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Miguel Aroso completed the PhD in Biochemistry in 2014 at University of Aveiro. Has a master's degree in Advanced Biomolecular Methods from University of Aveiro and a degree in Microbiology at the Catholic University of Portugal-Faculty of Biotechnology. Published 20 articles in international journals (H-index of 12, Google Scholar) and 1 Book chapter. Supervised 4 MSc dissertations, and 1 PhD thesis (ongoing). Has received 4 awards. Participated as a researcher in 4 completed projects and currently participates in 4 ongoing projects (2 international and 2 national). His main research interests are related to improving available neuronal modulation methods via electrical stimulation. He is particularly devoted to the characterization of the neuron-astrocyte crosstalk under electrical stimulation. To accomplish that he resources to high-resolution electrophysiological recordings with microelectrode arrays, functional analysis of neural cells activity via optical microscopy and development of cutting-edge tools to improve in vitro technologies. He is also commited to the development of innovative open-source image processing computational tools for data analysis.
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Identification

Personal identification

Full name
Miguel Ângelo Mouta Martins Aroso

Citation names

  • Aroso, Miguel

Author identifiers

Ciência ID
0C10-852F-2212
ORCID iD
0000-0002-3118-0185

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Elementary (A2) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2014
Concluded
 Bioquímica (Doutoramento)
Universidade de Aveiro, Portugal
"Characterisation of ZG16p, a unique mammalian lectin from pancreatic zymogen granules " (THESIS/DISSERTATION)
 cum laude
2007
Concluded
 Mestrado em Métodos Biomoleculares Avançados (Mestrado)
Universidade de Aveiro, Portugal
"Proteomics of lachrymal glands: study of the action of Ecstasy" (THESIS/DISSERTATION)
 Aprovado
2003
Concluded
 Microbiologia (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 14 (catorze)
Affiliation

Science

Category
Host institution 		Employer
2019/05/01 - 2025 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/05/01 - 2019/04/30 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01/01 - 2017/04/30 Postdoc (Research) Universidade de Aveiro Instituto de Biomedicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012/04/01 - 2012/04/30 Invited Assistant (Polytechnic Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2011/10/21 - 2011/10/22 Tutor (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2009/10/01 - 2011/09/30 Invited Assistant (University Teacher) Universidade de Aveiro Escola Superior de Saúde de Aveiro, Portugal
2008/10/01 - 2009/09/30 Tutor (University Teacher) Universidade de Aveiro Escola Superior de Saúde de Aveiro, Portugal
2009/05/01 - 2009/05/30 Tutor (Polytechnic Teacher) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal

Others

Category
Host institution 		Employer
2015/01/11 - 2015/09/29 Voluntary PostDoc Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2009/09/01 - 2014/12/22 PhD Student (FCT Scholarship) Universidade de Aveiro Departamento de Biologia, Portugal
Universidade de Aveiro Departamento de Biologia, Portugal
2008/01/01 - 2009/08/31 Researcher Assistant Universidade de Aveiro Departamento de Biologia, Portugal
2008 - 2008 Researcher Assistant Universidade de Aveiro Departamento de Biologia, Portugal
2006/04/01 - 2007/03/01 Researcher Assistant New York Medical College, Dpt. of Microbiology and Immunology, United States
2004/02/01 - 2004/07/31 Researcher Assistant Institute of Food Research National Collection of Yeast Culture, United Kingdom
Projects

Grant

Designation Funders
2019/05/01 - 2025/04/30 Advancing voltage sensitive dye imaging with novel image processing tools and applications to evaluate spinal cord regenerative therapies
CEECIND/03415/2017/CP1392/CT0003
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/05/01 - 2019/04/30 Novel protocols and computational analysis tools for voltage sensitive dye imaging (VSDi) applied to regenerative therapies on spinal cord injury
SFRH/BPD/123261/2016
Post-doc Fellow
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/09/01 - 2013/08/31 Characterisation of ZG16p, a unique mammalian lectin from pancreatic zymogen granules
SFRH/BD/48722/2008
PhD Student Fellow
Universidade de Aveiro Departamento de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2023/01/01 - 2025/12/31 Neuromorphic devices for adaptive real-time neuromodulation in brain electrical stimulation therapies
HR22-00189
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Consejo Superior de Investigaciones Científicas, Spain

Universidade do Porto, Portugal
Fundação 'la Caixa'
Ongoing
2022/01/31 - 2025/12/30 Improving Deep Brain Stimulation in Parkinson's Disease with Personalized Electrophysiological Biomarkers and Data-Driven Stimulation Strategies
MB-12-2022
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Santa Casa da Misericórdia de Lisboa
Ongoing
2022/08/14 - 2025/08/13 Cytoskeletal and membrane adaptations of stretched neurons: from tension-induced growth to traumatic brain injury
DRI/India/0336/2020
10.54499/DRI/India/0336/2020
Researcher
Instituto de Astrofísica e Ciências do Espaço, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 Storing and recalling biological Memories with Neuromorphic Electronics
PTDC/NAN-MAT/4093/2021
10.54499/PTDC/NAN-MAT/4093/2021
Researcher
Universidade do Porto Instituto de Física dos Materiais-Instituto de Nanociência e Nanotecnologia, Portugal

Universidade do Porto Faculdade de Ciências, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Astrofísica e Ciências do Espaço, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Dissecting the mechanisms underlying tension-driven axon growth.
EXPL/BIA-CEL/0717/2021
10.54499/EXPL/BIA-CEL/0717/2021
Researcher
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/03/19 - 2023/03/18 Mind The Gap: decoding and bridging somatosensory information in the spinal cord
PTDC/EMD-EMD/31540/2017
10.54499/PTDC/EMD-EMD/31540/2017
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 Uncovering the mechanistic assembly and function of actin ring networks in axonal biology and pathology.
PTDC/MED-NEU/28623/2017
Researcher
Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

International Iberian Nanotechnology Laboratory, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/23 - 2022/02/18 New Active Medical Implants
PTDC/EEI-EEE/32348/2017
Researcher
Universidade do Porto, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

International Iberian Nanotechnology Laboratory, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/12/31 Biogenesis of peroxisomes: Identification and characterization of the molecular machinery required for the growth and division of peroxisomes
PTDC/BIA-BCM/71932/2006
Research Fellow
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Sousa, Sara Castro; Aroso, Miguel; Veríssimo, Eduardo; Brites, Pedro; Aguiar, Paulo; Sousa, Monica M; Lopes, CDF. "Tension-driven axon elongation triggers cytoskeleton and membrane remodelling". Paper presented in IUBMB-EMBO Focused Meeting On Emerging Concepts Of The Neuronal Cytoskeleton (6th Edition), Santa Cruz, 2023.
Conference poster
  1. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Socodato, Renato; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; et al. "Rho GTPases in the spotlight: unveiling methamphetamine's effects on neuronal remodeling in the hippocampus". Paper presented in Neuroscience 2023, 2023.
  2. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "A Tripartite Microfluidic Device with Integrated Microelectrodes to Study the Neuron-Astrocyte Crosstalk". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  3. Castro, Domingos; Aroso, Miguel; A. Pedro Aguiar; David B. Grayden; Aguiar, Paulo. "Disrupting unwanted neuronal oscillations with closed-loop". Paper presented in NER IEEE 2023, 11th International IEEE EMBS Conference on Neural, 2023.
  4. Ana Filipa Terceiro; Andrea C. Lobo; Canedo, T.; Lia Carvalhais; Aroso, Miguel; Mafalda Sousa; Socodato, Renato; et al. "Methamphetamine-induced modulation of RhoGTPases in hippocampal neurons and microglia". Paper presented in Neuro-immune interactions in health and disease organised by the Hertie Foundation and the Federation of European Neuroscience Societies, 2023.
  5. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; Socodato, Renato; et al. "Methamphetamine-induced modulation of RhoGTPases in hippocampal neurons and microglia (Presented by A. Terceiro)". Paper presented in n FENS-Hertie Winter School on Neuro-Immune Interactions in Health and Disease, 2023.
  6. Castro, Domingos; Aroso, Miguel; A. Pedro Aguiar; David B. Grayden; Aguiar, Paulo. "Disrupting pathological neuronal oscillations with closed-loop stimulation in vitro". Paper presented in Nature Conference - Technologies for Neuroengineering 2022, 2022.
  7. Silva, SC; Castro, Domingos; MATEUS, JOSÉ C; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "Electrical Stimulation of Astrocytes and its Impact on Astrocytic Calcium Signaling". Paper presented in VI Symposium of the Portuguese Glia Network, 2022.
  8. Terceiro, Ana F.; Lobo, Andrea; Canedo, Teresa; Carvalhais, Lia; Aroso, Miguel; Sousa, Mafalda; Magalhães, Ana; et al. ""Methamphetamine remodelling of hippocampal neurons is orchestrated via cdc42 pathway (Presented by A. Terceiro)". Paper presented in VI Symposium of the Portuguese Glial Network, 2022.
  9. Domingos Leite de Castro; Aroso, Miguel; Aguiar, A. Pedro; David B. Grayden; Aguiar, Paulo. Corresponding author: Domingos Leite de Castro. "Disrupting periodic neuronal synchrony with closed-loop stimulation in vitro". Paper presented in Cosyne 2022, 2022.
  10. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. Corresponding author: Catarina Dias. "Bio/electronic interfaces for neuroprosthetics". Paper presented in 3rd Condensed Matter Physics National Conference, 2022.
  11. Lobo, Andrea; Ana Filipa Terceiro; Lia Carvalhais; Aroso, Miguel; Mafalda Sousa; Ana Magalhães; Aguiar, Paulo; Relvas, João; Summavielle, Teresa. "Methamphetamine remodelling of hippocampal neurons is orchestrated via cdc42 pathway". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  12. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. "A neuromorphic system for real-time feedback stimulation of neuronal populations". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  13. Mateus JC; Lopes, CDF; Aroso, Miguel; Costa AR; Gerós, Ana; Meneses J; Faria P; et al. "New insights into the mechanisms regulating axonal development and maturation". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  14. Aroso, Miguel; Domingos Castro; Sara Silva; Leonor Sá; Aguiar, Paulo. Corresponding author: Aroso, Miguel. "Astrocytes are activated by direct electrical stimulation in the physiological range of neuronal activity". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  15. Lopes, CDF; Catarina Ricardo; Maria Ribeiro; José Mateus; Aroso, Miguel; Aguiar, Paulo. Corresponding author: Aguiar, Paulo. "Dissecting the regulatory effects of neuronal electrical activity on mitochondria axonal transport dynamics". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience - SPN2021, 2021.
  16. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. Corresponding author: Catarina Dias. "A bio-electronic memristive interface for real-time coupling of neuronal populations". Paper presented in 4th International Conference on Memristive Materials, Devices & Systems (MEMRISYS 2021), 2021.
  17. Sara Castro Sousa; Aroso, Miguel; Tiago Silva; Lopes, CDF; Pedro Brites; Aguiar, Paulo; Sousa, Monica M. "A microfluidic platform enabling live imaging of cytoskeleton dynamics and transport of axon elongation driven by physiological stretch". Paper presented in The EMBO Workshop Axons 2021: Structure and Function, 2021.
  18. Catarina Dias; Domingos Castro; Aroso, Miguel; João Ventura; Aguiar, Paulo. "Real-time adaptive coupling between neuronal populations in a hybrid bio-electronic interface using memristors". Paper presented in Nature Conference- Technologies for Neuroengineering, 2021.
  19. Sara Patrícia Castro Sousa; Aroso, Miguel; Tiago Silva; Cátia D F Lopes; Pedro Brites; Paulo Aguiar; Mónica M Sousa. "A microfluidic platform for tension-driven axon elongation". Paper presented in SFN - Global Connectomme - A Virtual Event, 2021.
  20. Sara Castro Sousa; Aroso, Miguel; Cátia D F Lopes; Paulo Aguiar; Mónica M Sousa. "STRETCH: Uncovering the molecular players in tension-driven axon growth". Paper presented in Neurofluidics 2019, 2019.
  21. Aroso, Miguel; Sara C Silva; Paulo Aguiar. "Enlightening the neuron-astrocytes interaction in the electrophysiological domain: astrocytic calcium waves in response to electrical stimuli". Paper presented in i3S Annual Meeting, 2019.
  22. Aroso, Miguel; Paula Sampaio; Paulo Aguiar. "A new computational tool for analysing neuronal activity from voltage and calcium imaging". Paper presented in SPN Meeting, 2019.
  23. Sara Costa Silva; Paulo Aguiar; Aroso, Miguel. "Assessing Functional Activity of Astrocytes by Calcium Imaging: Astrocytic Calcium Signals and the Electrophysiological Microenvironment". Paper presented in SPN Meeting 2019, 2019.
  24. Aroso, Miguel; Cátia Lopes; Paula Sampaio; Paulo Aguiar. "ToolVIA – Toolbox for Voltage-Imaging Analysis". Paper presented in 2nd NEUBIAS Conference, 2018.
  25. Wang, Haiying; Zheng, Huiru; Azuaje, Francisco. "Protein analysis of protein complexes in zymogen granules of the exocrine pancreas by BN-PAGE". Paper presented in 4th EuPA Scientific Meeting & 6th Rede ProCura Meeting, 2010.
    10.1109/bibm.2013.6732716
  26. R. Vitorino; Aroso, Miguel; A. Caseiro; M. Schrader; F. Amado. "Endogeneous peptides from rat salivary glands". Paper presented in 5th Portuguese ProCura Meeting on Proteomics and Mass Spectrometry; 1st International Congress on Analytical Proteomic, 2009.
  27. Aroso, Miguel; M. G. Lázaro; C. Rinn; R. Vitorino; F. Amado; M. Schrader. "Suborganellar proteomics: Getting a grip on pancreatic zymogen granule membrane proteins". Paper presented in 5th Portuguese ProCura Meeting on Proteomics and Mass Spectrometry; 1st International Congress on Analytical Proteomics, 2009.
  28. Aroso, Miguel; Rui Vitorino; Francisco Amado; Michael Schrader. "Accessing the Proteome of Zymogen Granules". 2008.
    10.1109/izsbc.2000.829220
  29. Aroso, Miguel; Rui Vitorino; Armando Caseiro; Helena Carmo; Félix Carvalho; José A.Duarte; Francisco M.L. Amado. "Proteomics of lachrymal gland: study of sympathomimetic stimulation after sub-lethal ecstasy administration". Paper presented in 4th Annual Meeting of the Portuguese Proteomics Network (ProCura) and 1st Meeting of the Portuguese National Mass Spectrometry Network (RNEM), 2007.
  30. Warwick B. Dunn; Georgina A. Lacey; Marianne Defernez; Aroso, Miguel; Marie Brown; Fred A. Mellon; Donald A. MacKenzie; Douglas B. Kell; Ian N. Roberts. "Metabolic footprinting for studying the relationship of genetic variation and metabolic activity in yeast.". Paper presented in Consortium for Post Genome Science Conference, 2006.
  31. Lacey G.; Aroso, Miguel; MacKenzie D.; Fuller, L.J.; James S.; Bond C.; Defernez M.; et al. "Metabolic profiling - applications in food safety and technology.". Paper presented in Metabolic Profiling: Pathways in Discovery, 2004.
  32. Lacey G.; Aroso, Miguel; MacKenzie D.; Fuller L.; James S.; Bond C.. "Genome rearrangement and comparative metabolomics". Paper presented in The Consortium for Post-Genome Science 2nd Conference: Genomes to Systems, 2004.
Journal article
  1. Domingos L Castro; Miguel Aroso; A Pedro Aguiar; David B Grayden; Paulo Aguiar. "Disrupting abnormal neuronal oscillations with adaptive delayed feedback control". eLife (2024): https://doi.org/10.7554/eLife.89151.
    10.7554/eLife.89151
  2. Neto, Estrela; Leitão, Luís; Mateus, José C.; Sousa, Daniela M.; Alves, Cecília J.; Aroso, Miguel; Monteiro, Ana C.; et al. "Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling". Cell & Bioscience 12 1 (2022): http://dx.doi.org/10.1186/s13578-022-00864-w.
    10.1186/s13578-022-00864-w
  3. Dias, Catarina; Castro, Domingos; Aroso, Miguel; Ventura, João; Aguiar, Paulo. "Memristor-Based Neuromodulation Device for Real-Time Monitoring and Adaptive Control of Neuronal Populations". ACS Applied Electronic Materials 4 5 (2022): 2380-2387. http://dx.doi.org/10.1021/acsaelm.2c00198.
    Open access • Published • 10.1021/acsaelm.2c00198
  4. JC Mateus; CDF Lopes; M Aroso; AR Costa; A Gerós; J Meneses; P Faria; et al. "Bidirectional flow of action potentials in axons drives activity dynamics in neuronal cultures". Journal of Neural Engineering (2021): https://doi.org/10.1088/1741-2552/ac41db.
    10.1088/1741-2552/ac41db
  5. Ana Freitas; Miguel Aroso; António Barros; Miriam Fernández; Eduardo Conde-Sousa; Marina Leite; Eva Daniela Carvalho; et al. "Characterization of the Striatal Extracellular Matrix in a Mouse Model of Parkinson’s Disease". Antioxidants 10 7 (2021): 1095-1095. https://doi.org/10.3390/antiox10071095.
    10.3390/antiox10071095
  6. Freitas, Ana; Aroso, Miguel; Rocha, Sara; Ferreira, Rita; Vitorino, Rui; Gomez-Lazaro, Maria. "Bioinformatic analysis of the human brain extracellular matrix proteome in neurodegenerative disorders". European Journal of Neuroscience 53 12 (2021): 4016-4033. http://dx.doi.org/10.1111/ejn.15316.
    10.1111/ejn.15316
  7. Leite, Marina; Marques, Miguel S.; Melo, Joana; Pinto, Marta T.; Cavadas, Bruno; Aroso, Miguel; Gomez-Lazaro, Maria; Seruca, Raquel; Figueiredo, Ceu. "Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions". Cells 9 2 (2020): 513. http://dx.doi.org/10.3390/cells9020513.
    10.3390/cells9020513
  8. Ferreira, Rita; Neuparth, Maria; Nogueira-Ferreira, Rita; Magalhães, Sandra; Aroso, Miguel; Bovolini, José; Lara Santos, Lúcio; et al. "Exercise Training Impacts Cardiac Mitochondrial Proteome Remodeling in Murine Urothelial Carcinoma". International Journal of Molecular Sciences 20 1 (2018): 127. http://dx.doi.org/10.3390/ijms20010127.
    10.3390/ijms20010127
  9. Rocha, Sara; Freitas, Ana; Guimaraes, Sofia; Vitorino, Rui; Aroso, Miguel; Gomez-Lazaro, Maria. "Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson’s Disease". Antioxidants 7 1 (2017): 1. http://dx.doi.org/10.3390/antiox7010001.
    10.3390/antiox7010001
  10. Magalhães, S.; Aroso, M.; Roxo, I.; Ferreira, S.; Cerveira, F.; Ramalheira, E.; Ferreira, R.; Vitorino, R.. "Proteomic profile of susceptible and multidrug-resistant clinical isolates of Escherichia coli and Klebsiella pneumoniae using label-free and immunoproteomic strategies". Research in Microbiology 168 3 (2017): 222-233. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009210876&partnerID=MN8TOARS.
    10.1016/j.resmic.2016.12.002
  11. Aroso, M.; Ferreira, R.; Freitas, A.; Vitorino, R.; Gomez-Lazaro, M.. "New insights on the mitochondrial proteome plasticity in Parkinson's disease". Proteomics - Clinical Applications 10 4 (2016): 416-429. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959422268&partnerID=MN8TOARS.
    10.1002/prca.201500092
  12. Bonekamp, N.A.; Grille, S.; Cardoso, M.J.; Almeida, M.; Aroso, M.; Gomes, S.; Magalhaes, A.C.; et al. "Self-Interaction of Human Pex11pß during Peroxisomal Growth and Division". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872153510&partnerID=MN8TOARS.
    10.1371/journal.pone.0053424
  13. Caseiro, A.; Barros, A.; Ferreira, R.; Padrão, A.; Aroso, M.; Quintaneiro, C.; Pereira, A.; et al. "Pursuing type 1 diabetes mellitus and related complications through urinary proteomics". Translational Research (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885514549&partnerID=MN8TOARS.
    10.1016/j.trsl.2013.09.005
  14. Rinn, C.; Aroso, M.; Prüssing, J.; Islinger, M.; Schrader, M.. "Modulating zymogen granule formation in pancreatic AR42J cells". Experimental Cell Research 318 15 (2012): 1855-1866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863777946&partnerID=MN8TOARS.
    10.1016/j.yexcr.2012.05.025
  15. Richer, L.M.; Aroso, M.; Contente-Cuomo, T.; Ivanova, L.; Gomes-Solecki, M.. "Reservoir targeted vaccine for lyme borreliosis induces a yearlong, neutralizing antibody response to OspA in white-footed mice". Clinical and Vaccine Immunology 18 11 (2011): 1809-1816. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455164830&partnerID=MN8TOARS.
    10.1128/CVI.05226-11
  16. Gómez-Lázaro, María; Rinn, Cornelia; Aroso, Miguel; Amado, Francisco; Schrader, Michael. "Proteomic analysis of zymogen granules". Expert Review of Proteomics 7 5 (2010): 735-747. http://dx.doi.org/10.1586/epr.10.31.
    10.1586/epr.10.31
  17. Borta, H.; Aroso, M.; Rinn, C.; Gomez-Lazaro, M.; Vitorino, R.; Zeuschner, D.; Grabenbauer, M.; Amado, F.; Schrader, M.. "Analysis of low abundance membrane-associated proteins from rat pancreatic zymogen granules". Journal of Proteome Research 9 10 (2010): 4927-4939. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957346850&partnerID=MN8TOARS.
    10.1021/pr100052q
  18. Ivanova, L.; Christova, I.; Neves, V.; Aroso, M.; Meirelles, L.; Brisson, D.; Gomes-Solecki, M.. "Comprehensive seroprofiling of sixteen B. burgdorferi OspC: Implications for Lyme disease diagnostics design". Clinical Immunology 132 3 (2009): 393-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651155750&partnerID=MN8TOARS.
    10.1016/j.clim.2009.05.017
  19. Del Rio, B.; Dattwyler, R.J.; Aroso, M.; Neves, V.; Meirelles, L.; Seegers, J.F.M.L.; Gomes-Solecki, M.. "Oral immunization with recombinant Lactobacillus plantarum induces a protective immune response in mice with lyme disease". Clinical and Vaccine Immunology 15 9 (2008): 1429-1435. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649091939&partnerID=MN8TOARS.
    10.1128/CVI.00169-08
  20. Pope, G.A.; MacKenzie, D.A.; Defernez, M.; Aroso, M.A.M.M.; Fuller, L.J.; Mellon, F.A.; Dunn, W.B.; et al. "Metabolic footprinting as a tool for discriminating between brewing yeasts". Yeast 24 8 (2007): 667-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548300162&partnerID=MN8TOARS.
    10.1002/yea.1499
Online resource
  1. Aroso, Miguel; Ferreira, Rita; Freitas, Ana; Vitorino, Rui; Gomez-Lazaro, Maria. Frontispiece: New insights on the mitochondrial proteome plasticity in Parkinson's disease. 2016. http://dx.doi.org/10.1002/prca.201670047.
    10.1002/prca.201670047
  2. Aroso, M.; Agricola, B.; Hacker, C.; Schrader, M.. Addendum to the paper: Proteoglycans support proper granule formation in pancreatic AR42J cells. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973652572&partnerID=MN8TOARS.
    10.1007/s00418-015-1339-x
  3. Aroso, Miguel. The secretory lectin ZG16p. 2011.
    http://dx.doi.org/10.3998/panc.2011.17
  4. Aroso, Miguel. Rab8. 2011.
    http://dx.doi.org/
Preprint
  1. Miguel Aroso; Domingos Castro; Sara Costa Silva; Paulo Aguiar. "Bringing astrocytes into the spotlight of electrical brain stimulation". 2024. https://doi.org/10.1101/2024.02.28.582466.
    10.1101/2024.02.28.582466
  2. Domingos Leite de Castro; Miguel Aroso; A. Pedro Aguiar; David B. Grayden; Paulo Aguiar. "Adaptive delayed feedback control disrupts unwanted neuronal oscillations and adjusts to network synchronization dynamics". 2022. https://doi.org/10.1101/2022.07.05.498735.
    10.1101/2022.07.05.498735
  3. Mateus, JC; Lopes, CDF; Aroso, M; Costa, AR; Gerós, A; Meneses, J; Faria, P; et al. "In vitro neuronal networks show bidirectional axonal conduction with antidromic action potentials effectively depolarizing the soma". 2021. http://europepmc.org/abstract/PPR/PPR293629.
    10.1101/2021.03.07.434278
  4. Dias, Catarina; Castro, Domingos; Aroso, Miguel; Ventura, João; Aguiar, Paulo. "A memristor-based neuromodulation device for real-time monitoring and adaptive control ofin vitroneuronal populations". 2021. http://dx.doi.org/10.1101/2021.05.20.444941.
    10.1101/2021.05.20.444941
Thesis / Dissertation
  1. Aroso, Miguel Ângelo Mouta Martins. "Characterisation of ZG16p, a unique mammalian lectin from pancreatic zymogen granules". PhD, 2015. http://hdl.handle.net/10773/14099.
  2. Aroso, Miguel Ângelo Mouta Martins. "Proteómica das glândulas lacrimais : estudo da acção da ecstasy". Master, 2007. http://hdl.handle.net/10773/2995.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/06/01 Chatting with neurons: novel approaches to analyze function and communication in neuronal cultures using a combination of microfluidics and microelectrode arrays. XVI Meeting of the Portuguese Society for Neuroscience
(Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01/01 - Current Unravelling the mysteries of astrocyte-neuron communication: the role of electrical signaling on astrocytic activity
Co-supervisor of Sara Cristina da Costa e Silva
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10/15 - 2022/07/29 Computational Tools to Analyse Electrophysiological Data in Deep Brain Stimulation
Co-supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2020/10/05 - 2021/10/04 Characterization of neuronal network dynamics on microelectrode arrays: assessing the effect of temperature and the activity profile of long-term recordings
Supervisor of João Tiago dos Santos Palma
 Bioengenharia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/10/01 - 2020/07/10 Development of image analysis tools for the characterization of astrocytic calcium waves in controlled electrophysiological conditions
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2018/10/01 - 2019/11/12 Assessing Functional Activity of Astrocytes by Calcium Imaging: How do Astrocytes Respond to the Electrophysiological Microenvironment?
Supervisor
 Bioestatística e Bioinformática Aplicadas à Saúde (Master)
Instituto Politécnico do Porto, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/04/08 - 2019/04/09 Workshop on Neuroengineering - 3rd edition: Decoding Neural Information Hands-on practical sessions on basic lab techniques in neuroengineering. I was responsible for the pratical session: Imaging neuronal activity with calcium dyes (2019/04/08 - 2019/04/09)
Workshop (Other)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/04/09 - 2018/04/10 Workshop on Neuroengineering: Electroceuticals Hands-on practical sessions on basic lab techniques in neuroengineering. I was responsible for the pratical session: Imaging neuronal activity with voltage sensitive dyes (VSD) (2018/04/09 - 2018/04/10)
Workshop (Other)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/04/01 - 2017/04/28 The functioning of the human organism is governed by various events that we are now beginning to understand. The BioMedicine area uses different approaches and model organisms to study all the details of the phenomena that occur both in health and in disease. This exhibition shows different ways used by researchers at the University of Aveiro to visualise and represent these events. And there are several techniques that make visible what was previously not perceptible (for example, microscopy, electrophoresis, molecular modelling, among others). (2017/04/01 - 2017/04/28)
Exhibition (Co-organisor)
 Fábrica Centro Ciência Viva de Aveiro, Portugal
2010/09/08 - 2010/09/10 Hands-on Proteomics Course 2010 (2010/09/08 - 2010/09/10)
Workshop (Co-organisor)
 Universidade de Aveiro Centro de Espectrometria de Massa, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2017/09/03 - 2017/09/05 NEUBIAS is a unique network of bioimage analysts in Europe, aiming at strengthening the bridge between life science, computer science and digital image
Workshop
 2nd Training School for Early Career Researchers (TS4)
Göteborgs universitet Sahlgrenska Akademin, Sweden
2017/04/27 - 2017/04/28 Workshop on Neuroengineering - Revealing, Repairing and Enhancing Brains
Workshop
 Workshop on Neuroengineering - Revealing, Repairing and Enhancing Brains
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/04/19 - 2017/04/21 Introduction to data analysis and image processing with MATLAB
Workshop
 Introduction to data analysis and image processing with MATLAB
Instituto Nacional de Engenharia Biomédica, Portugal
2016/10/10 - 2016/10/11 Data analysis and image processing with MATLAB
Other
 Introduction to data analysis and image processing with MATLAB
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/04/11 - 2016/04/15 Principles of optical microscopy including: fundamentals of light microscopy and digital imaging; principles of wide-field and confocal fluorescence microscopy; live cell imaging and advanced microscopy applications; new cell imaging technologies.
Workshop
 8th course on Optical Microscopy Imaging for Biosciences
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/11/05 - 2015/11/06 International Symposium in applied Bioimaging
Meeting
 Bioimaging 2015 - 4th International Symposium in applied Bioimaging - the preclinical challenge in 3D
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/11/04 - 2015/11/04 Microscopy image processing and data extraction with ImageJ
Workshop
 Hands-on Workshop on "Microscopy image processing and data extraction with ImageJ"
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/03/13 - 2012/03/15 Three-day course provided an overview on the basics of confocal microscopy, multicolor, 3D- and time lapse imaging as well as spectral imaging, photobleaching (FRAP, FLIP, FLAP) and photoactivation techniques. A combination of lectures and intense daily hands-on practicals was followed by discussion and breakout sessions, during which participants were able to learn the basics of confocal microscopy and good imaging practices.
Other
 EMBL Introductory course: Confocal Microscopy
European Molecular Biology Laboratory, Germany

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/02/25 - 2014/02/25 Clinical Biotechnology II Ciências Biomédicas (Doutoramento) Universidade de Aveiro, Portugal
2013/03/05 - 2013/03/05 Clinical Biotechnology II Ciências Biomédicas (Licenciatura) Universidade de Aveiro, Portugal

Mentoring / Tutoring

Topic Student name
2024/02/01 - 2024/06/01 Erasmus internship Marcos Oriol Pagonabarraga
2023/10/15 - 2024/02/15 Erasmus internship Babette Furchtbar
Distinctions

Award

2022 Prémio Mantero Belard
Santa Casa da Misericórdia de Lisboa, Portugal
2021 SPN Travel Grant
Sociedade Portuguesa de Neurociências, Portugal
2018 Short-Term Scientific Mission - COST Action CA15124

Other distinction

2018 Contracted Researcher (Research)
Associação para a Inovação e Desenvolvimento da FCT, Portugal
2016 Postdoc (Research)
Associação para a Inovação e Desenvolvimento da FCT, Portugal
2009 PhD Student (FCT Scholarship)
Associação para a Inovação e Desenvolvimento da FCT, Portugal