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PERSONAL DATA: Date and place of birth: 7.April.1954, Sá da Bandeira (Angola) Marital Status: late Candida Rueff (3 children) Nationality: Portuguese PROFESSIONAL CURRENT SITUATION: Professor and Chair of Genetics Coordinator of the Genetics, Oncology and Human Toxicology area Coordinator of the Centre for Toxicogenomis and Human Health Nova Medical School, Universidade Nova de Lisboa . More than 220 internationally published articles . More than 4600 citations (h index = 36). Supervisor of 28 PhD theses . Editor of the volume 'Cancer Drug Resistance- Overviews and Methods' - Springer, New York. ACADEMIC DEGREES AND TITLE: 1990 - Aggregation, Faculty of Medical Sciences, New University of Lisbon 1984 - PhD, Faculty of Medical Sciences, New University of Lisbon (Distinction and Commendation unanimously) 1971-1977: MD, Faculty of Medicine, University of Lisbon (Distinction, 16/20) AWARDS: 2006 - Award 'Encouraging Excellence' - Foundation for Science and Technology - Ministry of Science and Higher Education; 2001 - Award Burdinola Molecular Genetics - Burdinola Foundation (Spain); 1981 - Award Piaui of Medical Sciences - Academy of Sciences of Lisbon; 1978 - 2nd Pfizer Research Prize - Society of Medical Sciences of Lisbon; 1976 - Pfizer Prize for Young Researchers - Society of Medical Sciences of Lisbon. SCIENTIFIC ACADEMIES: Full Member of the Academy of Sciences of Lisbon (Medicine Section); Corresponding Member of the Portuguese Academy of Medicine. ACTIVE MEMBER: American Association for Cancer Research; European Environmental Mutagen Society. ROLES AND FUNCTIONS at UNIVERSITY: 2003-2007 - Vice-Rector of the Universidade Nova de Lisboa (UNL); 2013 to present - Coordinator of the area of Genetics, Oncology and Human Toxicology , Nova Medical School/Faculty of Medical Sciences, UNL; 2014 to present - Coordinator of the Centre for Toxicogenomics and Human Health; 2000 to 2014 - Coordinator of the Centre for Research in Human Molecular Genetics; 1992 to 1999 - Pro-Rector of the Universidade Nova de Lisboa (UNL); 1992 to present - Full Professor of Medicine (genetics), Nova Medical School/Faculty of Medical Sciences, UNL . OTHER ROLES AND OFFICES: Member of Editorial Boards of International Journals : 'Mutation Research' (since 2016); 'Cancer Drug Resistance' (since 2017); Frontiers in Toxicogenomics (since 2019); Member of the National Council of Ethics for the Life Sciences (1991-1996); President of the Portuguese Society of Genetics (1993-2001); Specialized Expert, Carcinogenic, Mutagenic and Teratogenic substances, Directorate-General for the Environment, Consumer Protection and Nuclear Safety (DG XI), Commission of the European Communities, Brussels (1986-1992); Senior Member, Scientific Advisory Committee to Examine the Toxicity and Ecotoxicity of Chemicals, Health and Safety Directorate (DG V, V/E/1), Commission of the European Communities, Luxembourg (1986-1997); National Delegate, COMAC-Applied Biology, Directorate-General for Science, Research and Development (DG XII), Commission of the European Communities, Brussels (1986-1991); Councilor, European Environmental Mutagen Society (1987-1991); Member, Ad-hoc Working Group on dangerous chemicals - Carcinogens, Health and Safety Directorate (DG V), Commission of the European Communities, Luxembourg (1988-2003); Expert Working Group Predictive Medicine / Human Genome Analysis, Directorate-General for Science, Research and Development (DG XII), Commission of the European Communities, Brussels (1988-1991); National Delegate, Advisory Committee on Human Genome Analysis, Directorate-General for Science, Research and Development (DG XII), Commission of the European Communities, Brussels (1991-2003). He was Calouste Gulbenkian fellow at Institut Pasteur , Paris (1980). ACADEMIC PROMOTOR OF 'honoris causa' DOCTORATES : 1988 - Professor François Jacob (Nobel Prize, Institut Pasteur Paris); 2005 - Professor Alain Léonard (Catholic University of Louvain).
Identification

Personal identification

Full name
José Rueff

Citation names

  • Rueff, José
  • J Rueff

Author identifiers

Ciência ID
0E15-908D-EA21
ORCID iD
0000-0002-8456-7295

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Beginner (A1) Intermediate (B1) Beginner (A1)
Italian Beginner (A1) Elementary (A2) Beginner (A1) Elementary (A2) Beginner (A1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
1990
Concluded
Medicina (Título de Agregado)
Major in Medicina Genética
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
1984
Concluded
Medicina (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Proteínas de membrana e cancerigénese" (THESIS/DISSERTATION)
Distinção e Louvor
1977
Concluded
Medicina (Licenciatura)
Universidade de Lisboa Faculdade de Medicina, Portugal
"n.a." (THESIS/DISSERTATION)
Distinção 16 valores
Affiliation

Science

Category
Host institution
Employer
1998/01/08 - Current Researcher (Research) Academia das Ciências de Lisboa, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2014/06/01 - Current Full Professor (University Teacher) Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
1992/12/10 - Current Full Professor (University Teacher) Universidade Nova de Lisboa, Portugal

Positions / Appointments

Category
Host institution
Employer
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2003/03/02 - 2007/11/29 Vice-Rector Universidade Nova de Lisboa, Portugal
1992/08/04 - 1999/04/04 Pro-Rector Universidade Nova de Lisboa, Portugal
Projects

Contract

Designation Funders
2018/10/04 - 2022/07/03 Avaliação detalhada de microRNA circulantes como biomarcadores de diagnóstico e prognóstico em Esclerose Lateral Amiotrófica
PTDC/MEC-NEU/31195/2017
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Centre for Toxicogenomics and Human Health
UID/BIM/00009/2019
Universidade NOVA de Lisboa, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/01/01 - 2015/06/30 Relevância clínica de múltiplos marcadores genéticos na pneumonia por Pneumocystis jirovecii PPc: Novas metodologias de alto rendimento para aplicação à epidemiologia molecular e diagnóstico.
PTDC/SAU-MIC/116716/2010
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/02/01 - 2014/07/31 Mecanismos de bioactivação do fármaco anti-HIV Nevirapina: identificação de metabolitos reactivos e potencial mutagénico
PTDC/QUI-QUI/113910/2009
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 9 - 2011-2012
PEst-OE/SAU/UI0009/2011
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/30 GenFA- Exposição Ocupacional ao Formaldeído. Análise do dano genético e susceptibilidade genética em profissionais dos serviços de Anatomia Patológica
PTDC/SAU-ESA/102367/2008
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 BIOMARCADORES DE EXPOSIÇÃO ALIMENTAR À ACRILAMIDA: RELEVÂNCIA TOXICOLÓGICA PARA O HOMEM
PTDC/SAU-OSM/105572/2008
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 Importância do B-glucano na Pneumonia por Pneumocystis jirovecii PPc: Uma nova ferramenta de diagnóstico.
PTDC/SAU-MII/104231/2008
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/02 - 2012/06/30 Novos SERMs bio-organometálicos - síntese e avaliação do potencial anti-cancerígeno
PTDC/QUI/67522/2006
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/03/01 - 2012/02/29 O estudo de mutações relacionadas com o Síndroma Antley-Bixler na oxireductase do citocromo P450: polimorfismo do CYPOR e o complexo enzimático do citocromo P450
PTDC/SAU-GMG/71911/2006
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2011/04/30 Plantas medicinais angolanas: actividade biológica
PTDC/QUI/66507/2006
Universidade da Beira Interior, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/08/01 - 2011/04/15 Mecanismos de Resistência ao Imatinib em Leucemia Mielóide Crónica
PTDC/SAU-GMG/71720/2006
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/09/05 - 2011/02/28 Nanodiagnóstico: nanossondas de ouro para identificação molecular - aplicação à detecção de aductos de DNA; detecção de agentes patogénicos; expressão génica e quantificação de RNA.
PTDC/SAU-BEB/66511/2006
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/12/31 SHIPs: Inferência de Haplotipos por Parcimónia Pura baseada em Satisfação Proposicional
PTDC/EIA/64164/2006
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2010/01/15 Detecção sensível e selectiva de DNA/RNA baseada em nanopartículas de ouro funcionalizadas - aplicação à detecção de agentes patogénicos; detecção de mutações e quantificação de RNA
PTDC/BIO/66514/2006
Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/01/02 - 2009/10/31 Exposição ao Chumbo. Contribuição para o estudo da sua toxicidade genética e imunológica. Influência dos determinantes genéticos. "ToxPb"
PDCT/SAU-OBS/59821/2004
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade Nova de Lisboa Escola Nacional de Saúde Pública, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/10/15 - 2008/06/30 CANCRO DA MAMA: AVALIAÇÃO DO PAPEL DE CANCERÍGENOS DE ORIGENS AMBIENTAL E ALIMENTAR NA SUA INICIAÇÃO
POCI/QUI/57110/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Monteiro, M.; Rodrigues, A. S.; Vicente, A.; Murias, J.; Martins, C.; Rueff, J.; Borba, H.; Medimond,. Potassium bromate oxidative DNA damage in repair proficient and deficient CHO cell lines. 2007.
  2. Duarte, M. P.; Palma, B. B.; Gilep, A. A.; Laires, A.; Oliveira, J. S.; Usanov, S. A.; Rueff, J.; Kranendonk, M.; Medimond,. The role of protein-protein interactions in the stimulation of the bioactivation by CYP1A2, 2A6 and 2E1 in the presence of cytochrome b5: A new cell system to study cytochrome P450 mediated biotransformation. 2005.
  3. Kranendonk, M.; Ruas, M.; Laires, A.; Rueff, J.. DEVELOPMENT AND PREVALIDATION OF AN ESCHERICHIA-COLI TESTER STRAIN FOR GENOTOXINS. 1994.
  4. Rodrigues, A. S.; Silva, I. D.; Monteiro, M. J.; Caria, H.; Laires, A.; Chaveca, T.; Rueff, J.. ACTIVATION OF PROMUTAGENS BY RAT CYP P450 EXPRESSING V79 CELLS. 1994.
  5. Gaspar, J.; Laires, A.; Rueff, J.. GENOTOXIC FLAVONOIDS AND RED WINE - A POSSIBLE ROLE IN STOMACH CARCINOGENESIS. 1994.
Book chapter
  1. Rueff, José. "Bactérias ‘humanizadas’: expressão de genes humanos em procariotas na detecção de agentes cancerígenos". Academia das Ciências de Lisboa, 2023.
    https://doi.org/doi.org/10.58164/fws3-x092
  2. Rueff, José. "Doenças genéticas na Pintura: a arte parecida com a vida – do Renascimento ao Barroco". Academia das Ciências de Lisboa, 2023.
    https://doi.org/doi.org/10.58164/gs2x-mk64
  3. Rueff, José. "O ensino da Medicina – Algumas Premissas em Busca de Uma Epistemologia do Ensino Médico". Academia das Ciências de Lisboa, 2023.
    https://doi.org/doi.org/10.58164/ysaf-7952
  4. Rueff, José. "Efeitos genéticos das radiações ionizantes". Academia das Ciências de Lisboa, 2023.
    https://doi.org/doi.org/10.58164/cjyq-jy93
  5. Azevedo, Ana; Nunes Silva, Susana; Rueff, José. "Non-receptor Tyrosine Kinases Role and Significance in Hematological Malignancies". In Tyrosine Kinases as Druggable Targets in Cancer. IntechOpen, 2019.
    10.5772/intechopen.84873
  6. Anunciacao, O.; Gomes, B. C.; Vinga, S.; Gaspar, J.; Oliveira, A. L.; Rueff, J.. "A Data Mining Approach for the Detection of High-Risk Breast Cancer Groups". edited by Rocha, M. P.; Riverola, F. F.; Shatkay, H.; Corchado, J. M., 43-51. 2010.
    10.1007/978-3-642-13214-8_6
Book review
  1. Brás, Aldina; Rodrigues, António S; Gomes, Bruno; Rueff, José; NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); Centre for Toxicogenomics and Human Health (ToxOmics). "Down syndrome and microRNAs". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780767/.
    https://doi.org/10.3892/br.2017.1019
Conference abstract
  1. Isabel Barata; Esteves, Francisco; Rueff, José; Kranendonk, Michel. "The role of PGRMC1 in CYP-mediated drug metabolism and its implication in chemotherapy resistance". Paper presented in 3rd NMS Symposium on Chronic Diseases and Translational Science 2021, Lisbon, 2021.
    Published
  2. Inês Saldanha; Esteves, Francisco; Cristina Almeida; Sofia Silva; Rueff, José; Kranendonk, Michel. "CPR protein dynamics and its interaction with microsomal CYPs - the study of caffeine metabolism by CYP1A2". Paper presented in 3rd NMS Symposium on Chronic Diseases and Translational Science 2021, Lisbon, 2021.
    Published
  3. Kranendonk, Michel; Esteves, Francisco; Campelo, Diana; Urban, Philippe; Bozonnet, Sophie; Lautier, Thomas; Rueff, José; Truan, Gilles. "Putative motif in the FMN-domain of human cytochrome P450 oxidoreductase involved in its interaction with structurally diverse redox partner". Paper presented in 21st International Conference on Cytochrome P450: Biochemistry, Biophysics and Biotechnology (ICCP450), Brisbane, 2019.
    Published
  4. Silva Santos, Luís; Gomes, Bruno; Gouveia, Rita; Silva, Susana Nunes; Azevedo, Ana; Camacho, V; Manita, Isabel; et al. "The role of CCNH Val270Ala and other nucleotide excision repair polymorphisms on individual susceptibility towards thyroid cancer". Paper presented in 6th Santorini Conference Biologie Prospective "Systems Biology and Personalized Health Science and Translation", Thira, Santorini, 2012.
    Published • 10.1515/dmdi-2012-0025
  5. Helena Caria; Chaveca, Teresa; Rueff, José. "Aneugenic effects Induced in lymphocytes of progenitors of trissomic 21 children.". Paper presented in 4th Chromosome Segregation and Aneuploidy, Porto, 1998.
    Published
  6. Helena Caria; Chaveca, Teresa; Rueff, José. "Induction of acrocentric chromosomes loss by Colchicine". Paper presented in 26th Meeting of EEMS, Roma, 1996.
    Published
  7. Helena Caria; Chaveca, Teresa; Rueff, José; Rita Ponce. "Analysis of Quercetin induced-micronuclei by CREST and FISH techniques.". Paper presented in 26th Meeting of EEMS, Roma, 1996.
    Published
  8. Helena Caria; Chaveca, Teresa; Laires, António; Rueff, José. "Analysis of micronucleated cells by CREST staining: the clastogenicity of quercetin". Paper presented in Chromosome Segregation and Aneuploidy: An International Conference, Sorrento, 1995.
    Published
  9. Helena Caria; Chaveca, Teresa; Rueff, José; Ana Rita Quintas. "Chromosome aneuploidy in Down¿s syndrome: The role of poly(ADP-ribose)polymerase in the induction of SCE¿s and MN in vitro". Paper presented in International Down¿s syndrome Meeting, Antalya, 1995.
    Published
  10. Helena Caria; Chaveca, Teresa; Rueff, José; Susana Neves; Ana Rita Quintas. "Chromosome Aneuploidy: the effect of Mitomycin C using Micronuclei assay". Paper presented in XXX Jornadas Luso Espanholas de Genética,, Lisboa, 1995.
    Published
  11. Helena Caria; Chaveca, Teresa; Ricardo Coelho; Rueff, José. "Preliminary Results with the Usage of C - and N - Banding of Micronuclei in Binucleated Human Lymphocytes.". Paper presented in 23nd Meeting of EEMS, Barcelona, 1993.
    Published
  12. Helena Caria; Chaveca, Teresa; Rueff, José; Laires, António; João Tiago Mexia. "The Induction of Micronuclei by Quercetin. In Proc. Chromosome Segregation and Aneuploidy". Paper presented in A NATO Advanced Research Workshop, Heraclion, Creta, 1992.
    Published
  13. António Rodrigues; Rueff, José; Antonio Laires; Jorge Gaspar; Helena Caria; Chaveca, Teresa. "Activation of Premutagens Using Different Metabolic Systems.". Paper presented in 20th EC Contact Group Meeting, Estoril, 1991.
    Published
  14. Helena Caria; Micheline Kirsch Volders; Fialho, Graça; Rueff, José. "Cinética dos Micronúcleos ao longo do ciclo celular: frequências, áreas e conteúdos em DNA". Paper presented in XXVI Jornadas Luso Espanholas de Genética, Coimbra, 1991.
    Published
Conference paper
  1. Santos, Luís Silva; Gil, Otávia Monteiro; Silva, Susana Nunes; Gomes, Bruna Costa; Ferreira, Teresa; Limbert, Edward; Rueff, José. "Excision repair SNPs may influence the extent of DNA damage from radioiodine therapy in lymphocytes from thyroid cancer patients". 2023.
  2. Gomes, D.P.; Sequeira, I.J.; Figueiredo, C.; Rueff, J.; Brás, A.. "The human chromosomal fragile sites more often involved in constitutional deletions and duplications - A genetic and statistical assessment". 2016.
    10.1063/1.4968684
  3. Azevedo, Ana Paula; Silva, Susana Nunes; Lima, João P. de; Reichert, Alice; Lima, Fernando; Júnior, Esmeraldina; Rueff, José. "Apoptosis deregulation expression in Philadelphia-negative Myeloproliferative Neoplasms in a Portuguese population". 2016.
  4. Azevedo, Ana P.; Silva, Susana N.; Reichert, Alice; Lima, Fernando; Júnior, Esmeraldina; Rueff, José; Gaspar, Jorge F.; et al. "Identification of genetic determinants associated with susceptibility and therapeutic efficacy in Philadelphia-negative Myeloproliferative Neoplasms". 2015.
  5. Sequeira, Inês J.; Gonçalves, Juliana; Moreira, Elsa; Mexia, João T.; Rueff, José; Brás, Aldina; DM - Departamento de Matemática; et al. "Genetic and statistical study of HIV integration in the human genome". 2013.
    10.1063/1.4825619,title
Conference poster
  1. Barata, Isabel S; Bruno Costa Gomes; António Sebastão Rodrigues; Rueff, José; Kranendonk, Michel; Esteves, Francisco. "Differential Expression of Phase I Drug Metabolism Enzymes in Doxorubicin Resistant Breast Cancer Cells". Paper presented in 26th Annual Meeting Sociedade Portuguesa de Genética Humana, 2022.
  2. Gonçalves, Juliana; Moreira, Elsa; Sequeira, Inês Jorge; Sebastião, Rodrigues; Rueff, José; Brás, Aldina. "Study of preferential integration targets of HIV in the human Genome ¿ a genetic and statistical analysis". Paper presented in 1º Workshop de Genética, 2015.
  3. Pingarilho, Marta; Oliveira, Nuno G.; Martins, Célia; Bruno Costa Gomes; Fernandes, Ana S.; Martins, Vanda; Silva, Anatália R.; Rueff, José; Gaspar, Jorge F.. "Abstract 4199: Genetic variation in the in vitro genotoxic response to glycidamide and gene expression of DNA repair genes". Paper presented in AACR 102nd Annual Meeting 2011, 2011.
    10.1158/1538-7445.am2011-4199
  4. Mendonça, Dina I.; Vieira, Liliana; Fernandes, Nelson; Mendonça, António J.; Domingues, Fernanda; Granadeiro, Luiza; Célia Martins; et al. "Medicinal plants from Angola: From citotoxicity to bactericide activity". Paper presented in 21st International Symposium on Medicinal Chemistry (EFMC-ISMC), 2010.
  5. Miranda, Cláudia C.; Martins, Célia; Doran, Carolina; Cabral, Maria Guadalupe; Dinis, Joana; Gromicho, Marta; Laires, António; et al. "Study of cell cycle, apoptosis and dna damage, in human K562 leukaemia cells: effect of the alkenylbenzene myristicin". Paper presented in 10th International Conference on Environmental Mutagens, 2009.
Edited book
  1. Rueff, José; Rodrigues, António Sebastião. Cancer Drug Resistance. Springer New York. 2016.
    10.1007/978-1-4939-3347-1
Journal article
  1. Gomes BC; Peixinho N; Pisco R; Gromicho M; Pronto-Laborinho AC; Rueff J; de Carvalho M; Rodrigues AS. "Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients.". Molecular neurobiology (2023): http://europepmc.org/abstract/med/37531027.
    10.1007/s12035-023-03520-7
  2. Esteves F; Cristina M.M. Almeida; Sofia Silva; Inês de Almeida Mateus da Silva Saldanha; Philippe Urban; Jose Rueff; Denis Pompon; Truan; M Kranendonk. "Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/7/1083.
    10.3390/biom13071083
  3. Barata R; Fila M; Dalla-Vale F; Bogarin R; Nunes P; Ramalho J; Rueff J; Calado J. "Performance of the ACMG-AMP criteria in a large familial renal glucosuria cohort with identified SLC5A2 sequence variants.". Clinical genetics (2023): http://europepmc.org/abstract/med/37349938.
    10.1111/cge.14395
  4. Conde J; Langer R; Rueff J. "mRNA therapy at the convergence of genetics and nanomedicine.". Nature nanotechnology (2023): http://europepmc.org/abstract/med/36932293.
    10.1038/s41565-023-01347-w
  5. Lourenço RA; Lança M; Monteiro Gil O; Cardoso J; Lourenço T; Pereira-Leal JB; Rodrigues AS; Rueff J; Nunes Silva S. "BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer.". Molecular medicine reports (2023): http://europepmc.org/abstract/med/37232349.
    10.3892/mmr.2023.13023
  6. Zhou Y; Russo J; Rueff J; Pires MAM; de Castro GB. "Genetic determinants and absence of breast cancer in Xavante Indians in Sangradouro Reserve, Brazil.". Scientific reports (2023): http://europepmc.org/abstract/med/36702877.
    10.1038/s41598-023-28461-y
  7. Barata IS; Gomes BC; Rodrigues AS; Rueff J; Kranendonk M; Esteves F. "The Complex Dynamic of Phase I Drug Metabolism in the Early Stages of Doxorubicin Resistance in Breast Cancer Cells.". Genes (2022): http://europepmc.org/abstract/med/36360213.
    10.3390/genes13111977
  8. Ventura C; Torres V; Vieira L; Gomes B; Rodrigues AS; Rueff J; Penque D; Silva MJ. "New "Omics" Approaches as Tools to Explore Mechanistic Nanotoxicology.". Advances in experimental medicine and biology (2022): http://europepmc.org/abstract/med/35583645.
    10.1007/978-3-030-88071-2_8
  9. Francisco Esteves; José Rueff; Michel Kranendonk. "The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family". Journal of Xenobiotics (2021): https://doi.org/10.3390/jox11030007.
    10.3390/jox11030007
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  227. Rueff, J.; Laires, A.; Gomes, M.I.; Borba, H.; Magalhães, J.; Halpern, M.. "Mutagenicity in urine of workers in naval industry.". Progress in clinical and biological research 109 (1982): 443-452. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020347446&partnerID=MN8TOARS.
  228. Gomes, M.I.; Rueff, J.; Halpern, M.; Gomes MI; Rueff J; Halpern M. "VLDL-associated mutagenic activity.". British Journal of Cancer 45 4 (1982): 646-647. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020121195&partnerID=MN8TOARS.
    10.1038/bjc.1982.103
  229. Laires, A.; Borba, H.; Rueff, J.; Gomes, M.I.; Halpern, M.. "Urinary mutagenicity in occupational exposure to mineral oils and iron oxide particles". Carcinogenesis 3 9 (1982): 1077-1079. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020376568&partnerID=MN8TOARS.
  230. Laires A; Borba H; Rueff J; Gomes MI; Halpern M. "Urinary mutagenicity in occupational exposure to mineral oils and iron oxide particles.". (1982): http://europepmc.org/abstract/med/7139865.
    10.1093/carcin/3.9.1077
  231. Rueff J; Laires A; Gomes MI; Borba H; Magalhães J; Halpern M. "Mutagenicity in urine of workers in naval industry.". (1982): http://europepmc.org/abstract/med/7167556.
Thesis / Dissertation
  1. Azevedo, Ana Paula da Silva. "Genetic susceptibility to myeloproliferative neoplasms and therapeutic efficacy". PhD, 2018. http://hdl.handle.net/10362/31970.
  2. André, Maria do Rosário Gomes. "Exploring the role of Interleukin-6 and other host-associated factors in tumor progression and metastasis development". PhD, 2017. http://hdl.handle.net/10362/20388.
  3. Martins, Célia Maria da Silva. "Study of the natural alkenylbenzenes compounds: mechanisms of DNA lesions and implications for humana health". PhD, 2017. http://hdl.handle.net/10362/20115.
  4. Gomes, Bruno Daniel da Costa. "MicroRNA involvement in breast cancer susceptibility and progression". PhD, 2016. http://hdl.handle.net/10362/19662.
  5. Carmona, Bruno Filipe Sousa. "Caracterização do papel dos genes TYMS e MTR no desenvolvimento de Cancro Colo-Rectal". PhD, 2015. http://hdl.handle.net/10362/14742.
  6. Lopes, Maria Rita Rueff Negrão Mendonça. "Emotional contagion in voice-to-voice service encounters: a dynamic approach to the influence of customers on employees’ behavior and welfare". PhD, 2015. http://hdl.handle.net/10071/10000.

Other

Other output
  1. Temporalidade. info:eu-repo/semantics/publishedVersion. 2023. Pereira, Artur Torres; Rueff, José. http://hdl.handle.net/10400.26/45180.
    https://doi.org/10.58164/2sf2-mg21
  2. Pandemia SARS-CoV-2. info:eu-repo/semantics/publishedVersion. 2023. Rueff, José; Soares, Jorge; Miguel, José Pereira; Rodrigues, Fernando Carvalho. http://hdl.handle.net/10400.26/46498.
    https://doi.org/10.58164/tazm-ym30
Activities

Association member

Society Organization name Role
1998/01/08 - Current Academia das Ciências de Lisboa Académico Efectivo da Classe de Ciências, Secção de Medicina
Distinctions

Other distinction

2006 Distinguished with 'Estímulo à Excelência'
2001 IX Research Prize Burdinola - Area of molecular genetics
1981 Piaui Prize for Medical Sciences
1978 2nd Research Prize Pfizer
1976 Prize Pfizer for Young Researchers