Hélio Miguel Teixeira Albuquerque (1016-A240-06C2)

Curriculum Vitae

Hélio M. T. Albuquerque was born in Amarante (Portugal) in 1985. He graduated in Chemistry from Faculty of Sciences of the University of Porto (FCUP) in 2008. Then, he followed his master studies in the same institution alongside with a STSM at the University of Vigo. After that, he moved to CICECO - University of Aveiro as a research fellow in the field of heterogeneous catalysis. In 2012, he moved to QOPNA (UA) to work in the synthesis of new chromone-based antioxidants. In 2017, he received his Ph.D. in Chemistry, with honors and distinction, from the University of Aveiro, under the supervision of Prof. Artur M. S. Silva. Currently, he is a doctoral researcher of the “Molecular Synthesis” group at REQUIMTE-LAQV – Aveiro Pole. Published 29 articles in peer-review SC-Indexed journals (h-index 13, 465 citations), one European patent application, 2 book chapters, 5 proceedings and is co-author of 15 oral communications, both in national and international scientific meetings. His research focus includes the development of innovative synthetic methods for bioactive heterocycles and steroid-based compounds targeting neurodegenerative diseases, synthetic steroids as new antivirals, as well as in the discovery of new catalysts for modern C-H activation. Dr Albuquerque is the co-Principal Investigator (co-PI) of the FCT-funded project MuTaTher-AD: Multi-target theranostics for Alzheimer's disease (2022.06064.PTDC - 244k€) and supervisor of 4 PhD students, 1 MSc student and 1 research fellow in the fields of Medicinal, Organic and Computational Chemistry. He was recently appointed by SPQ as the Portuguese representative in the 14th Young Investigator Workshop (YIW2023) - EuChemS Division of Organic Chemistry and received an ACS complimentary membership in recognition of his outstanding ACS peer-reviewing activities. He is also member of the Editorial Board of Frontiers in Chemistry, section of Medicinal and Pharmaceutical Chemistry and member of the Crowd Reviewer’s Board of SynOpen.

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Identification

Personal identification

Full name: Hélio Miguel Teixeira Albuquerque
Date of birth: 1985/09/11
Gender: Male

Citation names

Albuquerque, Hélio
Hélio M. T. Albuquerque

Author identifiers

Ciência ID: 1016-A240-06C2
ORCID iD: 0000-0001-5905-3316
Scopus Author Id: 56728165300

Email addresses

helio.albuquerque@ua.pt (Professional)

Telephones

Mobile phone

916551789 (Personal)

Telephone

234370200 (Professional)
234135521 (Personal)

Addresses

Universidade de Aveiro. Campus Universitário de Santiago, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences - Organic Chemistry

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Intermediate (B1)	Advanced (C1)	Intermediate (B1)	Intermediate (B1)
French	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2017/07/25 Concluded	Doctoral Program in Chemistry (Doutoramento) Major in Quimica Orgânica Universidade de Aveiro, Portugal " Cycloaddition and conjugated addition reactions of C-2-substituted chromones with unsaturated systems" (THESIS/DISSERTATION)	Distinção e Louvor (the maximum)
2009 Concluded	Master of Science in Chemistry (MSc) (2nd cycle) (Mestrado) Major in Quimica Orgânica e Alimentar Universidade do Porto Faculdade de Ciências, Portugal "Determination of the location and antioxidant activity of olive oil polyphenols in model food emulsions." (THESIS/DISSERTATION)	16 out of 20
2008 Concluded	Chemistry (1st cycle) (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "n/a" (THESIS/DISSERTATION)	12 out of 20

Affiliation

Science

	Category Host institution	Employer
2021/07/20 - Current	Researcher (Research)	Universidade de Aveiro Departamento de Química, Portugal
	Universidade de Aveiro Departamento de Química, Portugal
2017/09/15 - 2021/04/30	Postdoc (Research)	Universidade de Aveiro, Portugal
	Universidade de Aveiro, Portugal

Others

	Category Host institution	Employer
2013/07/01 - 2017/06/30	FCT PhD grant (Ref. SFRH/BD/86277/2012), "Cycloaddition and conjugated addition reactions of C-2-substituted chromones with unsaturated systems."	Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal
	Universidade de Aveiro, Portugal
2011/08/01 - 2013/06/30	Research grant within the project: "New synthetic routes towards polyphenolic compounds with antioxidant activity"	Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

2010/02/01 - 2011/06/30	Research grant within the project: Catalytic oxidation reactions by transition metal complexes confined into mesoporous structured solids"; PTDC/QUI/64770/2006.	Universidade de Aveiro CICECO, Portugal

Projects

Grant

	Designation	Funders
2018/07 - 2022/07	Novos compostos heterocíclicos de nitrogénio e oxigénio C-glicosilados como potenciais agentes anticancerígenos com ação epigenética imunoestimuladora Provided by PTCRIS: PTDC/QUI-QOR/29767/2017	Fundação para a Ciência e a Tecnologia
2013/07 - 2017/06	NOVAS ROTAS DE SÍNTESE DE FLAVONAS E XANTONAS: REAÇÕES DE CICLOADIÇÃO E DE ACOPLAMENTO CRUZADO CATALISADAS POR PALÁDIO Provided by PTCRIS: SFRH/BD/86277/2012	Fundação para a Ciência e a Tecnologia
2011/07 - 2013/01	NOVOS COMPOSTOS POLIFENÓLICOS COM POTENCIAL ACTIVIDADE ANTIOXIDANTE E ANTI-INFLAMATÓRIA Provided by PTCRIS: SFRH/BI/51556/2011	Fundação para a Ciência e a Tecnologia
2009/02 - 2012/07	CATALYTIC OXIDATION REACTIONS BY TRANSITION METAL COMPLEXES CONFINED INTO MESOPOROUS STRUCTURED SOLIDS grant.Provided by PTCRIS: 64770 Research Fellow	Fundação para a Ciência e a Tecnologia Concluded
2005/09 - 2008/06	Synthesis of chromones and in vitro evaluation of their antioxidant and anti-inflammatory properties grant.Provided by PTCRIS: 59284 Research Fellow	Stichting Weten

Contract

	Designation	Funders
2021/07/20 - Current	EpigenGlicON - Novos compostos heterocíclicos de nitrogénio e oxigénio C-glicosilados como potenciais agentes anticancerigenos com ação epigenética imunoestimuladora POCl-01-0145-FEDER-029767 Researcher Universidade de Aveiro Departamento de Química, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023/02/01 - 2026/01/31	Multi-target theranostics for Alzheimer's disease 2022.06064.PTDC 10.54499/2022.06064.PTDC Co-Principal Investigator (Co-PI) Universidade de Aveiro, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/09/15 - 2020/12/31	pAge project: Life-long protein aggregation Centro-01-0145-FEDER-000003 Post-doc Fellow Universidade de Aveiro, Portugal	Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior Ongoing
2019/01/01 - 2019/12/31	Química Orgânica, Produtos Naturais e Agroalimentares UID/QUI/00062/2019 Universidade de Aveiro, Portugal Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Book chapter	Hélio M. T. Albuquerque; Candeias, Nuno R.. Corresponding author: Candeias, Nuno R.. "Diazo-mediated homologation reactions". In Homologation Reactions: Reagents, Applications and Mechanisms, edited by Vittorio Pace. Wiley VCH, 2022. Accepted Albuquerque, Hélio M. T.; Clementina M. M. Santos; Artur M. S. Silva. Corresponding author: Artur M. S. Silva. "Cholesterol chemistry and laboratory synthesis". In Cholesterol: From Chemistry and Biophysics to the Clinic, edited by Alex Dopico; Anna Bukiya. United States: Elsevier Science, 2022. Accepted
Conference abstract	Albuquerque, Hélio. "Recent Developments in the Synthesis of Novel Xanthone-1,2,3-triazole Dyads". 2016. doi:10.3390/ph9010015 Proença, Carina; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda. "The antioxidant activity of novel polyhydroxylated 3-hydroxy-2-styrylchromones and 3-hydroxyflavones". Paper presented in 11th National Meeting of Organic Chemistry and 4th Meeting of Therapeutic Chemistry, Porto, 2016. Published
Conference paper	Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "P16-27: Combination effect of doxorubicin and flavonol with a pyrogallol moiety in osteosarcoma cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX 2023), Ljubljana, 2023. Published • https://doi.org/10.1016/S0378-4274(23)00718-X Albuquerque, Hélio; Silva, Raquel; Vieira, Sandra; Pereira, Marisa; Soares, Ana; Santos, Clementina M.M.; Silva, Artur. "Modulating protein aggregation in cell models using modified steroids". 2019.
Conference poster	Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "Combination effect of doxorubicin and flavonol with a pyrogallol moiety in osteosarcoma cells". Paper presented in 57th Congress of the European Societies of Toxicology (EUROTOX 2023), 2023. 10.1016/S0378-4274(23)00718-X Malafaia, Daniela; Bras, Natercia F.; Fernandes, Pedro Alexandrino; Ramos, Maria; Silva, Artur; Albuquerque, Hélio. Corresponding author: Malafaia, Daniela. "Chromeno[3,4-b]xanthones: a new pathway towards the multitarget strategy for Alzheimer's disease". Paper presented in 22nd European Symposium on Organic Chemistry, 2023. Santos, Isabela; Albuquerque, Hélio; Fernandes, Eduarda; Ferreira de Oliveira, J.M.P.. "Evaluation of the inhibitory activity of fisetin derivatives on osteosarcoma cell viability and migration". Paper presented in 57th International Conference on Medicinal Chemistry - RICT 2023 - Drug Discovery and Selection, 2023. Sarabando, Jéssica; Marques, Mariana; Ferreira, Ana Rita; Albuquerque, Hélio; Silva, Artur; Ribeiro, Daniela. "Unveiling the antiviral properties of steroid-styryl compounds against influenza A virus infection". Paper presented in Ciência 2023, 2023. Malafaia, Daniela; Bras, Natercia F.; Fernandes, Pedro Alexandrino; Ramos, Maria João; Silva, Artur; Albuquerque, Hélio. Corresponding author: Malafaia, Daniela. "Chromeno[3,4-b]xanthones: a new platform for the development of multitarget theranostics for Alzheimer's disease". Paper presented in Workshop on novel diagnostic tools for Alzheimer's disease, 2023. Sarabando, Jéssica; Marques, Mariana; Ferreira, Ana Rita; Albuquerque, Hélio; Silva, Artur; Ribeiro, Daniela. "Exploring the antiviral potential of steroid compounds against influenza A virus infection". Paper presented in VI iBiMED Symposium, 2023. Marques, Mariana; Ramos, Bruno; Hélio M. T. Albuquerque; Sarabando, Jéssica; Nunes, Alexandre; Ferreira, Ana Rita; Silva, Artur; et al. "Influenza A virus-induced formation of insoluble protein aggregates during infection as a potential target for novel host-derived antiviral strategies". Paper presented in 8th European Congress of Virology, 2023. Telmo N. Francisco; Sousa, Joana L. C.; Guieu, Samuel; Artur M. S. Silva; Hélio M. T. Albuquerque. Corresponding author: Telmo N. Francisco. "Synthesis of Symmetrical and Non-Symmetrical Nitrobenzenes from 3- Formylchromones". 2023. Artur M. S. Silva; Albuquerque, Hélio. "Chromeno[3,4 b ]xanthones: A privileged new class of multi target direct ligands for Alzheimer's Disease". Paper presented in 2nd Symposium on Alzheimer's Disease: Un update on Pathology and Therapeutics, 2023. Mariana Marques; Bruno Ramos; Albuquerque, Hélio; Artur M. S. Silva; Maria João Amorim; Soares, Ana Raquel; Daniela Ribeiro. "Targeting virus-induced accumulation of insoluble protein aggregates as an antiviral strategy against influenza A virus infection". Paper presented in XLVIII SPI Annual Meeting 2023, 2023. Santos, Isabela; Albuquerque, Hélio; Silva, Artur; Fernandes, Eduarda; Ferreira de Oliveira, José Miguel P.. Corresponding author: Ferreira de Oliveira, José Miguel P.. "Evaluation of the cytotoxicity effects of flavonol derivatives in human lung fibroblasts". Paper presented in XXVI Encontro Galego-Portugués de Química, 2022. Mariana Marques; Hélio Albuquerque; Maria João Amorim ; Daniela Ribeiro; Ana Raquel Soares. Corresponding author: Mariana Marques. ""Influenza A virus induces IRE1 activation and the accumulation of protein aggregates to ensure efficient viral propagation"". Paper presented in American Society for Virology 2022 Annual Meeting, 2022. Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; M. Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "Styrylpyrazoles and chromone derivatives as glycogen phosphorylase inhibitors: a combined enzyme kinetic and molecular docking study". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022. Mariana Marques; Albuquerque, Hélio; Daniela Ribeiro ; Ana Raquel Soares. Corresponding author: Mariana Marques. "Influenza A virus induces the accumulation of insoluble protein aggregates to support efficient virus particle formation". 2022. Daniela Marisa Pinho Malafaia; Albuquerque, Hélio; Artur M. S. Silva. Corresponding author: Daniela Marisa Pinho Malafaia. "Chromeno[3,4-b]xanthones, a new class of Aß Aggregation inhibitors". Paper presented in 14th National Organic Chemistry Meeting & 7th National Medicinal Chemistry Meeting, 2022. Marques, Mariana; Albuquerque, Hélio; Soares, Ana Raquel; Ribeiro, Daniela. "Exploring the interplay between influenza A virus and the host cell proteostasis". Paper presented in ASV (American Society for Virology) 2021, 2021. Daniela Malafaia; Telmo Francisco; Artur M. S. Silva; Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "Development of new AChE inhibitors". Paper presented in 13º ENQO/6º ENQT, 2020. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Nitromethane conjugate addition to 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones". Paper presented in XXV Encontro Nacional SPQ, 2017. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Microwave-assisted synthesis of chromeno[3,4-b]xanthones and (benzo[c]chromenyl)chromones". Paper presented in TRAMECH IX, 2017. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Clementina M. M. Santos. "Chromones as versatile building blocks in cycloaddition reaction". Paper presented in 26th ISHC Congress, 2017. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Functionalization of chromone derivatives through conjugate addition – synthesis of novel nitrogen heterocycles". Paper presented in Encontro Ciência 2017, 2017. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Conjugate additions of carbon nucleophiles to chromone derivatives towards nitrogen heterocycles". Paper presented in Research Day UA, 2017. Proença, Carina; Albuquerque, Hélio; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda. "Novel chromones and xanthones target reactive nitrogen species in vitro". Paper presented in Encontro de Investigação Jovem da Universidade do Porto - 9th Edition, 2016. Hélio M. T. Albuquerque; Clementina M. M. Santos; Carlos F. R. A. C. Lima; Luís M. N. B. F. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as dienes in Diels-Alder reactions: Experimental and computational studies". Paper presented in Terceiro Simpósio Ibero-Americano de Química Orgânica, 2016. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Microwaves: A powerful tool for the synthesis of new structure complex oxygen heterocyclic compounds". Paper presented in Research Day UA, 2016. Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Albuquerque, Hélio; Santos, Clementina M.M.; Silva, Artur; Fernandes, Eduarda. "The antioxidant activity of novel chromones and xanthones: a structure-activity relationship". Paper presented in XXI Encontro Luso-Galego de Química, 2015. Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva. Corresponding author: Hélio M. T. Albuquerque. "Synthesis of xanthone-1,2,3-triazole dyads". Paper presented in 19th ESOC - European Symposium of Organic Chemistry, 2015. Carina Proença; Hélio M. T. Albuquerque; Clementina M. M. Santos; Artur M. S. Silva; José A. S. Cavaleiro; Eduarda Fernandes. "Síntese de novas cromonas e xantonas com atividade captadora de espécies reativas de oxigénio". Paper presented in XX Encontro Luso-Galego de Química, 2014. Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "2-(4-Arylbuta-1,3-dien- or 1-en-3-yn-1-yl)chromones as synthons for the synthesis of other nitrogen and oxygen heterocyclic compounds". Paper presented in Research Day UA, 2013. Hélio M. T. Albuquerque. Corresponding author: Hélio M. T. Albuquerque. "Synthesis of 2-{2-[5(4)-aryl-2H-[1,2,3]-triazol-4(5)-yl]vinyl}chromen-4-ones". Paper presented in 10º Encontro Nacional de Química Orgânica, 2013. Hélio M. T. Albuquerque. "Synthesis of (E)-2-(4-arylbut-1-en-3-ynyl)-4H-chromen-4-ones". Paper presented in XXIII Encontro Nacional da SPQ, 2013. Hélio M. T. Albuquerque. "Synthesis of novel hydroxylated 2-butadienylchromone derivatives". Paper presented in 3.º Encontro Nacional de Química Terapêutica, 2012. Hélio Albuquerque. "Sílicas mesoporosas e correspondentes réplicas de carbono como suportes de catalisadores de ciclopropanação". Paper presented in Simpósio Ibero-Americano de Adsorção, 2012. Hélio Albuquerque. "Strategies for copper bis(oxazoline) immobilisation onto porous silica-based materials". Paper presented in ISHHC XV, 2011. Hélio Albuquerque. "Bis(oxazoline) anchored onto a hexagonal mesoporous silica as asymmetric heterogeneous catalyst in the cyclopropanation of styrene". Paper presented in X Jornadas do CICECO, 2011. Hélio Albuquerque; A. Fontes; Susana Borges; A. Nunes; Ana P. Carvalho; João Pires; Ana R. Silva. "Ciclopropanação de estireno por bis(oxazolina) de cobre(II) encapsulada em zeólitos". Paper presented in XXXV Reunião Ibérica de Adsorção (RIA), 2010. Hélio Albuquerque; Fátima Paiva-Martins; P. Torres; Sonia Losada-Barreiro; V. Sánchez-Paz; C. Bravo-Díaz. "Quantitative determination of olive oil phenols distribution in O/W food emulsions and their correlation with the antioxidant capacity". Paper presented in 8th Euro Fed Lipid Congress, 2010. Hélio Albuquerque; Ana Rosa Silva. "Strategies for the immobilisation of privileged ligands onto solid supports: bis(oxazoline) case study". Paper presented in 3rd EuCheMS Chemistry Congress, 2010. Hélio Albuquerque; Ana Rosa Silva. "Bis(oxazoline) anchored onto a hexagonal mesoporous silica as asymmetric heterogeneous catalyst in the cyclopropanation of styrene". Paper presented in 3rd EuCheMS Chemistry Congress, 2010. Hélio Albuquerque; Fátima Paiva-Martins; Carlos Bravo-Díaz. "Quantitative determination of oleuropein and 3,4-DHPEA-EDA distribution in olive oil/tween 80:span80/water food emulsion". Paper presented in 7th Euro Fed Lipid Congress, 2009.
Journal article	Joana L. C. Sousa; Hélio M. T. Albuquerque; Artur M. S. Silva. "Drug Discovery Based on Oxygen and Nitrogen (Non-)Heterocyclic Compounds Developed @LAQV–REQUIMTE/Aveiro". Pharmaceuticals (2023): https://doi.org/10.3390/ph16121668. 10.3390/ph16121668 Carina Proença; Ana Teresa Rufino; Isabela Santos; Hélio M. T. Albuquerque; Artur M. S. Silva; Eduarda Fernandes; José Miguel P. Ferreira de Oliveira. "Gossypetin Is a Novel Modulator of Inflammatory Cytokine Production and a Suppressor of Osteosarcoma Cell Growth". Antioxidants (2023): https://doi.org/10.3390/antiox12091744. 10.3390/antiox12091744 Liza Saher; Fátima L. Monteiro; Djenisa H. A. Rocha; Hélio M. T. Albuquerque; Artur M. S. Silva; Luisa A. Helguero. "Selective Induction of DNA Damage and Cell Cycle Arrest Mediated by Chromone-Triazole Dyads Derivatives: Effects on Breast and Prostate Cancer Cells". Chemistry & Biodiversity (2023): https://doi.org/10.1002/cbdv.202300251. 10.1002/cbdv.202300251 Daniela Malafaia; Joana L. C. Sousa; Artur M. S. Silva; Hélio M. T. Albuquerque. "2,2'-[(1E,1'E)-{[Hexa-2,4-diyne-1,6-diylbis(oxy)]bis(2,1-phenylene)}bis(ethene-2,1-diyl)]bis(4H-chromen-4-one)". Molbank 2023 2 (2023): M1621-M1621. http://dx.doi.org/10.3390/m1621. 10.3390/m1621 Joana L. C. Sousa; Hélio M. T. Albuquerque; Artur M. S. Silva. "6-[(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl]-5-fluoropyrimidine-4-carbaldehyde". Molbank (2023): https://doi.org/10.3390/M1603. 10.3390/M1603 Isabela Santos; Hélio M. T. Albuquerque; Artur M. S. Silva; Fernandes, E.; Jose Miguel Ferreira de Oliveira. "In Vitro Cytotoxicity of 7,3',4'-Trihydroxyflavones in Lung Fibroblasts". Medical Sciences Forum (2022): https://www.mdpi.com/2673-9992/14/1/59. 10.3390/ECMC2022-13254 Artur M. S. Silva; Hélio M. T. Albuquerque; Telmo N. Francisco; Joana L. C. Sousa; Samuel Guieu. "Mild Synthesis of Symmetric 3,5-Disubstituted Nitrobenzenes". Synlett (2022): https://doi.org/10.1055/a-1875-2646. 10.1055/a-1875-2646 Joana L. C. Sousa; Hélio M. T. Albuquerque; Armando J. D. Silvestre; Artur M. S. Silva. "Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles". Molecules (2022): https://doi.org/10.3390/molecules27154904. 10.3390/molecules27154904 Albuquerque, Hélio M. T.; Nunes da Silva, Raquel; Pereira, Marisa; Maia, André; Guieu, Samuel; Soares, Ana Raquel; Santos, Clementina M. M.; Vieira, Sandra I.; Silva, Artur M. S.. "Steroid–Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes". ACS Medicinal Chemistry Letters (2022): http://dx.doi.org/10.1021/acsmedchemlett.1c00604. 10.1021/acsmedchemlett.1c00604 Sónia Rocha; Natália Aniceto; Rita C. Guedes; Hélio M. T. Albuquerque; Vera L. M. Silva; Artur M. S. Silva; Maria Luísa Corvo; Eduarda Fernandes; Marisa Freitas. "An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles". Nutrients (2022): https://doi.org/10.3390/nu14020306. 10.3390/nu14020306 Marques, Mariana; Ramos, Bruno; Ferreira, Ana Rita; Alexandre Nunes; Marisa Pereira; Amorim, Maria Joao; Albuquerque, Hélio; et al. "Influenza A virus disturbs the host-cell protein homeostasis by inducing the accumulation of insoluble proteins (in preparation)". (2022): Hélio M. T. Albuquerque; Diana C. G. A. Pinto; Artur M. S. Silva. "Microwave Irradiation: Alternative Heating Process for the Synthesis of Biologically Applicable Chromones, Quinolones, and Their Precursors". Molecules 26 20 (2021): 6293-6293. https://doi.org/10.3390/molecules26206293. 10.3390/molecules26206293 João P.S. Ferreira; Hélio M.T. Albuquerque; Susana M. Cardoso; Artur M.S. Silva; Vera L.M. Silva. "Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)". European Journal of Medicinal Chemistry 221 (2021): 113492-113492. https://doi.org/10.1016/j.ejmech.2021.113492. 10.1016/j.ejmech.2021.113492 Malafaia, Daniela; Albuquerque, Hélio M.T.; Silva, Artur M.S.. "Amyloid-ß and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review". European Journal of Medicinal Chemistry 214 (2021): 113209. http://dx.doi.org/10.1016/j.ejmech.2021.113209. Published • 10.1016/j.ejmech.2021.113209 Hélio M. T. Albuquerque; Maria J. Ramos; Pedro Manuel Azevedo Alexandrino Fernandes; Artur M. S. Silva; Daniela Marisa Pinho Malafaia. "Chromeno[3,4-b]xanthones as first-in-class AChE and Aß aggregation dual-inhibitors". International Journal of Molecular Sciences (2021): Submitted Albuquerque, Hélio M. T.; Francisco, Telmo; Malafaia, Daniela; Cavaleiro, José A. S.; Silva, Artur M. S.. "A-ring functionalization of cholestane with highly substituted pyrans and 2-aminoisophthalonitriles". Arkivoc 2020 7 (2021): http://dx.doi.org/10.24820/ark.5550190.p011.411. 10.24820/ark.5550190.p011.411 Hélio M. T. Albuquerque. "Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells". Journal of Molecular Structure (2020): http://dx.doi.org/10.1016/j.molstruc.2020.128325. 10.1016/j.molstruc.2020.128325 Djemoui, Amar; Naouri, Abdelkader; Ouahrani, Mohammed Ridha; Djemoui, Djamila; Lahcene, Souli; Lahrech, Mokhtar Boualem; Albuquerque, Hélio M.T.; et al. "A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells+". Journal of Molecular Structure 1204 (2020): 127487. http://dx.doi.org/10.1016/j.molstruc.2019.127487. 10.1016/j.molstruc.2019.127487 Hélio M. T. Albuquerque; Clementina Santos; Artur M. S. Silva. "Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/116. 10.3390/molecules24010116 Hélio M. T. Albuquerque; Clementina M. M. Santos; José A. S. Cavaleiro; Artur M. S. Silva; Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "First intramolecular Diels–Alder reactions using chromone derivatives: synthesis of chromeno[3,4-b]xanthones and 2-(benzo[c]chromenyl)chromones". New Journal of Chemistry 42 6 (2018): 4251-4260. https://doi.org/10.1039/C7NJ05185A. 10.1039/C7NJ05185A Albuquerque, H.M.T.; Santos, C.M.M.; Balanay, M.P.; Cavaleiro, J.A.S.; Silva, A.M.S.. "1,6-Conjugate Additions of Carbon Nucleophiles to 2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones". European Journal of Organic Chemistry 2017 35 (2017): 5293-5305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029852555&partnerID=MN8TOARS. 10.1002/ejoc.201700944 Albuquerque, H.M.T.; Santos, C.M.M.; Lima, C.F.R.A.C.; Santos, L.M.N.B.F.; Cavaleiro, J.A.S.; Silva, A.M.S.. "2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies". European Journal of Organic Chemistry 2017 1 (2017): 87-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85005808121&partnerID=MN8TOARS. 10.1002/ejoc.201601072 Proença, C.; Albuquerque, H.M.T.; Ribeiro, D.; Freitas, M.; Santos, C.M.M.; Silva, A.M.S.; Fernandes, E.. "Novel chromone and xanthone derivatives: Synthesis and ROS/RNS scavenging activities". European Journal of Medicinal Chemistry 115 (2016): 381-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961962762&partnerID=MN8TOARS. 10.1016/j.ejmech.2016.03.043 Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "(E)-2-(4-Arylbut-1-en-3-yn-1-yl)chromones as Synthons for the Synthesis of Xanthone-1,2,3-triazole Dyads". European Journal of Organic Chemistry 2015 21 (2015): 4732-4743. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027941784&partnerID=MN8TOARS. 10.1002/ejoc.201500448 Albuquerque, H.; Carneiro, L.; Carvalho, A.P.; Pires, J.; Silva, A.R.. "Enantioselective cyclopropanation and aziridination catalyzed by copper(II) bis(oxazoline) anchored onto mesoporous materials". Polyhedron 79 (2014): 315-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902511611&partnerID=MN8TOARS. 10.1016/j.poly.2014.05.025 Albuquerque, H.M.T.; Santos, C.M.M.; Cavaleiro, J.A.S.; Silva, A.M.S.. "Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocycles". Current Organic Chemistry 18 21 (2014): 2750-2775. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925949986&partnerID=MN8TOARS. Silva, A.R.; Albuquerque, H.; Borges, S.; Siegel, R.; Mafra, L.; Carvalho, A.P.; Pires, J.. "Strategies for copper bis(oxazoline) immobilization onto porous silica based materials". Microporous and Mesoporous Materials 158 (2012): 26-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860526288&partnerID=MN8TOARS. 10.1016/j.micromeso.2012.02.044 Lisete-Torres, P.; Losada-Barreiro, S.; Albuquerque, H.; Sánchez-Paz, V.; Paiva-Martins, F.; Bravo-Díaz, C.. "Distribution of hydroxytyrosol and hydroxytyrosol acetate in olive oil emulsions and their antioxidant efficiency". Journal of Agricultural and Food Chemistry 60 29 (2012): 7318-7325. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864366261&partnerID=MN8TOARS. 10.1021/jf301998s Silva, A.R.; Albuquerque, H.; Fontes, A.; Borges, S.; Martins, A.; Carvalho, A.P.; Pires, J.. "Copper bis(oxazoline) encapsulated in zeolites and its application as heterogeneous catalysts for the cyclopropanation of styrene". Industrial and Engineering Chemistry Research 50 20 (2011): 11495-11501. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054033861&partnerID=MN8TOARS. 10.1021/ie201178d
Preprint	Mariana Marques; Bruno Ramos; Albuquerque, Hélio; Marisa Pereira; Diana Roberta Ribeiro; Alexandre Nunes; Sarabando, Jéssica; et al. Corresponding author: Soares, Ana Raquel. "Influenza A virus activates the unfolded protein response and induces the accumulation of insoluble protein aggregates that are essential for efficient viral propagation". 2023. https://doi.org/10.1101/2023.09.11.557148. https://doi.org/10.1101/2023.09.11.557148

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/04/04	Chromeno[3,4-b]xanthones: First-in-Class AChE and Aß Aggregation Dual-Inhibitors	Sociedade Portuguesa de Química (Lisbon, Portugal)
2019/07/05	Modulating protein aggregation in cell models using modified steroids	XXVI Encontro Nacional da Sociedade Portuguesa de Química Sociedade Portuguesa de Química (Porto, Portugal)
2018/09/14	Design, synthesis and preliminary antioxidant evaluation of new hydroxy-chromone and xanthone derivatives	(Lecce, Italy)
2017/05/04	Microwaves: An important tool to overcome the low reactivity of dienes in cycloaddition reactions	Universidade de Aveiro (Avero)
2017/02/23	Conjugate additions of carbon nucleophiles to chromones substituted with extended p-systems at C-2	Sociedade Espanhola de Quimica (Ferrol, Spain)
2016/11/29	Chromone derivatives as novel dienes in Diels-Alder reactions	Sociedade Portuguesa de Química (Bragança, Portugal)
2015/12/03	Recent developments in the synthesis of novel xanthone-1,2,3-triazole dyads	Sociedade Portuguesa de Química (Porto)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2024/01/15 - Current	Virtual screening of amyloid and tau aggregation inhibitors Co-supervisor of Maria Inês Quintelas	Computational Chemistry (Other) Universidade do Porto Faculdade de Ciências, Portugal
2024/01/01 - Current	Development of dual-targeting probes for NIR-II fluorescent imaging of amyloid and tau species Co-supervisor	Chemistry (PhD) Universidade de Aveiro, Portugal
2023/01/01 - Current	Reinventing the chemistry of 3-formyl(chromones and quinolones) towards the synthesis of nitrobenzenes, pyridines and aza(xanthones and acridones) Co-supervisor	Chemistry (PhD) Universidade de Aveiro, Portugal
2022/02/01 - Current	Flavonoid-based compounds as novel lead drugs against TGF-beta signaling in osteosarcoma Co-supervisor of Maria Isabela Pinho Santos	Sustainable Chemistry (PhD) Universidade de Aveiro, Portugal Universidade do Porto Faculdade de Farmácia, Portugal
2022/01/01 - Current	Multi-target theranostics for Alzheimer’s disease Co-supervisor of Daniela Malafaia	Programa Doutoral em Química (PhD) Universidade de Aveiro, Portugal
2020/02 - Current	Synthesis of chromeno-xanthones as new AChE inhibitors Supervisor of Inês Soure	Bioquímica (Degree) Universidade de Aveiro, Portugal
2021/09/20 - 2022/09/30	Steroid-based compounds as novel broad-spectrum antivirals Co-supervisor of Francisco Mendes	Mestrado em Biomedicina Molecular (Master) Universidade de Aveiro Instituto de Biomedicina, Portugal
2022/01/20 - 2022/06/30	Síntese de librarias de compostos heterocíclicos oxigenados e nitrogenados e estudos de ligação desses compostos em enzimas DNMT e HDAC de células cancerígenas Co-supervisor of Telmo Neves Francisco	Organic Chemistry (Specialization course) Universidade de Aveiro Departamento de Química, Portugal
2020/09/25 - 2021/12/21	New Synthetic Methods for Oxygen and Nitrogen Heterocycles Co-supervisor of Telmo Neves Francisco	Química (Master) Universidade de Aveiro, Portugal
2019/09 - 2021/01/25	Multi-target theranostics for neurodegenerative diseases Co-supervisor of Daniela Malafaia	Bioquímica (Master) Universidade de Aveiro, Portugal
2019 - 2021	Multi-target theranostics for Alzheimer’s disease Co-supervisor of Daniela Marisa Pinho Malafaia	Bioquímica (Master) Universidade de Aveiro, Portugal
2020/02 - 2020/06	Synthesis and AChE inhibition of steroidal fluorescent compounds Supervisor of Lucia Melo	Bioquímica (Degree) Universidade de Aveiro, Portugal
2020 - 2020	A step-by-step synthesis of triazole-benzimidazole-chalcone hybrids: Anticancer activity in human cells Co-supervisor	Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2020 - 2020	Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells Co-supervisor	Universidade de Aveiro, Portugal
2019/02 - 2019/06	Development of synthetic steroidal AChE inhibitors Supervisor of Telmo Francisco	Bioquímica (Scientific initiation) Universidade de Aveiro, Portugal
2019/02 - 2019/06	New multitarget coumarin-based theranostics Supervisor of Daniela Sona	Ciências Naturais - Química (Degree) Universidade de Aveiro, Portugal
2019/02 - 2019/02	Development of quinoline-steroid theranostic hybrids for neurodegenerative diseases Supervisor of Carolina Pires	Bioquímica (Degree) Universidade de Aveiro, Portugal
2018/02 - 2018/06	Development of new pyrazole based DNA biomarkers Supervisor	Bioquímica (Scientific initiation) Universidade de Aveiro, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2021/12/09	Exploring the antiviral potential of steroid compounds against influenza A virus infection (Thesis) Main arguer	Jéssica Sarabando de Oliveira (Master) Universidade de Aveiro Instituto de Biomedicina, Portugal

Ad Hoc journal article review

	Journal title (ISSN)	Publisher
2023/01/01 - Current	European Journal of Medicinal Chemistry Reports (2772-4174)	Elsevier
2023/01/01 - Current	Biomedicines (2227-9059)	MDPI
2022/01/01 - Current	ACS Chemical Neuroscience (1948-7193)	American Chemical Society (ACS)
2021/08/21 - Current	European Journal of Medicinal Chemistry (0223-5234)	Elsevier
2021/03/03 - Current	Pharmaceuticals (1424-8247)	MDPI
2021/02/03 - Current	International Journal of Molecular Sciences (1422-0067)	MDPI
2020/03/03 - Current	Molbank (1422-8599)	MDPI
2019 - Current	Molecules (1420-3049)	MDPI AG
2019 - Current	Applied Sciences (2076-3417)	MDPI

Interview (newspaper / magazine)

	Activity description	Newspaper / Forum
2023/12/01	Provide an expert opinion on the development of amyloid aggregation inhibitors.	Chemical & Engeneering News (C&EN)

Journal scientific committee

	Journal title (ISSN)	Publisher
2023/09/01 - Current	Frontiers in Chemistry (2296-2646)	Frontiers
2022/05/01 - Current	SynOpen (2509-9396)	Thieme Chemistry

Distinctions

Award

2023	Portuguese Chemistry Society representative in the 14th Young Investigator Workshop (YIW2023) - EuChemS Division of Organic Chemistry, 7–8 July 2023, Leuven, Belgium Sociedade Portuguesa de Química, Portugal
2023	American Chemical Society (ACS) complimentary membership in recognition of outstanding peer-reviewing activities (Membership Number: 32250497) American Chemical Society, United States
2023	Best oral communication, I International Meeting Molecules 4Life, Vila Real, Portugal, 2023, OC12-TA Sociedade Portuguesa de Química, Portugal
2022	Best MSc Thesis in Medicinal Chemistry of 2021 Sociedade Portuguesa de Química, Portugal
2018	IUPAC attendance grant for an oral communication in the 28th ECHC congress – EUROPEAN COLLOQUIUM ON HETEROCYCLIC CHEMISTRY International Union of Pure and Applied Chemistry, United States
2017	Participation grant in TRAMECH IX – TRANSMEDITERRANEAN COLLOQUIUM ON HETEROCYCLIC CHEMISTRY International Union of Pure and Applied Chemistry, United States
2003	Honor board 2002/2003 of Externato de Vila Meâ, Amarante Portugal.

Other distinction

2020	Invitation to 2nd ChemPubSoc Europe Early Career Researchers Meeting ChemPubSoc Europe, Germany
2017	Doutoramento com Distinção e Louvor Universidade de Aveiro, Portugal