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Rui Miguel Vaz de Abreu. Concluiu o Doutoramento em Genética Molecular Comparativa e Tecnológica em 2011/07/28 pela Universidade de Trás-os-Montes e Alto Douro, Mestrado em Biologia Celular em 2001/04/05 pela Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Bioquímica em 1997/06/14 pela Universidade de Coimbra Faculdade de Ciencias e Tecnologia. É Professor Adjunto no Instituto Politécnico de Bragança e Coordenador do tópico "Ingredientes Naturais e de Base Natural" dentro do grupo de "Processos e Produtos Sustentáveis" no Centro de Investigação de Montanha. Publicou 45 artigos em revistas especializadas. Possui 3 capítulos de livros. Coorientou 4 teses de doutoramento. Orientou 1 dissertação de mestrado e coorientou 4. Coorientou 6 trabalhos de conclusão de curso de licenciatura/bacharelato. Participa ou participou como Investigador em 19 projetos. Atua nas áreas das Ciências Biológicas com ênfase em Bioquímica e Biotecnologia. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: nanopartículas magnéticas; magnetolipossomas; Cogumelos silvestres; QSAR/Docking; Compostos heterocíclicos; Antitumorais e anti-angiogénicos; Modelação molecular; Receptores de factores de crescimento celular; Bioactividade; Nutrição; Produtos Naturais.
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Identification

Personal identification

Full name
Rui Miguel Vaz de Abreu

Citation names

  • Abreu, Rui M.V.

Author identifiers

Ciência ID
0F19-0DE2-12A2
ORCID iD
0000-0002-7745-8015

Telephones

Telephone
  • 273303244 (Professional)

Addresses

  • Escola Superior Agrária de Bragança. Campus de Santa Apolónia - Apartado 1172, 5301-855, BRAGANÇA, Bragança, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Engineering and Technology - Industrial Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2011/07/28
Concluded
 Genética Molecular Comparativa e Tecnológica (Doutoramento)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Antioxidant activity of diarylamines in the benzo[b]thiophene series and antitumoral/antiangiogenic activities of thieno[3,2-b]pyridine derivatives: in vitro studies, QSAR modelling, VEGFR-2 docking and software development" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor, por unanimidade
2001/04/05
Concluded
 Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Efeitos do carvedilol e do seu metabolito BM-910228 na peroxidação lipídica e na bioenegética mitocondrial" (THESIS/DISSERTATION)
 Muito Bom
1997/06/14
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Estudo do efeito de fármacos cardioprotectores na função mitocondrial" (THESIS/DISSERTATION)
 14
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2011/07/31 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Bragança, Portugal
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
2000/09/01 - 2011/07/31 Assistant (Polytechnic Teacher) Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
1999/09/01 - 2000/09/01 Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Bragança Escola Superior Agrária, Portugal

Positions / Appointments

Category
Host institution 		Employer
2020/01/01 - Current Coordenador do tópico "Ingredientes Naturais e de Base Natural" dentro do grupo de "Processos e Produtos Sustentáveis" do Centro de Investigação de Montanha Centro de Investigação de Montanha, Portugal
Centro de Investigação de Montanha, Portugal

Others

Category
Host institution 		Employer
1997/04/01 - 1998/08/01 Técnico de Investigação - BTI Grant, PRAXIS XXI. Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projects

Contract

Designation Funders
2021/01/01 - 2025/12/31 Laboratório para a Sustentabilidade e Tecnologia em Regiões de Montanha
LA/P/0007/2020
10.54499/LA/P/0007/2020
Instituto Politécnico de Bragança, Portugal

Instituto Politécnico de Bragança Centro de Investigação de Montanha, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/07/01 - 2025/06/30 BEONAT - Innovative value chains from tree & shrub species grown in marginal lands as a source of biomass for bio-based industries
BBI-2019-SO1-R1 - 887917
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2020/06/01 - 2024/05/31 UP4HEALTH - Sustainable and cost-effective production process for the upcycling of olive, grape and nut by-products into 4 natural and healthy ingredients for nutraceutical and cosmetic applications
H2020-BBI-JTI-2019 - 888003
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2021/03/29 - 2024/03/28 Silk Sericin as an industrial wastewater with valuable biomedical potential
PTDC/BTA-BTA/0696/2020
10.54499/PTDC/BTA-BTA/0696/2020
Universidade da Beira Interior, Portugal

Instituto Politécnico da Guarda, Portugal

Instituto Politécnico de Bragança, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Instituto Politécnico de Bragança Centro de Investigação de Montanha, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2024/01/01 LOCALNUTLEG - Developing of innovative plant- based added-value food products through the promotion of LOCAL Mediterranean NUT and LEGume crops
PRIMA - TOPIC: 1.3.1-2020
Researcher
Instituto Politécnico de Bragança, Portugal
 EU Framework Programme for Research and Innovation Euratom
Ongoing
2020/01/01 - 2023/12/31 Centro de Investigação de Montanha
UIDP/00690/2020
10.54499/UIDP/00690/2020
Instituto Politécnico de Bragança, Portugal

Instituto Politécnico de Bragança Centro de Investigação de Montanha, Portugal

Instituto Politécnico de Viana do Castelo, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/01/01 - 2023/06/30 OliveBIOextract - Aproveitamento sustentável do bagaço de azeitona numa cadeia de valorização integrada utilizando processos inovadores
NORTE-01-0247-FEDER-049865
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2020/06/01 - 2023/06/30 HealthyPETFOOD - Formulações PetFood para promoção da saúde e qualidade de vida
POCI-01-0247-FEDER-047073
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2020/01/01 - 2022/12/31 PulpIng - Development of Pumpkin Pulp Formulation using a Sustainable Integrated Strategy
PRIMA/0007/2019
Researcher
Centro de Investigação de Montanha, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2018/01/01 - 2021/12/31 TRANSCoLAB - Laboratorio Colaborativo Transfronterizo para la sostenibilidad y innovación del sector Agroalimentario y Agroindustrial
0612_TRANS_CO_LAB_2_P
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2020/07/14 - 2021/07/13 PlantCovid - Aplicações de extratos de plantas com ação dirigida ao SARS-CoV2
NORTE-01-02B7-FEDER-054870
LISBOA-01-02B7-FEDER-054870
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2018/07/01 - 2021/06/30 MAGnetoLIpossomas para terapia DUal do cancro
PTDC/QUI-QFI/28020/2017
Researcher
Centro de Investigação de Montanha, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/30 - 2021/06/29 MicoBioExtract - Integral valorization of by-products resulting from the production of mushrooms in bio-extracts: quality improvement, safety and optimization of the economic metabolism of the production chain
POCI-01-0247-FEDER- 033939
Researcher
Centro de Investigação de Montanha, Portugal
Ongoing
2017/01/01 - 2020/12/31 IBERPHENOL: Red Ibérica de investigación en polifenoles
0377_IBERPHENOL_6_E
Researcher
Centro de Investigação de Montanha, Portugal
Concluded
2017/07/01 - 2020/06/30 Valor Natural: Valorização de recursos naturais através da extração de ingredientes de elevado valor acrescentado para aplicações na indústria alimentar
Norte-01-0247-FEDER-024479
Researcher
Centro de Investigação de Montanha, Portugal
Concluded
2019/01/01 - 2019/12/31 Centro de Investigação de Montanha (CIMO) / Mountain Research Center (CIMO)
UID/AGR/00690/2019
Instituto Politécnico de Bragança, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/10/01 - 2019/10/01 Bring natural colorants and preservers into a real alternative to artificial additives through a strategy of open data and experience based research
SAICT-POL/23289/2016
DeCodE
Instituto Politécnico de Viana do Castelo, Portugal

Instituto Politécnico de Bragança, Portugal

Instituto Politécnico de Bragança Centro de Investigação de Montanha, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017 - 2019 DeCodE - Bring natural colorants and preservers into a real alternative to artificial additives through a strategy of open data and experience based research
NORTE-01-0145-FEDER-023289
Researcher
Centro de Investigação de Montanha, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2014/05/01 - 2016/05/31 AROMAP: Preservation of aromatic condiment plants
53514
Researcher
Centro de Investigação de Montanha, Portugal
Concluded
2014/01/01 - 2015/12/31 PlantLact - New functional lactic products without synthetic conservatives
46577
Researcher
Centro de Investigação de Montanha, Portugal
Concluded
2010/12/24 - 2014/06/23 Novos compostos heterocíclicos antitumorais e anti-angiogénicos: síntese, modelação molecular, screennig de inibição enzimática e estudos em linhas celulares tumorais e endoteliais com receptores membranares de tirosina cinase como alvos.
PTDC/QUI-QUI/111060/2009
Researcher
Centro de Investigação de Montanha, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 690 - 2011-2012
PEst-OE/AGR/UI0690/2011
Instituto Politécnico de Bragança, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/12/24 - 2013/12/23 Cogumelos Silvestres Portugueses: Caracterização química e estudo funcional de propriedades antiproliferativas e proapoptóticas em linhas celulares cancerígenas
PTDC/AGR-ALI/110062/2009
Researcher
Centro de Investigação de Montanha, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2007/06/30 Propriedades bioactivas de cogumelos silvestres comestíveis
POCI/AGR/56661/2004
Centro de Investigação de Montanha, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2007 Estratégias para a minimização da Safra e contra safra do olival
743
Researcher
Instituto Politécnico de Bragança, Portugal
Concluded
2002/02/01 - 2005/07/31 Caracterização do Mel de Trás-os-Montes: Demonstração do Contributo do Meio Ambiente e da Acção dos Apicultores para a Qualidade do Produto
AGRO, projecto nº 242
Researcher
Instituto Politécnico de Bragança, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Calhelha, Ricardo C.; Shiraishi, Carlos Seiti Hurtado; Ribeiro, Lúcia Marisa Maia; Carocho, Márcio; Abreu, Rui M.V.; Coutinho, Paula; Barros, Lillian; et al. Corresponding author: Vaz, Josiana. "New trends from fungi secondary metabolism in the pharmaceutical industry". In Natural Secondary Metabolites, edited by Lillian Barros; Sandrina A. Heleno; Marcio Carocho. Switzerland: Springer Nature, 2023.
    10.1007/978-3-031-18587-8_26
  2. Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Metabolismo do sistema urinário: o rim como motor metabólico do sistema urinário". In Bioquímica Fisiológica: Integração do metabolismo na especialização dos orgãos, 235-247. Portugal: Edições Afrontamento, 2020.
    Published
  3. Alexandre Quintas; Carla Ascenso; Abreu, Rui M.V.; Carlos Família. "Estrutura e função de proteínas". In Bioquímica, organização molecular da vida, edited by Manuel J. Halpern; Alexandre Quintas; Ana Ponce. Lidel, 2008.
    Published
Conference abstract
  1. Shiraishi, C. S. H.; Yosra Zbiss; Custódio Lobo Roriz; Carocho, Marcio; Vasco da Cunha Mendes; Abreu, Rui M.V.; Prieto, Miguel A.; Heleno, Sandrina; Barros, Lillian. Corresponding author: Shiraishi, C. S. H.. "A chromatographic study offive varieties for its valorization". Paper presented in 12 EncontroNacional de Cromatografia, Aveiro, 2022.
    Published
  2. Yosra Zbiss; Shiraishi, C. S. H.; Custódio Lobo Roriz; Carocho, Marcio; Vasco da Cunha Mendes; Abreu, Rui M.V.; Sandrina A. Heleno; et al. Corresponding author: Sandrina A. Heleno. "Optimization of total phenolic content offig obtained through Response Surface Methodology". Paper presented in Innovation in Mediterranean Traditional Foods: novel products andprocesses, Bragnça, 2022.
  3. Shiraishi, C. S. H.; Prieto, Miguel A.; Barros, Lillian; Abreu, Rui M.V.. "Virtual screening of medicinal compounds present in mushrooms as potentialtyrosinase inhibitors". Paper presented in XVI Encontro de quimica dosalimentos, Castelo-Branco, 2022.
    Published
  4. Shiraishi, C. S. H.; Yosra Zbiss; Custódio Lobo Roriz; Abreu, Rui M.V.; Heleno, Sandrina; Miguel A. Prieto; Barros, Lillian. "Fig (Ficus carica L.) fruit bioresidues as sources of bioactive compounds for the food industry". Paper presented in 6 th International Symposium on Phytochemicals in Medicine and Food, Haangzhou, 2022.
    Published
  5. Cardoso, Rossana V.C.; Fernandes, Ângela; Barreira, João C.M.; Abreu, Rui M.V. (0F19-0DE2-12A2); Mandim, Filipa; Gonzaléz-Paramás, Ana M; Ferreira, Isabel C.F.R.; Barros, Lillian. "Optimization and recovery of Vitamin D2 from spurplus production of Agaricus bisporus Portobello". Paper presented in 1st Natural products application: health, cosmetic and food, bragança, 2021.
    Published
  6. Shiraishi, C. S. H.; Gonçalves, Odinei Hess; Abreu, Rui M.V.. Corresponding author: Shiraishi, C. S. H.. "In silico evaluation of a library of natural compoundsidentified in mushrooms as potential inhibitors of proteins associated to breastcancer: PPAR¿, aromatase, and 17-HSD1". Paper presented in 7thPortuguese young chemists meeting, Bragança, 2021.
    Published
  7. Añibarro-Ortega, Mikel; Rocha, Rosiane; José Pinela; Pires, T.C.S.P.; Abreu, Rui M.V.; Ana Luísa Saldanha; Alves, Maria José. "Red Raspberry waste as a source of anthocyanin-rich food colorants: extraction process optimization and functiobality assessment". Paper presented in Natural products application: Health, Cosmetic and Food, Bragança, 2021.
  8. Calhelha, Ricardo; Begouin, Agathe; Campos, Joana F.; Queiroz, Maria-João R. P.; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.. "Virtual screening of thieno[3,2-b]pyridine arylthioether (hetero)aryltriazole derivatives as potential tyrosine kinase VEGFR2 inhibitors.". Paper presented in Virtual screening of thieno[3,2-b]pyridine arylthioether (hetero)aryltriazole derivatives as potential tyrosine kinase VEGFR2 inhibitors., Vigo, 2013.
    Published
  9. Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Screening virtual e dinâmica molecular de compostos presentes em cogumelos com potencial inibidor de BCL2". Paper presented in 11º Encontro Nacional de Química dos Alimentos, Bragança, 2012.
    Published
Conference paper
  1. Pereira, Eliana; Caleja, Cristina; Sprea, Rafael M.; Abreu, Rui M.V.; Pires, Tânia C.S.; Amaral, Joana S.; Prieto Lage, Miguel A.; Barros, Lillian. "Basil and eucalyptus as a source of essential oils with bioactive properties". 2022.
  2. Shiraishi, C.S.H.; Souza, Sérgio F.; Prieto Lage, Miguel A.; Barros, Lillian; Abreu, Rui M.V.; Shiraishi, C. S. H.; Sousa, Sérgio F.; et al. "Virtual screening of a library of natural compounds against COX-2 protein". Paper presented in Encontro de Jovens investigadores do Insituto Politécnico de Bragança, 2022.
  3. Novais, Cláudia; Molina, Adriana K.; Abreu, Rui M.V.; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R.; Pereira, Carla; Barros, Lillian. "Bio-based hybrid molecules for coloring and preservative purposes". 2022.
  4. Aichouche, Chaimaa; Pereira, Eliana; Pinela, José; Heleno, Sandrina A.; Abreu, Rui M.V.; Noui, Abdallah; Ferreira, Isabel C.F.R.; Caleja, Cristina; Barros, Lillian. "Valorization of apple by-products into flour: nutritional and chemical characterization and evaluation of bioactive properties". 2022.
  5. Shiraishi, Carlos Seiti Hurtado; Zbiss, Yosra; Roriz, Custódio Lobo; Carocho, Márcio; Domingos, Sara; Calhelha, Ricardo C.; Alves, Maria José; et al. Corresponding author: Barros, Lillian. "FIG (Ficus Carica L.) Bioresidues as sources of bioactive compounds and natural pigments for the food industry". Paper presented in Trends in grain-based foods, Bragança, 2022.
  6. Cardoso, Rossana V.C.; Fernandes, Ângela; Abreu, Rui M.V.; Mandim, Filipa; González-Paramás, Ana María; Barros, Lillian; Cardoso, Rossana V. C. ; et al. "Bioactivity of the vitamin D2-enriched extract from surplus mushrooms". Paper presented in 1st International Congress on Food, Nutrition & Public Health, 2022.
  7. Oliveira, Izamara ; Heleno, Sandrina; Carocho, Marcio; Alves, Maria José; Abreu, Rui M.V.; Vaz, Josiana; Dias, Maria Inês; et al. "Comparison between different extraction methods in the recovery of bioactive molecules from Melissa officinalis L.under sustainable cultivation: chemical and bioactive characterization". Paper presented in The 2nd International Electronic Conference on Plant Sciences—10th Anniversary of Journal Plants, 2021.
    Published
  8. Sprea, Rafael M.; Pascoalino, Liege; Caleja, Cristina; Pereira, Eliana; Abreu, Rui M.V.; Pires, Tânia C.S.; Amaral, Joana S.; Prieto Lage, Miguel A.; Barros, Lillian. "Plants from Lamiaceae family as a source of essential oils with bioactive properties". 2021.
  9. Añibarro-Ortega, Mikel; Rocha, Rosiane; Pinela, José; Pires, Tânia C.S.; Abreu, Rui M.V.; Saldanha, Ana Luísa; Alves, Maria José; et al. "Red raspberry waste as a source of anthocyanin-rich food colorants: extraction process optimization and functionality assessment". 2021.
  10. Garcia, Jéssica A. A.; Corrêa, Rúbia Carvalho Gomes; Barros, Lillian; Pereira, Carla; Abreu, Rui M.V.; Alves, Maria José; Calhelha, Ricardo C.; et al. "Composição Química e Atividades Biológicas da Casca do Fruto da Palmeira Juçara (Euterpe edulis Martius)". Paper presented in VII Simpósio De Bioquímica E Biotecnologia ¿ SIMBBTEC, Londrina, 2019.
    Published
  11. Garcia, Jéssica A.A.; Corrêa, Rúbia Carvalho Gomes; Barros, Lillian; Pereira, Carla; Abreu, Rui M.V.; Alves, Maria José; Calhelha, Ricardo C.; et al. "Perfil fitoquímico e atividades biológicas das folhas de ¿Orapronóbis¿ (Pereskia aculeata Miller)". Paper presented in Simpósio De Bioquímica E Biotecnologia - SIMBBTEC, Londrina, 2019.
    Published
  12. Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Farnesoid X Receptor as a potential protein target for mushroom LMW compounds: virtual screening using molecular docking". 2017.
  13. Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Sousa, João N.; Amaro, José C.R.; Abreu, Rui M.V.. "VScore: uma plataforma para desenvolvimento de novos fármacos usando screening virtual". 2013.
  14. Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Valorização de cogumelos silvestres como alimentos funcionais: estudos de química computacional". 2011.
  15. Calhelha, Ricardo C.; Abreu, Rui M.V.; Vilas-Boas, Miguel; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.. "Chemical, biochemical and electrochemical assays to evaluate antioxidant properties of three new diarylamines in the thieno[3,2-b]pyridine series.". 2011.
  16. Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Adega, Filomena; Chaves, Raquel. "New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies". 2011.
  17. Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Docking studies using proteins involved in breast cancer and low molecular weight compounds found in wild mushrooms". 2010.
  18. Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Virtual ligand screening studies between mushroom compounds and proteins involved in breast cancer". 2010.
  19. Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Adega, Filomena; Chaves, Raquel. "Anti-proliferative activity of thieno[3,2-b]pyridine derivatives in tumoral and primary hepatic cell lines.". 2010.
  20. Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.. "QSAR studies on di(hetero)arylamines derivatives of benzo[b]thiophenes as free radical scavengers". 2008.
  21. Falcão, Soraia; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vilas-Boas, Miguel; Queiroz, Maria João R.P.. "Electrochemical evaluation of the redox-properties of diarylamines in the 2,3-dimethylbenzo[b]thiophene series". 2008.
  22. Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.. "Farnesoid X receptor: docking model validation". 2008.
Conference poster
  1. Reis, Filipa S.; Cardoso, Rossana V. C. ; Sprea, Rafael M.; Abreu, Rui M.V.; Francisco de la Peña; Manuel Román; Barros, Lillian. "UP4HEALTH INGREDIENTS: SPECIALITY PLANT-BASED FOOD PROCESSING BY-PRODUCT EXTRACTS FOR INDUSTRIAL APPLICATION". Paper presented in 4th International Conference on FOOD BIOACTIVES & HEALTH, 2023.
  2. Shiraishi, C. S. H.; Zbiss, Yosra; Custódio Lobo Roriz; Dias, Maria Inês; Carocho, Marcio; Vasco Cunha Mendes; Abreu, Rui M.V.. "Chromatographic profileof free sugars in fruits from five different varieties of Ficus carica L.". Paper presented in 12 Encontro Nacional de Cromatografia, 2022.
  3. Shiraishi, C. S. H.; Yosra Zbiss; Custódio Lobo Roriz; Dias, Maria Inês; Carocho, Marcio; Vasco da Cunha Mendes; Abreu, Rui M.V.. "Fig (Ficus carica L.)biowaste as sources of phenolic compounds for the food and pharmaceutical industry". Paper presented in 1st International Congress on Food,Nutrition and Public Health, 2022.
  4. Shiraishi, C. S. H.; Yosra Zbiss; Custódio Lobo Roriz; Dias, Maria Inês; Carocho, Marcio; Vasco da Cunha Mendes; Abreu, Rui M.V.. "Fig (Ficus carica L.) biowaste as a source of organic acids for the food industry". Paper presented in 1st International Congress on Food,Nutrition & Public Health, 2022.
  5. Shiraishi, C. S. H.; Prieto, Miguel A.; Abreu, Rui M.V.; Barros, Lillian. Corresponding author: Shiraishi, C. S. H.. "Synergistic aspects between biotechnologyand computer science". Paper presented in 5th Symposium onMedicinal Chemistry, 2022.
  6. Sprea, Rafael M.; Pascoalino, Liege A.; Caleja, Cristina; Pereira, Eliana; Abreu, Rui M.V. (0F19-0DE2-12A2); Pires, Tânia C.S.; Amaral, Joana S.; Prieto Lage, Miguel A.; Barros, Lillian. "Plants from Lamiaceae family as a source of essential oils with bioactive properties". Paper presented in XV Encontro de Química dos Alimentos, 2021.
  7. Núñez-Estévez, Bernabé; Finimundy, Tiane; Maria Carpena; Marta Barral-Martinez; Paz Otero; Tânia C.S.P. Pires; Abreu, Rui M.V.; et al. "Amaranthaceae family: a novel source of nutrients and bioactive compounds". Paper presented in 5th International Symposium on Phytochemicals in Medicine and Food (5-ISPMF), 2021.
  8. Pedrosa, Mariana C; Cláudia Rodrigues; Heleno, Sandrina; Carocho, Marcio; Abreu, Rui M.V.; Tânia Ribeiro; Manuela Machado; et al. "Extraction of bioactive compounds from plants as promising agentes against SARS-CoV-2". Paper presented in 4th International Congress of Bíochemistry and Microbiology Applied Technologie, 2021.
  9. Nermine Bersour; Yosra Chammakhi; Pinela, José; Mohamed Mezni; Caleja, Cristina; Carla Pereira; Abreu, Rui M.V.; et al. "Development of semi-solid formulations containing extracts of Juglans regia L. leaves for topical application". Paper presented in 7th Portuguese Young Chemists Meeting (PYCheM), 2021.
  10. Mateus, Cristiano G.S; Abreu, Rui M.V.. "Development of a QSAR model to evaluate the antioxidant activity of di(hetero)aryl compounds". Paper presented in Natural Products Application: Health, Cosmetic and Food online edition, 2021.
  11. Luís, Diogo P.; Adega, Filomena; Abreu, Rui M.V.. "Tyrosinase as a protein target for dermatological treatment". Paper presented in Natural Products Application: Health, Cosmetic and Food online edition, 2021.
  12. Pinheiral, José P.L; Adega, Filomena; Abreu, Rui M.V.. "In silico study of a library of flavonoids as potential collagenase inhibitors". Paper presented in Natural products application: Health, Cosmetic and Food, 2021.
  13. Sampaio, Luís C.M.; Adega, Filomena; Abreu, Rui M.V.. "Elastase and its potential as target protein for bioactive compounds". Paper presented in Natural Products Application: Health, Cosmetic and Food online edition, 2021.
  14. Añibarro-Ortega, Mikel; Rocha, Rosiane; Pinela, José; Abreu, Rui M.V. (0F19-0DE2-12A2); Saldanha, Ana Luísa; Alves, Maria José; Nogueira, António José M.; Ferreira, Isabel C.F.R.; Barros, Lillian. "Red raspberry waste as a source of anthocyanin-rich food colorants: extraction process optimization and functionality assessment". Paper presented in 1st Natural products application: health, cosmetic and food, 2021.
  15. Núñez-Estévez, Bernabé; Finimundy, Tiane; M. Carpena; Paz Otero; M. Barral-Martinez; Shiraishi, C. S. H.; Abreu, Rui M.V.. "Antimicrobial and cytotoxic activity of Amaranthaceae famyly extract:sourceof new antibiotics and anticancer treatments". Paper presented in 4th CINBIO Anual Meeting, 2021.
  16. Santos, Soraia; Luís, Diogo; Abreu, Rui M.V.; Adega, Filomena. Corresponding author: Santos, Soraia. "Molecular docking: applications in drug discovery". Paper presented in XII Jornadas de Genética e Biotecnologia/ II Jornadas Ibéricas de Genética y Biotecnología, 2020.
  17. Vieira, Vanessa; Pereira, Carla; Abreu, Rui M.V.; Calhelha, Ricardo; Alves, Maria José; Coutinho, Joao A. P.; Ferreira, Olga; Barros, Lillian; Ferreira, Isabel C.F.R.. "Phytochemical profile and bioactivity of walnut green husks". Paper presented in The 3rd International Symposium on Green Chemistry, 2019.
  18. Sabrine Khelifa; Hajkhelil, Amel; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.. "Investigating mushroom LMW compounds as potential Bcl-2 inhibitors: docking studies using AutoDock4". Paper presented in Les Septièmes Journées Scientifiques Internationales sur la Valorisation des Bioressources, 2016.
  19. Guimarães, Rafaela; Abreu, Rui M.V.; Calhelha, Ricardo; Froufe, Hugo J.C.; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.. "Inhibition of the VEGFR-2 tyrosine kinase domain by witd Roman chamomile extracts and phenolic compounds". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, 2015.
  20. Liberal, Ângela; Pereira, Carla; Calhelha, Ricardo; Abreu, Rui M.V.; Adega, Filomena; Ferreira, Isabel C.F.R.. "Antioxidant and anti-inflammatory properties of red, white and pink globe amaranth hydromethanolic extracts". Paper presented in 2nd Symposium on Medicinal Chemistry of University of Minho, 2015.
  21. Abreu, Rui M.V.; Oludemi, Taofiq; Calhelha, Ricardo; Heleno, Sandrina; Barros, Lillian; Martins, Anabela; Queiroz, Maria-João R. P.; Ferreira, Isabel C.F.R.. "Anti-inflammatory activity of mushrooms extracts, identified phenolic acids and their possible metabolites". Paper presented in III Encontro de Jovens Investigadores. Bragança, 2015.
  22. Quintas, Hélder; Sequeira, Ana; Coelho, Ana Cláudia; Abreu, Rui M.V.; Alegria, Nuno; Mendonça, Álvaro. "A amilóide A no leite é útil no diagnóstico de mastites subclínicas em caprinos?". Paper presented in I Congresso Nacional das Escolas Superiores Agrárias, 2015.
  23. Machado, Vera; Peixoto, Daniela; Raquel, Costa; Calhelha, Ricardo; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Soares, Raquel; Queiroz, Maria-João R. P.. "Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors". Paper presented in International Symposium of Medicinal Chemistry, 2014.
  24. Queiroz, Maria-João R. P.; Calhelha, Ricardo; Soares, Pedro; Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena. "New di(hetero)aryl)ethers and Di(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, growth inhibitory activity on tumor cell lines and non tumor cells, effects on cell cycle and on apoptosis". Paper presented in International Symposium of Medicinal Chemistry, 2014.
  25. Sequeira, Ana; Coelho, Ana Cláudia; Abreu, Rui M.V.; Alegria,Nuno; Mendonça, Álvaro; Quintas, Hélder. "Diagnóstico de mastite subclínica caprina pelo método do doseamento de Amilóide A no leite". Paper presented in OVICAPRI-Simpósio de Ovinos e Caprinos, 2014.
  26. Barreira, João C.M.; Abreu, Rui M.V.; Rodrigues, Sandra; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.. "Evaluation of growth inhibitory activity of Crataegus monogyna Jacq. flower bud extracts against human tumor cell lines". Paper presented in 1st Symposium on Medicinal Chemistry, 2013.
  27. Calhelha, Ricardo; Peixoto, Daniela; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.. "Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylthioethers in the thieno[3,2-b]pyridine series". Paper presented in 1st Symposium on Medicinal Chemistry, 2013.
  28. Machado, Vera A.; Costa, Raquel; Peixoto, Daniela; Abreu, Rui M.V.; Calhelha, Ricardo; Soares, Raquel; Queiroz, Maria-João R. P.. "New di(heteroaryl)thioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase inhibitors: docking, synthesis, enzymatic and cellular assays". Paper presented in 49th International Conference on Medicinal Chemistry (RICT 2013), Nice, 2013.
  29. Campos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.; Calhelha, Ricardo. "Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2". Paper presented in 1st Symposium on Medicinal Chemistry, 2013.
  30. Calhelha, Ricardo; Peixoto, Daniela; Soares, Pedro; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Queiroz, Maria-João R. P.. "Epidermal growth factor receptor inhibitory activity of new potential antitumor di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series". Paper presented in 1st International Symposium on Profiling, 2013.
  31. Queiroz, Maria-João R. P.; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M.V.; Froufe, Hugo J.C.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Costa, Raquel; Soares, Raquel. "Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays". Paper presented in 48th International conference on Medicinal Chemistry. Interfacing Chemical Biology and Drug Discovery, 2012.
  32. Calhelha, Ricardo; Peixoto, Daniela; Soares, Pedro; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Queiroz, Maria-João R. P.. "Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series.". Paper presented in 3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, 2012.
  33. Queiroz, Maria-João R. P.; Peixoto, Daniela; Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Calhelha, Ricardo; Ferreira, Isabel C.F.R.; Costa, Raquel; Soares, Raquel. "1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays". Paper presented in XXIInd International Symposium on Medicinal Chemistry, 2012.
  34. Calhelha, Ricardo; Peixoto, Daniela; Soares, Pedro; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.. "Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines". Paper presented in XXIInd International Symposium on Medicinal Chemistry, 2012.
  35. Peixoto, Daniela; Queiroz, Maria-João R. P.; Abreu, Rui M.V.; Calhelha, Ricardo; Ferreira, Isabel C.F.R.. "Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors". Paper presented in XXIInd International Symposium on Medicinal Chemistry, 2012.
  36. Abreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.. "Rational design of thieno[3,2-b]pyridines as potential new VEGFR-2 inhibitors based on improved docking scores.". Paper presented in XII Encontro Nacional da Sociedade Portuguesa de Química: 100 anos de Química em Portugal, 2011.
  37. Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Froufe, Hugo J.C.. "Mdm2 as a potential target for mushrooms LMW compounds.". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery, 2011.
  38. Peixoto, Daniela; Calhelha, Ricardo; Dias, Sofia; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P.. "Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery, 2011.
Journal article
  1. Leimann, Fernanda Vitória; Souza, Luma Borges de; Oliveira, Byanca Pereira Moreira de; Rossi, Bruna Franzon; Silva, Patricia Sabino da; Shiraishi, Carlos Seiti Hurtado; Kaplum, Vanessa; et al. "Evaluation of berberine nanoparticles as a strategy to modulate acetylcholinesterase activity". (2023): http://hdl.handle.net/10198/7873.
    10.1016/j.foodres.2023.113295
  2. Shiraishi, Carlos Seiti Hurtado; Zbiss, Yosra; Roriz, Custódio Lobo; Dias, Maria Inês; Prieto Lage, Miguel A.; Calhelha, Ricardo C.; Alves, Maria José; et al. "Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization". (2023): http://hdl.handle.net/10198/25894.
    10.3390/pr11041179
  3. Serrano, Carmo; Sapata, Margarida; Oliveira, M. Conceição; Soares, Andreia; Pereira, Carla; Abreu, Rui M.V.; Barros, Lillian. "Encapsulation of sorghum leaf red dye: biological and physicochemical properties and effect on stability". (2023): http://hdl.handle.net/10198/22397.
    10.3390/foods12081646
  4. Novais, Cláudia; Molina, Adriana K.; Abreu, Rui M.V.; Santo-Buelga, Celestino; Ferreira, Isabel C.F.R.; Pereira, Carla; Barros, Lillian; Abreu, Rui M. V.; Ferreira, Isabel C. F. R.. "Natural food colorants and preservatives: a review, a demand, and a challenge". Journal of Agricultural and Food Chemistry (2022): http://hdl.handle.net/10198/25208.
    Published • 10.1021/acs.jafc.1c07533
  5. Rodrigues, Maria João; Castañeda-Loaiza, Viana; Monteiro, Ivo; Pinela, José; Barros, Lillian; Abreu, Rui M. V.; Oliveira, Maria Conceição; et al. "Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives". Foods 10 12 (2021): 3104. http://dx.doi.org/10.3390/foods10123104.
    Open access • Published • 10.3390/foods10123104
  6. Cardoso, Rossana V. C.; Fernandes, Ângela; Barreira, João C. M.; Abreu, Rui M. V.; Mandim, Filipa; Gonzaléz-Paramás, Ana M.; Ferreira, Isabel C. F. R.; et al. "A Case Study on Surplus Mushrooms Production: Extraction and Recovery of Vitamin D2". Agriculture 11 7 (2021): 579. http://dx.doi.org/10.3390/agriculture11070579.
    Open access • Published • 10.3390/agriculture11070579
  7. de Oliveira, Anielle; Moreira, Thaysa Fernandes Moya; Pepinelli, Ana Luisa Silva; Costa, Luis Gustavo Médice Arabel; Leal, Luana Eloísa; da Silva, Tamires Barlati Vieira; Gonçalves, Odinei Hess; et al. "Bioactivity screening of pinhão (Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: the inhibition of cholinesterases and a-amylases, and cytotoxic and anti-inflammatory activities". Food & Function 12 20 (2021): 9820-9828. http://dx.doi.org/10.1039/d1fo01163d.
    Published • 10.1039/d1fo01163d
  8. Silva, Gabriel Figueiredo Pantuzza; Pereira, Eliana; Melgar Castañeda, Bruno; Stojkovic, Dejan; Sokovic, Marina; Calhelha, Ricardo C.; Pereira, Carla; et al. "Eggplant fruit (Solanum melongena l.) and bio-residues as a source of nutrients, bioactive compounds, and food colorants, using innovative food technologies". Applied Sciences (Switzerland) 11 1 (2021): 1-24. http://hdl.handle.net/10198/24283.
    Published • 10.3390/app11010151
  9. Albuquerque, Bianca R.; Pereira, Carla; Calhelha, Ricardo C.; José Alves, Maria; Abreu, Rui M.V.; Barros, Lillian; Oliveira, M. Beatriz P.P.; Ferreira, Isabel C.F.R.. "Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties". Food Chemistry 309 (2020): 125735. http://dx.doi.org/10.1016/j.foodchem.2019.125735.
    Open access • Published • 10.1016/j.foodchem.2019.125735
  10. Grella Miranda, Cristiane; dos Santos, Priscila Dayane Freitas; do Prado Silva, Jéssica Thaís; Vitória Leimann, Fernanda; Ferreira Borges, Bianca; Miguel Abreu, Rui; Porto Ineu, Rafael; Hess Gonçalves, Odinei. "Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations". Food Chemistry 307 (2020): 125523. http://dx.doi.org/10.1016/j.foodchem.2019.125523.
    Open access • Published • 10.1016/j.foodchem.2019.125523
  11. Vieira, Vanessa; Pereira, Carla; Abreu, Rui M.V.; Calhelha, Ricardo C.; Alves, Maria José; Coutinho, João A.P.; Ferreira, Olga; Barros, Lillian; Ferreira, Isabel C.F.R.. "Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals". Food and Chemical Toxicology 137 (2020): 111189. http://dx.doi.org/10.1016/j.fct.2020.111189.
    Open access • Published • 10.1016/j.fct.2020.111189
  12. Rocha, R.; Pinela, J.; Abreu, R.M.V.; Añibarro-Ortega, M.; Pires, T.C.S.P.; Saldanha, A.L.; Alves, M.J.; et al. "Extraction of anthocyanins from red raspberry for natural food colorants development: Processes optimization and in vitro bioactivity". Processes 8 11 (2020): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096054181&partnerID=MN8TOARS.
    Open access • Published • 10.3390/pr8111447
  13. Ziani, B.E.C.; Carocho, M.; Abreu, R.M.V.; Bachari, K.; Alves, M.J.; Calhelha, R.C.; Talhi, O.; Barros, L.; Ferreira, I.C.F.R.. "Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts". Food Bioscience 36 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083874548&partnerID=MN8TOARS.
    Open access • Published • 10.1016/j.fbio.2020.100616
  14. Palmeira, Luís; Pereira, Carla; Dias, Maria Inês; Abreu, Rui M.V.; Corrêa, Rúbia C.G.; Pires, Tânia C.S.P.; Alves, Maria José; Barros, Lillian; Ferreira, Isabel C.F.R.. "Nutritional, chemical and bioactive profiles of different parts of a Portuguese common fig (Ficus carica L.) variety". Food Research International 126 (2019): 108572. http://dx.doi.org/10.1016/j.foodres.2019.108572.
    Published • 10.1016/j.foodres.2019.108572
  15. Garcia, Jéssica A.A.; Corrêa, Rúbia C.G.; Barros, Lillian; Pereira, Carla; Abreu, Rui M.V.; Alves, Maria José; Calhelha, Ricardo C.; et al. "Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest". Food Chemistry 294 (2019): 302-308. http://dx.doi.org/10.1016/j.foodchem.2019.05.074.
    Published • 10.1016/j.foodchem.2019.05.074
  16. Garcia, Jéssica A.A.; Corrêa, Rúbia C.G.; Barros, Lillian; Pereira, Carla; Abreu, Rui M.V.; Alves, Maria José; Calhelha, Ricardo C.; et al. "Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds". Journal of Functional Foods 55 (2019): 325-332. http://dx.doi.org/10.1016/j.jff.2019.02.037.
    Published • 10.1016/j.jff.2019.02.037
  17. Lockowandt, Lara; Pinela, José; Roriz, Custódio Lobo; Pereira, Carla; Abreu, Rui M.V.; Calhelha, Ricardo C.; Alves, Maria José; et al. "Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part". Industrial Crops and Products 128 (2019): 496-503. http://dx.doi.org/10.1016/j.indcrop.2018.11.059.
    Published • 10.1016/j.indcrop.2018.11.059
  18. Mandim, Filipa; Barros, Lillian; Calhelha, Ricardo C.; Abreu, Rui M. V.; Pinela, José; Alves, Maria José; Heleno, Sandrina; Santos, P. F.; Ferreira, Isabel C. F. R.. "Calluna vulgaris (L.) Hull: chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota". Food & Function 10 1 (2019): 78-89. http://dx.doi.org/10.1039/c8fo01910j.
    Published • 10.1039/c8fo01910j
  19. Mosbah, Habib; Chahdoura, Hassiba; Mannai, Asma; Snoussi, Mejdi; Aouadi, Kaïss; Abreu, Rui M. V.; Bouslama, Ali; Achour, Lotfi; Selmi, Boulbaba. "Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies". Applied Biochemistry and Biotechnology 187 3 (2018): 1113-1130. http://dx.doi.org/10.1007/s12010-018-2868-2.
    Published • 10.1007/s12010-018-2868-2
  20. Finimundy, Tiane C.; Barros, Lillian; Calhelha, Ricardo C.; Alves, Maria José; Prieto, Miguel A.; Abreu, Rui M.V.; Dillon, Aldo J.P.; et al. "Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds". Food Chemistry 245 (2018): 150-158. http://dx.doi.org/10.1016/j.foodchem.2017.10.088.
    Open access • Published • 10.1016/j.foodchem.2017.10.088
  21. Ribeiro, Andreia; Abreu, Rui M.V.; Dias, Madalena M.; Barreiro, Maria Filomena; Ferreira, Isabel C.F.R.. "Antiangiogenic compounds: well-established drugs versus emerging natural molecules". Cancer Letters 415 (2018): 86-105. http://dx.doi.org/10.1016/j.canlet.2017.12.006.
    Published • 10.1016/j.canlet.2017.12.006
  22. Finimundy, Tiane C.; Abreu, Rui M.V.; Bonetto, Natalia; Scariot, Fernando J.; Dillon, Aldo J.P.; Echeverrigaray, Sergio; Barros, Lillian; et al. "Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines". Food and Chemical Toxicology 112 (2018): 383-392. http://dx.doi.org/10.1016/j.fct.2018.01.015.
    Published • 10.1016/j.fct.2018.01.015
  23. Oliveira, Franciely S.; Ribeiro, Andreia; Barros, Lillian; Calhelha, Ricardo C.; Barreira, João C.M.; Junior, Bogdan D.; Abreu, Rui M.V.; Barreiro, Maria Filomena; Ferreira, Isabel C.F.R.. "Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)". Journal of Functional Foods 38 (2017): 214-220. http://dx.doi.org/10.1016/j.jff.2017.09.027.
    Published • 10.1016/j.jff.2017.09.027
  24. Merski, Matthew; Moreira, Cátia; Abreu, Rui MV; Ramos, Maria João; Fernandes, Pedro A; Martins, L Miguel; Pereira, Pedro José Barbosa; Macedo-Ribeiro, Sandra. "Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2". Cell Death & Disease 8 10 (2017): e3119-e3119. http://dx.doi.org/10.1038/cddis.2017.487.
    Published • 10.1038/cddis.2017.487
  25. Rafaela Guimarães; Ricardo C. Calhelha; Hugo J. C. Froufe; Rui M. V. Abreu; Ana Maria Carvalho; Maria João; R. P. Queiroz; Isabel C. F. R. Ferreira. "Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase". Food Funct. 7 1 (2016): 79-83. https://doi.org/10.1039%2Fc5fo00586h.
    Published • 10.1039/c5fo00586h
  26. Ângela Liberal; Ricardo C. Calhelha; Carla Pereira; Filomena Adega; Lillian Barros; Montserrat Dueñas; Celestino Santos-Buelga; Rui M. V. Abreu; Isabel C. F. R. Ferreira. "A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: red, white, and pink". Food Funct. 7 2 (2016): 679-688. https://doi.org/10.1039%2Fc5fo01342a.
    Published • 10.1039/c5fo01342a
  27. Vera A. Machado; Daniela Peixoto; Raquel Costa; Hugo J.C. Froufe; Ricardo C. Calhelha; Rui M.V. Abreu; Isabel C.F.R. Ferreira; Raquel Soares; Maria-João R.P. Queiroz. "Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors". Bioorganic & Medicinal Chemistry 23 19 (2015): 6497-6509. https://doi.org/10.1016%2Fj.bmc.2015.08.010.
    Published • 10.1016/j.bmc.2015.08.010
  28. Maria Alves; Hugo Froufe; Ana Costa; Anabela Santos; Liliana Oliveira; Sara Osório; Rui Abreu; Manuela Pintado; Isabel Ferreira. "Docking Studies in Target Proteins Involved in Antibacterial Action Mechanisms: Extending the Knowledge on Standard Antibiotics to Antimicrobial Mushroom Compounds". Molecules 19 2 (2014): 1672-1684. https://doi.org/10.3390%2Fmolecules19021672.
    Published • 10.3390/molecules19021672
  29. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Lima, R.T.; Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2013.09.023
  30. Sara Santos; Cláudia S. Baptista; Rui M. V. Abreu; Estela Bastos; Irina Amorim; Ivo G. Gut; Fátima Gärtner; Raquel Chaves; Rajeev Samant. "ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA and Protein Low Expression Levels: A Model for erbB-2 Negative Human Breast Cancer". PLoS ONE 8 12 (2013): e83673-e83673. https://doi.org/10.1371%2Fjournal.pone.0083673.
    Open access • Published • 10.1371/journal.pone.0083673
  31. Froufe, H.J.C.; Abreu, R.M.V.; Ferreira, I.C.F.R.. "Virtual screening of low molecular weight mushrooms compounds as potential Mdm2 inhibitors". Journal of Enzyme Inhibition and Medicinal Chemistry 28 3 (2013): 569-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875395885&partnerID=MN8TOARS.
    Open access • Published • 10.3109/14756366.2012.658787
  32. Soares, P.; Costa, R.; Froufe, H.J.C.; Calhelha, R.C.; Peixoto, D.; Ferreira, I.C.F.R.; Abreu, R.M.V.; Soares, R.; Queiroz, M.-J.R.P.. "1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880883258&partnerID=MN8TOARS.
    Open access • Published • 10.1155/2013/154856
  33. Alves, M.J.; Ferreira, I.C.F.R.; Froufe, H.J.C.; Abreu, R.M.V.; Martins, A.; Pintado, M.. "Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies". Journal of Applied Microbiology 115 2 (2013): 346-357. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880594256&partnerID=MN8TOARS.
    Open access • Published • 10.1111/jam.12196
  34. Abreu, R.M.V.; Froufe, H.J.C.; Queiroz, M.-J.R.P.; Ferreira, I.C.F.R.. "Selective Flexibility of Side-Chain Residues Improves VEGFR-2 Docking Score using AutoDock Vina". Chemical Biology and Drug Design 79 4 (2012): 530-534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858796784&partnerID=MN8TOARS.
    Open access • Published • 10.1111/j.1747-0285.2011.01313.x
  35. Calhelha, R.C.; Ferreira, I.C.F.R.; Peixoto, D.; Abreu, R.M.V.; Vale-Silva, L.A.; Pinto, E.; Lima, R.T.; et al. "Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells". Molecules 17 4 (2012): 3834-3843. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860247243&partnerID=MN8TOARS.
    Open access • Published • 10.3390/molecules17043834
  36. Rodrigues, S.; Calhelha, R.C.; Barreira, J.C.M.; Dueñas, M.; Carvalho, A.M.; Abreu, R.M.V.; Santos-Buelga, C.; Ferreira, I.C.F.R.. "Crataegus monogyna buds and fruits phenolic extracts: Growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC-DAD-ESI/MS". Food Research International 49 1 (2012): 516-523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866284118&partnerID=MN8TOARS.
    Published • 10.1016/j.foodres.2012.07.046
  37. R.M.V. Abreu; H.J.C. Froufe; P.O.M. Daniel; M.J.R.P. Queiroz; I.C.F.R. Ferreira. "ChemT, an open-source software for building template-based chemical libraries". SAR and QSAR in Environmental Research 22 5-6 (2011): 603-610. https://doi.org/10.1080%2F1062936x.2011.604097.
    Published • 10.1080/1062936x.2011.604097
  38. Froufe, H.J.C.; Abreu, R.M.V.; Ferreira, I.C.F.R.. "QCAR models to predict wild mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition". Chemometrics and Intelligent Laboratory Systems 109 2 (2011): 192-196. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055066196&partnerID=MN8TOARS.
    Published • 10.1016/j.chemolab.2011.09.004
  39. Abreu, R.M.V.; Ferreira, I.C.F.R.; Calhelha, R.C.; Lima, R.T.; Vasconcelos, M.H.; Adega, F.; Chaves, R.; Queiroz, M.-J.R.P.. "Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies". European Journal of Medicinal Chemistry 46 12 (2011): 5800-5806. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955172000&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2011.09.029
  40. Froufe, H.J.C.; Abreu, R.M.V.; Ferreira, I.C.F.R.. "Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms". SAR and QSAR in Environmental Research 22 3-4 (2011): 315-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957869801&partnerID=MN8TOARS.
    Published • 10.1080/1062936X.2011.569897
  41. Abreu, R.M.V.; Froufe, H.J.C.; Queiroz, M.J.R.P.; Ferreira, I.C.F.R.. "MOLA: A bootable, self-configuring system for virtual screening using AutoDock4/Vina on computer clusters". Journal of Cheminformatics 2 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78649692457&partnerID=MN8TOARS.
    Published • 10.1186/1758-2946-2-10
  42. Abreu, R.; Falcão, S.; Calhelha, R.C.; Ferreira, I.C.F.R.; Queiroz, M.-J.R.P.; Vilas-Boas, M.. "Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile". Journal of Electroanalytical Chemistry 628 1-2 (2009): 43-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-61349185126&partnerID=MN8TOARS.
    Published • 10.1016/j.jelechem.2009.01.004
  43. Ferreira, I.C.F.R.; Barros, L.; Abreu, R.M.V.. "Antioxidants in wild mushrooms". Current Medicinal Chemistry 16 12 (2009): 1543-1560. http://www.scopus.com/inward/record.url?eid=2-s2.0-65649136222&partnerID=MN8TOARS.
    Open access • Published • 10.2174/092986709787909587
  44. Abreu, R.M.V.; Ferreira, I.C.F.R.; Queiroz, M.J.R.P.. "QSAR model for predicting radical scavenging activity of di(hetero)arylamines derivatives of benzo[b]thiophenes". European Journal of Medicinal Chemistry 44 5 (2009): 1952-1958. http://www.scopus.com/inward/record.url?eid=2-s2.0-62549113413&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2008.11.011
  45. Froufe, H.J.C.; Abreu, R.M.V.; Ferreira, I.C.F.R.. "A QCAR model for predicting antioxidant activity of wild mushrooms". SAR and QSAR in Environmental Research 20 5-6 (2009): 579-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-70649094241&partnerID=MN8TOARS.
    Published • 10.1080/10629360903408423
  46. Ferreira, I.C.F.R; Abreu, Rui M.V.. "Stress oxidativo, antioxidantes e fitoquímicos". Bioanálise 2 (2007): 32-39. https://bibliotecadigital.ipb.pt/handle/10198/2711.
    Published
  47. Abreu, R.M.V.; Santos, D.J.S.L.; Moreno, A.J.M.. "Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress". Journal of Pharmacology and Experimental Therapeutics 295 3 (2000): 1022-1030. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033681003&partnerID=MN8TOARS.
    Published
Thesis / Dissertation
  1. Mateus, Cristiano Gabi dos Santos. "QSAR modeling studies of a library of Human Tyrosinase inhibitors". Master, 2022. http://hdl.handle.net/10198/26453.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02/04 Anti-inflammatory evaluation of a lib. of natural compounds identified in mushrooms using in silico studies against COX enzymes Natural products application: Health, Cosmetic and Food
Centro de Investigação da Montanha (Bragança, Portugal)
2019 Chemical composition and bioactivities of Juçara fruit bio-residues, a promising source of valuable molecules XX EuroFoodChem Conference
(Porto, Portugal)
2019 Composition in anthocyanins and bioactive properties of jabuticaba bioresidues XX EuroFoodChem Conference
(Porto, Portugal)
2017 Farnesoid X Receptor as a potential protein target for mushroom LMW compounds: virtual screening using molecular docking 8es Journées Scientifiques Internationales sur la Valorisation des Bioressources
(Monastir, Tunisia)
2015 VScore: a software for management of large scale virtual screening projects in computer clusters Bioinformatics Open Days 2015, Universidade do Minho
(Braga, Portugal)
2013/05/14 Aplicação de ferramentas de quimioinformática no desenvolvimento de novos fármacos: tienopiridinas como inibidores de VEGFR-2 V Workshop em Bioinformática
(Bragança, Portugal)
2013 VScore: uma plataforma para desenvolvimento de novos fármacos usando screening virtual V Workshop em Bioinformática
(Bragança, Portugal)
2012 1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays 3º Encontro Nacional de Química Terapêutica e 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry
(aveiro, Portugal)
2011 ChemT and AutoDock MOLA Molecular Informatics Open Source Software Workshop
The Wellcome Trust (Cambridge, United Kingdom)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/08/01 - Current ScreenBeti: from virtual screening of natural compounds to anti-diabetic ingredients for the food industry
Co-supervisor
 Doutoramento em Tecnologia e Ciência Agro-Alimentar (PhD)
Universidade de Vigo Facultad de Ciencias, Spain
2021/01/01 - Current DUAL - Dual function hybrid molecules as the next generation of sustainable bio-based additive
Co-supervisor
 Doutoramento em Farmacia (PhD)
Universidad de Salamanca Facultad de Farmacia, Spain
2020/01/01 - Current Desenvolvimento de uma plataforma web dinâmica para visualização e análise de elementos transponíveis humanos: potenciais aplicações na investigação clínica e translacional
Co-supervisor
 Genética Molecular Comparativa e Tecnológica (PhD)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/12/16 - 2022/12/02 QSAR modeling studies of a library of Human Tyrosinase inhibitors
Supervisor of Cristiano Gabi dos Santos Mateus
 Engenharia Biotecnológica (Master)
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
2020 - 2021/11/01 Estudo do potencial anti-inflamatório de uma biblioteca de compostos naturais de cogumelos por screening virtual contra enzimas COX (-1 e -2)
Co-supervisor
 Mestrado em Qualidade e Segurança Alimentar (Master)
Instituto Politécnico de Bragança, Portugal
2021/05/01 - 2021/07/15 Implementação de uma metodologia para o estudo da bioacessibilidade de compostos fenólicos em amostras biológicas
Co-supervisor of Joana Sofia Pires Baptista
 Biologia e Biotecnologia (Degree)
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
2021/03/01 - 2021/06/30 Tirosinase humana como proteína-alvo para doenças de pele: estudos de modelação molecular
Co-supervisor of Nanci Morgana Fonseca Oliveira
 Biologia (Degree)
Universidade de Trás-os-Montes e Alto Douro Centro de Estudos em Letras, Portugal
2020/03/01 - 2020/10/31 Elastase as a protein target for bioactive compounds
Co-supervisor
 Genética e Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/03/01 - 2020/10/31 Tyrosinase as a protein target for skin ageing delay
Co-supervisor
 Genética e Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/03/01 - 2020/10/30 Estudo in silico de uma biblioteca de flavonoides como potenciais inibidores da colagenase
Co-supervisor
 Biologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/06/01 - 2020/07/31 Desenvolvimento de um modelo QSAR de avaliação da atividade antioxidante de derivados de di(hetero)arilaminas
Co-supervisor of Cristiano Mateus
 Biologia e Biotecnologia (Degree)
Instituto Politécnico de Bragança, Portugal
2017/03/01 - 2017/11/30 Virtual screening of a library of natural compounds against COX family of anti-inflammatory proteinl screening of a library of natural compounds against COX family of anti-inflammatory protein
Co-supervisor
 Qualidade e Segurança Alimentar (Master)
Instituto Politécnico de Bragança, Portugal
2016 - 2016 Low molecular weight compounds from mushrooms as potential Bcl-2 inhibitors: docking and virtual screening studies
Co-supervisor
 Engenharia Biotecnológica (Master)
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal
2009 - 2009 Valorisation of wild mushrooms as functional foods: chemoinformatic studies
Co-supervisor
 Qualidade e Segurança Alimentar (Master)
Instituto Politécnico de Bragança Escola Superior Agrária, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2013/05/15 - 2013/05/16 Workshop de Bioinformática Venha conhecer e compreender as aplicações e implicações da bioinformática (2013/05/15 - 2013/05/16)
Workshop (Co-organisor)
 Instituto Politécnico de Bragança Escola Superior Agrária, Portugal

Committee member

Activity description
Role 		Institution / Organization
2021/11/01 - Current Diretor do Mestrado em Engenharia Biotecnológica
Director
 Instituto Politécnico de Bragança, Portugal
2021/02/04 - 2021/02/05 Membro da comissão científica do congresso "Natural Products Application: Health, Cosmetic and Food
Member
 Centro de Investigação de Montanha, Portugal