Luís Manuel Redondo Raposo (1713-9EB0-7CBA)

Curriculum Vitae

Luís Manuel Redondo Raposo

Luís Manuel Redondo Raposo. Completed the Doutoramento in Biologia in 2016/12/21 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Mestrado in Biotecnologia (Engenharia Bioquímica) in 2007/12/21 by Universidade de Lisboa Instituto Superior Técnico and Licenciatura in Biologia Microbiana e Genética in 1999/12/19 by Universidade de Lisboa Faculdade de Ciências. Published 31 articles in journals. Organized 7 event(s). Participated in 2 event(s). Co-supervised 3 work(s) of course completion of LSc/BSc. Participates and/or participated as PhD Student Fellow in 1 project(s), Post-doc in 5 project(s), Post-doc Fellow in 2 project(s), Research Fellow in 1 project(s) and Researcher in 2 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Gene-based Diagnostics and Therapeutic Interventions, Medical and Health Sciences with emphasis on Medical Biotechnology with emphasis on Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism, Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology, Engineering and Technology with emphasis on Industrial Biotechnology with emphasis on Biofuels and Natural sciences with emphasis on Biological Sciences with emphasis on Microbiology. In their professional activities interacted with 211 collaborator(s) co-authorship of scientific papers. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: produção de bioetanol; tolerância ao etanol; proteómica; engenharia de leveduras; Peptidases; Catabolismo; Bioenergética; Regulação da expressão; bacterial infection; virulence genes; Streptococcus dysgalactiae subsp dysgalactiae; host-patogen interactions; biotechnology; alcoholic fermentation; bioethanol; Inflammatory bowel diseases; colorectal cancer; Canine mammary tumors; Epithelial to mesenchymal transition; Chemotherapeutic compounds and nanotechnology; Quantitative proteomics; FR37-CMT; FR10-CMT; miRNA; canine mammary tumors; mRNA; Immortalized cell lines; Biologia Estrutural e Computacional; Bioquímica e Biologia Molecular; Marcadores Bioquímicos; Toxicologia; Innovative Diagnostics; Therapies and Devices; Tools for Drug Discovery & Development Pipeline; Human Safety and Antimicrobial Resistance; Bioprocesses & Circular Economy; Síntese; Catálise e Química de Coordenação; Química Bioinorgânica e Medicinal; Química de Materiais e Processos Fotoactivos; Termodinâmica de Fluidos e de Nanosistemas; Biomolecular Interactions; Drug Discovery and Development; Health and Environmental Safety; Environmental Bioengineering; Life Sciences; Precision Medicine; Biotechnology; Food Security; .

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Identification

Personal identification

Full name: Luís Manuel Redondo Raposo

Citation names

Raposo, Luís R
Raposo, Luís

Author identifiers

Ciência ID: 1713-9EB0-7CBA
ORCID iD: 0000-0002-8637-346X
Researcher Id: T-3754-2017
Scopus Author Id: 36793109300

Email addresses

l.raposo@alumni.fct.unl.pt (Professional)

Addresses

Unidade de Ciência Biomoleculares aplicadas no pólo da Faculdade de Ciências e Tecnologia UNL. Campus de Caparica, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

https://www.requimte.pt/ucibio/people/luis-raposo (Scholar)
http://orcid.org/0000-0002-8637-346X (Scholar)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Natural sciences - Biological Sciences - Molecular Biology
Engineering and Technology - Industrial Biotechnology - Biofuels
Natural sciences - Biological Sciences - Microbiology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Spanish; Castilian	Upper intermediate (B2)	Upper intermediate (B2)	Beginner (A1)	Intermediate (B1)	Intermediate (B1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2011/07/01 - 2016/12/21 Concluded	Biologia (Doutoramento) Major in Genética molecular Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Transcriptome and proteome profiling of canine mammary tumors: dog as a genetic model for unraveling mammary cancer molecular signatures" (THESIS/DISSERTATION)	Aprovado
2005/09/01 - 2007/12/21 Concluded	Biotecnologia (Engenharia Bioquímica) (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal ""Global analysis of the yeast's mechanisms of resistance to high concentrations of ethanol and glucose" - Análise global dos mecanismos de resistência da levedura a stresse induzido por concentrações elevadas de etanol e glucose" (THESIS/DISSERTATION)	Aprovado
1994/10/01 - 1999/12/19 Concluded	Biologia Microbiana e Genética (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal ""Study of genetic alterations in cancerigenesis associated with chronic inflammatory diseases of the bowel" - Estudo de alterações genéticas na cancerigénese associada às doenças inflamatórias crónicas do intestino" (THESIS/DISSERTATION)	15 (Quinze)

Affiliation

Science

	Category Host institution	Employer
2020/10/01 - 2023/11	Principal Investigator (Research)	Nano4 Global, Lda, Portugal

2019/12/09 - 2020/09/30	Postdoc (Research)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal (...)
2017/05/01 - 2019/12/08	Postdoc (Research)	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2003/11/03 - 2011/06/30	Research Assistant (Research)	Universidade Lusófona de Humanidades e Tecnologias, Portugal

2002/10/01 - 2003/09/30	Researcher (Research)	Instituto de Biologia Experimental e Tecnológica, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2006 - 2011	Invited Assistant Professor (University Teacher)	Universidade Lusófona de Humanidades e Tecnologias, Portugal

Others

	Category Host institution	Employer
2001/10 - 2007/07	Highschool Life Sciences Teacher	Escola Pré-Universitária Autónoma, Portugal

Projects

Grant

	Designation	Funders
2018/10/01 - 2021/09/30	Marine invertebrates as source of novel biotoxins: Investigating function and application through Polychaeta venomics PTDC/BTA-BTA/28650/2017 Researcher REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2019/12/09 - 2020/09/30	Detection and characterization of nanoparticles using solid state nanopores: a single molecule approach - Detecção e Caracterização de Nanopartículas Usando Nanoporos de Estado Sólido: Uma Abordagem Única Molécula PTDC/NAN-MAT/31100/2017 Post-doc Fellow Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2017/05 - 2019/05	Unveiling host specificity and host-pathogen interactions of Streptococcus - Avaliação da especificidade do hospedeiro e das interacções agente patogénico-hospedeiro em Streptococcus 66151 Provided by PTCRIS: 66151 PTDC/CVT-EPI/6685/2014 Post-doc Fellow	Fundação para a Ciência e a Tecnologia Ongoing
2011/07/01 - 2015/06/30	Transcriptome and proteome profiling of canine mammary tumors: dog as a genetic model for unraveling mammary cancer molecular signatures SFRH/BD/70202/2010 PhD Student Fellow Universidade de Lisboa Centro de Química Estrutural, Portugal REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/07/01 - 2010/06/30	Proteomics and engineering of ethanol tolerant yeasts for high productivity of bio-ethanol fermentation processes - PROBIOETANOL - PROTEÓMICA E ENGENHARIA DE LEVEDURAS TOLERANTES A ETANOL NA OBTENÇÃO DE PROCESSOS FERMENTATIVOS DE BIO-ETANOL DE ELEVADA PRODUTIVIDADE PTDC/BIO/66151/2006 Researcher Instituto de Biotecnologia e Bioengenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2002/10/01 - 2003/09/30	Caracterization of peptide catabolism by lactic bacteria of wine and meat products - CARACTERIZAÇÃO DO CATABOLISMO DE PÉPTIDOS EM BACTÉRIAS LÁCTICAS DE VINHO E PRODUTOS CÁRNEOS POCTI/AGR/39613/2001 Research Fellow Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2023/09/01 - Current	Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 10.54499/LA/P/0087/2020 Post-doc Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade Nova de Lisboa Molecular Structural and Cellular Microbiology, Portugal Universidade Nova de Lisboa, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Gulbenkian de Ciência, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal BioResources 4 Sustainability, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - 2025/12/31	Institute for Health and Bioeconomy LA/P/0140/2020 10.54499/LA/P/0140/2020 Post-doc Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal Universidade Nova de Lisboa, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal INESC Microsistemas e Nanotecnologias, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - 2023/12/31	Applied Molecular Biosciences Unit UIDP/04378/2020 10.54499/UIDP/04378/2020 UIDB/04378/2020 10.54499/UIDB/04378/2020 Post-doc Universidade do Porto, Portugal Universidade Nova de Lisboa, Portugal Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Unidade de Ciências Biomoleculares Aplicadas, Portugal Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Unidade de Ciências Biomoleculares Aplicadas UID/Multi/04378/2019 154717UID Post-doc Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	Centro de Química Estrutural UID/QUI/00100/2019 Post-doc Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Conference abstract	ISABEL Maria SÁ-CORREIA Leite de Almeida; Miguel Nobre Parreira Cacho Teixeira; Nuno Gonçalo Pereira Mira; Raposo, Luís R; Artur Pedro Duarte Reis Bastos Lourenço. "Genome-wide requirements for maximum tolerance to ethanol and acids in Saccharomyces cerevisiae". Paper presented in Yeast Genetics and Molecular Biology Conference, Manchester, 2009. Published • 10.1002/yea.1682
Conference poster	Raposo, Luís R; Catarina Roma-Rodrigues; João Jesus; Joaquim Henriques; Pedro Faísca; Margarida Alves; Jorge Correia; Pedro Viana Baptista; Alexandra R Fernandes. "New models of mammary tumors for drug development". Paper presented in Ciência 2016 - Encontro de Ciência 2016, 2016. Raposo, Luís R; Catarina Roma-Rodrigues; Joaquim Henriques; Pedro Faísca; Margarida Alves; Jorge Correia; Alexandra R Fernandes. "Molecular characterization of miRs and mRNAs in canine mammary tumours and their role biomarkers in the metastatic progression". Paper presented in II Jornadas NOVA Saúde 2015, 2015. Roma-Rodrigues, Catarina; Cinthia Alves-Barroco; João Caço; Raposo, Luís; Mafalda N. Costa; Elvira Fortunato; Pedro V. Baptista; Alexandra R. Fernandes; Ilda Santos-Sanches. "Analysis of adherence and internalization into human cells by bovine mastitis Streptococcus dysgalactiae subsp. dysgalactiae". Paper presented in Microbiotec’15, 2015. Raposo, Luís R; Joaquim Henriques; Pedro Faísca; Margarida Alves; Jorge Correia; Maria Alexandra Núncio de Carvalho Ramos Fernandes. "Molecular characterization of canine mammary tumours: the role of miRs and mRNAs as biomarkers in the metastatic transition". Paper presented in European Society of Veterinary Oncology Annual Congress, ESVONC 2014, 2014. João Conde; Miguel Larguinho; Ana Cordeiro; Raposo, Luís R; Costa, Pedro M. (281C-7BD4-10C5); Mário S Diniz; Maria Alexandra Núncio de Carvalho Ramos Fernandes; Pedro V. Baptista. "Gold-Nanobeacons for gene silencing: evaluation of the effect and toxicity of a new nanotheranostics tool". Paper presented in European Conference of Human Genetics, 2013. Raposo, Luís R; Susana Santos; Joaquim Henriques; Margarida Alves; Pedro Faísca; André Beselga; Jorge Correia; Maria Alexandra Núncio de Carvalho Ramos Fernandes. "Insights into the molecular basis of canine mammary cancer: the use of miRs in the characterization of canine mammary tumors". Paper presented in European Society of Veterinary Oncology Annual Congress, ESVONC, 2013. Raposo, Luís R; Susana Santos; Joaquim Henriques; Margarida Alves; Pedro Faísca; André Beselga; Jorge Correia; Maria Alexandra Núncio de Carvalho Ramos Fernandes. "Immortalization of primary canine cell lines from mammary tumors: a protocol optimization". Paper presented in XVIII Meeting of the Portuguese Society of Animal Pathology, 2013. Ana Cordeiro; Miguel Larguinho; João Conde; Raposo, Luís R; Costa, Pedro M.; Mário S Diniz; Maria Alexandra Núncio de Carvalho Ramos Fernandes; Pedro Miguel Viana Baptista. "Analyzing the toxicologic potential of an antisense Au-nanobeacon system for gene therapy". Paper presented in Encontro Nacional de Nanotoxicologia - E2N 2013, 2013. Helena Isabel Santos; Raposo, Luís R; Rogerio Paulo Andrade Tenreiro; JJ Figueireido Marques; Maria Teresa Ferreira de Oliveira Barreto Goulão Crespo. "Diversity of microbial genomes associated with the maturation of ewe's cheeses". Paper presented in XXXI Jornadas Portuguesas de Genética, 2004. Paula Fareleira; Helena Isabel Santos; Raposo, Luís R; Rogerio Paulo Andrade Tenreiro; Maria Teresa Ferreira de Oliveira Barreto Goulão Crespo; JJ Figueiredo Marques. "Can empirical knowledge about complex systems be translated into scientific language? A study case in Azeitão cheese making". Paper presented in National Congress of Microbiology, 2003. Helena Isabel Santos; JJ Figueiredo Marques; Raposo, Luís R; Rogerio Paulo Andrade Tenreiro; Maria Teresa Ferreira de Oliveira Barreto Goulão Crespo. "Microbial ecology of portuguese ewe’s cheese". Paper presented in I congress of the Federation of European Microbiological Societies, 2003.
Journal article	Inês C. B. Martins; Andreia Forte; Hermínio P. Diogo; Luís R. Raposo; Pedro V. Baptista; Alexandra R. Fernandes; Luís C. Branco; M. Teresa Duarte. "A solvent-free strategy to prepare amorphous salts of folic acid with enhanced solubility and cell permeability". Chemistry–Methods (2022): https://doi.org/10.1002/cmtd.202100104. 10.1002/cmtd.202100104 Arezoo Saadati; Mahnaz Aryaeifar; Olivier Blacque; Rui Cabral; Luis R. Raposo; Alexandra R. Fernandes; Hadi Amiri Rudbari; Jose V. Cuevas-Vicario. "Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NN'O] ligands: Synthesis, characterization, structural investigations and antiproliferative activity". Bioorganic Chemistry 119 (2022): 105556-105556. http://dx.doi.org/10.1016/j.bioorg.2021.105556. 10.1016/j.bioorg.2021.105556 Ana R. Jesus; Luís R. Raposo; Mário R. C. Soromenho; Daniela A. S. Agostinho; José M. S. S. Esperança; Pedro V. Baptista; Alexandra R. Fernandes; Patrícia M. Reis. "New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs". Symmetry (2021): https://doi.org/10.3390/sym13112053. 10.3390/sym13112053 Joanna Palion-Gazda; André Luz; Luis R. Raposo; Katarzyna Choroba; Jacek E. Nycz; Alina Bienko; Agnieszka Lewinska; et al. "Vanadium(IV) Complexes with Methyl-Substituted 8-Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activity". Molecules 26 21 (2021): 6364-6364. https://doi.org/10.3390/molecules26216364. 10.3390/molecules26216364 Katarzyna Choroba; Barbara Machura; Agata Szlapa-Kula; Jan G. Malecki; Luís Manuel Redondo Raposo; Catarina Roma-Rodrigues; Sandra Cordeiro; Pedro V. Baptista; Alexandra R. Fernandes. "Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2':6',2¿-terpyridine ligands: From in vitro to in vivo biological properties". European Journal of Medicinal Chemistry 218 (2021): 113404-113404. https://doi.org/10.1016/j.ejmech.2021.113404. 10.1016/j.ejmech.2021.113404 Francisco Reigosa-Chamorro; Luís R. Raposo; Paula Munín-Cruz; M. Teresa Pereira; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes; José M. Vila. "In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.0c03763. 10.1021/acs.inorgchem.0c03763 Lorenzo Rivas-García; José L. Quiles; Catarina Roma-Rodrigues; Luis R. Raposo; María D. Navarro-Hortal; Jose M. Romero-Márquez; Adelaida Esteban-Muñoz; et al. "Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease". Food and Chemical Toxicology 149 (2021): 112018-112018. https://doi.org/10.1016/j.fct.2021.112018. 10.1016/j.fct.2021.112018 Catarina Roma-Rodrigues; Luís R. Raposo; Rúben Valente; Alexandra R. Fernandes; Pedro V. Baptista. "Combined cancer therapeutics-Tackling the complexity of the tumor microenvironment". WIREs Nanomedicine and Nanobiotechnology (2021): https://doi.org/10.1002/wnan.1704. 10.1002/wnan.1704 Luís R. Raposo; Ana Silva; Dário Silva; Catarina Roma-Rodrigues; Margarida Espadinha; Pedro V. Baptista; Maria M.M. Santos; Alexandra R. Fernandes. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880-115880. https://doi.org/10.1016/j.bmc.2020.115880. 10.1016/j.bmc.2020.115880 Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; André Luz; Pedro V. Baptista; Giuseppe Bruno; et al. "Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities". Dalton Transactions (2021): https://doi.org/10.1039/D0DT03962D. 10.1039/D0DT03962D Luis R. Raposo; Katarzyna Choroba; Joanna Palion-Gazda; Ewa Malicka; Karol Erfurt; Barbara Machura; Alexandra R. Fernandes; et al. "In vitro antiproliferative effect of vanadium complexes bearing 8-hydroxyquinoline-based ligands - the substituent effect". Dalton Transactions (2020): https://doi.org/10.1039/D0DT01017K. Published • 10.1039/D0DT01017K Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; Pedro V. Baptista; Daniela Ferreira; Giuseppe Bruno; et al. "Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes". ACS Combinatorial Science 200 (2020): https://doi.org/10.1021/acscombsci.9b00202. Published • 10.1021/acscombsci.9b00202 Fernandes, Alexandra R.; Mendonça-Martins, Inês; Santos, Marino F. A.; Raposo, Luís R.; Mendes, Rita; Marques, Joana; Romão, Carlos C.; et al. "Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules". ACS Biomaterials Science & Engineering 6 2 (2020): 1090-1101. http://dx.doi.org/10.1021/acsbiomaterials.9b01936. Published • 10.1021/acsbiomaterials.9b01936 Das, K.; Datta, A.; Frontera, A.; Wen, Y. S.; Catarina Roma-Rodrigues; Raposo, Luís R; Maria Alexandra Núncio de Carvalho Ramos Fernandes; Hung, C. H.. "Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines". Journal of Inorganic Biochemistry (2020): http://dx.doi.org/10.1016/j.jinorgbio.2019.110881. Published • 10.1016/j.jinorgbio.2019.110881 Sutradhar, Manas; Alegria, Elisabete C.B.A.; Ferretti, Francesco; Raposo, Luís R.; Guedes da Silva, M. Fátima C.; Baptista, Pedro V.; Fernandes, Alexandra R.; Pombeiro, Armando J.L.. "Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers". Journal of Inorganic Biochemistry 200 (2019): 110811. http://dx.doi.org/10.1016/j.jinorgbio.2019.110811. Published • 10.1016/j.jinorgbio.2019.110811 Roma-Rodrigues, Catarina; Pombo, Inês; Raposo, Luís; Pedrosa, Pedro; Fernandes, Alexandra R.; Baptista, Pedro V.. "Nanotheranostics Targeting the Tumor Microenvironment". Frontiers in Bioengineering and Biotechnology 7 (2019): http://dx.doi.org/10.3389/fbioe.2019.00197. Published • 10.3389/fbioe.2019.00197 Santos, Miguel M.; Raposo, Luís; Carrera, Gonçalo V. S. M.; Costa, Alexandra; Dionísio, Madalena; Baptista, Pedro V.; Fernandes, Alexandra R.; Branco, Luís C.. "Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug". ChemMedChem 14 9 (2019): 907-911. http://dx.doi.org/10.1002/cmdc.201900040. Published • 10.1002/cmdc.201900040 Jesus, Ana R.; Soromenho, Mário R.C.; Raposo, Luís R.; Esperança, José M.S.S.; Baptista, Pedro V.; Fernandes, Alexandra R.; Reis, Patrícia M.. "Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids". European Journal of Pharmaceutics and Biopharmaceutics 137 (2019): 227-232. http://dx.doi.org/10.1016/j.ejpb.2019.03.004. Published • 10.1016/j.ejpb.2019.03.004 Katarzyna Choroba; Barbara Machura; Raposo, Luís (1713-9EB0-7CBA); Jan G. Malecki; Slawomir Kula; Michal Pajak; Karol Erfurt; Anna M. Maron; Alexandra R. Fernandes. "Platinum(ii) complexes showing high cytotoxicity toward A2780 ovarian carcinoma cells". Dalton Transactions 48 34 (2019): 13081-13093. https://doi.org/10.1039/C9DT02894C. Published • 10.1039/C9DT02894C Katarzyna Choroba; Barbara Machura; Slawomir Kula; Raposo, Luís; Alexandra R. Fernandes; Rafal Kruszynski; Karol Erfurt; et al. "Copper(ii) complexes with 2,2':6',2''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01922G. 10.1039/C9DT01922G Maron A; Czerwinska K; Machura B; Raposo L; Roma-Rodrigues C; Fernandes AR; Malecki JG; et al. "Spectroscopy, electrochemistry and antiproliferative properties of Au(iii), Pt(ii) and Cu(ii) complexes bearing modified 2,2':6',2''-terpyridine ligands.". Dalton transactions (Cambridge, England : 2003) (2018): http://europepmc.org/abstract/med/29688241. 10.1039/c8dt00558c Alves-Barroco, Cinthia; Roma-Rodrigues, Catarina; Raposo, Luís R.; Brás, Catarina; Diniz, Mário; Caço, João; Costa, Pedro M.; Santos-Sanches, Ilda; Fernandes, Alexandra R.. "Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models". MicrobiologyOpen 8 1 (2018): e00623. http://dx.doi.org/10.1002/mbo3.623. Published • 10.1002/mbo3.623 Raposo, Luís; C. Roma-Rodrigues; P. Faísca; M. Alves; J. Henriques; M. C. Carvalheiro; M. L. Corvo; et al. "Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT". Veterinary and Comparative Oncology (2017): https://doi.org/10.1111%2Fvco.12235. 10.1111/vco.12235 Raposo, L. R.; Roma-Rodrigues, C.; Jesus, J.; Martins, L. M. D. R. S.; Pombeiro, A. J.; Baptista, P. V.; Fernandes, A. R.. "Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds". Veterinary and Comparative Oncology 15 4 (2017): 1537-1542. http://dx.doi.org/10.1111/vco.12298. Published • 10.1111/vco.12298 Catarina Roma-Rodrigues; Luís Raposo; Rita Cabral; Fabiana Paradinha; Pedro Baptista; Alexandra Fernandes. "Tumor Microenvironment Modulation via Gold Nanoparticles Targeting Malicious Exosomes: Implications for Cancer Diagnostics and Therapy". International Journal of Molecular Sciences 18 1 (2017): 162-162. https://doi.org/10.3390%2Fijms18010162. Published • 10.3390/ijms18010162 Roma-Rodrigues, Catarina; Alves-Barroco, Cynthia; Raposo, Luís R; Costa, Mafalda N.; Fortunato, Elvira; Baptista, Pedro Viana; Fernandes, Alexandra R.; Santos-Sanches, Ilda. "Infection of human keratinocytes by Streptococcus dysgalactiae subspecies dysgalactiae isolated from milk of the bovine udder". Microbes and Infection 18 4 (2016): 290-293. http://dx.doi.org/10.1016/j.micinf.2015.11.005. Published • 10.1016/j.micinf.2015.11.005 Martins, Pedro; Jesus, João; Santos, Sofia; Raposo, Luís; Roma-Rodrigues, Catarina; Baptista, Pedro; Fernandes, Alexandra. "Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box". Molecules 20 9 (2015): 16852-16891. http://dx.doi.org/10.3390/molecules200916852. Published • 10.3390/molecules200916852 Roma-Rodrigues, Catarina; Raposo, Luís; Fernandes, Alexandra R.. "MicroRNAs Based Therapy of Hypertrophic Cardiomyopathy: The Road Traveled So Far". BioMed Research International 2015 (2015): 1-8. http://dx.doi.org/10.1155/2015/983290. Published • 10.1155/2015/983290 Conde, João; Larguinho, Miguel; Cordeiro, Ana; Raposo, Luís; Costa, Pedro M.; Santos, Susana; Diniz, Mário S.; Fernandes, Alexandra R.; Baptista, Pedro V.. "Gold-nanobeacons for gene therapy: evaluation of genotoxicity, cell toxicity and proteome profiling analysis". Nanotoxicology 8 5 (2013): 521-532. http://dx.doi.org/10.3109/17435390.2013.802821. Published • 10.3109/17435390.2013.802821 Teixeira, Miguel C.; Raposo, Luís; Palma, Margarida; Sá-Correia, Isabel. "Identification of Genes Required for Maximal Tolerance to High-Glucose Concentrations, as Those Present in Industrial Alcoholic Fermentation Media, Through a Chemogenomics Approach". OMICS: A Journal of Integrative Biology 14 2 (2010): 201-210. http://dx.doi.org/10.1089/omi.2009.0149. Published • 10.1089/omi.2009.0149 Teixeira, Miguel Cacho; Raposo, Luís; Mira, N. P.; Lourenco, A. B.; Isabel Sá-Correia. "Genome-Wide Identification of Saccharomyces cerevisiae Genes Required for Maximal Tolerance to Ethanol". Applied and Environmental Microbiology 75 18 (2009): 5761-5772. http://dx.doi.org/10.1128/aem.00845-09. Published • 10.1128/aem.00845-09
Thesis / Dissertation	Raposo, Luís R. "Transcriptome and proteome profiling of canine mammary tumors: dog as a genetic model for unraveling mammary cancer molucular signatures". PhD, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2016. https://run.unl.pt/handle/10362/20214. Raposo, Luís R. "Global analysis of the yeast's resistance mechanisms induced by high concentrations of ethanol and glucose - Análise global dos mecanismos de resistência da levedura ao stresse induzido por concentrações elevadas de etanol e glucose". Master, Universidade de Lisboa Instituto Superior Técnico, 2007. Raposo, Luís R. "Study of the genetic alterations in cancerigenesis associated with chronic inflammatory bowel diseases - Estudo de alterações genéticas na cancerigénese associada às doenças inflamatórias crónicas do intestino". Degree, Universidade de Lisboa Faculdade de Ciências, 1999.

Other

Other output

3D cell culture model for drug screening purposes. Case study for Cytosmart - Lux3 FL. 2020. Roma-Rodrigues, Catarina; Raposo, Luís R; Baptista, Pedro Viana; Alexandra R Fernandes. https://cytosmart.com/resources/case-studies/3-d-cell-culture-model-drug-screening-purposes.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2012	Antisense Gold Nanobeacons for Gene Therapy	NanoMed: International Conference on Nanotechnology in Medicine University College London (London, United Kingdom)
2009/12	Global analysis of yeast determinants of resistance to ethanol: the important role of FPS1	MICROBIOTEC'09 Sociedade portuguesa de microbiologia (Vilamoura, Portugal)
2009/07	Genome-wide requirements for maximum tolerance to ethanol and acids in Saccharomyces cerevisiae	Yeast Genetics and Molecular Biology Conference Federation of European Microbiological Societies (Manchester, United Kingdom)
2007/12	Insights into the mechanisms of yeast resistance to inhibitory concentrations of ethanol and glucose aiming the development of improved strains for bioethanol production	Micro’07-Biotec’07-XXXIII Jornadas de Genética Sociedade portuguesa microbiologia (Lisboa, Portugal)
1999/10	"A model for the study of genetic alterations induced by oxidative stress" - Modelo para estudo de alterações genéticas induzidas pelo stress oxidativo	III meeting of the SPGH Sociedade Portuguesa de Genética (Lisboa, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/01 - 2019/06	Characterization of the anti-tumor potential of new compounds for the treatment of cancer - Caracterização do potencial anti-tumoral de novos compostos para o tratamento do cancro Co-supervisor	Bioquímica (Degree) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/01 - 2017/06	Role of miRNAs on the metastization of canine mammary tumours - Papel dos mRNAs na Metastização de Tumores Mamários Caninos Co-supervisor	Bioquímica (Degree) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/01 - 2015/06	Alteration of gene expression in canine mammary tumors - Variação da expressão de genes, na presença de um tumor mamário na cadela Co-supervisor	Química Aplicada (Degree) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2018/09/01 - 2019/07/30	Member of organizing committee of the Pos-Doc annual meeting 2019 organized by LUPA at FCT-UNL (2019/01/25 - 2019/01/25) Conference (Member of the Organising Committee)
2013/07/04 - 2013/07/04	Creator and lecturer of the workshop "The fluorescent laboratory" for the 31st Youth Science Meeting held at FCT-UNL (2013/07/04 - 2013/07/04) Workshop (Other)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/07/05 - 2011/06/30	Creator, developer and lecturer of the "In vitro fertilization and mitosis in the sea urchin embriogenesis" workshop for the "Ciência Viva in the lab" program at ULHT (2010/07/05 - 2011/06/30) Workshop (Other)	Universidade Lusófona de Humanidades e Tecnologias, Portugal Ciência Viva, Portugal
2007/09 - 2011/06	Creator, developer and lecturer of the scientific outreach workshop "Gene cloning: Introduction to basic molecular biology techniques" for high school students that kickstarted the "Criar Saberes" program at ULHT. (2007/09 - 2011/06) Workshop (Other)	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2004/01 - 2011/06	Creator, developer and lecturer of the scientific outreach workshop "Chick embryonic development: the vertebrate basic organization" for high school students that kickstarted the "Criar Saberes" program at ULHT. (2004/01 - 2011/06) Workshop (Other)	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2004 - 2011/06	Creator, developer and lecturer of the scientific outreach workshop "The sea urchin embryonic development: fertilization and early development" for high school students that kickstarted the "Criar Saberes" program at ULHT. (2004/01 - 2011/06) Workshop (Other)	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2007/11/30 - 2007/12/02	Staffer in the microbiology, biotechnology and genetics 2007 congress - Micro'07 Biotec’07 XXXIIIdJPG (2007/11/30 - 2007/12/02) Congress (Other)

Event participation

	Activity description Type of event	Event name Institution / Organization
2014/05/22 - 2014/05/24	European Society of Veterinary Oncology Annual Congress, ESVONC 2014, attendee Congress	European Society of Veterinary Oncology Annual Congress, ESVONC European Society of Veterinary Oncology, ESVONC, Netherlands
2013/05/30 - 2013/06/01	European Society of Veterinary Oncology Annual Congress, ESVONC 2013, attendee Congress	European Society of Veterinary Oncology Annual Congress, ESVONC 2013 European Society of Veterinary Oncology, ESVONC, Netherlands

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2019/06	Identificação de transcritos de BCR-ABL1 e deteção de mutações pontuais no domínio ABL1 (Thesis) Arguer	Beatriz Varatojo Costa (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/06	Characterization of the anti-tumor potential of new compounds for the treatment of cancer - Caracterização do potencial anti-tumoral de novos compostos para o tratamento do cancro Supervisor	André Filipe Machado da Luz (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/06	Development of standard curves using 18S and cMYC for absolute quantitative PCR analysis (Thesis) Arguer	Delfina Patrícia Henriques Pereira (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/06	AD453 - Novel compound wit anticancer potential: biologic targets and new combinatory strategies - AD543 - Composto inovador com potencial anticancerígeno: alvos biológicos e novas terapêuticas combinatórias (Thesis) Arguer	Rita Patrício Fernandes (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/06	Role of miRNAs on the metastization of canine mammary tumours - Papel dos mRNAs na Metastização de Tumores Mamários Caninos Supervisor	Beatriz dos Santos Pinto Soromenho (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/06	Alteration of gene expression in canine mammary tumors - Variação da expressão de genes, na presença de um tumor mamário na cadela Supervisor	Vanessa Cristina Tavares da Silva Almeida. (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2006/12	"Genetic Typing of Leishmania infantum isolates by microssatelite analysis" - Tipagem Genética de Isolados de Leishmania infantum por análise de microssatélites. (Thesis) Arguer	Carla Lopes (Other) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2019/09/27 - 2019/09/27	Lesão e Morte Celular - "Lesion and Cell death": course lecture on Apoptosis	Genética Molecular e Biomedicina (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/09/28 - 2018/09/28	Lesão e Morte Celular - "Lesion and Cell death" course: lecture on Apoptosis	Genética Molecular e Biomedicina (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/09 - 2011/07	Bioinformática - "Bioinformatics"	Biologia (Licenciatura)	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/09 - 2010/07	Bioquímica I - "Biochemistry I"	Ciências Farmacêuticas (Mestrado integrado)	Universidade Lusófona de Humanidades e Tecnologias, Portugal
2006/09 - 2007/07	Biologia Geral - "General Biology"	Engenharia do Ambiente (Licenciatura)	Universidade Lusófona de Humanidades e Tecnologias, Portugal