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Carla completed the Integrated Master in Biomedical Engineering in 2010/07 at the University of Coimbra. Later, she was selected as a Ph.D. student for the Ph.D. Program in Experimental Biology and Biomedicine (PDBEB) of the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She received an FCT award to develop her research (2010-2014) at Prof. Rego's lab and in 2015 she concluded her Ph.D. with the thesis entitled "Characterisation of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease". During the Ph.D. she spent 2 years, developing part of the research plan involving stem cells, at Daley's lab, Harvard Medical School, Boston, and at Sandrine Humbert lab, Institut Curie, and Anselm Perrier lab, I-Stem, Paris. In 2015 Carla received a Post-Doctoral fellow grant from the FLAD Grants on Portugal-USA collaborative projects to work on a project entitled "Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells" under the supervision of Prof. Rego. In 2018, Carla got a grant funded by FCT as Principal Investigator with the reference POCI-01-0145-FEDER-029621 - "iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics". Carla has also been enrolled in several teaching activities: 2007 -2010 as an Adjunct Teacher at Instituto Politécnico de Coimbra, Escola Superior de Tecnologia da Saúde de Coimbra, Portugal and 2017-2018 as an Invited Adjunct Teacher at Instituto Politécnico de Castelo Branco, Portugal, where she was responsible for the disciplines of Patologia I (theoric classe: 135 h; 5 ECTS) and Patologia II (theoric classe: 135 h; 5 ECTS). In 2019, she was a tutor (University of Coimbra) in the discipline of Applied Research II for the Integrated Master's degree in Medicine. She has also been a supervisor of several graduate and undergraduate students during lab rotations and was co-supervisor and supervisor of Master theses. In addition, Carla participated as a volunteer at the COVID-19 UC Lab (2020). She was a researcher at the Center for Neuroscience and Cell Biology, University of Coimbra under the DL57/2016 of the Portuguese law for scientific and technological employment from 2019 to 2023. She supervised a small team with a research technician, postdoctoral researcher, and master's student. In the last five years, she has participated in 6 projects. She is a reviewer in 11 journals and guest editor in Methods Collections at JoVE and at a special edition at CELLS. She has also been actively engaged with the science communication office and "Ciência Viva" at the Laboratory in programs for public outreach. In the last years, she collaborated in the organization of 3 events and participated in 24. Also, she has received 8 awards and/or honours. In her professional activities, she has interacted with 58 collaborators and co-authorship of scientific papers. In 2019 Carla had a career break for seven months due to clinical risk during pregnancy followed by maternity leave. Currently, Carla is an assistant researcher at the Multidisciplinary Institute of Ageing, University of Coimbra. She has 18 publications in peer-reviewed international journals and conference abstracts: 8 as the first author, 5 as co-author, 5 as the last author, and 2 book chapters; with 532 citations and an h-index of 12 (Google Scholar [14 in Q1 publications and 8 are in top 10%-CiteScore Scopus].
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Identification

Personal identification

Full name
Carla Maria Nunes Lopes

Author identifiers

Ciência ID
0E10-2833-5AEE
ORCID iD
0000-0002-2543-8821

Email addresses

  • clopes@uc.pt (Professional)
  • carlalopes09@gmail.com (Personal)

Telephones

Telephone
  • 239855760 (Professional)

Addresses

  • Multidisciplinary Institute of Ageing - Portugal University of Coimbra Faculdade de Medicina, Polo I, 3º Piso Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Beginner (A1) Advanced (C1)
Education
Degree Classification
2018/05 - 2018/09
Concluded
 Course in Laboratory Animal Science (FELASA category B) (Pós-Graduação)
Direcção-Geral de Alimentação e Veterinária, Portugal
 Approved
2010/10/01 - 2015/10/02
Concluded
 Experimental Biology and Biomedicine (Doutoramento)
Universidade de Coimbra, Portugal
"Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease" (THESIS/DISSERTATION)
 Approved with praise and distinction
2011/04 - 2013/08
Concluded
 Trainee (Postgraduate Certificate)
Major in Stem cells
Institut Curie, France
2012 - 2013
Concluded
 French course (Curso médio)
Major in Foreign Languages and Literatures
The Training Unit at Institut Curie, France
 A
2011/09 - 2012/02
Concluded
 Advanced Communication Skills in English II (Curso médio)
Major in Foreign Languages and Literatures
Universidade de Coimbra Faculdade de Letras, Portugal
 A
2011/09 - 2011/12
Concluded
 Trainee (Postgraduate Certificate)
Major in Stem cells
Children s Hospital Boston at Waltham, United States
2010 - 2011
Concluded
 Upper Intermediate level of English (Curso médio)
Universidade de Coimbra, Portugal
2005/09 - 2010/07
Concluded
 Engenharia Biomédica (Mestrado integrado)
Universidade de Coimbra, Portugal
"Peripheral and cerebral metabolic features in an animal model of Huntington’s disease expressing full-length mutant huntingtin" (THESIS/DISSERTATION)
 15
2008/12 - 2009/06
Concluded
 Advanced Level English Course (Curso médio)
Major in Foreign Languages and Literatures
International House Coimbra, Portugal
 A
2009 - 2009
Concluded
 Structure -Function correlations in Biomedicine: lessons from the Nervous System (Curso médio)
Major in PhDHS
Universidade de Coimbra Faculdade de Medicina, Portugal
 18
2003 - 2004
Concluded
 Advanced English Conversation Course (Curso médio)
Major in Linguas
International house, Portugal
2003 - 2003
Concluded
 MS Office course (Curso médio)
SadoInformática, Portugal
Affiliation

Science

Category
Host institution 		Employer
2023/01/03 - Current Auxiliary Researcher (Research) University of Coimbra- Multidisciplinary Institute of Ageing, Portugal
Universidade de Coimbra, Portugal
2018/07/05 - 2023/01/02 Contracted Researcher (Research) Centro de Neurociencias e Biologia Celular, Portugal
Centro de Neurociencias e Biologia Celular, Portugal
2015/12/01 - 2017/11/30 Postdoc (Research) Centro de Neurociencias e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2007/09 - 2008/06 Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/07/01 - 2025/02/28 Invited Assistant Professor (University Teacher) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/02 - 2019/07 Tutor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
(...)
2017/09 - 2018/07 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Castelo Branco, Portugal
Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2007/09 - 2011/09 Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Others

Category
Host institution 		Employer
2010/09/01 - 2015/10/02 PhD student Centro de Neurociencias e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Projects

Grant

Designation Funders
2018/07/05 - 2019/01/31 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Post-doc Fellow
Centro de Neurociencias e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013 - 2018 Role of Sirtuin 3 on mitochondrial function and deacetylation of mitochondrial targets: relevance for Huntington's disease.
EXPL/BIM-MEC/2220/2013
Researcher
Centro de Neurociencias e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/12/01 - 2017/11/30 Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells
FLAD LIFE SCIENCE 2020
Post-doc Fellow
Centro de Neurociencias e Biologia Celular, Portugal
 Fundação Luso-Americana
Concluded
2010/11/01 - 2014/10/31 Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease
SFRH / BD / 51192 / 2010
PhD Student Fellow
Centro de Neurociencias e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Fundação para a Ciencia e Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Laboratório para a Investigação Integrativa e translacional em Saúde Populacional
LA/P/0064/2020
Universidade do Porto Instituto de Saúde Pública, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/05 - 2022/07/04 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Principal investigator
Centro de Neurociencias e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2017 Exploring the role of pridopidine on mitochondrial function and dynamics in Huntington's disease models
TEVA Pharmaceutical Industries
Post-doc
Centro de Neurociencias e Biologia Celular, Portugal
 Teva Pharmaceutical Industries Ltd
Concluded

Other

Designation Funders
2007/10 - 2008/05 AGES (Advanced Glycation End Products) and vascular complications in type 2 diabetes
GAPI Medical School
Other
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
Outputs

Publications

Book chapter
  1. Lopes, Carla; Raimundo, Nuno. Corresponding author: Lopes, Carla. "Mitochondria-lysosome crosstalk, in disease and in health". In The Dynamic Nature of Mitochondria: from Ultrastructure to Health and Disease, edited by Taylor & Francis. Boca Raton, United States: CRC Press, 2024.
    In press
  2. Lopes, Carla. "Imaging mitochondrial axonal transport in human induced pluripotent stem cell-derived neurons.". In Mitochondrial Bioenergetics: Methods and Protocols, edited by Paulo Jorge Gouveia Simoes Da Silva Oliveira; Carlos Palmeira. Springer, 2024.
    Accepted
  3. Carmo, Catarina; Naia, Luana; Lopes, Carla; Rego, A. Cristina. "Mitochondrial Dysfunction in Huntington’s Disease". In Advances in Experimental Medicine and Biology, 59-83. Springer International Publishing, 2018.
    10.1007/978-3-319-71779-1_3
Conference abstract
  1. Geva, Michal; Shenkman, Marina; Naia, Luana; Gershoni Emek, Noga; Ly, Philip; Mota, Sandra I; Lopes, Carla; et al. "I13 Pridopidine restores mitochondrial function and decreases er stress which is mediated through the S1R". 2021.
    10.1136/jnnp-2021-ehdn.127
  2. Lopes, Carla. "FIBROBLASTS-DERIVED EXTRACELLULAR VESICLES REVERT SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE STRIATAL NEURONS". Paper presented in ESCI 2021, 2021.
    Published
  3. Lopes, Carla. "Extracellular vesicles cargo as biomarker of mitochondrial dysfunction in Huntington's Disease". Paper presented in ISEV2021, 2021.
    Published • doi.org/10.1111/eci.13567
Conference paper
  1. Geva, Michel; Naia, Luana; Ly, P; Lopes, Carla; Mota, Sandra I; Maranga, Carina; Hayden, Michael; Rego, Ana Cristina. "Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor". Paper presented in HSG 2019, 2019.
    Published
  2. Lopes, Carla; Duarte, Ana I.; Hayden, Michael; Rego, A. Cristina. "Peripheral and cerebral metabolic features in an animal model of Huntington's disease". 2012.
    10.1109/enbeng.2012.6331390
Conference poster
  1. Cláudia M. Deus; Tavares, Henrique; Beatriz, Margarida; Paulo Jorge Gouveia Simoes Da Silva Oliveira; Lopes, Carla. Corresponding author: Lopes, Carla. "Impairment of mitochondrial-lysosomal axis promotes the release of pro-inflammatory cargo via extracellular vesicles". Paper presented in Innovative Therapies 4th CiBB Retreat, 2024.
  2. Tavares, Henrique; Beatriz, Margarida; Oliveira, Paulo J.; Lopes, Carla. Corresponding author: Lopes, Carla. "Decrypting Early Inflammation: The Link Between Mitochondria, Extracellular Vesicles, and Microglia". Paper presented in EMBO Workshop Microglia in Health and Disease, 2024.
  3. Cláudia M. Deus; Tavares, Henrique; Beatriz, Margarida; Paulo Jorge Gouveia Simoes Da Silva Oliveira; Lopes, Carla. Corresponding author: Lopes, Carla. "Dysregulated mitochondrial-lysosomal axis promotes the release of extracellular vesicles with pro-inflammatory potential". Paper presented in 2nd MIA-Portugal Ageing Spring School, 2024.
  4. Lopes, Carla. "Mitochondrial cargo in extracellular vesicles promotes microglia-mediated proinflammatory response". Paper presented in 3rd RESETageing Conference, 2023.
  5. Lopes, Carla. "EXOSOMES PROMOTE THE RECOVERY FROM SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE IPSC-DERIVED STRIATAL-LIKE NEURONS". Paper presented in ISSCR2021, 2021.
  6. Beatriz, Margarida; Vilaça, Rita; Rodrigues, Ricardo J.; Daley, GQ; Januário, Cristina; Schlaeger, Thorsten; Rego, Ana Cristina Carvalho (1B13-BB39-7943); Lopes, Carla. "Striatal neurons derived from Huntington's Disease patient's iPSC exhibit mitochondrial dysfunction and electrophysiological impairment". Paper presented in FENS2020, 2020.
  7. Beatriz, Margarida; Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "CRISPR/Cas9 mediated silencing of mutant huntingtin in Huntington´s disease patient-derived pluripotent and neural stem cells improves mitochondrial function". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  8. Naia, Luana; Ly, P; Mota, SI; Maranga, Carina; Lopes, Carla; Geva, Michel; Hayden, Michael; Rego, A. Cristina. "Pridopidine preserves mitochondrial morphofunction in in vitro and ex vivo Huntington's models through sigma-1 receptor-dependent decrease in oxidative stress". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases, 2019.
  9. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "Huntington's disease patient-derived induced pluripotent stem cells and neural stem cells: insights into early metabolic and mitochondrial defects". Paper presented in The International Society for Stem Cell Research (ISSCR), 2017.
  10. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "Patient-derived induced pluripotent and neural stem cells offer new insights into Huntington's Disease mechanisms". Paper presented in XV Portuguese Society for Neuroscience meeting, 2017.
  11. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Duque, C; do Carmo Macário, Maria; Fonseca, P; Vaz, M; et al. "Report of a novel mitochondrial ATP8 gene mutation in a patient with severe optic neuropathy: functional demonstration of pathogenicity". Paper presented in Sociedade Portuguesa de Doenças Metabólicas, 2017.
  12. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Diogo, Luísa; Garcia, Paula; Vaz, Mónica; Santos, Maria J.; et al. "Mitochondrial dysfunction in a lysosomal storage disorder: a case of spinocerebellar ataxia". Paper presented in MITOPORTO, 2017.
  13. Naia, Luana; Carmo, Catarina; Oliveira, A. M.; Valero, Jorge; Lopes, Carla; Oliveira, C.R.; Rosenstock, Tatiana R.; Rego, A. Cristina. "Exacerbated SIRT3 activity alters mitochondrial function and dynamics in Huntington's disease models". Paper presented in Society for Neuroscience (SfN) 2016, 2016.
  14. Simões, Marta; Bacalhau, Mafalda; do Carmo Macário, Maria; Lopes, Carla; Rego, A. Cristina; Grazina, Manuela. "Still mitochondrial dysfunction in Leber's hereditary optic neuropathy pathogenesis". Paper presented in XII SIMPÓSIO INTERNACIONAL DA SOCIEDADE PORTUGUESA DE DOENÇAS METABÓLICAS, 2016.
  15. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "nduced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances". Paper presented in 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2015.
  16. Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Rego, A. Cristina; Déglon, Nicole; Perrier, AL; Humbert, Sandrine. "Dominant-negative effects of adult onset mutant huntingtin leads to an altered division of human embryonic stem cells derived neural cells". Paper presented in ISSCR Annual Meeting, 2015.
  17. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "iPS cells derived from huntington´s disease patients exhibit mitochondrial dysfunction and metabolic disturbances". Paper presented in ISSCR Annual Meeting, 2015.
  18. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "iPSC cells derived from Huntington´s Disease patients and their differentiated counterparts exhibit mitochondrial dysfunction and metabolic disturbances". Paper presented in XIV meeting of the Portuguese Society for Neurosciences, 2015.
  19. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Santos, Maria João; Vaz, Mónica; Zuzarte, Mónica; Lopes, Carla; et al. "Functional genomics analysis to gathering evidence for m.7486G>A mutation pathogenicity". Paper presented in XIII CNC ANNUAL MEETING, 2015.
  20. Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 intranasal administration rescues Huntington’s Disease phenotypes in YAC128 mice". Paper presented in GEECD Meeting, 2014.
  21. Lopes, Carla; Aubert, Sophie; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Rego, A. Cristina. "Huntingtin regulates human neuronal stem cells division, a mechanism that is altered in Huntington's disease". Paper presented in 4th PF2MUC Symposium, 2013.
  22. Lopes, Carla; Ribeiro, Márcio; Duarte, AI; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 intranasal administration rescues Huntington's Disease phenotypes in YAC128 mice". Paper presented in FENS Forum, 2012.
  23. Lopes, Carla; Duarte, AI; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "Intranasal administration ameliorates Huntington's Disease metabolic profile and alleviates motor impairment in YAC128 mice". Paper presented in V SPB Clinical Biochemistry Workshop, Translational Molecular Biochemistry, 2012.
  24. Lopes, Carla; Duarte, AI; Oliveira, CR; Rego, A. Cristina. "IGF-1 administration in an animal model of Huntington's disease". Paper presented in SINAL, 2011.
  25. Lopes, Carla; Coelho, Cristina; Correia, Patricia; Matos, MJ. "Risk factors for Cheyne -Stokes respiration". Paper presented in 20th Congress of the European Sleep Research Society,, 2010.
  26. Lopes, Carla; Coelho, Cristina; Fradinho, Fatima; Lopes, Paulo; Matos, MJ. "Adverse effects and adherence to autoadjusting positive airway pressure". Paper presented in European Respiratory Society Congress, 2009.
Journal article
  1. Beatriz, Margarida; Ricardo Rodrigues; Rita Pereira Vilaça (B317-85CF-B04B); Conceição Egas; Paulo César Silva Pinheiro; Daley, George Q.; Schlaeger, Thorsten M.; et al. Corresponding author: Lopes, Carla. "Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC derived neurons". Theranostics 13 11 (2023): 3707-3724.
    Published
  2. Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla. Corresponding author: Lopes, Carla. "Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease". Journal of Extracellular Biology 1 10 (2022): e65. http://dx.doi.org/10.1002/jex2.65.
    Published • 10.1002/jex2.65
  3. Deus, Cláudia M.; Tavares, Henrique; Beatriz, Margarida; Mota, Sandra; Lopes, Carla. Corresponding author: Lopes, Carla. "Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders". Cells 11 15 (2022): 2364. http://dx.doi.org/10.3390/cells11152364.
    Open access • 10.3390/cells11152364
  4. Lopes, Carla; Ferreira, I. Luísa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, José; Castelhano, João; et al. "Mitochondrial and redox modifications in early stages of Huntington's disease". Redox Biology (2022): 102424. http://dx.doi.org/10.1016/j.redox.2022.102424.
    10.1016/j.redox.2022.102424
  5. Beatriz, Margarida; Vilaça, Rita; Ana Cristina Carvalho Rego; Lopes, Carla. Corresponding author: Lopes, Carla. "Defective mitophagic clearance of damaged mitochondria promotes extracellular vesicle-mediated release of mitochondrial components in huntington's disease". European Journal of Clinical Investigation 52 S1 (2022): http://dx.doi.org/10.1111/eci.13796.
    Published • 10.1111/eci.13796
  6. Beatriz, Margarida; Lopes, Carla; Ribeiro, Ana Cláudia S.; Rego, Ana Cristina Carvalho. "Revisiting cell and gene therapies in Huntington's disease". Journal of Neuroscience Research 99 7 (2021): 1744-1762. http://dx.doi.org/10.1002/jnr.24845.
    10.1002/jnr.24845
  7. Beatriz, Margarida; Vilaça, Rita; Lopes, Carla. Corresponding author: Lopes, Carla. "Exosomes: Innocent bystanders or critical culprits in neurodegenerative diseases". Frontiers in Cell and Developmental Biology (2021): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155522/.
    Open access • Published
  8. Naia, Luana; Ly, Philip; Mota, Sandra I.; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al. "The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models". Neurotherapeutics (2021): http://dx.doi.org/10.1007/s13311-021-01022-9.
    Published • 10.1007/s13311-021-01022-9
  9. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al. "Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics". Free Radical Biology and Medicine 163 (2021): 163-179. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031.
    Open access • Published • 10.1016/j.freeradbiomed.2020.11.031
  10. Lopes, Carla; Tang, Yang; Anjo, Sandra I.; Manadas, Bruno; Onofre, Isabel; de Almeida, Luís P.; Daley, George Q.; Schlaeger, Thorsten M.; Rego, Ana Cristina Carvalho. "Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting". Frontiers in Cell and Developmental Biology 8 (2020): 967. http://dx.doi.org/10.3389/fcell.2020.576592.
    Open access • Published • 10.3389/fcell.2020.576592
  11. Beatriz, Margarida; Rita Pereira Vilaça (B317-85CF-B04B); Thorsten Michael Schlaeger; Daley, George Q.; Ana Cristina Carvalho Rego; Lopes, Carla. "Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics". European Journal of Clinical Investigation 50 S1 (2020): http://dx.doi.org/10.1111/eci.13369.
    10.1111/eci.13369
  12. Lopes, Carla; Castelhano, Joao; Margarida Fernandes Beatriz (431D-E8EB-DA99); Carolina Fernandes; Mário Laço; Cristina Januário; Abrunhosa, Antero J; Castelo-Branco, Miguel; Ana Cristina Carvalho Rego. "Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers". European Journal of Clinical Investigation 50 S1 (2020): http://dx.doi.org/10.1111/eci.13369.
  13. Lopes, Carla; Schlaeger, Thorsten; Pereira de Almeida, Luis ; Daley, George Q.; Ana Cristina Carvalho Rego. "Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington´s Disease patient-derived pluripotent and neural stem cells". European Journal of Clinical Investigation 49 S1 (2019): 53-100. http://dx.doi.org/10.1111/eci.13108.
    10.1111/eci.13108
  14. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Lopes, Carla; Valero, Jorge; Rosenstock, Tatiana R.; Giorgini, Flaviano; Cristina Rego, A.. "SIRT 3 , a modifier of mitochondrial function in Huntington's disease". Free Radical Biology and Medicine 120 (2018): S17. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.072.
    Open access • Published
  15. Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al. "Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant". Neuromuscular Disorders 28 4 (2018): 350-360. http://dx.doi.org/10.1016/j.nmd.2017.11.006.
    Open access • Published • 10.1016/j.nmd.2017.11.006
  16. Naia, Luana; Ribeiro, Márcio; Rodrigues, Joana; Duarte, Ana I.; Lopes, Carla; Rosenstock, Tatiana R.; Hayden, Michael R.; Rego, A. Cristina. "Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin". Neuropeptides 58 (2016): 73-81. http://dx.doi.org/10.1016/j.npep.2016.01.009.
    Published • 10.1016/j.npep.2016.01.009
  17. Lopes, Carla; Rego, A. Cristina. "Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?". Molecular Neurobiology 54 3 (2016): 1858-1873. http://dx.doi.org/10.1007/s12035-016-9714-8.
    Open access • Published • 10.1007/s12035-016-9714-8
  18. Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Barnat, Monia; Rego, Ana Cristina; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Blum, David. "Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells". PLOS ONE 11 2 (2016): e0148680-e0148680. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148680.
    Open access • Published • 10.1371/journal.pone.0148680
  19. Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice". Molecular Neurobiology 49 3 (2013): 1126-1142.
    Published • 10.1007/s12035-013-8585-5
  20. Lopes, Carla Maria Nunes; Duarte, Ana I.; Hayden, Michael; Ana Cristina Carvalho Rego. "Peripheral and cerebral metabolic features in an animal model of Huntington's disease". IEEE Xplore Digital Library , (2012): 1-5. http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6331390&isnumber=6331337.
    Published • 10.1109/enbeng.2012.6331390
Newspaper article
  1. Lopes, Carla. "Viagens no cérebro em BD", Publico, 2017, https://www.publico.pt/2017/03/24/ciencia/fotogaleria/viagens-no-cerebro-em-bd-371640.
Thesis / Dissertation
  1. Lopes, Carla Maria Nunes. "Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease". PhD, 2015. http://hdl.handle.net/10316/28370.
  2. Lopes, Carla Maria Nunes. "Peripheral and cerebral metabolic features in an animal model of Huntington's Disease expressing full-length mutant huntingtin". Master, 2010. http://hdl.handle.net/10316/13790.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/31 Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons EVclub - https://www.youtube.com/@ExtracellularVesicleClub
International Society for Extracellular Vesicles
2024/10/17 Mitochondrial DAMPs in EVs: Triggering Early Neuroinflammation in Neurodegeneration The First Conference on Targeting Extracellular Vesicles
World Mitochondria Society
2024/05/27 Mitochondrial components in Parkinson's Disease extracellular vesicles activate pro-inflammatory response in microglia 2nd MIA-Portugal Ageing Spring School
MIA (Portugal)
2024/04/24 Invited speaker at DCV talks. Decrypting Early Inflammation: The Link Between Mitochondria, Extracellular Vesicles, and Microglia DCV.talks
DCV-UC (Coimbra, Portugal)
2023/10/11 Mitochondrial Cargo in Extracellular Vesicles Promotes Microglia-Mediated Proinflammatory Response Targeting Mitochondria World Congress 2023
World Mitochondria Society (Berlin, Germany)
2023/05/13 Mitochondria damage-associated molecular patterns associated to extracellular microvesicles promote microglia-mediated proinflammatory response MITOPORTO
University of Porto - FFUP (Porto, Portugal)
2022/06/09 Defective mitophagic clearance of damage mitochondria promotes extracellular vesicle-mediated release of mitochondrial components in Huntington's Disease ESCI 2022
European Society for Clinical Investigation (Bari, Italy)
2021/10/05 Exosomes promote the recovery from synaptic dysfunction in human Huntington's disease iPSC-derived striatal-like neurons The Synaptic Dimension of Brain Disorders
Universidad Internacional de Andalucía (Baeza, Spain)
2021/06/10 FIBROBLASTS-DERIVED EXTRACELLULAR VESICLES REVERT SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE STRIATAL NEURONS ESCI 2021 Annual Scientific Meeting
European Society for Clinical Investigation
2021/06/10 Extracellular vesicles from fibroblasts of Huntington's Disease patients are involved in the transfer of mitochondrial components ESCI 2021 Annual Scientific Meeting
European Society for Clinical Investigation
2021/05/18 Extracellular vesicles cargo as biomarker of mitochondrial dysfunction in Huntington's Disease ISEV2021
ISEV
2021/01/20 Exosomes in Huntington's Disease: Innocent bystanders or major culprits? NEUROSCIENCE AND DISEASE THEMATIC LINE
Coimbra Institute for Clinical and Biomedical Research (Portugal)
2020/09/24 Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics ESCI Virtual Meeting 2020 | Covid19 edition
European Society for Clinical Investigation
2020/09/22 Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers ESCI Virtual Meeting 2020 | Covid19 edition
European Society for Clinical Investigation
2020/07 Doença de Huntington: como é que as células estaminais podem ajudar? Zooming on Science
Center for Neuroscience and Cell Biology (Portugal)
2019/05/23 Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington's disease patient-derived pluripotent and neural stem cells 53rd Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/03/15 CRISPR/Cas9 mediated silencing of mutant huntingtin in Huntington´s disease patient-derived pluripotent and neural stem cells improves mitochondrial function Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Curia, Portugal)
2019/03/15 Radiolabeled Cu-ATS as a novel biomarker for oxidative stress based on mitochondrial dysfunction in huntington’s disease Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Curia, Portugal)
2018/05 SIRT3, a modifier of mitochondrial function in Huntington's disease 19th biennial meeting for the Society for Free Radical Research International (SFRRI)
Lisbon Conference Centre (Lisboa, Portugal)
2017/03/16 Report of a novel mitochondrial ATP8 gene mutation in a patient with severe optic neuropathy: functional demonstration of pathogenicity 13º Simpósio Internacional da Sociedade Portuguesa De Doenças Metabólicas
Sociedade Portuguesa De Doenças Metabólicas (Évora, Portugal)
2017 Mitochondrial defects in Huntington's disease: what can we learn from patient-derived induced pluripotent and neural stem cell models? Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Ofir, Portugal)
2017 Mitochondrial defects in Huntington’s disease patient-derived induced pluripotent stem cells and differentiated counterpart SPF 2017 - XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa De Farmacologia (Coimbra, Portugal)
2016/11/18 Induced pluripotent and neural stem cells derived from Huntington´s disease patient exhibit mitochondrial and metabolic abnormalities BRAIN WITHOUT BORDERS - modelling, disease and repair
Portuguese Society for Stem Cells and Cell Therapies (Coimbra, Portugal)
2016 Evaluation of m.7486G>A pathogenicity using a functional genomics 12º International Symposium
Sociedade Portuguesa de Doenças Metabólicas (Coimbra, Portugal)
2016 Still mitochondrial dysfunction in Leber's Hereditary Optic Neuropathy pathogenesis XII Simpósio Internacional da Sociedade Portuguesa De Doenças Metabólicas
Sociedade Portuguesa De Doenças Metabólicas (Coimbra, Portugal)
2015/10/15 Induced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Oeiras, Portugal)
2015 Functional genomics analysis to gathering evidences for m.8476G>A mutation pathogenicity XIII Annual Meeting from center for neuroscience and cell biology
center for neuroscience and cell biology (coimbra, Portugal)
2015 Induced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances 9º Encontro Internacional da SPCE-CT
SPCE-CT (Oeiras)
2015 Functional genomics analysis to gathering evidence for m.7486G>A mutation pathogenicity XIII CNC Annual Meeting
Centro de Neurociências de Coimbra (Coimbra, Portugal)
2013 IGF-1 intranasal administration rescues Huntington’s Disease phenotypes in YAC128 mice CNC Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2012 Peripheral and cerebral metabolic features in an animal model of Huntington’s disease 2nd Portuguese BioEngineering Meeting
IEEE (Coimbra)
2010 Peripheral and cerebral metabolic features in an animal model of Huntington’s disease expressing full-length mutant huntingtin 4ª Reunião do GEECD
GEECD (Tomar)
2009 Obstructive sleep apnea syndrome and nonarteritic anterior ischemic optic neuropathy ERS Annual Congress
European Respiratory Society (Viena)
2009 Anterior ischemic optic neuropathy and sleep apnea syndrome LII Portuguese Congress of Ophthalmology
Portuguese Society of Ophthalmology (Vilamoura, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/30 - Current Micronuclei and extracellular vesicles
Supervisor
 Pharmaceutical Technology (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/09/01 - 2022/09/30 Role of Mitochondria-Derived Damage-Associated Molecular Patterns associated with extracellular microvesicles in promoting early microglia-mediated pro-inflammatory response in neurodegenerative disorders
Supervisor
 Engenharia Biomédica (Master)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/01 - 2022/06 iPSC-derived Human Microglia to study early neuroinflammatory response in amyotrophic lateral sclerosis (ALS)
Supervisor
 Engenharia Biomédica (Degree)
Universidade de Coimbra Departamento de Física, Portugal
2020 - 2022 MSc Research fellow on the FCT project (POCI-01-0145-FEDER-029621 )
Supervisor
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2021 - 2021 Supervisor of the Post-Doctoral Researcher hired for the project funded by POCI-01-0145-FEDER-029621
Supervisor of Claudia Deus
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2018 - 2020 Supervisor of the Post-Doctoral Researcher hired for the project funded by POCI-01-0145-FEDER-029621
Supervisor
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019 - 2019 Mitochondrial characterization in Huntington´s Disease fibroblasts and iPSC-derived cells
Supervisor
 Engenharia Biomédica (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09 - 2017/07 Transcriptional and redox changes in Huntington's disease human stem cells
Co-supervisor
 Master in Molecular and Cell Biology (Master)
Universidade de Aveiro, Portugal
2016 - 2016 Exploring alterations in metabolism and mitochondrial dynamics in stem cell models of Huntington's Disease
Supervisor
 Neurasmus (Master)
Centro de Neurociencias e Biologia Celular, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/11/28 - Current Organizer of an activity for the Semana da Ciência e Tecnologia 2024 at St. Paul's School (English spoken) for 20 high school students. The activity lasted 3 hours and included a theoretical introduction and a hands-on activity about "The genetics of ageing". (2024/11/28)
Workshop (Co-organisor)
 Multidisciplinary Institute of Aging, Portugal
2024/10/17 - Current Moderator of the Short Oral Presentations session at the First World Conference Targeting Extracellular Vesicles (2024/10/17)
Conference (Member of the Organising Committee)
 World Mitochondria Society, Germany
2024/09/27 - Current Organization of an activity at the European Researchers' Night "BIOSINAIS- JANELAS PARA O NOSSO CORPO!" at the downtown of Coimbra (2024/09)
Festival (Co-organisor)
 University of Coimbra- Multidisciplinary Institute of Ageing, Portugal
2024/02/07 - Current Coordinator of an activity at the sixth edition of UC Science Week "The genetic of ageing" funded by PRR with €500. https://www.uc.pt/site/assets/files/1220679/cartaz-6_edicao_semana_da_ciencia_uc.png (2024/02/07)
Workshop
 Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/09/29 - Current Coordinator of an activity at the European Researchers' Night "Bringing the Matrix to Life! The body-computer interfaces" at the downtown of Coimbra, interacting directly with the population and the citizens of Coimbra. (2023/09/29)
Festival
 Universidade de Coimbra, Portugal
2022/09/30 - Current Coordinator of an activity at the European Researchers' Night "Bringing the Matrix to Life! The body-computer interfaces" at the downtown of Coimbra, interacting directly with the population and the citizens of Coimbra. (2022/09/30)
Festival (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/12/06 - 2024/12/06 Chair of a seminar at “The MIA-Portugal Ageing Seminars“ hosting Dr Ioannis Sotiropoulos (2024)
Seminar (Member of the Scientific Committee)
 University of Coimbra- Multidisciplinary Institute of Ageing, Portugal
2024/10/17 - 2024/10/18 Panel Moderator at the First Conference on Targeting Extracellular Vesicles (2024)
Congress (Member of the Organising Committee)
2024/06/24 - 2024/06/28 Organization of a one-week summer internship as part of the “Ciência Viva no Laboratório” programme, promoted by Ciência Viva - National Agency for Scientific and Technological Culture. (2024/06/24 - 2024/06/28)
Workshop (Co-organisor)
 Universidade de Coimbra, Portugal
2024/05/09 - 2024/05/09 Coordinator of activity at the eighth edition of UC Science Week "The genetic of ageing" funded by PRR with €500. (2024/05)
Workshop (Member of the Organising Committee)
 Universidade de Coimbra, Portugal
2024/04/07 - 2024/04/07 Workshop organization on stem cells. Meet.Lab Coimbra is an event organised by the Biology Students' Group of the Coimbra Academic Association, with a strong laboratory component. https://www.instagram.com/_meet.lab_/. (2024/04/07)
Workshop (Co-organisor)
 Universidade de Coimbra, Portugal
2022/07/01 - 2022/08/12 Coordinator of a summer internship in the laboratory for two Biomedical Engineering students in collaboration with ANEEB - Associação Nacional de Estudantes de Engenharia Biomédica. (2022 - 2022)
Other
 Centro de Neurociencias e Biologia Celular, Portugal
2022/06/27 - 2022/07/01 Organization of a summer internship in the laboratory for two high school students in collaboration with the "Ciência Viva no Laboratório -Ocupação Científica de Jovens nas Férias". The internship aimed to encourage the students to explore the "stem cell world" https://www.cienciaviva.pt/ciencia-viva-no-laboratorio/estagios/2022/ 1775. À DESCOBERTA DAS CÉLULAS ESTAMINAIS. (2022/06/27 - 2022/07/01)
Other (Co-organisor)
 Ciência Viva, Portugal
2020/08 - 2020/10 “Curso de Verão da UC "Metodologias de Investigação Científica" - Módulo de I&D "Metodologias Avançadas para o Estudo do Cérebro" (2020/08 - 2020/10)
Workshop (Co-organisor)
 Universidade de Coimbra, Portugal
2016/05 - 2016/05 Synaptosomes as a model of presynaptic dysfunction in brain pathologies - the role of mitochondria Workshop for Biology students (2016/05 - 2016/05)
Workshop (Co-organisor)
 XIX Encontro Nacional de Estudantes de Biologia, Portugal
2012/12/19 - 2012/12/20 Participation on the organizing committee of the X Center for Neuroscience and Cell Biology Annual Meeting (2012/12/19 - 2012/12/20)
Congress (Co-organisor)
 Centro de Neurociencias e Biologia Celular, Portugal
2012 - 2012 Session about Drug Abuse and Addiction in High School included in the program "Ciência Viva"¿ (2012 - 2012)
Seminar (Other)
 Centro de Neurociencias e Biologia Celular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/31 - Current Invited speaker at the Pint of Science Festival. The festival aims to deliver exciting and relevant talks on the latest scientific research in an accessible format to the public mainly across bars, pubs, cafes, and other public spaces. I participate as a speaker talking about stem cells "Células estaminais ao poder!". https://www.pintofscience.pt/coimbra-31-cabecinhapensadora
Festival
 PINT OF SCIENCE PORTUGAL
Pint of Science , United Kingdom
2022/12/14 - Current Participation at the UC Science Week at "Escola Secundária Afonso Lopes Vieira", Leiria with hands-on activities. https://www.uc.pt/fctuc/dcv/outros-cursos/formacao-em-literacia-cientifica-semana-da-ciencia-uc/2-edicao/
Workshop
 UC Science Week
Universidade de Coimbra, Portugal
2022/05/19 - Current Participation at the UC Science Week 2022 at "Escola Secundária Adolfo Portela, em Águeda." https://www.uc.pt/fctuc/dcv/outros-cursos/formacao-em-literacia-cientifica-semana-da-ciencia-uc/1-edicao/#7
Workshop
 Semana da Ciência UC 2022
Universidade de Coimbra, Portugal
2022/03/25 - Current Brain Awareness Week - Lecture and hand-on activities in middle school "Infanta D. Maria" in Coimbra.
Seminar
 Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2021/10/13 - Current Stem Cell Awareness Day 2021 - Lectures in two middle schools for approximately 100 students.
Seminar
 Stem Cell Awareness Day 2021
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/05/24 - Current Panel Moderator at the 3rd CIBB Neuroscience and Disease retreat
Meeting
 3rd CIBB Neuroscience and Disease retreat
2019/11/26 - Current Science and Technology Week. The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community.
Workshop
 Science and Technology Week 2019
Centro de Neurociencias e Biologia Celular, Portugal
2014 - Current Participation at Brain Awareness Week (BAW) with a session "Neuroscientists go to school" at an Elementary School
Seminar
 Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2022/03/03 - 2022/03/03 Webinar - NRF2 and Cancer “Bench to Bedside transition for Pharmacological regulation of NRF2 in non communicable diseases”
Seminar
 Organized in cooperation with the COST action CA20121
Universidad Autónoma de Madrid, Spain

Faculty of Pharmacy and Medicine, Sapienza University of Rome, Italy
2021/10/28 - 2021/10/29 EMBO WORKSHOP "Microglia 2021" - This workshop highlighted the many important functions of microglia to nervous system physiology and function, the newest and most exciting literature and brought together researchers using state-of-the-art imaging, genomics and molecular biology to study these enigmatic cells.
Workshop
 Microglia 2021
European Molecular Biology Laboratory, France
2021/10/04 - 2021/10/06 "THE SYNAPTIC DIMENSION OF BRAIN DISORDERS" - The synapse is the fundamental information-processing unit of the brain, and has recently been shown to lie at the root of a wide range of brain disorders. The purpose of this workshop is to present the most relevant and recent advances in the study of synaptic dysfunction in the context of brain disorders. In this workshop we aim to bring together leading scientists in the growing field of synaptopathies, to hear about their latest discoveries.
Workshop
 THE SYNAPTIC DIMENSION OF BRAIN DISORDERS
Universidad Internacional de Andalucía, Spain
2021/03/22 - 2021/03/26 During Brain Awareness Week (BAW), a global campaign to increase public awareness of the progress and benefits of brain research, several events are organized by CNC. I gave a lecture on brain-related subjects to 100 high school students from Escola Secundária da Mealhada.
Conference
 Brain Awareness Week
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/04/01 - 2020/05/01 Volunteer as part of COVID-19 UC Lab
Other
Universidade de Coimbra, Portugal
2017 - 2019 Brain Awareness Week Several actions take place for school-age children and the general public. During the action "Neuroscientists go to Schools" neuroscientists visit schools from the region and give lectures on brain-related subjects to high school students; elementary and middle school students perform hands-on activities also on brain-related subjects. During the action "Open Laboratories" students visit CNC laboratories and take part in talks about neuroscience research.
Workshop
 Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2018/11/19 - 2018/11/23 Science and Technology Week 2018 The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community
Other
 Science and Technology Week 2018
Centro de Neurociencias e Biologia Celular, Portugal
2018 - 2018 Participation with microscopy cell images on the science photography exhibition "The Beauty in our Cells" organized by Exploratório /Centro Ciência Viva Coimbra in collaboration with Center for Neuroscience and Cell Biology, Coimbra.
Exhibition
 Projects in collaboration with the Science Center Exploratório Infante D. Henrique
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2017 Science and Technology Week 2017 The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community.
Other
 Science and Technology Week 2017
Centro de Neurociencias e Biologia Celular, Portugal
2017 - 2017 Collaboration in the writing of a comic about neuroscience published at Journal Público during the Brain Awareness Week
Other
 Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2017 - 2017 Collaboration at European Researchers' Night at hands-on experiments, more specific activities involving the ulnar nerve stimulation and related muscle activation for the general population.
Exhibition
 European Researchers' Night 2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/09/16 Reprogramação de astrócitos em neurónios para tratar a Ataxia Espinocerebelar Tipo 3 Estudos de prova de conceito
(Thesis) Main arguer
 Vanessa Silva Santos (Master)
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/10/13 Associated Molecular Patterns associated to extracellular microvesicles in promoting early microglia-mediated pro-inflammatory response in neurodegenerative disorders
(Thesis) Arguer
 Henrique Rafael Freitas Tavares (Master)
Universidade de Coimbra, Portugal
2022/07/14 Relação do silenciamento das proteínas TRAP1 e da p66Shc no contexto do cancro do pulmão e sobrevivência celular ao meio Iscove.
(Thesis) Main arguer
 Juliana Maria Pereira Azevedo (Other)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019 Patient-specific iPSC-derived NESC for Machado-Joseph Disease treatment
(Thesis) Main arguer
 Vanessa Alexandra Castanheira Fernandes (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/10/01 - Current Journal of Alzheimer’s Disease (1875-8908) SAGE
2024/06 - Current Theranostics (1838-7640)
2024/05 - Current FEBS Letters (1873-3468)
2023/08 - Current Science Advances (2375-2548) American Association for the Advancement of Science
2023/06/17 - Current Communications Biology ( 2399-3642) Springer Nature
2022/10 - Current Cells (2073-4409) MDPI
2022/07/06 - Current Pharmaceuticals (1424-8247) MDPI
2022/03/15 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2022/01/29 - Current Scientific Reports (2045-2322 ) Springer Nature
2021/06 - Current Journal of Integrative Neuroscience (1757-448X) IMR PRESS

Association member

Society Organization name Role
2024/11/20 - Current Associate Editor for the Journal of Extracellular Biology Associate Editor
2023/11/01 - Current Portuguese Network on Extracellular Vesicles (PNEV) Member
2023/09/01 - Current International Society for Extracellular Vesicles Senior member
2023/09/01 - Current ISEV Special Interest Groups "Extracellular Vesicles in the Nervous System" Member
2019/05 - Current The European Society for Clinical Investigation Member
2017/12/14 - Current European Huntington's Disease Network Member
2015/03/05 - Current Portuguese Society for Neuroscience Member
2015/02 - 2022/02 International Society for Stem Cell Research Member

Committee member

Activity description
Role 		Institution / Organization
2021/01/03 - Current Member of the MIA Scientific Council
Member
 University of Coimbra- Multidisciplinary Institute of Ageing, Portugal

Conference scientific committee

Conference name Conference host
2024/09/26 - 2024/09/27 First Conference on Targeting Extracellular Vesicles World Mitochondria Society

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09/01 - Current Cellular Physiology from the Bachelor's Degree in Biology, 2nd year, 1st Semester Cellular Phisiology (Licenciatura) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2024/03/06 - Current Lecturer of the class "Cancer-associated neurons" at the Master in Cellular and Molecular Biology in the unit "Molecular Biology of Cancer" (Mestrado) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/03/14 - Current Lecturer/ Practical classes at the Master in Cellular and Molecular Biology at the unit "Molecular Biology of Cancer" Master in Cellular and Molecular Biology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra, Portugal
2022/03/09 - Current Lecture on the topic "Mitochondrial-derived Vesicles as Cellular Stress Responses" integrated into the course "ONE HEALTH and the Metabolism-Disease-Environment Triangle: When Biomedicine meets Innovation, Science Outreach and Social Sciences" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNC, University of Coimbra, Coimbra, Portugal. PDBEB Courses 2021/2022 (Doutoramento) Centro de Neurociencias e Biologia Celular, Portugal
2023/03/15 - 2023/03/15 Lecturer of the class "Cancer-associated neurons" at the Master in Cellular and Molecular Biology in the unit "Molecular Biology of Cancer" Master (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/02 - 2019/07 Investigação Aplicada II Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03 - 2018/07 Pathology II Fisiologia Clínica (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2017/09 - 2018/02 Pathology I Fisiologia Clínica (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2016 - 2016 Can iPSC help to decipher the metabolic alterations found in HD? Extensão e divulgação científica (Curso médio) Neurobiologia II, MESTRADO INTEGRADO EM ENGENHARIA BIOMÉDICA, Portugal
2007/02 - 2011/07 Lecturer of Sleep Pathology Fisiologia Clínica (Licenciatura) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/04 - Current Member of the pool of reviewers of ANR (French Research Funding Agency)
Evaluator
 French Research Funding Agency, France French Research Funding Agency

Journal scientific committee

Journal title (ISSN) Publisher
2021/12/10 - Current Frontiers in Aging Neuroscience (16634365) Frontiers Media S.A.
2021/12/10 - Current Cells (2073-4409) MDPI
2021/11/06 - Current Communicative & Integrative Biology (1942-0889) Taylor & Francis
2021/09 - Current BBA Advances (2667-1603) Elsevier
2021/09 - Current Cells (2073-4409) MDPI
2021/08 - Current JoVE ( 1940-087X) Jove Books
2021/07/30 - Current Brain Sciences (2076-3425) MDPI
2021/06 - Current Biomedicines MDPI
2021/06 - Current BIOCELL (1667-5746) Tech Science Press
2021/05 - Current European Journal of Clinical Investigation (1365-2362) Wiley Online Library
2016/03/01 - 2016/04/30 Gene Expression Patterns elsevier

Mentoring / Tutoring

Topic Student name
2024/05 - 2024/05 LABORATORY ROTATIONS from Master in Biomedical Research Rita Menino
2024/01/29 - 2024/02/23 LABORATORY ROTATIONS in Master's degree in Cellular and Molecular Biology Guilherme Rolo
2023/12/04 - 2023/12/22 LABORATORY ROTATIONS in DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE Archana Raghunathan
2023/12/11 - 2023/12/15 LABORATORY ROTATIONS in DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE Filipa Gaspar do Espírito Santo Martins da Silva
2020/08 - 2020/10 Verão Com Ciência, atribuído pela Fundação para a Ciência e a Tecnologia. Maria Brigída
2018/09 - 2019/06 Supervision of a secondary school student Hugo Coimbra
2019/01/28 - 2019/02/28 Master's degree in Cellular and Molecular Biology Catarina Vinhas
2018/10 - 2019/01 International student exchange Bruno Macedo Pinto
2018/09/03 - 2018/09/07 Ciência Viva at the Laboratory Hugo Coimbra; Inês Ferreira
2018/05/07 - 2018/06/01 Master's degree in Cellular and Molecular Biology Marlene Domingues
2016/02 - 2016/07 Neurasmus Sahana Srinivasan
2016/05 - 2016/05 Master in Molecular and Cell Biology Nuno Piedade
2016/02/03 - 2016/03/02 Program Research Exchange José Vitor Magalhães Cardoso

Other jury / evaluation

Activity description Institution / Organization
2024/05/20 - Current A jury in the international call for a doctoral post with the reference number IT057-24-13900. Universidade de Coimbra, Portugal
2021/08/12 - Current Jury in the international call for a Laboratory Technician (Master degree) post with the reference CTM - 29621. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/06 - 2023/06 Jury member Universidade de Coimbra, Portugal
2021/09 - 2021/10 Jury in the international call for a doctoral post with the reference number 29621.08.2021 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02 - 2021/02 Jury in the international call for a doctoral post with the reference number INV JR 2020. nº 029621. Centro de Neurociencias e Biologia Celular, Portugal
2019/08 - 2019/08 Jury in the international call for a doctoral post with the reference number INV JR 2019. 49 nº 029621. Centro de Neurociencias e Biologia Celular, Portugal
2018/07 - 2018/07 Jury in the call for a Master Research Fellowship with the reference “BIM/ACREGO”. Centro de Neurociencias e Biologia Celular, Portugal
Distinctions

Award

2024 EMBO Microglia 2024 Travel Award
European Molecular Biology Laboratory, Germany
2022 2022 ESCI Bio Art Award
European Society for Clinical Investigation, Netherlands
2021 Poster Prize at ESCI's 55TH Virtual ASM
European Society for Clinical Investigation, Netherlands
2021 Funding EMBO Workshop
European Molecular Biology Laboratory, France
2020 Best Short Presentation at ESCI 2020 Virtual Meeting
European Society for Clinical Investigation, Netherlands
2019 Best oral communication of basic science at SPDM
Sociedade portuguesa de Doenças do Movimento, Portugal
2019 ESCI Bio Art Award
The European Society for Clinical Investigation , Netherlands
2017 ISSCR Travel Award
International Society for Stem Cell Research, United States
2015 Best poster selected for oral presentation
Portuguese Society for Stem Cells and Cell Therapies, Portugal
2014 Best scientific photo
Centro de Neurociencias e Biologia Celular, Portugal
2012 Best master thesis
2nd Portuguese BioEngineering Meeting, Portugal

Other distinction

2015 Team member of the winning project submitted to FLAD LIFE SCIENCE 2020
Fundação Luso-Americana, Portugal