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My name is Margarida Pacheco, I studied Biochemistry (BSc and MSc) at the University of Minho, Braga, Portugal. During my master thesis I worked on the development and characterization of various protein variants, through genetic engineering, with the objective to improve the stability of a cold-adapted enzyme in acidic pHs. During that year I worked in the areas of microbiology, genetic engineering, bioinformatics and techniques of protein production and characterization. On July 2018 I was awarded with a research fellowship at i3Bs Research Group and my research focus started to change and became closer to biomaterials. My first works at i3Bs were dedicated to the functionalization of polymers (both degradable and non-degradable) for urological applications. In 2019 I engaged the PhD and since October 2019 I have been working on my PhD project which focuses on a comprehensive characterization of biodegradable metal's corrosion and encrustation propensity in urinary tract environment, as well as their biocompatibility and possible antibacterial activity, envisioning the utilization of biodegradable metals, specifically Mg alloys, for biodegradable metallic ureteral stent development.
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Identification

Personal identification

Full name
Margarida Pacheco

Citation names

  • Pacheco, Margarida

Author identifiers

Ciência ID
131D-75DD-387A

Email addresses

  • amrpacheco297@gmail.com (Professional)
  • margarida.pacheco@i3bs.uminho.pt (Professional)

Telephones

Mobile phone
  • 916368029 (Personal)
Telephone
  • 253510900 (Professional)

Addresses

  • AvePark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal (Professional)
  • Bouça de Montão nº 12, 4880-165, Mondim de Basto, Mondim de Basto, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Clinical Medicine - Urology and Nephrology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2019/10/01 - 2023/10/01
Ongoing
 Tissue Engineering, Regenerative Medicine and Stem Cells (TERM(SC) (Doutoramento)
Biomaterials Biodegradables and Biomimetics, Portugal
2018/01/08 - 2018/03/25
Concluded
 Engenharia de Tecidos e Medicina Regenerativa (Outros)
Universidade do Minho, Portugal
 18
2015/09/01 - 2017/12/19
Concluded
 Bioquímica Aplicada (Mestrado)
Major in Biomedicina
Universidade do Minho, Portugal
"Deciphering the role of exposed surface residues in protein stability" (THESIS/DISSERTATION)
 17,4
2012/09/01 - 2015/07/31
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica
Universidade do Minho, Portugal
"Bioatividades de própolis" (THESIS/DISSERTATION)
 15,4
Affiliation

Science

Category
Host institution 		Employer
2019/10/01 - 2023/10/01 Researcher (Research) Biomaterials Biodegradables and Biomimetics, Portugal
Universidade do Minho, Portugal
2018/07/02 - 2019/09/30 Researcher (Research) Biomaterials Biodegradables and Biomimetics, Portugal
Universidade do Minho, Portugal
Projects

Grant

Designation Funders
2019/10/01 - 2023/10/01 Ureteral stenting using biodegradable metals
SFRH/BD/145285/2019
PhD Student Fellow
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2019/01/01 - 2019/09/30 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
info:eu-repo/grantAgreement/FCT/5876/147272/PT
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/02 - 2019/03/31 ELASTISLET
646075
Research Fellow
Horizon 2020
Ongoing

Other

Designation Funders
2021/09/05 - 2023/11/30 Additive Manufacturing for the Life Sciences
2019-00029
Invited Scientist Fellow
Uppsala Universitet, Sweden
Ongoing
2019/10/14 - 2023/10/13 Green Chemical Engineering Network towards upscaling sustainable processes
CA18224
Other
Universidade Nova de Lisboa, Portugal
Ongoing
2020/07/01 - 2023/09/30 A metal-based biodegradable ureteral stent
047112
PhD Student Fellow
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Pacheco, Margarida; Domingues, Beatriz; Lima, Estêvão; Reis, Rui L.; Barros, Alexandre. "Hydrogels as stents". In Hydrogels for Tissue Engineering and Regenerative Medicine, 467-482. Elsevier, 2024.
    Published • 10.1016/b978-0-12-823948-3.00023-3
  2. Pacheco, Margarida; Silva, Joana M.; Aroso, Ivo; Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "Biomaterials for Ureteral Stents: Advances and Future Perspectives". In Urinary Stents, 197-208. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-04484-7_17
Conference abstract
  1. Pacheco, Margarida; Ivo Aroso; Joana Silva (5919-006C-53B8); Sviatlana Lamaka; Mikhail Zheludkevich; Jan Bohlen; Maria Nienaber; et al. "Insights on the degradation profile of magnesium alloys in a simulated urinary tract environment". Paper presented in 12th Symposium on Biodegradable Metals, Alicante, 2021.
    Submitted
Conference poster
  1. Pacheco, Margarida; Lamaka, Sviatlana V.; Zheludkevich, Mikhail; Bohlen, Jan; Nienaber, Maria; Letzig, Dietmar; Hassila, Carl-Johan; et al. "Suitability of additive manufacturing for biodegradable urinary devices: an in vitro study". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, 2023.
  2. Pacheco, Margarida; Aroso, Ivo; Silva, Joana M.; Lima, Estêvão; Reis, Rui L.. "Insights on the corrosion and encrustation of biodegradable Mg alloys in urinary tract environment". Paper presented in Final FoReCaST Conference, 2021.
  3. Pacheco, Margarida; Aroso, Ivo M.; Joana Silva (5919-006C-53B8); Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "URETERAL STENTING USING BIODEGRADABLE METALS". Paper presented in TERM-STEM 2019, 2019.
  4. Pacheco, Margarida; Joana Silva (5919-006C-53B8); Aroso, Ivo M.; Eduardo Silva (521D-E545-32BC ); Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "Curcumin impregnation by supercritical fluid technology in silicon based ureteral stents". Paper presented in FoReCaST 2nd Workshop, 2019.
  5. Pacheco, Margarida; Barros, Alexandre; Aroso, Ivo M.; Joana Silva (5919-006C-53B8); Reis, Rui L.; Lima, Estêvão. "Drug-eluting Biodegradable Ureteral Stents: Targeting urothelial tumors of upper urinary tract cancer". Paper presented in Computational Approaches to Ureteric Stent Design, 2018.
  6. Pacheco, Margarida; Mário Barroca; Bruno Oliveira; Paulo Veloso; Gustavo Santos; Tony Collins. "Deciphering the role of exposed surface residues in protein stability". Paper presented in I Simpósio em Bioquímica Aplicada 2017, 2017.
Journal article
  1. Pacheco, Margarida; Aroso, Ivo M.; Silva, Joana M.; Lamaka, Sviatlana V.; Bohlen, Jan; Nienaber, Maria; Letzig, Dietmar; et al. "Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent". Journal of Magnesium and Alloys 11 11 (2023): 4301-4324. http://dx.doi.org/10.1016/j.jma.2023.10.002.
    Published • 10.1016/j.jma.2023.10.002
  2. Gomes, Inês V.; Pacheco, Margarida; Nienaber, Maria; Neves, Sara C.; Mei, Di; Barros, Alexandre; Reis, Rui L.; Alves, José L.; Puga, Helder. "Shielding AZ91D-1%Ca from corrosion through ultrasound melt treatment: A study for stent design". Journal of Magnesium and Alloys 11 8 (2023): 2901-2915. http://dx.doi.org/10.1016/j.jma.2023.07.013.
    10.1016/j.jma.2023.07.013
  3. Domingues, Beatriz; Pacheco, Margarida; Cruz, Julia E.; Carmagnola, Irene; Teixeira-Santos, Rita; Laurenti, Marco; Can, Fusun; et al. "Future Directions for Ureteral Stent Technology: From Bench to the Market". Advanced Therapeutics 5 1 (2021): 2100158. http://dx.doi.org/10.1002/adtp.202100158.
    10.1002/adtp.202100158
  4. Mei, Di; Wang, Cheng; Nienaber, Maria; Pacheco, Margarida; Barros, Alexandre; Neves, Sara; Reis, Rui L.; et al. "Corrosion behavior of Mg wires for ureteral stent in artificial urine solution". Corrosion Science 189 (2021): 109567. http://dx.doi.org/10.1016/j.corsci.2021.109567.
    10.1016/j.corsci.2021.109567
  5. Pacheco, Margarida. "ENIUS. European Network of multidisciplinary research to Improve the Urinary Stents. COSTS Actions. CA16217. European Cooperation in Science & Technology". Urolithiasis 48 6 (2020): 553-559. http://dx.doi.org/10.1007/s00240-020-01218-2.
    10.1007/s00240-020-01218-2
  6. Pacheco, Margarida; Barros, Alexandre; Aroso, Ivo M.; Autorino, Riccardo; Lima, Estêvão; Silva, Joana M.; Reis, Rui L.. "Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective". Journal of Biomedical Materials Research Part B: Applied Biomaterials (2020): 1-25. http://dx.doi.org/10.1002/jbm.b.34637.
    Published • 10.1002/jbm.b.34637
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/08/25 Additive manufacturing of biodegradable Mg1%Y-based ureteral stents: Understanding the corrosion under simulated urinary tract environment 15th International Symposium on Biodegradable Metals
(Cetraro, Italy)
2022/10/02 Biodegradable metals for ureteral stents: understanding the degradation profile under simulated urinary tract environment 39th World Congress of Endourology and Uro-technology
(San Diego, United States)
2022/08/28 Towards the development of a biodegradable metallic ureteral stent: Characterizing the corrosion and encrustation tendency of Mg alloys under in vitro urinary tract conditions 14th International Symposium on Biodegradable Metals
Hotel Alicante Golf (Alicante, Spain)
2022/05/18 Inside the corrosion and encrustation trend of biodegradable Mg alloys: towards the development of a biodegradable metallic ureteral stent European Society for Bioresorbable Implants
Danube Private University for Dentistry and Medicine (Krems, Austria)
2022/03/02 Understanding the behaviour of biodegradable Mg alloys under in vivo urinary tract conditions Workshop "Latest Advances in Urinary Stents. Multidisciplinary approach“
ENIUS - European Network of Multidisciplinary Research to Improve the Urinary Stents (Istanbul, Turkey)
2021/10/07 Insights on the degradation and encrustation propensity of biodegradable metals in urinary tract environment II Virtual ENIUS Workshop. Next steps for Urinary Stents Research
ENIUS - European Network of Multidisciplinary Research to Improve the Urinary Stents
2021/03/23 Biodegradable metals for ureteral stents: understanding the degradation profile under simulated urinary tract environment Virtual ENIUS Workshop. Latest advances in Urinary Stents. Biomaterials, Technology and Coatings.
2019/09/26 Anticancer and antibacterial effect of curcumin-loaded ureteral stents Advances in Urinary Stents. Biomaterials, Coatings and Drug Eluting Stents (DES)
European Network of multidisciplinary research to Improve the Urinary Stents (ENIUS) (Lublin, Poland)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/10/28 - 2021/10/29 The conference addressed the most relevant topics related to tissue-engineered models for drug screening, cell/tissue interactions within 3D cell co-cultures, advanced nanotechnology tools in cancer research, and high throughput analysis of cancer biomarkers to decipher the tumorigenesis process and metastasis.
Conference
 Final FoReCaST Conference
Biomaterials Biodegradables and Biomimetics, Portugal
2021/10/14 - 2021/10/15 Talks about the last results of the group on additive manufacturing and 3D printing, as well as the presence of invited speakers, experts in this area.
Meeting
 Additive Manufacturing for the Life Sciences Consortium Meeting
Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Sweden
2021/10/04 - 2021/10/04 Advances in ureteral stents
Conference
 On line CONFERENCE. ENIUS Working Group 4&5
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
2021/09/30 - 2021/09/30 Fluid dynamics in urinary stents
Conference
 Computation simulation, biomedical fluid dynamics in urinary stents
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
2021/09/29 - 2021/09/29 Complications of ureteral stents and stenting on pediatric patients
Conference
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
2021/06/16 - 2021/06/18 Last advances in tissue engineering, regenerative medicine, and stem cells research
Conference
 TERM STEM 2021
Biomaterials Biodegradables and Biomimetics, Portugal
2021/06/14 - 2021/06/16 Hallmarks in cancer and the development of diagnostic tools
Conference
 Third Forecast Workshop
Biomaterials Biodegradables and Biomimetics, Portugal
2019/11/09 - 2019/11/09 This event aimed at disseminating and discussing the most recent discoveries and improvements in urology
Symposium
 2nd Portuguese Symposium on Research and Innovation in Urology
Universidade do Porto Porto Business School, Portugal
2019/07/08 - 2019/07/10 The First Achilles Conference focused on Molecular and biological mechanisms of tendon homeostasis and repair. The event was organized to promote a close interaction between highly skilled experts in the field with students and young researchers interested in key aspects of tendon development, disease and regeneration.
Conference
 First Achilles Conference
Biomaterials Biodegradables and Biomimetics, Portugal
2019/01/08 - 2019/01/21 Cell Culture Lab Training
Other
 Cell Culture Lab Training
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/26 - 2018/10/27 The main objective of this event was to discuss the ultimate developments on the utilization of precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices. Some of the main themes regarding this research topic were adressed, such as supramolecular systems, Cell-ECM interactions, Pathological protein aggregation, Drug-delivery systems, Top-Down Fabrication methodologies, Modulating cell behaviour using mechanical stimuli, among others.
Conference
 Chem2Nature
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/23 - 2018/10/24 This conference themed cutting-edge basic and translational research in skin-related diseases and disorders, promoting the interaction of highly skilled experts in this area, counting also with short presentations from young researchers.
Conference
 Gene2Skin
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/10 - 2018/10/10 Universal Mechanical Testing Equipment Training
Other
 Universal Mechanical Testing Equipment Training
Biomaterials Biodegradables and Biomimetics, Portugal
2018/09/04 - 2018/09/04 Vacuum Oven Training Vacuum Oven Training
Biomaterials Biodegradables and Biomimetics, Portugal
2017/04/07 - 2017/04/10 The objective of this activity was to generate and dissiminate knowledge through seminars from the most prestigious speakers, and by promoting the discussion of various different topics by participants, focusing on the participation of students. Altogether, it was a mean to create opportunities for students to contact with prestigious researchers and expand horizons.
Meeting
 X ENEBIOQ - Ciência nas tuas mãos
Universidade do Minho, Portugal
2017/04 - 2017/04 X ENEBIOQ – Ciência nas Tuas Mãos
Meeting
 X ENEBIOQ – Ciência nas Tuas Mãos
Universidade do Minho, Portugal
2016/04 - 2016/04 Flow Cytometry, from research to clinical applications
Workshop
 Flow Cytometry, from research to clinical applications
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Que plantas utilizaria para a produção de um conservante alimentar?
Other
 iSci Interface Ciência
Universidade do Minho, Portugal
2015 - 2015 VI Jornadas de Bioquímica
Meeting
 VI Jornadas de Bioquímica
Universidade do Minho, Portugal
2014 - 2014 V Jornadas de Bioquímica
Meeting
 V Jornadas de Bioquímica
Universidade do Minho, Portugal
2013 - 2013 IV Jornadas de Bioquímica
Meeting
 IV Jornadas de Bioquímica
Universidade do Minho, Portugal

Scientific expedition

Activity description Institution / Organization
2022/05/09 - 2022/12/17 During this work it is intended to investigate the suitability of Additive Manufacturing (AM) for the development of ureteral stents, using Mg1Y powder. The main objective is to develop a biodegradable metallic ureteral stent. Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Sweden
2021/09/05 - 2021/10/26 Gain expertise on Additive Manufacturing (AM) - Laser Powder Bed Fusion (LPBF) in other to use this technique to develop ureteral stent prototypes. Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Sweden
Distinctions

Award

2021 The Best Research Oral Presentation Award
2019 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2019 Research Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2018 Research Fellowship
Horizon 2020, Belgium