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Presently, Ana Reis-Mendes (A.R-M) is currently a Postdoctoral researcher at the associated laboratory LAQV/REQUIMTE at the Faculty of Pharmacy of the University of Porto (FFUP). A.R-M obtained her PhD in Pharmaceutical Sciences, with a specialization in Toxicology, from the FFUP (2024). She also holds a Master's degree in Analytical, Clinical, and Forensic Toxicology from the same institution (2014) and a Bachelor's degree in Biochemistry (2012) from the Faculty of Sciences of the University of Porto. Currently, A.R-M is a Postdoctoral researcher in the project "Novel tools for exposure assessment of food contaminants through saliva multiple biomarker monitoring," funded by the Portuguese Foundation for Science and Technology (FCT) (2022.08978.PTDC) at LAQV-REQUIMTE (Network of Chemistry and Technology), in the Bromatology and Hydrology Laboratory, Department of Chemistry, FFUP. During her PhD, A.R-M developed the thesis entitled "Inflammation and disruption of redox homeostasis (but not metabolism) significantly contribute to the cardiotoxic effects of mitoxantrone and doxorubicin: findings from in vitro and in vivo studies conducted on differently aged mice," as part of the FCT-funded projects (SFRH/BD/129359/2017 and COVID/BD/152374/2022), at UCIBIO-REQUIMTE (Network of Chemistry and Technology) - Toxicology Laboratory, Department of Biological Sciences, FFUP. A.R-M. has participated in the organization of 2 scientific events, being one international. A.R-M has published 23 papers in international peer-reviewed journals (18 in the last five years), 10 of which as the first author, and contributed 23 abstracts in international journals, one database, and 49 poster/oral presentations at national conferences and 34 at international conferences, earning five awards. My research impact demonstrated through collaboration with 60 scientists, is reflected in my high citation metrics (total h-index = 8, 173 citations; last five years h-index = 7, 115 citations, Scopus). A.R-M is currently guest editor of a special issue for the "Pharmaceutics" (MDPI) titled "Advances in Anticancer Drug Metabolism: Implications for Personalized Therapeutics (https://www.mdpi.com/journal/pharmaceutics/special_issues/5P7P1GA7ZP).
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Identification

Personal identification

Full name
Ana Filipa Reis Mendes

Citation names

  • Reis-Mendes, Ana
  • Reis-Mendes, Ana Filipa
  • Reis-Mendes, A.

Author identifiers

Ciência ID
0E17-0F19-79B9
ORCID iD
0000-0002-2775-3147
Researcher Id
T-3712-2017
Scopus Author Id
57050347000

Email addresses

  • afreis.mendes@gmail.com (Professional)
  • amendes@ff.up.pt (Professional)

Telephones

Telephone
  • 220428641 (Professional)

Addresses

  • LAQV/REQUIMTE - Laboratory of Bromatology and Hidrology, Faculty of Pharmacy, University of Porto Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Exact Sciences - Chemical Sciences - Analytical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2018/02/01 - 2024/04/11
Concluded
 PhD in Pharmaceutical Sciences - Specialty in Toxicology (Doutoramento)
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
"‘Inflammation and disruption of redox homeostasis (but not metabolism) significantly contribute to the cardiotoxic effects of mitoxantrone and doxorubicin: findings from in vitro and in vivo studies conducted on differently aged mice’" (THESIS/DISSERTATION)
2020/09/17 - 2021/06/23
Concluded
 English course B2.1 (Outros)
Major in English
Lancaster College - Instituto de Línguas , Portugal
 88% out of 100%
2019/09/18 - 2020/06/16
Concluded
 English course B1.1 (Outros)
Major in English
Lancaster College - Instituto de Línguas , Portugal
 89% out of 100%
2018/10/08 - 2018/10/12
Concluded
 Practical Course in Laboratory Animal Sciences - Category B (according to FELASA recommendations) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboartório, Portugal
19
2018/10/08 - 2018/10/12
Concluded
 Theoretical Course in Laboratory Animal Science - Category B (according to FELASA recommendations) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboartório, Portugal
17
2017/02/01 - 2018/06/01
Concluded
 PhD course in Pharmaceutical Sciences (Curso de doutoramento (conclusão de unidades curriculares))
Major in Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
 18
2017/05/08 - 2017/05/14
Concluded
 Course on Cardiopulmonary toxicity (Outros)
Univerzita Karlova Lékarská fakulta v Hradci Králové, Czech Republic
2012/09/03 - 2014/11/14
Concluded
 Master in Analytical, Clinical and Forensic Toxicology (Mestrado)
Major in Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
"The synthesis and in vitro toxicological evaluation of the mitoxantrone naphthoquinoxaline metabolite: a comparative study with the parent drug" (THESIS/DISSERTATION)
 16
2009/09/07 - 2012/09/04
Concluded
 Degree in Biochemistry (Licenciatura)
Universidade do Porto Departamento de Química e Bioquímica, Portugal
"Apo E e Doença de Behçet" (THESIS/DISSERTATION)
 13
2007/09/04 - 2008/06/27
Concluded
 Technological Specialization Course (CET) Level IV - Specialization in Microbiology (Curso de Especialização Tecnológica)
Major in Microbologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 15
2006/09/04 - 2007/09/03
Concluded
 Laboratory Technician Course - Microbiology - Level IV (Curso Técnico Superior Profissional)
Major in Microbiologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2023/11/02 - Current Researcher (Research) REQUIMTE/Department of Chemical Sciences, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2018/02/01 - 2023/07/15 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2017/01/16 - 2018/02/01 Researcher (Research) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2016/02/12 - 2017/01/15 Researcher (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2013/07 - 2015/09 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2011/11 - 2012/09 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Departamento de Química e Bioquímica, Portugal
(...)
2011/03/01 - 2011/07/26 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
REQUIMTE LAQV Porto, Portugal
2007/11/12 - 2008/02/12 Research Trainee (Research) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2011/10 - 2016/02 Management and waitress Restaurante 3M, Lda, Portugal
Restaurante 3M, Lda, Portugal
2008/10/01 - 2009/10/30 Laboratory Technician Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
2008/03/11 - 2008/09/30 Traineeship as Laboratory Technician Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Grant

Designation Funders
2024/01/01 - Current SALIVA+ - Novel tools for exposure assessment of food contaminants by saliva multiple biomarker monitoring
2022.08978.PTDC
Research Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/02/01 - 2023/07/15 Inflammation and redox homeostasis disruption (but not metabolism) are major contributors to the cardiotoxicity of mitoxantrone and doxorubicin: in vitro and in vivo studies on differently aged mice
SFRH/BD/129359/2017
COVID/BD/152374/2022
PhD Student Fellow
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/02 - 2017/01/15 Apoio a laboratórios da Escola de Ciências, designadamente Gestão dos Espaços e Equipamentos Laboratoriais, Aquisição de Bens e Serviços, Controlo de Stocks, Gestão de Conteúdos de Portais Web, Gestão de Coleções Biológicas, Higiene e Segurança de Laboratórios
UID/BIA/04050
POCI-01-0145-FEDER-007569
Research Technician Fellow
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/16 - 2018/02/01 Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?
PTDC/DTP-FTO/1489/2014
Research Fellow
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Desporto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/09/01 - 2014/10/31 Why is mitoxantrone a poison to the heart? Focus on mitochondria, cytoskeleton, and metabolic bioactivation mechanisms
EXPL/DTP-FTO/0290/2012
Other
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Desporto, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Ana Dias-Carvalho; Ana Margarida-Araújo; Reis-Mendes, Ana; Catarina Oliveira Sequeira; Sofia Azeredo Pereira; Paula Guedes de Pinho; Félix Carvalho; et al. "Mitoxantrone disrupts brain glutathione defence and the metabolic pathways in CD-1 mice". Paper presented in Toxicology Letters, 2024.
    Published
  2. Viegas, Olga; Martins, Zita; Reis-Mendes, Ana; Araújo, Ana Margarida; Borges, Cristiane B.; Silva, Marta; Faria, Miguel A; Ferreira, Isabel M.P.L.V.O. "Biomonitoring the exposure to diet contaminants through saliva". Paper presented in 22nd Abstract Book Of the 22nd World Congress of Food Science and Technology (IUFOST 2024), 2024.
    Published
  3. Sofia Reis Brandão; Reis-Mendes, Ana; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Cardiac mitochondrial dynamics, autophagy, and regeneration are stirred by doxorubicin in old CD-1 mice". Paper presented in Scientific Letters, 2023.
    Published • 10.48797/sl.2023.54
  4. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Molecular alterations underlying doxorubicin’s chronic cardiotoxicity in a mouse model". Paper presented in RevSALUS, 2022.
    Published
  5. Ana Dias-Carvalho; Mariana Ferreira; Ana Reis-Mendes; Rita Ferreira; Eduarda Fernandes; Susana Isabel Sá; João Paulo Capela; Félix Carvalho; Vera Marisa Costa. "Unveiling the neurotoxicity of mitoxantrone: oxidative stress, apoptosis, and autophagy in the brain of adult CD-1 mice". Paper presented in Proceeding of 8th International Electronic Conference on Medicinal Chemistry, 2022.
    Published
  6. Ana Dias-Carvalho; Mariana Ferreira; Reis-Mendes, Ana; Rita Ferreira; Eduarda Fernandes; Susana Isabel Sá; João Paulo Capela; Félix Carvalho; Vera Marisa Costa. "Mitoxantrone-induced neurotoxicity in CD-1 mice". Paper presented in II International Congress of ToxRun and V Congress of the Portuguese Association of Forensic Sciences, 2022.
    Published
  7. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte-Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Mitoxantrone disrupts cardiac metabolism along with proteolysis and regeneration in aged mice". Paper presented in Proceeding of 8th International Electronic Conference on Medicinal Chemistry, 2022.
    Published • 10.3390/ECMC2022-13173
  8. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Neuparth, Maria João; Bastos, Maria de Lourdes; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "The influence of the anticancer drugs doxorubicin and mitoxantrone on cardiac metabolism and autophagy". Paper presented in Toxicology Letters, 2021.
    Published
  9. Reis-Mendes, Ana; Ana Isabel Padrão; Margarida Duarte-Araújo; José Alberto Duarte; Salomé Gonçalves-Monteiro; Fernando Remião; Félix Carvalho; et al. Corresponding author: Reis-Mendes, Ana. "Involvement of inflammation in DOX-induced cardiotoxicity: an in vivo study". Paper presented in Toxicology Letters, 2021.
    Published
  10. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana I; Capela, João Paulo; Costa, Vera Marisa. "Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study". 2019.
  11. Brandão, Sofia; Reis-Mendes, Ana; Carvalho, Félix; Bastos, Maria; Ferreira, Rita; Costa, Vera. "Disclosing the effect of doxorubicin and mitoxantrone on cardiac mitochondrial proteome: an in vivo approach using a murine model". 2019.
    10.3390/ecmc2019-06350
  12. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". 2019.
    Published • 10.1016/j.toxlet.2019.09.002
  13. Brandão, Sofia; Reis-Mendes, A.; Carvalho, Félix; Bastos, Maria de Lourdes; Ferreira, Rita; Costa, Vera Marisa. "Exploring the effect of anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial plasticity using a proteomic approach". 2019.
    Published
  14. Reis-Mendes, A.; Duarte-Araújo, M.; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Maria de Lourdes Bastos; Emilia Sousa; Costa, Vera Marisa. "Mitoxantrone-induced toxicity in different age male CD-1 mice". 2019.
    Published • 10.1111/eci.13109
  15. Reis-Mendes, A.; Duarte-Araújo, M.; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Maria de Lourdes Bastos; Emilia Sousa; Costa, Vera. "Evaluation of the toxicity induced by doxorubicin in different age male CD-1 mice". 2019.
    Published
  16. Reis-Mendes, Ana; Duarte-Araújo, Margarida; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Remião, Fernando; Carvalho, Félix; Sousa, Emília; Bastos, Maria Lourdes; Costa, Vera Marisa. "Anticancer drugs-induced toxicity in different age male CD-1 mice". 2019.
    10.3390/ecmc2019-06365
  17. Dias-Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, A.; Duarte-Araújo, MargaridaGuedes, Rita; Rita Guedes; Gonçalves-Monteiro, Salomé; Carvalho, Félix; et al. "In vivo chemobrain study: the effects of doxorubicin and mitoxantrone in the brain of differently aged mice". Paper presented in Porto Biomed. J., 2019.
    Published
  18. Dias-Carvalho, Ana; Reis-Mendes, A.; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos ML; Sá, SI; Capela JP; Costa VM. "Chemobrain study: differential effects of doxorubicin and mitoxantrone in the brain of CD-1 mice". Paper presented in 1st International Electronic Conference on Brain Sciences., 2019.
    10.1097/j.pbj.0000000000000054
  19. Ana Dias-Carvalho; Reis-Mendes, Ana; Margarida Duarte-Araújo; Félix Carvalho; Maria Lourdes Bastos; Susana Isabel Sá; João Paulo Capela; Vera Marisa Costa. "Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ‘chemobrain’ study on clinically relevant doses". Paper presented in Porto Biomed. J., 2019.
    Published
  20. Reis-Mendes, Ana; Félix Carvalho; Emília Sousa; Fernando Remião; Maria Lourdes Bastos; Vera Marisa Costa. "Cardiotoxicity of FAC (5-fluorouracil + adriamycin + cyclophosphamide) metabolites in H9c2 cardiac differentiated cells". Paper presented in Toxicology Letters, 2018.
    Published
  21. Hrynchak, Ivanna; Reis-Mendes, A.; Palmeira, A; Bastos, M.L; Costa, Vera M. "Old Pharmaceuticals with New Applications: the Case Studies of Lucanthone and Mitoxantrone.". 2017.
    10.3390/ecmc-3-04663
  22. Reis-Mendes, A.; Gomes, A.S.; Carvalho, R.A.; Remião, F.; Carvalho, F.; Pinto, M.; Bastos, M.L.; Sousa, E.; Costa, V.M.. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". 2015.
    10.1016/j.toxlet.2015.08.882
  23. Reis-Mendes, Ana; Sousa, Emília; Remião, Fernando; Carvalho, Félix; Bastos, Maria Lourdes; Costa, Vera Marisa. "At pharmacology relevant concentrations, mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells with autophagy involvement". 2014.
Conference poster
  1. Dias-Carvalho, Ana; Araújo, Ana Margarida; Reis-Mendes, A.; Sequeira, CO; Pereira, AS; Guedes de Pinho, Paula; Carvalho, Félix; et al. "Chemobrain: exploring the impacto f a clinically relevant dose of mitoxantrone in the metabolic profile of CD-1 mice brain". Paper presented in EMBO Young Scientists Forum (Lisbon), 2023.
  2. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Reis-Mendes, Ana; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Application of 2-Azanorbornane for the Assembly of Bioactive Peptidomimetics". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, 2023.
  3. Ana Dias-Carvalho; Ana Reis-MendesAna Reis-Mendes; Eduarda Fernandes; Susana Isabel Sá; Félix Carvalho; Vera Marisa Costa. "A clinically relevant cumulative dose of doxorubicin in CD-1 male mice induces a long-term increase in hippocampal p53 levels". Paper presented in MitoPorto Mitochondrial physiology, redox biology, and genetics International Meeting, 2023.
  4. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Hugo Rocha; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Cardiac metabolic adaptation after doxorubicin and mitoxantrone on adult mice". Paper presented in 1st Conference of the Doctoral Program Metabolism – Clinical and Experimental, The prism of Diabesity: looking by a different perspective, 2022.
  5. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte-Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Mitoxantrone disrupts cardiac metabolism along with proteolysis and regeneration in aged mice". Paper presented in 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022), 2022.
  6. Mariana Ferreira; Ana Dias-Carvalho; Reis-Mendes, Ana; Rita Ferreira; Eduarda Fernandes; Susana Isabel Sá; João Paulo Capela; Félix Carvalho; Vera Marisa Costa. "The mitoxantrone neurotoxicity evaluated in CD-1 mice: a focus on cell death, redox homeostasis and astrogliosis". Paper presented in 15th Youth Researchers Meeting for students of Porto University (IJUP2022), 2022.
  7. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Unveiling the chronic cardiotoxic effects of doxorubicin on cardiac remodeling using a mouse model". Paper presented in Ciência 2022 – Science and Tecnology in Portugal Summit; Fundação para a ciência e a Tecnologia (FCT) & Ciência Viva, Lisbon Congress Centre, 2022.
  8. Baltazar, Telmo; Moreira-Pais, Alexandra; Reis-Mendes, Ana; Costa, Vera M.; Ferreira, Rita. "Impact of doxorubicin on skeletal muscle oxidative stress in elderly animals". Paper presented in XIII Biochemistry Day, 2022.
  9. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Ferreira, Rita; Fernandes, Eduarda; Sá, Susana I; Sá SI; Capela, João Paulo; Carvalho, Félix; Costa, Vera Marisa. "Evaluation of mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in 13th AIMS Meeting, 2022.
  10. Reis-Mendes, A.; Padrão, A.I.; Duarte-Araújo, M; Duarte, JA; Gonçalves-Monteiro, Salomé; Remião, Fernando; Carvalho, Félix; et al. "Involvement of inflammation in DOX-induced cardiotoxicity: an in vivo study". Paper presented in 56th Congress of the European Societies of Toxicology - Eurotox 2021, 2021.
  11. Reis-Mendes, A.; Ana Isabel Padrão; José Alberto Duarte; Vítor Seabra; Salomé Gonçalves-Monteiro; Margarida Duarte-Araújo; Fernando Remião; et al. Corresponding author: Reis-Mendes, A.. "Inflamação e insuficiência cardíaca: será essa a ligação para a cardiotoxicidade induzida pela doxorrubicina?Inflamação e insuficiência cardíaca: será essa a ligação para a cardiotoxicidade induzida pela doxorrubicina?". Paper presented in 3rd National Meeting of Young Researchers on Oncology (III ENJIO), 2021.
  12. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Agravamento tardio dos efeitos moleculares subjacentes a cardiotoxicidade crónica da doxorrubicina num modelo de murganho". Paper presented in 3rd National Meeting of Young Researchers on Oncology (III ENJIO), 2021.
  13. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. "A neurotoxicidade de longo prazo da doxorrubicina no cérebro de ratinhos CD-1 adultos.". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, Porto, Portugal, 2021.
  14. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Corresponding author: Dias-Carvalho, Ana. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in Ciência 2021 Science and Technology in Portugal Summit, Lisbon, Portugal, 2021.
  15. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Unveiling the effects of doxorubicin and mitoxantrone on cardiac metabolism, homeostasis, and autophagy in a mice model". Paper presented in III Iberian Journeys of Toxicology (III JIT), UBIPHARMA Online Congress, 2021.
  16. Ana Dias-Carvalho; Mariana Ferreira; Ana Olívia Fernandes; Reis-Mendes, Ana; Margarida Duarte-Araújo; Rita Ferreira; Félix Carvalho; et al. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in III Iberian Journeys of Toxicology (III JIT), UBIPHARMA Online Congress, 2021.
  17. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Disclosing the cardiotoxic effects of the anticancer agents doxorubicin and mitoxantrone on cardiac metabolism, homeostasis and autophagy using CD-1 mice". Paper presented in Ciência 2021 – Science and Tecnology in Portugal Summit, Fundação para a ciência e a Tecnologia (FCT) & Ciência Viva, Lisbon Congress Centre, 2021.
  18. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Chemobrain: assessing the potential to recovery from doxorubicin-induced-neurotoxic effects in CD-1 mice". Paper presented in 14º Encontro de Investigação Jovem da U. Porto (IJUP ¿21), 2021.
  19. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Doxorubicin Increases Apoptotic Markers in the hipocampal formation of CD-1 mice". Paper presented in VI jornadas da Bioquímica: ¿O passaporte para a inovação¿, 2021.
  20. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in 14th Meeting of young researches of U. Porto (IJUP ¿21), 2021.
  21. Reis-Mendes, Ana; Francisca Espincho; Margarida Duarte-Araújo; Duarte, José Alberto; Remião, Fernando; Emilia Sousa; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa. "Short-term and long term renal and hepatic toxicity of doxorubicin". Paper presented in 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  22. Mariana Ferreira; Ana Dias-Carvalho; Reis-Mendes, Ana; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice". Paper presented in 14th Youth Researchers Meeting for students of Porto University (IJUP2021), 2021.
  23. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in XII Biochemistry Day, 2021.
  24. Baltazar, Telmo S.; Anjos, Miguel; Moreira-Pais, Alexandra; Reis-Mendes, Ana; Costa, Vera M.; Ferreira, Rita. "Impact of doxorubicin on skeletal muscle remodeling in young vs. old mice". Paper presented in XII Biochemistry Day, 2021.
  25. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Corresponding author: Dias-Carvalho, Ana. "The long-term neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in Congress of the European Societies of Toxicology (EUROTOX Congress 2021), 2021.
  26. Sofia Reis Brandão; Reis-Mendes, Ana; Margarida Duarte Araújo; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "The influence of the anticancer drugs doxorubicin and mitoxantrone on cardiac metabolism and autophagy". Paper presented in 56th Congress of the European Societies of Toxicology (Eurotox 2021). Online Congress, 2021.
  27. Carvalho, Ana Rita; Reis-Mendes, Ana; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Sá, Susana I; Costa, Vera M. "Neurotoxicidade da mitoxantrona e doxorrubicina: estudo in vivo em diferentes idades". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  28. Sánchez-Momblona, Marina; Dionísio, Flávio; Reis-Mendes, Ana Filipa ; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria De Lourdes; Costa, Vera M. "The effects of doxorubicin and mitoxantrone in the spleen of mice at different ageing stages". Paper presented in 13rd Meeting of young researchers of University Porto, 2020.
  29. Susana I. Sá; Ana Dias Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Félix Carvalho; Maria de Lourdes Bastos; João Paulo Capela; Vera Marisa Costa. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in cd-1 mice". Paper presented in SIFFUP - Simpósio de Investigação da FFUP, 2020.
  30. Reis-Mendes, Ana; Margarida Duarte-Araújo; José Alberto Duarte; Salomé Gonçalves-Monteiro; Félix Carvalho; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. "Anticancer drugs-induced toxicity in different age male CD-1 mice". Paper presented in 5th International Electronic Conference on Medicinal Chemistry (ECMC 2019). Online Congress, 2019.
  31. Sofia Reis Brandão; Reis-Mendes, Ana; Félix Carvalho; Maria Lourdes Bastos; Rita Ferreira; Vera Marisa Costa. "Disclosing the effect of doxorubicin and mitoxantrone on cardiac mitochondrial proteome: an in vivo approach using a murine model". Paper presented in 5th International Electronic Conference on Medicinal Chemistry (ECMC 2019). Online Congress, 2019.
  32. Ana Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Félix Carvalho; Susana I. Sá; João Paulo Capela; Vera Marisa Costa. "Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study". Paper presented in 5th International Electronic Conference on Medicinal Chemistry (ECMC 2019). Online Congress, 2019.
  33. Ana Carvalho; Reis-Mendes, Ana; Margarida Duarte-Araújo; Rita Guedes; Salomé Gonçalves-Monteiro; Félix Carvalho; Maria Lourdes Bastos; João Paulo Capela; Vera Marisa Costa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Paper presented in 55th Congress of the European Societies of Toxicology, Helsinki, Finland (Eurotox 2019), 2019.
  34. Sofia Reis Brandão; Reis-Mendes, Ana; Félix Carvalho; Maria Lourdes Bastos; Rita Ferreira; Vera Marisa Costa. "Exploring the effect of anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial plasticity using a proteomic approach". Paper presented in 55th Congress of the European Societies of Toxicology, Helsinki, Finland (Eurotox 2019), 2019.
  35. Reis-Mendes, Ana; Margarida Duarte-Araújo; José Alberto Duarte; Salomé Gonçalves-Monteiro; Félix Carvalho; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. Corresponding author: Reis-Mendes, Ana. "Evaluation of the toxicity induced by doxorubicin in different age male CD-1 mice". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", 2019.
  36. Reis-Mendes, A.; Margarida Duarte-Araújo; José Alberto Duarte; Félix Carvalho; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. Corresponding author: Reis-Mendes, A.. "Mitoxantrone-induced toxicity in different age male CD-1 mice". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", 2019.
  37. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Differential effects of doxorubicin and mitoxantrone in the brain redox status of differently aged mice". Paper presented in 10th Annual International (bio)Medical Students Meeting, 2019.
  38. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "The effects of doxorubicin and mitoxantrone in brain glutathione levels of differently aged mice". Paper presented in iMed Conference® 10.0, 2018.
  39. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Metabolites in H9c2 Cardiac Differentiated Cells". Paper presented in 54th Congress of European Societies of Toxicology, (Eurotox 2018) Brussels, Belgium, 2018.
  40. Guedes, Rita; Cravo, Sara; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of metabolism on MTX-induced toxicity: a pharmacokinetic study using adult and infant male CD-1 mice". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChemSicily2018), Palermo, Italy, 2018.
  41. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Main metabolites of 5-fluorouracil + adriamycin + cyclophosphamide (FAC) are not major contributors to FAC toxicity in H9c2 cardiac differentiated cells". Paper presented in International Symposium - MitoPorto - mitochondrial evolution, metabolism and disease, Porto, Portugal, 2018.
  42. Guedes, Rita; Reis-Mendes, Ana; Gonçalves-Monteiro, Salomé; Capas, Sara; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of age on mitoxantrone-induced toxicity: an in vivo study using adult and infant CD-1 male mice". Paper presented in XI Encontro Nacional de Estudantes de Bioquímica, Porto, Portugal, 2018.
  43. Alves, Marisa; Reis-Mendes, Ana; Carvalho, Félix; Remião, Fernando; Bastos, Maria Bastos; Costa, Vera M. "Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells to evaluate pixantrone cardiotoxicity". Paper presented in 11st Meeting of young researchers of University Porto (IJUP ¿18), Porto, Portugal, 2018.
  44. Rita Guedes; Reis-Mendes, Ana; Salomé Gonçalves-Monteiro; Sara Capas; Margarida Duarte-Araújo; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. "Mitoxantrone-induced toxicity in adult and infant male CD-1 mice". Paper presented in 11th Youth Researchers Meeting for students of Porto University (IJUP2018), 2018.
  45. Reis-Mendes, Ana; Ana Sara Gomes; Rui A. Carvalho; Fernando Remião; Félix Carvalho; Madalena Pinto; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. Corresponding author: Reis-Mendes, Ana. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Paper presented in Summer Course – Pharmaceutical Drugs: How to obtain, How do they work and Why. A Perspective in Pharmaceutical medicinal chemistry, 2016.
  46. Reis-Mendes, A.; Ana Sara Gomes; Rui A. Carvalho; Fernando Remião; Félix Carvalho; Madalena Pinto; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. Corresponding author: Reis-Mendes, A.. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Paper presented in 51st Congress of the European Societies of Toxicology, Porto (Eurotox 2015), 2015.
  47. Reis-Mendes, Ana; Ana Sara Gomes; Rui A. Carvalho; Fernando Remião; Félix Carvalho; Madalena Pinto; Maria Lourdes Bastos; Emília Sousa; Vera Marisa Costa. "The cardiotoxicity of mitoxantrone: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Paper presented in Summer Course – Pharmaceutical Drugs: How to obtain, How do they work and Why. A Perspective in Pharmaceutical medicinal chemistry, 2015.
  48. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "The cardiotoxicity of mitoxantrone: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Paper presented in IJUP15 8th Meeting of Your Researchers of the University of Porto, 2015.
  49. Reis-Mendes, A.; Emilia Sousa; Fernando Remião; Félix Carvalho; Maria de Lourdes Bastos; Vera Marisa Costa. "At pharmacology relevant concentrations, mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells with autophagy involvement". Paper presented in 50th Congress of the European Societies of Toxicology, Edinburgh (Eurotox 2014), September., 2014.
    10.1016/j.toxlet.2014.06.819
  50. Reis-Mendes, Ana; Emília Sousa; Fernando Remião; Félix Carvalho; Maria Lourdes Bastos; Vera Marisa Costa. Corresponding author: Reis-Mendes, Ana. "Mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells at pharmacological relevant concentrations". Paper presented in 7th Youth Researchers Meeting for students of Porto University (IJUP2014), 2014.
Journal article
  1. Helena Ramos; Reis-Mendes, Ana; Marta Silva; Mafalda Ribeiro; Ana Margarida Araujo; Cristiane Borges; Olga Viegas; et al. "Exposure Scenarios for Estimating Contaminant Levels in Healthy Sustainable Dietary Models: Omnivorous vs. Vegetarian". Food 13 (2024): 10.3390/foods13223659.
    Published • 10.3390/foods13223659
  2. Alexandra Moreira-Pais; Rita Ferreira; Telmo Baltazar; Maria João Neuparth; Rui Vitorino; Ana Reis-Mendes; Vera Marisa Costa; Paula A. Oliveira; José A. Duarte. "Long-term effects of the chronic administration of doxorubicin on aged skeletal muscle: An exploratory study in mice". Biochemical and Biophysical Research Communications (2024): https://doi.org/10.1016/j.bbrc.2024.150650.
    10.1016/j.bbrc.2024.150650
  3. Brandão, Sofia Reis; Oliveira, Pedro Fontes; Guerra-Carvalho, Bárbara; Reis-Mendes, Ana; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Enduring metabolic modulation in the cardiac tissue of elderly CD-1 mice two months post mitoxantrone treatment". Free Radical Biology and Medicine 223 (2024): 199-211. http://dx.doi.org/10.1016/j.freeradbiomed.2024.07.029.
    Published • 10.1016/j.freeradbiomed.2024.07.029
  4. Dias-Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, Ana; Ferreira, Rita; de Lourdes Bastos, Maria; Fernandes, Eduarda; Sá, Susana Isabel; et al. "Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice". Heliyon 10 11 (2024): e31608. http://dx.doi.org/10.1016/j.heliyon.2024.e31608.
    10.1016/j.heliyon.2024.e31608
  5. Ana Reis-Mendes; Cláudia Vitorino-Oliveira; Mariana Ferreira; Félix Carvalho; Fernando Remião; Emília Sousa; Maria de Lourdes Bastos; Vera Marisa Costa. "Comparative In Vitro Study of the Cytotoxic Effects of Doxorubicin’s Main Metabolites on Cardiac AC16 Cells Versus the Parent Drug". Cardiovascular Toxicology (2024): https://doi.org/10.1007/s12012-024-09829-6.
    10.1007/s12012-024-09829-6
  6. Ana Reis-Mendes; Mariana Ferreira; Ana Isabel Padrão; José Alberto Duarte; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; et al. "The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time". Inflammation (2024): https://doi.org/10.1007/s10753-023-01908-0.
    10.1007/s10753-023-01908-0
  7. Germán Ortuño-Hernández; Marta Silva; Rosa Toledo; Helena Ramos; Reis-Mendes, Ana; David Ruiz; Pedro Martínez-Gómez; Isabel M.P.L.V.O. Ferreira; Juan Salazar. "Nutraceutical profile characterization in apricot (Prunus armeniaca L.) fruits". Food Chemistry (2024):
    Submitted
  8. Sofia Reis Brandão; Elisa Lazzari; Rui Vitorino; Germana Meroni; Reis-Mendes, Ana; Maria João Neuparth; Francisco Amado; et al. "Comprehensive ubiquitome analysis reveals persistent mitochondrial remodeling disruptions from doxorubicin-induced cardiotoxicity in aged mice". Basic Research in Cardiology (2024):
    Submitted
  9. Ana Reis-Mendes; Mariana Ferreira; José Alberto Duarte; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; Emília Sousa; Maria Lourdes Bastos; Vera Marisa Costa. "The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-023-03586-1.
    10.1007/s00204-023-03586-1
  10. Sofia Reis Brandão; Ana Reis-Mendes; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "The Metabolic Fingerprint of Doxorubicin-Induced Cardiotoxicity in Male CD-1 Mice Fades Away with Time While Autophagy Increases". Pharmaceuticals (2023): https://doi.org/10.3390/ph16111613.
    10.3390/ph16111613
  11. Ana Dias-Carvalho; Ana Margarida-Araújo; Ana Reis-Mendes; Catarina Oliveira Sequeira; Sofia Azeredo Pereira; Paula Guedes de Pinho; Félix Carvalho; et al. "A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241713126.
    10.3390/ijms241713126
  12. Sofia Brandão; Ana Reis-Mendes; Margarida Duarte-Araújo; Maria Neuparth; Hugo Rocha; Félix Carvalho; Rita Ferreira; Vera Costa. "Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice". Biomolecules (2023): https://doi.org/10.3390/biom13060921.
    10.3390/biom13060921
  13. Ana Reis-Mendes; Félix Carvalho; Fernando Remião; Emília Sousa; Maria de Lourdes Bastos; Vera Marisa Costa. "Autophagy (but not metabolism) is a key event in mitoxantrone-induced cytotoxicity in differentiated AC16 cardiac cells". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-022-03363-6.
    10.1007/s00204-022-03363-6
  14. Sara Maia; Girgis, Beshoy; Grace Fernanda Severino Nunes; Reis-Mendes, Ana; Antonio Bovolini; Duarte, José Alberto. "Splenic morphologic changes induced by a strenuous and exhaustive training program in Wistar rats". Journal of Sports Medicine and Physical Fitness (2022): 873-882.
    Published • 10.23736/S0022-4707.21.12251-0
  15. Ana Reis-Mendes; Ana Isabel Padrão; José Alberto Duarte; Salomé Gonçalves-Monteiro; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; et al. "Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice". Biomolecules 11 11 (2021): 1725-1725. https://doi.org/10.3390/biom11111725.
    10.3390/biom11111725
  16. Ana Mendes; José Luís Sousa; Ana Isabel Padrão; Margarida Duarte-Araújo; José Alberto Ramos Duarte; Vítor Seabra; Salomé Gonçalves-Monteiro; et al. "Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/6/510.
    10.3390/ph14060510
  17. Sampaio-Dias, Ivo E.; Reis-Mendes, Ana; Costa, Vera Marisa; García-Mera, Xerardo; Brea, José; Loza, María Isabel; Pires-Lima, Beatriz L.; et al. "Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide". Journal of Medicinal Chemistry 64 9 (2021): 6209-6220. http://dx.doi.org/10.1021/acs.jmedchem.1c00252.
    Published • 10.1021/acs.jmedchem.1c00252
  18. Brandão, Sofia Reis; Reis-Mendes, Ana; Domingues, Pedro; Duarte, José Alberto; Bastos, Maria Lourdes; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model". (2021): http://hdl.handle.net/10773/37200.
    10.1016/j.tox.2021.152852
  19. Grace Fernanda Severino Nunes; Edyla Camelo; Antonio Bovolini; Catarina Cardoso; Sara Maia; Ana Reis-Mendes; Luis Cuadrado Martin; José Alberto R. Duarte. "Cardiac Structural Repercussions Induced by Exhaustive Physical Training in the Animal Model". Archives of Cardiology and Cardiovascular Diseases 3 2 (2020): 26-35.
    Published
  20. Reis-Mendes, Ana; Félix Carvalho; Fernando Remiao; E Sousa; Maria de Lourdes Bastos; Costa, V M. "The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells". Biomolecules (2019): https://www.mdpi.com/2218-273X/9/3/98.
    10.3390/biom9030098
  21. Maria Pereira-Oliveira; Reis-Mendes, Ana; Félix Carvalho; Fernando Remiao; Maria de Lourdes Bastos; Costa, V M. "Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells". Biomolecules (2019): http://www.mdpi.com/2218-273X/9/1/21.
    10.3390/biom9010021
  22. Reis-Mendes A; Alves M; Carvalho F; Remião F; Bastos ML; Costa VM. "Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells.". Interdisciplinary toxicology (2018): http://europepmc.org/abstract/med/30181708.
    10.2478/intox-2018-0002
  23. Reis-Mendes, A.; Carvalho, F.; Sousa, E.; Remiao, F.; Bastos, M. D. L.; Costa, V. M.. "Cardiotoxicity of FAC (5-Fluorouracil plus Adriamycin plus Cyclophosphamide) Metabolotes in H9c2 Cardiac Differentiated Cells". Toxicology Letters (2018): https://publons.com/publon/21286425/.
    10.1016/J.TOXLET.2018.07.029
  24. A. Reis-Mendes; A. S. Gomes; R. A. Carvalho; F. Carvalho; F. Remião; M. Pinto; M. L. Bastos; E. Sousa; V. M. Costa. "Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy". Archives of Toxicology (2016): http://dx.doi.org/10.1007/s00204-016-1839-z.
    10.1007/s00204-016-1839-z
  25. Filipa Reis-Mendes, Ana; Sousa, Emília; de Lourdes Bastos, Maria; Marisa Costa, Vera. "The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity". Current Drug Metabolism 17 1 (2015): 75-90. http://dx.doi.org/10.2174/1389200216666151103114926.
    10.2174/1389200216666151103114926
Online resource
  1. Ramos, H; Reis-Mendes, A.; Martins, Z. E; Borges, C. B; Araujo, A. M; Silva, M; Ribeiro, M; et al. DIETxPOSOME: a FAIR database detailing food contaminants occurrence in selected foods. 2024. https://doi.org/10.5281/zenodo.12584594.
Thesis / Dissertation
  1. "Inflammation and redox homeostasis disruption (but not metabolism) are major contributors to the cardiotoxicity of mitoxantrone and doxorubicin: in vitro and in vivo studies on differently aged mice". PhD, Universidade do Porto Faculdade de Farmácia, 2024. https://hdl.handle.net/10216/158377.
  2. Mendes, Ana. "The synthesis and in vitro toxicological evaluation of the mitoxantrone naphthoquinoxaline metabolite: a comparative study with the parent drug". Master, Universidade do Porto Faculdade de Farmácia, 2014. http://repositorio-aberto.up.pt/bitstream/10216/77095/2/103849.pdf.
  3. "Apo E and Behçet Disease". Degree, Universidade do Porto Faculdade de Ciências, 2012.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/09 Biomonitoring the exposure to diet contaminants through saliva IUFOST 2024 – 22nd World Congress of Food Science and Technology
IUFOST 2024 (Rimini, Italy)
2024/02 A clinically relevant dose of doxorubicin impacts protein ubiquitination and mitochondrial remodeling in old mice 54ª Reunião da Sociedade Portuguesa de Farmacologia, 42ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia
(Lisboa, Portugal)
2024/02 Long-Term Consequences of Doxorubicin in the Prefrontal Cortex and Hippocampus of CD-1 Mice 54ª Reunião da Sociedade Portuguesa de Farmacologia, 42ª Reunião de Farmacologia Clínica e 23ª Reunião de Toxicologia
(Lisboa, Portugal)
2023/09 Chemobrain: Mitoxantrone effects on the brain’s thiolomic profile of CD-1 mice XXV Conference of Young SIF Pharmacologists 2023
(Urbino, Italy)
2023/04 Cardiac mitochondrial dynamics, autophagy, and regeneration are stirred by doxorubicin in old CD-1 mice II TOXRUN International Congress. TOXRUN – Toxicology Research Unit
Hotel Cristal, Porto (Porto, Portugal)
2023/02 Evaluation of the short-term and long-term cardiotoxicity of doxorubicin: the putative role of inflammation 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (SPF2023)
Coimbra (Coimbra, Portugal)
2023/02 Doxorubicin-induced neurotoxicity affects dissimilarly the hippocampal formation subregions in adult mice: a chemobrain study 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (SPF2023)
Coimbra (Coimbra, Portugal)
2023/02 Cardiac metabolism, proteolysis, and regeneration are disturbed by mitoxantrone in old CD-1 mice 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (SPF2023)
Coimbra (Coimbra, Portugal)
2022/11 Unveiling the neurotoxicity of mitoxantrone: oxidative stress, apoptosis, and autophagy in the brain of adult CD-1 mice 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022). Online Congress
2022/05 The mitoxantrone neurotoxicity evaluated in CD-1 mice: a focus on cell death, redox homeostasis and astrogliosis 15th Youth Researchers Meeting for students of Porto University (IJUP2022)
Porto (Porto, Portugal)
2022/04 Molecular alterations underlying doxorubicin’s chronic cardiotoxicity in a mouse model I International Congress of ToxRun and V Congress of the Portuguese Association of Forensic Sciences
Porto (Porto, Portugal)
2022/04 Mitoxantrone-induced neurotoxicity in CD-1 mice II TOXRUN International Congress. TOXRUN – Toxicology Research Unit
Hotel Cristal, Porto (Porto, Portugal)
2022/02 Mitoxantrone causes oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology (SPF2022)
FFUP (Porto, Portugal)
2022/02 Molecular effects underlying late cardiotoxicity induced by doxorubicin in CD-1 mice 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology and 21st Meeting of Toxicology (SPF2022)
FFUP (Porto, Portugal)
2022/02 Evaluation of short-term and long-term cardiotoxicity of doxorubicin: The putative role of inflammation 52nd Meeting of the Portuguese Society of Pharmacology, 40th Meeting of Clinical Pharmacology, and 21st Meeting of Toxicology (SPF 2022)
FFUP (Porto, Portugal)
2021/05 The effects of doxorubicin and mitoxantrone in the brain of adult mice 14th Youth Researchers Meeting for students of Porto University (IJUP2021)
Porto (Porto, Portugal)
2021/05 Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study 14th Youth Researchers Meeting for students of Porto University (IJUP2021)
Porto (Porto, Portugal)
2021/02 Chemobrain: evaluation of doxorubicin and mitoxantrone neurotoxicity in cd-1 mice 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology (SPF 2021)
Lisboa (Lisboa, Portugal)
2021/02 Inflammatory Pathway involvement on Mitoxantrone-induced cardiotoxicity: an in vivo study 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of the Clinical Pharmacology and 20th Meeting of the Toxicology (SPF 2021)
Lisboa (Lisboa, Portugal)
2020/11 Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice 2ª Edição do Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto (FFUP)
Porto (Porto, Portugal)
2020/09 Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ‘chemobrain’ study on clinically relevant doses Neurosciences Parallel Oral Session in the 15th Young European Scientist (YES), Meeting Faculty of Medicine of the University of Porto
FMUP (Porto, Portugal)
2020/02 The effects of doxorubicin and mitoxantrone in the brain of different age mice: in vivo chemobrain study 13th Youth Researchers Meeting for students of Porto University (IJUP 2020)
Porto (Porto, Portugal)
2020/02 Evaluation of the toxicity induced by anticancer drugs in male CD-1 mice at different aging stages: an in vivo study 50th Meeting of the Portuguese Society of Pharmacology, 38th Meeting of Clinical Pharmacology, and 19th Meeting of Toxicology (SPF 2020)
Coimbra (Coimbra, Portugal)
2020/02 The effects of doxorubicin and mitoxantrone in mice brain at different aging stages: an in vivo chemobrain study 50th Meeting of the Portuguese Society of Pharmacology, 38th Meeting of Clinical Pharmacology, and 19th Meeting of Toxicology (SPF 2020)
Coimbra (Coimbra, Portugal)
2020/02 Effects of doxorubicin and mitoxantrone on mice cardiac mitochondrial proteome 50th Meeting of the Portuguese Society of Pharmacology, 38th Meeting of Clinical Pharmacology, and 19th Meeting of Toxicology (SPF 2020)
Coimbra (Coimbra, Portugal)
2019/09 In vivo chemobrain study: The effects of doxorubicin and mitoxantrone in the brain of differently aged mice 14th Young European Scientist (YES), Meeting Faculty of Medicine of the University of Porto
FMUP (Porto, Portugal)
2019/02 Doxorubicin and mitoxantrone effects on the brain´s redox status of differently aged mice 12th Youth Researchers Meeting for students of Porto University (IJUP2019)
Porto (Porto, Portugal)
2019/02 Effects of doxorubicin and mitoxantrone in brain glutathione of different aged mice: an in vivo study 49th Meeting of the Portuguese Society of Pharmacology, 37th Meeting of Clinical Pharmacology, and 18th Meeting of Toxicology (SPF 2019)
Porto (Porto, Portugal)
2018/09 Differential effects of doxorubicin and mitoxantrone in brain glutathione levels of different aged mice 13th Young European Scientist (YES), Meeting Faculty of Medicine of the University of Porto
FMUP (Porto, Portugal)
2018/07/10 Main metabolites of 5-Fluorouracil + adriamycin + cyclophosphamide (FAC) are not major contributors to FAC toxicity in H9c2 cardiac differentiated cells Manhã do Departamento de Ciências Biológicas da FFUP
FFUP (Porto, Portugal)
2018/02 Cardiotoxic effects of the main metabolites of FAC (5-fluorouracil + adriamycin + cyclophosphamide) in H9c2 differentiated cells 48th Meeting of the Portuguese Society of Pharmacology, 36th Meeting of Clinical Pharmacology, and 17th Meeting of Toxicology (SPF 2018)
Lisboa (Lisboa, Portugal)
2017/07 Old Sources for New Drugs: Challenges and Opportunities XXV Encontro Nacional de Química
Lisboa (Lisboa, Portugal)
2017/02 Mitoxantrone and its naphthoquinoxaline metabolite: A comparative study in differentiated H9c2 cells 47th Meeting of the Portuguese Society of Pharmacology, 35th Meeting of Clinical Pharmacology, and 16th Meeting of Toxicology (SPF 2017)
Coimbra (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/12/30 - Current Novos PFAS, novos riscos? Estudo Comparativo dos Efeitos Cardiotóxicos de PFAS Legado e Emergentes em Células H9c2 Diferenciadas
Supervisor
 Biochemistry Graduation (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2024 - Current The Heart's Hidden Enemy: Unravelling the Mechanisms of PFAS-induced Cardiotoxicity
Supervisor
 Integrated Master in Pharmaceutical Sciences (Project I) (Other)
Universidade do Porto Faculdade de Farmácia, Portugal
2020/09/01 - 2021/07 The Long-Term Toxicity of Doxorubicin: in vivo studies in adult mice
Co-supervisor
 Biochemistry Graduation (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09 - 2020/07 The neurotoxicity of catecholamines and in vitro methods for its evaluation
Co-supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/02/28 - 2017/06/06 A cytotoxicity study of pixantrone in non-differentiated H9c2 cells
Co-supervisor
 Biochemistry Degree (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/04/09 - 2024/04/11 Organization Committee of the ICFD 2024 – 8th International Conference on Food Digestion (2024/04/09 - 2024/04/11)
Congress (Member of the Organising Committee)
 REQUIMTE/Department of Chemical Sciences, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal, Portugal
2019/02/06 - 2019/02/08 XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia (2019/02/06 - 2019/02/08)
Congress (Other)
 Universidade do Porto Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/06/20 Microplastics and nanoplastics as emerging food contaminants: a threat to human health
(Thesis) Main arguer
 Ana Carolina Mota Rosa (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2021/07/22 The Long-Term Toxicity of Doxorubicin: in vivo studies in adult mice
Supervisor
 Maria Francisca Tavares Brochado Teixeira Espincho (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/07/28 The neurotoxicity of catecholamines and in vitro methods for its evaluation
Supervisor
 Mónica Isabel Amorim Marques (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/06 A cytotoxicity study of pixantrone in non-differentiated H9c2 cells
Supervisor
 Marisa Alexandra Pinto Alves (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024 - Current Inflammation Elsevier
2024 - Current Cell Biochemistry and Biophysics Springer
2024 - Current Medical Oncology Springer
2023 - Current Archives of Toxicology (0340-5761) Springer
2021 - Current Cardiovascular Toxicology (1530-7905) Springer
2021 - Current Toxicology and Applied Pharmacology (0041-008X) Elsevier
2019 - Current Brazilian Journal of Pharmaceutical Sciences
2017 - Current Critical Reviews in Oncology / Hematology Elsevier

Consulting

Activity description Institution / Organization
2024/10 - Current External Advisor for Global Burden of Disease Studies (GBD) Institute for Health Metrics and Evaluation (IHME), University of Washington, United States, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/02/18 - 2018/02/28 Monitoring of laboratory classes from the curricular unit ‘Toxicologia Mecanística’ from the 4th year of the Integrated Master in Pharmaceutical Sciences. Faculty of Pharmacy, University of Porto Integrated Master in Pharmaceutical Sciences (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal

Mentoring / Tutoring

Topic Student name
2024/06 - 2024/07 ERASMUS Mobility Germán Ortuño Hernández
2021 - 2023 Unveiling the neurotoxic mechanisms of anticancer drugs: combining insights from neuronal and glial contributions to chemobrain Ana Rita Carvalho
2021 - 2023 Evaluation of the short-term and long-term cardiotoxicity of doxorubicin: the putative role of inflammation Mariana Ferreira
2021/11/05 - 2022/12/06 The study of the cardiotoxicity of targeted anticancer drugs: an in vitro metabolomics study Tânia Gomes
2018 - 2022 Cardiac remodeling persists as an enduring cardiotoxic effect of doxorubicin and mitoxantrone: insights from non-clinical studies conducted on adult and elderly mice Sofia Reis Brandão
2021/03/29 - 2021/09/30 ERASMUS Mobility Elisa Milandri
2019 - 2021 Splenic morphologic changes induced by a strenuous and exhaustive training program in Wistar rats Sara Maia - Master Student
2019 - 2021 The neurotoxicity of doxorubicin and mitoxantrone: Chemobrain studies using infant, adult, and old mice Ana Rita Carvalho - Master Student
2019/09/15 - 2020/01/31 ERASMUS Mobility Marina Sanchez-Momblona
2018 - 2020 Cardiac Structural Repercussions Induced by Exhaustive Physical Training in the Animal Model Grace Fernanda Severino Nunes
2017 - 2018/12 The influence of age on the toxicity induced by mitoxantrone: in vivo studies with mice Rita Alexandra Morais Guedes - Master Student
Distinctions

Award

2021 3rd prize in the Best Free Communication Award to the poster - Unveiling the effects of doxorubicin and mitoxantrone on cardiac metabolism, homeostasis, and autophagy in a mice model. III Iberian Journeys of Toxicology (III JIT)
UBIPHARMA , Portugal
2021 Honorable Mention in the Best Communication Award to the oral - Doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study
Universidade de Aveiro, Portugal
2021 1st prize in the Best Communication Award to the oral - Impact of doxorubicin on skeletal muscle remodelling in young vs. old mice
Universidade de Aveiro, Portugal
2020 Second best oral presentation in the health sciences category - The effects of doxorubicin and mitoxantrone in the brain of different age mice: in vivo chemobrain study
Universidade do Porto, Portugal
2020 Second best oral presentation - Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice
Universidade do Porto, Portugal