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Carolina Ferreira is currently a PhD student enrolled at the Health Sciences Program from the Faculty of Medicine of the University of Coimbra, in the Institute of Pharmacology and Experimental Therapeutics , after being awarded a FCT PhD grant (2021.05312.BD) with the project "Blueberry leaf biomass: a nutraceutical for Multiple Sclerosis’ relief by targeting the gut-immune-CNS axis", under the supervision of Flávio Reis, Sofia Viana and Miguel Castelo-Branco. Previously, in the same Faculty she concluded a Master's degree in Biomedical Research, in the branch of Neurosciences, preceded by a Bachelor's degree in Biochemistry from the University of Coimbra. Her master thesis entitled "Preclinical evaluation of the therapeutic potential of Vaccinium corymbosum L. (blueberry) leaf biomass in experimental Multiple Sclerosis" was developed at the Coimbra Institute for Clinical and Biomedical Research (iCBR) - Faculty of Medicine from Coimbra University (FMUC). Both degrees have provided her with solid knowledge in animal experimentation, molecular and biological sciences supported by the practice of distinct techniques such as PCR, Western Blot, and microscopy, among others. Being part of the research group "Insulin Resistance and Diabetic Angiopathy", coordinated by Flávio Reis, she developed research work related to therapeutic and nutraceutical approaches in the prevention and/or treatment of neurodegenerative disorders, using animal models of cuprizone-induced demyelination. She has been involved in several preclinical research projects, such as "FRUTIFY: Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes" [PTDC/SAU-NUT/31712/2017], funded by the Foundation for Science and Technology (FCT), and "Remielinization promoting strategies for an animal model of Multiple Sclerosis" [INOVC2020-SAAC-CENTRO-46-2016-01-5625], funded by INOVC 2020. During her research carrier, she had the opportunity to author three review-papers published in international peer-reviewed journals. Furthermore, Carolina has been an active communicator of her research outputs by participating in several national meetings resulting in 4 oral communications as first author. Alongside her research activity, Carolina actively contributed to the laboratory training of undergraduate and graduate students. Likewise,she participates in a project under a confidentiality agreement, related with the development of a "Semi-solidformulation for voluntary oral administration of bioactive compounds in rodents", which is currently under an International Patent Application (no PCT/IB2021/053124). In 2020, she attained Functions A+B for manipulation and design of animal experimental protocols, certified by DGAV, the National Authority for Regulation of Animal Research. Carolina was also involved in an awarded distinction with the 1st Place in the Sustainable Campus Network competition - "From linear to circular ideas".
Identification

Personal identification

Full name
Ana Carolina Marques Ferreira

Citation names

  • Ferreira, Carolina

Author identifiers

Ciência ID
0E14-4554-7C81
ORCID iD
0000-0002-4074-9513

Email addresses

  • f202carolina@gmail.com (Professional)

Addresses

  • iCBR / FMUC, Polo III - Health Sciences Campus - Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Celas, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Proficiency (C2) Upper intermediate (B2) Proficiency (C2) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2023/05/29 - 2023/06/09
Concluded
Advanced Imaging Methods in Neuroscience (Curso médio)
Major in Imagiologia em Neurociência
Universidade de Coimbra, Portugal

Universidad de Salamanca, Spain
2023/04/27 - 2023/06/02
Concluded
Online Advanced Course on Biomedical Imaging 2023 (Curso médio)
Major in Imagiologia Biomédica
Universidade de Coimbra, Portugal

The University of Texas at Austin UT Health Austin, United States
2023/03/07 - 2023/03/08
Concluded
Flow Cytometry and Cell Sorting - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Curso médio)
Major in Flow Cytometry
Universidade de Coimbra, Portugal
2023/01/23 - 2023/01/27
Concluded
Business Ignition Program in Ageing (Curso médio)
Universidade de Coimbra, Portugal

Instituto Pedro Nunes, Portugal
2022/07/05 - 2022/07/07
Concluded
Competency Based Skills Training in Mice and Rats (Curso médio)
CNC.IBILI, Portugal
2022/03/11 - 2022/06/03
Concluded
Online Advanced Course on Biomedical Imaging 2022 (Curso médio)
Major in Imagiologia Biomédica
The University of Texas at Austin UT Health Austin, United States
2020/09/16 - 2021/10/05
Concluded
Masters in Biomedical Research (Mestrado)
Major in Neurosciences
Universidade de Coimbra Faculdade de Medicina, Portugal
"Preclinical evaluation of the therapeutic potential of Vaccinium corymbosum L.(blueberry) leaf biomass in experimental Multiple Sclerosis" (THESIS/DISSERTATION)
18
2020/11/09 - 2020/11/20
Concluded
IV Modular Training in Laboratory Animal Course - Function B (Curso médio)
Major in Designing procedures and projects
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
17
2020/11/09 - 2020/11/20
Concluded
IV Modular Training in Laboratory Animal Course - Function A (Curso médio)
Major in Carrying out procedures on animals
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
17,75
2020/03 - 2020/03
Concluded
Fluorescence and Confocal Microscopy training (Curso médio)
CNC.IBILI, Portugal
2016/09/18 - 2019/07/20
Concluded
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The role of anthocyanins from portuguese blueberries in Autism Spectrum Disorder" (THESIS/DISSERTATION)
16,4
Projects

Contract

Designation Funders
2020/06 - Current NephroCardio Risk - Reliable biomarkers of chronic kidney disease and of the associated cardiovascular risk. Construction of (bio)sensors for the selected biomarkers
Norte-01-0145-FEDER-000024
Animal care
Universidade do Porto Faculdade de Farmácia, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal
European Regional Development Fund
Ongoing
2020 - Current FRUITIFY - Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017
POCI-01-0145-FEDER-031712
PTDC/SAU-NUT/31712/2017
Animal care
CNC.IBILI, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - Current INOVC2020 - IGNITION GRANT - The therapeutic potential of Vaccinium corymbosum L. senescent leaves (blueberries) in Multiple Sclerosis: adding value to a regional agro-waste product.
INOVC2020-SAAC-CENTRO-46-2016-01-5625
Colaboradora
Universidade de Coimbra Faculdade de Medicina, Portugal
European Regional Development Fund
Ongoing
Outputs

Publications

Conference abstract
  1. Pedro Vieira; Nunes, Sara; Preguiça, Inês; Ferreira, Carolina; Alves, André; Almeida, Jani Sofia; Helena Sá; et al. "P054 Imunomodulação intestinal e benefícios metabólicos de uma fibra prebiótica proveniente de desperdícios agrícolas do mirtilo: ensaio em modelo animal de diabetes mellitus tipo 2.". Paper presented in 19º Congresso Português de Diabetes, 2023., Algarve, 2023.
Conference poster
  1. Pedro Vieira; Nunes, Sara; Preguiça, Inês; Ferreira, Carolina; Alves, André; Almeida, Jani; Vera Alves. ""Imunomodulação intestinal e benefícios metabólicos de uma fibra prebiótica proveniente de desperdícios agrícolas do mirtilo: ensaio em modelo animal de diabetes mellitus tipo 2".". Paper presented in 19º Congresso Português de Diabetes, 2023., 2023.
  2. Alves, André; Pedro Vieira; Preguiça, Inês; Ferreira, Carolina; Sara Nunes; Pedro Gomes; Solange Semião. ""Efeito de dietas refinadas na indução de doença metabólica em rato – destaque para o impacto na microbiota intestinal e na função renal".". Paper presented in 19º Congresso Português de Diabetes, 2023., 2023.
  3. Flávio Reis; Preguiça, Inês; Pedro Vieira; Ferreira, Carolina; Alves, André; Sara Nunes; Mónica Zuzarte. ""Upcycling berries' agrowaste into sustainable prebiotics favoring gut mucosal immunity: the case of senescent bluberry leaf".". Paper presented in 3rd International World of Microbiome Conference, 2022., 2022.
Journal article
  1. Ferreira, Carolina; Vieira, Pedro; Sá, Helena; Malva, João; Castelo-Branco, Miguel; Reis, Flávio; Viana, Sofia. "Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases". Frontiers in Immunology 15 (2024): http://dx.doi.org/10.3389/fimmu.2024.1360065.
    Published • 10.3389/fimmu.2024.1360065
  2. Ferreira, Carolina; Pedro Vieira; Helena Sá; João O. Malva; Castelo-Branco, Miguel; Flávio Reis; Sofia Viana. "Polyphenols: Immunonutrients Tipping the Balance of Immunometabolism in Chronic Disease". Frontiers in Immunology (2024):
    Submitted
  3. Ferreira, Carolina; Viana, Sofia D.; Reis, Flávio. "Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update". Microorganisms 9 1 (2020): 53. http://dx.doi.org/10.3390/microorganisms9010053.
    Published • 10.3390/microorganisms9010053
  4. Ferreira, Carolina; Viana, Sofia D.; Reis, Flávio. "Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches". Microorganisms 8 10 (2020): 1514. http://dx.doi.org/10.3390/microorganisms8101514.
    Published • 10.3390/microorganisms8101514

Intellectual property

Patent
  1. Flávio Reis; Sofia Viana. 2021. ""Semi-Solid Formulation for Voluntary Oral Administration of Bioactive Compounds to Rodents".".
    Allowed
Provisional application for patent
  1. 2020. ""Semi-Solid Formulation for Voluntary Oral Administration of Bioactive Compounds to Rodents- Pedido provisório de patente no 116301".".
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/09 (De/Re)myelination dynamics in cuprizone-induced multiple sclerosis: focus on the gut-neuroimmune axis 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
(Lisbon, Portugal)
2024/01/23 Blueberry leaf biomass: a nutraceutical for Multiple Sclerosis’ relief targeting the gut-immune system-CNS axis Meet my Science
CIBB - Center for Innovative Biomedicine and Biotechnology CNC | iCBR | UC-Biotech (Coimbra, Portugal)
2023/02/02 Pro-inflammatory cues towards remyelination: novelty effects of a blueberry leaves-based nutraceutical 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
(Coimbra, Portugal)
2022/11/17 A blueberry-based prebiotic improves gut Th17/Treg imbalance and central impairments in experimental multiple sclerosis National Congress of Neurology
(Aveiro, Portugal)
2022/02/09 A blueberry-based prebiotic strategy improves intestinal Th17/Treg imbalance and central impairments in experimental Multiple Sclerosis 52nd Meeting of the Portuguese Society of Pharmacology, 40thMeeting of Clinical Pharmacology and 21st Meeting of Toxicology
(Porto, Portugal)
2021/02/19 Sub-Cronic Toxicity Evaluation of Green Enzyme-Assisted Processing of Senescent Vaccinium Leaves Biomass in Mice 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of Clinical Pharmacology and 20th Meeting of Toxicology
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/09/01 - 2024/09/30 Preclinical evaluation of the nutraceutical potential of blueberry-based antioxidant fiber in experimental Multiple Sclerosis
Co-supervisor
Masters in Pharmacy (Master)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2021/09/01 - 2022/08/01 Gut-immune-CNS axis modulation in Multiple Sclerosis: An update
Co-supervisor
Bachelor in Pharmacy (Degree)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2020/11/27 - 2021/08/01 Metabolic changes underlying the pathophysiology of multiple sclerosis - new therapeutic opportunities
Co-supervisor
Bachelor in Pharmacy (Degree)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/01/01 - 2023/02/03 Organisation of the 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (2023/02/01 - 2023/02/03)
Congress (Member of the Organising Committee)
CNC.IBILI, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/01/16 - 2023/01/27 RESETageing project
Workshop
RESETageing project aims at enhancing the scientific and innovation competences of University of Coimbra, building an innovation and entrepreneurship environment by nurturing an entrepreneurial and risk-taking spirit among UC students and researchers.
Instituto Pedro Nunes, Portugal
Distinctions

Award

2021 1º prémio no concurso de ideias "From Linear to Circular Ideas" - 1ª Edição da Rede de Campus Sustentável (RCS)
Universidade de Coimbra, Portugal

Universidade Tecnológica Federal do Paraná - Câmpus Medianeira, Brazil

Instituto Politécnico de Castelo Branco, Portugal

Smart Waste Portugal, Portugal

Intraplás, Portugal

Entogreen, Portugal

Delta, Portugal

Laboratório Colaborativo para a Economia Circular, Portugal

Associação Natureza Portugal, Portugal