???global.info.a_carregar???
Identification

Personal identification

Full name
Inês Morgado Martins

Citation names

  • Martins, Inês
  • Inês Morgado Martins

Author identifiers

Ciência ID
0C1A-2D11-8EAC
ORCID iD
0000-0003-0457-1700

Email addresses

  • minesmorgadom@gmail.com (Personal)

Addresses

  • Hallerstrasse 91, Top 1, 6020, Innsbruck, Innsbruck, Austria (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Elementary (A2) Elementary (A2) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2022/10/01 - 2023/01/30
Ongoing
 CLIC1 - Clinical Investigator Certification (Level 1) (Outros)
Major in Investigação Clínica
Universidade de Aveiro Associação para a Formação Profissional e Investigação, Portugal
2015/12/01 - 2022
Ongoing
 PhD Programme in Experimental Biology and Biomedicine (Doutoramento)
Major in Neuroscience and Disease
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
"Assessing the role of nucleocytoplasmic transport mechanisms in Machado-Joseph disease" (THESIS/DISSERTATION)
2017 - 2017
Concluded
 FELASA Category B certified researcher for carrying out animal experiments (Outros) (Outros)
Major in Experimentação Animal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010 - 2012
Concluded
 Mestrado em Biomedicina Molecular (Mestrado)
Major in Biomedicina Molecular
Universidade de Aveiro, Portugal
"Evolution and functional relevance of Ataxin-3 paralogues" (THESIS/DISSERTATION)
 17
2010
Concluded
 Ciências biomédicas - Menor em Biomedicina molecular (Licenciatura)
Universidade de Aveiro, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2020/03/01 - Current Researcher (Research) Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
2013/05/15 - 2015/02/28 Research Trainee (Research) Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Germany
Institute of Medical Genetics and Applied Genomics, University Hospital Tübingen, Germany
2011/03/01 - 2011/03/30 Research Trainee (Research) Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal

Others

Category
Host institution 		Employer
2015/12/01 - 2020/02/28 PhD Student CNC.IBILI, Portugal
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
2011/09/01 - 2012/07/11 Master student Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2020/03/23 - 2021/12/30 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2015/12/01 - 2020/01/12 Assessing the role of nucleocytoplasmic transport mechanisms in Machado-Joseph disease
PD/BD/114171/2016
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2013/05/15 - 2015/02/28 ITN TreatPolyQ program (Industrial Academic Initial Training Network towards treatment of Polyglutamine Diseases) - Marie Curie Actions
ID: 264508
Research Fellow
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
Outputs

Publications

Conference abstract
  1. Schmidt, Thorsten; Wang, Zijian; Sowa, Anna Sergeevna; Schmidt, Jana; et al.. "Targeting the intracellular localization of Ataxin-3 as novel treatment strategy for Spinocerebellar Ataxia Type 3". Paper presented in 2017 International Congress - International Parkinson and Movement Disorder Society, 2017.
    Published
Conference poster
  1. Inês Morgado Martins; Sowa, Anna Sergeevna; Rufino-Ramos, David; Lobo, Diana Duarte; et al.. "Importin-8 silencing reduces ataxin-3 aggregation, alleviates neuropathology and delays progression of Spinocerebellar Ataxia Type 3 (SCA3)". Paper presented in ICAR2022 - International Congress for Ataxia Research, 2022.
  2. Vasconcelos-Ferreira, Ana; Inês Morgado Martins; Lobo, Diana Duarte; Pereira, Dina; et al.. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph Disease". Paper presented in 2019 International Machado-Joseph Research Disease Conference. Washington, DC. USA, 2019.
  3. Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Faro, Rosario; Miguel M. Lopes; et al.. "Reinstating levels of dysregulated autophagy-associated transcripts alleviates neuropathology and motor impairments of mouse models of Machado-Joseph disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience SPN2019, 2019.
  4. Schmidt, Thorsten; Wang Zijian; Sowa, Anna Sergeevna; Inês Morgado Martins; Teixeira-de-castro, Andreia; Maciel, Patrícia; Antony, Paul; Riess, Olaf. "Towards factors influencing the intracellular localization of ataxin-3". Paper presented in Neuroscience Meeting, Society for Neuroscience, 2014.
  5. Inês Morgado Martins; Sowa, Anna Sergeevna; Riess, Olaf; Schmidt, Thorsten. "Relevance of the nucleocytoplasmic transport proteins in Ataxin-3 aggregation rates". Paper presented in Neurowoche 2014, 2014.
  6. Sowa, Anna Sergeevna; Inês Morgado Martins; Weber, Jonasz Jeremiasz; Huebener, Jeannette; Tricoire, Hervé; Riess, Olaf; Schmidt, Thorsten. "Altered nucleocytoplasmic shuttling of ataxin-3 via transport proteins affects the pathogenesis of SCA3". Paper presented in The National Ataxia Foundation - Annual Membership Meeting 2014, 2014.
  7. Inês Morgado Martins; Dra. Sandra Martins, IPATIMUP - Universidade do Porto, Portugal; et al.. "Evolution of ataxin-3 paralogues and transcriptional pattern of ATXN3L1 in humans". 2013.
Journal article
  1. Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al. "Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3". Molecular Therapy 31 5 (2023): 1275-1292. http://dx.doi.org/10.1016/j.ymthe.2023.04.001.
    10.1016/j.ymthe.2023.04.001
  2. Vasconcelos-Ferreira, Ana; Martins, Inês Morgado; Lobo, Diana; Pereira, Dina; Lopes, Miguel M.; Faro, Rosário; Lopes, Sara M.; et al. "ULK overexpression mitigates motor deficits and neuropathology in mouse models of Machado-Joseph disease". Molecular Therapy 30 1 (2022): 370-387. http://dx.doi.org/10.1016/j.ymthe.2021.07.012.
    Published • 10.1016/j.ymthe.2021.07.012
  3. Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis. "Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders". Brain (2019): http://dx.doi.org/10.1093/brain/awz328.
    Published • 10.1093/brain/awz328
  4. Sowa, Anna Sergeevna; Martin, Elodie; Martins, Inês Morgado; Schmidt, Jana; Depping, Reinhard; Weber, Jonasz Jeremiasz; Rother, Franziska; et al. "Karyopherin a-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3". Proceedings of the National Academy of Sciences 115 11 (2018): E2624-E2633. http://dx.doi.org/10.1073/pnas.1716071115.
    Published • 10.1073/pnas.1716071115
  5. Wang, Zi-Jian; Hanet, Aoife; Weishäupl, Daniel; Martins, Inês M.; Sowa, Anna S.; Riess, Olaf; Schmidt, Thorsten. "Divalproex sodium modulates nuclear localization of ataxin-3 and prevents cellular toxicity caused by expanded ataxin-3". CNS Neuroscience & Therapeutics 24 5 (2018): 404-411. http://dx.doi.org/10.1111/cns.12795.
    10.1111/cns.12795
Newspaper article
  1. Ramalho-Santos, João; Varela Amaral, Sara; Correia, Marta Quatorze; Pereira de Almeida, Luis; et al.. "Uma viagem Rara", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. "Assessing the Role of Nucleocytoplasmic Transport Mechanisms in Machado-Joseph Disease Pathogenesis". PhD, 2023.
  2. Inês Morgado Martins. "Evolution and functional relevance of ATXN3 paralogues". Master, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/9745.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02/17 Importin-8 Silencing Prevents Mutant Ataxin-3 Aggregation And Delays Machado-Joseph Disease Progression SPF Meeting 2021 - Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2018/02/05 Nucleocytoplasmic Transport Proteins as Modulators of Machado-Joseph Disease Pathogenesis SPF Meeting 2018 - Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/09/08 - 2016/09/08 3rd BEB Symposium (2016/09/08 - 2016/09/08)
Symposium (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/07 - Current PubhD Coimbra
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
2019 - Current European researchers night
2017 - Current Brain Awareness Week
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal, Portugal
Distinctions

Other distinction

2022 Travel Grant for attending the Internatinonal Congress for Ataxia Research 2022 (ICAR2022)
National Ataxia Foundation, United States

Friedreichs Ataxia Research Alliance, United States

Ataxia UK, United Kingdom
2019 Travel Grant for attending the EMBO Workshop - Protein quality control: From mechanisms to disease 2019 - Costa de la Calma, Mallorca.
EMBO Press, Germany
2015 Travel grant for poster presentation at the Neurowoche 2014 meeting - Munich/Germany, German Society for Neurology.
Deutsche Gesellschaft für Neurologie, Germany