Nuno Gonçalo Pereira Mira (0E15-F489-CFC5)

Curriculum Vitae

Nuno Gonçalo Pereira Mira

During the course of this scientific career Dr Mira has edited four research topics in international journals with peer-review, and is author/co-author of 2 book chapters, 72 published research articles (33 published in the last 5 years of activity, 20 as corresponding author) and 3 articles published in the proceeding of an international conference. He is also author/co-author of 111 communications in national and international meetings, out of which 27 were in the form of oral communications. According with ISI (https://www.webofscience.com/wos/author/record/E-2965-2012), Dr Mira has an h-index of 29 his publications being cited 3171 times (in 2254 citing articles). According with GoogleScholar classification (https://scholar.google.pt/citations?user=0Dnh0igAAAAJ). Dr Mira has an h-index of 34 being his publications cited 4930 times. His scientific activity is developed in the areas of : i) Gene and genomic regulation studies in Yeasts to unveil relevant aspects of their physiology and/or patho-physiology, as well as relevant ecological interactions with other species, aiming to solve pressing issues in industrial biotechnological processes and in health; ii) Development of new therapies against fungal infections, in particular those caused by Candida spp, through the engineering of tailored-made materials, design of new chemicals and development of antagonistic probiotics; iii) Exploitation of Saccharomyces cerevisae and non-conventional Yeasts as cell factories for the production of add-value chemicals (including those that are "new-to-nature") exploring systems- and synthetic biology-based approaches supported by computational metabolic modelling; Dr Mira is/was PI of 9 research projects (8 nationally funded, 1 funded in the framework of the 6th Era Net in Industrial Biotechnology), is member of two international networks (one funded within the framework of the EraSynBio Twinning activity for which Dr Mira was PI and the other funded by CAPES-Print, in Brasil) and was national coordinator of 1 COST action. He is/was team member of 11 research projects for which he was not PI. He is/was supervisor/co-supervisor of 10 PhD thesis, 39 MsC thesis and 5 BsC thesis.

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Identification

Personal identification

Full name: Nuno Gonçalo Pereira Mira

Citation names

Mira, NP
Mira, Nuno Pereira

Author identifiers

Ciência ID: 0E15-F489-CFC5
ORCID iD: 0000-0001-7556-0385
Google Scholar ID: 0Dnh0igAAAAJ
Researcher Id: E-2965-2012

Email addresses

nuno.mira@tecnico.ulisboa.pt (Professional)

Telephones

Telephone

218417233 (Professional)

Addresses

Instituto Superior Técnico, Department of Bioengineering. Avenida Rovisco Pais, Torre Sul, Piso 6, 1049, Lisboa, Lisboa, Portugal (Professional)

Websites

https://sites.google.com/view/nuno-p-mira-research/ (Professional)

Knowledge fields

Natural sciences - Biological Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)	Intermediate (B1)

Education

	Degree	Classification
2008 Concluded	Programa doutoral em Biotecnologia (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal "Adaptation and resistance to weak acid food preservatives in Saccharomyces cerevisiae: role of Haa1p- and Rim101p-signalling pathways" (THESIS/DISSERTATION)	Approved with unanimity
2004 Concluded	Licenciatura Química - Perfil Bioquímica (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal "Study of resistance and adaptation mechanisms to the herbicide 2,4-dicholorophenoxyacetic acid (2,4-D) in the yeast Saccharomyces cerevisiae suggested by transcriptomic analysis" (THESIS/DISSERTATION)	17 valores

Affiliation

Teaching in Higher Education

	Category Host institution	Employer
2023/06 - Current	Associate Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal

2011/11/14 - 2023/05	Assistant Professor (University Teacher)	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/02/01 - 2011/11/14	Invited Assistant (University Teacher)	Instituto Piaget, Portugal

Others

	Category Host institution	Employer
2009/01/01 - 2011/11/14	Post-doc	Instituto de Biotecnologia e Bioengenharia, Portugal

2004/10/01 - 2008/12/12	PhD Student	Instituto de Biotecnologia e Bioengenharia, Portugal

2003/09/01 - 2004/07/30	Master student	Instituto de Biotecnologia e Bioengenharia, Portugal

Projects

Contract

	Designation	Funders
2023/03/01 - Current	SMARTWINE 2.0 - Tailoring 2-in-1 new Yeast starter cultures for production of distinct “greenly-preserved” wines 2022.06777.PTDC Principal investigator Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/10/01 - Current	TRAMONTE – Valorização dos recursos biológicos do interior Norte: a Tramazeira como case-study PD21-000013 Principal investigator Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Fundação LaCaixa BPI Lisboa Ongoing
2017/04 - Current	LactoCan – Exploring the interference between Candida spp. and Lactobacilii to foster the development of non-conventional antifungal therapies PTDC/BIA-MIC/31515/2017 Principal investigator	Concluded
2021/05 - 2023/07	PHARMAPITOX - Development of a container and protocol for purification of apitoxin envisaging its application in the pharma and cosmetics industry LISBOA-01-0247-FEDER-113540 Principal investigator Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Ongoing
2016/04 - 2019/09	TTRAFFIC – Toxicity and Transport for Fungal Production of Industrial Compounds ERA-IB-2-6/0003/2014 Principal investigator	Concluded
2016/04 - 2019/09	SMARTWINE – Smarter wine fermentations: integrating Omic-tools for the development of novel mixed-starter cultures for tailored-made wine production PTDC/AGR-TEC/3315/2014 Principal investigator	Concluded
2016 - 2018	CANTROL-Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches PTDC/BBB-BIO/4004/2014 Researcher	Concluded
2015 - 2016	IST-NFS interaction Grant: Towards the development of sustainable bioprocesses for microbial production of carboxylic acids using renewable raw materials, IST-NFS grant awarded by FLAD Principal investigator	Concluded
2015 - 2016	PhysBioFFM EXPL/FIS-NAN/1395/2013 Researcher	Concluded
2014 - 2016	PANCANDIDA - Towards the development of novel diagnosis tools for the early detection of invasive infections caused by C. albicans and C. glabrata PANCANDIDA Principal investigator	Concluded
2014 - 2014	LEVITA-Towards sustainable microbial production of itaconic and levulinic acids, Twinning program of the EraSynBio research program LEVITA Principal investigator	Concluded
2010 - 2013	INTACT: Integral Engineering of Acetic Acid Tolerance in Yeast ERA -IB/0002/2010 Researcher	Concluded
2009 - 2013	QCMTF-Biosensor platform for transcription factor DNA binding activity detection PTDC/EBB-EBI/108517/2008 Researcher	Concluded
2009 - 2012	ZygoSacAR-Mechanistic insights into acetic acid resistance in food spoilage yeasts: from the experimental model Saccharomyces cerevisiae to Zygosaccharomyces spp PTDC/AGR-ALI/102608/2008 Researcher	Concluded
2009 - 2012	ADHRES signature: expression profile of genes involved in ADHesion and RESistance to antibiotics and biofilms in Pseudomonas aeruginosa, P. putida e Burkholderia cenocepacia ERA-PTG/SAU/0001/2008 Researcher	Concluded
2007 - 2010	Invasive vs chronic infection in patients with cystic fibrosis by bacteria of Burkholderia cepacia complex PTDC/SAU-MII/69591/2006 Researcher Instituto de Biotecnologia e Bioengenharia, Portugal	Concluded

Other

	Designation	Funders
2019/04 - 2023/10	EuroMicropH - Understanding and exploiting the impacts of low pH on micro-organisms EuroMicropH Principal investigator	Concluded
2015 - 2016	ITACYEAST - Exploring a molecular systems biology approach to implement yeast-based processes for production of itaconic acid from renewable carbon sources ITACYEAST Principal investigator	Concluded

Outputs

Publications

Conference abstract	Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Butler, Geraldine; Mira, Nuno Pereira; Azeredo, Joana; Henriques, Mariana; Silva, Sónia. Corresponding author: Silva, Sónia. "Progesterone modulates Candida albicans biofilm formation and expression". Paper presented in EUROBIOFILMS 2017, Amsterdam, 2017. Published Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Butler, Geraldine; Mira, Nuno Pereira; Azeredo, Joana; Henriques, Mariana; Silva, Sónia. "Candida albicans vulvovaginal biofilm response to progesterone: genes involved". Paper presented in Biofilms 7 - Microbial Works of Art, Porto, 2016. Published
Conference paper	Dos Santos, S.C.; Palma, M.; Tenreiro, S.; Mira, N.P.; Moreira, A.; Sá-Correia, I.. "Identification of targets and mechanisms of resistance to imatinib and quinine using a molecular systems biology approach". 2011. 10.1109/ENBENG.2011.6026077 Madeira, A.; Mira, N.P.; Santos, P.M.; Coutinho, C.P.; Pinto-De-Oliveira, A.; Moreira, A.S.; Roma-Rodrigues, C.; Sá-Correia, I.. "OMICS approaches to reveal Burkholderia cenocepacia adaptive strategies to long-term residence in the lungs of cystic fibrosis patients under antibiotic therapy". 2011. 10.1109/ENBENG.2011.6026074
Conference poster	Seixas, Isabel; Santos, Diogo; Mira, Nuno Pereira; Mendes-Ferreira, Ana. "Exploring Hanseniaspora guilliermondii as a cell factory: insights into acetate ester production and ethanol tolerance mechanisms". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023. Valério, Joana; Santos, Diogo; Pinheiro, Maria Joana; Vergara, Gabriela; Seixas, Natália; Mil-Homens, Dalila; Fialho, Arsénio; et al. "Is there a role for Tramazeira tree in offering alternatives for the treatment of infections caused by Candida species?". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023. Araújo, D; Silva, AR; Oliveira, A; Mira, NP; Silva, S; Almeida, C; Castro, J. "Lactobacillus strains to counteract Enterotoxigenic Escherichia coli (ETEC) infection by using a Galleria mellonella in vivo model". Paper presented in Microbiotec'23 - Congress of Microbiology and Biotechnology, Covilhã, 7-9th December (presenting author)., 2023. Sousa, João; Mira, Nuno Pereira; Tenreiro, Rogério; Alexandra Mendes Ferreira. "The effect of pH on Metschnikowia pulcherrima antagonistic properties". Paper presented in Microbial Stress 2023, 2023. Vila-Santa, Ana; Islam, Ahsanul ; Ferreira, Frederico; Prather, Kristala; Mira, Nuno Pereira. "Pathway prospection for theimplementation of microbe-based production of levulinic acid: a computational approach". Paper presented in 1st OpenMeeting EuroMicropH, 2019. Vila-Santa, Ana; Lúcio, João; Sun, Wan; Correia, Joana; Marques, Nuno; Faria, Nuno; Vinga, Susana; et al. "Towards sustainable Yeast-based production of itaconic acid". Paper presented in 7th Conference on Physiology of Yeast and Filamentous Fungi (PYFF), 2019. Vila-Santa, Ana; Moita, Raquel; Rodrigues, Nicole; Brito, Tiago ; Carvalho, Carla; Mira, Nuno Pereira. "Chemogenomic and transcriptomic analysis of Saccharomyces cerevisiae response and tolerance to itaconic acid stress.". Paper presented in 7th Conference on Physiology of Yeast and Filamentous Fungi (PYFF), 2019. Henriques, Sílvia F.; Mira, NP; Isabel Sá-Correia. "Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to formic acid". Paper presented in 6th Conference on Physiology of Yeasts and Filamentous Fungi, Lisbon, Portugal, 2016. Vila-Santa, Ana; Moita, Raquel; Rodrigues, Nicole; Lúcio, João; Carvalho, Carla; Henriques, Sílvia; Sá-Correia, Isabel; Mira, Nuno Pereira. "Exploring a molecular systems biology approach to setup Saccharomyces cerevisiae as a cell factory for the production of itaconic acid.". Paper presented in Microbiotec15, 2015. Moita, R; Henriques, Sílvia F.; Isabel Sá-Correia; Mira, NP. "A chemogenomic analysis on Saccharomyces cerevisiae tolerance to itaconic acid". Paper presented in Professsor Nicolau van Uden, Poster P17, Lisboa, 2014. Henriques, Sílvia F.; Mira, NP; Santos, SC; Palma, M; Isabel Sá-Correia. "Haa1p-dependent regulatory network of the yeast response to acetic acid stress.". Paper presented in Systems Biology: Networks, 2011. Mira, NP; Henriques, Sílvia F.; Keller, G; Windge, DR; Sá-Correia, I. "Role of the Rpd3L histone deacetylase complex in the control of Saccharomyces cerevisiae transcriptional response to acetic acid stress mediated by Haa1p". Paper presented in 9th EMBL Conference on Transcription and Chromatin remodeling, Heidelberg (Book of Abstracts P168), 2010. Mira, NP; Henriques, Sílvia F.; Keller, G; Matos, Rute; Arraiano, C; Winge, DR; Sá-Correia, I. "Gene expression regulation mediated by the acetic acid-responsive yeast transcription factor Haa1p: DNA binding site and role of copper in DNA binding". Paper presented in XVIII Jornadas de Biologia de Leveduras Professor Nicolau van Uden*, 2010.
Journal article	Nuno Pereira Mira; Robert Marshall; Maria Joana F Pinheiro; Ralf Dieckmann; Sascha Al Dahouk; Nevena Skroza; Karolina Rudnicka; Peter A Lund; Daniela De Biase. "On the potential role of naturally occurring carboxylic organic acids as anti-infective agents: opportunities and challenges". International Journal of Infectious Diseases (2024): https://doi.org/10.1016/j.ijid.2024.01.011. 10.1016/j.ijid.2024.01.011 Pedro, Nuno A; Mira, Nuno P. "A molecular view on the interference established between vaginal Lactobacilli and pathogenic Candida species: Challenges and opportunities for the development of new therapies". Microbiological Research (2024): https://publons.com/wos-op/publon/66070144/. 10.1016/J.MICRES.2024.127628 Isabel Seixas; Diogo Santos; Isabel Vasconcelos; Nuno P Mira; Ana Mendes-Ferreira. "Insights into the transcriptional regulation of poorly characterized alcohol acetyltransferase-encoding genes (HgAATs) shed light into the production of acetate esters in the wine yeast Hanseniaspora guilliermondii". FEMS Yeast Research (2023): http://dx.doi.org/10.1093/femsyr/foad021. 10.1093/femsyr/foad021 Patrícia Lage; Bárbara B. Coelho; Nuno P. Mira; Ana Mendes-Ferreira. "A Genome-Wide Phenotypic Analysis of Saccharomyces cerevisiae’s Adaptive Response and Tolerance to Chitosan in Conditions Relevant for Winemaking". Fermentation 9 2 (2023): 172-172. http://dx.doi.org/10.3390/fermentation9020172. 10.3390/fermentation9020172 Sara B Salazar; Maria Joana F Pinheiro; Danielle Sotti-Novais; Ana R Soares; Maria M Lopes; Teresa Ferreira; Vitória Rodrigues; et al. "Disclosing azole resistance mechanisms in resistant Candida glabrata strains encoding wild-type or gain-of-function CgPDR1 alleles through comparative genomics and transcriptomics". G3 Genes\|Genomes\|Genetics (2022): https://doi.org/10.1093/g3journal/jkac110. 10.1093/g3journal/jkac110 Aleksandra Djukic-Vukovic; Nuno P. Mira; Jana Sedlakova-Kadukova; Daniela De Biase; Peter A. Lund. "Editorial: Microbial Stress: From Model Organisms to Applications in Food, Microbiotechnology and Medicine". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.945573. 10.3389/fmicb.2022.945573 Miguel Figueiredo Nascimento; Nuno Marques; Joana Correia; Nuno T. Faria; Nuno P. Mira; Frederico Castelo Ferreira. "Integrated perspective on microbe-based production of itaconic acid: From metabolic and strain engineering to upstream and downstream strategies". Process Biochemistry 117 (2022): 53-67. http://dx.doi.org/10.1016/j.procbio.2022.03.020. 10.1016/j.procbio.2022.03.020 Stephanie Almada; Luisa Maia; João C. Waerenborgh; Bruno JC Vieira; Nuno P. Mira; Elisabete Silva Geraldes; Fátima Cerqueira; Eugénia Pinto; Luis G. Alves. "Cyclam-based iron and copper complexes: synthesis, characterization and application as antifungal agents". New Journal of Chemistry 46 35 (2022): 16764-16770. http://dx.doi.org/10.1039/d2nj03161b. 10.1039/d2nj03161b Maria J. Tavares; Ulrich Güldener; Ana Mendes-Ferreira; Nuno P. Mira. "Genome sequencing, annotation and exploration of the SO2-tolerant non-conventional yeast Saccharomycodes ludwigii". BMC Genomics (2021): https://doi.org/10.1186/s12864-021-07438-z. 10.1186/s12864-021-07438-z Vila-Santa, Ana; Mendes, Fernão C.; Ferreira, Frederico C.; Prather, Kristala L. J.; Mira, Nuno P.. "Implementation of Synthetic Pathways to Foster Microbe-Based Production of Non-Naturally Occurring Carboxylic Acids and Derivatives". Journal of Fungi 7 12 (2021): 1020. http://dx.doi.org/10.3390/jof7121020. 10.3390/jof7121020 Pinheiro, M. Joana F.; Costa, Joana P.; Marques, Fernanda; Mira, Nuno P.; Carvalho, M. Fernanda N. N.; Alves, Marta M.. "Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans". Antibiotics 10 6 (2021): 638. http://dx.doi.org/10.3390/antibiotics10060638. 10.3390/antibiotics10060638 Ana Vila-Santa; M. Ahsanul Islam; Frederico C. Ferreira; Kristala L. J. Prather; Nuno P. Mira. "Prospecting Biochemical Pathways to Implement Microbe-Based Production of the New-to-Nature Platform Chemical Levulinic Acid". ACS Synthetic Biology 10 4 (2021): 724-736. https://doi.org/10.1021/acssynbio.0c00518. 10.1021/acssynbio.0c00518 Lund, Peter A.; De Biase, Daniela; Liran, Oded; Scheler, Ott; Mira, Nuno Pereira; Cetecioglu, Zeynep; Fernández, Estefanía Noriega; et al. "Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation". Frontiers in Microbiology 11 (2020): http://dx.doi.org/10.3389/fmicb.2020.556140. 10.3389/fmicb.2020.556140 Sun, Wan; Vila-Santa, Ana; Liu, Na; Prozorov, Tanya; Xie, Dongming; Faria, Nuno Torres; Ferreira, Frederico Castelo; Mira, Nuno Pereira; Shao, Zengyi. "Metabolic engineering of an acid-tolerant yeast strain Pichia kudriavzevii for itaconic acid production". Metabolic Engineering Communications 10 (2020): e00124. 10.1016/j.mec.2020.e00124 Wierckx, Nick; Agrimi, Gennaro; Lübeck, Peter Stephensen; Steiger, Matthias G.; Mira, Nuno Pereira; Punt, Peter J.. "Metabolic specialization in itaconic acid production: a tale of two fungi". Current Opinion in Biotechnology 62 (2020): 153-159. 10.1016/j.copbio.2019.09.014 Gonçalves, Bruna; Bernardo, Ruben; Wang, Can; Schröder, Markus S.; Pedro, Nuno A.; Butler, Geraldine; Azeredo, Joana; et al. "Effect of progesterone on Candida albicans biofilm formation under acidic conditions: A transcriptomic analysis". International Journal of Medical Microbiology 310 3 (2020): 151414. 10.1016/j.ijmm.2020.151414 Andrade, Ricardo; Doostmohammadi, Mahdi; Santos, João L.; Sagot, Marie-France; Mira, Nuno P.; Vinga, Susana. "MOMO - multi-objective metabolic mixed integer optimization: application to yeast strain engineering". BMC Bioinformatics 21 1 (2020): 10.1186/s12859-020-3377-1 Salazar, Sara B.; Simões, Rita S.; Pedro, Nuno A.; Pinheiro, Maria Joana; Carvalho, Maria Fernanda N. N.; Mira, Nuno P.. "An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains". Journal of Fungi 6 1 (2020): 23. 10.3390/jof6010023 Lage, Patrícia; Sampaio-Marques, Belém; Ludovico, Paula; Mira, Nuno P.; Mendes-Ferreira, Ana. "Transcriptomic and chemogenomic analyses unveil the essential role of Com2-regulon in response and tolerance of Saccharomyces cerevisiae to stress induced by sulfur dioxide". Microbial Cell 6 11 (2019): 509-523. 10.15698/mic2019.11.697 Esteves; Barbosa; Vasconcelos; Tavares; Mendes-Faia; Mira; Mendes-Ferreira. "Characterizing the Potential of the Non-Conventional Yeast Saccharomycodes ludwigii UTAD17 in Winemaking". Microorganisms 7 11 (2019): 478. http://dx.doi.org/10.3390/microorganisms7110478. 10.3390/microorganisms7110478 Souza, José António Santos; Alves, Marta M; Barbosa, Debora Barros; Lopes, Maria Manuel; Pinto, Eugénia; Figueiral, Maria Helena; Delbem, Alberto Carlos B; Mira, Nuno Pereira. "Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes". Medical Mycology (2019): 10.1093/mmy/myz094 Costa, Joana P.; Pinheiro, M. Joana F.; Sousa, Sílvia A.; Botelho do Rego, Ana M.; Marques, Fernanda; Oliveira, M. Conceição; Leitão, Jorge H.; P. Mira, Nuno; N. N. Carvalho, M. Fernanda. "Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains". Antibiotics 8 3 (2019): 144. 10.3390/antibiotics8030144 Lourenco, Andreia; Pedro, Nuno Alexandre; Salazar, Sara Barbosa; Mira, Nuno Pereira. "Effect of Acetic Acid and Lactic Acid at Low pH in Growth and Azole Resistance of Candida albicans and Candida glabrata". Frontiers in Microbiology 9 (2019): 10.3389/fmicb.2018.03265 Cavalheiro, Mafalda; Costa, Catarina; Silva-Dias, Ana; Miranda, Isabel M.; Wang, Can; Pais, Pedro; Pinto, Sandra N.; et al. "A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate". Antimicrobial Agents and Chemotherapy 63 1 (2019): 10.1128/AAC.00995-18 Seixas, Isabel; Barbosa, Catarina; Mendes-Faia, Arlete; Guldener, Ulrich; Tenreiro, Rogerio; Mendes-Ferreira, Ana; Mira, Nuno P. "Genome sequence of the non-conventional wine yeast Hanseniaspora guilliermondii UTAD222 unveils relevant traits of this species and of the Hanseniaspora genus in the context of wine fermentation.". DNA research : an international journal for rapid publication of reports on genes and genomes (2018): 10.1093/dnares/dsy039 Tavares, Maria J.; Gueldener, Ulrich; Esteves, Marcos; Mendes-Faia, Arlete; Mendes-Ferreira, Ana; Mira, Nuno P.. "Genome Sequence of the Wine Yeast Saccharomycodes ludwigii UTAD17". Microbiology Resource Announcements 7 18 (2018): 10.1128/MRA.01195-18 Alves, Marta M.; Marques, Luisa M.; Nogueira, Isabel; Santos, Catarina F.; Salazar, Sara B.; Eugenio, Sonia; Mira, Nuno P.; Montemor, M. F.. "In silico, in vitro and antifungal activity of the surface layers formed on zinc during this biomaterial degradation". Applied Surface Science 447 (2018): 401-407. 10.1016/j.apsusc.2018.03.164 Alves, Marta M.; Cunha, Diana V.; Santos, Catarina F.; Mira, Nuno P.; Montemor, Maria F.. "Microstructured ZnO-rod like coating prevents biofilm formation prompted by pathogenic Candida spp.". Ceramics International 44 4 (2018): 4467-4472. 10.1016/j.ceramint.2017.11.150 L. M. Marques; M. M. Alves; S. Eugénio; S. B. Salazar; N. Pedro; L. Grenho; N. P. Mira; et al. "Potential anti-cancer and anti-Candida activity of Zn-derived foams". Journal of Materials Chemistry B 6 18 (2018): 2821-2830. 10.1039/C7TB02726E Godinho, Claudia P.; Mira, Nuno P.; Cabrito, Tnia R.; Teixeira, Miguel C.; Alasoo, Kaur; Guerreiro, Joana F.; Sa-Correia, Isabel. "Yeast response and tolerance to benzoic acid involves the Gcn4-and Stp1-regulated multidrug/multixenobiotic resistance transporter Tpo1". Applied Microbiology and Biotechnology 101 12 (2017): 5005-5018. 10.1007/s00253-017-8277-6 Cardoso, Joao M. S.; Guerreiro, Soraia I.; Lourenco, Andreia; Alves, Marta M.; Fatima Montemor, M.; Mira, Nuno P.; Leitao, Jorge H.; Carvalho, M. Fernanda N. N.. "Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus". Plos One 12 5 (2017): 10.1371/journal.pone.0177355 Salazar, Sara Barbosa; Wang, Can; Musterkotter, Martin; Okamoto, Michiyo; Takahashi-Nakaguchi, Azusa; Chibana, Hiroji; Lopes, Maria Manuel; et al. "Comparative genomic and transcriptomic analyses unveil novel features of azole resistance and adaptation to the human host in Candida glabrata.". FEMS yeast research (2017): 10.1093/femsyr/fox079 Henriques, Slvia F.; Mira, Nuno P.; Sa-Correia, Isabel. "Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants". Biotechnology For Biofuels 10 (2017): 10.1186/s13068-017-0781-5 Guerreiro, Joana F.; Mira, Nuno P.; Santos, Aline X. S.; Riezman, Howard; Sa-Correia, Isabel. "Membrane Phosphoproteomics of Yeast Early Response to Acetic Acid: Role of Hrk1 Kinase and Lipid Biosynthetic Pathways, in Particular Sphingolipids". Frontiers in Microbiology 8 (2017): 10.3389/fmicb.2017.01302 Cunha, Diana V.; Salazar, Sara B.; Lopes, Maria M.; Mira, Nuno P.. "Mechanistic Insights Underlying Tolerance to Acetic Acid Stress in Vaginal Candida glabrata Clinical Isolates". Frontiers in Microbiology 8 (2017): 10.3389/fmicb.2017.00259 Seixas, Isabel; Barbosa, Catarina; Salazar, Sara B; Mendes-Faia, Arlete; Wang, Yu; Guldener, Ulrich; Mendes-Ferreira, Ana; Mira, Nuno P. "Genome Sequence of the Nonconventional Wine Yeast Hanseniaspora guilliermondii UTAD222.". Genome announcements 5 5 (2017): 10.1128/genomeA.01515-16 Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, Leonel; Silva, Sonia; Salazar, Sara B.; Schroder, Markus S.; et al. "The CgHaa1-Regulon Mediates Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata". G3-Genes Genomes Genetics 7 1 (2017): 1-18. 10.1534/g3.116.034660 Alves, Marta M.; Cunha, Diana V.; Santos, Catarina F.; Mira, Nuno P.; Montemor, Maria F.. "In vitro corrosion behaviour and anti-Candida spp. activity of Zn coated with ZnO-nanostructured 'Anastacia' flowers". Journal of Materials Chemistry B 4 27 (2016): 4754-4761. 10.1039/c6tb00797j Santos, Rui; Costa, Catarina; Mil-Homens, Dalila; Romao, Daniela; de Carvalho, Carla C C R; Pais, Pedro; Mira, Nuno P; Fialho, Arsenio M; Teixeira, Miguel C. "The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.". Cellular microbiology (2016): 10.1111/cmi.12686 Trcek, Janja; Mira, Nuno Pereira; Jarboe, Laura R.. "Adaptation and tolerance of bacteria against acetic acid". Applied Microbiology and Biotechnology 99 15 (2015): 6215-6229. 10.1007/s00253-015-6762-3 Mira, N. P.; Bernardo, R.; Cunha, D.; Wang, C. A. N.; JChibana, H. I. R. O.; Silva, S.; Sa-Correia, I.; Azeredo, J.; Butler, G.. "Genetic adaptive mechanisms mediating response and tolerance to acetic acid stress in the human pathogen Candida glabrata: role of the CgHaa1-dependent signaling pathway". Mycoses 58 (2015): 188-189. Mira, N. P.; Salazar, S.; Pedreira, T.; Wang, C. A. N.; Alves, S.; Henriques, R.; Sousa, M.; et al. "Comparative genomic and transcriptomic analysis unveil novel features of antifungal resistance in the human pathogen Candida glabrata". Mycoses 58 (2015): 72-72. Palma, Margarida; Roque, Filipa de Canaveira; Guerreiro, Joana Fernandes; Mira, Nuno Pereira; Queiroz, Lise; Sa-Correia, Isabel. "Search for genes responsible for the remarkably high acetic acid tolerance of a Zygosaccharomyces bailii-derived interspecies hybrid strain". Bmc Genomics 16 (2015): 10.1186/s12864-015-2278-6 Barbosa, Catarina; Mendes-Faia, Arlete; Lage, Patricia; Mira, Nuno P; Mendes-Ferreira, Ana. "Genomic expression program of Saccharomyces cerevisiae along a mixed-culture wine fermentation with Hanseniaspora guilliermondii.". Microbial cell factories 14 1 (2015): 124-124. 10.1186/s12934-015-0318-1 de-Carvalho, Jorge; Rodrigues, Rogerio M. M.; Tome, Brigitte; Henriques, Silvia F.; Mira, Nuno P.; Sa-Correia, Isabel; Ferreira, Guilherme N. M.. "Conformational and mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model". Analyst 139 8 (2014): 1847-1855. 10.1039/c3an01682j Costa, C.; Nunes, J.; Henriques, A.; Mira, N. P.; Nakayama, H.; Chibana, H.; Teixeira, M. C.. "Candida glabrata drug:H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis". J Antimicrob Chemother (2014): 10.1093/jac/dku044 Teixeira, Miguel Cacho; Monteiro, Pedro Tiago; Guerreiro, Joana Fernandes; Goncalves, Joana Pinho; Mira, Nuno Pereira; dos Santos, Sandra Costa; Cabrito, Tania Rodrigues; et al. "The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae". Nucleic Acids Research 42 D1 (2014): D161-D166. 10.1093/nar/gkt1015 Mira, N. P.; Münsterkötter, M.; Dias-Valada, F.; Santos, J.; Palma, M.; Roque, F. C.; Guerreiro, J. F.; et al. "The Genome Sequence of the Highly Acetic Acid-Tolerant Zygosaccharomyces bailii-Derived Interspecies Hybrid Strain ISA1307, Isolated From a Sparkling Wine Plant". DNA Res (2014): 10.1093/dnares/dst058 Mira, Nuno P.; Teixeira, Miguel C.. "Microbial mechanisms of tolerance to weak acid stress". Frontiers in Microbiology 4 (2013): 10.3389/fmicb.2013.00416 Mira, Nuno P; Teixeira, Miguel C; Sa-Correia, Isabel. "Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast: "in silico" and "wet-lab" approaches.". Methods in molecular biology (Clifton, N.J.) 809 (2012): 27-48. 10.1007/978-1-61779-376-9_2 Teixeira, Miguel C.; Godinho, Claudia P.; Cabrito, Tania R.; Mira, Nuno P.; Sa-Correia, Isabel. "Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation". Microbial Cell Factories 11 (2012): 10.1186/1475-2859-11-98 dos Santos, Sandra C.; Mira, Nuno P.; Moreira, Ana S.; Sa-Correia, Isabel. "Quantitative- and Phospho-Proteomic Analysis of the Yeast Response to the Tyrosine Kinase Inhibitor Imatinib to Pharmacoproteomics-Guided Drug Line Extension". Omics-a Journal of Integrative Biology 16 10 (2012): 537-551. 10.1089/omi.2012.0012 Guerreiro, Joana F.; Mira, Nuno P.; Sa-Correia, Isabel. "Adaptive response to acetic acid in the highly resistant yeast species Zygosaccharomyces bailii revealed by quantitative proteomics". Proteomics 12 14 (2012): 2303-2318. 10.1002/pmic.201100457 Teixeira, Miguel C.; Mira, Nuno P.; Sa-Correia, Isabel. "A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae". Current Opinion in Biotechnology 22 2 (2011): 150-156. 10.1016/j.copbio.2010.10.011 Mira, Nuno P.; Henriques, Silvia F.; Keller, Greg; Teixeira, Miguel C.; Matos, Rute G.; Arraiano, Cecilia M.; Winge, Dennis R.; Sa-Correia, Isabel. "Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress". Nucleic Acids Research 39 16 (2011): 6896-6907. 10.1093/nar/gkr228 Mira, Nuno P.; Madeira, Andreia; Moreira, Ana Silvia; Coutinho, Carla P.; Sa-Correia, Isabel. "Genomic Expression Analysis Reveals Strategies of Burkholderia cenocepacia to Adapt to Cystic Fibrosis Patients' Airways and Antimicrobial Therapy". Plos One 6 12 (2011): 10.1371/journal.pone.0028831 Coutinho, Carla P.; dos Santos, Sandra C.; Madeira, Andreia; Mira, Nuno P.; Moreira, Ana S.; Sa-Correia, Isabel. "Long-term colonization of the cystic fibrosis lung by Burkholderia cepacia complex bacteria: epidemiology, clonal variation, and genonne-wide expression alterations". Frontiers in Cellular and Infection Microbiology 1 (2011): 10.3389/fcimb.2011.00012 Pereira, Francisco B.; Guimaraes, Pedro M. R.; Gomes, Daniel G.; Mira, Nuno P.; Teixeira, Miguel C.; Sa-Correia, Isabel; Domingues, Lucilia. "Identification of candidate genes for yeast engineering to improve bioethanol production in very high gravity and lignocellulosic biomass industrial fermentations". Biotechnology For Biofuels 4 (2011): 10.1186/1754-6834-4-57 Abdulrehman, Dario; Monteiro, Pedro Tiago; Teixeira, Miguel Cacho; Mira, Nuno Pereira; Lourenco, Artur Bastos; dos Santos, Sandra Costa; Cabrito, Tania Rodrigues; et al. "YEASTRACT: providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface". Nucleic Acids Research 39 (2011): D136-D140. 10.1093/nar/gkq964 Goncalves, Joana P.; Francisco, Alexandre P.; Mira, Nuno P.; Teixeira, Miguel C.; Sa-Correia, Isabel; Oliveira, Arlindo L.; Madeira, Sara C.. "TFRank: network-based prioritization of regulatory associations underlying transcriptional responses". Bioinformatics 27 22 (2011): 3149-3157. 10.1093/bioinformatics/btr546 Dos Santos, S.C.; Teixeira, M.C.; Mira, N.P.; Cabrito, T.R.; Palma, M.; Lourenço, A.B.; Dias, P.J.; et al. "Response and resistance to drugs and chemical stress in the yeast model: A genome-wide view". 1st Portuguese Meeting in Biomedical Engineering, ENBENG 2011 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80053997032&partnerID=MN8TOARS. 10.1109/ENBENG.2011.6026076 Mira, Nuno P.; Palma, Margarida; Guerreiro, Joana F.; Sa-Correia, Isabel. "Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acid". Microbial Cell Factories 9 (2010): 10.1186/1475-2859-9-79 Mira, Nuno P.; Teixeira, Miguel Cacho; Sa-Correia, Isabel. "Adaptive Response and Tolerance to Weak Acids in Saccharomyces cerevisiae: A Genome-Wide View". Omics-a Journal of Integrative Biology 14 5 (2010): 525-540. 10.1089/omi.2010.0072 Mira, Nuno P.; Becker, Jorg D.; Sa-Correia, Isabel. "Genomic Expression Program Involving the Haa1p-Regulon in Saccharomyces cerevisiae Response to Acetic Acid". Omics-a Journal of Integrative Biology 14 5 (2010): 587-601. 10.1089/omi.2010.0048 Sa-Correia, Isabel; dos Santos, Sandra C.; Teixeira, Miguel C.; Cabrito, Tania R.; Mira, Nuno P.. "Drug:H+ antiporters in chemical stress response in yeast". Trends in Microbiology 17 1 (2009): 22-31. 10.1016/j.tim.2008.09.007 Mira, Nuno P.; Lourenco, Artur B.; Fernandes, Alexandra R.; Becker, Jorg D.; Sa-Correia, Isabel. "The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids". Fems Yeast Research 9 2 (2009): 202-216. 10.1111/j.1567-1364.2008.00473.x Teixeira, Miguel C.; Raposo, Luis R.; Mira, Nuno P.; Lourenco, Artur B.; Sa-Correia, Isabel. "Genome-Wide Identification of Saccharomyces cerevisiae Genes Required for Maximal Tolerance to Ethanol". Applied and Environmental Microbiology 75 18 (2009): 5761-5772. 10.1128/AEM.00845-09 Monteiro, P.T.; Mendes, N.D.; Teixeira, M.C.; D'orey, S.; Tenreiro, S.; Mira, N.P.; Pais, H.; et al. "YEASTRACT-DISCOVERER: New tools to improve the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae". Nucleic Acids Research 36 SUPPL. 1 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-38549135468&partnerID=MN8TOARS. 10.1093/nar/gkm976 Teixeira, MC; Fernandes, AR; Mira, NP; Becker, JD; Sa-Correia, I. "Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid". Fems Yeast Research 6 2 (2006): 230-248. 10.1111/j.1567-1364.2006.00041.x Teixeira, Miguel C.; Monteiro, Pedro; Jain, Pooja; Tenreiro, Sandra; Fernandes, Alexandra R.; Mira, Nuno P.; Alenquer, Marta; et al. "The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae". Nucleic Acids Research 34 (2006): D446-D451. 10.1093/nar/gkj013 Simoes, T.; Mira, N. P.; Fernandes, A. R.; Sa-Correia, Isabel. "The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservatives". Applied and Environmental Microbiology 72 11 (2006): 7168-7175. 10.1128/AEM.01476-06 Fernandes, AR; Mira, NP; Vargas, RC; Canelhas, I; Sa-Correia, I. "Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes". Biochemical and Biophysical Research Communications 337 1 (2005): 95-103. 10.1016/j.bbrc.2005.09.010

Other

Annotation

Isabel Sá-Correia; Mira, Nuno Pereira; Martin Münsterkötter; Dias-Valada, Filipa; Júlia Santos ; Margarida Palma; Filipa C Roque ; et al. 2014. "The genome sequence and annotation of the highly acetic acid-tolerant Zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant ,The sequence and annotation of the genome of the ISA1307 strain disclosed in this study are accessible at http://pedant.helmholtz-muenchen.de/genomes.jsp?Category=fungal, including browsing by a GBrowse instance".

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021/11	Comparative genomics unveils fundamental traits on the biology and physiology of species of the Saccharomycodeacea family	MicroBiotec21
2021/11	The COST Action EuroMicropH: Understanding and exploiting the impacts of low pH on microrganisms	MicroBiotec21
2021/08	Comparative genomics unveils fundamental traits on the biology and physiology of bio-flavouring species of the Saccharomycodeacea family	International Conference on Yeasts
2019	Study of the interaction between lactobacilli, Candida albicans and Candida glabrata: from physiological aspects to OMICs analyses	46th Annual Conference on Yeasts (Slovakia)
2019	Towards the development of new antifungal therapies based on non-conventional targets	Encontro Nacional Ciência 2019 (Portugal)
2019	Study of the interaction between lactobacilli, Candida albicans and Candida glabrata: from physiological aspects to OMICs analyses	7th Physiology of Yeasts and Filamentous Fungi (Italy)
2019	Study of the interaction between vaginal lactobacilli, Candida albicans and Candida glabrata: from physiological aspects to OMICs analyses	XXX Fungal Genetics Conference (United States)
2018	Comparative genomic and transcriptomic analysis unveil novel features of antifungal resistance and adaptation to the human host in Candida glabrata	Microbial Stress Meeting (Ireland)
2017	Genetic adaptive mechanisms Genetic Adaptive Mechanisms Mediating Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata: Role of the CgHaa1-dependent Signaling Pathway	YEAST2017 – XXVII International Conference on Yeast Genetics and Molecular Biology (Czech Republic)
2015	Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to itaconic acid	Microbial Stress: From molecules to biosystems (Spain)
2015	Genetic adaptive mechanisms mediating response and tolerance to acetic acid stress in the human pathogen Candida glabrata: role of the CgHaa1-dependent signaling pathway	32nd International Specialized Symposium in Yeasts (Italy)
2015	Genetic adaptive mechanisms mediating response and tolerance to acetic acid stress in the human pathogen Candida glabrata: role of the CgHaa1-dependent signaling pathway	Jornadas Portuguesas de Genética (Portugal)
2014	Genome sequence and annotation of the highly acetic acid-tolerant Zygosaccharomyces bailii derived interspecies hybrid strain ISA1307	XX Jornadas Biologia de Leveduras Prof Nicolau van Uden (Portugal)
2013	Genome sequence and annotation of the highly acetic acid-tolerant Zygosaccharomyces bailii derived interspecies hybrid strain ISA1307	MicroBiotec (Portugal)
2011	Response and Resistance to Drugs and Chemical Stress in the Yeast Model: a Genome- Wide View	1st National Meeting on Bioengineering (Portugal)
2011	Haa1p-dependent regulatory network of the yeast response to acetic acid stress	Microbiotec 11 (Portugal)
2010	Adaptive response and tolerance to acetic acid stress in yeast: a genome-wide view	2nd Meeting of the Institute for Biotechnology and Bioengineering (Portugal)
2010	Gene expression regulation mediated by the acetic acid-responsive yeast transcription factor Haa1p: DNA binding site and role of copper in DNA binding	XVIII Jornadas de Biologia de Leveduras Professor Nicolau van Uden (Portugal)
2009	Global analysis of yeast determinants of resistance to ethanol: the important role of FPS1	MicroBiotec 2009
2009	Adaptation and resistance to acetic acid in S. cerevisiae mediated by the Haa1p-regulon	XXV Yeast Genetics and Molecular Biology (United Kingdom)
2009	Adaptation and resistance to acetic acid in S. cerevisiae mediated by the Haa1p-regulon	XVII Jornadas de Leveduras Professor Nicolau van Uden
2009	Genome-wide requirements for maximal tolerance to ethanol and weak organic acids	1st scientific meeting of the Institute for Biotechnology and Bioengineering (Portugal)
2007	Adaptive response and resistance to acetic and propionic acids: involvement of Haa1p- and Rim101p-dependent regulons	Physiology of yeasts and filamentous Fungi (PYFF3) (Finland)
2007	The RIM101 pathway is involved in Saccharomyces cerevisiae resistance to propionic acid	MicroBiotec 2007 (Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/02 - Current	Investigating molecular mechanisms of underneath the interference between clinical strains of L. gasseri and Candida species Supervisor of Margarida Nunes Duarte	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/10 - Current	Towards the reduction of sulfite-based preservation in wines: from molecular approaches to applied solutions Supervisor of Bárbara Barros Coelho	Doutoramento em Biotecnologia e Biociências (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/10 - Current	Synthetic biology approaches to enable microbe-based production of new-to-nature carboxylic acids Supervisor of José Pedro Cerqueira Bento	Mestrado em Biotecnologia (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/04 - Current	Unveiling CgPdr1-dependent and -independent mechanisms of resistance to azoles in the pathogenic yeast Candida glabrata Supervisor of Maria Joana Faustino Pinheiro	Biotechnology and Biosciences (PhD)
2020 - Current	Fostering the use of non-Saccharomyces yeast strains as starter-cultures and biocontrol agents in wine industry Co-supervisor of Marcos Josué da Costa Esteves	PhD in Biology (PhD) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2018 - Current	Harnessing the power of wine Non-Saccharomyces yeasts for tailored fermented beverages through genomic analysis Supervisor of Maria João Alves Tavares	PhD in Biotechnology and Biosciences (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2032/12	Towards the development of industrially friendly Hanseniaspora strains Supervisor of Diogo Alexandre Gomes dos Santos	Masters in Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02 - 2023/12	Exploring the potential of recombined mellitin as a putative anti-Candida agent Co-supervisor of Ana Luísa Louro de Oliveira	Mestrado em Engenharia Biológica (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/10 - 2023/11	Understanding the acqusition of antifungal resistance across pathogenic non-albicans Candida species Supervisor of Carolina Soares Bastos de Sousa	Mestrado em Microbiologia (Master)
2022/09 - 2023/11	Fostering the development of live anti-Candida parmaceuticals based on the probiotic species Lactobacillus gasseri Supervisor of Gabriela Almeida Fontebasso	Mestrado em Microbiologia (Master)
2018 - 2023/11	Dissecting the molecular mechanisms underneath the interaction between human colonizing Lactobacillus and the pathogenic yeasts C. glabrata and C. albicans Supervisor of Nuno Aparício Pedro	PhD in Biotechnology and Biosciences (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/06 - 2023/07	Fostering the study of purification and anti-Candida properties of Portuguese Apis mellifera apitoxin Co-supervisor of Carolina Martins Glória	Mestrado em Engenharia Biológica (Master)
2021/09 - 2022/12	Investigating mechanisms of adaptation to the wine preservative SO2 as a mean to foster the development of "greener" preservation strategies Supervisor of Bárbara Barros Coelho	Masters in Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2022/11	A physiological portrait of the non-conventional wine yeast Hanseniaspora guilliermondii guided by genomic analyses Co-supervisor	Molecular and Comparative Genetics (PhD) Universidade de Trás-os-Montes e Alto Douro Centro de Estudos em Letras, Portugal
2017 - 2022/06	Role of the CgHaa1 and CgPdr1-dependent systems in C. glabrata response and tolerance to stress Supervisor of Sara Barbosa Salazar	PhD in Biotechnology and Biosciences (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 - 2021	Phenotypic analysis, genome sequencing and annotation of the non-conventional wine yeast Saturnispora diversa Supervisor of Sebastião Pardal da Silva	Masters in Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2021	Synthetic biology approaches to foster Yeasts as hosts for the production of carboxylic acids and their derivatives: emphasis on levulinic and itaconic acids Supervisor	PhD in Bioengineering (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2020	Optimization of Yeast-based molecular biosensors for the detection of itaconic acid and sulfur dioxide Supervisor of Leonor Martins Pereira	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2020	Towards the rational use of Non-Saccharomyces Yeasts and their encoded ß-glucosidase enzymes in modulation of primary wine aroma Supervisor of João Pedro Narciso Silva	Master in Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2019	Epidemiological survey of the pattern of colonization and infection caused by species of the Candida genus in Hospitals of the Lisbon area: emphasis on azole resistance and emergence of non-conventional species Supervisor of Catarina Alves Mendonça	Pharmaceutical Sciences (Master) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019	Developing novel anti-Candida therapies through the understanding of drug-resistance mechanisms and by tailoring new chemicals to be used in anti-biofilm surfaces Supervisor of Maria Joana Faustino Pinheiro	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019	Synthetic biology approaches to implement microbe-based production of economically relevant itaconic acid derivatives Supervisor of Fernão Castanheira Mendes	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019	Physiological studies of co-cultivating Candida albicans or Candida glabrata in the presence of Lactobacillus gasserii or Lactobacillus reuterii Supervisor of Catarina Daniela Alves Lima	Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019	Towards implementation of an itaconic acid biosensor for prospecting eukaryotic host producers Supervisor of Inês Oliveira Fonseca	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2019	Tracking the genes and pathways involved in S. cerevisiae response and tolerance to the wine preservatives SO2 and chitosan: from molecular analyses to OMICS approaches Co-supervisor	PhD in Molecular and Comparative Genetics (PhD) Universidade de Trás-os-Montes e Alto Douro, Portugal
2017 - 2018	Process, transport and metabolic engineering to improve yeast-based production of add-value carboxylic acids Supervisor	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018	A contribution to further understand the molecular mechanisms of antifungal resistance in Candida glabrata mediated by the transcription factor CgPdr1 Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018	Exploring non-conventional Yeasts as cell factories for the production of add-value organic acids: focus on Candida ethanolica Supervisor	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018	Identification of DNA motifs with potential relevance in regulation of gene expression in Yeast using Information Theory Supervisor	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018	Strategies to improve yeast-based production of itaconic acid: focus on mitochondrial to cytosol transport Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017	Study of the interaction between vaginal lactobacilii, Candida albicans and Candida glabrata: from physiological aspects to transcriptomic analyses Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017	Comparative genomics of Saccharomyces cerevisiae wine strains to unveil new genes involved in the stressful environment of wine musts Supervisor	Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017	Exploring the non-conventional yeast Itssachenkia orientalis as a cell factory for the production of itaconic acid Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017	Unveiling new gain-of-function mutants in CgPdr1 transcription factor mediating azole resistance in Candida glabrata Supervisor	Applied Microbiology (Master) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2015 - 2016	Exploring the interference between Lactobacilii and Candida spp. to foster the development of non-conventional antifungal therapies Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2016	Exploring genetic and metabolic engineering strategies to implement yeast-based production of itaconic acid Supervisor	Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2015	Effect of alterations in non-coding regions in genomic expression reprogramming of two Candida glabrata clinical isolates Supervisor	Microbiology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2015	Towards the identification of biomarker genes for the early diagnosis of invasive candidemia caused by Candida glabrata Supervisor	Biological Engineering (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2015	Metabolic engineering strategies to improve yeast-based production of itaconic acid guided by in silico metabolic modelling Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2014	Genomic analysis of a Candida glabrata clinical isolate resistant to antifungal unveils novel features of drug resistance in this pathogenic yeast Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2014	Exploring Saccharomyces cerevisiae to improve microbe-based production of itaconic acid Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2014	Molecular mechanisms underlying tolerance to acetic acid in vaginal Candida glabrata clinical isolates: role of the CgHaa1-signalling system Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2013	Towards the production of levulinic and itaconic acids in Saccharomyces cerevisiae: a contribution for the understanding of toxicity of these acids in producing cells Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2013	Functional analysis of the Candida glabrata CgHaa1 (ORF CAGL0L09339g) transcription factor Supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 - 2010	The Yeast transcription factor Haa1p: identification of amino acid residues essential for functional Haa1-DNA associations Co-supervisor	Biotechnology (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2008	Expression and purification of the S. cerevisiae Haa1p transcription factor in E. coli and identification of critical residues in Haa1p activity Co-supervisor	Biochemistry (Master) Universidade de Coimbra, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2016 - Current	Member of the organizing committee of the 6th meeting on the physiology of yeasts and filamentous Fungi (PYFF) that took place in Lisbon, at Instituto Superior Técnico, from 11-14 July 2016, Lisbon, Portugal (2016) Conference (Member of the Organising Committee)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - Current	Member of the organizing committee of the XX Jornadas de Biologia de Leveduras Prof Nicolau van Uden, that took place in Lisbon, at Instituto Superior Técnico, from 10-11 July 2014, Lisbon, Portugal (2014) Conference (Member of the Organising Committee)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02 - 2020/02	Chaired the 1st Open Meeting of the COST Action EuroMicropH (https://euromicroph.eu) that took place in Lisbon, at Instituto Superior Técnico, from Feb 12 till Feb 14, 2020 (2020) Conference (President of the Organising Committee)	Universidade de Lisboa Instituto Superior Técnico, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019	Mathematical modelling of the impacts of environment using metabolic networks and game theory, (Thesis) Arguer	Taneli Henri Pusa (PhD) Université de Lyon, France
2019	Unveiling the complex regulatory network governing antifungal drug resistance in Candida glabrata: from new regulators to new effectors (Thesis) Arguer	Pedro Henrique Magalhães Fernandes (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Candida glabrata biofilms: mechanisms of antifungal resistance and matrix role (Thesis) Main arguer	Célia Fortuna Rodrigues (PhD) Universidade do Minho, Portugal
2018	Transcriptional responses of stress responses in the human pathogen Candida glabrata (Thesis) Main arguer	Antonin Thiébaut (PhD) Chancellerie des Universités de Paris La Sorbonne, France
2018	Efeito antimicrobiano/antibiofilme de nanopartículas de prata obtidas por uma síntese ‘green’ associadas ou não ao glicerofosfato de cálcio contra patógenos orais (Thesis) Main arguer	José António Santos Souza (PhD) Universidade Estadual Paulista Júlio de Mesquita Filho, Brazil
2017	Towards the improvement of tolerance to acetic and formic acids in yeast: identification of candidate genes and engineering of the Haa1 transcription factor (Thesis) Arguer	Sílvia Catarina Filipe Henriques (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016	Mechanistic insights into adaptation and tolerance to acetic acid in Saccharomyces cerevisiae and Zygosaccharomyces bailii (Thesis) Arguer	Joana Filipa Guerreiro (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015	Liposomes as antigenic delivery systems: development of an immunoprotective strategy against Candida albicans, PhD in Molecular and Environmental Biology (Thesis) Arguer	Maria Catarina Santos Carneiro (PhD) Universidade do Minho, Portugal
2014	Towards the understanding of the impact of nitrogen on wine fermentation: from classical to genomic approaches (Thesis) Main arguer	Catarina da Costa Rodrigues Barbosa (PhD) Universidade de Trás-os-Montes e Alto Douro, Portugal
2014	Antifungal drug resistance in the pathogenic yeast Candida glabrata: emphasis on the role of uncharacterized drug:H+ antiporters (Thesis) Arguer	Ana Catarina da Silva Portinho e Costa (PhD) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014	Clinical Candida species co-infection and associated virulence (Thesis) Main arguer	Carlos Tiago Lopes Alves (PhD) Universidade do Minho, Portugal

Conference scientific committee

	Conference name	Conference host
2015 - Current	Microbial Stress Meeting: From Systems to Molecules and Back
2013 - Current	Microbial Stress Meeting: From Systems to Molecules and Back

Distinctions

Award

2013	Gilead Genese Program Gilead , Portugal

Other distinction

2020	Award for excellence in pedagogical activity Universidade de Lisboa Instituto Superior Técnico, Portugal
2019	Award for excellence in pedagogical activity Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Award for excellence in pedagogical activity Universidade de Lisboa Instituto Superior Técnico, Portugal
2013	Best communication award (ex-aqueo) at the National Meeting of Microbiology and Biotechnology MicroBiotec 2013
2011	Honorable Mention as a Young Researcher in the field of Biochemistry and Biological Engineering
2003	Bolsa de Mérito Universidade de Lisboa Instituto Superior Técnico, Portugal