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Presently, Ana Reis-Mendes is a researcher in the project: "Novel tools for exposure assessment of food contaminants by saliva multiple biomarker monitoring", financed by the Portuguese Foundation of Science and Technology 2022.08978.PTDC in REQUIMTE/Department of Chemical Sciences, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal. Ana Reis-Mendes is a Ph.D. student (SFRH/BD/129359/2017) and is involved in the project: "Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?", financed by the Portuguese Foundation of Science and Technology PTDC/DTP-FTO/1489/2014 and POCI-01-0145-FEDER-016537 in UCIBIO-REQUIMTE (Rede de Química e Tecnologia), Toxicology Laboratory, Department of Biological Sciences, Faculty of Pharmacy, University of Porto. Ana Reis-Mendes has 18 research works with 129 citations, including: "Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy" and "The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice". The cardiotoxicity is the main area of expertise, along with the side effects of anticancer drugs.
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Identification

Personal identification

Full name
Ana Filipa Reis Mendes

Citation names

  • Reis-Mendes, Ana
  • Reis-Mendes, Ana Filipa
  • Reis-Mendes, A.

Author identifiers

Ciência ID
0E17-0F19-79B9
ORCID iD
0000-0002-2775-3147
Researcher Id
T-3712-2017
Scopus Author Id
57050347000

Telephones

Telephone
  • 220428596 (Professional)

Addresses

  • LAQV/REQUIMTE - Laboratory of Bromatology and Hidrology, Faculty of Pharmacy, University of Porto Rua de Jorge Viterbo Ferreira, 228, 4050-313, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Natural sciences - Biological Sciences - Microbiology
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Portuguese (Mother tongue)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2018/02/01 - 2022/02/01
Ongoing
 PhD in Pharmaceutical Sciences (Doutoramento)
Major in Toxicology
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
"‘Discovering the early biomarkers of cardiotoxicity: is metabolic bioactivation the link to the cardiotoxicity of the anticancer drugs, doxorubicin and mitoxantrone?’" (THESIS/DISSERTATION)
2018/10/08 - 2018/10/12
Concluded
 Practical Course in Laboratory Animal Sciences - Category B (according to FELASA recommendations) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboartório, Portugal
19
2018/10/08 - 2018/10/12
Concluded
 Theoretical Course in Laboratory Animal Science - Category B (according to FELASA recommendations) (Pós-Graduação)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Sociedade Portuguesa de Ciências em Animais de Laboartório, Portugal
17
2017/02/01 - 2018/06/01
Concluded
 PhD course in Pharmaceutical Sciences (Curso de doutoramento (conclusão de unidades curriculares))
Major in Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
 18
2017/05/08 - 2017/05/14
Concluded
 Course on Cardiopulmonary toxicity (Outros)
Univerzita Karlova Lékarská fakulta v Hradci Králové, Czech Republic
2012/09/03 - 2014/11/14
Concluded
 Master in Analytical, Clinical and Forensic Toxicology (Mestrado)
Major in Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
"The synthesis and in vitro toxicological evaluation of the mitoxantrone naphthoquinoxaline metabolite: a comparative study with the parent drug" (THESIS/DISSERTATION)
 16
2009/09/07 - 2012/09/04
Concluded
 Degree in Biochemistry (Licenciatura)
Universidade do Porto Departamento de Química e Bioquímica, Portugal
"Apo E e Doença de Behçet" (THESIS/DISSERTATION)
 13
2007/09/04 - 2008/06/27
Concluded
 Technological Specialization Course (CET) Level IV - Specialization in Microbiology (Curso de Especialização Tecnológica)
Major in Microbologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 15
2006/09/04 - 2007/09/03
Concluded
 Laboratory Technician Course - Microbiology - Level IV (Curso Técnico Superior Profissional)
Major in Microbiologia
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2024/02/01 - Current Researcher (Research) REQUIMTE/Department of Chemical Sciences, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2018/02/01 - 2024/02/01 Researcher (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2023/11/02 - 2024/01/31 Researcher (Research) REQUIMTE/Department of Chemical Sciences, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy, University of Porto, Portugal, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2017/01/16 - 2018/02/01 Researcher (Research) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2016/02/12 - 2017/01/15 Researcher (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2013/07 - 2015/09 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2011/11 - 2012/09 Research Trainee (Research) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Departamento de Química e Bioquímica, Portugal
(...)
2011/03 - 2011/07 Research Trainee (Research) REQUIMTE LAQV Porto, Portugal
REQUIMTE LAQV Porto, Portugal
2007/11 - 2008/02 Research Trainee (Research) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2008/10 - 2009/10 Laboratory Technician Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
2008/03 - 2008/09 Traineeship as Laboratory Technician Equilibrium – Laboratório de Controlo de Qualidade e de Processos, Lda , Portugal
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Grant

Designation Funders
2024/01/01 - Current SALIVA+ - Novel tools for exposure assessment of food contaminants by saliva multiple biomarker monitoring
2022.08978.PTDC
Research Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/20 - 2023/06/19 Discovering the early biomarkers of cardiotoxicity: is metabolic bioactivation the link to the cardiotoxicity of the anticancer drugs, doxorubicin and mitoxantrone
COVID/BD/152374/2022
 Fundação para a Ciência e a Tecnologia
Concluded
2018/02/01 - 2021/02/01 Discovering the early biomarkers of cardiotoxicity: is metabolic bioactivation the link to the cardiotoxicity of the anticancer drugs, doxorubicin and mitoxantrone?
SFRH/BD/129359/2017
PhD Student Fellow
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/02 - 2017/01/15 “Apoio a laboratórios da Escola de Ciências, designadamente Gestão dos Espaços e Equipamentos Laboratoriais, Aquisição de Bens e Serviços, Controlo de Stocks, Gestão de Conteúdos de Portais Web, Gestão de Coleções Biológicas, Higiene e Segurança de Laboratórios”
UID/BIA/04050
POCI-01-0145-FEDER-007569
Research Technician Fellow
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Ongoing

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CENTRE OF MOLECULAR AND ENVIRONMENTAL BIOLOGY
UID/BIA/04050/2019
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/01/16 - 2019/12/31 Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?
PTDC/DTP-FTO/1489/2014
Research Fellow
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Desporto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/09/01 - 2014/10/31 Why is mitoxantrone a poison to the heart? Focus on mitochondria, cytoskeleton, and metabolic bioactivation mechanisms
EXPL/DTP-FTO/0290/2012
Other
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Desporto, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Dias-Carvalho, Ana; Reis-Mendes, A.; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos ML; Capela JP; Costa VM. "In vivo chemobrain study: the effects of doxorubicin and mitoxantrone in the brain of differently aged mice". Paper presented in Porto Biomed. J., 2019.
    Published
  2. Dias-Carvalho, Ana; Reis-Mendes, A.; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos ML; Sá, SI; Capela JP; Costa VM. "Chemobrain study: differential effects of doxorubicin and mitoxantrone in the brain of CD-1 mice". Paper presented in 1st International Electronic Conference on Brain Sciences., 2019.
Conference paper
  1. Brandão, Sofia; Reis-Mendes, A.; Duarte-Araujo, M.; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Mitoxantrone disrupts cardiac metabolism along with proteolysis and regeneration in aged mice". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, Online, 2022.
    Published
  2. Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, Ana; Ferreira, Rita; Fernandes, Eduarda; Sá, Susana I; Capela, João Paulo; Carvalho, Félix; Costa, Vera M. "Mitoxantrone-induced neurotoxicity in CD-1 mice.". Paper presented in I TOXRUN, Porto, 2022.
    Published
  3. Carvalho, Ana Rita; Reis-Mendes, A.; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Sá, Susana I; Capela, João Paulo; Costa, Vera M. "Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ¿chemobrain¿ study on clinically relevant doses.". Paper presented in 15th YES Meeting Porto 2020, Porto, 2020.
    Published • 10.1097/j.pbj.0000000000000100
  4. Reis-Mendes, Ana; Duarte-Araújo, Margarida; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Remião, Fernando; Carvalho, Félix; Sousa, Emília; Bastos, Maria Lourdes; Costa, Vera Marisa. "Anticancer drugs-induced toxicity in different age male CD-1 mice". 2019.
    10.3390/ecmc2019-06365
  5. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana I.; Capela, João Paulo; Costa, Vera Marisa. "Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study". 2019.
    10.3390/ecmc2019-06364
  6. Ana Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Rita Guedes; Salomé Monteiro; Félix Carvalho; Maria de Lourdes Bastos; João Paulo Capela; Vera Marisa Costa. "Differential effects of doxorubicin and mitoxantrone in brain glutathione levels of different aged mice". 2018.
    Published
Conference poster
  1. Dias-Carvalho, Ana; Araújo, Ana Margarida; Reis-Mendes, A.; Sequeira, CO; Pereira, AS; Guedes de Pinho, Paula; Carvalho, Félix; et al. "Chemobrain: exploring the impacto f a clinically relevant dose of mitoxantrone in the metabolic profile of CD-1 mice brain". Paper presented in EMBO Young Scientists¿ Forum (Lisbon), 2023.
  2. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Reis-Mendes, Ana; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Application of 2-Azanorbornane for the Assembly of Bioactive Peptidomimetics". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, 2023.
  3. Baltazar, Telmo; Moreira-Pais, Alexandra; Reis-Mendes, Ana; Costa, Vera M.; Ferreira, Rita. "Impact of doxorubicin on skeletal muscle oxidative stress in elderly animals". Paper presented in XIII Biochemistry Day, 2022.
  4. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Ferreira, Rita; Fernandes, Eduarda; Sá, Susana I; Sá SI; Capela, João Paulo; Carvalho, Félix; Costa, Vera Marisa. "Evaluation of mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in AIMS Meeting, 2022.
  5. Reis-Mendes, A.; Padrão, A.I.; Duarte-Araújo, M; Duarte, JA; Gonçalves-Monteiro, Salomé; Remião, Fernando; Carvalho, Félix; et al. "Involvement of inflammation in DOX-induced cardiotoxicity: an in vivo study". Paper presented in 56th Congress of the European Societies of Toxicology - Eurotox 2021, 2021.
  6. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. "A neurotoxicidade de longo prazo da doxorrubicina no cérebro de ratinhos CD-1 adultos.". Paper presented in 3º Encontro Nacional de Jovens Investigadores em Oncologia, Porto, Portugal, 2021.
  7. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Corresponding author: Dias-Carvalho, Ana. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in Ciência 2021 ¿ Science and Technology in Portugal Summit, Lisbon, Portugal, 2021.
  8. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Chemobrain: assessing the potential to recovery from doxorubicin-induced-neurotoxic effects in CD-1 mice". Paper presented in 14º Encontro de Investigação Jovem da U. Porto (IJUP ¿21), 2021.
  9. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in 14th Meeting of young researches of U. Porto (IJUP ¿21), 2021.
  10. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Paper presented in XII Biochemistry Day, 2021.
  11. Baltazar, Telmo S.; Anjos, Miguel; Moreira-Pais, Alexandra; Reis-Mendes, Ana; Costa, Vera M.; Ferreira, Rita. "Impact of doxorubicin on skeletal muscle remodeling in young vs. old mice". Paper presented in XII Biochemistry Day, 2021.
  12. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Corresponding author: Dias-Carvalho, Ana. "The long-term neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Paper presented in Congress of the European Societies of Toxicology (EUROTOX Congress 2021), 2021.
  13. Carvalho, Ana Rita; Reis-Mendes, Ana; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Sá, Susana I; et al. "Neurotoxicidade da mitoxantrona e doxorrubicina: estudo in vivo em diferentes idades". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  14. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Doxorubicin Increases Apoptotic Markers in the hipocampal formation of CD-1 mice". Paper presented in VI jornadas da Bioquímica: ¿O passaporte para a inovação¿, 2020.
  15. Sánchez-Momblona, Marina; Dionísio, Flávio; Reis-Mendes, Ana Filipa ; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria De Lourdes; Costa, Vera M. "The effects of doxorubicin and mitoxantrone in the spleen of mice at different ageing stages". Paper presented in 13rd Meeting of young researchers of University Porto, 2020.
  16. Ana Dias Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Carvalho, Félix; Sá, Susana I; Sá SI; Capela, João Paulo; Costa, Vera Marisa; et al. "The effects of doxorubicin and mitoxantrone in mice brain at different aging stages: an in vivo chemobrain study". Paper presented in SPF 2020 ¿ Reunião Anual da Sociedade Portuguesa de Farmacologia, 2020.
  17. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Differential effects of doxorubicin and mitoxantrone in the brain redox status of differently aged mice". Paper presented in 10th Annual International (bio)Medical Students Meeting, 2019.
  18. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "The effects of doxorubicin and mitoxantrone in brain glutathione levels of differently aged mice". Paper presented in iMed Conference® 10.0, 2018.
  19. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Metabolites in H9c2 Cardiac Differentiated Cells". Paper presented in 54th Congress of European Societies of Toxicology, (Eurotox 2018) Brussels, Belgium, 2018.
  20. Guedes, Rita; Cravo, Sara; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of metabolism on MTX-induced toxicity: a pharmacokinetic study using adult and infant male CD-1 mice". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChemSicily2018), Palermo, Italy, 2018.
  21. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Main metabolites of 5-fluorouracil + adriamycin + cyclophosphamide (FAC) are not major contributors to FAC toxicity in H9c2 cardiac differentiated cells". Paper presented in International Symposium - MitoPorto - mitochondrial evolution, metabolism and disease, Porto, Portugal, 2018.
  22. Guedes, Rita; Reis-Mendes, Ana; Gonçalves-Monteiro, Salomé; Capas, Sara; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of age on mitoxantrone-induced toxicity: an in vivo study using adult and infant CD-1 male mice". Paper presented in XI Encontro Nacional de Estudantes de Bioquímica, Porto, Portugal, 2018.
  23. Guedes, Rita; Reis-Mendes, Ana; Gonçalves-Monteiro, Salomé; Capas, Sara; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "Mitoxantrone-induced toxicity in adult and infant male CD-1 mice". Paper presented in 11st Meeting of young researchers of University Porto (IJUP ¿18), Porto, Portugal, 2018.
  24. Alves, Marisa; Reis-Mendes, Ana; Carvalho, Félix; Remião, Fernando; Bastos, Maria Bastos; Costa, Vera M. "An in vitro study with differentiated and non-differentiated H9c2 cells to evaluate pixantrone cardiotoxicity". Paper presented in 11st Meeting of young researchers of University Porto (IJUP ¿18), Porto, Portugal, 2018.
  25. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "The cardiotoxicity of mitoxantrone: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Paper presented in IJUP¿15 ¿ 8th Meeting of Your Researchers of the University of Porto, 2015.
Journal article
  1. Ana Reis-Mendes; Cláudia Vitorino-Oliveira; Mariana Ferreira; Félix Carvalho; Fernando Remião; Emília Sousa; Maria de Lourdes Bastos; Vera Marisa Costa. "Comparative In Vitro Study of the Cytotoxic Effects of Doxorubicin’s Main Metabolites on Cardiac AC16 Cells Versus the Parent Drug". Cardiovascular Toxicology (2024): https://doi.org/10.1007/s12012-024-09829-6.
    10.1007/s12012-024-09829-6
  2. Ana Reis-Mendes; Mariana Ferreira; Ana Isabel Padrão; José Alberto Duarte; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; et al. "The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time". Inflammation (2024): https://doi.org/10.1007/s10753-023-01908-0.
    10.1007/s10753-023-01908-0
  3. Ana Reis-Mendes; Mariana Ferreira; José Alberto Duarte; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; Emília Sousa; Maria Lourdes Bastos; Vera Marisa Costa. "The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-023-03586-1.
    10.1007/s00204-023-03586-1
  4. Sofia Reis Brandão; Ana Reis-Mendes; Maria João Neuparth; Félix Carvalho; Rita Ferreira; Vera Marisa Costa. "The Metabolic Fingerprint of Doxorubicin-Induced Cardiotoxicity in Male CD-1 Mice Fades Away with Time While Autophagy Increases". Pharmaceuticals (2023): https://doi.org/10.3390/ph16111613.
    10.3390/ph16111613
  5. Ana Dias-Carvalho; Ana Margarida-Araújo; Ana Reis-Mendes; Catarina Oliveira Sequeira; Sofia Azeredo Pereira; Paula Guedes de Pinho; Félix Carvalho; et al. "A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241713126.
    10.3390/ijms241713126
  6. Sofia Brandão; Ana Reis-Mendes; Margarida Duarte-Araújo; Maria Neuparth; Hugo Rocha; Félix Carvalho; Rita Ferreira; Vera Costa. "Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice". Biomolecules (2023): https://doi.org/10.3390/biom13060921.
    10.3390/biom13060921
  7. Ana Reis-Mendes; Félix Carvalho; Fernando Remião; Emília Sousa; Maria de Lourdes Bastos; Vera Marisa Costa. "Autophagy (but not metabolism) is a key event in mitoxantrone-induced cytotoxicity in differentiated AC16 cardiac cells". Archives of Toxicology (2023): https://doi.org/10.1007/s00204-022-03363-6.
    10.1007/s00204-022-03363-6
  8. Dias-Carvalho, A.; Ferreira, M.; Reis-Mendes, A.; Ferreira, R.; Bastos, M.L.; Fernandes, E.; Sá, S.I.; et al. "Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice". Archives of Toxicology 96 6 (2022): 1767-1782. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126818986&partnerID=MN8TOARS.
    Accepted • 10.1007/s00204-022-03261-x
  9. Ana Reis-Mendes; Ana Isabel Padrão; José Alberto Duarte; Salomé Gonçalves-Monteiro; Margarida Duarte-Araújo; Fernando Remião; Félix Carvalho; et al. "Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice". Biomolecules 11 11 (2021): 1725-1725. https://doi.org/10.3390/biom11111725.
    10.3390/biom11111725
  10. Ana Mendes; José Luís Sousa; Ana Isabel Padrão; Margarida Duarte-Araújo; José Alberto Ramos Duarte; Vítor Seabra; Salomé Gonçalves-Monteiro; et al. "Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/6/510.
    10.3390/ph14060510
  11. Sampaio-Dias, Ivo E.; Reis-Mendes, Ana; Costa, Vera Marisa; García-Mera, Xerardo; Brea, José; Loza, María Isabel; Pires-Lima, Beatriz L.; et al. "Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide". Journal of Medicinal Chemistry 64 9 (2021): 6209-6220. http://dx.doi.org/10.1021/acs.jmedchem.1c00252.
    Published • 10.1021/acs.jmedchem.1c00252
  12. Brandão, Sofia Reis; Reis-Mendes, Ana; Domingues, Pedro; Duarte, José Alberto; Bastos, Maria Lourdes; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial proteome using a murine model". (2021): http://hdl.handle.net/10773/37200.
    10.1016/j.tox.2021.152852
  13. Grace Fernanda Severino Nunes; Edyla Camelo; Antonio Bovolini; Catarina Cardoso; Sara Maia; Ana Reis-Mendes; Luis Cuadrado Martin; José Alberto R. Duarte. "Cardiac Structural Repercussions Induced by Exhaustive Physical Training in the Animal Model". Archives of Cardiology and Cardiovascular Diseases 3 2 (2020): 26-35.
    Published
  14. Brandão, Sofia; Reis-Mendes, Ana; Carvalho, Félix; Bastos, Maria; Ferreira, Rita; Costa, Vera. "Disclosing the effect of doxorubicin and mitoxantrone on cardiac mitochondrial proteome: an in vivo approach using a murine model". Proceedings of 5th International Electronic Conference on Medicinal Chemistry (2019): http://dx.doi.org/10.3390/ecmc2019-06350.
    10.3390/ecmc2019-06350
  15. Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Toxicology Letters 314 (2019):
    Published • 10.1016/j.toxlet.2019.09.002
  16. Dias-Carvalho, Ana; Reis-Mendes, A.; Duarte-Araújo, M.; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: na in vivo chemobrain study". Toxicology Letters 314 (2019): 223-223.
    Published
  17. Brandão, Sofia; Reis-Mendes, A.; Carvalho, Félix; Bastos, Maria de Lourdes; Ferreira, Rita; Costa, Vera Marisa. "Exploring the effect of anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial plasticity using a proteomic approach". Toxicology Letters 314 (2019): 78-78.
    Published
  18. Reis-Mendes, A.; Duarte-Araújo, M.; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Maria de Lourdes Bastos; Emilia Sousa; Costa, Vera Marisa. "Mitoxantrone-induced toxicity in different age male CD-1 mice". European Journal of Clinical Investigation 49 (2019): 101-221.
    Published
  19. Reis-Mendes, A.; Duarte-Araújo, M.; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Maria de Lourdes Bastos; Emilia Sousa; Costa, Vera. "Evaluation of the toxicity induced by doxorubicin in different age male CD-1 mice". European Journal of Clinical Investigation 49 (2019): 101-221.
    Published • 10.1111/eci.13109
  20. Ana Mendes; Félix Carvalho; Fernando Remiao; E Sousa; Maria de Lourdes Bastos; Costa, V M. "The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells". Biomolecules (2019): https://www.mdpi.com/2218-273X/9/3/98.
    10.3390/biom9030098
  21. Maria Pereira-Oliveira; Ana Mendes; Félix Carvalho; Fernando Remiao; Maria de Lourdes Bastos; Costa, V M. "Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells". Biomolecules (2019): http://www.mdpi.com/2218-273X/9/1/21.
    10.3390/biom9010021
  22. Reis-Mendes A; Alves M; Carvalho F; Remião F; Bastos ML; Costa VM. "Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells.". Interdisciplinary toxicology (2018): http://europepmc.org/abstract/med/30181708.
    10.2478/intox-2018-0002
  23. Reis-Mendes, A.; Carvalho, F.; Sousa, E.; Remiao, F.; Bastos, M. D. L.; Costa, V. M.. "Cardiotoxicity of FAC (5-Fluorouracil plus Adriamycin plus Cyclophosphamide) Metabolotes in H9c2 Cardiac Differentiated Cells". Toxicology Letters (2018): https://publons.com/publon/21286425/.
    10.1016/J.TOXLET.2018.07.029
  24. Hrynchak, Ivanna; Reis-Mendes, A.; Palmeira, A; Bastos, M.L; Costa, Vera M. "Old Pharmaceuticals with New Applications: the Case Studies of Lucanthone and Mitoxantrone.". 3rd International Electronic Conference on Medical Chemistry (2017): 4663. http://dx.doi.org/10.3390/ecmc-3-04663.
    10.3390/ecmc-3-04663
  25. A. Reis-Mendes; A. S. Gomes; R. A. Carvalho; F. Carvalho; F. Remião; M. Pinto; M. L. Bastos; E. Sousa; V. M. Costa. "Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy". Archives of Toxicology (2016): http://dx.doi.org/10.1007/s00204-016-1839-z.
    10.1007/s00204-016-1839-z
  26. Filipa Reis-Mendes, Ana; Sousa, Emília; de Lourdes Bastos, Maria; Marisa Costa, Vera. "The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity". Current Drug Metabolism 17 1 (2015): 75-90. http://dx.doi.org/10.2174/1389200216666151103114926.
    10.2174/1389200216666151103114926
  27. Reis-Mendes, A.; Gomes, A.S.; Carvalho, R.A.; Remião, F.; Carvalho, F.; Pinto, M.; Bastos, M.L.; Sousa, E.; Costa, V.M.. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Toxicology Letters 238 2 (2015): S308-S309. http://dx.doi.org/10.1016/j.toxlet.2015.08.882.
    10.1016/j.toxlet.2015.08.882
  28. Reis-Mendes, Ana; Sousa, Emília; Remião, Fernando; Carvalho, Félix; Bastos, Maria Lourdes; Costa, Vera Marisa. "At pharmacology relevant concentrations, mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells with autophagy involvement". Toxicology Letters 229 (2014): S246. http://dx.doi.org/10.1016/j.toxlet.2014.06.819.
  29. Reis-Mendes, A.. "At pharmacology relevant concentrations, mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells with autophagy involvement". Toxicology Letters, Vol. 229, Supplement: S246 (2014): http://www.sciencedirect.com/science/article/pii/S0378427414010698.
    10.1016/j.toxlet.2014.06.819
Online resource
  1. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana I; Capela, João Paulo; Costa, Vera Marisa. Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study. 2019. https://sciforum.net/paper/view/conference/6364.
Thesis / Dissertation
  1. Mendes, Ana. "“The synthesis and in vitro toxicological evaluation of the mitoxantrone naphthoquinoxaline metabolite: a comparative study with the parent drug”". Master, Universidade do Porto Faculdade de Farmácia, 2014. http://repositorio-aberto.up.pt/bitstream/10216/77095/2/103849.pdf.
  2. Ana Filipa dos Reis Mendes. "The Synthesis and in Vitro Toxicological Evaluation of the Mitoxantrone Naphthoquinoxaline Metabolite: A Comparative Study with the Parent Drug". Master, 2014. https://repositorio-aberto.up.pt/handle/10216/77095.

Other

Other output
  1. Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice. Heliyon. 2022. Dias-Carvalho, A.; Ferreira, M.; Reis-Mendes, A.; Ferreira, R.; Bastos, M.L.; Fernandes, E.; Sá, S.I.; et al. Corresponding author: Dias-Carvalho, Ana. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167496261&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2285298/v1
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01 - 2021/07 The Long-Term Toxicity of Doxorubicin: in vivo studies in adult mice
Co-supervisor
 Biochemistry Graduation (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020/01 - 2020/07 "The neurotoxicity of catecholamines and in vitro methods for its evaluation"
Co-supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/01/04 - 2017/07/06 "A cytotoxicity study of pixantrone in non-differentiated H9c2 cells"
Co-supervisor
 Licenciatura em Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/02/06 - 2019/02/08 XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia (2019/02/06 - 2019/02/08)
Congress (Other)
 Universidade do Porto Faculdade de Farmácia, Portugal