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Senior Group Leader: Polarity Division Morphogenesis team, Genetics and Developmental Biology Unit, CNRS U3215 INSERM U934 Curie Institute, Paris (France).
Identification

Personal identification

Full name
BELLAICHE Yohanns

Citation names

  • BELLAICHE, Yohanns

Author identifiers

Ciência ID
1911-BBC1-6E9D
ORCID iD
0000-0003-1686-2943

Websites

  • https://science.institut-curie.org/research/biology-cancer-genetics-and-epigenetics/developmental-biology-and-genetics/team-bellaiche/ (Professional)
Education
Degree Classification
1995 - 1998/07/10
Concluded
PhD thesis in the lab of N. Perrimon, Harvard Medical School, Boston. USA (Docteur)
Major in PhD thesis in the lab of N. Perrimon, Harvard Medical School, Boston. USA
Sorbonne Université UFR de Biologie, France
1995/07/01
Concluded
Master (DEA)
École Normale Supérieure, France

Sorbonne Université Campus Pierre et Marie Curie, France
Affiliation

Science

Category
Host institution
Employer
2019 - Current Coordinating Researcher (Research) Institut Curie, France
2003/10/01 - Current Principal Investigator (Research) Centre National de la Recherche Scientifique, France
1998 - 2003 Postdoc (Research) École Normale Supérieure, France
École Normale Supérieure, France

Positions / Appointments

Category
Host institution
Employer
2025 - Current Organic Unit Director Institut Curie, France
Génétique et Biologie du Développement, France
2003/10/01 - Current Manager of Laboratory, Institute, Museum, Centre or Observatory Centre National de la Recherche Scientifique, France
Institut Curie Centre de Recherche, France
2011/01/01 - 2024 Organic Unit Sub-director Institut Curie Centre de Recherche, France
Institut Curie Centre de Recherche, France
Outputs

Publications

Journal article
  1. Margarida Gonçalves; Catarina Lopes; Hervé Alégot; Mariana Osswald; Floris Bosveld; Carolina Ramos; Graziella Richard; et al. "The Dystrophin-Dystroglycan complex ensures cytokinesis efficiency in Drosophila epithelia". EMBO Reports (2024): https://doi.org/10.1038/s44319-024-00319-y.
    10.1038/s44319-024-00319-y
  2. Mélanie Gracia; Bénédicte M. Lefèvre; Raquel Güell Alonso; Victoire Cachoux; Maria Balakireva; Boris Guirao; Damien Cuvelier; Allison J. Bardin; Yohanns Bellaïche. "Applying mechanical forces on Drosophila tissues in vivo using the StretchCo, a 3D-printable device". STAR Protocols (2024): https://doi.org/10.1016/j.xpro.2024.102851.
    10.1016/j.xpro.2024.102851
  3. Long Li; Na Zhang; Seyed Amir Hamze Beati; Jose De las heras chanes; Florencia di Pietro; Yohanns Bellaiche; Hans-Arno J. Müller; Jörg Großhans. "Kinesin-1 patterns Par-1 and Rho signaling at the cortex of syncytial embryos of Drosophila". Journal of Cell Biology (2024): https://doi.org/10.1083/jcb.202206013.
    10.1083/jcb.202206013
  4. Cachoux, Victoire M.L.; Balakireva, Maria; Gracia, Mélanie; Bosveld, Floris; López-Gay, Jesús M.; Maugarny, Aude; Gaugué, Isabelle; et al. "Epithelial apoptotic pattern emerges from global and local regulation by cell apical area". Current Biology 33 22 (2023): 4807-4826.e6. https://doi.org/10.1016/j.cub.2023.09.049.
    10.1016/j.cub.2023.09.049
  5. di Pietro, Florencia; Osswald, Mariana; De las Heras, José M.; Cristo, Inês; López-Gay, Jesús; Wang, Zhimin; Pelletier, Stéphane; et al. "Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division". Current Biology 33 5 (2023): 858-874.e7. https://doi.org/10.1016/j.cub.2023.01.028.
    10.1016/j.cub.2023.01.028
  6. Aurélien Villedieu; Lale Alpar; Isabelle Gaugué; Amina Joudat; François Graner; Floris Bosveld; Yohanns Bellaïche. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics". Nature Communications (2023): https://doi.org/10.1038/s41467-023-36305-6.
    10.1038/s41467-023-36305-6
  7. di Pietro, Florencia; Herszterg, Sophie; Huang, Anqi; Bosveld, Floris; Alexandre, Cyrille; Sancéré, Lucas; Pelletier, Stéphane; et al. "Rapid and robust optogenetic control of gene expression in Drosophila". Developmental Cell 56 24 (2021): 3393-3404.e7. https://doi.org/10.1016/j.devcel.2021.11.016.
    10.1016/j.devcel.2021.11.016
  8. López-Gay, Jesús M.; Nunley, Hayden; Spencer, Meryl; di Pietro, Florencia; Guirao, Boris; Bosveld, Floris; Markova, Olga; et al. "Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue". Science 370 6514 (2020): eabb2169. http://dx.doi.org/10.1126/science.abb2169.
    10.1126/science.abb2169
  9. Yu, Joyce J.S.; Maugarny-Calès, Aude; Pelletier, Stéphane; Alexandre, Cyrille; Bellaiche, Yohanns; Vincent, Jean-Paul; McGough, Ian J.. "Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands". Developmental Cell 54 5 (2020): 583-592.e5. http://dx.doi.org/10.1016/j.devcel.2020.08.004.
    10.1016/j.devcel.2020.08.004
  10. Villedieu, Aurélien; Bosveld, Floris; Bellaïche, Yohanns. "Mechanical induction and competence in epithelial morphogenesis". Current Opinion in Genetics & Development 63 (2020): 36-44. http://dx.doi.org/10.1016/j.gde.2020.03.003.
    10.1016/j.gde.2020.03.003
  11. Bosveld, F; Bellaïche, Y. "Tricellular junctions". Current Biology 30 6 (2020): R249-R251. http://dx.doi.org/10.1016/j.cub.2020.01.029.
    10.1016/j.cub.2020.01.029
  12. van Leen, EV; di Pietro, F; Bellaïche, Y. "Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices". Current Opinion in Cell Biology 62 (2020): 9-16. http://dx.doi.org/10.1016/j.ceb.2019.07.013.
    10.1016/j.ceb.2019.07.013
  13. Edwards-Jorquera, SS; Bosveld, F; Bellaïche, Y; Lennon-Duménil, A-M; Glavic, Á. "Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages". The Journal of Cell Biology 219 3 (2020): http://dx.doi.org/10.1083/jcb.201905228.
    10.1083/jcb.201905228
  14. Goshima, G; Bellaïche, Y. "Editorial overview: Cell division – from molecules to tissues". Current Opinion in Cell Biology 60 (2019): iii-v. http://dx.doi.org/10.1016/j.ceb.2019.06.006.
    10.1016/j.ceb.2019.06.006
  15. Krndija, D; El Marjou, F; Guirao, B; Richon, S; Leroy, O; Bellaiche, Y; Hannezo, E; Matic Vignjevic, D. "Active cell migration is critical for steady-state epithelial turnover in the gut". Science 365 6454 (2019): 705-710. http://dx.doi.org/10.1126/science.aau3429.
    10.1126/science.aau3429
  16. Edwards, SS; Delgado, MG; Nader, GPF; Piel, M; Bellaiche, Y; Lennon-Duménil, A-M; Glavic, Á. "An in vitro method for studying subcellular rearrangements during cell polarization in Drosophila melanogaster hemocytes". Mechanisms of Development 154 (2018): 277-286. http://dx.doi.org/10.1016/j.mod.2018.08.003.
    10.1016/j.mod.2018.08.003
  17. Pinheiro, D; Bellaïche, Y. "Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics". Developmental Cell 47 1 (2018): 3-19. http://dx.doi.org/10.1016/j.devcel.2018.09.014.
    10.1016/j.devcel.2018.09.014
  18. di Pietro, F; Bellaïche, Y. "Actin Network Discussion during Mitotic Pseudo-Furrowing". Developmental Cell 45 5 (2018): 539-541. http://dx.doi.org/10.1016/j.devcel.2018.05.018.
    10.1016/j.devcel.2018.05.018
  19. Floris Bosveld; Zhimin Wang; Yohanns Bellaïche. "Tricellular junctions: a hot corner of epithelial biology". Current Opinion in Cell Biology (2018): https://hal.archives-ouvertes.fr/hal-02413129.
  20. Wang, Z; Bosveld, F; Bellaïche, Y. "Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis". Journal of Cell Science 131 11 (2018): jcs215764. http://dx.doi.org/10.1242/jcs.215764.
    10.1242/jcs.215764
  21. Guirao, B; Bellaïche, Y. "Biomechanics of cell rearrangements in Drosophila". Current Opinion in Cell Biology 48 (2017): 113-124. http://dx.doi.org/10.1016/j.ceb.2017.06.004.
    10.1016/j.ceb.2017.06.004
  22. Bosveld, F; Ainslie, A; Bellaïche, Y. "Sequential activities of Dynein, Mud and Asp in centrosome–spindle coupling maintain centrosome number upon mitosis". Journal of Cell Science 130 20 (2017): 3557-3567. http://dx.doi.org/10.1242/jcs.201350.
    10.1242/jcs.201350
  23. Tissot, N; Lepesant, J-A; Bernard, F; Legent, K; Bosveld, F; Martin, C; Faklaris, O; et al. "Distinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyte". Nature Communications 8 1 (2017): http://dx.doi.org/10.1038/ncomms15168.
    10.1038/ncomms15168
  24. Pinheiro, D; Hannezo, E; Herszterg, S; Bosveld, F; Gaugue, I; Balakireva, M; Wang, Z; et al. "Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows". Nature 545 7652 (2017): 103-107. http://dx.doi.org/10.1038/nature22041.
    10.1038/nature22041
  25. Park, S; Gonzalez, D; Guirao, B; Boucher, JD; Cockburn, K; Marsh, ED; Mesa, KR; et al. "Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice". Nature Cell Biology 19 3 (2017): 155-163. http://dx.doi.org/10.1038/ncb3472.
    10.1038/ncb3472
  26. Bellaïche, Y. "Cell Division in the Light of Modeling". Developmental Cell 38 6 (2016): 584-586. http://dx.doi.org/10.1016/j.devcel.2016.09.008.
    10.1016/j.devcel.2016.09.008
  27. Bosveld F; Markova O; Guirao B; Martin C; Wang Z; Pierre A; Balakireva M; et al. "Erratum: Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis.". (2016): http://europepmc.org/abstract/med/26982720.
    10.1038/nature17622
  28. Bosveld F; Markova O; Guirao B; Martin C; Wang Z; Pierre A; Balakireva M; et al. "Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis.". (2016): http://europepmc.org/abstract/med/26886796.
    10.1038/nature16970
  29. Bosveld F; Guirao B; Wang Z; Rivière M; Bonnet I; Graner F; Bellaïche Y. "Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts.". (2016): http://europepmc.org/abstract/med/26811379.
    10.1242/dev.127993
  30. Martín-Bermudo MD; Bardet PL; Bellaïche Y; Malartre M. "The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development.". (2015): http://europepmc.org/abstract/med/25813543.
    10.1242/dev.110585
  31. Guirao B; Rigaud SU; Bosveld F; Bailles A; López-Gay J; Ishihara S; Sugimura K; Graner F; Bellaïche Y. "Unified quantitative characterization of epithelial tissue development.". (2015): http://europepmc.org/abstract/med/26653285.
    10.7554/eLife.08519
  32. Herszterg S; Pinheiro D; Bellaïche Y. "A multicellular view of cytokinesis in epithelial tissue.". (2014): http://europepmc.org/abstract/med/24380642.
    10.1016/j.tcb.2013.11.009
  33. Pinheiro D; Bellaïche Y. "Making the most of the midbody remnant: specification of the dorsal-ventral axis.". (2014): http://europepmc.org/abstract/med/24525182.
    10.1016/j.devcel.2014.01.026
  34. Bouissou A; Vérollet C; de Forges H; Haren L; Bellaïche Y; Perez F; Merdes A; Raynaud-Messina B. "¿-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning.". (2014): http://europepmc.org/abstract/med/24421324.
    10.1002/embj.201385967
  35. Bardet PL; Guirao B; Paoletti C; Serman F; Léopold V; Bosveld F; Goya Y; et al. "PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue.". (2013): http://europepmc.org/abstract/med/23707736.
    10.1016/j.devcel.2013.04.020
  36. Heisenberg CP; Bellaïche Y. "Forces in tissue morphogenesis and patterning.". (2013): http://europepmc.org/abstract/med/23706734.
    10.1016/j.cell.2013.05.008
  37. Ishihara S; Sugimura K; Cox SJ; Bonnet I; Bellaïche Y; Graner F. "Comparative study of non-invasive force and stress inference methods in tissue.". (2013): http://europepmc.org/abstract/med/23615875.
    10.1140/epje/i2013-13045-8
  38. Herszterg, Sophie; Leibfried, Andrea; Bosveld, Floris; Martin, Charlotte; Bellaiche, Yohanns. "Interplay between the Dividing Cell and Its Neighbors Regulates Adherens Junction Formation during Cytokinesis in Epithelial Tissue". Developmental Cell 24 3 (2013): 256-270. https://doi.org/10.1016/j.devcel.2012.11.019.
    10.1016/j.devcel.2012.11.019
  39. Sugimura K; Bellaïche Y; Graner F; Marcq P; Ishihara S. "Robustness of force and stress inference in an epithelial tissue.". (2013): http://europepmc.org/abstract/med/24110287.
    10.1109/EMBC.2013.6610100
  40. Bonnet I; Marcq P; Bosveld F; Fetler L; Bellaïche Y; Graner F. "Mechanical state, material properties and continuous description of an epithelial tissue.". (2012): http://europepmc.org/abstract/med/22628216.
    10.1098/rsif.2012.0263
  41. Bosveld F; Bonnet I; Guirao B; Tlili S; Wang Z; Petitalot A; Marchand R; et al. "Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway.". (2012): http://europepmc.org/abstract/med/22499807.
    10.1126/science.1221071
  42. Morin X; Bellaïche Y. "Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development.". (2011): http://europepmc.org/abstract/med/21763612.
    10.1016/j.devcel.2011.06.012
  43. Bellaïche Y; Bosveld F; Graner F; Mikula K; Remesíková M; Smísek M. "New robust algorithm for tracking cells in videos of Drosophila morphogenesis based on finding an ideal path in segmented spatio-temporal cellular structures.". (2011): http://europepmc.org/abstract/med/22255854.
    10.1109/IEMBS.2011.6091630
  44. Ségalen M; Johnston CA; Martin CA; Dumortier JG; Prehoda KE; David NB; Doe CQ; Bellaïche Y. "The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish.". (2010): http://europepmc.org/abstract/med/21074723.
    10.1016/j.devcel.2010.10.004
  45. Segalen M; Bellaïche Y. "Cell division orientation and planar cell polarity pathways.". (2009): http://europepmc.org/abstract/med/19447051.
    10.1016/j.semcdb.2009.03.018
  46. Bellaïche Y; Munro E. "Pushing the frontiers of development.". (2009): http://europepmc.org/abstract/med/19103801.
    10.1242/dev.028407
  47. Leibfried A; Bellaïche Y. "Functions of endosomal trafficking in Drosophila epithelial cells.". (2007): http://europepmc.org/abstract/med/17651956.
    10.1016/j.ceb.2007.06.004
  48. Sébastien Courty; Camilla Luccardini; Yohanns Bellaiche; Giovanni Cappello; Maxime Dahan. "Tracking individual kinesin motors in living cells using single quantum-dot imaging.". Nano Letters (2006): https://hal.archives-ouvertes.fr/hal-01138978.
  49. Ségalen M; David N; Bellaïche Y. "[The heterotrimeric G proteins during asymmetric cell division in Drosophila].". (2006): http://europepmc.org/abstract/med/16527201.
    10.1051/medsci/2006223243
  50. David NB; Martin CA; Segalen M; Rosenfeld F; Schweisguth F; Bellaïche Y. "Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division.". (2005): http://europepmc.org/abstract/med/16228010.
    10.1038/ncb1319
  51. Langevin J; Morgan MJ; Sibarita JB; Aresta S; Murthy M; Schwarz T; Camonis J; Bellaïche Y. "Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.". (2005): http://europepmc.org/abstract/med/16224820.
    10.1016/j.devcel.2005.07.013
  52. Langevin J; Le Borgne R; Rosenfeld F; Gho M; Schweisguth F; Bellaïche Y. "Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells.". (2005): http://europepmc.org/abstract/med/15916953.
    10.1016/j.cub.2005.04.054
  53. Orgogozo V; Schweisguth F; Bellaïche Y. "Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila.". (2004): http://europepmc.org/abstract/med/15147761.
    10.1016/j.mod.2004.04.001
  54. Bellaïche Y; Beaudoin-Massiani O; Stuttem I; Schweisguth F. "The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila.". (2004): http://europepmc.org/abstract/med/14701683.
    10.1242/dev.00928
  55. Orgogozo V; Schweisguth F; Bellaïche Y. "Binary cell death decision regulated by unequal partitioning of Numb at mitosis.". (2002): http://europepmc.org/abstract/med/12361960.
  56. Le Borgne R; Bellaïche Y; Schweisguth F. "Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage.". (2002): http://europepmc.org/abstract/med/11818059.
    10.1016/S0960-9822(01)00648-0
  57. Bellaïche Y; Schweisguth F. "Lineage diversity in the Drosophila nervous system.". (2001): http://europepmc.org/abstract/med/11448628.
    10.1016/S0959-437X(00)00212-4
  58. Bellaïche Y; Radovic A; Woods DF; Hough CD; Parmentier ML; O'Kane CJ; Bryant PJ; Schweisguth F. "The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila.". (2001): http://europepmc.org/abstract/med/11509184.
    10.1016/S0092-8674(01)00444-5
  59. Orgogozo V; Schweisguth F; Bellaïche Y. "Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo.". (2001): http://europepmc.org/abstract/med/11171389.
  60. Bellaïche Y; Gho M; Kaltschmidt JA; Brand AH; Schweisguth F. "Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division.". (2001): http://europepmc.org/abstract/med/11146626.
    10.1038/35050558
  61. Gho M; Bellaïche Y; Schweisguth F. "Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell.". (1999): http://europepmc.org/abstract/med/10409503.
  62. Bellaiche, Yohanns; The, Inge; Perrimon, Norbert. "Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion". Nature 394 6688 (1998): 85-88. https://doi.org/10.1038/27932.
    10.1038/27932
  63. Bellaïche Y; Bandyopadhyay R; Desplan C; Dostatni N. "Neither the homeodomain nor the activation domain of Bicoid is specifically required for its down-regulation by the Torso receptor tyrosine kinase cascade.". (1996): http://europepmc.org/abstract/med/8951065.
Preprint
  1. Olivier Leroy; Eric van Leen; Philippe Girard; Aurélien Villedieu; Christian Hubert; Floris Bosveld; Yohanns Bellaïche; Olivier Renaud. "Multi-view confocal microscopy enables multiple organ and whole organism live-imaging". 2021. https://doi.org/10.1101/2021.05.04.442565.
    10.1101/2021.05.04.442565
Distinctions

Award

2020 ERC Advanced Grant
European Research Council, Belgium
2019 Beaufort Visiting Scholar
University of Cambridge, United Kingdom
2019 ERC Proof of Concept Grant
European Research Council, Belgium
2018 Richard Lounsbery Prize, Lounsbery Foundation, French and American Science Academies
2013 ERC Advanced Grant
European Research Council, Belgium
2012 EMBO Member
2007 ERC Starting Grant
European Research Council, Belgium
2005 EMBO Young Investigator
2003 CNRS Bronze Medal, CNRS
2002 Paoletti Award, CNRS