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I an a researcher at RISE-Health@FMUP. I study chronic pelvic pain mechanism, aiming to find new treatment opportunities and biomarkers (follow-up and diagnostic). I am also interested in understanding how human behavior influences chronic pelvic pain, in order to prevent it or, at least, prevent flare episodes. Together with a team of Urologists, we have repurposed the use of a medication that is effective in a subpopulation of chronic pelvic patients. At the translational level, I have developed new animal models to work in Interstitial Cystitis/Bladder Pain Syndrome. I was PI of a AUGS project, work package co-leader of IMI PainCare project (ended 03/2023), and an was responsible investigator of a FCT project. I also investigate the mechanisms that lead to lower urinary tract symptoms. I developed translation work both in the detrusor underactivity (DU) and bladder overactivity (OAB) fields. I have worked with animal models that mimic the pathology associated with DU (an animal model of BOO and an ageing model). Recently, I have identified an animal model for the study of OAB (stress model in males). I was a researcher in the Incomb European project and of Astellas Urethra project in close collaboration with urologists. I have published seminal papers in this field (some with more than 100 citations) and I have ongoing collaboration with national and international scientists. Have DGAV authorization to perform scientific experiments working with animals and I am obtaining the certificate of Clinical Investigator.
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Identification

Personal identification

Full name
Ana Cristina Estrela de Oliveira Charrua Cordeiro

Citation names

  • Charrua, Ana

Author identifiers

Ciência ID
1116-DC10-D5BE
ORCID iD
0000-0002-7717-7790
AuthenticusID
R-000-JPW
Google Scholar ID
4NUZB3gAAAAJ&hl
Researcher Id
I-8229-2019
Scopus Author Id
6506736634

Email addresses

  • anacharr@gmail.com (Professional)
  • anacharr@med.up.pt (Professional)
  • ana.charrua@ibmc.up.pt (Professional)

Telephones

Fax
  • 225513655 (Professional)
Telephone
  • 225513654 (Professional)

Addresses

  • Rua Dr. Plácido Costa, 91, 5º, 4200, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2010
Concluded
 Doutoramento em Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"TRPV1 role in visceral inflammation" (THESIS/DISSERTATION)
 Aprovado
2001
Concluded
 Mestrado em Toxicologia (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
1997
Concluded
 Microbiologia (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"-" (THESIS/DISSERTATION)
 13 valores
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
2018/01/01 - 2018/12/31 Contracted Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2010 - 2023 Team member of Translational Neurourology group Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/07/01 - 2020/07/01 Professor instructor on Master in Neurobiology program Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2009/05/11 - 2020/05/01 Professor instructor in Neuroscience Doctoral Program (PDN) Universidade do Porto Faculdade de Medicina, Portugal
2001/11/01 - 2017/12/01 research fellow Universidade do Porto Faculdade de Medicina, Portugal
2011/08/01 - 2017/07/01 Postdoc - FCT - SFRH / BPD / 68716 / 2010 Universidade do Porto Faculdade de Medicina, Portugal
2006/03/01 - 2012/09/29 Invited Assistant professor Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2010/08/01 - 2011/07/01 Postdoc - projecto EU project INComb FP7 HEALTH project no 223234 Universidade do Porto Faculdade de Medicina, Portugal
1999/10/01 - 2001/06/01 Researcher - MSci in Toxicology Universidade de Aveiro, Portugal
1998/05/01 - 1998/08/01 Organization of an International Cientific Meeting Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
1998/01/01 - 1998/05/01 Research technician Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1997/12/01 - 1997/12/31 Research technician Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
Projects

Grant

Designation Funders
2011/08 - 2017/07 ROLE OF SYMPATHETIC FIBRES ON CHRONIC BLADDER PAIN
Provided by PTCRIS: SFRH/BPD/68716/2010
 Fundação para a Ciência e a Tecnologia
2014/01 - 2014/12 BIomarcadores e mecanismOs na CIStite inTErsticial.
Provided by PTCRIS: EXPL/NEU-SCC/0288/2013
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2018/04 - 2022/03 Improving the care of patients suffering from acute or chronic pain
777500
PFD Research Foundation and ICA IC/PBS Research Grant 2015
Co-Principal Investigator (Co-PI)
European Commission
Ongoing
2018 - 2018 Urethra
AGM-2016-002400
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Allergan AG
Concluded
2015 - 2015 Sympathetic nervous system dysfunction is a trigger to BPS/IC symptoms development
EXPL_NEU-SCC_0288_2013
Principal investigator
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 PFD Research Foundation and ICA IC/PBS Research Grant 2015
Concluded
2014/01/01 - 2014/12/31 Biomarkers and mechanisms of Interstitial Cystitis
EXPL/NEU-SCC/0288/2013
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 InComb - combating incontinence
INComb FP7 HEALTH project no 223234
Research Fellow
Universidade do Porto Faculdade de Medicina, Portugal
 European Union
Concluded
2007 - 2008 BOTOX mode of action. Study bladder structures target by Botox.
N/A
Research Fellow
Universidade do Porto Faculdade de Medicina, Portugal
 Allergan AG
Concluded
2004 - 2006 Mecanismos sensitivos da bexiga hiperativa
POCTI/SAU-NSE/55983/2004
Research Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
2001 - 2003 Papel dos neurónios sensitivos que expressam os receptores vanilóides em patologias articulares e urinárias.
POCTI/32466/NSE/2000
Scientific Initiation Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
1998 - 1998 Caracterização genética de 6q16.3-q21 no carcinoma gástrico
Praxis/PSAU/C/SAU/115/96
Technical development
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1997 - 1997 Improving the quality and safety of whole fresh fish - Effects of modified atmospheres on the growth and survival of foodborne pathogens.
AIR2 CCT94 1496
Technical development
Outputs

Publications

Book
  1. Charrua, A.; Avelino, A.; Cruz, F.. Modulation of urinary bladder innervation: TRPV1 and botulinum toxin A. 2011.
    10.1007/978-3-642-16499-6_17
  2. Faculdade de Ciências da Nutrição e Alimentação. TRP channels in the urinary bladder and prostate: implications for therapy.. Portugal. 2011.
  3. Charrua, Ana; Cruz, F.. TRP channels in the urinary bladder and prostate: implications for therapy.. 2011.
Book chapter
  1. Charrua, A.; Cruz, F.. "TRP channels in the urinary bladder and prostate: Implications for therapy". 243-258. 2011.
Conference abstract
  1. Nunez Badinez, P; Nagel, J; De Leo, B; Saunders, P; Simitsidellis, I; Krings, D; Tzschentke, T; et al. "Value of Animal Models for Translational Research in Pelvic Pain: A Systematic Literature Review on Preclinical Models of Endometriosis and IC/BPS.". 2020.
  2. Matos, R; Cruz, F; Charrua, A. "EARLY LIFE STRESSFUL EVENTS INDUCE CHRONIC BLADDER PAIN IN ADULTHOOD INVOLVEMENT OF TRPV1.". 2019.
  3. Coelho, A; Morgado, A; Oliveira, R; Cruz, CD; Charrua, A; Cruz, F. "AGING ASSOCIATED UNDERACTIVE BLADDER INVOLVES A DECREASE IN URETHRAL SEROTONIN RELEASED BY 5HT-EXPRESSING CELLS. AN EXPERIMENTAL STUDY IN RAT.". 2018.
  4. Dias, B; Charrua, A; Cruz, F. "CHRONIC STRESS INCREASES PLASMATIC AND URINARY LEVELS OF NGF LEADING TO INCREASED BLADDER PAIN AND BLADDER HYPERACTIVITY. EXPERIMENTAL STUDY IN THE RAT.". 2018.
  5. Charrua, A; Matos, R; Serrao, P; Cruz, F. "BLADDER PAIN INDUCED IN RATS BY CHRONIC STRESS IS MEDIATED BY PROLONGED STIMULATION OF ALPHA 1A ADRENOCEPTORS". 2016.
  6. Charrua, A; Matos, R; Marczylo, T; Nagy, I; Cruz, F. "FATTY ACID AMIDE HYDROLASE INHIBITOR IMPROVES FUNCTION OF INFLAMED BLADDERS BY SIMULTANEOUS MODULATION OF ANANDAMIDE AND PALMITOLYLETHANOLAMIDE LEVELS.". 2015.
  7. Charrua, A; Cruz, C; Boudes, M; De Ridder, D; Cruz, F. "TRPV1 AND TRPV4 ANTAGONISTS HAVE A SYNERGISTIC EFFECT DURING CYSTITIS". 2012.
  8. Charrua, A; Pinto, R; Frias, B; Cruz, CD; Cruz, F. "TRPV1 EXPRESSION IN THE BLADDER IS ESSENTIAL FOR NGF-INDUCED DETRUSOR OVERACTIVITY". 2009.
  9. Frias, B; Charrua, A; Pinto, R; Allen, S; Dawbarn, D; Cruz, F; Cruz, CD. "INTRATHECAL BLOCKADE OF TRK RECEPTOR AND NEUROTROPHINS SEQUESTRATION REDUCES PAIN AND URINARY FREQUENCY IN AN ANIMAL MODEL OF CHRONIC BLADDER INFLAMMATION". 2009.
  10. Silva, A; Cruz, CD; Charrua, A; Pinto, R; Avelino, A; Silva, C; Dinis, P; Cruz, F. "GRC 6211, a new oral TRPV1 antagonist, decreases neurogenic detrusor overactivity in a rat model of spinal cord transection". 2008.
  11. Cruz, F; Charrua, A; Reguenga, C; Paule, C; Nagy, I; Avelino, A. "TRPV1 expression in human urothelial cells". 2008.
  12. Charrua, A; Reguenga, C; Paule, C; Nagy, I; Cruz, F; Avelino, A. "Down-regulation of the TRPV1b splice variant in dorsal root ganglia innervating the inflamed urinary bladder of the rat". 2008.
  13. Charrua, A; Avelino, A; Nagy, I; Cruz, F. "Functional properties of TRPV1 expressed in human urothelial cells". 2006.
  14. Cruz, F; Cruz, C; Charrua, A; Avelino, A; McMahon, SB. "Spinal cord phosphorylation of extracellular signal-regulated kinases (ERKs) is induced by sensory input conveyed in capsaicin-resistant bladder afferents and contributes to pain and bladder reflex overactivity in a chronic cystitis rat model". 2004.
Conference paper
  1. Faculdade de Ciências da Nutrição e Alimentação. "BDNF sequestration improves bladder function in spinal cord injured animals". 2012.
    10.1016/S1569-9056(12)60365-0
  2. Frias, B.; Charrua, Ana; Santos, J.; Allen, S.; Cruz, F.; Cruz C.D.. "BDNF sequestration improves bladder function in spinal cord injured animals". 2012.
    10.1016/S1569-9056(12)60365-0
  3. Faculdade de Ciências da Nutrição e Alimentação. "Estará o síndrome doloroso vesical/cistite intersticial associado uma disfunção simpática?". 2011.
  4. Charrua, Ana; Pinto, R.; Taylor, AM.; Barros, S.; Silva A. Ribeiro da; Cruz, F.. "Estará o síndrome doloroso vesical/cistite intersticial associado uma disfunção simpática?". 2011.
Conference poster
  1. Beatriz Resende; Vilas-Boas, Inês; Alexandre Gonçalves; Inês N Alves; Liliana Leite; Juliana Morais; Sandra Moraña-Fernández; et al. "Brain Gains: Maternal Ketogenic Diet Effects on Offspring Behavior". Paper presented in YES - Young European Scientist - Meeting, 2024.
  2. Vilas-Boas, Inês; Falcão-Pires, Inês; Charrua, Ana; Ferreira, Susana Maria de Sousa da Silva. "Acting From the Heart: Behavior and Cognitive Function of Rats with Heart Failure with Preserved Ejection Fraction and Empagliflozin Effects". Paper presented in FENS Forum Vienna, Austria, 2024.
  3. Alves IN; Gonçalves, Alexandre; Araújo M; Leite L; Moraña-Fernández S; Morais, Juliana; Rodrigues, Alexandre; et al. "Long-term ketogenic diet increases heart hypertrophy and modulates glycemic control and physical endurance in a sex-dependent manner in aged healthy rats". Paper presented in CBFH Biennial Meeting 2023 | Biennial Meeting of the ESC Working Group on Myocardial Function & Cellular Biology of the Heart, 2023.
Journal article
  1. Guldal Inal; Dick Janssen; Naside Mangir; Francisco Cruz; Ana Charrua. "Current clinical status of IC/BPS and what the future holds in basic & translational science". Continence (2024): https://doi.org/10.1016/j.cont.2024.101338.
    10.1016/j.cont.2024.101338
  2. Rita Matos; Liliana Santos-Leite; Francisco Cruz; Ana Charrua. "Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors". Neurourology and Urodynamics (2024): https://doi.org/10.1002/nau.25376.
    10.1002/nau.25376
  3. Coxon, L.; Lugt, C.; Horne, A.W.; Evans, E.; Abreu-Mendes, P.; Arendt-Nielsen, L.; Aziz, Q.; et al. "Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain (TRiPP))". BJOG: An International Journal of Obstetrics and Gynaecology (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85198838597&partnerID=MN8TOARS.
    10.1111/1471-0528.17915
  4. Faria-Costa, G.; Oliveira, J.; Vilas-Boas, I.; Campelo, I.; Silva, E.A.; Brás-Silva, C.; Silva, S.M.; Antunes-Lopes, T.; Charrua, A.. "The Ketone Bridge Between the Heart and the Bladder: How Fast Should We Go?". International Neurourology Journal 28 suppl 1 (2024): 2-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85186690864&partnerID=MN8TOARS.
    10.5213/inj.2346250.125
  5. Oliveira, J.; Faria-Costa, G.; Charrua, A.; Vale, L.; Silva, J.; Antunes-Lopes, T.. "Urinary Biomarkers of Detrusor Underactivity". Current Bladder Dysfunction Reports 19 1 (2024): 83-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-85183364297&partnerID=MN8TOARS.
    10.1007/s11884-024-00737-7
  6. Vale, L.; Cruz, F.; Charrua, A.. "Detrusor Overactivity After Partial Bladder Outlet Obstruction Is Associated With High Urinary Adenosine Triphosphate Levels in Female Wistar Rats". International Neurourology Journal 28 suppl 1 (2024): 34-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-85186712128&partnerID=MN8TOARS.
    10.5213/inj.2346196.098
  7. Michel Wyndaele; Ana Charrua; François Hervé; Patrik Aronsson; Luke Grundy; Vik Khullar; Alan Wein; et al. "Beyond the urothelium: Interplay between autonomic nervous system and bladder inflammation in urinary tract infection, bladder pain syndrome with interstitial cystitis and neurogenic lower urinary tract dysfunction in spinal cord injury—ICI-RS 2023". Neurourology and Urodynamics (2023): https://doi.org/10.1002/nau.25310.
    10.1002/nau.25310
  8. Lydia Coxon; Jan Vollert; Danielle Perro; Claire E. Lunde; Joana Ferreira-Gomes; Ana Charrua; Pedro Abreu-Mendes; et al. "Comprehensive quantitative sensory testing shows altered sensory function in women with chronic pelvic pain: results from the Translational Research in Pelvic Pain (TRiPP) Study". Pain Publish Ah (2023): https://doi.org/10.1097%2Fj.pain.0000000000002955.
    10.1097/j.pain.0000000000002955
  9. Ana Catarina Neto; Mariana Santos-Pereira; Pedro Abreu-Mendes; Delminda Neves; Henrique Almeida; Francisco Cruz; Ana Charrua. "The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models". Biomedicines (2023): https://doi.org/10.3390/biomedicines11030696.
    10.3390/biomedicines11030696
  10. Abreu-Mendes P; Araújo-Silva B; Charrua A; Cruz F; Pinto R. "Silodosin Improves Pain and Urinary Frequency in Bladder Pain Syndrome/Interstitial Cystitis Patients.". Journal of clinical medicine (2022): http://europepmc.org/abstract/med/36233527.
    10.3390/jcm11195659
  11. Faria-Costa G; Charrua A; Martins-Silva C; Leite-Moreira A; Antunes-Lopes T. "Myogenic Underactive Bladder and Heart Failure Resemblance: A Novel Role for SGLT2 Inhibition?". European urology focus (2022): http://europepmc.org/abstract/med/35599200.
    10.1016/j.euf.2022.04.016
  12. Pedro Abreu-Mendes; Aurora Costa; Ana Charrua; Rui Almeida Pinto; Francisco Cruz. "The Role of Urinary VEGF in Observational Studies of BPS/IC Patients: A Systematic Review". Diagnostics 12 5 (2022): 1037-1037. https://doi.org/10.3390/diagnostics12051037.
    10.3390/diagnostics12051037
  13. Vale L; Charrua A; Cavaleiro H; Ribeiro-Oliveira R; Avelino A; Antunes-Lopes T; Albino-Teixeira A; Cruz F. "DU Is Induced by Low Levels of Urinary ATP in a Rat Model of Partial Bladder Outlet Obstruction: The Incidence of Both Events Decreases after Deobstruction.". Advances in urology (2022): http://europepmc.org/abstract/med/35265122.
    10.1155/2022/6292457
  14. Ana Charrua; Pedro Mendes; Célia Cruz. "Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis". Current Bladder Dysfunction Reports (2021): https://doi.org/10.1007/s11884-020-00626-9.
    10.1007/s11884-020-00626-9
  15. Nunez-Badinez, P; De Leo, B; Laux-Biehlmann, A; Hoffmann, A; Zollner, TM; Saunders, PT; Simitsidellis, I; et al. "Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome". Pain (2021):
    10.1097/j.pain.0000000000002248
  16. Santos-Pereira M; Charrua A. "Understanding underactive bladder: a review of the contemporary literature.". Porto biomedical journal (2020): http://europepmc.org/abstract/med/32734011.
    10.1097/j.pbj.0000000000000070
  17. Ana Charrua; Rita Matos; Raquel Oliveira; Tim Marczylo; Istvan Nagy; Francisco Cruz. "Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats". Naunyn-Schmiedeberg's Archives of Pharmacology (2020): https://doi.org/10.1007/s00210-019-01729-9.
    10.1007/s00210-019-01729-9
  18. Bruno Dias; Paula Serrão; Francisco Cruz; Ana Charrua. "Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-50576-4.
    10.1038/s41598-019-50576-4
  19. Ana Coelho; Ana Charrua; Raquel Oliveira; Helena Cavaleiro; Célia D. Cruz; Francisco Cruz. "Underactive bladder in aging rats is associated with a reduced number of serotonin-expressing cells in the urethra and is improved by serotonin application to the urethra". LUTS: Lower Urinary Tract Symptoms (2019): https://doi.org/10.1111/luts.12273.
    10.1111/luts.12273
  20. Cordeiro, Ana. "TRPV1 Antagonists as Novel Anti-Diabetic Agents: Regulation of Oral Glucose Tolerance and Insulin Secretion Through Reduction of Low-Grade Inflammation?". Medical sciences (Basel, Switzerland) (2019): http://europepmc.org/articles/PMC6722836.
    10.3390/medsci7080082
  21. Antunes-Lopes T; Vasconcelos A; Costa D; Charrua A; Neves J; Silva J; Cruz F; Silva C. "The impact of chronic pelvic ischemia on LUTS and urinary levels of neuro-inflammatory, inflammatory and oxidative stress markers in elderly men: a case-control study.". Urology (2018): http://europepmc.org/abstract/med/30219559.
    10.1016/j.urology.2018.09.004
  22. Vale, L; Charrua, A; Avelino, A; Lopes, T; Birder, LA; Cruz, F. "PD19-04 BLADDER SENSORY MECHANISM EARLY IMPAIRMENT INDUCES DETRUSOR UNDERACTIVITY (DU) FOLLOWING BLADDER OUTLET OBSTRUCTION (BOO)". Journal of Urology (2018):
    10.1016/j.juro.2018.02.994
  23. R. Pinto; D. Costa; A. Morgado; P. Pereira; A. Charrua; J. Silva; F. Cruz. "Intra-Trigonal Onabotulinum Toxin A improves bladder symptoms and quality of life in Bladder Pain Syndrome /Interstitial Cystitis patients – a pilot, single centre, randomized, double-blind, placebo-controlled trial". The Journal of Urology (2017): https://doi.org/10.1016%2Fj.juro.2017.10.018.
    10.1016/j.juro.2017.10.018
  24. Rita Matos; Paula Serrão; Larissa Rodriguez; Lori Ann Birder; Francisco Cruz; Ana Charrua. "The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation". Naunyn-Schmiedeberg's Archives of Pharmacology (2017): https://doi.org/10.1007%2Fs00210-017-1384-1.
    10.1007/s00210-017-1384-1
  25. Rita Matos; Paula Serrão; Larissa Rodriguez; Lori Birder; Francisco Cruz; Ana Charrua. "PD01-04 STRESS INDUCED VISCERAL PAIN IS MEDIATED BY ALPHA 1A ADRENOCEPTORS". The Journal of Urology 197 4 (2017): e47-e47. https://doi.org/10.1016%2Fj.juro.2017.02.184.
    10.1016/j.juro.2017.02.184
  26. Rita Matos; Francisco Cruz; Ana Charrua. "MP29-03 CHILDHOOD STRESSFUL EVENTS INDUCE CHRONIC BLADDER PAIN IN ADULTHOOD THROUGH A TRPV1 DEPENDENT MECHANISM". The Journal of Urology 197 4 (2017): e380-e381. https://doi.org/10.1016%2Fj.juro.2017.02.915.
    10.1016/j.juro.2017.02.915
  27. R. Matos; P. Serrão; L. Rodrigues; L.A. Birder; F. Cruz; A. Charrua. "The water avoidance stress induces bladder pain due to a prolonged adrenergic (alpha1A) stimulation of the bladder". European Urology Supplements 16 3 (2017): e350-e351. https://doi.org/10.1016%2Fs1569-9056%2817%2930267-1.
    10.1016/s1569-9056(17)30267-1
  28. Charrua, Ana; Matos, Rita; Marczylo, Tim; Nagy, Istvan; Cruz, Francisco. "FAAH Inhibitor Improves Function of Inflamed Bladders by Modulation of Anandamide and Palmitoylethanolamide". (2017): https://doi.org/10.24915/aup.34.3-4.14.
    https://doi.org/10.24915/aup.34.3-4.14
  29. Matos R; Cordeiro JM; Coelho A; Ferreira S; Silva C; Igawa Y; Cruz F; Charrua A. "Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release.". (2016): http://europepmc.org/abstract/med/27370818.
    10.1111/apha.12744
  30. Silva M; Martins D; Charrua A; Piscitelli F; Tavares I; Morgado C; Di Marzo V. "Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.". (2016): http://europepmc.org/abstract/med/26965218.
    10.1016/j.neuropharm.2016.03.007
  31. Oliveira R; Coelho A; Charrua A; Avelino A; Cruz F; Oliveira, R.; Coelho, A.; et al. "Expression of cleaved SNAP-25 after bladder wall injection of onabotulinumtoxinA or abobotulinumtoxinA: A comparative study in the mice.". Neurourology and Urodynamics 36 1 (2015): 86-90. http://europepmc.org/abstract/med/26472491.
    10.1002/nau.22900
  32. Charrua A; Pinto R; Birder LA; Cruz F. "Sympathetic nervous system and chronic bladder pain: a new tune for an old song.". (2015): http://europepmc.org/abstract/med/26816852.
    10.3978/j.issn.2223-4683.2015.09.06
  33. D. Matos; Y. Igawa; F. Cruz; A. Charrua. "1086 Adrenergic over-activity induces bladder pain and hyperactivity by increasing TRPV1 excitability". European Urology Supplements 14 2 (2015): e1086-e1086a. http://dx.doi.org/10.1016/s1569-9056(15)61074-0.
    10.1016/s1569-9056(15)61074-0
  34. Charrua, A.; Pinto, R.; Taylor, A.; Canelas, A.; Ribeiro-da-Silva, A.; Cruz, C.D.; Birder, L.A.; Cruz, F.. "Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study". Neurourology and Urodynamics 34 5 (2015): 489-496. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930869301&partnerID=MN8TOARS.
    10.1002/nau.22542
  35. Charrua, A.; Cruz, C.D.; Jansen, D.; Rozenberg, B.; Heesakkers, J.; Cruz, F.. "Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis". BJU International 115 3 (2015): 452-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922965308&partnerID=MN8TOARS.
    10.1111/bju.12861
  36. A. Charrua; I. Nagy; F. Cruz. "372 FAAH inhibition reverses bladder hyperactivity and pain induced by cystitis through a CB1 dependent mechanism". European Urology Supplements 13 1 (2014): e372-e372. http://dx.doi.org/10.1016/s1569-9056(14)60367-5.
    10.1016/s1569-9056(14)60367-5
  37. Frias, B.; Allen, S.; Dawbarn, D.; Charrua, A.; Cruz, F.; Cruz, C.D.. "Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation". Neuroscience 234 (2013): 88-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873488462&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2012.12.044
  38. Avelino, A.; Charrua, Ana; Frias, B.; Cruz, C.; Boudes, M.; de Ridder, D.; Cruz, F.. "Transient receptor potential channels in bladder function". (2013): https://repositorio-aberto.up.pt/handle/10216/98543.
  39. A. Charrua; M. Boudes; Ridder D. De; C.D. Cruz; F. Cruz. "366 TRPV1 and TRPV4 expression in bladder neurons during normal condition and during cystitis". European Urology Supplements 11 1 (2012): e366-e366. http://dx.doi.org/10.1016/s1569-9056(12)60363-7.
    10.1016/s1569-9056(12)60363-7
  40. B. Frias; A. Charrua; J. Santos; S. Allen; F. Cruz; C. Cruz. "368 BDNF sequestration improves bladder function in spinal cord injured animals". European Urology Supplements 11 1 (2012): e368-e368. http://dx.doi.org/10.1016/s1569-9056(12)60365-0.
    10.1016/s1569-9056(12)60365-0
  41. A. Charrua; C.D. Cruz; F. Cruz. "365 TRPV1 and TRPV4 antagonists have synergistic effect for treating bladder overactivity in rats". European Urology Supplements 11 1 (2012): e365-e365. http://dx.doi.org/10.1016/s1569-9056(12)60362-5.
    10.1016/s1569-9056(12)60362-5
  42. Santos-Silva, A.; Charrua, A.; Cruz, C.D.; Gharat, L.; Avelino, A.; Cruz, F.; Faculdade de Ciências da Nutrição e Alimentação. "Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist". Autonomic Neuroscience: Basic and Clinical 166 1-2 (2012): 35-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855942949&partnerID=MN8TOARS.
    10.1016/j.autneu.2011.09.005
  43. Faculdade de Ciências da Nutrição e Alimentação; Frias, B.; Charrua, A.; Avelino, A.; Michel, M.C.; Cruz, F.; Cruz, C.D.; et al. "Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input". OBJECTIVES To explore the role of transient receptor potential vanilloid 1 (TRPV1) in the excitatory effects of chronic administration of nerve growth factor (NGF) on bladder-generated sensory input and reflex activity. To explore new therapeutic targets for bladder dysfunction. MATERIALS AND METHODS Wild-type (WT) and TRPV1 knockout (KO) mice received daily intraperitoneal injections of NGF (1 mu 110 8 Pt B (2012): E422-E428. https://repositorio-aberto.up.pt/handle/10216/101026.
    10.1111/j.1464-410X.2012.11187.x
  44. Faculdade de Ciências da Nutrição e Alimentação; Gorgal, T.; Charrua, A.; Silva, J.F.; Avelino, A.; Dinis, P.; Cruz, F.. "Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type A injection". BMC Urology 12 (2012): 1471-2490.
    10.1186/1471-2490-12-1
  45. Santos-Silva, A.; Charrua, Ana; Cruz C.D.; Gharat, L.; Avelino, A.; Cruz, F.. "Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist". (2012): https://hdl.handle.net/10216/96992.
    10.1016/j.autneu.2011.09.005
  46. Frias, B.; Charrua, Ana; Avelino, A.; Michel, M.C.; Cruz, F.; Cruz, C.D.. "Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input". (2012): https://hdl.handle.net/10216/101026.
    10.1111/j.1464-410X.2012.11187.x
  47. Gorgal, T.; Charrua, Ana; Silva, J.F.; Avelino, A.; Dinis, P.; Cruz, F.. "Expression of apoptosis-regulating genes in the rat prostate following botulinum toxin type A injection". (2012): https://hdl.handle.net/10216/65151.
    10.1186/1471-2490-12-1
  48. Ana Charrua; Rui Pinto; Anne Taylor; Sérgio Barros; Alfredo Ribeiro-da-Silva; Célia D Cruz; António Avelino; Francisco Cruz. "813 INCREASED SYMPATHETIC ACTIVITY ENHANCES BLADDER HYPERACTIVITY AND TRIGGERS BLADDER PAIN". The Journal of Urology 185 4 (2011): e327-e327. http://dx.doi.org/10.1016/j.juro.2011.02.631.
    10.1016/j.juro.2011.02.631
  49. A. Charrua; R. Pinto; A.M. Taylor; S. Barros; A. Ribeiro-Da-Silva; C.D. Cruz; A. Avelino; F. Cruz. "974 AUTONOMIC SYMPATHETIC NERVOUS SYSTEM ACTIVITY IS ENHANCED DURING CHRONIC INFLAMMATION AND CONTRIBUTES TO BLADDER HYPERACTIVITY AND PAIN". European Urology Supplements 10 2 (2011): 304-304. http://dx.doi.org/10.1016/s1569-9056(11)60956-1.
    10.1016/s1569-9056(11)60956-1
  50. F. Cruz; A. Charrua; B. Frias; A. Avelino; C.D. Cruz. "118 NGF-INDUCE DETRUSOR OVERACTIVITY IS TRPV1 DEPENDENT". European Urology Supplements 9 2 (2010): 69-69. http://dx.doi.org/10.1016/s1569-9056(10)60123-6.
    10.1016/s1569-9056(10)60123-6
  51. Charrua, A.; Avelino, A.; Silva, A.; Cruz, F.. "TRPV1 in GU disorders". Open Drug Discovery Journal 2 SPEC. ISS. (2010): 50-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863952961&partnerID=MN8TOARS.
    10.2174/1877381801002030050
  52. Charrua, A.; Reguenga, C.; Cordeiro, J.M.; Correiade-Sá, P.; Paule, C.; Nagy, I.; Cruz, F.; Avelino, A.. "Functional Transient Receptor Potential Vanilloid 1 is Expressed in Human Urothelial Cells". Journal of Urology 182 6 (2009): 2944-2950. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849109253&partnerID=MN8TOARS.
    10.1016/j.juro.2009.08.022
  53. Charrua, A.; Cruz, C.D.; Narayanan, S.; Gharat, L.; Gullapalli, S.; Cruz, F.; Avelino, A.. "GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models". Journal of Urology 181 1 (2009): 379-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-57149095621&partnerID=MN8TOARS.
    10.1016/j.juro.2008.08.121
  54. Francisco Cruz; Ana Charrua; Celia Cruz; Shridhar Narayanan; Laxmikant Gharat; Srinivas Gullapalli; Antonio Avelino. "THE ORAL TRPV1 ANTAGONIST GRC 6211 REDUCES BLADDER OVERACTIVITY AND NOXIOUS BLADDER INPUT IN CYSTITIS". The Journal of Urology 179 4 (2008): 539-539. http://dx.doi.org/10.1016/s0022-5347(08)61584-0.
    10.1016/s0022-5347(08)61584-0
  55. F. Cruz; A. Charrua; C. Cruz; L. Gharat; S. Gullapalli; S. Narayanan; A. Avelino. "GRC 6211, A NEW ORAL TRPV1 ANTAGONIST, DECREASES THE FREQUENCY OF BLADDER REFLEX CONTRACTIONS AND NOXIOUS INPUT IN RATS WITH ACUTE OR CHRONIC CYSTITIS". European Urology Supplements 7 3 (2008): 181-181. http://dx.doi.org/10.1016/s1569-9056(08)60440-6.
    10.1016/s1569-9056(08)60440-6
  56. Charrua, A.; Reguenga, C.; Paule, C.C.; Nagy, I.; Cruz, F.; Avelino, A.; Ana Charrua; et al. "Cystitis is associated with TRPVIb-downregulation in rat dorsal root ganglia". NeuroReport 19 15 (2008): 1469-1472. http://www.scopus.com/inward/record.url?eid=2-s2.0-53549103863&partnerID=MN8TOARS.
    10.1097/WNR.0b013e32830f1e73
  57. Cruz, C.D.; Charrua, A.; Vieira, E.; Valente, J.; Avelino, A.; Cruz, F.. "Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals". Experimental Neurology 214 2 (2008): 301-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-56349119753&partnerID=MN8TOARS.
    10.1016/j.expneurol.2008.08.016
  58. Charrua, A; Reguenga, C; Paule, CC; Nagye, I; Cruz, F; Avelino, A. "Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia". NEUROREPORT (2008):
    10.1097/wnr.0b013e32830fle73
  59. F. Cruz; A. Charrua; C. Paule; I. Nagy; A. Avelino. "61 TRPV1 IN HUMAN UROTHELIAL CELLS IS FUNCTIONAL AND ITS EXPRESSION IS UP-REGULATED BY INFLAMMATORY MEDIATORS". European Urology Supplements 6 2 (2007): 38-38. http://dx.doi.org/10.1016/s1569-9056(07)60060-8.
    10.1016/s1569-9056(07)60060-8
  60. Baiou, D.; Santha, P.; Avelino, A.; Charrua, A.; Bacskai, T.; Matesz, K.; Cruz, F.; Nagy, I.. "Erratum: Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice (Journal of Comparative Neurology (2007) 503, (334-347))". Journal of Comparative Neurology 504 5 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-35348838403&partnerID=MN8TOARS.
    10.1002/cne.21456
  61. Baiou, D.; Santha, P.; Avelino, A.; Charrua, A.; Bacskai, T.; Matesz, K.; Cruz, F.; Nagy, I.. "Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice". Journal of Comparative Neurology 503 2 (2007): 334-347. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447650771&partnerID=MN8TOARS.
    10.1002/cne.21389
  62. Charrua, A.; Cruz, C.D.; Cruz, F.; Avelino, A.. "Transient Receptor Potential Vanilloid Subfamily 1 is Essential for the Generation of Noxious Bladder Input and Bladder Overactivity in Cystitis". Journal of Urology 177 4 (2007): 1537-1541. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947262029&partnerID=MN8TOARS.
    10.1016/j.juro.2006.11.046
  63. P. Dinis; A. Charrua; A. Avelino; R. Cruz. "270High frequency of bladder reflex contractions observed in acute and chronic bladder inflammation is dependent upon TRPV1 (vanilloid receptor) expression". European Urology Supplements 4 3 (2005): 70-70. http://dx.doi.org/10.1016/s1569-9056(05)80278-7.
    10.1016/s1569-9056(05)80278-7
  64. Dinis, P.; Charrua, A.; Avelino, A.; Nagy, I.; Quintas, J.; Ribau, U.; Cruz, F.. "The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate". European Urology 48 1 (2005): 162-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-20644439327&partnerID=MN8TOARS.
    10.1016/j.eururo.2005.01.009
  65. P. Dinis; A. Charrua; A. Avelino; I. Nagy; J. Quintas; M. Reis; F. Cruz. "420 Distribution of the sensory fibres immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate". European Urology Supplements 3 2 (2004): 107-107. http://dx.doi.org/10.1016/s1569-9056(04)90417-4.
    10.1016/s1569-9056(04)90417-4
  66. Dinis, P.; Charrua, A.; Avelino, A.; Yaqoob, M.; Bevan, S.; Nagy, I.; Cruz, F.. "Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis". Journal of Neuroscience 24 50 (2004): 11253-11263. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644240899&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2657-04.2004
  67. Dinis, P.; Charrua, A.; Avelino, A.; Cruz, F.. "Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders". BJU International 94 1 (2004): 153-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242772894&partnerID=MN8TOARS.
    10.1111/j.1464-4096.2004.04855.x
  68. Dinis, P; Charrua, A; Avelino, A; Cruz, F. "Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders". BJU INTERNATIONAL (2004):
    10.1111/j.1464-410x.2004.04855.x
  69. Sathianathan, V.; Avelino, A.; Charrua, A.; Santha, P.; Matesz, K.; Cruz, F.; Nagy, I.. "Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons". European Journal of Neuroscience 18 9 (2003): 2477-2486. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344011522&partnerID=MN8TOARS.
    10.1046/j.1460-9568.2003.03004.x

Other

Other output
  1. FAAH Inhibitor Improves Function of Inflamed Bladders by Modulation of Anandamide and Palmitoylethanolamide. Introduction: We aim to study the effect of fatty acid amide hydrolase (FAAH) blockade on bladder hyperactivity and on fatty acid amides levels during cystitis. Material and Methods: Cystitis was induced in female Wistar rats using 5 mg/mL lipopolysaccharide (LPS). Control group were intravesical instilled with saline. LPS and control groups received intravenously (caudal vein) during cystometry:. 2017. Charrua, Ana; Matos, Rita; Marczylo, Tim; Nagy, Istvan; Cruz, Francisco. http://www.actaurologicaportuguesa.com/index.php/aup/article/view/14.
    https://doi.org/10.24915/aup.34.3-4.14
  2. TRP Channels as Therapeutic Targets. 2015. M. Allen McAlexander; Ganesan Baranidharan; Ralf Baron; Arun K. Bhaskar; Mahendra Bishnoi; Jill-Desiree Brederson; Dorothy Cimino Brown; et al. http://dx.doi.org/10.1016/b978-0-12-420024-1.09996-3.
    10.1016/b978-0-12-420024-1.09996-3
  3. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders. 2015. Ana Charrua; Francisco Cruz; Charrua, A.; Cruz, F.. http://dx.doi.org/10.1016/b978-0-12-420024-1.00007-2.
    10.1016/b978-0-12-420024-1.00007-2
  4. Transient receptor potential channels in bladder function. The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons. The urothelium and some interstitial cells also express several TRP channels. In this review,. 2013. Faculdade de Ciências da Nutrição e Alimentação; Avelino, A.; Charrua, A.; Frias, B.; Cruz, C.; Boudes, M.; de Ridder, D.; Cruz, F.. http://hdl.handle.net/10216/98543.
    10.1111/apha.12021
  5. TRP Channels in the Genitourinary Tract. 2012. Ana Charrua; Francisco Cruz. http://dx.doi.org/10.1007/978-1-62703-077-9_19.
    10.1007/978-1-62703-077-9_19
  6. Cystitis is Associated With TRPV1b-Downregulation in Rat Dorsa I Root Ganglia Comment. 2009. Charrua, A; Reguenga, C; Paule, CC; Nagy, I; Cruz, F; Avelino, A.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/04 Adrenergic modulation and chronic pelvic pain: From the clinic to the lab and back to the clinic. Weekly online TL2 meeting
RISE-FMUP (Porto, Portugal)
2019/10/10 Neurotrophins and stress in bladder pain 26th Meeting of EAU Section of Urological Research ESUR19
ESUR (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01 - Current Mecanismos sensitivos na origem do Detrusor Hipoativo
Co-supervisor
 Medicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2019 - Current Sindrome doloroso vesical
Co-supervisor
 Medicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2014 Characterization of an animal model of Bladder painful syndrome/interstitial cystitis
Supervisor
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/09/28 - 2023/09/28 Current clinical status of BPS/IC and what the future holds in basic & translational science (2023/09/28 - 2023/09/28)
Workshop (Co-organisor)
 International Continence Society, United Kingdom
2022/07/04 - 2022/07/15 Continuing training unit - Behavioural test in rodents (2022/07/04 - 2022/07/15)
Other (Co-organisor)
 Universidade do Porto Faculdade de Medicina, Portugal
2019/10/24 - 2019/10/25 Statistical course applied to basic research - Curso de Estatística Aplicada à Investigação Básica (2019/10/24 - 2019/10/25)
Workshop (President of the Organising Committee)
 Universidade do Porto Faculdade de Medicina, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/06/08 - 2023/06/10 ICI-RS - Consultation on urinary bladder research - workgroup of leading scientist in field of urology
Meeting
 10th meeting of the ICI-RS
International Consultation on Incontinence - Research Society, United Kingdom

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018/07/04 O impacto da diminuição do fluxo sanguíneo pélvico induzido pela aterosclerose na função vesical de homens idosos
(Thesis) Main arguer
 Alice Porto Guerra Vasconcelos (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2015/05/22 Tratamento do Síndrome Doloroso Vesical/Cistite intersticial - implicações clínicas fisio-patológicas
Thesis Member
 Rui Miguel Correia de Almeida Pinto (PhD)
Universidade do Porto Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2023/04 - Current International Consultation on Incontinence – Research Society Full member
2015/01 - Current International Continence Society Member
2010/01 - Current Sociedade Portuguesa de Neurociências Membro efetivo
2010/01/01 - 2021/12/31 International Association for the Study of Pain Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2009/05/11 - Current Primary neuronal cell culture PDN (Curso de doutoramento (conclusão de unidades curriculares)) Universidade do Porto Faculdade de Medicina, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2017 - Current Neuropharmacology (0028-3908) Elsevier
2016 - Current International Journal of Urology (1442-2042) Wiley (Blackwell Publishing)
2016 - Current Medicine (0025-7974) Wolters Kluwer Health
2014 - Current British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2014 - Current BJU International (1464-410X) Wiley (Blackwell Publishing)
2014 - Current Neurourology and Urodynamics (1520-6777) Wiley (John Wiley & Sons)
Distinctions

Award

2018 First prize - Grunenthal prize for the study of pain
2016 3rd Prize for best meeting poster
SINUG, Spain
2015 3rd Prize for best meeting poster
Associação Portuguesa de Urologia, Portugal
2009 Best poster
Associação Portuguesa de Urologia, Portugal
2008 Honorable Mention - Grunenthal Prize for the Study of Pain
Fundação Grünenthal, Portugal
2008 Best poster session
European Association of Urology, Netherlands
2008 Best Poster
European Association of Urology, Netherlands

Other distinction

2017 Outstanding contribution in reviewing - Neuropharmacology
2016 3º Prize for best meeting poster
2015 Top 10 Reviewer
Neurourology and Urodynamics, United States
2015 3º Prize for best meeting poster
2015 Best session poster
European Association of Urology, Netherlands
2015 Paper of the week
2014 Best session poster
European Association of Urology, Netherlands
2009 Best poster - Portuguese Meeting of Urology
2008 Best poster - XXII EAU Meeting
European Association of Urology, Netherlands
2008 Best poster session - XXII EUA Congress
European Association of Urology, Netherlands
2006 Honorable Mention - Grunenthal prize for the study of pain