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Alícia Candeias is a Senior Technician hired by NOVA School of Science and Technology (NOVA-FCT) to work at the BioNMR Lab and GlycoLab from the Applied Molecular Biosciences Unit (UCIBIO) at NOVA-FCT. She is actively working in the EU-funded GLYCOTwinning project (HORIZON-WIDERA-2021-101079417). She belongs to the GLYCOTwinning Students Committee at UCIBIO. The passion for Glycoscience started since the early beginning of her research path. Alícia completed her Master's degree in Biochemistry in 2022 and her Bachelor's degree in Biochemistry in 2020, both from the NOVA-FCT. Her Bachelor's thesis was important to be trained in ELISA and flow cytometry in glycobiology field. During her Master's thesis, she has developed valuable experience on protein expression and purification of glycan-binding protein (GBPs). Also, she gained skills in protein crystallization, data processing and 3D structure solution via Molecular Replacement methods, electron density maps calculation and interpretation, model building and 3D structure validation. This training was pivotal to solving and interpreting protein structures, isolated and in complex with relevant glycans. After obtaining her Master's degree, she held a prestigious Research Fellowship under the GlycoMed project (LISBOA-01-0247-FEDER-047033) within the Macromolecular Crystallography & GlycoLab Groups (UCIBIO, NOVA-FCT), further enriching her expertise, working at the interface of Structural Biology and Glycobiology. More recently, following her Master’s thesis research line and in the framework of GLYCOTwinning project, she is focused on deciphering, at a molecular level, novel GBPs produced by commensal bacteria and their profound impact on host biology, through the exhaustive study of host mucin O-glycans/bacterial GBPs interactions. To do this, Alícia currently integrates different techniques and methodologies from glycomics (glycan microarrays) to structural biology (NMR & X-ray Crystallography) approaches. Also, in the scope GLYCOTwinning, Alícia has been receiving training in producing mucins (e.g. MUC1) and in chemoenzymatic methods to produce MUC glycodomains, to investigate mucin O-glycans binding specificity and molecular recognition using glycan microarrays, NMR and X-ray Crystallography. Finally, she is also engaged as team member in two additional FCT-funded research projects (2022.06104.PTDC and 2023.00074.RESTART) expressing and purifying GBPs from commensal (Bacteroides species) and pathogenic bacteria (Salmonella species). Her research findings have resulted in 11 conference posters and 3 oral communications. She has attended 4 conferences, two of which were international, thus, sharing her work with a broad audience. Alícia's dedication to advancing scientific knowledge extends beyond her research, as evidenced by her active participation in the organization of 7 events and activities aimed at promoting research awareness across diverse audiences, bringing together researchers to share their findings with their peers.
Identification

Personal identification

Full name
Alícia Candeias

Citation names

  • Candeias, Alícia

Author identifiers

Ciência ID
181B-678A-70BD
ORCID iD
0000-0001-6068-5695

Email addresses

  • ai.candeias@fct.unl.pt (Professional)
  • aliciacandeias@hotmail.com (Personal)

Addresses

  • BioNMR & GlycoLab - Functional Glycobiology Groups, UCIBIO - Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemical Research Methods

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2022/09 - 2023/06
Concluded
Curso de Iniciação à Investigação em Ciências Biomoleculares (Pós-Graduação)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
20
2020/09 - 2022/12
Concluded
Bioquímica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"A molecular view on how a commensal bacterium thrives in the human gut" (THESIS/DISSERTATION)
18
2017/09 - 2020/07/09
Concluded
Bioquímica (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Evaluation of antibody specificity against tumor-associated glycans" (THESIS/DISSERTATION)
15
Affiliation

Science

Category
Host institution
Employer
2022/09/15 - 2023/06/30 Research Assistant (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Other Careers

Category
Host institution
Employer
2023/10/06 - Current Técnico Superior (Técnico Superior) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Projects

Grant

Designation Funders
2022/09/15 - 2023/06/30 GlycoMed: A new generation of enzymes for biofilm dispersion and immunomodulation in cancer (LISBOA-01-0247-FEDER-047033)
LISBOA-01-0247-FEDER-047033
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2022/09 - 2022/10 Summer with Science 2021 (Escola de Verão UCIBIO-NOVA - Iniciação à Investigação em Ciências Biomoleculares Aplicadas)
#Verão Com Ciência
Scientific Initiation Fellow
Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2024/01/01 - Current Unravelling mucin O-glycans and Salmonella SiiE adhesin crosstalk: a promise target for anti-adhesion therapy
2023.00074.RESTART
Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/10/06 - Current GlycOSELECT: Targeting a toolbox of microbiome O-Glycan-Selective proteins towards new approaches in cancer research
2022.06104.PTDC
Researcher
Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Instituto para a Saúde e a Bioeconomia
LA/P/0140/2020
Técnico Superior
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/10/06 - 2025/11/30 GLYCOTwinning: Building Networks to Excel in Glycosciences
101079417
Researcher
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Horizon 2020
Ongoing
2020/01/01 - 2023/12/31 Unidade de Ciências Biomoleculares Aplicadas
UIDP/04378/2020
Técnico Superior
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Unidade de Ciências Biomoleculares Aplicadas
UIDB/04378/2020
Técnico Superior
Universidade Nova de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Correia, Viviana G.; Costa, Raquel L.; Trovão, Filipa; Candeias, Alícia; Andrade Pinheiro, Benedita. Corresponding author: Andrade Pinheiro, Benedita. "The bacterial toolkit for glycan recognition in the human gut". In Carbohydrate Chemistry ¿ Chemical and Biological Approaches. 2024.
    Accepted
Conference poster
  1. Candeias, Alícia; Pinheiro, Benedita; Palma, Angelina S.; Marcelo, Filipa; Coelho, Helena. Corresponding author: Coelho, Helena. "Mucin O-glycan recognition by Salmonella SiiE adhesin for targeted anti-adhesion therapy". Paper presented in 4th Meeting of Young Biophysicists - Biophysics Festival, 2024.
  2. Candeias, Alícia; Trovão, Filipa; Oliveira Soares, Cátia; Grosso, Ana Sofia; Marcelo, Filipa; Pinheiro, Benedita; Carvalho, Ana Luísa; Palma, Angelina S.. Corresponding author: Candeias, Alícia. "Structural elucidation of a novel Carbohydrate-binding module from Bacteroides caccae targeting tumor-associated mucin O-glycans". Paper presented in How Time-Resolved X-ray Crystallography is driving Structural Biology forward – Workshop, 2024.
  3. Pinheiro, B. A.; Trovão, Filipa; Correia, V.G.; Costa, R.L.; Candeias, Alícia; Di Maio, A.; Feizi, Ten; et al. "Discovery and characterization of O-glycan selective proteins from the human gut microbiota". Paper presented in 7th Iberian Carbohydrate Meeting, 2024.
  4. Candeias, Alícia; Trovão, Filipa; Oliveira Soares, Cátia; Grosso, Ana Sofia; Marcelo, Filipa; Pinheiro, Benedita; Carvalho, Ana Luísa; Palma, Angelina S.. Corresponding author: Candeias, Alícia. "A novel Carbohydrate-binding module from Bacteroides caccae targeting tumour-associated mucin O-glycans". Paper presented in 7th Iberian Carbohydrate Meeting, 2024.
  5. Leite, Marlene; Candeias, Alícia; Oliveira Soares, Cátia; Pinheiro, Benedita; Dias, Jorge S; Palma, Angelina S.; Marcelo, Filipa; Coelho, H.. Corresponding author: Coelho, H.. "Decoding Salmonella adhesins: Unravelling molecular interactions for novel anti-infection strategies". Paper presented in 7 th Iberian Carbohydrate Meeting, 2024.
  6. Candeias, Alícia; Trovão, Filipa; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "Structural insights on the recognition of mucin O-glycans by a novel member of family 32 CBM from Bacteroides caccae". Paper presented in 1st GLYCOTwinning Summer School, 2023.
  7. Trovão, Filipa; Andrade Pinheiro, Benedita; Candeias, Alícia; Abrahams, Jodie; Di Maio, Antonio; Yu, Jin; Chai, Wengang; et al. "Molecular recognition on Mucin O-glycans by a human gut commensal ¿ Bacteroides caccae". Paper presented in Structural Glycoscience Summer School, 2023.
  8. Candeias, Alícia; Trovão, Filipa; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "Structural basis for recognition of mucin O-glycans by a novel member of family 32 CBM from Bacteroides caccae". Paper presented in XIII Jornadas de Carbohidratos (Spanish Carbohydrate Meeting), 2023.
  9. Candeias, Alícia; Trovão, Filipa; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "The 3D structure of BC16100-C, a novel protein from Bacteroides caccae, in complex with the Tn antigen reveals the molecular determinants that allow this bacterium to recognise host glycoproteins". Paper presented in GLUPOR14 - 14th International Meeting of the Portuguese Carbohydrate Group, 2023.
  10. Trovão, Filipa; Candeias, Alícia; Pinheiro, Benedita; Palma, Angelina S.; Carvalho, Ana Luísa. Corresponding author: Candeias, Alícia. "Structural insights on the glycan-binding function of a novel protein from Bacteroides caccae, a commensal bacterium from the human gut". Paper presented in 2nd National Crystallographic Meeting, 2022.
  11. Trovão, Filipa; Candeias, Alícia; Pinheiro, Benedita; Liu, Yan; Carvalho, Ana Luísa; Palma, Angelina S.. Corresponding author: Trovão, Filipa. "Structural elucidation of novel glycan-binding proteins from Bacteroides caccae - a resident of the human gut microbiota". Paper presented in Diamond-CCP4 Data Collection and Structure Solution Workshop, 2021.
Thesis / Dissertation
  1. "A molecular view on how a commensal bacterium thrives in the human gut". Master, REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, 2022.
  2. "Evaluation of antibody specificity against tumor-associated glycans". Degree, REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, 2020.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/15 A novel Carbohydrate-binding module from Bacteroides caccae targeting tumour-associated mucin O-glycans (Poster Pitch) 7th Iberian Carbohydrate Meeting
Carbohydrate Groups of the Real Sociedad Española de Química (RSEQ) and Sociedade Portuguesa de Química (SPQ) (Sitges, Spain)
2023/03/27 Structural basis for recognition of mucin O-glycans by a novel member of family 32 CBM from Bacteroides caccae (Poster Pitch) XIII Jornadas de Carbohidratos (Spanish Carbohydrate Meeting)
Institut Quimic de Sarrià, University Ramon Llull (Barcelona, Spain)
2022/02/10 A molecular view on how a commensal bacterium thrives in the human gut Jornadas intercalares das Dissertações Anuais dos Mestrados dos Departamentos de Química e de Ciências da Vida 2022
(Caparica, Portugal)

Event organisation

Event name
Type of event (Role)
Institution / Organization
2024/04/10 - 2024/04/10 Volunteer at EXPO FCT NOVA 2024: “GlicoMostra: a vida e os açúcares” (2024/04/10 - 2024/04/10)
Exhibition
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/04/19 - 2023/04/19 Volunteer at EXPO FCT NOVA 2023: “As interações hidrato de carbono-proteína e o seu papel no corpo humano” (2023/04/19 - 2023/04/19)
Exhibition
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/01/16 - 2023/01/18 GLUPOR 14 - 14th International Meeting of the Portuguese Carbohydrate Group (2023/01/16 - 2023/01/18)
Conference (Member of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/30 - 2022/09/30 Noite Europeia dos Investigadores 2022: Açúcares: Mais do que apenas doces moléculas! (2022/09/30 - 2023/09/30)
Exhibition
2022/07/10 - 2022/07/15 Volunteer at 7th European Crystallographic School (2022/07/10 - 2022/07/15)
Workshop
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/04/27 - 2022/04/27 Volunteer at EXPO FCT NOVA 2022: O estudo das interações do microbioma humano a nível molecular (2022/04/27 - 2022/04/27)
Exhibition
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/04/24 - 2019/04/24 Volunteer at ExpoFct 2019 - General Organization (2019/04/24 - 2019/04/24)
Exhibition
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/02/22 - 2024/02/22 How Time-Resolved X-ray Crystallography is driving Structural Biology forward – Workshop
Workshop
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/01/15 - 2024/01/17 7th Iberian Carbohydrate Meeting
Conference
7th Iberian Carbohydrate Meeting, Sitges, Barcelona
Real Sociedad Espanola de Quimica, Spain

Sociedade Portuguesa de Química, Portugal
2023/09/25 - 2023/09/28 Scientific hands-on course in protein/glycan interactions: a structural perspective
Other
1st GLYCOTwinning Summer School
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
2023/03/27 - 2023/03/29 XIII Jornadas de Carbohidratos (Spanish Carbohydrate Meeting)
Conference
XIII Jornadas de Carbohidratos (Spanish Carbohydrate Meeting), Institut Quimic de Sarrià, University Ramon Llull
2022/07/15 - 2022/07/16 2nd National Crystallographic Meeting
Conference
2nd National Crystallographic Meeting
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019 Biochemistry JORTEC (Jornadas Tecnológicas)
Conference
Biochemistry JORTEC (Jornadas Tecnológicas)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Committee member

Activity description
Role
Institution / Organization
2023/10/06 - Current GLYCOTwinning Students Committee
Member
Unidade de Ciências Biomoleculares Aplicadas, Portugal
Distinctions

Other distinction

2022 Research Fellowship under the project GlycoMed: A new generation of enzymes for biofilm dispersion and immunomodulation in cancer (LISBOA-01-0247-FEDER-047033)
2021 Research Initiation Fellowship under the programme Verão com Ciência 2021