???global.info.a_carregar???
Identification

Personal identification

Full name
Shirley Sancha

Citation names

  • Sancha, Shirley

Author identifiers

Ciência ID
0D1B-40A0-876A
ORCID iD
0000-0003-3333-7729

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2019
Ongoing
Farmácia (Doutoramento)
Major in Especialidade: Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Amaryllidaceae-type alkaloids as anticancer hit/leads, targeting multidrug resistant cancer cells " (THESIS/DISSERTATION)
2016
Concluded
Mestrado em Química Farmacêutica e Terapêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Avaliação da Atividade Antimicrobiana de Metaboitos Secundários Isolados a Partir de uma Planta usada na Medicina Tradicional Africana" (THESIS/DISSERTATION)
17
2016
Concluded
Química Farmacêutica e Terapêutica (Mestrado)
Major in Sem especialização
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Avaliação da atividade antimicrobiana de metabolitos secundárias isolados a partir de uma planta usada na medicina tradicional africana" (THESIS/DISSERTATION)
17 valores
2012
Concluded
Bioquímica (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"n/a" (THESIS/DISSERTATION)
15
Projects

Contract

Designation Funders
2017/11/01 - 2021/10/31 Amaryllidaceae-type alkaloids as anticancer hit/leads, targeting multidrug resistant cancer cells
SFRH/BD/130348/2017
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/11/01 - 2021/10/31 Amaryllidaceae-type alkaloids as anticancer hit/leads, targeting multidrug resistant cancer cells
SFRH/BD/130348/2017
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Reversão da multirresistência no cancro: compostos derivados de plantas como moduladores da glicoproteína-P P-gp e da proteína de resistência do cancro da mama BCRP e agentes de sensibilidade colateral
PTDC/MED-QUI/30591/2017
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2021/09/30 Reversão da multirresistência no cancro: compostos derivados de plantas como moduladores da glicoproteína-P P-gp e da proteína de resistência do cancro da mama BCRP e agentes de sensibilidade colateral
PTDC/MED-QUI/30591/2017
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Instituto de Investigação do Medicamento
UID/DTP/04138/2019
154706UID
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Sancha, Shirley; Nikoletta Szemerédi; Spengler, Gabriella; Maria-José U. Ferreira (CE1A-3108AC3C). "Amaryllidaceae-type alkaloid derivatives as ABCB1 inhibitors in resistant human colon adenocarcinoma cancer cells and synergistic interaction with doxorubicin". Paper presented in 8thEuChemS Chemistry Congress (ECC8), 2022.
  2. Sancha, Shirley; Gonçalves, Joana; Rodrigues, CMP; Maria-José U. Ferreira. "Phytochemical study of two plant species from Amaryllidaceae family. Cytotoxicity of their main constituents against HCT-116 colon carcinoma cells". Paper presented in iMed.ULisboa Meeting 2021. 16th, 23rd, 30th of June, 7th and 9th of July, 2021.
  3. Sancha, Shirley; Maria-José U. Ferreira. "Generation of small library of Amaryllidaceae-type alkaloids through Isolation and molecular derivatization". Paper presented in 7th Portuguese Young chemists Meeting, Bragança., 2021.
  4. Sancha, Shirley; Silvia Priska; Maria-José U. Ferreira. "Amarallidaceae-type alkaloids from Narcissus and Pancratium species.". Paper presented in Bio Natural Meeting, Universidade Lusófona., 2019.
  5. Sancha, Shirley; Maria-José U. Ferreira. "Amarallidaceae-type alkaloids from Narcissus and Pancratium species. Natural Products in Drug Discovery and Human Health, PSE Meeting 2019, 28-31, July, Lisbon". Paper presented in Natural Products in Drug Discovery and Human Health (NatProDDH), PSE mettings., 2019.
  6. Sancha, Shirley; Maria-José U. Ferreira. "Bioactive alkaloids from species of Amaralidaceae family.". Paper presented in 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting,, 2019.
Journal article
  1. Shirley A.R. Sancha; Simona Dobiasová; Tomáš Nejedlý; Ondrej Strnad; Jitka Viktorová; Maria-José U. Ferreira. "Lycorine and homolycorine derivatives for chemo-sensitizing resistant human ovarian adenocarcinoma cells". Phytomedicine (2024): https://doi.org/10.1016/j.phymed.2024.155460.
    10.1016/j.phymed.2024.155460
  2. Shirley A. R. Sancha; Nikoletta Szemerédi; Gabriella Spengler; Maria-José U. Ferreira. "Lycorine Carbamate Derivatives for Reversing P-glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032061.
    10.3390/ijms24032061
  3. Sancha, Shirley; Gomes, Adriana V.; Loureiro, Joana B.; Saraiva, Lucília; Ferreira, Maria-José U.. Corresponding author: Ferreira, Maria-José U.. "Amaryllidaceae-Type Alkaloids from Pancratium maritimum: Apoptosis-Inducing Effect and Cell Cycle Arrest on Triple-Negative Breast Cancer Cells". Molecules 27 18 (2022): 5759. http://dx.doi.org/10.3390/molecules27185759.
    10.3390/molecules27185759
  4. Kincses, Annamária; Varga, Borisz; Csonka, Ákos; Sancha, Shirley; Mulhovo, Silva; Madureira, Ana Margarida; Ferreira, Maria-José U.; Spengler, Gabriella. "Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria". Phytotherapy Research 32 6 (2018): 1039-1046. http://dx.doi.org/10.1002/ptr.6042.
    10.1002/ptr.6042
  5. Pereira F; Madureira AM; Sancha S; Mulhovo S; Luo X; Duarte A; Ferreira MJ. "Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains.". (2016): http://europepmc.org/abstract/med/26674158.
    10.1016/j.jep.2015.12.009
Thesis / Dissertation
  1. Sancha, Shirley Arnie dos Reis. "Avaliação da atividade antimicrobiana de metabolitos secundárias isolados a partir de uma planta usada na medicina tradicional africana". Master, 2016. http://hdl.handle.net/10451/24984.
  2. Sancha, Shirley Arnie dos Reis. "Avaliação da atividade antimicrobiana de metabolitos secundárias isolados a partir de uma planta usada na medicina tradicional africana". Master, 2016. http://hdl.handle.net/10451/24984.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/07/12 Exploring Amaryllidaceae-type alkaloids and derivatives for overcoming multidrug resistance in cancer EVENTOS 5º Encontro CQUL – “Chemistry: Forging bonds & Summer School”
(Lisboa, Portugal)
2022/07/05 Natural Amaryllidaceae-type alkaloids and derivatives for targeting multidrug-resistant cancer cells XIII iMed.ULisboa Postgraduate Students Meeting
Faculdade Fármacia, Universidade de Lisboa (Lisboa, Portugal)
2022/06/30 Lycorine Derivatives for Reversing P-glycoprotein-mediated Multidrug Resistance in Human Colon Adenocarcinoma Cancer Cells Stratagen's 5th Annual Conference and WG3/4 Training School
(Coimbra, Portugal)
2021/12/20 Amaryllidaceae-type alkaloids: isolation, molecular derivatization, and biological activity WORKSHOP II OVERCOMING MULTIDRUG RESISTANCE
Faculdade Fármacia, Universidade de Lisboa (Lisboa)
2021/07/14 Cytotoxicity activity against HCT-116 colon carcinoma cells of Amaryllidaceae-type Alkaloids XXVII Encontro Nacional da Sociedade Portuguesa de Química
(Braga)
2019/12/18 Bioactive alkaloids for targeting multidrug resistant cancer cells. Workshop: Overcoming Multidrug Resistance.
Natural Products Chemistry Group, Faculty of Pharmacy, University of Lisbon. (Lisboa, Portugal)
2019/06/28 Amaryllidaceae-type alkaloids as anticancer hit/leads, targeting multidrug resistant cancer cells. PhD Course Evaluation - 1st year assessment.
Faculdade Farmácia, Universidade Lisboa (Lisboa, Portugal)