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Mónica holds a licentiate degree in Biomedical Laboratory Sciences, which gave her technical skills for numerous biochemical and microbiological approaches of detecting and quantifying biological samples. During her MSc in Biomedical Research, she specialized in immunity and infection gaining new technical skills for immune-related technics of cell sorting (magnetic) and flow cytometry (from bench to analyses). While obtaining her Dr. rer. nat. degree (PhD equivalent), Mónica studied the molecular elements of the circadian related with immunological pathways at Humboldt-Universität zu Berlin Lebenswissenschaftliche Fakultät. For that, she developed proficiency in analyzing biological rhythms and performing genetic manipulation, as well as training in analyzing high-throughput gene expression data with posterior gene set enrichment analysis. She published 11 papers, organized one event and was involved in 4 main projects. Currently she is a Assistant Researcher at Multidisciplinary Institute of Aging, MIA Portugal.
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Identification

Personal identification

Full name
Mónica Teresa Parente Abreu

Citation names

  • Abreu, Mónica
  • Monica Teresa Abreu

Author identifiers

Ciência ID
111A-E3EE-F12D
ORCID iD
0000-0003-0626-7999
Google Scholar ID
2p9OT5gAAAAJ&view_op

Email addresses

  • monica.abreu@uc.pt (Professional)

Addresses

  • Faculdade de Medicina - Polo I, 3º piso , Rua Larga, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2021/05/31
Concluded
 Machine Learning A-Z: Hands-On Python and R in Data Science (Curso médio)
Major in Data science
Udemy Inc, United States
2021/02/09
Concluded
 R Programming: Advanced Analytics In R For Data Science (Curso médio)
Major in Data science
Udemy Inc, United States
2020/09/24
Concluded
 Introduction to Data Management Plans (Curso médio)
BioData.pt, Portugal
2020/05/08
Concluded
 R Programming A-Z™: R For Data Science With Real Exercises! (Curso médio)
Major in Data science
Udemy Inc, United States
2015/03/05 - 2019/04/12
Concluded
 Biologie (Doktor (PhD))
Major in Molekularbiologie
Humboldt-Universität zu Berlin Lebenswissenschaftliche Fakultät, Germany
 Magna Cum Laude
2017/10 - 2017/10
Concluded
 Scientific Writing (Curso médio)
Humboldt Graduate School, Germany
2016/02 - 2016/02
Concluded
 Translational Bioinformatics (Curso médio)
Guy's and Saint Thomas' NHS Foundation Trust, United Kingdom

King's College London, United Kingdom
2015/06 - 2015/06
Concluded
 Analysis of transcriptome data (Curso médio)
Berlin-Brandenburger Centrum für Regenerative Therapien, Germany
2009/09/14 - 2012/04/20
Concluded
 Mestrado em Investigação Biomédica (Mestrado)
Major in Infecção e Imunidade
Universidade de Coimbra Faculdade de Medicina, Portugal
 17
2007 - 2008/09/18
Concluded
 Análises Clínicas e de Saúde Pública (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2004 - 2007/07/20
Concluded
 Análises Clínicas e de Saúde Pública (Bacharelato)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
Affiliation

Science

Category
Host institution 		Employer
2022/01/07 - 2023/10/03 Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra - Multidisciplinary Institute of Aging, MIA Portugal, Portugal
2019/09/02 - 2021/12/29 Postdoc (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
2014/11/17 - 2017/12/31 Research Assistant (Research) Charité Universitätsmedizin Berlin, Germany
2010/07/01 - 2014/10/31 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2010/07/01 - 2014/10/31 Research Trainee (Research) CNC.IBILI, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020/01/01 - 2020/07/31 Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2023/04/01 - Current Mitochondria-lysosome communication as a driver of age-related pathology
2022.09311.PTDC
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
2023/04/01 - Current Different intracellular AMPK pools modulate mitochondria-ER contact sites
2022.04407.PTDC
Post-doc
2019/09/02 - 2022/09/02 Do lado direito: desvendando os mecanismos de reversibilidade e progressão da hipertensão pulmonar na insuficiência cardíaca
POCI -01-0145-FEDER-032414
Post-doc Fellow
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2014/11/17 - 2017/12/31 CiRSPLICE - Zirkadiane Regulierung des Spleißens in der Tumorprogression: Ein systembiologischer Ansatz
FKZ031A316
Other
Charité Universitätsmedizin Berlin, Germany

Humboldt Universität zu Berlin Institute for Theoretical Biology, Germany
Bundesministerium für Bildung und Forschung Dienststelle Berlin

Other

Designation Funders
2013/06/01 - 2013/07/31 LRRK2 role on auto-antibody production by human B cells
not applicable
Research Technician Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 The Michael J Fox Foundation for Parkinson's Research
Concluded
2012/09/01 - 2012/10/31 LRRK2 Role on Auto-Antibody Production by human B Cells
not applicable
Research Technician Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 The Michael J Fox Foundation for Parkinson's Research
Outputs

Publications

Book chapter
  1. El-Athman, Rukeia; Mazuch, Jeannine; Fuhr, Luise; Abreu, Mónica; Genov, Nikolai; Relógio, Angela. "Methods for the visualization of circadian rhythms: From molecules to organisms". In Fluorescence Imaging and Biological Quantification, 231-257. CRC Press, 2017.
    10.1201/9781315121017-13
Conference abstract
  1. Abreu, Mónica. "TNF and the clockwork: a reciprocal interplay.". Paper presented in EMBO|EMBL Symposia Biological Oscillators: Design, Mechanism, Function, Heidelberg, 2018.
    Published
  2. Abreu, Mónica; Relógio, Angela. "Circadian regulation of the immune system: a role in tumourigenesis.". Paper presented in 40th FEBS Congress, The Biochemical Basis of Life, Berlin, 2015.
    Published
  3. Ângelo, AF; Abreu, Mónica; Gonçalves, Milene; Souto-Carneiro, Margarida. "Phenotypic characterization of the peripheral blood IgD-CD27- B cell subset in children, adults and senior adults.". Paper presented in XXXVIII Annual meeting of the Portuguese Society of Immunology: From immune disorders to immunotherapies, Porto, 2012.
  4. Abreu, Mónica; Gonçalves, Milene; Carvalheiro, Helena; Souto-Carneiro, Margarida; Holmdahl, R; Rodrigues-Santos, Paulo. "Ncf1 mutant B10.Q mice with defective Reactive Oxygen Species (ROS) production show impaired peripheral NK cell differentiation". Paper presented in NK and NKT Cell Biology: Specificity and Redundancy of Innate Responses, Colorado, 2011.
Journal article
  1. Abreu, Mónica Teresa; Baptista, Rui; Girão, Henrique. "Immune cell subsets as a marker of development of heart failure: The application of bioinformatics tools". Revista Portuguesa de Cardiologia (English Edition) 40 11 (2021): 849-851. http://dx.doi.org/10.1016/j.repce.2021.10.021.
    Open access • Published • 10.1016/j.repce.2021.10.021
  2. Abreu, M; Ferreira, C; Baptista, R. "Multi-species transcriptomic data analysis reveal three candidate genes, responsible for the transition from compensated left ventricle hypertrophy to heart failure". European Heart Journal 42 Supplement (2021): http://dx.doi.org/10.1093/eurheartj/ehab724.3292.
    Open access • 10.1093/eurheartj/ehab724.3292
  3. Ferreira, C; Abreu, M; Castro, G; Goncalves, L; Baptista, R; Girao, H. "Metabolic reprogramming in pulmonary arterial hypertension: is it a cancer-like disease?". European Heart Journal 42 Supplement (2021): http://dx.doi.org/10.1093/eurheartj/ehab724.3414.
    10.1093/eurheartj/ehab724.3414
  4. Abreu, Mónica. "Micro-RNA Analysis in Pulmonary Arterial Hypertension". JACC: Basic to Translational Science 5 11 (2020): 1149-1162. http://dx.doi.org/10.1016/j.jacbts.2020.07.008.
    10.1016/j.jacbts.2020.07.008
  5. Abreu, Mónica. "Proinflammatory profile of autoimmune CD8 + T cells relies on increased LDHA activity and aerobic glycolysis". Arthritis & Rheumatology (2020): http://dx.doi.org/10.1002/art.41420.
    10.1002/art.41420
  6. Nikolai Genov; Alireza Basti; Mónica Abreu; Rosario Astaburuaga; Angela Relógio. "A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-47343-w.
    10.1038/s41598-019-47343-w
  7. Fuhr, Luise; Abreu, Mónica; Carbone, Annalucia; El-Athman, Rukeia; Bianchi, Fabrizio; Laukkanen, Mikko O.; Mazzoccoli, Gianluigi; Relógio, Angela. "The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes". Cancers (2019): http://dx.doi.org/10.3390/cancers11070988.
    10.3390/cancers11070988
  8. Nikolai Genov; Alireza Basti; Mónica Abreu; Angela Relógio. "Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines". International Journal of Molecular Sciences 20 5 (2019): 1182-1182. https://doi.org/10.3390/ijms20051182.
    10.3390/ijms20051182
  9. Mónica Abreu; Alireza Basti; Nikolai Genov; Gianluigi Mazzoccoli; Angela Relógio. "The reciprocal interplay between TNFa and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29847-z.
    10.1038/s41598-018-29847-z
  10. El-Athman R; Genov NN; Mazuch J; Zhang K; Yu Y; Fuhr L; Abreu M; et al. "The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity.". PLoS biology (2017): http://europepmc.org/abstract/med/29216180.
    10.1371/journal.pbio.2002940
  11. Lehmann R; Childs L; Thomas P; Abreu M; Fuhr L; Herzel H; Leser U; Relógio A. "Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach.". PLoS ONE (2015): http://europepmc.org/abstract/med/25945798.
    10.1371/journal.pone.0126283
  12. Fuhr L; Abreu M; Pett P; Relógio A. "Circadian systems biology: When time matters.". Computational and structural biotechnology journal (2015): http://europepmc.org/abstract/med/26288701.
    10.1016/j.csbj.2015.07.001
  13. Abreu MT; Carvalheiro H; Rodrigues-Sousa T; Domingos A; Segorbe-Luis A; Rodrigues-Santos P; Souto-Carneiro MM; et al. "Alterations in the peripheral blood B cell subpopulations of multidrug-resistant tuberculosis patients.". Clinical and experimental medicine (2014): http://europepmc.org/abstract/med/24068613.
    Published • 10.1007/s10238-013-0258-1
  14. Bustin SA; Benes V; Garson J; Hellemans J; Huggett J; Kubista M; Mueller R; et al. "The need for transparency and good practices in the qPCR literature.". Nature methods (2013): http://europepmc.org/abstract/med/24173381.
    10.1038/nmeth.2697
  15. Silva, Diogo; Abreu, Mónica; Couceiro, Patrícia; F. Teixeira, Margarida; Ladeira, Inês; Viveiros, Filipa; Duarte, Raquel; Sá, Helena; Rodrigues-Santos, Paulo. "Increase of Reactive Oxygen Species in Natural Killer cells from Pulmonary Tuberculosis patients". Frontiers in Immunology (2013): http://dx.doi.org/10.3389/conf.fimmu.2013.02.00533.
    10.3389/conf.fimmu.2013.02.00533
  16. Abreu, Mónica; Carvalheiro, Helena; Duarte, Cátia; Pereira-da-Silva, José; Souto-Carneiro, Margarida; Rodrigues-Santos, Paulo. "Expression of CD62L, CD27 and CD11b define a marked cytotoxic effector role for NK cells in rheumatoid arthritis". Annals of the Rheumatic Diseases (2011): http://dx.doi.org/10.1136/ard.2010.148999.5.
    10.1136/ard.2010.148999.5
Thesis / Dissertation
  1. Abreu, Mónica. "TNF, a Briding Element Connecting the Circadian Clock and Molecular Elements of the Immune Systems in Hodgkin's Lymphoma Cells". PhD, Humboldt-Universität zu Berlin Lebenswissenschaftliche Fakultät, 2019.
  2. Abreu, Mónica Teresa Parente. "Role of natural killer cells in the progression of Mycobacterium tuberculosis infection to pulmonary disease". Master, 2011. http://hdl.handle.net/10316/25059.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/08/27 Multi-species transcriptomic data analysis reveal three candidate genes, responsible for the transition from compensated left ventricle hypertrophy to heart failure ESC Congress 2021- The Digital Experience
2015/07/05 Circadian regulation of the immune system: a role in tumourigenesis 40th FEBS Congress, The Biochemical Basis of Life (2015)
(Berlim, Germany)
2012/04/22 Role of Natural Killer cells in Mycobacterium tuberculosis infection to pulmonary disease XII Jornadas de Análises Clínicas e Saúde Pública em Coimbra
(Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2007/10/01 - 2008/03/15 Membro da comissão organizadora das VIII Jornadas de Análises Clínicas e Saúde Pública. Elaboração de programa científico. Planeamento da logística necessária à realização do evento. (2008/02/29 - 2008/03/01)
Congress (Member of the Organising Committee)
 Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal