Juan Alberto Varela (0F1E-9491-BE6A)

Curriculum Vitae

Juan Alberto Varela

Juan Alberto Varela. Completed the Doctor of Philosophy in PhD in Physical Chemistry in 2011/12/06 by University College Dublin and Licence in Licenciatura en Fisica in 2006/02/01 by Universidad de la República Uruguay. Is Principal Investigator in University of St Andrews. Published 19 articles in journals. Has 1 section(s) of books. Participates and/or participated as Principal investigator in 1 project(s). In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Animals; Biological; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Models; N-Methyl-D-Aspartate; N-Methyl-D-Aspartate: metabolism; Neuronal Plasticity; Rats; Receptors; Synapses; Synapses: physiology; bio-nanotechnology; cellular uptake; nanoparticles; single particle tracking; Cell Line; Tumor; Cell Membrane Permeability; Coloring Agents; Coloring Agents: analysis; Coloring Agents: chemistry; Humans; Kinetics; Lysosomes; Lysosomes: metabolism; Lysosomes: ultrastructure; Nanoparticles; Nanoparticles: analysis; Nanoparticles: chemistry; Polymers; Polymers: chemistry; 1321n1 human astrocytoma cells; 7 and 9 activation; amine-modified nanoparticles; apoptosis; caspases 3; .

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Identification

Personal identification

Full name: Juan Alberto Varela

Citation names

Varela, Juan

Author identifiers

Ciência ID: 0F1E-9491-BE6A
ORCID iD: 0000-0003-1901-1378

Websites

https://synergy.st-andrews.ac.uk/neurophotonics/ (Professional)

Education

	Degree	Classification
2007/10/01 - 2011/12/06 Concluded	PhD in Physical Chemistry (Doctor of Philosophy) Major in Bio-nanotechnology University College Dublin, Ireland
1998/03/01 - 2006/02/01 Concluded	Licenciatura en Fisica (Licence) Major in Physics Universidad de la República Uruguay, Uruguay

Affiliation

Science

	Category Host institution	Employer
2018/12/01 - Current	Principal Investigator (Research)	University of St Andrews, United Kingdom

2015/07/01 - 2018/11/30	Postdoc (Research)	University of Cambridge Department of Chemistry, United Kingdom

2011/12/01 - 2015/06/30	Postdoc (Research)	Institut Interdisciplinaire de Neurosciences, France

Others

	Category Host institution	Employer
2021/09/01 - Current	Reader in Biophotonics	University of St Andrews School of Physics and Astronomy, United Kingdom

Projects

Grant

	Designation	Funders
2018/12/01 - 2023/11/30	Nanoscale dynamics in the extracellular space of the brain in vivo 804581 Principal investigator	European Research Council
2020/07/01 - 2023/06/30	Correlating local complexity of the extracellular space of the brain with clearance efficiency of amyloidogenic oligomers 527 (AS-PhD-19a-016) Principal investigator	Alzheimer's Society Ongoing
2019/10/01 - 2021/09/30	Dead-space microdomains in the extracellular space of the brain as traps for amyloid beta oligomers ARUK-PPG2019A-005 Principal investigator	Alzheimer's Research Trust Ongoing

Contract

	Designation	Funders
2013/07/01 - 2015/06/30	DEEP BRAIN TISSUE IMAGING OF GLUTAMATE NMDAR 326442 Research Fellow	European Research Council

Outputs

Publications

Book chapter

Varela, Juan. "Single Nanoparticle Tracking of Surface Ion Channels and Receptors in Brain Cells". edited by Luj{\'a, 49-58. Springer New York, 2016.
10.1007/978-1-4939-3064-7_5

Journal article

Rodrigues, M.; Bhattacharjee, P.; Brinkmalm, A.; Do, D. T.; Pearson, C. M.; De, S.; Ponjavic, A.; et al. "Structure-specific amyloid precipitation in biofluids". Nature Chemistry 14 9 (2022): 1045-1053. http://dx.doi.org/10.1038/s41557-022-00976-3.
10.1038/s41557-022-00976-3
Varela, Juan. "ThX – a next-generation probe for the early detection of amyloid aggregates". Chemical Science (2020): http://dx.doi.org/10.1039/c9sc04730a.
10.1039/c9sc04730a
Suman De; David C. Wirthensohn; Patrick Flagmeier; Craig Hughes; Francesco A. Aprile; Francesco S. Ruggeri; Daniel R. Whiten; et al. "Different soluble aggregates of Aß42 can give rise to cellular toxicity through different mechanisms". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-019-09477-3.
10.1038/s41467-019-09477-3
Juan A. Varela; Margarida Rodrigues; Suman De; Patrick Flagmeier; Sonia Gandhi; Christopher M. Dobson; David Klenerman; Steven F. Lee. "Optical Structural Analysis of Individual a-Synuclein Oligomers". Angewandte Chemie 130 18 (2018): 4980-4984. https://doi.org/10.1002/ange.201710779.
10.1002/ange.201710779
Qamar S; Wang G; Randle SJ; Ruggeri FS; Varela JA; Lin JQ; Phillips EC; et al. "FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions.". Cell (2018): http://europepmc.org/abstract/med/29677515.
10.1016/j.cell.2018.03.056
Varela JA; Rodrigues M; De S; Flagmeier P; Gandhi S; Dobson CM; Klenerman D; Lee S. "Optical structural analysis of individual a-synuclein oligomers.". Angewandte Chemie (International ed. in English) (2018): http://europepmc.org/abstract/med/29342318.
10.1002/anie.201710779
Noémie Danné; Antoine G. Godin; Zhenghong Gao; Juan A. Varela; Laurent Groc; Brahim Lounis; Laurent Cognet. "Comparative Analysis of Photoluminescence and Upconversion Emission from Individual Carbon Nanotubes for Bioimaging Applications". ACS Photonics (2017): https://doi.org/10.1021%2Facsphotonics.7b01311.
10.1021/acsphotonics.7b01311
Godin AG; Varela JA; Gao Z; Danné N; Dupuis JP; Lounis B; Groc L; Cognet L. "Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain.". (2016): http://europepmc.org/abstract/med/27870840.
10.1038/nnano.2016.248
Åberg C; Varela JA; Fitzpatrick LW; Dawson KA. "Spatial and Structural Metrics for Living Cells Inspired by Statistical Mechanics.". (2016): http://europepmc.org/abstract/med/27708351.
10.1038/srep34457
Varela, Juan. "Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue.". Neurophotonics (2016): http://europepmc.org/abstract/med/27429996.
10.1117/1.NPh.3.4.041808
Varela, Juan. "Toward the suppression of cellular toxicity from single-walled carbon nanotubes.". Biomaterials Science (2016): http://europepmc.org/abstract/med/26678092.
10.1039/c5bm00134j
Varela, Juan. "Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices.". Nature Communications (2016): http://europepmc.org/abstract/med/26971573.
10.1038/ncomms10947
Murphy-Royal, Ciaran; Dupuis, Julien P; Varela, Juan a; Panatier, Aude; Pinson, Beno\^{\i. "Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission". Nature Neuroscience 18 2 (2015): 219-226. http://www.nature.com/neuro/journal/v18/n2/full/nn.3901.html.
10.1038/nn.3901
Varela, Juan A.; \AA berg, Christoffer; Simpson, Jeremy C.; Dawson, Kenneth A.. "Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies". Small (2014): n/a-n/a. http://doi.wiley.com/10.1002/smll.201401849.
10.1002/smll.201401849
Genin, Emilie; Gao, Zhenghong; Varela, Juan A; Daniel, Jonathan; Bsaibess, Talia; Gosse, Isabelle; Groc, Laurent; Cognet, Laurent; Blanchard-Desce, Mireille. ""Hyper-bright" near-infrared emitting fluorescent organic nanoparticles for single particle tracking.". Advanced Materials 26 14 (2014): 2258-61, 2257. http://doi.wiley.com/10.1002/adma.201304602.
10.1002/adma.201304602
Dupuis, Julien P; Lad\'{e. "Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses.". The EMBO journal 33 8 (2014): 842-61. http://www.ncbi.nlm.nih.gov/pubmed/24591565.
10.1002/embj.201386356
Varela, Juan A; Bexiga, Mariana G; \AA berg, Christoffer; Simpson, Jeremy C; Dawson, Kenneth A. "Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells.". Journal of Nanobiotechnology 10 (2012): 39-39. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3492040\&tool=pmcentrez\&rendertype=abstract.
10.1186/1477-3155-10-39
Salvati, Anna; Aberg, Christoffer; dos Santos, Tiago; Varela, Juan; Pinto, Paulo; Lynch, Iseult; Dawson, Kenneth a. "Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics.". Nanomedicine : nanotechnology, biology, and medicine 7 6 (2011): 818-26. http://www.ncbi.nlm.nih.gov/pubmed/21453790.
10.1016/j.nano.2011.03.005
dos Santos, Tiago; Varela, Juan; Lynch, Iseult; Salvati, Anna; Dawson, Kenneth A. "Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines.". Small 7 23 (2011): 3341-9. http://www.ncbi.nlm.nih.gov/pubmed/22009913.
10.1002/smll.201101076
Varela, Juan. "Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line". Nanotoxicology 5 4 (2011): 557-567. http://www.ncbi.nlm.nih.gov/pubmed/21142842.
10.3109/17435390.2010.539713
dos Santos, Tiago; Varela, Juan; Lynch, Iseult; Salvati, Anna; Dawson, Kenneth A. "Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines.". PloS ONE 6 9 (2011): e24438-e24438. http://www.ncbi.nlm.nih.gov/pubmed/21949717 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3176276\&tool=pmcentrez\&rendertype=abstract.
10.1371/journal.pone.0024438
Cabeza, Cecilia; Varela, Juan; Bove, Italo; Freire, Daniel; Marti´, Arturo C.; Sarasu´a, L. G.; Usera, Gabriel; Montagne, Raul; Araujo, Moacyr. "Two-layer stratified flows over pronounced obstacles at low-to-intermediate Froude numbers". Physics of Fluids 21 4 (2009): 044102-044102. http://scitation.aip.org/content/aip/journal/pof2/21/4/10.1063/1.3110108.
10.1063/1.3110108
Varela, J; Araujo, M; Bove, I; Cabeza, C; Usera, G; Marti, a; Montagne, R; Sarasua, L. "Instabilities developed in stratified flows over pronounced obstacles". Physica A: Statistical Mechanics and its Applications 386 2 (2007): 681-685. http://linkinghub.elsevier.com/retrieve/pii/S0378437107009569.
10.1016/j.physa.2007.08.051