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Graciosa Quelhas Teixeira is a Biomedical Engineer and Postdoctoral Researcher at the Institute of Orthopaedic Research and Biomechanics (UFB), Ulm University, Germany, since 2017. UFB is an institution with recognized contributions to the scientific community, renowned in the spine field and with a close connection to the society and the needs in the field. Her main research interests focus on better understanding the mechanobiology of the intervertebral disc (IVD) and meniscus, and the inflammatory response associated with disc degeneration, as well as contributing to the development of new strategies for disc and meniscus regeneration. Graciosa collaborates/collaborated in 9 national and international projects and is/was principal investigator of 5 projects. She is involved in the development of new study models of human, bovine and mouse IVD and meniscus, with focus on the complement system activation and annulus fibrosus biomechanics. She is also experienced in stem cell-based tissue engineering strategies and biomaterial testing for IVD applications. In parallel, Graciosa is involved in lecturing at the Ulm University and Ulm University of Applied Sciences. She co-supervises/co-supervised 6 BSc/MSc students, 4 medical doctoral students and several interns. Graciosa contributed to 23 publication in international peer-review journals, 13 as first/last (co-)author. Her publications have been cited 550 times (h-index: 11; SCOPUS - 25/09/2022). She contributed to 96 abstracts accepted for oral communications, posters or special posters, presented in relevant national and international conferences of the respective research areas (ORS, Eurospine, ISSLS, Termis, ESB, among others), in which several studies were awarded. She received multiple national and international awards and scholarships, including the GRAMMER / European Spine Journal Award for Best Paper (Teixeira et al., Eur Spine J, 2021) in 2021. Graciosa is an active member of research societies such as the ISSLS, European Society of Biomechanics, the Orthopaedic Research Society (ORS), the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and the MusculoSkeletal Interdisciplinary Translational Young Researchers (MuSkITYR). She is an active reviewer for the European Spine Journal, among others, and Editor of a Research Topic in Frontiers in Bioengineering and Biotechnology. Graciosa is also Ambassador for the ExzellenziaUlm LinkedIn group for young female academics of the Ulm University.
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Identification

Personal identification

Full name
GRACIOSA PATRÍCIA QUELHAS TEIXEIRA

Citation names

  • Teixeira, Graciosa Q.
  • Teixeira, Graciosa Quelhas

Author identifiers

Ciência ID
151F-27E6-F098
ORCID iD
0000-0003-4206-6326
Researcher Id
AAM-9925-2020
Scopus Author Id
56432496600

Email addresses

  • graciosa.teixeira@uni-ulm.de (Professional)

Telephones

Telephone
  • (+49) 731 500 Ext.: 55324 (Professional)

Addresses

  • Institute of Orthopaedic Research and Biomechanics, Ulm University, 89081, Ulm, Baden-Württemberg, Germany (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Engineering and Technology - Medical Engineering

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Education
Degree Classification
2012 - 2017
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Modulation of inflammatory response associated with intervertebral disc degeneration" (THESIS/DISSERTATION)
2016 - 2016
Concluded
 Introductory Course in Laboratory Animal Science (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2010 - 2012
Concluded
 Engenharia Biomédica (Mestrado)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Establishment of 3D cell cultures under dynamic conditions using a multi-compartment holder for spinner flask" (THESIS/DISSERTATION)
 17/20
2007 - 2010
Concluded
 Bioengenharia (Licenciatura)
Major in Engenharia Biomédica
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
 17/20
Affiliation

Science

Category
Host institution 		Employer
2017/09/01 - Current Postdoc (Research) Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2017/03/01 - 2017/08/31 Research Assistant (Research) Instituto Nacional de Engenharia Biomédica, Portugal
2013/04 - 2014/06 Visiting Researcher (Research) Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
Projects

Grant

Designation Funders
2020/06 - Current Does complement deficiency influence intervertebral disc phenotype? Insights from C6 and CD59 deficient mice organ culture investigations
n/a
Principal investigator
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 International Society for the Study of the Lumbar Spine
Ongoing
2022/02 - 2024/01 Therapeutic role of extracellular vesicles secreted by IL-1ß-primed mesenchymal stem cells for meniscus regeneration
n/a
Principal investigator
Ongoing
2022/01 - 2022/12 Stem cell-produced extracellular vesicles to promote intervertebral disc regeneration
n/a
Post-doc Fellow
Universität Ulm
Ongoing
2020/12 - 2022/11 Complement modulation by cell-free MSC secretome as a new therapeutic option for intervertebral disc degeneration? Studies on murine spine organ cultures
n/a
Co-Principal Investigator (Co-PI)
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 Deutsche Wirbelsäulengesellschaft
Ongoing
2021/07 - 2022/08 Effect of 17ß-estradiol and low-magnitude high-frequency vibration on intervertebral disc degeneration
KNMÜ.031.02
Principal investigator
Universität Ulm Medizinische Fakultät
Concluded
2018/04 - 2020/07 Mesenchymal stem cell-based therapies for intervertebral disc herniation: effect on complement system activation and annulus fibrosus biomechanics
LSBN.0157
Principal investigator
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 Universität Ulm
Concluded
2013/03 - 2017/02 Modulation of inflammatory response associated with intervertebral disc degeneration
SFRH/BD/88429/2012
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/10 - Current Coupled analysis of active biological processes for meniscus tissue regeneration
SE 3135/3-1
Researcher
Deutsche Forschungsgemeinschaft
Ongoing
2017/09 - 2022/08 Role of the terminal complement complex (TCC) in disc degeneration
NE 549/6-1
Researcher
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 Deutsche Forschungsgemeinschaft
Concluded

Other

Designation Funders
2019/01 - Current Induced pluripotent stem cell-based therapy for spinal regeneration (iPSpine)
iPSpine H2020-EU.3.1.3. (825925)
Researcher
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 European Commission
Ongoing
2017/09 - Current Third-party funded projects with industry support
n/a
Researcher
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2017/09 - 2018/09 Investigations on the pathomechanism of disc herniation by in vitro simulation of inflammation and mechanical loading in a cell culture and organ culture model of the anulus fibrosus
n/a
Researcher
Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
 Deutsche Wirbelsäulengesellschaft
2017/03 - 2018/08 Biomechanics of Intervertebral Disc treated with Anti-inflammatory Therapies
57339602
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
Conselho de Reitores das Universidades Portuguesas

Deutscher Akademischer Austauschdienst
Concluded
2015/07 - 2017/08 Approaching Intervertebral Disc Regeneration by Mesenchymal Stem Cells Recruitment
IF/00638/2014
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/09 - 2016/08 Stem cells paracrine action for intervertebral disc regeneration
n/a
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 EUROSPINE The Spine Society of Europe
Concluded
2012/04 - 2014/06 Simulation of new disc regeneration therapies in an organ culture
n/a
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
Conselho de Reitores das Universidades Portuguesas

Deutscher Akademischer Austauschdienst
Concluded
2011/09 - 2012/12 BIOMATRIX: Multifunctional extracellular matrix-analogues as biomaterials for bone regeneration
PTDC/SAU-BEB/101235/2008/FCOMP-01-0124-FEDER-010915
Researcher
Instituto Nacional de Engenharia Biomédica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Galbusera, F.; Teixeira, Graciosa Q.. "Intervertebral disc biomechanics". In Human Orthopaedic Biomechanics: Fundamentals, Devices and Applications, edited by Innocenti, B.; Galbusera, F.. Amsterdam, Netherlands: Elsevier, 2021.
    In press
  2. Teixeira, Graciosa Q.; Höpfner, Yana; Neidlinger-Wilke, Cornelia. "Fundamentals of mechanobiology". In Human Orthopaedic Biomechanics: Fundamentals, Devices and Applications, edited by Innocenti, B.; Galbusera, F.. Amsterdam, Netherlands: Elsevier, 2021.
    In press
  3. Teixeira, Graciosa Q.; Barbosa, Mário Adolfo; Gonçalves, Raquel M.. "Immunomodulation in Degenerated Intervertebral Disc". In Gene and Cell Delivery for Intervertebral Disc Degeneration, edited by Gonçalves, Raquel M.; Barbosa, Mário Adolfo, 183-230. CRC Press, 2018.
    Published • 10.1201/9781351030182-7
Conference abstract
  1. Jansen JU, Teixeira G, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke H. "Jansen JU, Teixeira G, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke H, How to mimic disc degeneration for in vitro experiments to test regenerative approaches? Usage of chondroitinase versus papain. ISSLS Annual Meeting, 9-13 May 2022, Boston, Massachusetts, USA.". 2022.
  2. Teixeira GQ, Höpfner Y, Ostertag J, Riegger J, Ignatius A, R. Brenner R, Neidlinger-Wilke C. "Teixeira GQ, Höpfner Y, Ostertag J, Riegger J, Ignatius A, R. Brenner R, Neidlinger-Wilke C, Terminal complement complex formation in C6-deficient and CD59-knockout mice during disc aging and degeneration. ISSLS Annual Meeting, 9-13 May 2022, Boston, Massachusetts, USA.". 2022.
  3. Jansen JU, Teixeira GQ, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke HJ. "Jansen JU, Teixeira GQ, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke HJ, How to create artificial disc degeneration by enzyme digestion for biomechanical testing of biomaterials. eCM20: Cartilage and Disc Repair and Regeneration, 15-18 June 2022, Davos, Switzerland.". 2022.
  4. Riegger J, Ruths L, Teixeira G, Huber-Lang M, Ignatius A, Brenner RE. "Riegger J, Ruths L, Teixeira G, Huber-Lang M, Ignatius A, Brenner RE, Terminal complement complex is a potential inducer of premature senescence in trauma- and age-associated osteoarthritis. eCM20: Cartilage and Disc Repair and Regeneration, 15-18 June 2022, Davos, Switzerland.". 2022.
  5. Teixeira GQ, Kräutler J, Riegger J, Ignatius A, Neidlinger-Wilke C. "Teixeira GQ, Kräutler J, Riegger J, Ignatius A, Neidlinger-Wilke C, Effect of entire MSC secretome versus extracellular vesicles in pro-inflammatory annulus fibrosus cell cultures. eCM20: Cartilage and Disc Repair and Regeneration, 15-18 June 2022, Davos, Switzerland.". 2022.
  6. de Roy L, Piquet O, Teixeira G, Weiske MF, Mayr HO, Seidenstuecker M, Seitz AM. "de Roy L, Piquet O, Teixeira G, Weiske MF, Mayr HO, Seidenstuecker M, Seitz AM, The in-vitro test conditions influence the biomechanical properties of degenerated lateral menisci. 27th Congress of the European Society of Biomechanics, 26-29 June 2022, Porto, Portugal.". 2022.
  7. Jansen JU, Teixeira GQ, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke HJ. "Jansen JU, Teixeira GQ, Vernengo A, Grad S, Benz K, Neidlinger-Wilke C, Wilke HJ, In vitro testing of hydrogels for the IVD therapy using a novel organ culture approach: chondroitinase or papain?. 27th Congress of the European Society of Biomechanics, 26-29 June 2022, Porto, Portugal.". 2022.
  8. Teixeira GQ, Schwer J, Ignatius A, Dürselen L, Seitz AM. "Teixeira GQ, Schwer J, Ignatius A, Dürselen L, Seitz AM, Age-related degeneration affects the structure-function relationship of human menisci. 27th Congress of the European Society of Biomechanics, 26-29 June 2022, Porto, Portugal.". 2022.
  9. "Teixeira GQ, Goncalves RM, Ignatius A, Wilke HJ, Neidlinger-Wilke C, The secretome of preconditioned MSCs modulates matrix degradation by human anulus fibrosus cells exposed to mechanical stress and inflammatory conditions. 16th German Spine Conference, 9-11 December 2021, Münster, Germany: Eur Spine J 30, 3343 (2021). doi: 10.1007/s00586-021-07017-6". 2021.
  10. "Castro A, Ribeiro-Machado C, Oliveira C, Pereira P, Vaz R, Teixeira GQ, Neidlinger-Wilke C, Barbosa M, Goncalves R, Dissecting fibrosis in human annulus fibrosus after intervertebral disc herniation. TERMIS 6th World Congress, 15-19 November 2021, Virtual.". 2021.
  11. "Teixeira GQ, Yong Z, Kuhn A, Riegger J, Ruf M, Ignatius A, Brenner R, Neidlinger-Wilke C, Interleukin-1ß and cathepsin-D modulate the terminal complement complex formation in human disc tissue cultures. TERMIS 6th World Congress, 15-19 November 2021, Virtual.". 2021.
  12. "Jansen JU, Teixeira GQ, Vernengo A, Grad S, Neidlinger-Wilke C, Wilke HJ, Chondroitinase versus Papain digestion leads to different outcome for in vitro simulation of degenerated discs. EUROSPINE Annual Meeting, 6-8 October 2021, Vienna, Austria: Brain and Spine 1 (2021) S2–S3.". 2021.
  13. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Brisby H, Henriksson HB, Ruf M, Barth T, Mauer UM, Ignatius A, Brenner RE, Neidlinger-Wilke C, Terminal complement complex formation is associated with intervertebral disc degeneration. EUROSPINE Annual Meeting, 6-8 October 2021, Vienna, Austria. [GRAMMER/European Spine Journal Best Paper Award 2020/21 Presentation]". 2021.
  14. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Immunomodulatory effect of stem cell secretome in a loaded annulus fibrosus organ culture. EUROSPINE Annual Meeting, 6-8 October 2021, Vienna, Austria: Brain and Spine 1 (2021) S10.". 2021.
  15. "Kuhn A, Riegger J, Teixeira GQ, Ruf M, Neidlinger-Wilke C, Brenner R, Inhibition of terminal complement complex deposition on intervertebral disc cells using eculizumab. German Congress of Orthopaedics and Trauma Surgery (DKOU), 26-29 October, Berlin, Germany. doi: 10.3205/21dkou393". 2021.
  16. "Teixeira GQ, Yong Z, Kuhn A, Ruf M, Ignatius A, Brenner R, Neidlinger-Wilke C, Terminal complement complex formation in human disc tissue cultures. German Congress of Orthopaedics and Trauma Surgery (DKOU), 26-29 October, Berlin, Germany. doi: 10.3205/21dkou395". 2021.
  17. "Jansen JU, Teixeira GQ, Vernengo A, Grad S, Neidlinger-Wilke C, Wilke HJ, Enzymatic digestion with chondroitinase or papain: methods to induce disc degeneration for in vitro testing? 26th Congress of the European Society of Biomechanics, 11-14 July 2021, Virtual.". 2021.
  18. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Stem cell secretome decreases annular mechanical strength in a loaded annulus fibrosus organ culture. 26th Congress of the European Society of Biomechanics, 11-14 July 2021, Virtual.". 2021.
  19. "Teixeira GQ, Höpfner Y, Ostertag J, Neidlinger-Wilke C, Does complement deficiency influence intervertebral disc phenotype? Insights from C6 and CD59 deficient mice organ culture investigations. ISSLS Annual Meeting, 1-4 June 2021, Virtual. [Fellowship Award presentation, invited]". 2021.
  20. Teixeira, Graciosa Q.. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Potential of MSC secretome to modulate degenerative changes in a loaded annulus fibrosus organ culture model. ISSLS Annual Meeting, 1-4 June 2021, Virtual, accepted.". 2021.
  21. Teixeira, Graciosa Q.. "Wilke HJ, Zengerle L, Zöllner L, Teixeira G, Neidlinger-Wilke C, Pressure characteristic in lumbar discs correlate with degeneration but not necessarily with the proteoglycan content. ISSLS Annual Meeting, 1-4 June 2021, Virtual, accepted.". 2021.
  22. Teixeira, Graciosa Q.. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Höpfner Y, Nothelfer J, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSC secretome decreases pro-inflammatory response in loaded AF organ cultures. 15th German Spine Conference, 9-11 December 2020, Virtual: Eur Spine J; 2020. p. 2871.". 2020.
  23. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Kuhn A, Riegger J, Ruf M, Ignatius A, Brenner R, Neidlinger-Wilke C, Can disc degeneration-associated factors activate terminal complement complex (TCC) formation? 15th German Spine Conference, 9-11 December 2020, Virtual: Eur Spine J; 2020. p. 2870-1.". 2020.
  24. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Kuhn A, Ruf M, Mauer UM, Ignatius A, Brenner R, Neidlinger-Wilke C, Modulation of the terminal complement complex formation in human disc tissue cultures. EUROSPINE Virtual Meeting, 6-9 October 2020.". 2020.
  25. Teixeira, Graciosa Q.. "Ferreira J, Teixeira GQ, Barbosa MA, Goncalves RM, Dissecting mesenchymal stem/stromal cells secretome to modulate the inflammatory response of degenerated intervertebral disc. 7th BioSpine Congress, 3-5 April 2019, Rome, Italy". 2019.
  26. Teixeira, Graciosa Q.. "Goncalves RM, Teixeira GQ, Yong Z, Saggese T, Ferreira J, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSCs secretome decreases matrix degrading activity of annulus fibrosus cells under mechanical loading and inflammatory environment. 7th BioSpine Congress, 3-5 April 2019, Rome, Italy". 2019.
  27. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Teixeira GQ, Wilke HJ, Methods for studying mechanobiology, International/American Society of Biomechancis (ISB/ASB) Meeting, 31 July-4 August 2019, Calgary, Canada". 2019.
  28. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Ruf M, Nerlich A, Barth T, Mauer UM, Ignatius A, Brenner R, Neidlinger-Wilke C, Terminal complement complex (TCC): a possible target for in intervertebral disc degeneration therapeutics. EUROSPINE Annual Meeting, 16-18 October 2019, Helsinki, Finland. EUROSPINE 2019: Oral Presentations. Eur Spine J 28, 2761–2804 (2019)". 2019.
    10.1007/s00586-019-06101-2
  29. Teixeira, Graciosa Q.. "Yong Z, Teixeira GQ, Kuhn A, Ruf M, Mauer UM, Ignatius A, Brenner R, Neidlinger-Wilke C, IL-1ß and Cathepsin-D modulate cellular terminal complement complex formation in human disc tissue. 2nd MuskITYR Symposium, 2-3 December 2019, Reisensburg, Germany. [Best Abstract Award]". 2019.
  30. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Ruf M, Nerlich A, Mauer UM, Barth T, Ignatius A, Brenner R, Neidlinger-Wilke C, Terminal complement complex formation in degenerated discs correlates with degree of degeneration. 14th German Spine Conference, 28-30 November 2019, Munich, Germany.". 2019.
  31. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Ruf M, Nerlich A, Mauer UM, Ignatius A, Brenner R, Neidlinger- Wilke C, Is the terminal complement complex a possible target for therapeutic innervation in intervertebral disc degeneration? ISSLS Annual Meeting, 3-7 June 2019, Kyoto, Japan. [Best Paper Award]". 2019.
  32. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Ruf M, Nerlich A, Mauer UM, Ignatius A, Brenner R, Neidlinger- Wilke C, Is the terminal complement complex a target for intervertebral disc degeneration therapeutics? TERMIS-EU Meeting, 27-31 May 2019, Rhodes, Greece: Eur. Cell Mat. Periodical.". 2019.
  33. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Ruf M, Nerlich A, Mauer UM, Ignatius A, Brenner R, Neidlinger- Wilke C, Does the terminal complement complex play a role in disc degeneration? 7th BioSpine Congress, 3-5 April 2019, Rome, Italy.". 2019.
  34. Teixeira, Graciosa Q.. "Saggese T, Moll L, Wade K, Weigl A, Teixeira GQ, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Does inflammatory stimulation and mechanical loading weaken the anulus fibrosus (AF)? Preliminary investigations in a bovine AF organ culture approach. ISSLS Annual Meeting, 14-18 May 2018, Banff, Canada". 2018.
  35. Teixeira, Graciosa Q.. "Castro F, Pinto ML, Silva AM, Pereira CL, Teixeira GQ, Teixeira JH, Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy, 8th International Conference on tumor microenvironment progression, therapy and prevention, 10-14 June 2018, Lisbon, Portugal". 2018.
  36. Teixeira, Graciosa Q.. "Saggese T, Moll L, Wade K, Weigl A, Teixeira GQ, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Inflammatory stimulation and mechanical loading lead to a weakening of the trans-lamellar bridging network of the anulus fibrosis. 8th World Congress of Biomechanics, 8-12 July 2018, Dublin, Ireland". 2018.
  37. Teixeira, Graciosa Q.. "Castro F, Pinto ML, Silva AM, Pereira CL, Teixeira GQ, Teixeira JH, La´zaro MG, Santos SG, Barbosa MA, de Wever O, Serre K, Gonc¸alves RM, Oliveira MJ, Development of biomaterials-based immunotherapy: chitosan and poly(gamma)-glutamic acid nanoparticles as immunomodulatory players at the tumor microenvironment, 29th Annual Congress of the ESB, 9-13 September 2018, Maastricht, Netherlands". 2018.
  38. Teixeira, Graciosa Q.. "Saggese T, Moll L, Wade K, Weigl A, Teixeira GQ, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Combined mechanical and pro-inflammatory stress contributes to weakening of the anulus fibrosus in a bovine AF organ culture approach. EUROSPINE, 19-21 September 2018, Barcelona, Spain". 2018.
  39. Teixeira, Graciosa Q.. "Saggese T, Moll L, Wade K, Weigl A, Teixeira G, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Inflammatory stimulation and mechanical loading lead to a weakening of the trans-lamellar bridging network of the anulus fibrosis. Deutscher Kongress fu¨r Orthopa¨die und Unfallchirurgie (DKOU), 23-26 October 2018, Berlin, Germany". 2018.
  40. Teixeira, Graciosa Q.. "Saggese T, Teixeira GQ, Moll L, Wade K, Ignatius A, Wilke HJ, Goncalves R, Neidlinger-Wilke C, Die Kombination der degenerativen Stressfaktoren mechanische Belastung und Entzu¨ndung tra¨gt zur Schwa¨chung des Anulus fibrosus im bovinen Organkulturmodell bei. 14th German Spine Conference, 6-8 December 2018, Wiesbaden, Germany". 2018.
  41. Teixeira, Graciosa Q.. "Teixeira GQ, Leite Pereira C, Castro F, Ferreira JR, Gomes-Lazaro M, Aguiar P, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Poly(¿-glutamic acid)-based nanoparticles locally control inflammation and promote extracellular matrix remodeling in Intervertebral disc, 6th China-Europe Symposium on Biomaterials in Regenerative Medicine (CESB), 21-24 May 2017, Porto, Portugal". 2017.
  42. Teixeira, Graciosa Q.. "Pereira CL, Teixeira GQ, Caldeira J, D ´Este M, Eglin D, Alini M, Grad S, Barbosa MA, Gonc¸alves RM, Mesenchymal stem/stromal cells recruitment from the cartilaginous endplate: a new perspective for IVD regenerative strategies through ECM remodeling, TERMIS-EU Meeting, 26-30 June 2017, Davos, Switzerland". 2017.
  43. Teixeira, Graciosa Q.. "Teixeira GQ, Ferreira JR, Pereira CL, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Mesenchymal stem/stromal cells immunomodulatory role through a paracrine mechanism in degenerated IVD, TERMIS-EU Meeting, 26-30 June 2017, Davos, Switzerland". 2017.
  44. Teixeira, Graciosa Q.. "Goncalves RM, Teixeira FR, Teixeira GQ, Leite Pereira AC, Antunes JC, Ferreira J, Oliveira MJ, Barbosa MA, Chitosan/Poly-y-Glutamic acid nanoparticles as the backbone of immunomodulatory therapies, 28th European Conference on Biomaterials, 4-8 September 2017, Athens, Greece". 2017.
  45. Teixeira, Graciosa Q.. "Pereira CL, Teixeira G, Caldeira J, D’Este M, Eglin D, Grad S, Barbosa MA, Gonc¸alves RM, Hyaluronan-based hydrogel for SDF-1 delivery in the intervertebral disc: insights from an ex vivo model, 28th European Conference on Biomaterials, 4-8 September 2017, Athens, Greece". 2017.
  46. Teixeira, Graciosa Q.. "Teixeira GQ, Ferreira JR, Pereira CL, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Mesenchymal stem/stromal cells immunomodulatory role in degenerated IVD, 6th Advanced Summer School: The Research/Clinic Interface at the Spine, 19-22 June 2017, Porto, Portugal". 2017.
  47. Teixeira, Graciosa Q.. "Teixeira GQ, Boldt A, Nagl I, Leite Pereira C, Molinos M, Benz K, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger- Wilke C, Gonc¸alves RM, A nanotechnology-based therapy to target inflammation in degenerated intervertebral disc: first results from an ex vivo disc organ culture, Global Spine Congress/World Forum for Spine Research (GSC/WFSR 2016), 13-16 April 2016, Dubai". 2016.
  48. Teixeira, Graciosa Q.. "Leite Pereira C, Teixeira GQ, Caldeira J, Costa M, Figueiredo F, Fernandes R, Aguiar P, Grad S, Barbosa MA, Gonc¸alves RM, Intervertebral disc degeneration: role of migrating mesenchymal stem/stromal cells (MSCs) in extracellular matrix remodelling, TERMIS-EU Meeting, 28 June - 1 July 2016, Uppsala, Sweden". 2016.
  49. Teixeira, Graciosa Q.. "Teixeira GQ, Antunes JC, Leite Pereira C, Castro F, Ferreira JR, Gomez-Lazaro M, Aguiar P, Silva RV, Caldeira J, Neidlinger-Wilke C, Grad S, Barbosa MA, Goncalves RM, Local treatment of inflammation in degenerated intervertebral disc using poly(y-glutamic acid)-based nanocomplexes promotes extracellular matrix remodeling, TERMIS-EU Meeting, 28 June - 1 July 2016, Uppsala, Sweden". 2016.
  50. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Nagl I, Teixeira GQ, Kletsas D, Ignatius A, Chondrogenic differentiation of human bone marrow (MSC) versus adipose tissue derived stem cells (ASC) at pro-inflammatory conditions, EUROSPINE, 5-7 October 2016, Berlin, Germany". 2016.
  51. Teixeira, Graciosa Q.. "Teixeira GQ, Ferreira JR, Molinos M, Leite Pereira C, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Mesenchymal stem/stromal cells present an immunomodulatory role through paracrine mechanism in degenerated but not in healthy IVD, EUROSPINE, 5-7 October 2016, Berlin, Germany". 2016.
  52. Teixeira, Graciosa Q.. "Teixeira GQ, Nagl I, Mollenhauer J, Wilke HJ, Ignatius A, Barbosa MA, Goncalves R, Neidlinger-Wilke C, Does mesenchymal stem cell therapy have the potential to control inflammation in a pro-inflammatory intervertebral disc organ culture system?, 5th BioSpine Congress, 8-11 April 2015, Berlin, Germany". 2015.
  53. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira ACL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Local treatment of inflammation and degeneration of intervertebral disc: ex vivo study of anti-inflammatory drug delivery system based on Chitosan/Poly-(y-Glutamic acid) nanoparticles, 5th BioSpine Congress, 8-11 April 2015, Berlin, Germany". 2015.
  54. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira ACL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, An anti-inflammatory drug delivery system based on Chitosan/Poly-(y-Glutamic acid) nanoparticles to treat inflammation and degeneration of intervertebral disc: an ex vivo study, Society for Biomaterial (SFB) Annual Meeting, 15-18 April 2015, Charlotte, NC, USA". 2015.
  55. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira CL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Goncalves RM, Intradiscal application of anti-inflammatory nanoparticles control inflammation while remodel extracellular matrix of degenerated intervertebral disc, 1st Symposium on Immunomodulation in Cancer & Regeneration, 2 July 2015, Porto, Portugal". 2015.
  56. Teixeira, Graciosa Q.. "Teixeira GPQ, Pereira CL, Benz K, Wilke HJ, Ignatius A, Barbosa MA, Goncalves R, Neidlinger-Wilke C, Comparison of an anti-inflammatory drug delivery system versus MSC therapy to control inflammation in a pro- inflammatory intervertebral disc organ culture system, EUROSPINE, 2-4 September 2015, Copenhagen, Denmark". 2015.
  57. Teixeira, Graciosa Q.. "Antunes JC, Pereira CL, Teixeira GQ, Silva RV, Caldeira J, Grad S, Gonc¸alves RM, Barbosa MA, Poly(¿-glutamic acid) and poly(¿-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc, BIOMAT 2015, 12-14 October 2015, Ile de Re´, France". 2015.
  58. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Teixeira GQ, Pereira CL, Benz K, Wilke HJ, Ignatius A, Barbosa MA, Gonc¸alves R, Comparison of anti-inflammatory therapy concepts in a bovine disc organ culture system, German Congress of Orthopaedics and Trauma Surgery (DKOU), 20-23 October 2015, Berlin, Germany". 2015.
  59. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Nagl I, Teixeira GQ, Kletsas D, Wilke HJ, Ignatius A, Influence of pro-inflammatory stimulation by IL-1ß on chondrogenic differentiation of human mesenchymal stem cells (MSCs) versus adipose- derived stem cells (ASCs). German Spine Conference, 10-12 December 2015, Frankfurt, Germany". 2015.
  60. Rotrekl, D; Vochyánová, Z; Paráková, L; Salon, I; Šalamúnová, P; Hanuš, J; Štepánek, F; Hošek, J. "Neidlinger-Wilke C, Teixeira GQ, Mollenhauer J, Wilke HJ, Ignatius A, Barbosa MA, Goncalves R, Comparison of an anti-inflammatory drug delivery system versus MSC therapy to control inflammation in a pro-inflammatory intervertebral disc organ culture system, 9th German Spine Conference, 11-13 December 2014, Leipzig, Germany. [3rd Place Award for Best Presentation]". 2014.
    10.1055/s-0037-1608375
  61. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Teixeira GQ, Boldt A, Mollenhauer JC, Wilke HJ, Ignatius A, Barbosa MA, Goncalves R, Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system, German Congress of Orthopaedics and Trauma Surgery (DKOU), 28-31 October 2014, Berlin, Germany". 2014.
  62. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira CL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Goncalves R, Treatment of a degenerative/pro-inflammatory intervertebral disc organ culture with Chitosan/Poly-y-glutamic acid nanoparticles carrying and anti-inflammatory drug, 26th European Conference on Biomaterials, 31 August - 3 September 2014, Liverpool, UK.". 2014.
  63. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira CL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Goncalves R, Ex vivo study of an anti-inflammatory drug delivery system based on Chitosan/Poly-y-glutamic acid nanoparticles to control inflammation in intervertebral disc organ cultures, Meeting of the German Society for Biomaterials (DGBM), 6-8 November 2014, Dresden, Germany.". 2014.
  64. Teixeira, Graciosa Q.. "Teixeira G, Lourenco AF, Barrias CC, Goncalves R, Establishment of 3D cell cultures under dynamic conditions using a multi-compartment holder for spinner flask, 25th European Conference on Biomaterials, 8-12 September 2013, Madrid, Spain.". 2013.
Conference poster
  1. de Roy L, Piquet O, Teixeira G, Weiske MF, Mayr HO, Seidenstuecker M, Seitz AM. "de Roy L, Piquet O, Teixeira G, Weiske MF, Mayr HO, Seidenstuecker M, Seitz AM, The in-vitro test conditions influence the biomechanical properties of degenerated lateral menisci - a comparative study at two laboratories. Orthopaedic Research Society (ORS) 2022 Annual Meeting, 4-8 February 2022, Tampa, Florida, USA.". 2022.
  2. Jansen JU, Teixeira GQ, Vernengo A, Grad S, Neidlinger-Wilke C, Wilke HJ. "Jansen JU, Teixeira GQ, Vernengo A, Grad S, Neidlinger-Wilke C, Wilke HJ, In-vitro Simulation der Bandscheibendegeneration - Chondroitinase oder Papain simulieren unterschiedliche Pathologien. 16th German Spine Conference, 9-11 December 2021, Münster, Germany: Eur Spine J; 2021. p. 3361". 2021.
  3. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Höpfner Y, Nothelfer J, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSC secretome decreases pro-inflammatory response in loaded AF organ cultures. TERMIS 6th World Congress, 15-19 November 2021, Virtual". 2021.
  4. Teixeira, Graciosa Q.. "Cui S, Li W, Teixeira G, Neidlinger-Wilke C, Wilke HJ, Richards RG; Alini M, Grad S, Li Z, Neoepitope peptides biomarker for different types of intervertebral disc degeneration. Orthopaedic Research Society (ORS) 2021 Annual Meeting, 12-16 February 2021, Virtual.". 2021.
  5. Teixeira, Graciosa Q.. "Teixeira GQ, Ekkerlein A, Goncalves RM, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSC secretome treatment of loaded annulus fibrosus organ cultures decreases the inflammatory response. Orthopaedic Research Society (ORS) 2021 Annual Meeting, 12-16 February 2021, Virtual. [Best Poster Award]". 2021.
  6. Teixeira, Graciosa Q.. "Jansen JU, Teixeira G, Vernengo A, Grad S, Neidlinger-Wilke C, Wilke HJ, Tissue Digestion with Chondroitinase or Papain – a suitable method to create degenerated discs for in vitro experiments? ISSLS Annual Meeting, 1-4 June 2021, Virtual, accepted.". 2021.
  7. Teixeira, Graciosa Q.. "Yong Z, Teixeira GQ, Kuhn A, Ruf M, Mauer UM, Ignatius A, Brenner R, Neidlinger-Wilke C, IL-1ß and Cathepsin-D modulate cellular terminal complement complex formation in human disc tissue. Orthopaedic Research Society (ORS) 2020 Annual Meeting, 8-11 February 2020, Phoenix, Arizona, USA". 2020.
  8. Teixeira, Graciosa Q.. "Ferreira J, Teixeira GQ, Pereira CL, Ribeiro-Machado C, Caldeira J, Barbosa MA, Lamghari M, Almeida-Porada G, Goncalves RM, Dissecting the key players in a mesenchymal stem/stromal cell-based immunomodulatory therapy for intervertebral disc degeneration. EUROSPINE Virtual Meeting, 6-9 October 2020.". 2020.
  9. Teixeira, Graciosa Q.. "Wilke HJ, Zengerle L, Zöllner L, Teixeira GQ, Neidlinger-Wilke C. Does the intradiscal pressure really correlate with the GAG content of the disc? 15th German Spine Conference, 9-11 December 2020, Virtual: Eur Spine J; 2020. p. 2916-7.". 2020.
  10. "Does the terminal complement complex play a role in disc degeneration?". 2019.
    10.3205/19DKOU336
  11. Teixeira, Graciosa Q.. "Goncalves RM, Teixeira GQ, Yong Z, Saggese T, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSCs secretome decreases matrix degrading activity of annulus fibrosus cells under mechanical loading and an inflammatory environment. ISSLS Annual Meeting, 3-7 June 2019, Kyoto, Japan". 2019.
  12. Teixeira, Graciosa Q.. "Teixeira GQ, Yong Z, Kuhn A, Ruf M, Nerlich A, Ignatius A, Brenner R, Neidlinger-Wilke C, Does the terminal complement complex play a role in disc degeneration? DKOU, 22-25 October 2019, Berlin, Germany". 2019.
  13. Teixeira, Graciosa Q.. "Goncalves RM, Teixeira GQ, Yong Z, Saggese T, Ferreira JR, Ignatius A, Wilke HJ, Neidlinger-Wilke C, MSCs secretome decreases matrix degrading activity of annulus fibrosus cells under mechanical and pro-inflammatory stimuli. 14th German Spine Conference, 28-30 November 2019, Munich, Germany". 2019.
  14. Teixeira, Graciosa Q.. "Pereira CL, Cunha C, Teixeira GQ, D’Este M, Eglin D, Alini M, Grad S, Barbosa MA, Gonc¸alves RM, SDF-1 mediated-mesenchymal stem cells recruitment: a new perspective for intervertebral disc degeneration treatment, eCM XVIII: Cartilage & Disc: Repair and Regeneration, 25-28 June 2018, Davos, Switzerland". 2018.
  15. Teixeira, Graciosa Q.. "Saggese T, Teixeira GQ, Moll L, Wade K, Weigl A, Goncalves RM, Ignatius A, Wilke HJ, Neidlinger-Wilke C, Combined mechanical stress and inflammatory environment contribute to weakening of the anulus fibrosus: insights from a bovine AF organ culture model, eCM XVIII: Cartilage & Disc: Repair and Regeneration, 25-28 June 2018, Davos, Switzerland". 2018.
  16. Teixeira, Graciosa Q.. "Teixeira GQ, Saggese T, Yong Z, Kuhn A, Goncalves RM, Ruf M, Mauer UM, Ignatius A, Brenner R, Neidlinger- Wilke C, Regional differences in terminal complement complex (TCC) deposition suggest a correlation with degenerative changes of intervertebral disc endplates, 11th International Conference on Complement Therapeutics, 23-28 June 2018, Chania, Greece". 2018.
  17. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Barbosa MA, Gonc¸alves RM, Towards the use of Mesenchymal Stem/Stromal Cells secretome to modulate the inflammatory response in intervertebral disc degeneration, CESB, 21-24 May 2017, Porto, Portugal". 2017.
  18. Teixeira, Graciosa Q.. "Pereira CL, Teixeira GQ, Caldeira J, Ribeiro-Machado C, Aguiar P, D’Este M, Eglin D, Alini M, Grad S, Barbosa MA, Goncalves RM, Hyaluronan based-hydrogel to guide cells navigation in intervertebral disc towards regeneration, CESB, 21-24 May 2017, Porto, Portugal". 2017.
  19. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Ribeiro-Machado C, Leite Pereira C, Barbosa MA, Gonc¸alves RM, Towards the use of Mesenchymal Stem/Stromal Cells secretome to modulate the inflammatory response in intervertebral disc degeneration, 6th Advanced Summer School: The Research/Clinic Interface at the Spine, 19-22 June 2017, Porto, Portugal. [Best Poster Award]". 2017.
  20. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Ribeiro-Machado C, Leite Pereira C, Barbosa MA, Goncalves RM, Towards the use of Mesenchymal Stem/Stromal Cells secretome to modulate the inflammatory response in intervertebral disc degeneration, 2nd Symposium on Immunomodulation in Cancer & Regeneration, 23 June 2017, Porto, Portugal". 2017.
  21. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Barbosa MA, Gonc¸alves R, Dissecting mesenchymal stem/stromal cells secretome to modulate the inflammatory response of degenerated intervertebral disc, TERMIS-EU Meeting, 26-30 June 2017, Davos, Switzerland". 2017.
  22. Teixeira, Graciosa Q.. "Cunha C, Teixeira GQ, Pereira CL, Eglin D, Grad S, Gonc¸alves RM, Barbosa MA, Rat intervertebral disc degeneration and herniation model for local biomaterial delivery. 28th European Conference on Biomaterials, 4-8 September 2017, Athens, Greece". 2017.
  23. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Barbosa MA, Gonc¸alves RM, Influence of Mesenchymal Stem/Stromal Cells preconditioning on the immunomodulatory capacity of their secretome, 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 12-14 October 2017, Covilha~, Portugal". 2017.
  24. Teixeira, Graciosa Q.. "Ferreira JR, Teixeira GQ, Gonc¸alves RM, The role of Mesenchymal stem/stromal cells secretome in the degenerated IVD, 7th Symposium in Bioengineering, NEB/FEUP-ICBAS, 22-23 April 2016, Porto, Portugal. [Best Poster Award]". 2016.
  25. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Nagl I, Teixeira GQ, Kletsas D, Wilke HJ, Ignatius A, Influence of pro-inflammatory stimulation by IL-1ß on chondrogenic differentiation of human mesenchymal stem cells (MSCs) versus adipose - derived stem cells (ASCs), ISSLS/SpineWeek, 16-20 May 2016, Singapore.". 2016.
  26. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Teixeira GQ, Rapp A, Kletsas D, Ignatius A, Chondrogenic differentiation of bone marrow derived stem cells (MSCs) versus adipose derived stem cells (ASCs) at pro-inflammatory conditions, eCM XVII: Stem Cells, Bone Fixation, Repair & Regeneration, 20-23 June 2016, Davos, Switzerland". 2016.
  27. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Nagl I, Teixeira GQ, Kletsas D, Ignatius A, Chondrogenic differentiation of bone marrow derived stem cells (MSCs) versus adipose derived stem cells (ASCs) at pro-inflammatory conditions. German Congress of Orthopaedics and Trauma Surgery (DKOU), 25-28 October 2016, Berlin, Germany". 2016.
  28. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira CL, Mollenhauer J, Wilke HJ, Barbosa MA, Ignatius A, Gonc¸alves R, Neidlinger-Wilke C, Comparison of an anti-inflammatory drug delivery system versus MSC therapy to control inflammation in a pro- inflammatory intervertebral disc organ culture system, ISSLS Annual Meeting, 8-12 June 2015, San Francisco, CA, USA". 2015.
  29. Teixeira, Graciosa Q.. "Teixeira GQ, Pereira CL, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Gonc¸alves RM, Intradiscal application of anti-inflammatory nanoparticles control inflammation while remodel extracellular matrix of degenerated intervertebral disc, Advanced Summer School: Interrogations at the Biointerface - the Nano/Medicine Interface, 29 June-3 July 2015, Porto, Portugal". 2015.
  30. Teixeira, Graciosa Q.. "Teixeira GQ, Goncalves R, Boldt A, Jahn C, Mollenhauer J, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system, World Forum for Spine Research (WFSR), 15-17 May 2014, Xi’ an, China". 2014.
  31. Teixeira, Graciosa Q.. "Teixeira GQ, Goncalves R, Boldt A, Jahn C, Mollenhauer J, Wilke HJ, Barbosa MA, Ignatius A, Neidlinger-Wilke C, Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system, ISSLS Annual Meeting, 3-7 June 2014, Seoul, Korea". 2014.
  32. Teixeira, Graciosa Q.. "Neidlinger-Wilke C, Boldt A, Teixeira GPQ, Jahn C, Mollenhauer J, Wilke HJ, Ignatius A, Barbosa M, Goncalves R, Constrained intervertebral disc organ culture for simulation of cell therapy approaches, EUROSPINE, 2-4 October 2013, Liverpool, UK". 2013.
  33. Teixeira, Graciosa Q.. "Teixeira GQ, Gonc¸alves R, Boldt A, Jahn C, Mollenhauer J, Wilke HJ, Ignatius A, Barbosa MA, Neidlinger-Wilke C, Simulation of degenerative and pro-inflammatory conditions for testing of cell therapy approaches in a disc organ culture system, 8th German Spine Conference, 5-7 December 2013, Frankfurt, Germany. [Special Poster Communication - 3rd Place Award for Best Poster]". 2013.
Journal article
  1. Cui S; Li W; Graciosa Q Teixeira; Neidlinger-Wilke C; Wilke HJ; Haglund L; Ouyang H; et al. "Neoepitope fragments as biomarkers for different phenotypes of intervertebral disc degeneration". JOR SPINE (2022): http://dx.doi.org/10.1002/jsp2.1215.
    10.1002/jsp2.1215
  2. Gonçalves, Raquel M.; Saggese, Taryn; Yong, Zhiyao; Ferreira, Joana R.; Ignatius, Anita; Wilke, Hans-Joachim; Neidlinger-Wilke, Cornelia; Teixeira, Graciosa Q.. "Interleukin-1ß More Than Mechanical Loading Induces a Degenerative Phenotype in Human Annulus Fibrosus Cells, Partially Impaired by Anti-Proteolytic Activity of Mesenchymal Stem Cell Secretome". Frontiers in Bioengineering and Biotechnology 9 (2022): http://dx.doi.org/10.3389/fbioe.2021.802789.
    10.3389/fbioe.2021.802789
  3. Castro, A. L.; Ribeiro-Machado, C.; Oliveira, C. M.; Teixeira, G. Q.; Neidlinger-Wilke, C.; Pereira, P.; Vaz, R.; Barbosa, M. A.; Gonçalves, R. M.. "Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation". Arthritis Research & Therapy 24 1 (2022): http://dx.doi.org/10.1186/s13075-021-02690-w.
  4. Graciosa Q. Teixeira; Zhiyao Yong; Amelie Kuhn; Jana Riegger; Raquel M. Goncalves; Michael Ruf; Uwe M. Mauer; et al. "Interleukin-1ß and cathepsin D modulate formation of the terminal complement complex in cultured human disc tissue". European Spine Journal 30 8 (2021): 2247-2256. https://doi.org/10.1007/s00586-021-06901-5.
    10.1007/s00586-021-06901-5
  5. Ioannis Vasilikos; Demetrios G. Vavvas; Graciosa Q. Teixeira; Andreas Seitz; Julia Nothelfer; Julian Haas; Hans-Joachim Wilke; et al. "Can UVA-light-activated riboflavin-induced collagen crosslinking be transferred from ophthalmology to spine surgery? A feasibility study on bovine intervertebral disc". PLOS ONE (2021): https://doi.org/10.1371/journal.pone.0252672.
    10.1371/journal.pone.0252672
  6. Graciosa Q. Teixeira; Zhiyao Yong; Raquel M. Goncalves; Amelie Kuhn; Jana Riegger; Helena Brisby; Helena Barreto Henriksson; et al. "Terminal complement complex formation is associated with intervertebral disc degeneration". European Spine Journal (2021): https://doi.org/10.1007/s00586-020-06592-4.
    10.1007/s00586-020-06592-4
  7. Ferreira, Joana R.; Teixeira, Graciosa Q.; NETO, ESTRELA; Ribeiro-Machado, Cláudia; Silva, Andreia; Caldeira, Joana; Leite Pereira, Catarina; et al. "IL-1ß-pre-conditioned mesenchymal stem/stromal Cells’ secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc". Our Cell Mater (2021):
    Open access • In press
  8. Neidlinger-Wilke, Cornelia; Ekkerlein, Andreas; Goncalves, Raquel M.; Ferreira, Joana R.; Ignatius, Anita; Wilke, Hans-Joachim; Teixeira, Graciosa Q.; et al. "Mesenchymal stem cell secretome decreases inflammatory response in annulus fibrosus organ cultures". Our Cell Mater 42 (2021): 1-19. http://dx.doi.org/10.22203/ecm.v042a01.
    Open access • Under revision • 10.22203/ecm.v042a01
  9. Teixeira, Graciosa Q.. "Infrared attenuated total reflection spectroscopic surface analysis of bovine-tail intervertebral discs after UV-light-activated riboflavin-induced collagen cross-linking.". Journal of biophotonics (2020): https://doi.org/10.1002/jbio.202000110.
    10.1002/jbio.202000110
  10. Teixeira, José H.; Pereira, Catarina Leite; Almeida, Maria Inês; Teixeira, Graciosa Q.; Gonçalves, Raquel M.; Barbosa, Mário A.; Santos, Susana G.. "Articular Repair/Regeneration in Healthy and Inflammatory Conditions: From Advanced In Vitro to In Vivo Models". Advanced Functional Materials (2020): 1909523. http://dx.doi.org/10.1002/adfm.201909523.
    10.1002/adfm.201909523
  11. Cunha, Carla; Teixeira, Graciosa Q.; Ribeiro-Machado, Cláudia; L. Pereira, Catarina; Ferreira, Joana R.; Molinos, Maria; G. Santos, Susana; Barbosa, Mário A.; M. Goncalves, Raquel. "Modulation of the In Vivo Inflammatory Response by Pro- Versus Anti-Inflammatory Intervertebral Disc Treatments". International Journal of Molecular Sciences 21 5 (2020): 1730. http://dx.doi.org/10.3390/ijms21051730.
    10.3390/ijms21051730
  12. Saggese, Taryn; Teixeira, Graciosa Q.; Wade, Kelly; Moll, Lydia; Ignatius, Anita; Wilke, Hans-Joachim; Goncalves, Raquel M.; Neidlinger-Wilke, Cornelia. "GEORG SCHMORL PRIZE OF THE GERMAN SPINE SOCIETY (DWG) 2018: combined inflammatory and mechanical stress weakens the annulus fibrosus: evidences from a loaded bovine AF organ culture". European Spine Journal 28 5 (2019): 922-933. http://dx.doi.org/10.1007/s00586-019-05901-w.
    10.1007/s00586-019-05901-w
  13. Ferreira, Joana R.; Teixeira, Graciosa Q.; Santos, Susana G.; Barbosa, Mário A.; Almeida-Porada, Graça; Gonçalves, Raquel M.. "Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.02837.
    10.3389/fimmu.2018.02837
  14. Leite Pereira, Catarina; Quelhas Teixeira, Graciosa; Rita Ferreira, Joana; D'Este, Matteo; Eglin, David; Alini, Maulo; Grad, Sibylle; Barbosa, Mário Adolfo; Gonçalves, Raquel Madeira. "Stromal Cell Derived Factor-1-Mediated Migration of Mesenchymal Stem Cells Enhances Collagen Type II Expression in Intervertebral Disc". Tissue Engineering Part A 24 23-24 (2018): 1818-1830. http://dx.doi.org/10.1089/ten.tea.2018.0131.
    10.1089/ten.tea.2018.0131
  15. Mödinger, Yvonne; Teixeira, Graciosa Q.; Neidlinger-Wilke, Cornelia; Ignatius, Anita. "Role of the Complement System in the Response to Orthopedic Biomaterials". International Journal of Molecular Sciences 19 11 (2018): 3367. http://dx.doi.org/10.3390/ijms19113367.
    10.3390/ijms19113367
  16. Teixeira, G.Q.; Pereira, C.L.; Ferreira, J.R.; Maia, A.F.; Gomez-Lazaro, M.; Barbosa, M.A.; Neidlinger-Wilke, C.; et al. "Immunomodulation of Human Mesenchymal Stem/Stromal Cells in Intervertebral Disc Degeneration". Spine 43 12 (2018): E673-E682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048118371&partnerID=MN8TOARS.
    10.1097/BRS.0000000000002494
  17. Castro, Flávia; Pinto, Marta L.; Silva, Andreia M.; Pereira, Catarina L.; Teixeira, Graciosa Q.; Gomez-Lazaro, Maria; Santos, Susana G.; et al. "Pro-inflammatory chitosan/poly(y-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity". Acta Biomaterialia 63 (2017): 96-109. http://dx.doi.org/10.1016/j.actbio.2017.09.016.
    10.1016/j.actbio.2017.09.016
  18. Cunha C; Almeida CR; Almeida MI; Silva AM; Molinos M; Lamas S; Pereira CL; et al. "Systemic Delivery of Bone Marrow Mesenchymal Stem Cells for In Situ Intervertebral Disc Regeneration.". (2017): http://europepmc.org/abstract/med/28297581.
    10.5966/sctm.2016-0033
  19. Antunes, Joana C.; Pereira, Catarina Leite; Teixeira, Graciosa Q.; Silva, Ricardo V.; Caldeira, Joana; Grad, Sibylle; Gonçalves, Raquel M.; Barbosa, Mário A.. "Poly(y-glutamic acid) and poly(y-glutamic acid)-based nanocomplexes enhance type II collagen production in intervertebral disc". Journal of Materials Science: Materials in Medicine 28 1 (2016): http://dx.doi.org/10.1007/s10856-016-5787-1.
    10.1007/s10856-016-5787-1
  20. Pereira, Catarina Leite; Teixeira, Graciosa Q.; Ribeiro-Machado, Cláudia; Caldeira, Joana; Costa, Madalena; Figueiredo, Francisco; Fernandes, Rui; et al. "Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep33836.
    10.1038/srep33836
  21. Teixeira, Graciosa Q.; Leite Pereira, Catarina; Castro, Flávia; Ferreira, Joana R.; Gomez-Lazaro, Maria; Aguiar, Paulo; Barbosa, Mário A.; Neidlinger-Wilke, Cornelia; Goncalves, Raquel M.. "Anti-inflammatory Chitosan/Poly-y-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc". Acta Biomaterialia 42 (2016): 168-179. http://dx.doi.org/10.1016/j.actbio.2016.06.013.
    10.1016/j.actbio.2016.06.013
  22. Teixeira, Graciosa Q.; Boldt, Antje; Nagl, Ines; Pereira, Catarina Leite; Benz, Karin; Wilke, Hans-Joachim; Ignatius, Anita; et al. "A Degenerative/Proinflammatory Intervertebral Disc Organ Culture: An Ex Vivo Model for Anti-inflammatory Drug and Cell Therapy". Tissue Engineering Part C: Methods 22 1 (2016): 8-19. http://dx.doi.org/10.1089/ten.tec.2015.0195.
    10.1089/ten.tec.2015.0195
  23. Teixeira, Graciosa Q.; Barrias, Cristina C.; Lourenço, Ana H.; Gonçalves, Raquel M.. "A Multicompartment Holder for Spinner Flasks Improves Expansion and Osteogenic Differentiation of Mesenchymal Stem Cells in Three-Dimensional Scaffolds". Tissue Engineering Part C: Methods 20 12 (2014): 984-993. http://dx.doi.org/10.1089/ten.tec.2014.0067.
    10.1089/ten.tec.2014.0067
Thesis / Dissertation
  1. Graciosa Q Teixeira. "Modulation of inflammatory response associated within intervertebral disc degeneration". PhD, 2017. https://hdl.handle.net/10216/105612.
  2. Graciosa Q Teixeira. "Establishment of 3D cell cultures under dynamic conditions using a multi-compartment holder for spinner flask". Master, 2012. http://hdl.handle.net/10400.14/11370.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021 Potential of MSC secretome to modulate degenerative changes in a loaded annulus fibrosus organ culture model ISSLS Annual Meeting
ISSLS (Virtual)
2020 Can disc degeneration-associated factors activate terminal complement complex (TCC) formation? 15th German Spine Conference
German Spine Society (Virtual)
2020 MSC secretome decreases pro-inflammatory response in loaded AF organ cultures 15th German Spine Conference
German Spine Society (Virtual)
2020 Modulation of the terminal complement complex formation in human disc tissue cultures EUROSPINE Virtual Meeting
EUROSPINE Society (Virtual)
2019 Terminal complement complex formation in degenerated discs correlates with degree of degeneration 14th German Spine Conference
German Spine Society (Munich, Germany)
2019 Terminal complement complex (TCC): a possible target for in intervertebral disc degeneration therapeutics EUROSPINE Annual Meeting
EUROSPINE (Helsinki, Finland)
2019 Is the terminal complement complex a possible target for therapeutic innervation in intervertebral disc degeneration? ISSLS Annual Meeting
International Society for the Study of the Lumbar Spine (ISSLS) (Kyoto, Japan)
2019 Is the terminal complement complex a target for intervertebral disc degeneration therapeutics? TERMIS-EU Chapter Conference
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Rhodes, Greece)
2019 Does the terminal complement complex play a role in disc degeneration? BioSpine 7th International Congress on Biotechnologies for Spinal Surgery
(Rome, Italy)
2019 MSCs secretome decreases matrix degrading activity of annulus fibrosus cells under mechanical loading and inflammatory environment BioSpine 7th International Congress on Biotechnologies for Spinal Surgery
(Rome, Italy)
2018 Inflammatory stimulation and mechanical loading lead to a weakening of the trans-lamellar bridging network of the anulus fibrosus 8th World Congress of Biomechanics
(Dublin, Ireland)
2017 Mesenchymal stem/stromal cells immunomodulatory role through a paracrine mechanism in degenerated IVD TERMIS-EU Chapter Meeting
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Davos, Switzerland)
2017 Mesenchymal stem/stromal cells immunomodulatory role in degenerated IVD 6th Advanced Summer School: The Research/Clinic Interface at the Spine
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2017 Poly(y-glutamic acid)-based nanoparticles locally control inflammation and promote extracellular matrix remodeling in Intervertebral disc 6th China-Europe Symposium on Biomaterials in Regenerative Medicine (CESB)
Universidade do Porto Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2016 Local treatment of inflammation in degenerated intervertebral disc using poly(y-glutamic acid)-based nanocomplexes promotes extracellular matrix remodeling TERMIS-EU Chapter Meeting
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Uppsala, Sweden)
2015 Intradiscal application of anti-inflammatory nanoparticles control inflammation while remodel extracellular matrix of degenerated intervertebral disc 1st Symposium on Immunomodulation in Cancer & Regeneration
Universidade do Porto Instituto Nacional de Engenharia Biomédica (Porto, Portugal)
2015 Local treatment of inflammation and degeneration of intervertebral disc: ex vivo study of anti-inflammatory drug delivery system based on Chitosan/Poly-(y-Glutamic acid) nanoparticles BioSpine 5th International Congress Biotechnologies of Spinal Surgery
(Berlin, Germany)
2015 Does mesenchymal stem cell therapy have the potential to control inflammation in a pro-inflammatory intervertebral disc organ culture system? BioSpine 5th International Congress Biotechnologies of Spinal Surgery
(Berlin, Germany)
2014 Ex vivo study of an anti-inflammatory drug delivery system based on Chitosan/Poly-y-glutamic acid nanoparticles to control inflammation in intervertebral disc organ cultures Meeting of the German Society for Biomaterials (DGBM)
German Society for Biomaterials (DGBM) (Dresden, Germany)
2014 Treatment of a degenerative/pro-inflammatory intervertebral disc organ culture with Chitosan/Poly-y-glutamic acid nanoparticles carrying and anti-inflammatory drug 26th European Conference on Biomaterials
European Society for Biomaterials (ESB) (Liverpool, United Kingdom)
2013 Establishment of 3D cell cultures under dynamic conditions using a multi-compartment holder for spinner flask 25th European Conference on Biomaterials
European Society for Biomaterials (ESB) (Madrid, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2019/04 - Current Investigation of immune modulating approaches in an annulus fibrosus organ culture model
Co-supervisor
 Human Medicine (PhD)
Universität Ulm Medizinische Fakultät, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2017/10 - 2021/01/28 Role of the terminal complement complex in intervertebral disc degeneration
Co-supervisor
 Human Medicine (PhD)
Universität Ulm Medizinische Fakultät, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2020/04 - 2020/11 Does complement deficiency influence intervertebral disc phenotype? Insights from C6 and CD59 deficient mice organ culture investigations
Co-supervisor
 Biology - Bachelor of Science (BSc) (Degree)
Universität Ulm Fachbereich Biologie, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2019/10 - 2020/06 Collagen crosslink by Riboflavin and UVA light treatment on bovine intervertebral disc
Co-supervisor
 Industrial Biotechnology - Master of Science (Master)
Hochschule Biberach, Germany

Universität Ulm, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2019/07 - 2019/10 Characterization of intervertebral disc changes in complement deficient mouse strains
Co-supervisor
 Molecular Medicine - Bachelor of Science (BSc) (Degree)
Universität Ulm Medizinische Fakultät, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany
2016 - 2016 Towards the use of mesenchymal stem cells secretome to treat intervertebral disc degeneration
Co-supervisor
 Mestrado em Engenharia Biomédica (Master)
Universidade do Porto Faculdade de Engenharia, Portugal

Association member

Society Organization name Role
2020 - Current European Society of Biomechanics
2020 - Current International Society for the Study of the Lumbar Spine (ISSLS)
2019 - Current Orthopaedic Research Society (ORS) and ORS Spine Section
2018 - Current Tissue Engineering and Regenerative Medicine International Society (TERMIS)
2018 - Current MusculoSkeletal Interdisciplinary Translational Young Researchers (MuSkITYR)
2018 - 2019 European Society for Biomaterials

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Trauma Research and Regenerative Medicine Course Topics: Bone - homeostasis and disease; Bone mechanotransduction; Fracture healing; Problem-based learning session Molecular Medicine Master's Program (Master) Universität Ulm Medizinische Fakultät, Germany
2020 - Current Biomaterials; Tissue Engineering Medical Engineering Bachelor's Program (Bachelor) Technische Hochschule Ulm, Germany
2017 - 2017 Laboratory course at Advanced Summer School: The Research/Clinic Interface at the Spine (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015 - 2015 Laboratory course at Advanced Summer School: Interrogations at the Biointerface - the Nano/Medicine Interface (Outros) Instituto Nacional de Engenharia Biomédica, Portugal
2014 - 2014 Lab session at Cell Biomechanics and Tissue Engineering Course Molecular Medicine - Master of Science (MSc) (Master) Universität Ulm Medizinische Fakultät, Germany

Universitätsklinikum Ulm Institut für Unfallchirurgische Forschung und Biomechanik, Germany

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current European Cells & Materials (1473-2262)
2019 - Current Osteoarthritis and Cartilage (1522-9653) Elsevier
2018 - Current European Spine Journal (1432-0932) Springer-Verlag

Mentoring / Tutoring

Topic Student name
2019/10 - 2020/03 Investigation of protein production after MSC-based treatment of an annulus fibrosus organ culture model Yana Höpfner
2020/01/13 - 2020/02/12 Collagen cross-link by Riboflavin and UVA light treatment on bovine intervertebral discs Aline Grempels
2019/03 - 2019/06 Morphological characterization of discs from complement-deficient mice Julian Ostertag
2018/04 - 2018/10 Testing of mesenchymal stem cell differentiation in different materials Anastasia Raiber
2013 - 2014 Establishment of a pro-inflammatory/degenerative organ culture model Ines Nagl
Distinctions

Award

2021 Best Poster Award, Orthopaedic Research Society Spine Section
Orthopaedic Research Society, United States
2020 Traveling Fellowship
Universität Ulm Medizinische Fakultät, Germany
2019 ISSLS Young Investigator Travel Grant
2019 Hertha Nathorff Traveling Fellowship
Universität Ulm Medizinische Fakultät, Germany
2019 Best Paper Award, International Society for the Study of the Lumbar Spine (ISSLS)
2019 EUROSPINE Travel Grant
2019 Best Abstract Award, MuskITYR Symposium
2018 Julia Polak European Doctoral Award, European Society for Biomaterials
2018 Best Research Article Award (3rd place), TERMIS SYIS and Mary Ann Liebert, Inc., publishers
2018 Georg Schmorl Prize, German Spine Society
2014 Best Presentation Award (3rd place), German Spine Conference
2013 Best Poster Award (3rd place), German Spine Conference
2009 Award of Merit for academic distinction
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2008 Merit Scholarship for academic distinction
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior, Portugal
2008 Award of Merit for academic distinction
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal

Other distinction

2020 Cover article of Journal of Biophotonics
2016 Cover article of Tissue Eng Part C Methods
2014 Cover article of Tissue Eng Part C Methods
2007 Rotary Medal for educational distinction, Rotary Club, São Mamede de Infesta, Portugal