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I have developed my research in the field of Hemato-Oncology, firstly, in the context of T-cell Acute Lymphoblastic Leukemia, as a PhD student at the Instituto de Medicina Molecular - João Lobo Antunes (concluded in 2011) under the supervision of Prof. João Barata. Next, I moved to the Instituto Português de Oncologia de Lisboa ¿ Francisco Gentil E.P.E to work with Prof. António Almeida in the context of Myeloproliferative Neoplasms. After four years in the Myeloid field I returned to Prof. João Barata laboratory and identified a new potential oncogene in T-cell Acute Lymphoblastic Leukemia (T-ALL). Currently, established as an independent researcher, my aim is to understand what drives leukemia growth and thriving is crucial to fight these diseases. Despite the recent advances in understanding the pathophysiology of several myeloid malignancies, treatment options remain highly limited and are not curative for most of these patients. My main goal is to uncover disease biology and use such discoveries to design novel, or, repurpose other therapeutic regiments that maximize treatment efficacy while minimize the severe side effects associated with the standard chemotherapy.
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Identification

Personal identification

Full name
Bruno António Caetano Cardoso

Citation names

  • Cardoso, Bruno A.

Author identifiers

Ciência ID
0F1A-378B-1157
ORCID iD
0000-0002-6521-7257
Scopus Author Id
24402845200

Email addresses

  • bacardoso@ucp.pt (Professional)
  • bacardoso@ucp.pt (Professional)

Addresses

  • Faculdade de Medicina da Universidade Católica Portuguesa - Campus de Sintra, Estrada Octávio Pato, 2635-631, Rio de Mouro, Sintra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2006/01/01 - 2011/12/20
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Ciências Morfológicas
Faculdade de Medicina da Universidade de Lisboa, Portugal
"IL-4 and TAL1 in T-cell acute lymphoblastic leukemia: studies on the participation of microenvironmental cues and cell-autonomous alterations in leukemogenesis" (THESIS/DISSERTATION)
2000/09/26 - 2005/10/06
Concluded
 Biologia Microbiana e Genética (Licenciatura)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
"Clonagem dos genes Tal1 e Lmo2 num vector lentiviral para transdução de células T precursoras primárias" (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2021/09/01 - Current Principal Investigator (Research) Universidade Católica Portuguesa, Portugal
Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde, Portugal
2018/08/01 - 2021/08/31 Researcher (Research) Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2016/09/01 - 2018/07/31 Postdoc (Research) Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2013/09/01 - 2016/08/31 Postdoc (Research) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
2012/02/01 - 2012/08/31 Postdoc (Research) Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
2006/01/01 - 2011/12/20 Research Trainee (Research) Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal
Instituto de Medicina Molecular - João Lobo Antunes (iMM-JLA), Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/09/01 - Current Assistant Professor (University Teacher) Universidade Católica Portuguesa, Portugal
Universidade Católica Portuguesa Campus Sintra, Portugal
Projects

Grant

Designation Funders
2022/07/01 - 2023/12/31 Saliva from Patients with cancer: searching for novel prognostic markers in Acute Myeloid Leukemia (SPIT-it-AML).
NA
Principal investigator
Universidade Católica Portuguesa Campus Sintra, Portugal
 Universidade Católica Portuguesa Centro de Investigação Interdisciplinar em Saúde Centro Regional de Viseu
Ongoing

Contract

Designation Funders
2018/06/01 - Current CIRCA-TO-TREAT-LEUKEMIA - Decoding the interplay between CK2, PI3K and the circadian molecular clock to better understand the biology of, and maximize targeted treatment responses in, T-cell leukemia
PTDC/MEC-HEM/31588/2017
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01 - 2023/06 The Reciprocal regulation between the circadian molecular clock and IL7/IL7R-mediated signalling in T-cell Acute Lymphoblastic Leukemia
EXPL/MEC-HEM/0571/2021
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Bruno A. Cardoso; Mafalda Duque; Ana Gírio; Rita Fragoso; Mariana L. Oliveira; James R. Allen; Leila R. Martins; et al. "CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia". Haematologica (2023): http://dx.doi.org/10.3324/haematol.2023.282854.
    10.3324/haematol.2023.282854
  2. "Center for Interdisciplinary Research in Health (CIIS) National Meeting 2023". BMC Proceedings (2023): http://dx.doi.org/10.1186/s12919-023-00269-8.
    10.1186/s12919-023-00269-8
  3. Cardoso, Bruno A.. "The Bone Marrow Niche - The Tumor Microenvironment That Ensures Leukemia Progression.". Advances in experimental medicine and biology (2020): https://doi.org/10.1007/978-3-030-34025-4_14.
    10.1007/978-3-030-34025-4_14
  4. Cardoso, B.A.; Ramos, T.L.; Belo, H.; Vilas-Boas, F.; Real, C.; Almeida, A.M.. "Vorinostat synergizes with antioxidant therapy to target myeloproliferative neoplasms". Experimental Hematology 72 (2019): 60-71.e11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062807790&partnerID=MN8TOARS.
    10.1016/j.exphem.2019.02.002
  5. Lopes-Coelho, F.; Silva, F.; Hipólito, A.; Cardoso, B.A.; Serpa, J.. "Acetylation drives hepatocyte nuclear factor 1ß stability by blocking proteasome-mediated degradation". Journal of Cellular Biochemistry 120 6 (2019): 9337-9344. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058038927&partnerID=MN8TOARS.
    10.1002/jcb.28209
  6. Daniel Ribeiro; Alice Melão; Ruben van Boxtel; Cristina I. Santos; Ana Silva; Milene C. Silva; Bruno A. Cardoso; Paul J. Coffer; João T. Barata. "STAT5 is essential for IL-7–mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells". Blood Advances 2 17 (2018): 2199-2213. https://doi.org/10.1182/bloodadvances.2018021063.
    10.1182/bloodadvances.2018021063
  7. Faria, M.; Matos, P.; Pereira, T.; Cabrera, R.; Cardoso, B.A.; Bugalho, M.J.; Silva, A.L.. "RAC1b overexpression stimulates proliferation and NF-¿B-mediated antiapoptotic signaling in thyroid cancer cells". PLoS ONE 12 2 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85013911616&partnerID=MN8TOARS.
    10.1371/journal.pone.0172689
  8. Oliveira, M.L.; Akkapeddi, P.; Alcobia, I.; Almeida, A.R.; Cardoso, B.A.; Fragoso, R.; Serafim, T.L.; Barata, J.T.. "From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia". Cellular Signalling 38 (2017): 10-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021247666&partnerID=MN8TOARS.
    10.1016/j.cellsig.2017.06.011
  9. Melão, A.; Spit, M.; Cardoso, B.A.; Barata, J.T.. "Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of t-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity". Haematologica 101 11 (2016): 1368-1379. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994667733&partnerID=MN8TOARS.
    10.3324/haematol.2015.141143
  10. Fleskens, V.; Mokry, M.; Van Der Leun, A.M.; Huppelschoten, S.; Pals, C.E.G.M.; Peeters, J.; Coenen, S.; et al. "FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2". Oncogene 35 31 (2016): 4141-4148. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951325829&partnerID=MN8TOARS.
    10.1038/onc.2015.481
  11. Silveira, A.B.; Laranjeira, A.B.A.; Rodrigues, G.O.L.; Leal, P.C.; Cardoso, B.A.; Barata, J.T.; Yunes, R.A.; et al. "PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia". Oncotarget 6 15 (2015): 13105-13118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931035628&partnerID=MN8TOARS.
  12. Belo, H.; Silva, G.; Cardoso, B.A.; Porto, B.; Minguillon, J.; Barbot, J.; Coutinho, J.; et al. "Epigenetic Alterations in Fanconi anaemia: Role in pathophysiology and therapeutic potential". PLoS ONE 10 10 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949034122&partnerID=MN8TOARS.
    10.1371/journal.pone.0139740
  13. Cardoso, B.A.; Belo, H.; Barata, J.T.; Almeida, A.M.. "The bone marrow-mediated protection of myeloproliferative neoplastic cells to vorinostat and ruxolitinib relies on the activation of JNK and PI3K Signalling Pathways". PLoS ONE 10 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84957108370&partnerID=MN8TOARS.
    10.1371/journal.pone.0143897
  14. Martins, L.R.; Lúcio, P.; Melão, A.; Antunes, I.; Cardoso, B.A.; Stansfield, R.; Bertilaccio, M.T.S.; et al. "Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia". Leukemia 28 1 (2014): 179-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891855786&partnerID=MN8TOARS.
    10.1038/leu.2013.232
  15. Silva, G.; Cardoso, B.A.; Belo, H.; Almeida, A.M.. "Vorinostat Induces Apoptosis and Differentiation in Myeloid Malignancies: Genetic and Molecular Mechanisms". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872172430&partnerID=MN8TOARS.
    10.1371/journal.pone.0053766
  16. Cardoso, B.A.; De Almeida, S.F.; Laranjeira, A.B.A.; Carmo-Fonseca, M.; Yunes, J.A.; Coffer, P.J.; Barata, J.T.. "TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells". Leukemia 25 10 (2011): 1578-1586. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054032532&partnerID=MN8TOARS.
    10.1038/leu.2011.140
  17. Zenatti, P.P.; Ribeiro, D.; Li, W.; Zuurbier, L.; Silva, M.C.; Paganin, M.; Tritapoe, J.; et al. "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nature Genetics 43 10 (2011): 932-941. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053385665&partnerID=MN8TOARS.
    10.1038/ng.924
  18. Silva, A.; Laranjeira, A.B.A.; Martins, L.R.; Cardoso, B.A.; Demengeot, J.; Andrés Yunes, J.; Seddon, B.; Barata, J.T.. "IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias". Cancer Research 71 14 (2011): 4780-4789. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960414811&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-10-3606
  19. Correia, D.V.; D'Orey, F.; Cardoso, B.A.; Lança, T.; Grosso, A.R.; DeBarros, A.; Martins, L.R.; Barata, J.T.; Silva-Santos, B.. "Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human ¿d T-cells". PLoS ONE 4 5 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-66249119050&partnerID=MN8TOARS.
    10.1371/journal.pone.0005657
  20. Cardoso, B.A.; Martins, L.R.; Santos, C.I.; Nadler, L.M.; Boussiotis, V.A.; Cardoso, A.A.; Barata, J.T.. "Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling". Leukemia 23 1 (2009): 206-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-58249103272&partnerID=MN8TOARS.
    10.1038/leu.2008.178
  21. Cardoso, B.A.; Gírio, A.; Henriques, C.; Martins, L.R.; Santos, C.; Silva, A.; Barata, J.T.. "Aberrant signaling in T-cell acute lymphoblastic leukemia: Biological and therapeutic implications". Brazilian Journal of Medical and Biological Research 41 5 (2008): 344-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-48249150799&partnerID=MN8TOARS.
  22. Silva, A.; Yunes, J.A.; Cardoso, B.A.; Martins, L.R.; Jotta, P.Y.; Abecasis, M.; Nowill, A.E.; et al. "PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability". Journal of Clinical Investigation 118 11 (2008): 3762-3774. http://www.scopus.com/inward/record.url?eid=2-s2.0-55849138418&partnerID=MN8TOARS.
    10.1172/JCI34616
Thesis / Dissertation
  1. Cardoso, Bruno António Caetano, 1982-. "IL-4 and TAL1 in T-cell acute lymphoblastic leukemia : studies on the participation of microenvironmental cues and cell-autonomous alterations in leukemogenesis". PhD, 2011. http://hdl.handle.net/10451/4846.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/05 CASZ1 Is Overexpressed in T-Cell Acute Lymphoblastic Leukemia and Promotes Cell Transformation Via PI3K-Akt-mTOR Signaling. Bruno A. Cardoso, Rita Fragoso, Ana Gírio, Leila R. Martins, Ana Sofia Moreira, Nádia Correia, Ana Rita Grosso, Sérgio F. de Almeida, J. Andres Yunes, Françoise Pflumio and João Barata (Poster presentation) International Conference on Acute Lymphoblastic Leukaemia,
(Berlin, Germany)
2018/12 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation via PI3K-Akt-mTOR signaling. Bruno A. Cardoso*, Ana Gírio*, Rita Fragoso*, Leila R. Martins, Ana Sofia Moreira, Nádia C. Correia, André Bortolini, Ana R. Grosso, Sérgio F. de Almeida, J. Andres Yunes, Françoise Pflumio and João T. Barata (Poster presentation) Symposia on Tumour Biology: from basic biology to disease
(Lisbon, Portugal)
2018/05/11 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation and tumor growth via PI3K-mTOR. Bruno A. Cardoso*, Ana Gírio*, Rita Fragoso*, Leila R. Martins, Ana S. Moreira, Nádia C. Correia, Ângelo Bortolini, Ana R. Grosso, Sérgio F. Almeida, Jose Yunes, Françoise Pflumio and João T. Barata. - Best Oral Presentation 3rd ASPIC International Congress
Associação Portuguesa de Investigação em Cancro (Lisboa, Portugal)
2017/06/01 CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation via MEK/Erk and PI3K signaling. Ana Gírio*, Bruno A. Cardoso*, Rita Fragoso, Leila R. Martins, Nádia C. Correia, A.R. Grosso, André Bortolini, J. Andres Yunes, Françoise Pflumio and João T. Barata 8th National meeting of Signal Transduction at Pavilhão do Conhecimento
Signal Transduction (SINAL) (Lisboa, Portugal)
2017/06 Targeting Chromatin Modifications in Hematological Malignancies - therapeutical applications. Bruno A. Cardoso, Hélio Belo and António M. Almeida Molecular Aspects of Hematological Disorders” – Pre-Congress Meeting - EHA 22nd Congress
European Hematology Association (Madrid, Spain)
2016/06 HDAC INHIBITION SYNERGIZES WITH ANTIOXIDANT THERAPY TO TARGET MYELOPROLIFERATIVE NEOPLASMS. Bruno António Cardoso, Teresa L Ramos, Hélio Belo, Filipe Vilas-Boas, Carla Real and António M. Almeida (Poster presentation) 21th Congress of the European Hematology Association (EHA)
(Copenhagen, Denmark)
2016/04 HDAC inhibition synergizes with Antioxidant therapy to target Myeloproliferative Neoplasms. Bruno A Cardoso, Teresa L Ramos, Hélio Belo, Filipe Vilas-Boas, Carla Real and António M. Almeida (Poster presentation) 2nd ASPIC International Congress
(Porto, Portugal)
2015/06 BONE MARROW STROMA MEDIATED PROTECTION OF MPN CELLS FROM RUXOLITINIB- AND VORINOSTAT-INDUCED APOPTOSIS REQUIRES MAPK-JNK AND PI3K-AKT/PKB SIGNALING PATHWAY ACTIVATION. Bruno A. Cardoso , Helio Belo , Joao Barata and Antonio Almeida (Poster presentation) 20th Congress of the European Hematology Association (EHA)
(Vienna, Austria)
2014/12 Bone Marrow Stroma Protects BCR-ABL-Negative Myeloproliferative Neoplasms from Ruxolitinib- and Vorinostat-Induced Apoptosis. Bruno A. Cardoso, Hélio Belo, João T. Barata and António M. Almeida (Poster presentation) 56th ASH (American Society of Hematology) Annual meeting and Exposition
(San Francisco, United States)
2014/12 Vorinostat Impairs Cellular Viability, Differentiation, Redox Homeostasis and Gene Expression in BCR-ABL-Negative Myeloproliferative Neoplasms. Bruno A. Cardoso, Hélio Belo, and António M. Almeida (Poster presentation) 56th ASH (American Society of Hematology) Annual meeting and Exposition
(San Francisco, United States)
2014/11/21 O ESTROMA MEDULAR PROTEGE CÉLULAS DE NEOPLASIAS MIELOPROLIFERATIVAS CRÓNICAS BCR-ABL-NEGATIVAS DOS EFEITOS CITOTÓXICOS INDUZIDOS POR RUXOLITINIB E VORINOSTAT. Bruno A. Cardoso, Hélio Belo e António M. Almeida 2014 Annual meeting of Portuguese Society of Hematology
Sociedade Portuguesa de Hematologia (Évora, Portugal)
2014/11/21 O IMPACTO DO VORINOSTAT NA VIABILIDADE CELULAR, DIFERENCIAÇÃO, HOMEOSTASIA REDOX E EXPRESSÃO GENÉTICA EM NEOPLASIAS MIELOPROLIFERATIVAS CRÓNICAS BCR-ABL-NEGATIVAS. Bruno A. Cardoso, Hélio Belo e António M. Almeida 2014 Annual meeting of Portuguese Society of Hematology
Sociedade Portuguesa de Hematologia (Évora, Portugal)
2014/11 Bone Marrow protects BCR-ABL-Negative Myeloproliferative Neoplasms from Ruxolitinib- and Vorinostat-Induced Apoptosis. Bruno A Cardoso, Hélio Belo, João T. Barata and António M. Almeida (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2014 Vorinostat Impairs Cellular Viability, Differentiation, Redox Homeostasis and Gene Expression in BCR-ABL-Negative MPN. Bruno A Cardoso, Hélio Belo and António M. Almeida (Poster presentation) 1st ASPIC International Congress
(Lisbon, Portugal)
2010/12/16 The TAL1/SCL oncogene is down-regulated by Histone Deacetylase inhibitors in T-cell Acute Lymphoblastic Leukemia. Bruno A. Cardoso, S. de Almeida, A. Laranjeira, M. Carmo-Fonseca, J.A. Yunes, P.J. Coffer and J.T. Barata. XVII National Congress on Biochemistry
Sociedade Portuguesa de Bioquímica (Porto, Portugal)
2010/05 Tal1/SCL is downregulated upon HDAC inhibition in T cell leukemia. B.A. Cardoso, Sérgio de Almeida, Angelo Laranjeira, J. Andres Yunes, Paul J. Coffer, João T. Barata (Poster presentation) SINAL 2010 – 4th National Meeting of Signal Transduction
(Faro, Portugal)
2009/05 HDAC Inhibitors in T-ALL: Is Tal1 important? B.A. Cardoso, Paul J. Coffer, João T. Barata (Poster presentation) SINAL 2009 – 3rd National Meeting of Signal Transduction
(Aveiro, Portugal)
2008/05 Interleukin-4 Stimulates Proliferation and Growth of T-Cell Acute Lymphoblastic Leukemia Cells by Activating mTOR Signaling. B.A. Cardoso, L.R. Martins, C. Santos, L.M. Nadler, V.A. Boussiotis, A.A. Cardoso, J.T. Barata (Poster presentation) SINAL 2008 – 2nd National Meeting of Signal Transduction
(Porto, Portugal)
2007/03 TAL1 and LMO2 in T-cell Acute Lymphoblastic Leukemia: Origin or consequence? B.A. Cardoso, J. Gonçalves, J.T. Barata (Poster presentation) SINAL – 1st National Meeting on Signal Transduction
(Lisbon, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09/01 - Current Circadian Molecular Clock in Myeloid Malignancies a novel therapeutic window?
Supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/01 - Current Understanding the importance of Death receptors in the therapeutic resistance of Myeloproliferative Neoplasms
Supervisor
 Mestrado em Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/09 - Current Coordinator and contact point for the Católica Medical Seminars (CMS), the scientific seminar series that occur monthly at the Católica Medical School since September 2022. (2022/09)
Seminar (President of the Organising Committee)
 Universidade Católica Portuguesa Campus Sintra, Portugal
2019/11 - 2019/11 Member of the Organizing Committee of the Pediatric Cancer Research: Where are we? What’s in the future? – ASPIC Conference that was held at the Fundação Calouste Gulbenkian, Lisbon, Portugal. (2019/11 - 2019/11)
Conference (Member of the Organising Committee)
2019/02 - 2019/02 Member of the Organizing committee of the Instituto de Medicina Molecular – João Lobo Antunes (iMM-JLA) Post-Doc day that was held at the iMM-JLA, Lisbon, Portugal. (2019/02 - 2019/02)
Conference (Member of the Organising Committee)
2015/05 - 2015/05 Member of the Organizing Committee responsible for the organization of the iNOVA4Health Kick-Off Meeting at “Instituto Português de Oncologia de Lisboa – Francisco Gentil (IPOL-FG)”, Lisbon, Portugal. (2015/05 - 2015/05)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/03/31 - 2023/04/01 CIIS National Meeting – Interdisciplinary Health Care, Católica Medical School, Sintra, Portugal.
Conference
2022/11/11 - 2022/11/12 2022 Annual meeting of Portuguese Society of Hematology at Troia Design Hotel, Troia, Portugal
Conference
2022/06/30 - 2022/07/01 5th ASPIC International Congress at “Instituto Português de Oncologia do Porto – Francisco Gentil”, Oporto, Portugal.
Congress
2022/05/12 - 2022/05/15 9th ESH meeting on Myeloproliferative Neoplasms (Online format)
Conference
2022/03/10 - 2022/03/13 3rd How to Diagnose and Treat Acute Leukaemias (Online format).
Conference
2021/06/30 - 2021/06/30 Encontro com a Ciência 2021, Centro de Congressos, Lisbon, Portugal
Conference
2021/05/07 - 2021/05/09 2nd Translational Research E-Conference on Acute Lymphoblastic Leukaemia (Online format).
Congress
2020/11 - 2020/11 Congento Course on Modules 9, 10, 11 - Upgrade to function B on Laboratory Animal Science
Workshop
 CONGENTO Course on Modules 9, 10 and 11
Fundação Champalimaud, Portugal
2020/03 - 2020/03 EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment, Centro de Congressos de Lisboa, Lisbon, Portugal.
Conference
2019/11 - 2019/11 Pediatric Cancer Research: Where are we? What’s in the future? – ASPIC Conference, Fundação Calouste Gulbenkian, Lisbon, Portugal.
Conference
2019/10 - 2019/10 5th International Conference Acute Myeloid Leukemia "Molecular and Translation": Advances in Biology and Treatment, Centro de Congresso do Estoril, Estoril, Portugal.
Conference
2019/06 - 2019/06 SHE Summer Course – “PBL and Beyond: Applying student centered learning principles in your education”. Maastricht University – School of Health Professions Education, Maastricht, The Netherlands.
Workshop
2019/05 - 2019/05 Workshop “Introduction in principles of PBL and tutoring/teaching skills” – by Faculty of Health, Medicine and Life Sciences (FHML) – Maastricht University. Universidade Católica Portuguesa, Campus da Palma de Cima, Lisbon, Portugal.
Workshop
2019/05 - 2019/05 International Conference on Acute Lymphoblastic Leukaemia, Vienna House Andel’s Berlin, Berlin, Germany.
Conference
2018/12 - 2018/12 Symposia on Tumour Biology: from basic biology to disease, Pestana Palace, Lisbon, Portugal.
Symposium
2018/09 - 2018/09 9th National meeting of Signal Transduction, Teatro Thalia, Lisbon, Portugal.
Meeting
2018/05 - 2018/05 3rd ASPIC International Congress at “Fundação Calouste Gulbenkian”, Lisbon, Portugal.
Congress
2018/02 - 2018/02 Entry Level Bioinformatics (ELB18F), entry level course with soft introduction to NGS data analysis. Instituto Gulbenkian Ciência, Oeiras, Portugal.
Workshop
2017/09 - 2017/09 Laboratory Animal Science 2017 –for functions a), c) and d) for rodents and fish (total duration 43h).
Workshop
2017/06 - 2017/06 8th National meeting of Signal Transduction at Pavilhão do Conhecimento, Lisbon, Portugal.
Meeting
2017/06 - 2017/06 “Molecular Aspects of Hematological Disorders” – Pre-Congress Meeting - EHA 22nd Congress at Feria de Madrid (IFEMA), Madrid, Spain.
Meeting
2017/06 - 2017/06 22nd European Hematology Association Congress at Feira de Madrid (IFEMA), Madrid, Spain.
Congress
2016/06 - 2016/07 1st CEDOC Symposium on Chronic Diseases at NOVA Medical School, Lisbon, Portugal.
Symposium
2016/04 - 2016/04 “Jornadas - Investigação em Oncologia em Portugal”.- Portuguese League Against Cancer – South Regional Branch, “Instituto Português de Oncologia de Lisboa – Francisco Gentil”, Lisbon, Portugal.
Conference
2016/04 - 2016/04 2nd ASPIC International Congress at “Instituto Português de Oncologia do Porto – Francisco Gentil”, Oporto, Portugal.
Congress
2015/05 - 2015/05 International Conference on The Tumour Microenvironment in the Haematological Malignancies and its Therapeutical Targeting – European School of Haematology at Hotel Marriott, Lisbon, Portugal.
Conference
2014/12 - 2014/12 56th ASH (American Society of Hematology) Annual meeting and Exposition, Moscone Center, San Francisco, California, United States of America.
Congress
2014/11 - 2014/11 2014 Annual meeting of Portuguese Society of Hematology at Évorahotel, Evora, Portugal.
Meeting
2014/11 - 2014/11 1st ASPIC International Congress at “Fundação Calouste Gulbenkian”, Lisbon, Portugal.
Congress
2014/10 - 2014/10 V- Franco-Iberian – CML Exchange Meeting, BMS CML Summit, Lisbon, Portugal
Meeting
2014/10 - 2014/10 MDS Awareness Day – Conference, Institute of Molecular Medicine, Lisbon, Portugal.
Conference
2013/02 - 2013/02 XVII CURSO Pós-graduação e actualização em Hematologia: Laboratório de Hematologia – Morfologia e Citometria. Faculdade de Farmácia da Universidade de Lisboa, Lisbon, Portugal.
Workshop
2010/12 - 2010/12 XVII National Congress on Biochemistry at Porto Palace Hotel, Oporto, Portugal
Congress
2010/05 - 2010/05 4th National meeting of Signal Transduction at University of Algarve, Faro, Portugal.
Meeting
2009/05 - 2009/05 3rd National meeting of Signal Transduction at University of Aveiro, Aveiro, Portugal.
Meeting
2008/05 - 2008/05 2nd National meeting of Signal Transduction at Institute for Molecular and Cell Biology, Oporto, Portugal.
Meeting
2007/06 - 2007/06 1st IMM PhD student Meeting at Institute of Molecular Medicine, Lisbon, Portugal.
Meeting
2007/03 - 2007/03 1st National meeting of Signal Transduction at Institute of Molecular Medicine, Lisbon, Portugal.
Meeting
2006/12 - 2006/12 XVth National Congress of Biochemistry at University of Aveiro, Aveiro, Portugal.
Congress
2006/03 - 2006/03 Smart Toxicology Subcellular targets of Anti-Cancer Therapy at University of Coimbra, Coimbra, Portugal.
Meeting
2005/11 - 2005/11 Workshop “Mechanisms of T cell recognition and activation”, IBMC, Oporto, Portugal.
Workshop
2004/02 - 2004/02 XXXI Jornadas Portuguesas de Genética at ITQB, Oeiras, Portugal.
Meeting

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/28 Impact of anti CTLA4 and anti PD1 on the cross talk between cancer and immune cells, underlying CAT VTE
(Thesis) Main arguer
 Catarina Dias (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/11/09 Search for novel modulators of NIS abundance and retention at the plasma membrane to enhance iodide uptake
(Thesis) Main arguer
 José Vareda (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/02/14 Unraveling the relevance of ARL1 GTPase in cutaneous melanoma aggressiveness
(Thesis) Main arguer
 Inês Saraiva (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/05/04 Circulatory Biomarkers of Melanoma Metastasis
(Thesis) Main arguer
 José Maximiano (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/01/12 Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia: a review and identification of a novel player - CASZ1
Thesis Member
 Francisco Miguel da Cruz Vaz Borges Alexandrino (Master)
Instituto de Medicina Molecular, Portugal
2021/03/05 Development of Cellular Models for NIS Functional Expression
(Thesis) Main arguer
 Bruno Alexandre Dias Martins (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/12/17 Study of novel compounds for the treatment of anaplastic thyroid carcinomas
(Thesis) Main arguer
 Ana Teresa de Sousa e Menezes Matias (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Association member

Society Organization name Role
2022/07 - Current Sociedade Portuguesa de Hematologia (SPH) Member
2014 - Current European Association for Cancer Research (EACR) Member
2014 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014/09 - 2014/09 Theoretical lesson for the practical course - "Introdução à cultura de células animais". Lesson entitled: "Resistência Terapêutica em Neoplasias Hematológicas: O papel da medula Óssea." - IPOL-FG, Lisbon, Portugal.

Journal scientific committee

Journal title (ISSN) Publisher
2023/06 - Current Frontiers in Hematology (Research Topic Editor) (2813-3935) Frontiers
2023 - Current European Journal of Haematology (1600-0609) Wiley Online Library
2023 - Current European Journal of Inflammation (1721-727X) Sage Journals
2021 - Current Biomolecules (2218-273X) MDPI
2020/06 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2020 - Current Biology (2079-7737) MPDI
2019 - Current Advances in Biological Regulation (2212-4926) Elsevier
2019 - Current Cellular Signalling (0898-6568) Elsevier
2018 - Current Cancer Biomarkers (1875-8592) IOS Press
2018 - Current Cancers (2072-6694) MDPI AG
2017 - Current Cells (2073-4409) MDPI
2017 - Current Cell Cycle (1551-4005) Landes Bioscience
2015 - Current Leukemia Research (0145-2126) Elsevier

Mentoring / Tutoring

Topic Student name
2018/09 - 2019/09 Francisco Alexandrino
2019/01 - 2019/05 Hannah Taylor

Other jury / evaluation

Activity description Institution / Organization
2020/07/03 - 2020/07/03 Main examiner of the "Projeto em Biologia Celular e Molecular" presented by the Bsc student Beatriz Pereira under the "Biologia Celular e Molecular" degree at the Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa (Webinar based presentation).
2019/02 - 2019/02 Main examiner of the “Seminário de Investigação III” presented by the PhD student Joana Filipa Pereira under the Biochemistry PhD programme at Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal. Universidade de Lisboa Faculdade de Ciências, Portugal
Distinctions

Award

2018 Best oral presentation at the 3rd ASPIC International Congress (10-11 May, Lisbon) with the work intituled”CASZ1 is overexpressed in T-cell acute lymphoblastic leukemia and promotes cell transformation and tumor growth via PI3K-mTOR.”
Associação Portuguesa de Investigação em Cancro, Portugal

Other distinction

2005 Merit Schorlarship
Universidade de Lisboa Faculdade de Ciências, Portugal