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Hélio M. T. Albuquerque was born in Amarante (Portugal) in 1985. He graduated in Chemistry from Faculty of Sciences of the University of Porto (FCUP) in 2008. Then, he followed his master studies in the same institution alongside with a STSM at the University of Vigo. After that, he moved to CICECO - University of Aveiro as a research fellow in the field of heterogeneous catalysis. In 2012, he moved to QOPNA (UA) to work in the synthesis of new chromone-based antioxidants. In 2017, he received his Ph.D. in Chemistry, with honors and distinction, from the University of Aveiro, under the supervision of Prof. Artur M. S. Silva. Currently, he is a doctoral researcher of the “Molecular Synthesis” group at REQUIMTE-LAQV – Aveiro Pole. Published 31 articles in peer-review SC-Indexed journals (h-index 13, 554 citations), one European patent application, 3 book chapters, delivered 3 invited talks, and is author or co-author of 5 proceedings and 18 oral communications in scientific meetings. His research focus includes the development of innovative synthetic methods for bioactive heterocycles and steroid-based compounds targeting neurodegenerative diseases, synthetic steroids as new antivirals, as well as in the discovery of new catalysts for modern C-H activation. Dr Albuquerque is the co-Principal Investigator (co-PI) of the FCT-funded project MuTaTher-AD: Multi-target theranostics for Alzheimer's disease (2022.06064.PTDC - 244k€) and supervisor of 4 PhD students, 1 MSc student and 1 research fellow in the fields of Medicinal, Organic and Computational Chemistry. He was recently appointed by SPQ as the Portuguese representative in the 14th Young Investigator Workshop (YIW2023) - EuChemS Division of Organic Chemistry and received an ACS complimentary membership in recognition of his outstanding ACS peer-reviewing activities. He is also member of the Editorial Board of Frontiers in Chemistry, section of Medicinal and Pharmaceutical Chemistry and member of the Crowd Reviewer’s Board of SynOpen.
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Identification

Personal identification

Full name
Hélio Miguel Teixeira Albuquerque
Date of birth
1985/09/11
Gender
Male

Citation names

  • Albuquerque, Hélio
  • Hélio M. T. Albuquerque

Author identifiers

Ciência ID
1016-A240-06C2
ORCID iD
0000-0001-5905-3316
Scopus Author Id
56728165300

Email addresses

  • helio.albuquerque@ua.pt (Professional)

Telephones

Mobile phone
  • 916551789 (Personal)
Telephone
  • 234370200 (Professional)
  • 234135521 (Personal)

Addresses

  • Universidade de Aveiro. Campus Universitário de Santiago, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2024/02/05 - 2024/02/09
Concluded
 Enabling technologies in Chemical Synthesis (Curso de Especialização Tecnológica)
Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
2017/07/25
Concluded
 Doctoral Program in Chemistry (Doutoramento)
Major in Quimica Orgânica
Universidade de Aveiro, Portugal
" Cycloaddition and conjugated addition reactions of C-2-substituted chromones with unsaturated systems" (THESIS/DISSERTATION)
 Distinção e Louvor (the maximum)
2009
Concluded
 Master of Science in Chemistry (MSc) (2nd cycle) (Mestrado)
Major in Quimica Orgânica e Alimentar
Universidade do Porto Faculdade de Ciências, Portugal
"Determination of the location and antioxidant activity of olive oil polyphenols in model food emulsions." (THESIS/DISSERTATION)
 16 out of 20
2008
Concluded
 Chemistry (1st cycle) (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 12 out of 20
Affiliation

Science

Category
Host institution 		Employer
2021/07/20 - Current Researcher (Research) Universidade de Aveiro Departamento de Química, Portugal
Universidade de Aveiro Departamento de Química, Portugal
2017/09/15 - 2021/04/30 Postdoc (Research) Universidade de Aveiro, Portugal
Universidade de Aveiro, Portugal

Others

Category
Host institution 		Employer
2013/07/01 - 2017/06/30 FCT PhD grant (Ref. SFRH/BD/86277/2012), "Cycloaddition and conjugated addition reactions of C-2-substituted chromones with unsaturated systems." Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Universidade de Aveiro, Portugal
2011/08/01 - 2013/06/30 Research grant within the project: "New synthetic routes towards polyphenolic compounds with antioxidant activity" Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
2010/02/01 - 2011/06/30 Research grant within the project: Catalytic oxidation reactions by transition metal complexes confined into mesoporous structured solids"; PTDC/QUI/64770/2006. Universidade de Aveiro CICECO, Portugal
Projects

Grant

Designation Funders
2023/02 - 2026/01 Teranósticos multi-alvo para a doença de Alzheimer
Provided by PTCRIS: 2022.06064.PTDC
 Fundação para a Ciência e a Tecnologia
2018/07 - 2022/07 Novos compostos heterocíclicos de nitrogénio e oxigénio C-glicosilados como potenciais agentes anticancerígenos com ação epigenética imunoestimuladora
Provided by PTCRIS: PTDC/QUI-QOR/29767/2017
 Fundação para a Ciência e a Tecnologia
2013/07 - 2017/06 NOVAS ROTAS DE SÍNTESE DE FLAVONAS E XANTONAS: REAÇÕES DE CICLOADIÇÃO E DE ACOPLAMENTO CRUZADO CATALISADAS POR PALÁDIO
Provided by PTCRIS: SFRH/BD/86277/2012
 Fundação para a Ciência e a Tecnologia
2011/07 - 2013/01 NOVOS COMPOSTOS POLIFENÓLICOS COM POTENCIAL ACTIVIDADE ANTIOXIDANTE E ANTI-INFLAMATÓRIA
Provided by PTCRIS: SFRH/BI/51556/2011
 Fundação para a Ciência e a Tecnologia
2009/02 - 2012/07 CATALYTIC OXIDATION REACTIONS BY TRANSITION METAL COMPLEXES CONFINED INTO MESOPOROUS STRUCTURED SOLIDS
grant.Provided by PTCRIS: 64770
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2005/09 - 2008/06 Synthesis of chromones and in vitro evaluation of their antioxidant and anti-inflammatory properties
grant.Provided by PTCRIS: 59284
Research Fellow
Stichting Weten

Contract

Designation Funders
2021/07/20 - Current EpigenGlicON - Novos compostos heterocíclicos de nitrogénio e oxigénio C-glicosilados como potenciais agentes anticancerigenos com ação epigenética imunoestimuladora
POCl-01-0145-FEDER-029767
Researcher
Universidade de Aveiro Departamento de Química, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/02/01 - 2026/01/31 Multi-target theranostics for Alzheimer's disease
2022.06064.PTDC
10.54499/2022.06064.PTDC
Co-Principal Investigator (Co-PI)
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/09/15 - 2020/12/31 pAge project: Life-long protein aggregation
Centro-01-0145-FEDER-000003
Post-doc Fellow
Universidade de Aveiro, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2019/01/01 - 2019/12/31 Química Orgânica, Produtos Naturais e Agroalimentares
UID/QUI/00062/2019
Universidade de Aveiro, Portugal

Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Hélio M. T. Albuquerque. "Reduction of Carboxylic Acids and their Derivatives to Alcohols, Ethers, and Amines". In Comprehensive Organic Synthesis, third edition, edited by Nuno Maulide. Elsevier, 2025.
    Accepted
  2. Hélio M. T. Albuquerque; Candeias, Nuno R.. Corresponding author: Candeias, Nuno R.. "Diazo-mediated homologation reactions". In Homologation Reactions: Reagents, Applications and Mechanisms, edited by Vittorio Pace. Wiley VCH, 2022.
    Accepted
  3. Albuquerque, Hélio M. T.; Clementina M. M. Santos; Artur M. S. Silva. Corresponding author: Artur M. S. Silva. "Cholesterol chemistry and laboratory synthesis". In Cholesterol: From Chemistry and Biophysics to the Clinic, edited by Alex Dopico; Anna Bukiya. United States: Elsevier Science, 2022.
    Accepted
Conference abstract
  1. Albuquerque, Hélio. "Recent Developments in the Synthesis of Novel Xanthone-1,2,3-triazole Dyads". 2016.
    doi:10.3390/ph9010015
  2. Proença, Carina; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda. "The antioxidant activity of novel polyhydroxylated 3-hydroxy-2-styrylchromones and 3-hydroxyflavones". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry, Porto, 2016.
    Published
Conference paper
  1. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "P16-27: Combination effect of doxorubicin and flavonol with a pyrogallol moiety in osteosarcoma cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX 2023), Ljubljana, 2023.
    Published • https://doi.org/10.1016/S0378-4274(23)00718-X
  2. Santos, Isabela; Albuquerque, Hélio M. T.; Silva, Artur M. S.; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. "In Vitro Cytotoxicity of 7,3',4'-Trihydroxyflavones in Lung Fibroblasts". 2022.
    10.3390/ecmc2022-13254
  3. Pereira, Florbela; Lourenço, Ana; Aires-de-Sousa, João; Ferreira, Luísa M.; Marques, M. Manuel B.; Sousa, Emília; Branco, Paula S.. "14th Edition of the Nacional Organic Chemistry Meeting and 7th Edition of the Nacional Therapeutic Chemistry Meeting". 2022.
    10.3390/chemproc2022011001
  4. Albuquerque, Hélio; Silva, Raquel; Vieira, Sandra; Pereira, Marisa; Soares, Ana; Santos, Clementina M.M.; Silva, Artur. "Modulating protein aggregation in cell models using modified steroids". 2019.
  5. Albuquerque, Hélio; Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda; Silva, Artur. "Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives". 2018.
  6. Albuquerque, Hélio; Santos, Clementina M.M.; Balanay, Mannix P.; Cavaleiro, José; Silva, Artur. "Conjugate additions of carbon nucleophiles to chromones substituted with extended p-systems at C-2". 2017.
  7. Albuquerque, Hélio; Santos, Clementina M.M.; Cavaleiro, José; Silva, Artur. "Microwave-assisted synthesis of chromeno[3,4-b]xanthones and (benzo[c]cromenyl)chromones". 2017.
  8. Albuquerque, Hélio; Santos, Clementina M.M.; Cavaleiro, João; Silva, Artur. "Chromones as versatile building blocks in cycloaddition reactions". 2017.
  9. Albuquerque, Hélio; Santos, Clementina M.M.; Lima, C.F.R.A.C.; Santos, L.M.N.B.F.; Cavaleiro, José; Silva, Artur. "Chromone derivatives as novel dienes in Diels-Alder reactions". 2016.
  10. Albuquerque, Hélio; Santos, Clementina M.M.; Esteves, Cátia; Silva, Artur; Cavaleiro, José. "Synthesis of novel 2-Butadienylchromone derivatives". 2012.
Conference poster
  1. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "Myricetin exhibits antiproliferative and anti-migratory activity on osteosarcoma cells". Paper presented in 58th International Conference on Medicinal Chemistry - RICT 2024 - Interfacing Chemical Biology and Drug Discovery, 2024.
  2. Biscaia, Maria; Sarabando, Jéssica; Marques, Mariana; Nunes, Alexandre; Francisco, Telmo; Silva, Artur; Albuquerque, Hélio; Ribeiro, Daniela. "Investigating compounds that hinder protein aggregation as antivirals against respiratory viruses". Paper presented in RNA biology in host-pathogen interactions conference, 2024.
  3. Santos, Isabela; Albuquerque, Hélio; Pinto, Marta T; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. "Anti-osteosarcoma activity of robinetin and myricetin: in vitro and CAM studies". Paper presented in Second CAM Conference, 2024.
  4. Melo, Lúcia; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Melo, Lúcia. "Building novel amyloid probes featuring D-A-D architectures". Paper presented in 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, 2024.
  5. Melo, Lúcia; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Melo, Lúcia. "Building new amyloid probes with D-A-D architectures". Paper presented in XXVII Encontro Luso Galego de Química, 2023.
  6. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Unlocking the Synthesis of N-Heterocyclic Analogues of 3- Formylchromones". Paper presented in XXVII Encontro Luso-Galego de Química, 2023.
  7. Melo, Lúcia; Oliveira, Maria; Malafaia, Daniela; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Melo, Lúcia. "The role of tertiary amines in chromeno[3,4- b]xanthones for Alzheimer’s disease". Paper presented in I International Meeting Molecules 4Life, 2023.
  8. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "Combination effect of doxorubicin and flavonol with a pyrogallol moiety in osteosarcoma cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX 2023), 2023.
    10.1016/S0378-4274(23)00718-X
  9. Melo, Lúcia; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Melo, Lúcia. "Synthesis of steroid-quinoline hybrids with donor-acceptor architectures". Paper presented in XXVIII Encontro Nacional da SPQ, 2023.
  10. Malafaia, Daniela; Bras, Natercia F.; Fernandes, Pedro Alexandrino; Ramos, Maria; Silva, Artur; Albuquerque, Hélio. Corresponding author: Malafaia, Daniela. "Chromeno[3,4-b]xanthones: a new pathway towards the multitarget strategy for Alzheimer's disease". Paper presented in 22nd European Symposium on Organic Chemistry, 2023.
  11. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, J.M.P.. "Evaluation of the inhibitory activity of fisetin derivatives on osteosarcoma cell viability and migration". Paper presented in 57th International Conference on Medicinal Chemistry - RICT 2023 - Drug Discovery and Selection, 2023.
  12. Sarabando, Jéssica; Marques, Mariana; Ferreira, Ana Rita; Albuquerque, Hélio; Silva, Artur; Ribeiro, Daniela. "Unveiling the antiviral properties of steroid-styryl compounds against influenza A virus infection". Paper presented in Ciência 2023, 2023.
  13. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Synthesis of 3,5-Disubstituted Nitrobenzenes and their Applications". Paper presented in XXVIII Encontro Nacional da SPQ, 2023.
  14. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Silva, Artur M. S.; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "3,5-Disubstituted Nitrobenzenes: Synthesis and Applications". Paper presented in 22nd European Symposium on Organic Chemistry, 2023.
  15. Malafaia, Daniela; Bras, Natercia F.; Fernandes, Pedro Alexandrino; Ramos, Maria João; Silva, Artur; Albuquerque, Hélio. Corresponding author: Malafaia, Daniela. "Chromeno[3,4-b]xanthones: a new platform for the development of multitarget theranostics for Alzheimer's disease". Paper presented in Workshop on novel diagnostic tools for Alzheimer's disease, 2023.
  16. Sarabando, Jéssica; Marques, Mariana; Ferreira, Ana Rita; Albuquerque, Hélio; Silva, Artur; Ribeiro, Daniela. "Exploring the antiviral potential of steroid compounds against influenza A virus infection". Paper presented in VI iBiMED Symposium, 2023.
  17. Marques, Mariana; Ramos, Bruno; Hélio M. T. Albuquerque; Sarabando, Jéssica; Nunes, Alexandre; Ferreira, Ana Rita; Silva, Artur; et al. "Influenza A virus-induced formation of insoluble protein aggregates during infection as a potential target for novel host-derived antiviral strategies". Paper presented in 8th European Congress of Virology, 2023.
  18. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Artur M. S. Silva; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Synthesis of Symmetrical and Non-Symmetrical Nitrobenzenes from 3- Formylchromones". 2023.
  19. Artur M. S. Silva; Albuquerque, Hélio. "Chromeno[3,4 b ]xanthones: A privileged new class of multi target direct ligands for Alzheimer's Disease". Paper presented in 2nd Symposium on Alzheimer's Disease: Un update on Pathology and Therapeutics, 2023.
  20. Mariana Marques; Bruno Ramos; Albuquerque, Hélio; Artur M. S. Silva; Maria João Amorim; Soares, Ana Raquel; Daniela Ribeiro. "Targeting virus-induced accumulation of insoluble protein aggregates as an antiviral strategy against influenza A virus infection". Paper presented in XLVIII SPI Annual Meeting 2023, 2023.
  21. Santos, Isabela; Albuquerque, Hélio; Silva, Artur; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "Evaluation of the cytotoxicity effects of flavonol derivatives in human lung fibroblasts". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022.
  22. Mariana Marques; Hélio Albuquerque; Maria João Amorim ; Daniela Ribeiro; Ana Raquel Soares. Corresponding author: Mariana Marques. ""Influenza A virus induces IRE1 activation and the accumulation of protein aggregates to ensure efficient viral propagation"". Paper presented in American Society for Virology 2022 Annual Meeting, 2022.
  23. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Styrylpyrazoles and chromone derivatives as glycogen phosphorylase inhibitors: a combined enzyme kinetic and molecular docking study". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  24. Mariana Marques; Albuquerque, Hélio; Daniela Ribeiro ; Ana Raquel Soares. Corresponding author: Mariana Marques. "Influenza A virus induces the accumulation of insoluble protein aggregates to support efficient virus particle formation". 2022.
  25. Daniela Marisa Pinho Malafaia; Albuquerque, Hélio; Artur M. S. Silva. Corresponding author: Daniela Marisa Pinho Malafaia. "Chromeno[3,4-b]xanthones, a new class of Aß Aggregation inhibitors". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022.
  26. Marques, Mariana; Albuquerque, Hélio; Soares, Ana Raquel; Ribeiro, Daniela. "Exploring the interplay between influenza A virus and the host cell proteostasis". Paper presented in ASV (American Society for Virology) 2021, 2021.
  27. Daniela Malafaia; Telmo Francisco; Artur M. S. Silva; Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "Development of new AChE inhibitors". Paper presented in 13º ENQO/6º ENQT, 2020.
  28. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Nitromethane conjugate addition to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones". Paper presented in XXV Encontro Nacional SPQ, 2017.
  29. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Microwave-assisted synthesis of chromeno[3,4-b]xanthones and (benzo[c]chromenyl)chromones". Paper presented in TRAMECH IX, 2017.
  30. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Clementina M. M. Santos. "Chromones as versatile building blocks in cycloaddition reaction". Paper presented in 26th ISHC Congress, 2017.
  31. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Functionalization of chromone derivatives through conjugate addition – synthesis of novel nitrogen heterocycles". Paper presented in Encontro Ciência 2017, 2017.
  32. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles". Paper presented in Research Day UA, 2017.
  33. Proença, Carina; Albuquerque, Hélio; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda. "Novel chromones and xanthones target reactive nitrogen species in vitro". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 9th Edition, 2016.
  34. Hélio M. T. Albuquerque; Clementina M. M. Santos; Carlos F. R. A. C. Lima; Luís M. N. B. F. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as dienes in Diels-Alder reactions: Experimental and computational studies". Paper presented in Terceiro Simpósio Ibero-Americano de Química Orgânica, 2016.
  35. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Microwaves: A powerful tool for the synthesis of new structure complex oxygen heterocyclic compounds". Paper presented in Research Day UA, 2016.
  36. Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Fernandes, Eduarda. "The antioxidant activity of novel chromones and xanthones: a structure-activity relationship". Paper presented in XXI Encontro Luso-Galego de Química, 2015.
  37. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Synthesis of xanthone-1,2,3-triazole dyads". Paper presented in 19th ESOC - European Symposium of Organic Chemistry, 2015.
  38. Carina Proença; Hélio M. T. Albuquerque; Clementina M. M. Santos; Artur M. S. Silva; José A. S. Cavaleiro; Eduarda Fernandes. "Síntese de novas cromonas e xantonas com atividade captadora de espécies reativas de oxigénio". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  39. Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "2-(4-Arylbuta-1,3-dien- or 1-en-3-yn-1-yl)chromones as synthons for the synthesis of other nitrogen and oxygen heterocyclic compounds". Paper presented in Research Day UA, 2013.
  40. Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "Synthesis of 2-{2-[5(4)-aryl-2H-[1,2,3]-triazol-4(5)-yl]vinyl}chromen-4-ones". Paper presented in 10º Encontro Nacional de Química Orgânica, 2013.
  41. Hélio M. T. Albuquerque. "Synthesis of (E)-2-(4-arylbut-1-en-3-ynyl)-4H-chromen-4-ones". Paper presented in XXIII Encontro Nacional da SPQ, 2013.
  42. Hélio M. T. Albuquerque. "Synthesis of novel hydroxylated 2-butadienylchromone derivatives". Paper presented in 3.º Encontro Nacional de Química Terapêutica, 2012.
  43. Hélio Albuquerque. "Sílicas mesoporosas e correspondentes réplicas de carbono como suportes de catalisadores de ciclopropanação". Paper presented in Simpósio Ibero-Americano de Adsorção, 2012.
  44. Hélio Albuquerque. "Strategies for copper bis(oxazoline) immobilisation onto porous silica-based materials". Paper presented in ISHHC XV, 2011.
  45. Hélio Albuquerque. "Bis(oxazoline) anchored onto a hexagonal mesoporous silica as asymmetric heterogeneous catalyst in the cyclopropanation of styrene". Paper presented in X Jornadas do CICECO, 2011.
  46. Hélio Albuquerque; A. Fontes; Susana Borges; A. Nunes; Ana P. Carvalho; João Pires; Ana R. Silva. "Ciclopropanação de estireno por bis(oxazolina) de cobre(II) encapsulada em zeólitos". Paper presented in XXXV Reunião Ibérica de Adsorção (RIA), 2010.
  47. Hélio Albuquerque; Fátima Paiva-Martins; P. Torres; Sonia Losada-Barreiro; V. Sánchez-Paz; C. Bravo-Díaz. "Quantitative determination of olive oil phenols distribution in O/W food emulsions and their correlation with the antioxidant capacity". Paper presented in 8th Euro Fed Lipid Congress, 2010.
  48. Hélio Albuquerque; Ana Rosa Silva. "Strategies for the immobilisation of privileged ligands onto solid supports: bis(oxazoline) case study". Paper presented in 3rd EuCheMS Chemistry Congress, 2010.
  49. Hélio Albuquerque; Ana Rosa Silva. "Bis(oxazoline) anchored onto a hexagonal mesoporous silica as asymmetric heterogeneous catalyst in the cyclopropanation of styrene". Paper presented in 3rd EuCheMS Chemistry Congress, 2010.
  50. Hélio Albuquerque; Fátima Paiva-Martins; Carlos Bravo-Díaz. "Quantitative determination of oleuropein and 3,4-DHPEA-EDA distribution in olive oil/tween 80:span80/water food emulsion". Paper presented in 7th Euro Fed Lipid Congress, 2009.
Journal article
  1. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. "Flavonoids and the chemotherapeutic drugs methotrexate, doxorubicin, and cisplatin for the treatment of osteosarcoma: a review of synergistic effects and underlying mechanisms.". Phytochemistry Reviews (2025):
    Under revision
  2. Francisco, Telmo N.; Albuquerque, Hélio M. T.; Silva, Artur M. S.. Corresponding author: Albuquerque, Hélio M. T.. "An In-Depth Exploration of Six Decades of the Kröhnke Pyridine Synthesis". Chemistry – A European Journal 30 47 (2024): http://dx.doi.org/10.1002/chem.202401672.
    10.1002/chem.202401672
  3. Telmo N. Francisco; Malafaia, Daniela; Melo, Lúcia; Silva, Artur M. S.; Hélio M. T. Albuquerque. "Recent Advances in Fluorescent Theranostics for Alzheimer’s Disease: A Comprehensive Survey on Design, Synthesis, and Properties". ACS Omega (2024): http://dx.doi.org/10.1021/acsomega.3c10417.
    Accepted • 10.1021/acsomega.3c10417
  4. Marques, Mariana; Ramos, Bruno; Albuquerque, Hélio; Pereira, Marisa; Ribeiro, Diana Roberta; Nunes, Alexandre; Sarabando, Jéssica; et al. "Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates". iScience 27 3 (2024): 109100. http://dx.doi.org/10.1016/j.isci.2024.109100.
    10.1016/j.isci.2024.109100
  5. Santos, Isabela; Albuquerque, Hélio; Pinto, Marta T; Mendes, Nuno; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. "Robinetin is a novel inhibitor of osteosarcoma proliferation and migration acting through the Slug/Twist signaling axis". Biochimica & Biophysica Acta-Molecular Basis of Disease (2024):
    Under revision
  6. Joana L. C. Sousa; Hélio M. T. Albuquerque; Artur M. S. Silva. "Drug Discovery Based on Oxygen and Nitrogen (Non-)Heterocyclic Compounds Developed @LAQV–REQUIMTE/Aveiro". Pharmaceuticals (2023): https://doi.org/10.3390/ph16121668.
    10.3390/ph16121668
  7. Carina Proença; Ana Teresa Rufino; Isabela Santos; Hélio M. T. Albuquerque; Artur M. S. Silva; Eduarda Fernandes; José Miguel P. Ferreira de Oliveira. "Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth". Antioxidants (2023): https://doi.org/10.3390/antiox12091744.
    10.3390/antiox12091744
  8. Liza Saher; Fátima L. Monteiro; Djenisa H. A. Rocha; Hélio M. T. Albuquerque; Artur M. S. Silva; Luisa A. Helguero. "Selective Induction of DNA Damage and Cell Cycle Arrest Mediated by Chromone-Triazole Dyads Derivatives: Effects on Breast and Prostate Cancer Cells". Chemistry & Biodiversity (2023): https://doi.org/10.1002/cbdv.202300251.
    10.1002/cbdv.202300251
  9. Daniela Malafaia; Joana L. C. Sousa; Artur M. S. Silva; Hélio M. T. Albuquerque. "2,2'-[(1E,1'E)-{[Hexa-2,4-diyne-1,6-diylbis(oxy)]bis(2,1-phenylene)}bis(ethene-2,1-diyl)]bis(4H-chromen-4-one)". Molbank 2023 2 (2023): M1621-M1621. http://dx.doi.org/10.3390/m1621.
    10.3390/m1621
  10. Joana L. C. Sousa; Hélio M. T. Albuquerque; Artur M. S. Silva. "6-[(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidine-4-carbaldehyde". Molbank (2023): https://doi.org/10.3390/M1603.
    10.3390/M1603
  11. Isabela Santos; Hélio M. T. Albuquerque; Artur M. S. Silva; Fernandes, E.; Jose Miguel Ferreira de Oliveira. "In Vitro Cytotoxicity of 7,3',4'-Trihydroxyflavones in Lung Fibroblasts". Medical Sciences Forum (2022): https://www.mdpi.com/2673-9992/14/1/59.
    10.3390/ECMC2022-13254
  12. Artur M. S. Silva; Hélio M. T. Albuquerque; Telmo N. Francisco; Joana L. C. Sousa; Samuel Guieu. "Mild Synthesis of Symmetric 3,5-Disubstituted Nitrobenzenes". Synlett (2022): https://doi.org/10.1055/a-1875-2646.
    10.1055/a-1875-2646
  13. Joana L. C. Sousa; Hélio M. T. Albuquerque; Armando J. D. Silvestre; Artur M. S. Silva. "Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles". Molecules (2022): https://doi.org/10.3390/molecules27154904.
    10.3390/molecules27154904
  14. Albuquerque, Hélio M. T.; Nunes da Silva, Raquel; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M. M.; Vieira, Sandra I.; Silva, Artur M. S.. "Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes". ACS Medicinal Chemistry Letters (2022): http://dx.doi.org/10.1021/acsmedchemlett.1c00604.
    10.1021/acsmedchemlett.1c00604
  15. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; Maria Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles". Nutrients (2022): https://doi.org/10.3390/nu14020306.
    10.3390/nu14020306
  16. Hélio M. T. Albuquerque; Diana C. G. A. Pinto; Artur M. S. Silva. "Microwave Irradiation: Alternative Heating Process for the Synthesis of Biologically Applicable Chromones, Quinolones, and Their Precursors". Molecules 26 20 (2021): 6293-6293. https://doi.org/10.3390/molecules26206293.
    10.3390/molecules26206293
  17. João P.S. Ferreira; Hélio M.T. Albuquerque; Susana M. Cardoso; Artur M.S. Silva; Vera L.M. Silva. "Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)". European Journal of Medicinal Chemistry 221 (2021): 113492-113492. https://doi.org/10.1016/j.ejmech.2021.113492.
    10.1016/j.ejmech.2021.113492
  18. Malafaia, Daniela; Albuquerque, Hélio M.T.; Silva, Artur M.S.. "Amyloid-ß and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review". European Journal of Medicinal Chemistry 214 (2021): 113209. http://dx.doi.org/10.1016/j.ejmech.2021.113209.
    Published • 10.1016/j.ejmech.2021.113209
  19. Hélio M. T. Albuquerque; Maria J. Ramos; Pedro Manuel Azevedo Alexandrino Fernandes; Artur M. S. Silva; Daniela Marisa Pinho Malafaia. "Chromeno[3,4-b]xanthones as first-in-class AChE and Aß aggregation dual-inhibitors". International Journal of Molecular Sciences (2021):
    Submitted
  20. Albuquerque, Hélio M. T.; Francisco, Telmo; Malafaia, Daniela; Cavaleiro, José A. S.; Silva, Artur M. S.. "A-ring functionalization of cholestane with highly substituted pyrans and 2-aminoisophthalonitriles". Arkivoc 2020 7 (2021): http://dx.doi.org/10.24820/ark.5550190.p011.411.
    10.24820/ark.5550190.p011.411
  21. Hélio M. T. Albuquerque. "Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells". Journal of Molecular Structure (2020): http://dx.doi.org/10.1016/j.molstruc.2020.128325.
    10.1016/j.molstruc.2020.128325
  22. Djemoui, Amar; Naouri, Abdelkader; Ouahrani, Mohammed Ridha; Djemoui, Djamila; Lahcene, Souli; Lahrech, Mokhtar Boualem; Albuquerque, Hélio M.T.; et al. "A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+". Journal of Molecular Structure 1204 (2020): 127487. http://dx.doi.org/10.1016/j.molstruc.2019.127487.
    10.1016/j.molstruc.2019.127487
  23. Hélio M. T. Albuquerque; Clementina Santos; Artur M. S. Silva. "Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/116.
    10.3390/molecules24010116
  24. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva; Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones". New Journal of Chemistry 42 6 (2018): 4251-4260. https://doi.org/10.1039/C7NJ05185A.
    10.1039/C7NJ05185A
  25. Albuquerque, H.M.T.; Santos, C.M.M.; Balanay, M.P.; Cavaleiro, J.A.S.; Silva, A.M.S.. "1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones". European Journal of Organic Chemistry 2017 35 (2017): 5293-5305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029852555&partnerID=MN8TOARS.
    10.1002/ejoc.201700944
  26. Albuquerque, H.M.T.; Santos, C.M.M.; Lima, C.F.R.A.C.; Santos, L.M.N.B.F.; Cavaleiro, J.A.S.; Silva, A.M.S.. "2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies". European Journal of Organic Chemistry 2017 1 (2017): 87-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005808121&partnerID=MN8TOARS.
    10.1002/ejoc.201601072
  27. Proença, C.; Albuquerque, H.M.T.; Ribeiro, D.; Freitas, M.; Santos, C.M.M.; Silva, A.M.S.; Fernandes, E.. "Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 115 (2016): 381-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961962762&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.03.043
  28. Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads". European Journal of Organic Chemistry 2015 21 (2015): 4732-4743. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027941784&partnerID=MN8TOARS.
    10.1002/ejoc.201500448
  29. Albuquerque, H.; Carneiro, L.; Carvalho, A.P.; Pires, J.; Silva, A.R.. "Enantioselective cyclopropanation and aziridination catalyzed by copper(II) bis(oxazoline) anchored onto mesoporous materials". Polyhedron 79 (2014): 315-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902511611&partnerID=MN8TOARS.
    10.1016/j.poly.2014.05.025
  30. Albuquerque, Hélio; Santos, Clementina M.M.; Cavaleiro, José; Silva, Artur; Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces". Current Organic Chemistry 18 21 (2014): 2750-2775. http://hdl.handle.net/10198/11671.
    10.2174/1385272819666141013224253
  31. Silva, A.R.; Albuquerque, H.; Borges, S.; Siegel, R.; Mafra, L.; Carvalho, A.P.; Pires, J.. "Strategies for copper bis(oxazoline) immobilization onto porous silica based materials". Microporous and Mesoporous Materials 158 (2012): 26-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860526288&partnerID=MN8TOARS.
    10.1016/j.micromeso.2012.02.044
  32. Lisete-Torres, P.; Losada-Barreiro, S.; Albuquerque, H.; Sánchez-Paz, V.; Paiva-Martins, F.; Bravo-Díaz, C.. "Distribution of hydroxytyrosol and hydroxytyrosol acetate in olive oil emulsions and their antioxidant efficiency". Journal of Agricultural and Food Chemistry 60 29 (2012): 7318-7325. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864366261&partnerID=MN8TOARS.
    10.1021/jf301998s
  33. Silva, A.R.; Albuquerque, H.; Fontes, A.; Borges, S.; Martins, A.; Carvalho, A.P.; Pires, J.. "Copper bis(oxazoline) encapsulated in zeolites and its application as heterogeneous catalysts for the cyclopropanation of styrene". Industrial and Engineering Chemistry Research 50 20 (2011): 11495-11501. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054033861&partnerID=MN8TOARS.
    10.1021/ie201178d
Magazine article
  1. Hélio M. T. Albuquerque. "EuChemS: Division of Organic Chemistry – 14th Young Investigator Workshop", Boletim da Sociedade Portuguesa de Química (SPQ), 2024, https://b-quimica.spq.pt/magazines/bspquimica/709.
    10.52590/M3.P709.A30002778
  2. Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "Cromeno[3,4-b]xantonas: Novos Inibidores da Acetilcolinesterase e Agregação Beta-amiloide", Boletim da Sociedade Portuguesa de Química (SPQ), 2023, https://b-quimica.spq.pt/magazines/BSPQuimica/705.
    10.52590/M3.P705.A30002637
  3. Hélio M. T. Albuquerque. "Targeting Protein Aggregation with Steroid-Quinoline Hybrids and Chromeno[3,4-b]xanthones", Research@UA, 2022, https://proa.ua.pt/index.php/researchua/article/view/31684.
Preprint
  1. Mariana Marques; Bruno Ramos; Albuquerque, Hélio; Marisa Pereira; Diana Roberta Ribeiro; Alexandre Nunes; Sarabando, Jéssica; et al. Corresponding author: Soares, Ana Raquel. "Influenza A virus activates the unfolded protein response and induces the accumulation of insoluble protein aggregates that are essential for efficient viral propagation". 2023. https://doi.org/10.1101/2023.09.11.557148.
    https://doi.org/10.1101/2023.09.11.557148
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/08/01 Utilização de compostos do tipo cromona e esteróide no desenvolvimento de medicamentos para a doença de Alzheimer, proteinopatias, cancro e infeções virais LusoCiência
Gouveia city Council (Gouveia, Portugal)
2024/07/22 Unveiling the potential of chromeno[3,4-b]xanthones as a disruptive scaffold for Alzheimer’s disease 29th Congress of the International Society of Heterocyclic Chemistry
International Society of Heterocyclic Chemistry (Aveiro, Portugal)
2024/07/21 Targeting Protein Aggregation With Hybrid Quinoline-Steroid Compounds 29th Congress of the International Society of Heterocyclic Chemistry
International Society of Heterocyclic Chemistry (Aveiro, Portugal)
2024/07/21 Enabling the synthesis of 3-aminopyridines via stepwise Kröhnke reaction 29th Congress of the International Society of Heterocyclic Chemistry
International Society of Heterocyclic Chemistry (Aveiro, Portugal)
2024/07/01 Demystifying Chemistry TEDx Aveiro
TEDx (Aveiro, Portugal)
2023/07/08 Unlocking the potential of chromones and steroids to create chemical diversity and bioactive compounds 14th Young Investigator Workshop (EuChemS - Division of Organic Chemistry)
KU Leuven (Leuven, Belgium)
2023/06/04 Design and synthesis of steroid-quinoline hybrid compounds targeting protein aggregation processes Novel diagnostic tools for Alzheimer´s disease, Department of Medical Sciences
Department of Medical Sciences, University of Aveiro (Aveiro, Portugal)
2022/04/04 Chromeno[3,4-b]xanthones: First-in-Class AChE and Aß Aggregation Dual-Inhibitors
Sociedade Portuguesa de Química (Lisbon, Portugal)
2019/07/05 Modulating protein aggregation in cell models using modified steroids XXVI Encontro Nacional da Sociedade Portuguesa de Química
Sociedade Portuguesa de Química (Porto, Portugal)
2018/09/14 Design, synthesis and preliminary antioxidant evaluation of new hydroxy-chromone and xanthone derivatives
(Lecce, Italy)
2017/05/04 Microwaves: An important tool to overcome the low reactivity of dienes in cycloaddition reactions
Universidade de Aveiro (Avero)
2017/02/23 Conjugate additions of carbon nucleophiles to chromones substituted with extended p-systems at C-2
Sociedade Espanhola de Quimica (Ferrol, Spain)
2016/11/29 Chromone derivatives as novel dienes in Diels-Alder reactions
Sociedade Portuguesa de Química (Bragança, Portugal)
2015/12/03 Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads
Sociedade Portuguesa de Química (Porto)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/01/15 - Current Virtual screening of amyloid and tau aggregation inhibitors
Co-supervisor of Maria Inês Quintelas
 Computational Chemistry (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2024/01/01 - Current Development of dual-targeting probes for NIR-II fluorescent imaging of amyloid and tau species
Supervisor
 Chemistry (PhD)
Universidade de Aveiro, Portugal
2023/01/01 - Current Reinventing the chemistry of 3-formyl(chromones and quinolones) towards the synthesis of nitrobenzenes, pyridines and aza(xanthones and acridones)
Co-supervisor
 Chemistry (PhD)
Universidade de Aveiro, Portugal
2022/02/01 - Current Flavonoid-based compounds as novel lead drugs against TGF-beta signaling in osteosarcoma
Co-supervisor of Maria Isabela Pinho Santos
 Sustainable Chemistry (PhD)
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
2022/01/01 - Current Multi-target theranostics for Alzheimer’s disease
Co-supervisor of Daniela Malafaia
 Programa Doutoral em Química (PhD)
Universidade de Aveiro, Portugal
2020/02 - Current Synthesis of chromeno-xanthones as new AChE inhibitors
Supervisor of Inês Soure
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2021/09/20 - 2022/09/30 Steroid-based compounds as novel broad-spectrum antivirals
Co-supervisor of Francisco Mendes
 Mestrado em Biomedicina Molecular (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal
2022/01/20 - 2022/06/30 Síntese de librarias de compostos heterocíclicos oxigenados e nitrogenados e estudos de ligação desses compostos em enzimas DNMT e HDAC de células cancerígenas
Co-supervisor of Telmo Neves Francisco
 Organic Chemistry (Specialization course)
Universidade de Aveiro Departamento de Química, Portugal
2020/09/25 - 2021/12/21 New Synthetic Methods for Oxygen and Nitrogen Heterocycles
Co-supervisor of Telmo Neves Francisco
 Química (Master)
Universidade de Aveiro, Portugal
2019/09 - 2021/01/25 Multi-target theranostics for neurodegenerative diseases
Co-supervisor of Daniela Malafaia
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2019 - 2021 Multi-target theranostics for Alzheimer’s disease
Co-supervisor of Daniela Marisa Pinho Malafaia
 Bioquímica (Master)
Universidade de Aveiro, Portugal
2020/02 - 2020/06 Synthesis and AChE inhibition of steroidal fluorescent compounds
Supervisor of Lucia Melo
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2020 - 2020 A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells
Co-supervisor
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2020 - 2020 Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells
Co-supervisor
Universidade de Aveiro, Portugal
2019/02 - 2019/06 Development of synthetic steroidal AChE inhibitors
Supervisor of Telmo Francisco
 Bioquímica (Scientific initiation)
Universidade de Aveiro, Portugal
2019/02 - 2019/06 New multitarget coumarin-based theranostics
Supervisor of Daniela Sona
 Ciências Naturais - Química (Degree)
Universidade de Aveiro, Portugal
2019/02 - 2019/02 Development of quinoline-steroid theranostic hybrids for neurodegenerative diseases
Supervisor of Carolina Pires
 Bioquímica (Degree)
Universidade de Aveiro, Portugal
2018/02 - 2018/06 Development of new pyrazole based DNA biomarkers
Supervisor
 Bioquímica (Scientific initiation)
Universidade de Aveiro, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/09 Exploring the antiviral potential of steroid compounds against influenza A virus infection
(Thesis) Main arguer
 Jéssica Sarabando de Oliveira (Master)
Universidade de Aveiro Instituto de Biomedicina, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/05/07 - Current Nature Communications (2041-1723) Spinger Nature
2023/01/01 - Current European Journal of Medicinal Chemistry Reports (2772-4174) Elsevier
2023/01/01 - Current Biomedicines (2227-9059) MDPI
2022/01/01 - Current ACS Chemical Neuroscience (1948-7193) American Chemical Society (ACS)
2021/08/21 - Current European Journal of Medicinal Chemistry (0223-5234) Elsevier
2021/03/03 - Current Pharmaceuticals (1424-8247) MDPI
2021/02/03 - Current International Journal of Molecular Sciences (1422-0067) MDPI
2020/03/03 - Current Molbank (1422-8599) MDPI
2019 - Current Molecules (1420-3049) MDPI AG
2019 - Current Applied Sciences (2076-3417) MDPI

Association member

Society Organization name Role
2023/02/01 - Current American Chemical Society Member
2010/04/26 - Current Portuguese Chemical Society Member

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/12/02 HA has been interviewed by Chemistry & Engineering News (C&EN) magazine, giving his opinion as Medicinal Chemist working on AD drug discovery, about the impact of an amyloid study showing the formation pathways of tau filaments (Nature, 2023, DOI: 10.1038/s41586-023-06788-w), in the design of new small-molecules targeting the seed of aggregation Chemical & Engeneering News (C&EN)

Journal scientific committee

Journal title (ISSN) Publisher
2023/02/03 - Current Frontiers in Chemistry (2296-2646) Frontiers
2022/05/01 - Current SynOpen (2509-9396) Thieme Chemistry
Distinctions

Award

2023 Portuguese Chemical Society representative in the 14th Young Investigator Workshop (YIW2023) - EuChemS Division of Organic Chemistry, 7–8 July 2023, Leuven, Belgium
Sociedade Portuguesa de Química, Portugal
2023 American Chemical Society (ACS) complimentary membership in recognition of outstanding peer-reviewing activities (Membership Number: 32250497)
American Chemical Society, United States
2023 Best oral communication, I International Meeting Molecules 4Life, Vila Real, Portugal, 2023, OC12-TA
Sociedade Portuguesa de Química, Portugal
2022 Portuguese Chemical Society representative to 2nd ChemPubSoc Europe Early Career Researchers Meeting
ChemPubSoc Europe, Germany
2018 IUPAC attendance grant for an oral communication in the 28th ECHC congress – EUROPEAN COLLOQUIUM ON HETEROCYCLIC CHEMISTRY
International Union of Pure and Applied Chemistry, United States
2017 Participation grant in TRAMECH IX – TRANSMEDITERRANEAN COLLOQUIUM ON HETEROCYCLIC CHEMISTRY
International Union of Pure and Applied Chemistry, United States
2003 Honor board 2002/2003 of Externato de Vila Meâ, Amarante Portugal.

Other distinction

2017 Doutoramento com Distinção e Louvor
Universidade de Aveiro, Portugal