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Identification

Personal identification

Full name
Maria Inês Veiga de Almeida Barros

Citation names

  • Barros, Inês
  • Barros, Maria Inês

Author identifiers

Ciência ID
181E-7AB3-4734
ORCID iD
0000-0002-3893-6416

Email addresses

  • mibarros@cnc.uc.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Spanish; Castilian Elementary (A2) Elementary (A2) Beginner (A1) Intermediate (B1)
Education
Degree Classification
2019 - 2024
Concluded
 PhD Programme in Experimental Biology and Biomedicine (Doutoramento)
Major in Biotechnology and Health
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/11/15
Concluded
 III Modular Training in Laboratory Animal Science Function A (Outros)
Center for Neuroscience and Cell Biology, Portugal
 18,6
2019/11/15
Concluded
 III Modular Training in Laboratory Animal Science Modules 20, 21 and 22 (Outros)
Center for Neuroscience and Cell Biology, Portugal
 15,8
2019
Concluded
 Master in Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease " (THESIS/DISSERTATION)
 18
2013 - 2016
Concluded
 Degree in Biochemistry (Licenciatura)
Major in Biochemistry
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Diabetic retinopathy and GLP-1-based " (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2024/05 - Current Researcher (Research) Universidade de Coimbra, Portugal
Center for Neuroscience and Cell Biology, Portugal

Others

Category
Host institution 		Employer
2019 - 2024 PhD student. Project: Unraveling Neurovascular Dysfunctions in Machado-Joseph Disease: Mesenchymal Stromal Cells as a Promising Therapy, supervised by: Luís Almeida, PhD; Catarina Miranda, PhD Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/05/22 - 2019/03/04 Master's Degree student. Project: Assessing the putative role of mesenchymal stromal cells ’effectors in Machado-Joseph disease; supervised by: Luís Almeida, PhD; Catarina Miranda, PhD CNC.IBILI, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/02/01 - 2016/06/01 Undergraduate student; Project: diabetic retinopathy and therapies based on glucagon-like peptide-1 hormone (GLP-1); supervised by: Rosa Fernades, PhD CNC.IBILI, Portugal
Projects

Contract

Designation Funders
2023/03/01 - 2024/08/31 Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
10.54499/2022.06127.PTDC
Research Fellow
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Gonçalves, Andreia; Barros, Inês; J Martins; C A. Gomes; C. Fontes-Ribeiro; Ambrósio, António Francisco; Fernades, Rosa. "Exendin-4, a glucagon-like peptide 1 analog, prevents the increase in blood-retinal barrier permeability and microglia activation in a type 1 diabetes animal model". Paper presented in Glia, 2017.
    Published
Conference poster
  1. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Lopes, Sara; Martins, Inês; Pereira de Almeida, L; Miranda, Catarina. Corresponding author: Miranda, Catarina. "The Guardians of Balance: Mesenchymal Stem Cells as a Promising Strategy to Restore Blood-brain Barrier Integrity in Spinocerebellar Ataxia Type 3.". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy, 2023.
  2. Lopes, Sara Monteiro; Miguel M. Lopes; Nobre, Rui Jorge; Vasconcelos-Ferreira, Ana; Pereira, Dina; Fernandes, Ana Rita; Barros, Maria Inês; et al. Corresponding author: Pereira de Almeida, Luis. "Targeting the ATXN3 gene with CRISPR-Cas9 for the therapy of Machado-Joseph disease". Paper presented in 30th Annual Meeting of the European Society of Gene & Cell Therapy (ESGCT), Brussels, Belgium, 2023.
  3. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Corresponding author: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Paper presented in FENS Regional Meeting 2023 (FRM), 2023.
  4. Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina. "Mesenchymal Stromal Cells Uptake Mutant Aatxin-3 and Alleviate Late Autophagy and Mitophagy impairments in Spinocerebellar ataxia type-3 (In Vitro and In Vivo) Models.". Paper presented in Congresso Anual SPDMov 2023, 2023.
  5. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Paper presented in 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  6. Silva, António; Barros, Inês; Lobo, Diana Duarte; Gonzaga, Daniela; Pereira de Almeida, Luis ; Miranda, Catarina. Corresponding author: Miranda, Catarina. "Mesenchymal Stromal Cells therapy rescues mitophagy in Machado-Joseph Disease models.". Paper presented in 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  7. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Corresponding author: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Paper presented in 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  8. Barros, Inês; Silva, António; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Pereira de Almeida, Luis ; Oliveira Miranda, Catarina. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  9. Barros, Inês; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Gomes, Célia; Oliveira Miranda, Catarina; Pereira de Almeida, Luis. "Assessing the putative role of mesenchymal stromal cells' effectors in Machado-Joseph disease". Paper presented in 1st Annual meeting in Pharmaceutical Sciences in Coimbra, Portugal, 2019.
  10. Costa, L.; Barros, Inês; Gonçalves, A.; Gomes, Célia; Fontes-Ribeiro, C.; Ambrósio, António Francisco; Fernandes, Rosa. "The glucagon-like peptide 1 receptor agonist Exendin-4 prevents diabetes-induced retinal vascular dysfunction and microglia activation". Paper presented in III Symposium of the Portuguese Glial Network, Porto, 2018.
  11. Fernandes, Rosa; Gonçalves, Andreia; Barros, Inês; Costa, L.; Gomes, Célia; Ambrósio, António Francisco. "O agonista do receptor do GLP-1, exendina-4, previne o aumento da permeabilidade da barreira hemato-retiniana e a ativação das células da micróglia num modelo animal de diabetes do tipo 1". Paper presented in 14º Congresso Português de Diabetes, Vilamoura, 2018.
  12. Gonçalves, Andreia; Barros, Inês; Martins, J.; Gomes, Célia; Fontes-Ribeiro, C.; Ambrósio, António Francisco; Fernandes, Rosa. "Exendin-4, a glucagon-like peptides 1 analog, prevents the increase in blood-retinal barrier permeability and microglia activation in a type 1 diabetes animal model.". Paper presented in XIII European Meeting on Glial Cells in Health and Disease, 2017.
Journal article
  1. Patrícia Pereira; Ana S. Neto; Ana S. Rodrigues; Inês Barros; Catarina Miranda; Joao Ramalho-Santos; Pereira de Almeida L; et al. "In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration". Polymers 15 10 (2023): 2256-2256. http://dx.doi.org/10.3390/polym15102256.
    10.3390/polym15102256
  2. Ana S. Neto; Patrícia Pereira; Ana C. Fonseca; Carla Dias; Mariana C. Almeida; Inês Barros; Catarina O. Miranda; et al. "Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair". Polymers (2021): https://doi.org/10.3390/polym13244378.
    10.3390/polym13244378
  3. Barros, Inês; Silva, António; Pereira de Almeida, Luis ; Oliveira Miranda, Catarina. "Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy". Cytokine & Growth Factor Reviews (2020): http://dx.doi.org/10.1016/j.cytogfr.2020.12.002.
    Published • 10.1016/j.cytogfr.2020.12.002
  4. Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luis ; Miranda, Catarina. "Mesenchymal Stromal Cells' Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.584277.
    Published • 10.3389/fncel.2020.584277
  5. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    10.1016/j.ymthe.2018.07.007
Newspaper article
  1. Vinhas, Ana Catarina; Ferreira, Ana Cristina; Henriques, Carina; Oliveira Miranda, Catarina; Silva, Carolina; Henriques, Daniel; Rufino-Ramos, David; et al. "Uma viagem rara", PÚBLICO, 2020, https://www.publico. pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Thesis / Dissertation
  1. Barros, Inês. "Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease". Master, Universidade de Coimbra Faculdade de Farmácia, 2019.

Artistic / Performance

Artistic exhibition
  1. Photograph exhibition - Brain flows for the Flawless. 2023.
  2. Exhibition “(Less) Plastic Brain” at UC Exploratório – Centro Ciênvia Viva de Coimbra (16 May – 18 June 2023). 2023.
Theatre play
  1. 2019. Viegas, Teresa Ana; Marques, Andreia; Santos, Bárbara; Henriques, Carina S.; Rufino-Ramos, David; Lobo, Diana Duarte; Alfaiate, Inês; et al. Holy CIBB.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/07 Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Spinocerebellar Ataxia Type 3. 54ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Universidade Nova (Coimbra, Portugal)
2023/03/17 Understanding the Mechanisms of Blood-Brain Barrier Dysregulation in Machado-Joseph Disease Congresso Anual SPDMov 2023
(Coimbra, Portugal)
2023/02/01 Mesenchymal Stromal Cells Alleviate Autophagy and Mitochondria Dynamics Alterations In Machado-Joseph Disease Models 53ª Reunião da Sociedade Portuguesa de Farmacologia (SPF)
Faculdade de Medicina da Universidade de Coimbra (Coimbra, Portugal)
2022/02/09 Assessing The Potential Of Mesenchymal Stromal Cells For Alleviation Of Blood-Brain Barrier Dysfunction In Machado-Joseph Disease 52ª reunião da Sociedade Portuguesa de Farmacologia - SPF 2022
Sociedade Portuguesa de Farmacologia (Porto)
2021/06/09 Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI)
European Society of Clinical Investigation (ESCI) (Online Event )
2020/10/14 Blood-brain barrier disruption in Machado-Joseph disease/spinocerebellar ataxia type 3: clinical and therapeutic implications CIBB Neuroscience and Disease thematic Line, Joint Data-Clubs
Centre for Innovative Biomedicine and Biotechnology (CIBB) (Online Event, Portugal)
2019/12/19 MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go? Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting
Center for Innovative Biomedicine and Biotechnology (Coimbra, Portugal)
2019/10/10 Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019/05/22 Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI)
European Society for Clinical Investigation (Coimbra, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/02/29 - 2024/02/29 Less Rare: Demystifying Rare Disorders Round table and a dance performance. (2024/02/29 - 2024/02/29)
Round table (Co-organisor)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

UC Exploratório – Centro Ciênvia Viva de Coimbra , Portugal
2022 - 2023 Webinar series "Breaking down the Ivory Tower" webinar series organized by the working group Increasing Accessibility of ALBA Network (2022)
Seminar (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/05/13 - 2023/05/13 Informative Quiz activity, as part of the “Coimbra. Circular 23”, under the theme (Less)PlasticBrain (13 May 2023).
Festival
 Coimbra. Circular 23
2022/10/16 - 2022/10/16 Scientific divulgation related activities, as part of the Festival Internacional de Ciência 2022, under the theme Less Rare: Promovendo o Conhecimento da Doença de Machado-Joseph através da ARTE, da CIÊNCIA e da EDUCAÇÃO Dance performance about Machado-Joseph disease O cérebro a Caminho da Perfeição
Festival
 Festival Internacional de Ciência 2022
2022/10/10 - 2022/10/10 Scientific divulgation related activities, as part of the Festival Internacional de Ciência 2022, under the theme (Less)PlasticBrain. Development of Puzzles and Quiz for children
Festival
 Festival Internacional de Ciência
2022/09/30 - 2022/09/30 Scientific divulgation related activities, as part of the Noite Europeia dos Investigadores, under the theme Less Rare: Promovendo o Conhecimento da Doença de Machado-Joseph através da ARTE, da CIÊNCIA e da EDUCAÇÃO Dance performance about Machado-Joseph disease O cérebro a Caminho da Perfeição, vídeo Pessoas Raras movendo corações and public event Raro merece ser reconhecido
Other
 Noite Europeia dos Investigadores 2022

Association member

Society Organization name Role
2023 - Current Portuguese Society for Stem Cells and Cellular Therapy (SPCE-TC)
2023 - Current Portuguese Society of Neuroscience (SPN)
2022 - Current European Society of Gene and Cell Therapy (ESCGT)

Mentoring / Tutoring

Topic Student name
2023/09 - 2024/09 Glioma-to-neuron Reprogramming as a Technology for Escaping Glioma Proliferation Brenda Fernandes Dias
2023/09 - 2024/09 Reprogramming Astrocytes into Healthy Neurons to Treat Machado-JosephDisease/Spinocerebellar Ataxia Type-3 Vanessa Silva Santos
2021/09 - 2022/07 Mesenchymal Stromal Cells as a Therapy for Machado-Joseph Disease Implications in Mitochondrial Dysfunction and Quality Control Pathways António Silva
2020/10 - 2021/10 Evaluating the Potential of Mesenchymal Stromal Cells in the Alleviation of Blood-Brain Barrier Impairments in Machado-Joseph Disease. Daniela Gonzaga
Distinctions

Award

2022 Conference Fellowship Award
2019 PhD individual scholarship from FCT (SFRH/ BD / 148877/2019)
Fundação para a Ciência e a Tecnologia, Portugal
2016 Prémio 3% dos Melhores Estudantes / 3% Best Students Award
Universidade de Coimbra, Portugal