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Jorge Salvador has a degree in Pharmaceutical Sciences, (University of Coimbra) a master's degree in Organic & Technological Chemistry, (New University of Lisbon), and a Ph.D. in Pharmacy-Pharmaceutical Chemistry (University of Coimbra in collaboration with the University of York, U.K.). He spent one year as a Postdoc student at the University of Sussex, UK. Post-grad. (1-year certif.) Cancer Biology & Therapeutics-HICR from Harvard-Medical School, University of Harvard, USA. He has a position as a Full Professor at the Faculty of Pharmacy of the University of Coimbra ¿ Portugal and is a Non-Executive Member of the Board of CHEM4PHARMA, a start-up Pharmaceutical Company located in Portugal. Group leader of the research group ¿ Medicinal Chemistry & Drug Discovery¿ at the Center for Neuroscience and Cell Biology (CNC) at the University of Coimbra, Portugal. His research group activity has been focused on studies of new semisynthetic steroid, diterpenoid, and triterpenoid derivatives with improved antitumor activity and investigation of their mechanisms of anticancer action. In addition, the discovery of novel PARP-1 inhibitors able to reverse anticancer chemoresistance and sensitize cancer cells to chemotherapy is another line of research. Furthermore, enzyme inhibitors able to tackle hormone-dependent cancers, such as 5alpha-reductase and CYP17 inhibitors on prostatic cancer, are pursued in the group as well as new anticancer drugs acting on ubiquitin-proteasome system (UPS). The green pharmaceutical processes, aiming to reach target molecules in a more efficient, eco-friendly, and cheaper manner are continuously pursued in the group. Quite recently, he has been involved in studies on pharmacophore and structure-based drug discovery for the rational design of lead compound inhibitors of BACE1 and Glutaminyl Cyclase for Alzheimer's disease treatment. Recently, his research group started a new area of research related to the use of PROTACs in the treatment of cancer. He has edited 3 books and published about 125 ISI journal papers, including Nat. Prod. Reports, Journal for ImmunoTherapy of Cancer, Briefings in Bioinformatics, J. Med. Chem., Eur. J. Med. Chem., Expert Opinion on Therapeutic Patents, Green Chemistry, Drug Discovery Today, among others, 16 book chapters and, 10 patents (2 US Patents granted). In addition, he is the author/co-author of more than 250 presentations at national and international conferences and workshops. Supervisor of 5 post-doc students, 22 Ph.D. students (15 concluded; 7 ongoings), and > 45 MSc students. Over the last few years, he has conducted several research projects in the field of pharmaceutical/medicinal chemistry which has contributed to his significant expertise in drug discovery. -Member of evaluation committees from Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Research Council and other international funding agencies, INSERM, (National Science Centre, Poland, Swiss National Science Foundation, Research Foundation-Flanders, Belgian, France, Argentine, Brazil, among others) -Member of evaluation committees from A3ES. -Reviewer of the European Research Council, ERC Advanced Grants. - Arbitral Tribunal expert, (Industrial protection). 2014-Member of the Board of Directors of the MedChemTrain Ph.D. program, Univ. Coimbra. 2015-Coordinator of the Master in Medicinal Chemistry 2010-2017; 2021- Coordinator of the Master in Industrial Pharmaceutical Chemistry 2016-Director of the Mass Spectrometry Unity, University of Coimbra 2015-Editorial Advisory Board of Current Green Chemistry 2019-Guest Editor of Frontiers in Oncology 2020-Editorial Board, Molecules, Medicinal Chemistry Section 2021-Editorial Board, International Journal of Molecular Sciences 2021-Member of the General Council of the University of Coimbra 2021-Head of Lab. of Pharmaceutical/Medicinal Chemistry at FFUC -2024-26 Future President, Division of Medicinal Chemistry & Chemical Biology of the SPQ.
Identification

Personal identification

Full name
JORGE ANTÓNIO RIBEIRO SALVADOR

Citation names

  • SALVADOR, J.A.R.
  • Jorge A. R. Salvador, Salvador, J.

Author identifiers

Ciência ID
1112-4DB1-C082
ORCID iD
0000-0003-0779-6083
Google Scholar ID
https://scholar.google.pt/citations?user=w6fpgvYAAAAJ&hl=en
Researcher Id
N-7174-2017
Scopus Author Id
ID: 7101616974

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/10/26
Concluded
Cancer Biology & Therapeutics-HICR (1 year cert.) (Pós-Graduação)
Harvard Medical School, United States
2006/01/11
Concluded
Habilitation, Pharmaceutical Chemistry (Título de Agregado)
Universidade de Coimbra, Portugal
2001/10/01
Concluded
University of Sussex, Department of Chemistry (Pós-doutoramento)
University of Sussex, United Kingdom
1998/01/20
Concluded
Doutoramento em Ciências Farmacêuticas (Doutoramento)
Universidade de Coimbra, Portugal
"Reacções de Oxidação com Reagentes em Suportes Sólidos Usando Esteróides como Substratos" (THESIS/DISSERTATION)
Muito Bom com distinção e louvor por unanimidade
1992/11/23
Concluded
Mestrado em Química Orgânica e Tecnológica (Mestrado)
Universidade Nova de Lisboa Departamento de Química, Portugal
"Aplicação de Ultra-Sons a Reacções com Zinco em Esteróides" (THESIS/DISSERTATION)
Muito Bom
1987/07/31
Concluded
Licenciatura em Ciências Farmacêuticas- Farmácia Industrial (Licenciatura)
Universidade de Coimbra, Portugal
16 valores
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2013/04/07 - Current Full Professor (University Teacher) Universidade de Coimbra, Portugal
2002/11/26 - 2013/04/06 Associate Professor (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1998/01/21 - 2002/11/25 Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1992/11/24 - 1998/01/20 Assistant (University Teacher) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Grant

Designation Funders
1999/09/01 - 2000/10/01 The Partial Synthesis of Some Biologically Active Steroids
1999-00
Post-doc Fellow
University of Sussex Department of Chemistry and Biochemistry, United Kingdom
Concluded

Contract

Designation Funders
2020/01/01 - 2023/12/31 Strategic Plan-Centro de Química de Coimbra Coimbra Chemistry Center
UIDB/00313/2020
UIDP/00313/2020
Researcher
Ongoing
2020/01/01 - 2023/12/31 Srategic Plan-Institute for Biomedical Imaging and Translational Research
UIDB/04950/2020
UIDP/04950/2020
Researcher
Ongoing
2020/01/01 - 2023/12/31 Strategic Plan -Center for Innovative Biomedicine and Biotechnology
UIDP/04539/2020
UIDB/04539/2020
Researcher
Ongoing
2017 - 2021 Projects for the Development and Implementation of Research Infrastructures inserted in the ESFRI. National Mass Spectrometry Network. UC node .
RNEM POCI-01-0145-FEDER-022125
Principal investigator
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2020 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery .
Ref: PTDC/QEQ-MED/7042/2014
Ref: PTDC/QEQ-MED/7042/2014
Researcher
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2019/12/31 Drugs2CAD-Treatment of cancer and Alzheimer's diseases: discovering new drugs.
Ref. CENTRO-01-0247-FEDER-003269
Principal investigator
Chem4pharma, Portugal
Concluded
2012 - 2016 UC-NMR: A voyage from chemical space to biological Funtion.
RECI/QEQ-QFI/0168/2012
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2014 Strategic Project - LA 1.
PEst-C/SAU/LA0001/2013
Researcher
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012 - 2014 Avaliação da Atividade Anticancerígena de Novos Triterpenóides Pentacíclicos:Estudo da Inibição da poli (ADP-ribose) polimerase (PARP-1).
MaisCentro-QREN
Principal investigator
Concluded
2011 - 2012 Avaliação da actividade anticancerígena de novos derivados do ácido oleanólico e do ácido ursólico: estudo da inibição do proteassoma.
MaisCentro-QREN
Principal investigator
Universidade de Coimbra Faculdade de Farmácia, Portugal
Concluded
2011 - 2012 Avaliação da actividade anticancerígena de novos triterpenóides pentacíclicos de núcleo ursano: estudo da inibição do proteassoma.
MaisCentro-QREN
Principal investigator
Universidade de Coimbra Faculdade de Farmácia, Portugal
Concluded
2007 - 2008 Neuroactive Steroids: Synthesis and Studies on the Modulation of GABAA Receptor.
GRICES-ASCR (Czech Rep) 2007–2008
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Concluded
2002 - 2006 Cromatografia Líquida-Espectrometria de Massa na Análise de Compostos Bioactivos.
CONC-REEQ/850/2001
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2006 Laboratório de Ressonância Magnética Nuclear de Alta Resolução em Moléculas Pequenas.
Ref: CONC-REEQ/ 481/2001
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2005 Projecto para reforço das competências técnicas do IPN.
PRIME/MEDIDA B125
Principal investigator
IPN - Instituto Pedro Nunes., Portugal
Concluded
1998 - 2002 Catálise Estereoselectiva de Reacções de Hidroformilação e Hidrogenação por Transferência de Hidrogénio de Olefinas pró-quirais. Preparação de Produtos com Interesse Farmacológico.
PRAXIS XXI/P/QUI/10008/98
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1998 - 2000 A Síntese Química e a Sociedade. Fármacos e Saúde
CIÊNCIA VIVA-PIII-475
Researcher
Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1993 - 1997 Organic Synthetic Applications, programa de Química de Cooperação Europeia em Investigação Científica e Técnica, COST D6.
D6/0008/93 COST D6
PhD Student Fellow
Universidade de Coimbra Faculdade de Farmácia, Portugal
Concluded
Outputs

Publications

Book
  1. Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics. Frontiers Media SA. 2021.
    Published • 10.3389/978-2-88966-759-8 • Editor
  2. Jorge A. R. Salvador; M. M. Silva. Chemistry and Biological Activity of Steroids. United Kingdom: IntechOpen. 2020.
    10.5772/intechopen.77331 • Editor
  3. Salvador, J.A.R.. Pentacyclic triterpenes as promising agents in cancer. New York, United States: Nova Science Publishers. 2011.
    Published • Editor
Book chapter
  1. Cruz Silva, Maria Manuel; António Ribeiro Salvador, Jorge. "Introductory Chapter: Chemistry and Biological Activity of Steroids - Scope and Overview". In Chemistry and Biological Activity of Steroids. IntechOpen, 2020.
    10.5772/intechopen.88781
  2. Jorge A. R. Salvador; M.M.Silva. "Preface". In Chemistry and Biological Activity of Steroids, Preface/page i-Preface/page ii. United Kingdom: IntechOpen, 2020.
    Published • 10.1016/b978-1-85573-345-9.50003-0
  3. Salete J Baptista; Maria MC Silva; Jorge A.R.Salvador. "PARP-1 Mediated DNA Repair and its Inhibition by Small Molecules". 1-44. 2017.
    Published
  4. Jorge A. R. Salvador; M. Manuel C. Silva; Samuel M. Silvestre. "Recent Highligts in Green Oxidative Chemical Processes Applied to Steroid Chemistry". IN TECH, 2016.
  5. Salvador, J.A.R.; Leal, A.S.; Alho, D.P.S.; Gonçalves, B.M.F.; Valdeira, A.S.; Mendes, V.I.S.; Jing, Y.. "Highlights of pentacyclic triterpenoids in the cancer settings". 2014.
    10.1016/B978-0-444-63294-4.00002-4
  6. A. R. Salvador, Jorge; M. A. Pinto, Rui; M. Silvestre, Samuel. "Application of Bismuth(III) Reagents and Catalysts to the Synthesis of Heterocyclic Compounds of Pharmaceutical Interest". In Advances in Organic Synthesis, 64-181. BENTHAM SCIENCE PUBLISHERS, 2013.
    10.2174/9781608054756113040005
  7. R. Salvador, Jorge A.; M., Vania; M., Samuel. "Steroidal CYP17 Inhibitors for Prostate Cancer Treatment: From Concept to Clinic". In Advances in Prostate Cancer. InTech, 2013.
    10.5772/52290
  8. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Highlights of bismuth (III) salts applications in the synthesis of compounds of pharmaceutical interest". 2012.
  9. Salvador, J.A.R.. "Preface". 2011.
  10. Salvador, J.A.R.; Leal, A.S.M.; Santos, R.C.. "Semisynthetic pentacyclic triterpenoids in the cancer setting: Oleanolic acid and its derivatives". 2011.
  11. Salvador, J.A.R.; Moreira, V.M.. "Semisynthetic pentacyclic triterpenoids in the cancer setting: Ursolic acid and its derivatives". 2011.
  12. R. Salvador, Jorge A.; M., Vania. "Highlights of Natural Products in Prostate Cancer Drug Discovery". In Prostate Cancer - From Bench to Bedside. InTech, 2011.
    10.5772/27401
  13. Salvador, J. A. R.; Silvestre, S. M.; Pinto, R. M. A.; Santos, R. C.; LeRoux, C.. "New Applications for Bismuth(III) Salts in Organic Synthesis: From Bulk Chemicals to Steroid and Terpene Chemistry". In Bismuth-Mediated Organic Reactions, 143-177. Springer Berlin Heidelberg, 2011.
    10.1007/128_2011_170
  14. Salvador, J.A.R.; Moreira, V.M.. "Natural products action on prostate cancer cell growth, signaling and survival". 2009.
  15. Jorge A. R. Salvador; Sá e Melo, M.L.; Campos Neves A. S.. "A New Clemmensen Reduction”, Preparation of 5a-Androstan-17ß-ol from 5a-Androstan-17ß-ol-3-one,". Plenum Press, 1998.
Conference paper
  1. J.Sousa; R. Brito; Jorge A R Salvador; C. Silva. "In Search of Predictive Models for Inibitors of 5-a-reductase 2". Paper presented in Proceedings, IWBBIO, 2014.
  2. Leal, Ana S.; Salvador, Jorge A.R.; Yongkui, Jing. "Abstract A23: Novel ursolic acid derivatives with potent antitumor activity". Paper presented in AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations, Boston, 2012.
    10.1158/1538-7445.csb12-a23
  3. Leal, Ana S.; Salvador, Jorge; Jing, Yongkui. "Abstract 4234: Ursolic acid induces apoptosis in pancreatic cancer cells associated with inhibition of STAT3 and down-regulation of Bcl-XL". 2011.
    10.1158/1538-7445.am2011-4234
  4. Moreira, V.M.A.; Jorge A.R.Salvador; Sá e Melo, M.L.; Hanson, J. R.; Marques, A.; Simões, S.. "New 5b,6b-epoxysteroids with cytotoxic activity". 2005.
  5. Salvador, J. A. R.; Sá e Melo, M.L.; Campos Neves, A. S.. "Ultrasound Assisted Oxidations with Potassium Permanganate on Solids Supports". Paper presented in 1995 World Congress of Ultrasonics, Berlin, 1995.
Journal article
  1. Gonçalves, Ângela; Matias, Mariana; Salvador, Jorge A. R.; Silvestre, Samuel. "Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?". International Journal of Molecular Sciences 25 3 (2024): 1600. http://dx.doi.org/10.3390/ijms25031600.
    10.3390/ijms25031600
  2. Fernandes, Pedro M. P.; Guedes, Romina A.; Victor, Bruno L.; Salvador, Jorge A. R.; Guedes, Rita C.. "Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome". Frontiers in Chemistry 11 (2024): http://dx.doi.org/10.3389/fchem.2023.1322628.
    10.3389/fchem.2023.1322628
  3. Vicente, André T. S.; Salvador, Jorge A. R.. "PROteolysis-TArgeting Chimeras (PROTACs) in Leukemia: Overview and Future Perspectives". MedComm (2024):
    In press
  4. Olha Antoniuk; Ana Maranha; Jorge A. R. Salvador; Nuno Empadinhas; Vânia M. Moreira. "Bi- and tricyclic diterpenoids. Landmarks from a decade (2013-2023) in search of leads against infectious diseases". Natural Product Reports (2024):
    Under revision
  5. Jorge A. R. Salvador. "BACE1 Inhibitors for Alzheimer’s Disease: Current Challenges and Future Perspectives". Journal of Alzheimer’s Disease (2024):
    In press
  6. Pereira, Tiago O.; Abbasi, Maryam; Oliveira, Rita I.; Guedes, Romina A.; Salvador, Jorge A. R.; Arrais, Joel P.. "Artificial intelligence for prediction of biological activities and generation of molecular hits using stereochemical information". Journal of Computer-Aided Molecular Design 37 12 (2023): 791-806. http://dx.doi.org/10.1007/s10822-023-00539-9.
    10.1007/s10822-023-00539-9
  7. Carreira, Laura D.; Oliveira, Rita I.; Moreira, Vânia M.; Salvador, Jorge A. R.. "Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment". Expert Opinion on Therapeutic Targets 27 11 (2023): 1043-1058. http://dx.doi.org/10.1080/14728222.2023.2266571.
    10.1080/14728222.2023.2266571
  8. Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R.. "Therapeutic potential of glutaminyl cyclases: Current status and emerging trends". Drug Discovery Today 28 10 (2023): 103644. http://dx.doi.org/10.1016/j.drudis.2023.103644.
    10.1016/j.drudis.2023.103644
  9. Guedes, Romina A.; Grilo, Jorge H.; Carvalho, Andreia N.; Fernandes, Pedro M. P.; Ressurreição, Ana S.; Brito, Vanessa; Santos, Adriana O.; et al. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals 16 8 (2023): 1096. http://dx.doi.org/10.3390/ph16081096.
    10.3390/ph16081096
  10. André T. S. Vicente; Jorge A. R. Salvador, Salvador, J.. Corresponding author: Jorge A. R. Salvador, Salvador, J.. "Proteolysis-Targeting Chimeras (PROTACs) targeting the BCR-ABL for the treatment of Chronic Myeloid Leukemia – A Patent Review". Expert Opinion On Therapeutic Patents (2023): 397-420. https://doi.org/10.1080/13543776.2023.2240025.
    Published
  11. Sobral, Pedro J. M.; Vicente, André T. S.; Salvador, Jorge A. R.. "Recent advances in oridonin derivatives with anticancer activity". Frontiers in Chemistry 11 (2023): http://dx.doi.org/10.3389/fchem.2023.1066280.
    10.3389/fchem.2023.1066280
  12. Gonçalves, Bruno M. F.; Mendes, Vanessa I. S.; Silvestre, Samuel M.; Salvador, Jorge A. R.. "Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents". RSC Medicinal Chemistry (2023): http://dx.doi.org/10.1039/d2md00275b.
    10.1039/d2md00275b
  13. Vicente, André T. S.; Salvador, Jorge A. R.. "MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment". International Journal of Molecular Sciences 23 19 (2022): 11068. http://dx.doi.org/10.3390/ijms231911068.
    10.3390/ijms231911068
  14. Oliveira, Rita I.; Guedes, Romina A.; Salvador, Jorge A. R.. "Highlights in USP7 inhibitors for cancer treatment". Frontiers in Chemistry 10 (2022): http://dx.doi.org/10.3389/fchem.2022.1005727.
    10.3389/fchem.2022.1005727
  15. Pereira, Tiago; Abbasi, Maryam; Oliveira, Rita I; Guedes, Romina A; Salvador, Jorge A R; Arrais, Joel P. "Deep generative model for therapeutic targets using transcriptomic disease-associated data—USP7 case study". Briefings in Bioinformatics 23 4 (2022): http://dx.doi.org/10.1093/bib/bbac270.
    10.1093/bib/bbac270
  16. Acúrcio, Rita C.; Pozzi, Sabina; Carreira, Barbara; Pojo, Marta; Gómez-Cebrián, Nuria; Casimiro, Sandra; Fernandes, Adelaide; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment". Journal for ImmunoTherapy of Cancer 10 7 (2022): e004695. http://dx.doi.org/10.1136/jitc-2022-004695.
    10.1136/jitc-2022-004695
  17. Leonardo-Sousa, Carlota; Carvalho, Andreia Neves; Guedes, Romina A.; Fernandes, Pedro M. P.; Aniceto, Natália; Salvador, Jorge A. R.; Gama, Maria João; Guedes, Rita C.. "Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance". Molecules 27 7 (2022): 2201. http://dx.doi.org/10.3390/molecules27072201.
    10.3390/molecules27072201
  18. Coimbra, Judite R.M.; Salvador, Jorge A.R.. "A patent review of glutaminyl cyclase inhibitors (2004–present)". Expert Opinion on Therapeutic Patents 31 9 (2021): 809-836. http://dx.doi.org/10.1080/13543776.2021.1917549.
    10.1080/13543776.2021.1917549
  19. Kok, Victor C.; Yu, Cheng-Chia; Salvador, Jorge A.R.. "Editorial: Head & Neck Cancer and Esophageal Cancer: From Biosignatures to Therapeutics". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.666103.
    Open access • Published • 10.3389/fonc.2021.666103
  20. Rui Moreira; M. Matilde Marques; Emília Sousa; Madalena Pinto; Jorge Salvador. "Glossário de Termos Usados em Química Medicinal". Boletim da Sociedade Portuguesa de Química (2020): 35. http://dx.doi.org/10.52590/m3.p693.a30002302.
    10.52590/m3.p693.a30002302
  21. Gütschow, Michael; Vanden Eynde, Jean Jacques; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; et al. "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes 7". Molecules 25 13 (2020): 2968. http://dx.doi.org/10.3390/molecules25132968.
    10.3390/molecules25132968
  22. Resende, Rosa; Ferreira-Marques, Marisa; Moreira, Patrícia; Coimbra, Judite R.M.; Baptista, Salete J.; Isidoro, Ciro; Salvador, Jorge A.R.; et al. "New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AßPPß Cleavage Decreasing Amyloid-ß Production and Accumulation in Alzheimer’s Disease Models". Journal of Alzheimer's Disease (2020): 1-21. http://dx.doi.org/10.3233/jad-200381.
    10.3233/jad-200381
  23. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  24. Pinto, Patricia; Machado, Carmen Mariana; Moreira, Joana; Almeida, José Diogo P.; Silva, Patrícia M.A.; Henriques, Ana C.; Soares, José X.; et al. "Chalcone derivatives targeting mitosis: synthesis, evaluation of antitumor activity and lipophilicity". European Journal of Medicinal Chemistry 184 (2019): 111752. http://dx.doi.org/10.1016/j.ejmech.2019.111752.
    10.1016/j.ejmech.2019.111752
  25. Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://dx.doi.org/10.4155/fmc-2019-0163.
    10.4155/fmc-2019-0163
  26. Guedes, R.; Aniceto; Andrade; Salvador, J.A.R.. "Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design". International Journal of Molecular Sciences 20 21 (2019): 5326. http://dx.doi.org/10.3390/ijms20215326.
    10.3390/ijms20215326
  27. Alho, Daniela P.S.; Salvador, Jorge A.R.; Cascante, Marta; Marin, Silvia. "Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives". Molecules 24 16 (2019): 2938. http://dx.doi.org/10.3390/molecules24162938.
    10.3390/molecules24162938
  28. Valdeira, Ana S. C.; Darvishi, Emad; Woldemichael, Girma M.; Beutler, John A.; Gustafson, Kirk R.; Salvador, Jorge A. R.. "Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation". Journal of Natural Products 82 8 (2019): 2094-2105. http://dx.doi.org/10.1021/acs.jnatprod.8b00864.
    10.1021/acs.jnatprod.8b00864
  29. Alho, Daniela; Salvador, Jorge; Cascante, Marta; Marin, Silvia. "Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives". Molecules 24 4 (2019): 766. http://dx.doi.org/10.3390/molecules24040766.
    10.3390/molecules24040766
  30. Acúrcio, Rita C.; Leonardo-Sousa, Carlota; García-Sosa, Alfonso T.; Salvador, Jorge A.; Florindo, Helena F.; Guedes, Rita C.. "Structural insights and binding analysis for determining the molecular bases for programmed cell death protein ligand-1 inhibition". MedChemComm 10 10 (2019): 1810-1818. http://dx.doi.org/10.1039/c9md00326f.
    10.1039/c9md00326f
  31. Valdeira, Ana S. C.; Ritt, Daniel A.; Morrison, Deborah K.; McMahon, James B.; Gustafson, Kirk R.; Salvador JAR (1112-4DB1-C082). "Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00434.
    10.3389/fchem.2018.00434
  32. Acúrcio, Rita C.; Scomparin, Anna; Conniot, João; Salvador, Jorge A. R.; Satchi-Fainaro, Ronit; Florindo, Helena F.; Guedes, Rita C.. "Structure–Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy". Journal of Medicinal Chemistry 61 24 (2018): 10957-10975. http://dx.doi.org/10.1021/acs.jmedchem.8b00541.
    10.1021/acs.jmedchem.8b00541
  33. Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia M. F.; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.; Salvador, Jorge A. R.. "Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment". Frontiers in Chemistry 6 (2018): http://dx.doi.org/10.3389/fchem.2018.00178.
    10.3389/fchem.2018.00178
  34. Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.. "Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach". PLOS ONE 12 1 (2017): e0170846. http://dx.doi.org/10.1371/journal.pone.0170846.
    10.1371/journal.pone.0170846
  35. Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M.. "Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation". European Journal of Medicinal Chemistry 138 (2017): 422-437. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021775494&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.06.029
  36. Salvador, J.A.R.; Leal, A.S.; Valdeira, A.S.; Gonçalves, B.M.F.; Alho, D.P.S.; Figueiredo, S.A.C.; Silvestre, S.M.; Mendes, V.I.S.. "Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment". European Journal of Medicinal Chemistry 142 (2017): 95-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025822828&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.07.013
  37. Figueiredo, S.A.C.; Salvador, J.A.R.; Cortés, R.; Cascante, M.. "Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds". European Journal of Medicinal Chemistry 139 (2017): 836-848. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028462538&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.08.058
  38. Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R.. "Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells". European Journal of Medicinal Chemistry 123 (2016): 317-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979776393&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.07.045
  39. Gonçalves, B.M.F.; Salvador, J.A.R.; Santos, D.S.M.; Marín, S.; Cascante, M.. "Design, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents". RSC Advances 6 45 (2016): 39296-39309. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968807179&partnerID=MN8TOARS.
    10.1039/c6ra04597a
  40. Mendes, V.I.S.; Bartholomeusz, G.A.; Ayres, M.; Gandhi, V.; Salvador, J.A.R.. "Erratum: Corrigendum to “Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells” (European Journal of Medicinal Chemistry (2016) 123 (317–331) (S0223523416306067) (10.1016/j.ejmech.2016.07.045))". European Journal of Medicinal Chemistry 124 (2016): 1004-1005. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992431127&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.09.088
  41. Guedes, R.A.; Serra, P.; Salvador, J.A.R.; Guedes, R.C.. "Computational approaches for the discovery of human proteasome inhibitors: An overview". Molecules 21 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84979205213&partnerID=MN8TOARS.
    10.3390/molecules21070927
  42. Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity". RSC Advances 6 5 (2016): 3967-3985. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954305589&partnerID=MN8TOARS.
    10.1039/c5ra19120c
  43. Gonçalves, B.M.F.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives". European Journal of Medicinal Chemistry 114 (2016): 101-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964200014&partnerID=MN8TOARS.
    10.1016/j.ejmech.2016.02.057
  44. Salvador, Jorge; Pinto, Rui; Silvestre, Samuel. "Pharmaceutical Green Chemistry Applied to the Chemical Synthesis of Steroid Compounds". Current Green Chemistry 2 2 (2015): 97-134. http://dx.doi.org/10.2174/2213346101666140915212302.
    10.2174/2213346101666140915212302
  45. Mesquita, L.M.M.; Pinto, R.M.A.; Salvador, J.A.R.; Clark, J.H.; Budarin, V.L.. "Starbon®400-HSO3: A green mesoporous carbonaceous solid acid catalyst for the Ritter reaction". Catalysis Communications 69 (2015): 170-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933040279&partnerID=MN8TOARS.
    10.1016/j.catcom.2015.06.010
  46. Lopes, S.M.M.; Correia, C.F.O.; Nunes, S.C.C.; Pereira, N.A.M.; Ferreira, A.R.F.; Sousa, E.P.; Gomes, C.S.B.; et al. "Synthesis of chiral hexacyclic steroids via [8p + 2p] cycloaddition of diazafulvenium methides". Organic and Biomolecular Chemistry 13 34 (2015): 9127-9139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939605321&partnerID=MN8TOARS.
    10.1039/c5ob01110h
  47. Sousa, M.C.; Varandas, R.; Santos, R.C.; Santos-Rosa, M.; Alves, V.; Salvador, J.A.R.. "Antileishmanial activity of semisynthetic lupane triterpenoids betulin and betulinic acid derivatives: Synergistic effects with miltefosine". PLoS ONE 9 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84898670704&partnerID=MN8TOARS.
    10.1371/journal.pone.0089939
  48. Salvador, J.A.R.; Santos, R.C.; Figueiredo, S.A.C.; Jing, Y.. "Antitumor effects of celastrol and semi-synthetic derivatives". Mini-Reviews in Organic Chemistry 11 3 (2014): 400-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911413424&partnerID=MN8TOARS.
  49. Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L.. "Anticancer steroids: Linking natural and semi-synthetic compounds". Natural Product Reports 30 2 (2013): 324-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS.
    10.1039/c2np20082a
  50. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Synthesis of novel heterocyclic oleanolic acid derivatives with improved antiproliferative activity in solid tumor cells". Organic and Biomolecular Chemistry 11 10 (2013): 1726-1738. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874077386&partnerID=MN8TOARS.
    10.1039/c3ob00011g
  51. Moreira, V.M.; Salvador, J.A.R.; Simões, S.; Destro, F.; Gavioli, R.. "Novel oleanolic vinyl boronates: Synthesis and antitumor activity". European Journal of Medicinal Chemistry 63 (2013): 46-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878527939&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.01.040
  52. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Steroidal 5a-reductase and 17a-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases". Journal of Steroid Biochemistry and Molecular Biology 137 (2013): 199-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886716946&partnerID=MN8TOARS.
    10.1016/j.jsbmb.2013.04.006
  53. Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Paixão, J.A.. "Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives". Beilstein Journal of Organic Chemistry 8 (2012): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856902762&partnerID=MN8TOARS.
    10.3762/bjoc.8.17
  54. Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.; Santos, R.C.; Leroux, C.. "New applications for bismuth(III) salts in organic synthesis: From bulk chemicals to steroid and terpene chemistry". Topics in Current Chemistry 311 (2012): 143-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856185934&partnerID=MN8TOARS.
    10.1007/128_2011_170
  55. Salvador, J.A.; Moreira, V.M.; Gonçalves, B.M.; Leal, A.S.; Jing, Y.. "Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.". Natural product reports 29 12 (2012): 1463-1479. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872769330&partnerID=MN8TOARS.
  56. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Recent developments in oxidative processes in steroid chemistry". Current Organic Chemistry 16 10 (2012): 1243-1276. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861178831&partnerID=MN8TOARS.
    10.2174/138527212800564204
  57. Salvador, J.A.; Figueiredo, S.A.; Pinto, R.M.; Silvestre, S.M.. "Bismuth compounds in medicinal chemistry". Future Medicinal Chemistry 4 11 (2012): 1495-1523. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864659112&partnerID=MN8TOARS.
    10.4155/fmc.12.95
  58. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells". ChemMedChem 7 9 (2012): 1635-1646. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865591129&partnerID=MN8TOARS.
    10.1002/cmdc.201200282
  59. Leal, A.S.; Wang, R.; Salvador, J.A.R.; Jing, Y.. "Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells". Bioorganic and Medicinal Chemistry 20 19 (2012): 5774-5786. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866355871&partnerID=MN8TOARS.
    10.1016/j.bmc.2012.08.010
  60. Moreira, V.M.A.; Salvador, J.A.R.; Matos Beja, A.; Paixão, J.A.; Vasaitis, T.S.; Njar, V.C.O.. "C16 and C17-heterocycle bearing androstanes. CYP17 inhibition studies and multiple effects on prostate cancer cells". European Journal of Pharmaceutical Sciences 44 (2011): 1-204. http://dx.doi.org/10.1016/j.ejps.2011.08.002.
    10.1016/j.ejps.2011.08.002
  61. Santos, R.C.; Salvador, J.A.R.; Cortés, R.; Pachón, G.; Marín, S.; Cascante, M.. "New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells". Biochimie 93 6 (2011): 1065-1075. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955054133&partnerID=MN8TOARS.
    10.1016/j.biochi.2011.02.014
  62. Salvador, J.A.R.; Moreira, V.M.; Pinto, R.M.A.; Leal, A.S.; Le Roux, C.. "Bismuth(III) triflate-based catalytic direct opening of oleanolic hydroxy-¿-lactones to afford 12-oxo-28-carboxylic acids". Advanced Synthesis and Catalysis 353 14-15 (2011): 2637-2642. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054739831&partnerID=MN8TOARS.
    10.1002/adsc.201100155
  63. Salvador, J.A.R.; Silvestre, S.M.; Pinto, R.M.A.. "Bismuth(III) reagents in steroid and terpene chemistry". Molecules 16 4 (2011): 2884-2913. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955528110&partnerID=MN8TOARS.
    10.3390/molecules16042884
  64. Moreira, V.M.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.. "The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3ß- yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17- oxoandrostanes". Steroids 76 6 (2011): 582-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954588573&partnerID=MN8TOARS.
    10.1016/j.steroids.2011.02.009
  65. Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3-Oxo-18a-olean-28,13ß-olide". Acta Crystallographica Section E: Structure Reports Online 66 8 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956829330&partnerID=MN8TOARS.
    10.1107/S160053681002903X
  66. Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3¿-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate". Acta Crystallographica Section E: Structure Reports Online 66 11 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78650948724&partnerID=MN8TOARS.
    10.1107/S1600536810043515
  67. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P.. "Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Bioorganic and Medicinal Chemistry 18 12 (2010): 4385-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.04.085
  68. Santos, R.C.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "3ß-Hydroxylup-20(29)-en-28-yl 1H-imidazole-1-carboxylate". Acta Crystallographica Section E: Structure Reports Online 66 7 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954408228&partnerID=MN8TOARS.
    10.1107/S160053681002489X
  69. Moreira, V.M.; Salvador, J.A.R.. "The Multiple Effects of CYP17 Inhibitors on Prostate Cancer Cell.". Drugs of the Future 35 (2010): 71-72.
    10.1177/1758834016642370
  70. Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta; Moreira, João N.; Dinis, Teresa C.P.. "Synthesis and structure–activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Drugs of the Future 35 (2010): 240-241. http://dx.doi.org/10.1016/j.bmc.2010.04.085.
    10.1016/j.bmc.2010.04.085
  71. Santos, Rita C.; Salvador, Jorge A.R.; Marín, Silvia; Cascante, Marta. "Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity". Drugs of the Future 35 (2010): 246-247. http://dx.doi.org/10.1016/j.bmc.2009.07.050.
    10.1016/j.bmc.2009.07.050
  72. Salvador, J.A.R.; Pinto, R.M.A.; Santos, R.C.; Le Roux, C.; Beja, A.M.; Paixão, J.A.. "Bismuth triflate-catalyzed Wagner-Meerwein rearrangement in terpenes. Application to the synthesis of the 18a-oleanane core and A-neo-18a-oleanene compounds from lupanes". Organic and Biomolecular Chemistry 7 3 (2009): 508-517. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849131044&partnerID=MN8TOARS.
    10.1039/b814448f
  73. Ramos Silva, M.; Moreira, V.M.; Cardoso, C.; Beja, A.M.; Salvador, J.A.R.. "3-Oxoandrosta-4,6-dien-17ß-yl 2-methyl-1H-imidazole-1-carboxylate and 3-oxo-5-androst-17ß-yl 2-methyl-1H-imidazole-1-carboxyl-ate: C - H¿p and p-p Inter-molecular interactions". Acta Crystallographica Section C: Crystal Structure Communications 65 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-62149118592&partnerID=MN8TOARS.
    10.1107/S0108270109003278
  74. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "6¿-Hydr-oxy-5¿-methyl-20-oxo-19-norpregn-9(10)-en-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 65 5 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-65549162802&partnerID=MN8TOARS.
    10.1107/S0108270109010233
  75. Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "16,17-Ep-oxy-5-hydr-oxy-6¿-nitrooxy-20-oxopregnan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 65 6 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67649854870&partnerID=MN8TOARS.
    10.1107/S1600536809016997
  76. Salvador, J.A.R.; Ppinto, R.M.A.; Silvestre, S.M.. "Recent advances of bismuth(III) salts in organic chemistry: Application to the synthesis of aliphatics, alicyclics, aromatics, amino acids and peptides, terpenes and steroids of pharmaceutical interest". Mini-Reviews in Organic Chemistry 6 4 (2009): 241-274. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350227226&partnerID=MN8TOARS.
    10.2174/157019309789371587
  77. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Paixão, J.A.. "Bismuth(III) triflate-catalyzed direct conversion of corticosteroids into highly functionalized 17-ketosteroids by cleavage of the C17-dihydroxyacetone side chain". Journal of Organic Chemistry 74 21 (2009): 8488-8491. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350736011&partnerID=MN8TOARS.
    10.1021/jo9018478
  78. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Beja, A.M.; Paixão, J.A.. "Bismuth(III) triflate-catalyzed rearrangement of 16a,17a-epoxy-20-oxosteroids. Synthesis and structural elucidation of new 16a-substituted 17a-alkyl-17ß-methyl-¿13-18-norsteroids". Tetrahedron 65 31 (2009): 6169-6178. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649513263&partnerID=MN8TOARS.
    10.1016/j.tet.2009.05.043
  79. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.. "Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity". Bioorganic and Medicinal Chemistry 17 17 (2009): 6241-6250. http://www.scopus.com/inward/record.url?eid=2-s2.0-68649104244&partnerID=MN8TOARS.
    10.1016/j.bmc.2009.07.050
  80. Santos, R.C.; Pinto, R.M.A.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "19¿,28-Epoxy-18a-olean-3¿-ol". Acta Crystallographica Section E: Structure Reports Online 65 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70249125089&partnerID=MN8TOARS.
    10.1107/S1600536809030311
  81. Salvador, J.A.R.; Pinto, R.M.A.; Silvestre, S.M.. "Recent advances of nismuth(III) salts in organic chemistry: Application to the synthesis of heterocycles of pharmaceutical interest". Current Organic Synthesis 6 4 (2009): 426-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350110620&partnerID=MN8TOARS.
    10.2174/157017909789108701
  82. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Catalytic epoxidation and syn-dihydroxylation reactions in steroid chemistry". Current Organic Chemistry 12 6 (2008): 492-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-44449108043&partnerID=MN8TOARS.
    10.2174/138527208784083897
  83. Moreira, V.M.; Salvador, J.A.R.; Vasaitis, T.S.; Njar, V.C.O.. "CYP17 inhibitors for prostate cancer treatment - An update". Current Medicinal Chemistry 15 9 (2008): 868-899. http://www.scopus.com/inward/record.url?eid=2-s2.0-44349099797&partnerID=MN8TOARS.
    10.2174/092986708783955428
  84. Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.. "5¿,6¿-Ep-oxy-17-oxoandrostan-3¿-yl acetate and 5¿,6¿-ep-oxy-20-oxo-pregnan-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 64 5 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-43149091878&partnerID=MN8TOARS.
    10.1107/S0108270108009621
  85. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.; Carvalho, R.A.; Silva, M.R.; Beja, A.M.; Paixão, J.A.. "Bismuth(III) salt-catalyzed Westphalen and "backbone" rearrangements of 5ß,6ß-epoxysteroids. Synthesis and structural elucidation of new olefinic 19-nor and 18,19-dinorsteroids". Steroids 73 5 (2008): 549-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649099519&partnerID=MN8TOARS.
    10.1016/j.steroids.2008.01.006
  86. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Metal triflates combined with caffeine based imidazolium salts: A new family of highly efficient and reusable catalysts". Catalysis Communications 9 3 (2008): 465-469. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549069243&partnerID=MN8TOARS.
    10.1016/j.catcom.2007.07.022
  87. Leitão, A.J.L.; Salvador, J.A.R.; Pinto, R.M.A.; Sá e Melo, M.L.. "Hydrazine sulphate: a cheap and efficient catalyst for the regioselective ring-opening of epoxides. A metal-free procedure for the preparation of ß-alkoxy alcohols". Tetrahedron Letters 49 10 (2008): 1694-1697. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949187114&partnerID=MN8TOARS.
    10.1016/j.tetlet.2007.12.121
  88. Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R.. "1H-Indazole and 2H-indazole derivatives of androsta-5,16-dien-3¿-ol". Acta Crystallographica Section C: Crystal Structure Communications 64 4 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-41849150404&partnerID=MN8TOARS.
    10.1107/S0108270108005842
  89. Pinto, R.M.A.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.. "6¿-Chloro-5-hydroxy-20-oxopregnan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 64 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-49149110097&partnerID=MN8TOARS.
    10.1107/S1600536808019478
  90. Silva, M.R.; Moreira, V.M.; Cardoso, C.; Matos Beja, A.; Salvador, J.A.R.. "Conformation of 17-chloro-16-formylandrosta-5,16-dien-3¿-yl acetate and 17-chloroandrosta-5,16-dien-3¿-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 64 9 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-51049095681&partnerID=MN8TOARS.
    10.1107/S0108270108025997
  91. Moreira, V.M.A.; Vasaitis, T.S.; Guo, Z.; Njar, V.C.O.; Salvador, J.A.R.. "Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth". Steroids 73 12 (2008): 1217-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-50249167090&partnerID=MN8TOARS.
    10.1016/j.steroids.2008.05.010
  92. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "6¿-Acetamido-5-hydroxy-cholestan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 64 12 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-57349122293&partnerID=MN8TOARS.
    10.1107/S160053680803568X
  93. Sanros R. C.; Cascante, M.; Salvador, J.A.R.. "Synthesis and Evaluation of Cytotoxic Activity of Novel Synthetic Lupane Derivatives". Drugs of the Future 33 (2008): 164.
    10.7324/rjc.2017.1041914
  94. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.; Paixão, J.A.. "5a-Acetamido-6¿-hydroxy-17-oxoandrostan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 63 7 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547204638&partnerID=MN8TOARS.
    10.1107/S1600536807029893
  95. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Bismuth(III) salts mediated regioselective ring opening of epoxides: an easy route to halohydrins and ß-hydroxy nitrates". Tetrahedron 63 37 (2007): 9221-9228. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547515937&partnerID=MN8TOARS.
    10.1016/j.tet.2007.06.054
  96. Ramos Silva, M.; Matos Beja, A.; Moreira, V.M.; Santos, R.C.; Salvador, J.A.R.. "3-Oxoandrost-4-en-17¿-yl 1H-imidazole-1-carboxyl-ate". Acta Crystallographica Section E: Structure Reports Online 63 12 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-36849032339&partnerID=MN8TOARS.
    10.1107/S1600536807057625
  97. Moreira, V.M.A.; Vasaitis, T.S.; Njar, V.C.O.; Salvador, J.A.R.. "Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors". Steroids 72 14 (2007): 939-948. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349005731&partnerID=MN8TOARS.
    10.1016/j.steroids.2007.08.004
  98. Silvestre, S.M.; Salvador, J.A.R.. "Allylic and benzylic oxidation reactions with sodium chlorite". Tetrahedron 63 11 (2007): 2439-2445. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846804403&partnerID=MN8TOARS.
    10.1016/j.tet.2007.01.012
  99. Pinto, R.M.A.; Ramos Silva, M.; Matos Beja, A.; Salvador, J.A.R.. "5,6¿-Dihydroxy-cholestan-3¿-yl acetate". Acta Crystallographica Section E: Structure Reports Online 63 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-40649129062&partnerID=MN8TOARS.
    10.1107/S1600536807014705
  100. Salvador, J.A.R.; Moreira, V.M.; Hanson, J.R.; Carvalho, R.A.. "One-pot, high yield synthesis of a-ketols from ¿5- steroids". Steroids 71 3 (2006): 266-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-32144460142&partnerID=MN8TOARS.
    10.1016/j.steroids.2005.11.002
  101. Pinto, R.M.A.; Salvador, J.A.R.; Le Roux, C.. "Ritter reaction mediated by bismuth(III) salts: One-step conversion of epoxides into vic-acylamino-hydroxy compounds". Synlett 13 (2006): 2047-2050. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748278524&partnerID=MN8TOARS.
    10.1055/s-2006-949608
  102. Salvador, J.A.R.; Silvestre, S.M.; Moreira, V.M.. "Catalytic oxidative processes in steroid chemistry: Allylic oxidation, ß-Selective expoxidation, alcohol oxidation and remote functionalization reactions". Current Organic Chemistry 10 17 (2006): 2227-2257. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750593724&partnerID=MN8TOARS.
    10.2174/138527206778742641
  103. Moreira, V.M.A.; Salvador, J.A.R.; Sá e Melo, M.L.; Hanson, J.R.; Marques, A.; Simões, S.. "New 5b,6b-epoxysteroids with cytotoxic activity". Sci. Pharm. 73 8 (2005): 86.
  104. Salvador, J.A.R.; Leitão, A.J.L.; Sá E Melo, M.L.; Hanson, J.R.. "Hydrazine hydrate induced reductive cleavage of a,ß-epoxy ketones: An efficient procedure for the preparation of ß-hydroxy ketones". Tetrahedron Letters 46 7 (2005): 1067-1070. http://www.scopus.com/inward/record.url?eid=2-s2.0-12344252059&partnerID=MN8TOARS.
    10.1016/j.tetlet.2004.12.103
  105. Salvador, J.A.R.; Silvestre, S.M.. "Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide". Tetrahedron Letters 46 15 (2005): 2581-2584. http://www.scopus.com/inward/record.url?eid=2-s2.0-15244343394&partnerID=MN8TOARS.
    10.1016/j.tetlet.2005.02.080
  106. Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Beja, A.M.; Silva, M.R.; Gonsalves, A.M.D'A.R.. "6ß-Azido-7a-hydroxy-17-oxo-5a-androstan-3ß-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 60 9 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-5144230345&partnerID=MN8TOARS.
    10.1107/S0108270104011989
  107. Silvestre, S.M.; Salvador, J.A.R.; Clark, J.H.. "ß-Selective epoxidation of ¿5-steroids by O 2 using surface functionalised silica supported cobalt catalysts". Journal of Molecular Catalysis A: Chemical 219 1 (2004): 143-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042797794&partnerID=MN8TOARS.
    10.1016/j.molcata.2004.04.034
  108. Paixão, J.I.F.; Salvador, J.A.R.; Paixão, J.A.; Matos Beja, A.; Ramos Silva, M.; Rocha Gonsalves, A.M.d'A.. "17-Oxo-5a-androst-6-en-3ß-yl acetate". Acta Crystallographica Section C: Crystal Structure Communications 60 1 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-1242265340&partnerID=MN8TOARS.
    10.1107/S0108270103026933
  109. Salvador, J.A.R.; Hanson, J.R.. "The solid-phase oxidation of steroidal alkenes with potassium permanganate and metal salts". Journal of Chemical Research 8 (2004): 513-516. http://www.scopus.com/inward/record.url?eid=2-s2.0-7644227114&partnerID=MN8TOARS.
  110. Paixão, J.I.F.; Salvador, J.A.R.; Gonsalves, A.M.d’A R.. "Synthesis of New Azidosteroids and Related Compounds as Potential Aromatase Inhibitors.". Drugs of the Future (2004): 225.
  111. Hanson, J.R.; Hitchcock, P.B.; Salvador, J.A.R.. "The conformation of the side chain of 21-alkylpregnanes". Journal of Chemical Research - Part S 9 (2003): 556-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787610&partnerID=MN8TOARS.
  112. Salvador, J.A.R.; Hanson, J.R.. "The role of metal salts in a solid phase ß-selective epoxidation of ¿5-steroids with potassium permanganate". Journal of Chemical Research - Part S 11 (2002): 576-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036867876&partnerID=MN8TOARS.
  113. Salvador, J.A.R.; Clark, J.H.. "The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using surface functionalised silica supported metal catalysts". Green Chemistry 4 4 (2002): 352-356. http://www.scopus.com/inward/record.url?eid=2-s2.0-57249085588&partnerID=MN8TOARS.
    10.1039/b201500p
  114. Freixa, Z.; Pereira, M.M.; Bayón, J.Carles; Silva, A.M.S.; Salvador, J.A.R.; Beja, A.M.; Paixão, J.A.; Ramos, M.. "Diastereoselective hydroformylation of ¿4-steroids with rhodium-phosphite catalysts". Tetrahedron Asymmetry 12 7 (2001): 1083-1087. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035826557&partnerID=MN8TOARS.
    10.1016/S0957-4166(01)00191-4
  115. Salvador, J.A.R.; Clark, J.H.. "The allylic oxidation of unsaturated steroids by tert-butyl hydroperoxide using homogeneous and heterogeneous cobalt acetate". Chemical Communications 1 (2001): 33-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035819394&partnerID=MN8TOARS.
  116. Campos Neves, A.S.; Sá E Melo, M.L.; Moreno, M.J.S.M.; Tavares Da Silva, E.J.; Salvador, J.A.R.; Da Costa, S.P.; Martins, R.M.L.M.. "Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity". Tetrahedron 55 11 (1999): 3255-3264. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033105263&partnerID=MN8TOARS.
    10.1016/S0040-4020(98)01138-7
  117. Salvador, J.A.R.; E Melo, M.L.Sá.; Campos Neves, A.S.. "Copper-catalysed allylic oxidation of ¿5-steroids by t-butyl hydroperoxide". Tetrahedron Letters 38 1 (1997): 119-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-0342276132&partnerID=MN8TOARS.
    10.1016/S0040-4039(96)02231-9
  118. Salvador, J.A.R.; Sá E Melo, M.L.; Campos Neves, A.S.. "Oxidations with potassium permanganate - Metal sulphates and nitrates. ß-selective epoxidation of ¿5-unsaturated steroids". Tetrahedron Letters 37 5 (1996): 687-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034598&partnerID=MN8TOARS.
    10.1016/0040-4039(95)02243-0
  119. Sáe Melo, M.L.; Moreno, M.J.S.M.; da Costa, S.C.P.; Salvador, J.A.R.; Neves, A.S.C.. "Ultrasound assisted oxidations and reductions in steroid synthesis". Ultrasonics - Sonochemistry 1 1 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-0028392619&partnerID=MN8TOARS.
    10.1016/1350-4177(94)90024-8
  120. Sáe Melo, M.L.; Moreno, M.J.S.M.; Pereira da Costa, S.C.; Salvador, J.A.R.; Campos Neves, A.S.. "SC21 ultrasound assisted reactions in steroid synthesis". European Journal of Pharmaceutical Sciences 2 1-2 (1994): http://www.scopus.com/inward/record.url?eid=2-s2.0-43949158790&partnerID=MN8TOARS.
    10.1016/0928-0987(94)90103-1
  121. Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S.. "Ultrasound assisted zinc reactions in synthesis. 1. Efficient reduction of enones". Tetrahedron Letters 34 2 (1993): 357-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027505351&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)60587-7
  122. Salvador, J.A.R.; Sa Melo, E.M.L.; Campos Neves, A.S.. "Ultrasound assisted zinc reactions in synthesis. 2. A new Clemmensen-type reduction". Tetrahedron Letters 34 2 (1993): 361-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027391706&partnerID=MN8TOARS.
    10.1016/S0040-4039(00)60588-9

Intellectual property

Patent
  1. Jorge A. R. Salvador; Rita Santos; Marta Cascante Serratosa. 2015. "Triterpenoid Derivatives Usefull as Antiproliferative Agents". United States.
  2. Jorge A. R. Salvador; Rita Santos; Marta Cascante Serratosa. 2012. "Derivados Triterpenóides úteis como agentes Antiproliferativos". Portugal.
  3. Jorge A. R. Salvador; Rita Santos; Marta Cascante. 2010. "Triterpenoid Derivatives and Their Use as Antiproliferative Agents".
  4. Jorge A. R. Salvador; Samuel M. Silvestre. 2009. "Processo para a Oxidação Alílica de Compostos Insaturados". Portugal.
  5. Jorge A. R. Salvador; Samuel M. Silvestre. 2008. "Processo para a Oxidação Alílica de Compostos Insaturados". Portugal.
  6. Jorge A. R. Salvador; Samuel M. Silvestre. 2006. "Processo para a Oxidação Alílica de Compostos Insaturados Usando Hidroperóxido de t-Butilo e Catalisadores de Bismuto". Portugal.
  7. Clark, J.H.; Jorge A. R. Salvador. 2002. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide". Australia.
  8. CLARK, J.H; Jorge A. R. Salvador. 2002. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide".
  9. CLARK, J.H; Jorge A. R. Salvador. 2001. "Cobalt Catalysed Allylic Oxidation of Unsaturated Steroids Using Alkyl Hydroperoxide". United Kingdom.
  10. Jorge A.R.Salvador; M Luisa Sá e Melo; André S. Campos Neves. 2001. "Copper-Catalysed Allylic Oxidation Using Alkyl Hydroperoxide". United States.
    Granted/Issued
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2022/10/01 - Current Natural product-based anticancer agents for inhibition of USP7
Supervisor
Ciências Farmacêuticas-Química Farmacêutica (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/09/01 - Current New inhibitors of ubiquitin-specific protease 7 (USP7) as anticancer drugs
Supervisor
Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/10/01 - Current Preparation of novel fluorinated ent-kaurane-type diterpenoid derivatives and evaluation of their antiproliferative activity.
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/10/01 - Current Exploring the discovery of dual proteasome and CRM1 inhibitors in anticancer therapy
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/10/01 - Current Novel abietane-type diterpenoid derivatives with potent anticancer activity
Supervisor
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/10/01 - Current Rational Drug Design of Novel Potent multifunctional Agents for Alzheimer´s Disease Treatment
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2019/12/17 Targeting the proteasome in anticancer therapy by a computational based drug discovery approach
Co-supervisor
Pharmacy: sub-area Therapeutic and Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/10/01 - 2019/12/16 Discovery and development of novel small-molecule imune system modulators
Co-supervisor
Pharmacy: sub-area Therapeutic and Pharmaceutical Chemistry (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011/11/01 - 2019/12/11 Preparation and preclinical evaluation of new ursane-type triterpenoids
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2011/10/01 - 2018/06/12 Rational design, synthesis and evaluation of novel anticancer chemopotentiators acting on DNA-repair pathways
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2012/10/01 - 2017/12/19 Pentacyclic Triterpenoids: Discovery of New Drugs with Antitumour Activity
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2014/10/01 - 2017/03/03 Preparation of New Bioactive Flavonoids Derivatives
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 New Chiral Steroid Derivatives Through (8p+2p)” Cycloaddition Reactions of 1,2 Diazafulvenium Methines,
Supervisor
Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 Designing and Preparation of New BACE1 Inhibitors for Alzheimer´s Disease Treatment
Supervisor
Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2017/03/03 Síntese de Triterpenóides Fluorados
Supervisor
Química Farmacêutica Industrial (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/11/01 - 2016/11/24 Preparation and Pre-clinical Evaluation of New Pentacyclic Triterpenoids
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2010/11/01 - 2016/11/24 Preparação e avaliação pré-clínica de novos compostos triterpenóides.
Supervisor
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra, Portugal
2014/10/01 - 2016/10/20 Synthesis of Bioactive Chalcones and their Heterocyclic Derivatives as Potential Antitumor Agents
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2014/10/01 - 2016/10/20 Synthesis of Marine Xanthones : tracking Yicathins B and C
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013/10/01 - 2016/10/01 Síntese de derivados semi-sintéticos do ácido oleanólico com vista à actividade antitumoral
Supervisor
Medicinal Chemistry (Master)
Universidade de Coimbra, Portugal
2014/10/01 - 2016/09/03 Análise de Fitoquímicos em geranium Robertianum L
Co-supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2015/07/28 Preparação de Triterpenóides e Avaliação da Atividade Antiparasitária em Tripanossomatideo leishmania infantum
Co-supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/11/01 - 2015 Preparação e avaliação anti-tumoral de novos triterpenóides de núcleo oleanano
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2012/10/01 - 2014/10/14 Study of the Impact of Pollutant Compounds and Oxidative Stress in Human Health
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/30 Preparação de Novos derivados de Esteróides através de Cicloadição [8p+2p] de aniões 1,2 Diazafulvénio
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/30 Prospecção e Obtenção de Compostos com Potencial Terapêutico, a partir de Subprodutos Industriais
Co-supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2012/10/01 - 2014/09/29 Comparação de Métodos de Fingerprints para o Rastreio Virtual de inhibidores da 5a-Redutase
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/31 Modificações Estruturais em Compostos Triterpenóides
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/15 Preparação de Novos Derivados Esteróides via Reações de Cicloadições Dipolares
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/10/15 Novos Processos de Fluoração em Química Farmacêutica Industrial
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2011/10/01 - 2013/10/14 Rastreio Virtual na Descoberta de Possíveis Inibidores da 5-a-Redutase
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/09/17 Virtual Screening e Avaliação Biológica de Novos Inibidores do Proteassoma
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2007/11/01 - 2013/02/19 Preparação e avaliação pré-clínica de novos triterpenos derivados dos ácidos oleanólico e ursólico
Supervisor
Pharmaceutical Sciences (PhD)
Universidade de Coimbra, Portugal
2010/10/01 - 2013/02/08 New Sustainable Processes Catalyzed by Acids with Pharmaceutical Interest
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/07 Derivatização de Esteróides Assistida por Micro-ondas
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/06 Semi-síntese de Novos Derivados Flavonóides Bioactivos. Estudo de Reacções de Acilação e Desacilação Regiosselectivas Recorrendo a Lipases como Catalisadores.
Co-supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2013/02/06 Caracterização Estrutural de Novos Triterpenóides Pentacíclicos
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/25 Marcadores de Neoplasia e de Infecção por Vírus JC em Cólon Human.
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/16 Estudo Sistemático da Formação de Estrutura em Processos de Microencapsulação por Evaporação de Solvente
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/10/11 Monitorização da Cinética de Formação de Microcápsulas usando uma Técnica de Dispersão de Luz
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/27 Tratamento de Efluentes Líquidos da Indústria Farmacêutica pelo Processo de Fenton
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/26 Modificações Estruturais de Compostos Polifenólicos Glicosidados e Modulação das suas Actividades Antioxidantes
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/24 Manufacturing Process and Quality Control of Solid Dosage Forms Optimization for the Pharmaceutical Industry by Near Infrared Spectroscopy and Chemometric Analysis
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/20 Preparação de novos Derivados Flavonóides com Potencial Actividade Biológica
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2010/10/01 - 2012/09/17 Derivados Xantónicos Prenilados: Obtenção de Análogos Estruturais da a-Mangostina e Avaliação da Actividade Antitumoral
Supervisor
Industrial Pharmaceutical Chemistry (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2005/10/01 - 2011/05/04 Síntese e avaliação da citotoxicidade de novos compostos triterpénicos pentacíclicos do tipo lupano
Supervisor
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra, Portugal
2005/01/01 - 2010/03/29 Novos processos com reagentes e catalisadores de bismuto usando esteróides como substratos
Supervisor
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra, Portugal
2003/11/01 - 2008/06/05 Novos esteróides inibidores da biossíntese de androgéneos
Supervisor
Pharmaceutical Sciences: sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra, Portugal
2002/10/01 - 2007/03/26 Novos processos de oxidação ambientalmente aceitáveis usando esteróides como substratos
Supervisor
Pharmaceutical Sciences- sub-area Pharmaceutical Chemistry (PhD)
Universidade de Coimbra, Portugal
2002/10/01 - 2004/12/02 Síntese de Novos 6-Azidoesteróides Potenciais Inibidores da Aromatase
Supervisor
Chemistry (Master)
Universidade de Coimbra Departamento de Química, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2021/02/24 - Current Member of the evaluation committees Swiss National Science Foundation, Switzerland.
2020/12/15 - Current -Reviewer of the European Research Council, ERC Advanced Grants. European Research Council
2020/12 - Current -Member of evaluation committees from A3ES.
Member
2018/05/25 - Current Member of the evaluation committees Research Foundation-Flanders, Belgian,
2017 - Current Member of the Evaluation Committee, Transnational Projects, Portugal-Brazil.
Member
Universidade de Coimbra, Portugal Fundação para a Ciência e a Tecnologia
2017 - Current Member of the Evaluation Committee, Transnational Projects, Portugal-Hungary.
Member
Universidade de Coimbra, Portugal
2017 - Current Member of the Evaluation Committee, Transnational Projects, Portugal-France.
Member
Universidade de Coimbra, Portugal
2014/01/01 - Current Member of the Evaluation Committee National Science Centre, Poland
Evaluator
2014 - Current -Member of evaluation committees from Fundação para a Ciência e a Tecnologia (FCT), the Portuguese Research Council
Member
Fundação para a Ciência e a Tecnologia
2016 - 2020 Board of Directors & Selection Comittee Member, MedChemTrain PhD program Fundação para a Ciência e a Tecnologia

Journal scientific committee

Journal title (ISSN) Publisher
2020/02/01 - Current Molecules-Section Medicinal Chemistry MDPI
2019 - Current Frontiers in Oncology- Guest Associate Editor (2234-943X) Frontiers Media SA
2015 - Current Current Green Chemistry (2213-3461) Bentham Science
Distinctions

Award

2009 Award IAPMEI atribuído no Concurso de Ideias “Arrisca Coimbra 09”
Universidade de Coimbra, Portugal
2009 Award DNA-Saúde, Concurso de Ideias “Arrisca Coimbra 09
Universidade de Coimbra, Portugal
2009 1º Award CEBT do Curso de Empreendedorismo de Base Tecnológica (4ºEdição), Junho de 2009, atribuído ao projecto LEAD.
Universidade de Coimbra, Portugal
1987 Award "Sociedade Farmacêutica Lusitana" best student, Faculdades de Farmácia do Ramo Farmácia Industrial, Licenciatura 81/87.
Ordem dos Farmaceuticos, Portugal

Other distinction

2013 O projecto de doutoramento envolvendo a estudante Vânia Maria Antunes Moreira (SFRH/BD/12508/2003.) continuado com o pos-doc (SFRH/BPD/45037/2008) foi seleccionado para difusão através da rede ATOMIUM CULTURE, Bringing Europe to the Forefront.
1999 Post-doc grant FUNDAÇÃO CALOUSTE GULBENKIAN na Universidade de Sussex (U.K.) durante o ano lectivo 1999/2000.
1989 MSc grant from INIC , 1989/90, processo nº28881
INIC, Portugal
1984 Lic. Grant from FUNDAÇÃO CALOUSTE GULBENKIAN, processo nº 179/84 (suspensão da Bolsa à data da entrada em exercício do contrato de monitor).