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Joana Almeida is a young early career researcher whose main fields of interest are Medicinal Chemistry and Oncobiology. She obtained her Bachelor's in Biology at the Faculty of Sciences of the University of Porto in 2017, and in 2019 she obtained her Master¿s Degree in Pharmaceutical Chemistry at the Faculty of Pharmacy of the University of Porto. Throughout her academic courses, she developed skills in Cellular and Molecular Biology through works involving several screening and Molecular Biology techniques, as well as in Organic and Medicinal Chemistry through synthesis and structure elucidation of organic compounds. Currently, she is a PhD student at LAQV/REQUIMTE/FFUP aiming at the discovery of new therapies targeting the p53 family pathways in neuroblastoma under the supervision of Prof. Lucília Saraiva, Prof. Emília Sousa and Prof. Honorina Cidade (FFUP). Published 7 articles in international peer-reviewed journals and 9 conference papers. Has 5 oral presentations, 9 posters and 2 event organisations. Has received 2 awards and/or honors. Works in the area(s) of Natural Sciences with emphasis on Health Sciences, Pharmacology and Medicinal/Organic Chemistry.
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Identification

Personal identification

Full name
Joana Filipa Duarte Almeida
Date of birth
1995/09/15
Gender
Female

Citation names

  • Almeida, Joana
  • Joana Filipa D. Almeida
  • Joana Almeida
  • Almeida, J.
  • Almeida J.

Author identifiers

Ciência ID
1112-8E07-16EB
ORCID iD
0000-0003-2325-5439
Scopus Author Id
57208816698

Email addresses

  • joanaalmeida15@gmail.com (Professional)
  • up201303752@edu.ff.up.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Clinical Medicine - Oncology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Beginner (A1)
French Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2020/12/03 - 2025/01/01
Ongoing
 PhD in Pharmaceutical Sciences (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/09 - 2019/07
Concluded
 Pharmaceutical Chemistry (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Chalcone derivatives: promising starting points for the discovery of new diarylpentanoids with p53-MDM2/X inhibitory activity" (THESIS/DISSERTATION)
 16
2013/09 - 2017/06
Concluded
 Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Apoptotic and necrotic effects of 3’,4’-dihydroxyflavonol on the MG-63 cell line" (THESIS/DISSERTATION)
 13
Projects

Grant

Designation Funders
2021/01/01 - 2025/01/01 Improving Neuroblastoma Therapy with p53 Family-targeting Agents
2020.05026.BD
PhD Student Fellow
Universidade do Porto Faculdade de Farmácia, Portugal

REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference paper
  1. J. Moreira; J. Almeida; M. Pinto; L. Saraiva; H. Cidade. "Abstract P053 - A new diarylpentanoid as potential disruptor of p53-MDM2/MDMX interactions". Paper presented in XXVII Encontro Nacional da Sociedade Portuguesa de Química, 2021.
    Published
  2. Joana Moreira; Joana Almeida; Madalena Pinto; Lucília Saraiva; Honorina Cidade. "Abstract P085 - Disruption of p53-MDM2/MDMX interactions mediated by a new promising diarylpentanoid". Paper presented in 56th International Conference on Medicinal Chemistry, 2021.
    Published
  3. Mariana Silva; Joana Almeida; Diana Resende; Madalena Pinto; Lucília Saraiva; Emília Sousa. "Seeking for an improved activator of TAp73 in neuroblastoma therapy". Paper presented in 14º Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2021.
    Published
  4. Moreira, Joana; Brandão, Pedro; Almeida, Joana; Nazareth, Nair; Sampaio-Dias, Ivo E.; Vasconcelos, Vitor; Martins, Rosário; et al. "Norhierridin B, a new hierridin B-based hydroquinone with improved antiproliferative activity". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
    10.3390/ECMC2020-07491
  5. Barcherini, Valentina; Almeida, Joana; Lopes, Elizabeth Abre; Wang, Mi; Magalhães e Silva, Diogo; Mori, Mattia; Wang, Shaomeng; Saraiva, Lucília; Santos, Maria M.M.. "Optimizing the oxazoloisoindolinone family: Identification and biological evaluation of a potent and selective indole-based p53 activator in human colorectal cancer". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
    10.3390/ECMC2020-07503
  6. Joana Almeida*; Joana Moreira* (Equally contributing authors); Madalena Pinto; Lucília Saraiva; Honorina Cidade. "Abstract 16717: Modelling p53-MDM2/X interactions with C-5 curcuminoids". Paper presented in 13º Encontro de Investigação Jovem da Universidade do Porto (IJUP) 2020, Porto, 2020.
    Published
  7. Raimundo, Liliana; Saraiva, Lucília; Espadinha, Margarida; Soares, Joana; Loureiro, Joana; Calheiros, Juliana; Nazareth, Nair; et al. "Improving colon cancer therapy with a new promising small-molecule activator of the p53-pathway through disruption of p53-MDM2/MDMX interactions". Paper presented in 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06306
  8. Nazareth, Nair; Almeida, Joana; Lemos, Agostinho; Moreira, Joana; Pinto, Madalena; Chlapek, Petr; Veselsk, Renata. "Design and molecular docking studies of new potential PKC-d activators based on royleanone scaffold". 2019.
    10.3390/ecmc2019-06297
  9. J. M. P. Ferreira de Oliveira; J. F. D. Almeida; M. Martins; E. Fernandes; C. Santos. "Abstract KL-8: Regulation of Cyclin and Cyclin-Dependent Kinase Expression by 3', 4'-Dihydroxyflavonol in Human In Vitro Models". Paper presented in 11th Joint Meeting on Medicinal Chemistry 2019, Praga, 2019.
    Published
Conference poster
  1. Mota, Inês; Almeida, Joana; Barros, Matilde; Resende, Diana; Almeida, Inês; Sousa, Emilia; Saraiva, Lucília. "LEM3: A Promising Anticancer Agent for Neuroblastoma Therapy by Targeting Tap73". Paper presented in 15º Encontro de Investigação Jovem da Universidade do Porto, 2022.
  2. Joana Almeida*; Joana Moreira* (Equally contributing authors); Joana Soares; Madalena Pinto; Lucília Saraiva. "Abstract 15113: Identification of new MDM2 p53 interaction inhibitors using yeast cell based models". Paper presented in 12º Encontro de Investigação Jovem da Universidade do Porto (IJUP) 2019, 2019.
Journal article
  1. Joana Almeida; Inês Mota; Jan Skoda; Emília Sousa; Honorina Cidade; Lucília Saraiva. "Deciphering the Role of p53 and TAp73 in Neuroblastoma: From Pathogenesis to Treatment". Cancers (2022): https://doi.org/10.3390/cancers14246212.
    10.3390/cancers14246212
  2. Moreira, Joana; Almeida, Joana; Loureiro, Joana B.; Ramos, Helena; Palmeira, Andreia; Pinto, Madalena M.; Saraiva, Lucília; Cidade, Honorina. "A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation". ChemMedChem 16 19 (2021): 2969-2981. http://dx.doi.org/10.1002/cmdc.202100337.
    Published • 10.1002/cmdc.202100337
  3. José Miguel P. Ferreira de Oliveira; Joana Filipa D. Almeida; Maria Martins; Carina Proença; Helena Oliveira; Eduarda Fernandes; Conceição Santos. "3',4'-Dihydroxyflavonol Modulates the Cell Cycle in Cancer Cells: Implication as a Potential Combination Drug in Osteosarcoma". Pharmaceuticals 14 7 (2021): 640-640. https://doi.org/10.3390/ph14070640.
    10.3390/ph14070640
  4. Joana Moreira; Joana Almeida; Lucília Saraiva; Honorina Cidade; Madalena Pinto. "Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness". Molecules 26 12 (2021): 3737-3737. https://doi.org/10.3390/molecules26123737.
    10.3390/molecules26123737
  5. Barcherini, Valentina; Almeida, Joana; Lopes, Elizabeth A.; Wang, Mi; Magalhães e Silva, Diogo; Mori, Mattia; Wang, Shaomeng; Saraiva, Lucília; Santos, Maria M. M.. "Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer". ChemMedChem (2020): http://dx.doi.org/10.1002/cmdc.202000522.
    10.1002/cmdc.202000522
  6. Brandão, Pedro; Moreira, Joana; Almeida, Joana; Nazareth, Nair; Sampaio-Dias, Ivo E.; Vasconcelos, Vitor; Martins, Rosário; et al. "Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity". Molecules 25 7 (2020): 1578. http://dx.doi.org/10.3390/molecules25071578.
    Open access • Published • 10.3390/molecules25071578
  7. Ramos, Helena; Calheiros, Juliana; Almeida, Joana; Barcherini, Valentina; Santos, Sónia; Carvalho, Alexandra T. P.; Santos, Maria M.M.; Saraiva, Lucília. "SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner". International Journal of Molecular Sciences 21 2 (2020): 596. http://dx.doi.org/10.3390/ijms21020596.
    Open access • Published • 10.3390/ijms21020596
  8. Matias, Diogo; Nicolai, Marisa; Fernandes, Ana Sofia; Saraiva, Nuno; Almeida, Joana; Saraiva, Lucília; Faustino, Célia; et al. "Comparison Study of Different Extracts of Plectranthus madagascariensis, P. neochilus and the Rare P. porcatus (Lamiaceae): Chemical Characterization, Antioxidant, Antimicrobial and Cytotoxic Activities". Biomolecules 9 5 (2019): 179. http://dx.doi.org/10.3390/biom9050179.
    Open access • Published • 10.3390/biom9050179
Thesis / Dissertation
  1. Joana Almeida. "Chalcone derivatives: promising starting points for the discovery of new diarylpentanoids with p53-MDM2/X inhibitory activity". Master, Universidade do Porto Faculdade de Farmácia, 2019.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/02/19 Searching for improved LEM2-derivatives for neuroblastoma therapy SPF meeting 2021
Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2020/02/07 Regulation Of Glucose Metabolism, Angiogenesis And Migration Of Colon Cancer by The p53 Activator SLMP53-1 SPF Meeting 2020
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2020/02/07 SLMP53-2: A Mutant p53 Reactivator With Promising Activity In Skin Cancer Prevention SPF Meeting 2020
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2020/02/07 New Diarylpentanoids: Synthesis and Evaluation of p53-MDM2/X Inhibitory Activity SPF Meeting 2020
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/11/26 Diarylpentanoids as potential inhibitors of the p53-MDM2/X interactions Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto
Universidade do Porto Faculdade de Farmácia (Porto, Portugal)
2019/11/20 POSTER - C5-Curcuminoids: a promising starting point for discovery of new dual inhibitors of p53-MDM2/X XXV Encontro Galego-Portugués de Química
Colegio Oficial de Químicos de Galicia (Santiago de Compostela, Spain)
2019/11/15 POSTER - Potential inhibition of the p53-MDM2/X interactions by C-5 curcuminoids Day of the Microbiology Laboratory
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2019/11/15 POSTER - Production of recombinant mutant p53 R280K in Escherichia coli: structural elucidation and direct modulation by the anticancer drug SLMP53-1 Day of the Microbiology Laboratory
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2019/09/24 POSTER - Diarylpentanoids with Potential Dual Inhibitory Activity in the Interaction p53-MDM2/MDMX 1º Encontro Nacional de Jovens Investigadores em Oncologia
Núcleo Regional do Norte da Liga Portuguesa Contra o Cancro (Porto, Portugal)
2019/03/18 POSTER - Bischalcones targeting MDM2-p53 interaction: synthesis and biological activity Escola de Inverno de Farmácia 2019 - 4ª Edição
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2018/07/17 POSTER - Anti-proliferative effects of 3’,4’-dihydroxyflavonol in the U2OS osteosarcoma cell line Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChemSicily2018)
Società Chimica Italiana (Palermo, Italy)
2017/11/15 POSTER - Apoptotic and necrotic effects of 3’,4’-dihydroxyflavonol on the MG-63 cell line XXIII Encontro Galego – Portugués de Química
Colegio Oficial de Químicos de Galicia (Ferrol, Spain)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/04/30 - 2020/10 6º Encontro de Biotecnologia Microbiana e Farmacêutica (POSTPONED) (2020/04/30 - 2020/10)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal
2019/07/08 - 2019/07/12 Model organisms in human disease: the right organism for a specific question (2019/07/08 - 2019/07/12)
Other (Member of the Organising Committee)
 Universidade do Porto Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/06/07 - 2021/06/07 Investigação por Questionário - Vantagens e Limitações
Conference
Universidade do Porto Faculdade de Farmácia, Portugal
2021/06/02 - 2021/06/02 Introdução às Revisões Sistemáticas e Meta-Análise
Conference
Universidade do Porto Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/10/27 - 2021/10/27 Web of Science e Scopus: pesquisa em bases de dados de citações Universidade do Porto Faculdade de Farmácia, Portugal
2021/10/13 - 2021/10/13 PubMed: pesquisa por palavra e assunto, limitação de resultados, acesso ao texto integral dos artigos Universidade do Porto Faculdade de Farmácia, Portugal
2021/09/06 - 2021/09/17 Advanced course in Laboratory Animal Science - FELASA accredited course Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/01/29 - 2021/01/29 Introdução ao EndNote X9: da criação de uma biblioteca à escrita de um documento Universidade do Porto Faculdade de Farmácia, Portugal
2021/01/27 - 2021/01/27 Avaliação de revistas científicas: o fator de impacto e outros índices (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Award

2020 Best Master Thesis in Medicinal Chemistry 2019
Sociedade Portuguesa de Química, Portugal

Other distinction

2019 Honorable Mention for the oral presentation entitled "Diarylpentanoids as potential inhibitors of the p53-MDM2/X interactions"
Universidade do Porto Faculdade de Farmácia, Portugal