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Joana Branco
Identification

Personal identification

Full name
Joana Branco

Citation names

  • J Branco

Author identifiers

Ciência ID
1418-8CFE-D738
ORCID iD
0000-0002-2104-3742

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2018/12/01 - 2023/02/02
Concluded
Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Unveiling the antifungal resistance mechanisms of the emergent fungal pathogen Candida parapsilosis " (THESIS/DISSERTATION)
2011/11/04 - 2012/11/20
Concluded
Biologia Aplicada (2ºciclo) (Mestrado)
Universidade de Aveiro, Portugal
"Estudo molecular da resistência antifúngica de Candida parapsilosis" (THESIS/DISSERTATION)
16
2007/09/17 - 2011/06/22
Concluded
Biologia (1º ciclo) (Licenciatura)
Universidade de Aveiro, Portugal
"Parâmetros ecofisiológicos em dois clones de Eucaliptus globulus Labill. sujeitos a altas temperaturas" (THESIS/DISSERTATION)
15
Affiliation

Others

Category
Host institution
Employer
2017/01/11 - 2018/11/11 Master Research Fellowship, on project entitled “Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata” [PTDC/BBB-BI Universidade do Porto Faculdade de Medicina, Portugal
2015/07/01 - 2016/09/30 Master Research Fellowship, on project entitled "Consequences of reciprocal control of mistranslation during antifungal immunity" [ANR/IMI-MIC/0041/2012]. Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2013/10/11 - 2015/06/30 Master Research Fellowship, on project entitled "Surveillance of the emergent Candida parapsilosis antifungal resistance" [PTDC/DTP-EPI/1660/2012]. Universidade do Porto Faculdade de Medicina, Portugal
2012/11/15 - 2013/08/15 Scientific Research Fellowship, on project entitled "Improving Debaromyces hansenii biotechnological potential by understanding the impact of CUG mistranslation in stress tolerance" [PTDC/EBB-BIO/1082 Universidade do Porto Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2017/01/11 - 2018/11/30 Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches
PTDC/BBB-BIO/4004/2014
Master Student Fellow
Concluded
2015/07/01 - 2016/09/30 Consequences of reciprocal control of mistranslation during antifungal immunity
ANR/IMI-MIC/0041/2012
Master Student Fellow
Concluded
2013/10/15 - 2015/06/30 Surveillance of the emergent Candida parapsilosis antifungal resistance
PTDC/DTP-EPI/1660/2012
Master Student Fellow
Concluded
2012/11 - 2013/08 Improving Debaromyces hansenii biotechnological potential by understanding the impact of CUG mistranslation in stress tolerance
PTDC/EBB-BIO/108269/2008
Scientific Initiation Fellow
Concluded

Contract

Designation Funders
2018/12/01 - 2022/11/30 Unveiling the antifungal resistance mechanisms of the emergent fungal pathogen Candida parapsilosis
SFRH/BD/135883/2018
Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Journal article
  1. Joana Branco; Isabel M. Miranda; Acácio G. Rodrigues. "Candida parapsilosis Virulence and Antifungal Resistance Mechanisms: A Comprehensive Review of Key Determinants". Journal of Fungi (2023): https://doi.org/10.3390/jof9010080.
    10.3390/jof9010080
  2. Mónica Galocha; Romeu Viana; Pedro Pais; Ana Silva-Dias; Mafalda Cavalheiro; Isabel M. Miranda; Mieke Van Ende; et al. "Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation". Communications Biology (2022): https://doi.org/10.1038/s42003-022-04087-0.
    10.1038/s42003-022-04087-0
  3. Joana Branco. "Clinical azole cross-resistance in Candida parapsilosis is related to a novel MRR1 gain-of-function mutation". Clinical Microbiology and Infection (2022): http://dx.doi.org/10.1016/j.cmi.2022.08.014.
    10.1016/j.cmi.2022.08.014
  4. Branco, Joana; Martins-Cruz, Cláudia; Rodrigues, Lisa; Silva, Raquel M.; Araújo-Gomes, Nuno; Gonçalves, Teresa; Miranda, Isabel M.; Rodrigues, Acácio G.. "The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes". Virulence 12 1 (2021): 601-614. http://dx.doi.org/10.1080/21505594.2021.1878743.
    Open access • Published • 10.1080/21505594.2021.1878743
  5. Miranda, Isabel Marcos; Branco, Joana; Oliveira, Patricia; Faria-Ramos, Isabel; Silva, Raquel M.; Rodrigues, Acácio Gonçalves; Costa-de-Oliveira, Sofia. "FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-68706-8.
    Open access • Published • 10.1038/s41598-020-68706-8
  6. Pedrosa, Ana Filipa; Lisboa, Carmen; Branco, Joana; Almeida, Ana C.; Mendes, Claudia; Pellevoisin, Christian; Leite-Moreira, Adelino; Miranda, Isabel M.; Rodrigues, Acacio G.. "Malassezia colonisation on a reconstructed human epidermis: Imaging studies". Mycoses 62 12 (2019): 1194-1201. http://dx.doi.org/10.1111/myc.13011.
    Published • 10.1111/myc.13011
  7. Pedrosa, Ana F.; Lisboa, Carmen; Branco, Joana; Pellevoisin, Christian; Miranda, Isabel Marcos; Rodrigues, Acacio G.. "Malassezia interaction with a reconstructed human epidermis: Keratinocyte immune response". Mycoses 62 10 (2019): 932-936. http://dx.doi.org/10.1111/myc.12965.
    Published • 10.1111/myc.12965
  8. Branco, J.; Ola, M.; Silva, R.M.; Fonseca, E.; Gomes, N.C.; Martins-Cruz, C.; Silva, A.P.; et al. "Impact of ERG3 mutations and expression of ergosterol genes controlled by UPC2 and NDT80 in Candida parapsilosis azole resistance". Clinical Microbiology and Infection 23 8 (2017): 575.e1-575.e8. http://dx.doi.org/10.1016/j.cmi.2017.02.002.
    Published • 10.1016/j.cmi.2017.02.002
  9. Branco, Joana; Silva, Ana P.; Silva, Raquel M.; Silva-Dias, Ana; Pina-Vaz, Cidália; Butler, Geraldine; Rodrigues, Acácio G.; Miranda, Isabel M.. "Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations inMRR1Transcription Factor Gene". Antimicrobial Agents and Chemotherapy 59 10 (2015): 6629-6633. http://dx.doi.org/10.1128/aac.00842-15.
    Published • 10.1128/aac.00842-15
  10. Silva-Dias, Ana; Miranda, Isabel M.; Branco, Joana; Monteiro-Soares, Matilde; Pina-Vaz, Cidália; Rodrigues, Acácio G.. "Adhesion, biofilm formation, cell surface hydrophobicity, and antifungal planktonic susceptibility: relationship among Candida spp.". Frontiers in Microbiology 6 (2015): http://dx.doi.org/10.3389/fmicb.2015.00205.
    Published • 10.3389/fmicb.2015.00205
  11. Silva-Dias, A.; Miranda, I. M.; Branco, J.; Cobrado, L.; Monteiro-Soares, M.; Pina-Vaz, C.; Rodrigues, A. G.. "In vitro antifungal activity and in vivo antibiofilm activity of cerium nitrate against Candida species". Journal of Antimicrobial Chemotherapy (2015): http://dx.doi.org/10.1093/jac/dku511.
    Published • 10.1093/jac/dku511
  12. Silva-Dias, A.; Palmeira-de-Oliveira, A.; Miranda, I. M.; Branco, J.; Cobrado, L.; Monteiro-Soares, M.; Queiroz, J. A.; Pina-Vaz, C.; Rodrigues, A. G.. "Anti-biofilm activity of low-molecular weight chitosan hydrogel against Candida species". Medical Microbiology and Immunology 203 1 (2013): 25-33. http://dx.doi.org/10.1007/s00430-013-0311-4.
    Published • 10.1007/s00430-013-0311-4
Thesis / Dissertation
  1. Branco, Joana Alexandra Vilarinho. "Estudo molecular da resistência antifúngica de Candida parapsilosis". Master, 2012. http://hdl.handle.net/10773/9507.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/07 Candida parapsilosis clinical azole cross-resistance acquisition is prompted by MRR1 gain-of-function mutation 31st European Congress of Clinical Microbiology and Infectious Diseases
2015/04 Micafungin: the best antifungal for treatment of C. parapsilosis complex biofilms 25th European Congress of Clinical Microbiology and Infectious Diseases
European Society of Clinical Microbiology and Infectious Diseases (Copenhaga, Denmark)
2014/07 Elucidating the role of MRR1 transcription factor mutations in Candida parapsilosis azole resistance XX Jornadas de Biologia de Leveduras ”Professor Nicolau van Uden”
Sociedade Portuguesa de Microbiologia (Lisboa, Portugal)
2014/07 Elucidating the role of CUG mistranslation in Debaromyces hansenii stress tolerance XX Jornadas de Biologia de Leveduras ”Professor Nicolau van Uden”
Sociedade Portuguesa de Microbiologia (Lisboa, Portugal)
2014/07 In vitro indeced resistance to azoles, echinocandins and amphotericin B in Candida glabrata XX Jornadas de Biologia de Leveduras ”Professor Nicolau van Uden”
Sociedade Portuguesa de Microbiologia (Lisboa, Portugal)
2010/03 Impact of high temperature on photosynthesis, carbon metabolism and lipid peroxidation of Cork Oak plants 24th IUFRO Conference for Specialists in Air Pollution and Climate Change Effects on Forest Ecosystems
International Union of Forest Research Organizations (Antália, Turkey)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/06/20 - 2021/06/24 Poster - G1810A Gain-of-function Mutation in Mrr1 transcription factor is responsible for azole resistance acquisition by Candida parapsilosis following fluconazole treatment
Congress
World Microbe Forum (Digital Event)
2021/03/21 - 2021/03/27 Poster - Candida parapsilosis virulence attributes expression is repressed by NDT80 transcription factor.
Congress
Candida and Candidiasis Meeting (Digital Event)
2019/12/05 - 2019/12/07 Poster - Decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure
Congress
Microbiotec19 – Congress of Microbiology and Biotechnology
Universidade de Coimbra, Portugal
2019/12/05 - 2019/12/07 Poster - Candida parapsilosis virulence attributes are regulated by NDT80
Congress
Microbiotec19 – Congress of Microbiology and Biotechnology
Universidade de Coimbra, Portugal
2019/07/08 - 2019/07/10 Poster - Malassezia clinical isolates interaction with a reconstructed human epidermis
Meeting
Encontro com a Ciência e Tecnologia em Portugal
2019/07/08 - 2019/07/10 Poster - Role of NDT80 transcription factor in Candida parapsilosis virulence
Meeting
Encontro com a Ciência e Tecnologia em Portugal
2018/04/21 - 2018/04/24 Poster - In vivo cross-resistance acquisition to azoles by Candida parapsilosis
Congress
28th European Congress of Clinical Microbiology and Infectious Diseases
2015/06/07 - 2015/06/11 Poster - Elucidating the role of UPC2 and NDT80 transcription factors in Candida parapsilosis azole resistance
Congress
6th FEMS Congress of European Microbiologists
2015/06/07 - 2015/06/11 Poster - A gain-of-function mutation in the MRR1 transcription factor confers C. parapsilosis voriconazole resistance
Congress
6th FEMS Congress of European Microbiologists
2015/06/07 - 2015/06/11 Poster - Surveillance of Candida parapsilosis antifungal resistance
Congress
6th FEMS Congress of European Microbiologists
2015/06/07 - 2015/06/11 Poster - Candida glabrata phenotypic switching and its association with echinocandins antifungal resistance
Congress
6th FEMS Congress of European Microbiologists. Maastricht
2015/04/25 - 2015/04/28 Poster - Micafungin: the best antifungal for treatment of C. parapsilosis complex biofilms
Congress
25th European Congress of Clinical Microbiology and Infectious Diseases
2015/04/25 - 2015/04/28 Poster - Candida glabrata phenotypic switching: a predictor for echinocandins antifungal resistance development.
Congress
25th European Congress of Clinical Microbiology and Infectious Diseases
2015/04 - 2015/04 Poster - Gain-of-function mutation in MRR1 transcription factor is responsible for C. parapsilosis azole resistance
Congress
25th European Congress of Clinical Microbiology and Infectious Diseases
2014/07/11 - 2014/07/12 Poster - Prevalence of Candida parapsilosis antifungal resistance
Congress
XX Jornadas de Biologia de Leveduras ”Professor Nicolau van Uden”
2014/05/10 - 2014/05/13 Poster - Candida parapsilosis antifungal resistance: a Portuguese surveillance survey
Congress
24th European Congress of Clinical Microbiology and Infectious Diseases
2014/05/10 - 2014/05/13 Poster - Development of antifungal resistance in Candida glabrata and its relationship with phenotypic switching
Congress
24th European Congress of Clinical Microbiology and Infectious Diseases
2013/08/29 - 2013/09/03 Poster - A new molecular tool for gene disruption in Debaromyces hansenii
Conference
26th International Conference on Yeast Genetics and Molecular Biology
2013/08/29 - 2013/09/03 Poster - CUG mistranslation affects stress response in Debaromyces hansenii
Conference
26th International Conference on Yeast Genetics and Molecular Biology
2012/03/31 - 2012/04/03 Poster - Cerium Nitrate: Anti-Candida albicans activity in Planktonic cells and Biofilms
Congress
22nd European Congress of Clinical Microbiology and infectious Diseases
2011/10/02 - 2011/10/05 Poster - Antimicrobial and Anti-Biofilm activity of low molecular weight Chitosan against Candida species
Congress
5th Trends in medical mycology
2011/10/02 - 2011/10/05 Poster - Cerium Nitrate: anti-Candida activity due to cell membrane damage
Congress
5th Trends in medical mycology
2010/07/04 - 2010/07/09 Poster - Analysing the impact of high temperature in ecophysiological parameters of two Eucalyptus globulus clones
Congress
17th Congress of the Federation of European Societies of Plant Biology
Distinctions

Other distinction

2015 Young Scientist Meeting Grant (YSMG)
Federation Of European Microbiological Societies, Netherlands
2015 Young Scientist Meeting Grant (YSMG)
European Society of Clinical Microbiology and Infectious Diseases, Switzerland
2013 Young Scientist Meeting Grant (YSMG)
Federation Of European Microbiological Societies, Netherlands