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Mariana holds a Bachelor’s degree in Biological Sciences (UNIFESP, Brazil, 2010-2014), a Master’s in Structural and Functional Biology (UNIFESP, 2014-2017), and a PhD in Structural and Functional Biology (UNIFESP, 2017-2022), with a training period at the Houston Methodist Research Institute (Texas, USA). Her doctoral research focused on the action of bioactive compounds in thyroid cancer, particularly in anaplastic and papillary carcinomas, using 3D and monolayer culture models. Her research also includes investigating the genetic causes of familial non-medullary thyroid cancer through whole-exome sequencing, as well as studying the role of microRNAs in head and neck squamous cell carcinoma as potential diagnostic and prognostic markers. Currently, Mariana is a Research Technician for the CInTech project at the University of Coimbra, where she is part of the functional assay team. In addition to her research, she has gained teaching experience in genetics, including cancer genetics, and has contributed to science communication initiatives. Scholarships from CAPES and FAPESP have supported her professional journey, and she continues to build on her expertise in cancer molecular biology and the development of therapeutic strategies for thyroid cancer and other malignancies.
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Identification

Personal identification

Full name
Mariana Teixeira Rodrigues

Citation names

  • RODRIGUES, MARIANA T
  • RODRIGUES, M. T.
  • Rodrigues, M
  • RODRIGUES, MARIANA TEIXEIRA

Author identifiers

Ciência ID
161D-7DBA-D3B9
ORCID iD
0000-0002-3489-233X
Google Scholar ID
https://scholar.google.com/citations?user=l8oMN0wAAAAJ&hl=pt-PT&oi=ao
LattesiD
http://lattes.cnpq.br/8949906421066457
Scopus Author Id
57217593729

Email addresses

  • mtrodrigues@uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Genetics and Heredity

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
French Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2024/10 - 2024/11
Concluded
 Webinar Series: Fundamentals of the Publicase Method for Writing Scientific Papers. (Outros)
Publicase International, Portugal
2024/07/02 - 2024/07/02
Concluded
 Como elaborar um plano de gestão de dados de investigação (Outros)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/04 - 2022/07
Concluded
 Social Media Management - PDJ-GRS09 (Curso de Especialização Tecnológica)
Instituto do Emprego e Formação Profissional, Portugal
2017 - 2022
Concluded
 Structural and Functional Biology (Doctorat)
Universidade Federal de São Paulo, Brazil
"Action of bioactive compounds on thyroid cancer" (THESIS/DISSERTATION)
2021/04 - 2021/07
Concluded
 Laboratory Safety: Environmental and Occupational Aspects (Curso de doutoramento (conclusão de unidades curriculares))
Universidade Federal de São Paulo, Brazil
2021/03 - 2021/07
Concluded
 Ethics in Scientic Research (Curso de doutoramento (conclusão de unidades curriculares))
Universidade Federal de São Paulo, Brazil
2019/07/15 - 2019/08/20
Concluded
 Non-coding RNAs in Cancer (Curso de doutoramento (conclusão de unidades curriculares))
Universidade Federal de São Paulo, Brazil
2014 - 2017
Concluded
 Structural and Functional Biology (Master)
Universidade Federal de São Paulo, Brazil
"Research on genetic causes of familial non-medullary thyroid cancer" (THESIS/DISSERTATION)
 19
2016/01/18 - 2016/01/22
Concluded
 Summer Course - Bioinformatics (Outros)
Universidade de São Paulo, Brazil
2015/03 - 2015/06
Concluded
 Statistical Analysis (Outros)
Universidade Federal de São Paulo, Brazil
2010 - 2014
Concluded
 Biological Sciences (Licence)
Universidade Federal de São Paulo, Brazil
"EVALUATION OF miRNAs miR-200a, miR-200c, miR-203, AND miR-205 EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA SAMPLES" (THESIS/DISSERTATION)
Affiliation

Other Careers

Category
Host institution 		Employer
2024/02/26 - Current Técnico Superior (Técnico Superior) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2022/05/30 - 2023/08/02 Scientific Translator Journal of Visualized Experiments (JoVE), United States
2021/12/29 - 2022/04/25 Técnica Covid SYNLAB , Portugal
2017 - 2022 PhD Candidate Universidade Federal de São Paulo, Brazil
2019/10/01 - 2020/01/02 Visiting Graduate Research Fellow Houston Methodist, United States
Houston Methodist Academic Institute, United States
2014 - 2017 MSc Candidate Universidade Federal de São Paulo, Brazil
2011 - 2014 Aluna de Iniciação Científica Universidade Federal de São Paulo, Brazil
Projects

Grant

Designation Funders
2017 - 2021 Action of bioactive compounds on thyroid cancer
88882.430359/2019-01
PhD Student Fellow
Universidade Federal de São Paulo, Brazil
 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Concluded
2014 - 2017 Research on genetic causes of familial non-medullary thyroid cancer
.
Master Student Fellow
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Concluded
2012 - 2014 EVALUATION OF miRNAs miR-200a, miR-200c, miR-203, AND miR-205 EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA SAMPLES
12/21105-2
Scientific Initiation Fellow
Universidade Federal de São Paulo - Campus Diadema, Brazil

Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brasil, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2011/06 - 2011/10 The role of insulin-like growth factor on heat stress-induced apoptosis in oocytes at the germinal vesicle stage.
11/09587-9
Scientific Initiation Fellow
Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded

Contract

Designation Funders
2024/02/26 - Current CInTech: Technological Hub for Innovation, Translation, and Industrialization of Complex Injectable Drugs
C644865576-00000005
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Outputs

Publications

Conference abstract
  1. Catarina Oliveira Miranda; Perfeito, Rita; Sónia P. Duarte; Paulo, Cristiana; RODRIGUES, M. T.; Gaspar, Laetitia S; Dina Maria da Silva Rodrigues Pereira; et al. "Comparative analysis of transfection kits for linear, self-amplifying, and circular RNA". Paper presented in 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Published
  2. Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; Dina Maria da Silva Rodrigues Pereira; De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; Rita Perfeito; et al. "Maximizing Yield and Functionality in saRNA Production: A Comparative Study of Commercial Kits and In Vitro Transcription Conditions". Paper presented in 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Published
  3. De Luca, Pasqualino; Sara Isabel Monteiro Lopes; Dina Maria da Silva Rodrigues Pereira; Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; Pedro Ricardo Lucas Perdigão; Alexandra de Almeida e Melo; et al. "Optimizing in vitro transcription methods for enhanced mRNA-based therapeutics". Paper presented in 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Published
  4. Dina Maria da Silva Rodrigues Pereira; Ana Sofia de Castro Valdeira; Francisca Santos Silva; Gaspar, Laetitia S; De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; et al. "A comparative analysis of commercial kits for enhanced circular mRNA production: yield, profile, and in vitro assessment". Paper presented in 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Published
  5. RODRIGUES, MARIANA TEIXEIRA; Ana Paula Picaro Michelli; Rodrigo Esaki Tamura; Biana Godin; Jamille Calil-SILVEIRA; ILEANA GABRIELA SANCHEZ DE RUBIO. Corresponding author: ILEANA GABRIELA SANCHEZ DE RUBIO. "ANTINEOPLASIC EFFECTS OF SE-L-METHIONINE IN MONOLAYER AND SPHEROIDS CULTURES OF PAPILLARY AND ANAPLASTIC THYROID CANCER CELL LINES (104343)". Paper presented in XVII LATIN AMERICAN THYROID CONGRESS, 2021.
  6. RODRIGUES, M. T.; ANA PAULA PICARO MICHELLI; RODRIGO ESAKI TAMURA; BIANA GODIN; JAMILE CALIL-SILVEIRA; ILEANA GABRIELA SANCHEZ DE RUBIO. "THE ANTINEOPLASTIC ACTIVITY OF THE ALKALOID LYSICAMINE IN MONOLAYER AND SPHEROID MODELS OF PAPILLARY AND ANAPLASTIC THYROID CANCER (104344)". Paper presented in XVII LATIN AMERICAN THYROID CONGRESS, 2021.
    Published
  7. RODRIGUES, M. T.; Jamile Calil Silveira; , Ileana Gabriela Sanchez de Rubio. Corresponding author: , Ileana Gabriela Sanchez de Rubio. "ATIVIDADE CITOTÓXICA DO COMPOSTO BIOATIVO SELÊNIO-L-METIONINA EM CÂNCER DE TIREOIDE (93210)". Paper presented in XIX Encontro Brasileiro deTireoide, 2020.
    Published
  8. RODRIGUES, M. T.; Gabriela Simões Alderado; Rodrigo Esaki Tamura; Silvia Cristina Figueira Olinto; Jamile Calil Silveira; Ileana Gabriela Sanchez de Rubió. "ANTITUMOR EFFECTS OF BIOACTIVE COMPOUNDS IN THYROID CANCER (TL1210)". Paper presented in XVII Latin American Thyroid Congress, Buenos Aires, 2019.
    Published
  9. RODRIGUES, M. T.; Fernanda Christtanini Koyama; Anamaria A. Camargo; Fernanda Orpinelli Ramos Do Rego; Pedro Alexandre Favoretto Galante; Lidiane de Lima Feitoza ; Gianna Maria Griz Carvalheira; Janete Maria Cerutti; Ileana Gabriela Sanchez de Rubió. "MUTATION IN MSN GENE ASSOCIATED WITH A FAMILY WITH NON-MEDULLARY THYROID CANCER IDENTIFIED BY WHOLE EXOME SEQUENCING (TL1190)". Paper presented in XVII Latin American Thyroid Congress, Buenos Aires, 2019.
    Published
  10. RODRIGUES, M. T.; F. Koyama; A. Camargo; F.O. Rego; P. Galante; L. de Lima Feitoza; G.M. Griz Carvalheira; J.M. Cerutti; I.G. Rubio. "COSEGREGATION OF MSN VARIANT IDENTIFIED BY WHOLE-EXOME SEQUENCING IN A BRAZILIAN FAMILY SUSPECTED OF FAMILIAL NON-MEDULLARY THYROID CANCER (374)". Paper presented in 87th ANNUAL MEETING OF THE AMERICAN THYROID ASSOCIATION, Victoria, 2017.
Conference poster
  1. Sónia P. Duarte; Rita Perfeito; Catarina Sofia Oliveira Miranda; RODRIGUES, M. T.; Paulo, Cristiana; Dina Maria da Silva Rodrigues Pereira; De Luca, Pasqualino; et al. "Functional assays to optimize transfection efficiency for linear, circular and self-amplifying mRNA". Paper presented in 12th mRNA Health Conference, 2024.
  2. De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Gaspar, Laetitia S; Dina Maria da Silva Rodrigues Pereira; Bruno Filipe Pinheiro Marques; Sara Isabel Monteiro Lopes; Alexandra Melo; et al. "Maximizing mRNA vaccine production by optimizing in vitro transcription processes". Paper presented in 12th mRNA Health Conference, 2024.
  3. Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; De Luca, Pasqualino; Dina Maria da Silva Rodrigues Pereira; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; Rita Perfeito; et al. "Cost-Effective Optimization of Self-Amplifying mRNA Production: Comparative Analysis of Commercial Kits and In Vitro Transcription Conditions". Paper presented in 12th mRNA Health Conference, 2024.
  4. Dina Maria da Silva Rodrigues Pereira; Ana Sofia de Castro Valdeira; De Luca, Pasqualino; Gaspar, Laetitia S; Sara Isabel Monteiro Lopes; Pedro Ricardo Lucas Perdigão; Santos Silva, Francisca; et al. "Enhancing circular mRNA yield through in vitro transcription optimization". Paper presented in 12th mRNA Health Conference, 2024.
  5. RODRIGUES, M. T.. "IDENTIFICAÇÃO DE VARIANTES PROVAVELMENTE PATOGÊNICAS EM UMA FAMÍLIA COM SUSPEITA DE CARCINOMA NÃO MEDULAR FAMILIAL DA TIREOIDE POR MEIO DO SEQUENCIAMENTO COMPLETO DO EXOMA EXPANDIDO". Paper presented in Next Frontiers to Cure Cancer, 2018.
Journal article
  1. Mariana Teixeira Rodrigues; Ana Paula Picaro Michelli; Gustavo Felisola Caso; Paloma Ramos de Oliveira; Rodrigues-Junior, DM; Mirian Galliote Morale; Joel Machado Júnior; et al. "Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/12/1687.
    10.3390/ph16121687
  2. Tania Maria Barreto Rodrigues; Marlon Messias da Conceição Silva; Magali Maciel Freitas; Zélia Maria Costa Duarte; Vitória Sousa Frutuoso; Mariana Teixeira Rodrigues; Ileana Gabriela Sanchez Rubio. "Case Report: Functional Analysis and Neuropsychological Evaluation of Dyshormonogenetic Fetal Goiter in Siblings Caused by Novel Compound Hyterozygous TPO Gene Mutations". Frontiers in Endocrinology (2021): http://dx.doi.org/10.3389/fendo.2021.671659.
    10.3389/fendo.2021.671659
  3. Caldas, L.A.; Rodrigues, M.T.; Batista, A.N.L.; Batista, J.M.; Lago, J.H.G.; Ferreira, M.J.P.; Rubio, I.G.S.; Sartorelli, P.. "Sesquiterpene lactones from calea pinnatifida: Absolute configuration and structural requirements for antitumor activity". Molecules 25 13 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087399750&partnerID=MN8TOARS.
    10.3390/molecules25133005
  4. Erika Urbano de Lima. "Familial Nonmedullary Thyroid Carcinoma (Fnmtc): Molecular Advances with the New Sequencing Technologies". Journal of Endocrinology and Thyroid Research (2018): http://dx.doi.org/10.19080/jetr.2018.03.555618.
    10.19080/jetr.2018.03.555618
  5. Rodrigues, T.A.; Ispada, J.; Risolia, P.H.B.; Rodrigues, M.T.; Lima, R.S.; Assumpção, M.E.O.A.; Visintin, J.A.; Paula-Lopes, F.F.. "Thermoprotective effect of insulin-like growth factor 1 on in vitro matured bovine oocyte exposed to heat shock". Theriogenology 86 8 (2016): 2028-2039. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990964727&partnerID=MN8TOARS.
    10.1016/j.theriogenology.2016.06.023
Thesis / Dissertation
  1. "Ação de compostos bioativos em câncer de tireoide". PhD, Universidade Federal de São Paulo, 2022. https://repositorio.unifesp.br/items/a58c8beb-8a86-4b31-b70f-d536bb12bba7.
  2. "Pesquisa de causas genéticas do câncer não medular familial da tireoide". Master, Universidade Federal de São Paulo, 2017. https://repositorio.unifesp.br/items/4ac557d8-8ef7-41be-8fc7-02cdcc416bce.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/08 - 2019/12 ESTUDO DA EXPRESSÃO DO COMPLEXO REPRESSOR DE POLYCOMB 2 EM LINHAGENS CELULARES DE CÂNCER DE TIREOIDE TRATADAS COM IODO
Co-supervisor
 Ciências Biológicas (Degree)
Universidade Federal de São Paulo, Brazil
Distinctions

Award

2020 Best Oral Poster Presentation
Departamento de Tireoide da Sociedade Brasileira de Endocronologia e Metabologia, Brazil