/07 Organization of Science & Wine – from terroir to glass (2017/09/01 - 2017/09/07)
Congress (Member of the Organising Committee)
 Associação das Empresas de Vinho do Porto (AEVP), Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/09/01 - 2020/10/24 Functions A, B, C and D for animal care and experimentation
Other
Centro de Investigaciones Energéticas Medioambientales y Tecnológicas, Spain
2019/01/04 - 2019/01/17 Course of Immunology. Classification obtained 18 out of 20. Immunology
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2017/10/31 - 2017/12/14 Basic Level Course of French
Other
 Basic Level Course of French
Mais Idiomas, Portugal
2017/11/16 - 2017/11/17 Attendance to the 5th Advanced Course of Gynecologic Oncology
Congress
 5th Advanced Course of Gynecologic Oncology
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2017/06/30 - 2017/06/30 Basic Life Support Course
Other
 Basic Life Support Course
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2017/04/21 - 2017/04/23 Attendance to the V AEICBAS Biomedical Congress
Congress
 V AEICBAS Biomedical Congress
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/10/10 - 2016/10/11 Introduction to data analysis & image processing with MATLAB Course Introduction to data analysis & image processing with MATLAB
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/04/08 - 2016/04/08 Attendance to the III Conference on Biochemistry - Biochemists though the world
Conference
 III Conference on Biochemistry - Biochemists though the world
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/07/24 - 2015/07/24 Attendance to the GABBA Annual Symposium 2015 – Science Society and Utopia
Conference
 GABBA Annual Symposium 2015 – Science Society and Utopia
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

Society Organization name Role
2017 - Current Portuguese Association for Cancer Research (ASPIC)
2017 - Current European Association for Cancer Research (EACR)
Distinctions

Award

2019 Meeting bursary to attend "Tracking Cancer: Detection and Monitoring, from Diagnosis to Therapy" in Barcelona
European Association For Cancer Research, United Kingdom

Other distinction

2018 Winner of the Liga Portuguesa Contra o Cancro/Pfizer fellowship with the project ”DNA methylation as a prognostic biomarker for breast cancer in liquid biopsies”
Liga Portuguesa Contra o Cancro, Portugal