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Xavier Nissan holds a PhD in Cellular and Molecular Biology (2010) by the Université d'Evry Val d'Essonne. He is presently the Research Director of the Progeria project at the Institute for Stem Cell Therapy and Exploration of Monogenic Diseases in Evry, France. His research interests are in developing novel treatments for Hutchinson–Gilford progeria syndrome based on stem cell technology.
Identification

Personal identification

Full name
Nissan Xavier

Citation names

  • Xavier, Nissan

Author identifiers

Ciência ID
151A-F618-469E
ORCID iD
0000-0003-3374-6274

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Clinical Medicine - Dermatology and Venereal Diseases
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian
Education
Degree Classification
2009
Concluded
 Molecular and cellular biology (Doutoramento)
Evry University, France
"Biologia celular e molecular" (THESIS/DISSERTATION)
 n/a
2004
Concluded
 Aging pharmacology and biology (Pós-Graduação)
Paris VII University, France
"Farmacologia e biologia do envelhecimento " (THESIS/DISSERTATION)
 n/a
2003
Concluded
 Cellular Biology (Mestrado)
Paris VII University, France
"n/a" (THESIS/DISSERTATION)
 n/a
2001
Concluded
 DEUG (Two-year university degree) in science (Diploma de especialização)
Paris VII University, France
"Cellular biology" (THESIS/DISSERTATION)
 n/a
1999
Concluded
 Diploma Ensino Secundário (Ensino secundário)
Yabné School, France
"n/a" (THESIS/DISSERTATION)
 n/a
Affiliation

Others

Category
Host institution 		Employer
2009/03/01 - Current Head of progeria team. Set up an in vitro model of progeria syndrome and identification of new molecular mechanisms. Use of hPSC for drug discovery applications. Development of HTS assays. I-Stem, France
2007/01/01 - 2009/12/31 PhD student Development of protocols to differentiate hPSC into keratinocytes and melanocytes to model genetic skin diseases. Study of the role of microRNAs in PSC differentiation. I-Stem, France
2005/01/01 - 2007/12/31 Platform manager. Executive chief of the institute’s qPCR and microRNAs platform. Development of HTS alternative splicing assay based on qPCR technologies. Development of bioreactor culture systems. I-Stem, France
2004/01/01 - 2004/10/31 Researcher in DT-MTS screening department. Design, analysis and implementation of screening process. Developing HTS assay (Cell-based assays). Optimization of fluorescent uptake assay Sanofi-Synthelabo AB, France
2002/01/01 - 2002/12/01 Internship in the UMR 7592 unity of the Jacques Monod Institute Institut Jacques Monod, France
2001/01/01 - 2001/12/31 Internship in C.E.R.T.O / Biochemistry and genetics department Hôpital universitaire Necker-Enfants malades, France
Outputs

Publications

Journal article
  1. Xavier, Nissan. "Identification of thiostrepton as a pharmacological approach to rescue misfolded alpha-sarcoglycan mutant proteins from degradation". Scientific Reports (2019): http://dx.doi.org/10.1038/s41598-019-43399-w.
    10.1038/s41598-019-43399-w
  2. Xavier, Nissan. "Substrate Topography Modulates Cell Aging on a Progeria Cell Model". ACS Biomaterials Science & Engineering (2018): http://dx.doi.org/10.1021/acsbiomaterials.8b00224.
    10.1021/acsbiomaterials.8b00224
  3. Harhouri K; Navarro C; Depetris D; Mattei MG; Nissan X; Cau P; De Sandre-Giovannoli A; Lévy N. "MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation.". (2017): http://europepmc.org/abstract/med/28674081.
    10.15252/emmm.201607315
  4. Ribas J; Zhang YS; Pitrez PR; Leijten J; Miscuglio M; Rouwkema J; Dokmeci MR; et al. "Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.". (2017): http://europepmc.org/abstract/med/28211642.
    10.1002/smll.201603737
  5. Anne-Laure Egesipe; Sophie Blondel; Alessandra Lo Cicero; Anne-Laure Jaskowiak; Claire Navarro; Annachiara De Sandre-Giovannoli; Nicolas Levy; Marc Peschanski; Xavier Nissan. "Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells". npj Aging and Mechanisms of Disease 2 1 (2016): https://doi.org/10.1038/npjamd.2016.26.
    10.1038/npjamd.2016.26
  6. Lo Cicero A; Jaskowiak AL; Egesipe AL; Tournois J; Brinon B; Pitrez PR; Ferreira L; et al. "A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.". (2016): http://europepmc.org/abstract/med/27739443.
    10.1038/srep34798
  7. Blondel S; Egesipe AL; Picardi P; Jaskowiak AL; Notarnicola M; Ragot J; Tournois J; et al. "Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.". (2016): http://europepmc.org/abstract/med/26890144.
    10.1038/cddis.2015.374
  8. Lo Cicero A; Nissan X. "Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery.". (2015): http://europepmc.org/abstract/med/26474742.
    10.1016/j.arr.2015.10.002
  9. Laustriat D; Gide J; Barrault L; Chautard E; Benoit C; Auboeuf D; Boland A; et al. "In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin.". (2015): http://europepmc.org/abstract/med/26528939.
    10.1038/mtna.2015.35
  10. Allouche J; Bellon N; Saidani M; Stanchina-Chatrousse L; Masson Y; Patwardhan A; Gilles-Marsens F; et al. "In vitro modeling of hyperpigmentation associated to neurofibromatosis type 1 using melanocytes derived from human embryonic stem cells.". (2015): http://europepmc.org/abstract/med/26150484.
    10.1073/pnas.1501032112
  11. Nissan X. "Pluripotent stem cells for pathological modelling of Hutchinson-Gilford Progeria Syndrome (HGPS) and drug discovery.". (2015): http://europepmc.org/abstract/PMC/PMC4652534.
    10.1186/1750-1172-10-s2-o2
  12. Blondel S; Jaskowiak AL; Egesipe AL; Le Corf A; Navarro C; Cordette V; Martinat C; et al. "Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome.". (2014): http://europepmc.org/abstract/med/24598781.
    10.5966/sctm.2013-0168
  13. Nissan X; Blondel S; Navarro C; Maury Y; Denis C; Girard M; Martinat C; et al. "Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA.". Cell Reports (2012): http://europepmc.org/abstract/med/22840390.
    10.1016/j.celrep.2012.05.015
  14. Boissart C; Nissan X; Giraud-Triboult K; Peschanski M; Benchoua A. "miR-125 potentiates early neural specification of human embryonic stem cells.". (2012): http://europepmc.org/abstract/med/22357933.
    10.1242/dev.073627
  15. Blondel S; Navarro C; Lévy N; Peschanski M; Nissan X. "[miR-9: the sentinel of neurons in progeria].". (2012): http://europepmc.org/abstract/med/22805145.
    10.1051/medsci/2012286022
  16. Nissan X; Blondel S; Peschanski M. "In vitro pathological modelling using patient-specific induced pluripotent stem cells: the case of progeria.". (2011): http://europepmc.org/abstract/med/22103524.
    10.1042/bst20110659
  17. Nissan X; Lemaitre G; Peschanski M; Baldeschi C. "Coloring skin with pluripotent stem cells.". (2011): http://europepmc.org/abstract/med/22101274.
    10.4161/cc.10.23.18249
  18. Nissan X; Lemaitre G; Peschanski M; Baldeschi C. "[Melanocytes derived from pluripotent stem cells: a new biological resource for pigmentary disorders].". (2011): http://europepmc.org/abstract/med/22130018.
    10.1051/medsci/20112711007
  19. Nissan X; Larribere L; Saidani M; Hurbain I; Delevoye C; Feteira J; Lemaitre G; Peschanski M; Baldeschi C. "Functional melanocytes derived from human pluripotent stem cells engraft into pluristratified epidermis.". (2011): http://europepmc.org/abstract/med/21856949.
    10.1073/pnas.1019070108
  20. Nissan X; Denis JA; Saidani M; Lemaitre G; Peschanski M; Baldeschi C. "miR-203 modulates epithelial differentiation of human embryonic stem cells towards epidermal stratification.". (2011): http://europepmc.org/abstract/med/21684271.
    10.1016/j.ydbio.2011.06.004
  21. Lemaître G; Nissan X; Baldeschi C; Peschanski M. "Concise review: Epidermal grafting: the case for pluripotent stem cells.". (2011): http://europepmc.org/abstract/med/21472820.
    10.1002/stem.636
  22. Giraud-Triboult K; Rochon-Beaucourt C; Nissan X; Champon B; Aubert S; Piétu G. "Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1.". (2011): http://europepmc.org/abstract/med/21081659.
    10.1152/physiolgenomics.00077.2010
  23. Peschanski M; Lemaitre G; Nissan X; Baldeschi C. "Epidermis grafting: from adult to embryonic stem cells.". (2010): http://europepmc.org/abstract/med/20210574.
    10.2217/rme.10.8
  24. Nissan X; Lemaitre G; Peschanski M; Baldeschi C. "[Pluristratified epidermis from human embryonic stem cells].". (2010): http://europepmc.org/abstract/med/20132761.
    10.1051/medsci/20102615
  25. Guenou H; Nissan X; Larcher F; Feteira J; Lemaitre G; Saidani M; Del Rio M; et al. "Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study.". (2009): http://europepmc.org/abstract/med/19932355.
    10.1016/s0140-6736(09)61496-3
  26. Côme J; Nissan X; Aubry L; Tournois J; Girard M; Perrier AL; Peschanski M; Cailleret M. "Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system.". (2008): http://europepmc.org/abstract/med/18710335.
    10.1089/ten.tec.2008.0029

Intellectual property

Patent
  1. Xavier, Nissan. 2011. "Methods for preparing human melanocytes from pluripotent stem cells.".
Distinctions

Other distinction

2012 Price Chouroulinkov
2011 Travel Award
2009 Travel Award