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Identification

Personal identification

Full name
Pedro Miguel Araújo Campos de Castro

Citation names

  • Castro, Pedro

Author identifiers

Ciência ID
1912-0FBC-BBCA
ORCID iD
0000-0003-1401-2398
Researcher Id
L-3779-2014
Scopus Author Id
57205452138
Education
Degree Classification
2010/09/08 - 2017/09/12
Concluded
 Doutoramento em Medicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Hemodinâmica e doença vascular cerebrais evolução e factor prognóstico da autorregulação dinâmica do fluxo sanguíneo cerebral no acidente vascular cerebral agudo" (THESIS/DISSERTATION)
 Aprovado com distinção
2008/02/01 - 2013/05/23
Concluded
 Neurologista (Título de especialista)
Centro Hospitalar Universitário de São João, Portugal
 18
2000/09/01 - 2006/06/30
Concluded
 Medicina (Licenciatura)
Major in Médica
Universidade do Porto Faculdade de Medicina, Portugal
 17
Projects

Grant

Designation Funders
2008/02 - 2012/02 Cerebral Autoregulation in Acute Stroke"; Project supported by Portugues
PTDC/SAU-ORG/113329/2009
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Outputs

Publications

Book chapter
  1. Azevedo, E.I.; Castro, P.M.. "Novel applications of ultrasound vascular imaging". 33-66. 2013.
Conference paper
  1. Henriques, H.A.M.; Sousa, L.C.; Castro, C.F.; António, C.C.; Santos, R.; Castro, P.; Azevedo, E.. "Blood flow in the common carotid artery with stenosis". 2016.
    10.7712/100016.1795.9043
  2. Sousa, L.C.; Castro, C.F.; António, C.C.; Chaves, R.; Santos, R.; Castro, P.; Azevedo, E.. "Hemodynamics of a stenosed carotid bifurcation". 2013.
Journal article
  1. Lucy Beishon; Terrie Vasilopoulos; Angela S.M. Salinet; Brooke Levis; Samuel Barnes; Eleanor Hills; Pranav Ramesh; et al. "Individual Patient Data Meta-Analysis of Dynamic Cerebral Autoregulation and Functional Outcome After Ischemic Stroke". Stroke (2024): https://doi.org/10.1161/STROKEAHA.123.045700.
    10.1161/STROKEAHA.123.045700
  2. Juliana Ferreira; Patrícia Ferreira; Elsa Azevedo; Pedro Castro. "Assessment of Neurovascular Coupling by Spectral Analysis of Cerebral Blood Flow Velocity With Transcranial Doppler". Ultrasound in Medicine & Biology (2024): https://doi.org/10.1016/j.ultrasmedbio.2024.02.003.
    10.1016/j.ultrasmedbio.2024.02.003
  3. Pedro Castro; J Ferreira; Branko Malojcic; Danira Bazadona; Claudio Baracchini; Alessio Pieroni; David Skoloudik; Elsa Azevedo; Manfred Kaps. "Detection of microemboli in patients with acute ischaemic stroke and atrial fibrillation suggests poor functional outcome". European Stroke Journal (2023): https://doi.org/10.1177/23969873231220508.
    10.1177/23969873231220508
  4. Ronney B Panerai; Patrice Brassard; Joel S Burma; Pedro Castro; Jurgen AHR Claassen; Johannes J van Lieshout; Jia Liu; et al. "Transfer function analysis of dynamic cerebral autoregulation: A CARNet white paper 2022 update". Journal of Cerebral Blood Flow & Metabolism (2023): https://doi.org/10.1177/0271678X221119760.
    10.1177/0271678X221119760
  5. Pedro Castro; João Freitas; Elsa Azevedo; Can Ozan Tan. "Cerebrovascular regulation in patients with vasovagal syncope and autonomic failure due to familial amyloidotic polyneuropathy". Autonomic Neuroscience (2022): https://doi.org/10.1016/j.autneu.2022.103010.
    10.1016/j.autneu.2022.103010
  6. Ricardo C Nogueira; Marcel Aries; Jatinder S Minhas; Nils H Petersen; Li Xiong; Jana M Kainerstorfer; Pedro Castro. "Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome". Journal of Cerebral Blood Flow & Metabolism (2022): 0271678X2110452-0271678X2110452. https://doi.org/10.1177/0271678X211045222.
    10.1177/0271678X211045222
  7. Dória, H.M.; Videira, G.; Ferreira, D.; Castro, P.; Albuquerque, L.; Filipe, J.P.; Felgueiras, R.; et al. "Posterior Circulation Stroke: Coma (More Than Time) is Brain". Journal of Stroke and Cerebrovascular Diseases 31 4 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123626874&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2022.106313
  8. Correia, M.; Silva, I.; Gabriel, D.; Simrén, J.; Carneiro, A.; Ribeiro, S.; Dória, H.M.; et al. "Early plasma biomarker dynamic profiles are associated with acute ischemic stroke outcomes". European Journal of Neurology (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85124878832&partnerID=MN8TOARS.
    10.1111/ene.15273
  9. Marto, J.P.; Kauppila, L.A.; Jorge, C.; Faustino, P.; Sargento-Freitas, J.; Pereira, L.; Galego, S.; et al. "Acute Myocardial Infarction after Intravenous Thrombolysis for Acute Ischemic Stroke: Case Series and Systematic Review". Journal of Stroke and Cerebrovascular Diseases 31 2 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120956360&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2021.106244
  10. Pedro Castro; Francisca Ferreira; Cindy K. Nguyen; Seyedmehdi Payabvash; Can Ozan Tan; Farzaneh Sorond; Elsa Azevedo; Nils Petersen. "Rapid Assessment of Blood Pressure Variability and Outcome After Successful Thrombectomy". Stroke 52 9 (2021): https://doi.org/10.1161/STROKEAHA.121.034291.
    10.1161/STROKEAHA.121.034291
  11. Leonor Dias; Maria João Pinto; Pedro Castro; Marta Carvalho. "Inflammatory Biomarkers Correlate with Time Evolution in Cerebral Venous Thrombosis". Journal of Stroke and Cerebrovascular Diseases 30 7 (2021): 105844-105844. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105844.
    10.1016/j.jstrokecerebrovasdis.2021.105844
  12. Daniela Ferro; Margarida Matias; Joana Neto; Rafael Dias; Goreti Moreira; Nils Petersen; Elsa Azevedo; Pedro Castro. "Neutrophil-to-Lymphocyte Ratio Predicts Cerebral Edema and Clinical Worsening Early After Reperfusion Therapy in Stroke". Stroke 52 3 (2021): 859-867. https://doi.org/10.1161/STROKEAHA.120.032130.
    10.1161/STROKEAHA.120.032130
  13. Dias, R.A.; Dias, L.; Azevedo, E.; Castro, P.. "Acute inflammation in cerebrovascular disease: A critical reappraisal with focus on human studies". Life 11 10 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85118182581&partnerID=MN8TOARS.
    10.3390/life11101103
  14. Soares, C.; Costa, A.; Santos, R.; Abreu, P.; Castro, P.; Azevedo, E.. "Clinical, Laboratory and Ultrasonographic Interrelations in Giant Cell Arteritis". Journal of Stroke and Cerebrovascular Diseases 30 4 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099855958&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2021.105601
  15. Monteiro, A.; Castro, P.; Pereira, G.; Ferreira, C.; Sorond, F.; Milstead, A.; Higgins, J.P.; Polónia, J.; Azevedo, E.. "Neurovascular Coupling Is Impaired in Hypertensive and Diabetic Subjects Without Symptomatic Cerebrovascular Disease". Frontiers in Aging Neuroscience 13 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85117502771&partnerID=MN8TOARS.
    10.3389/fnagi.2021.728007
  16. Pedro Castro; Jorge Serrador; Isabel Rocha; Paulo Castro Chaves; Farzaneh Sorond; Elsa Azevedo. "Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke". Journal of Thrombosis and Thrombolysis 50 3 (2020): 753-761. https://doi.org/10.1007/s11239-020-02166-9.
    10.1007/s11239-020-02166-9
  17. Faheem Sheriff; Pedro Castro; Mariel Kozberg; Sarah LaRose; Andrew Monk; Elsa Azevedo; Karen Li; et al. "Dynamic Cerebral Autoregulation Post Endovascular Thrombectomy in Acute Ischemic Stroke". Brain Sciences (2020): https://doi.org/10.3390/brainsci10090641.
    10.3390/brainsci10090641
  18. "Acute phase treatment in central retinal artery occlusion: thrombolysis, hyperbaric oxygen therapy or both?". Journal of Thrombosis and Thrombolysis (2020): http://dx.doi.org/10.1007/s11239-020-02072-0.
    10.1007/s11239-020-02072-0
  19. Beatriz Ferraz; Ricardo Reis; Ana Luísa Carvalho Rocha; Goreti Moreira; Luísa Fonseca; Tiago Parreira; Elsa Azevedo; Pedro Castro. "Prognostic yield of imaging before and after recanalization treatments in ischemic stroke". Acta Neurologica Scandinavica (2020): https://doi.org/10.1111/ane.13208.
    10.1111/ane.13208
  20. L Beishon; JS Minhas; R Nogueira; P Castro; C Budgeon; M Aries; S Payne; TG Robinson; RB Panerai. "INFOMATAS multi-center systematic review and meta-analysis individual patient data of dynamic cerebral autoregulation in ischemic stroke". International Journal of Stroke (2020): https://doi.org/10.1177/1747493020907003.
    10.1177/1747493020907003
  21. Sérgio Fonseca; Francisca Costa; Mafalda Seabra; Rafael Dias; Adriana Soares; Celeste Dias; Elsa Azevedo; Pedro Castro. "Systemic inflammation status at admission affects the outcome of intracerebral hemorrhage by increasing perihematomal edema but not the hematoma growth". Acta Neurologica Belgica (2020): https://doi.org/10.1007/s13760-019-01269-2.
    10.1007/s13760-019-01269-2
  22. "Microemboli After Successful Thrombectomy Do Not Affect Outcome but Predict New Embolic Events". Stroke (2020): http://dx.doi.org/10.1161/strokeaha.119.025856.
    10.1161/strokeaha.119.025856
  23. Das, A.S.; Regenhardt, R.W.; LaRose, S.; Monk, A.D.; Castro, P.M.; Sheriff, F.G.; Sorond, F.A.; Vaitkevicius, H.. "Microembolic Signals Detected by Transcranial Doppler Predict Future Stroke and Poor Outcomes". Journal of Neuroimaging 30 6 (2020): 882-889. http://www.scopus.com/inward/record.url?eid=2-s2.0-85087686908&partnerID=MN8TOARS.
    10.1111/jon.12749
  24. Castro, P.; Gutierres, M.; Pereira, G.; Ferreira, S.; Oliveira, J.P.; Azevedo, E.. "Evaluation of cerebral microvascular regulatory mechanisms with transcranial doppler in fabry disease". Brain Sciences 10 8 (2020): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090637375&partnerID=MN8TOARS.
    10.3390/brainsci10080528
  25. Aires, A.; Andrade, A.; Azevedo, E.; Gomes, F.; Araújo, J.P.; Castro, P.. "Neurovascular coupling impairment in heart failure with reduction ejection fraction". Brain Sciences 10 10 (2020): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092392944&partnerID=MN8TOARS.
    10.3390/brainsci10100714
  26. Andrea Jokumsen-Cabral; Ana Aires; Susana Ferreira; Elsa Azevedo; Pedro Castro. "Primary involvement of neurovascular coupling in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy". Journal of Neurology 266 7 (2019): 1782-1788. https://doi.org/10.1007/s00415-019-09331-y.
    10.1007/s00415-019-09331-y
  27. "Ageing affects the balance between central and peripheral mechanisms of cerebrovascular regulation with increasing influence of systolic blood pressure levels". European Journal of Applied Physiology (2019): http://dx.doi.org/10.1007/s00421-018-4036-3.
    10.1007/s00421-018-4036-3
  28. Pedro Castro; Elsa Azevedo; Isabel Rocha; Farzaneh Sorond; Jorge M. Serrador. "Chronic kidney disease and poor outcomes in ischemic stroke: is impaired cerebral autoregulation the missing link?". BMC Neurology 18 1 (2018): https://doi.org/10.1186/s12883-018-1025-4.
    10.1186/s12883-018-1025-4
  29. "Cerebral Autoregulation in Stroke". Current Atherosclerosis Reports (2018): http://dx.doi.org/10.1007/s11883-018-0739-5.
    10.1007/s11883-018-0739-5
  30. Fitas, D.; Carvalho, M.; Castro, P.; Abreu, P.; Moreira, G.; Santos, R.; Azevedo, E.. "Cerebral vasoconstriction after carotid endarterectomy". Practical Neurology 18 5 (2018): 378-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048358067&partnerID=MN8TOARS.
    10.1136/practneurol-2017-001871
  31. "Cerebral autoregulation is preserved in multiple sclerosis patients". Journal of the Neurological Sciences (2017): http://dx.doi.org/10.1016/j.jns.2017.09.009.
    10.1016/j.jns.2017.09.009
  32. Pedro Castro; João Freitas; Rosa Santos; Ronney Panerai; Elsa Azevedo. "Indexes of cerebral autoregulation do not reflect impairment in syncope: insights from head-up tilt test of vasovagal and autonomic failure subjects". European Journal of Applied Physiology (2017): https://doi.org/10.1007%2Fs00421-017-3674-1.
    10.1007/s00421-017-3674-1
  33. Castro, Pedro; Serrador, Jorge Manuel; Rocha, Isabel; Sorond, Farzaneh; Azevedo, Elsa. "Efficacy of cerebral autoregulation in early ischemic stroke predicts smaller infarcts and better outcome". (2017): http://hdl.handle.net/10451/39191.
    10.3389/fneur.2017.00113
  34. Madureira, J.; Castro, P.; Azevedo, E.. "Demographic and Systemic Hemodynamic Influences in Mechanisms of Cerebrovascular Regulation in Healthy Adults". Journal of Stroke and Cerebrovascular Diseases 26 3 (2017): 500-508. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009284678&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2016.12.003
  35. Santos, J.V.; Pereira, J.; Pinto, R.; Castro, P.M.; Azevedo, E.; Freitas, A.. "Atrial Fibrillation as an Ischemic Stroke Clinical and Economic Burden Modifier: A 15-Year Nationwide Study". Value in Health 20 8 (2017): 1083-1091. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021173805&partnerID=MN8TOARS.
    10.1016/j.jval.2017.04.018
  36. Monteiro, A.; Massano, J.; Leão, M.; Garrett, C.; Moura, C.; Azevedo, E.; Guimarães, J.; Oliveira, J.P.; Castro, P.. "Genetic study of primary dystonias: Recommendations from the centro hospitalar São João neurogenetics group,Estudo genético nas distonias primárias: Recomendações do grupo de neurogenética do centro hospitalar São João". Acta Medica Portuguesa 30 4 (2017): 340-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018370148&partnerID=MN8TOARS.
    10.20344/amp.8622
  37. Gomes, T.; Guimarães, J.; Leão, M.; Moura, C.; Garrett, C.; Azevedo, E.; Massano, J.; Castro, P.. "Investigation of genetic aetiology in neurodegenerative ataxias: Recommendations from the group of neurogenetics of centro hospitalar São João, Portugal,Investigação de etiologia genética nas ataxias neurodegenerativas: Recomendações do grupo de neurogenética do centro hospitalar São João, Portugal". Acta Medica Portuguesa 30 6 (2017): 502-512. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021828260&partnerID=MN8TOARS.
    10.20344/amp.8797
  38. Castro, P.; Azevedo, E.; Serrador, J.; Rocha, I.; Sorond, F.. "Hemorrhagic transformation and cerebral edema in acute ischemic stroke: Link to cerebral autoregulation". Journal of the Neurological Sciences 372 (2017): 256-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999287238&partnerID=MN8TOARS.
    10.1016/j.jns.2016.11.065
  39. Videira, G.; Castro, P.; Vieira, B.; Filipe, J.P.; Santos, R.; Azevedo, E.; Sá, M.J.; Abreu, P.. "Autonomic dysfunction in multiple sclerosis is better detected by heart rate variability and is not correlated with central autonomic network damage". Journal of the Neurological Sciences 367 (2016): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973442864&partnerID=MN8TOARS.
    10.1016/j.jns.2016.05.049
  40. Sousa, L.C.; Castro, C.F.; António, C.C.; Sousa, F.; Santos, R.; Castro, P.; Azevedo, E.. "Computational simulation of carotid stenosis and flow dynamics based on patient ultrasound data - A new tool for risk assessment and surgical planning". Advances in Medical Sciences 61 1 (2016): 32-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960081797&partnerID=MN8TOARS.
    10.1016/j.advms.2015.07.009
  41. Castro, P.; Costa, A.; Abreu, P.; Penas, S.; Faria, O.; Azevedo, E.. "Acute posterior multifocal placoid pigment epitheliopathy presenting with multiple brain and spinal cord infarctions". Journal of the Neurological Sciences 361 (2016): 26-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958976368&partnerID=MN8TOARS.
    10.1016/j.jns.2015.12.015
  42. Massano, J.; Leão, M.; Garrett, C.; Moura, C.; Azevedo, E.; Guimarães, J.; Oliveira, J.P.; Castro, P.. "Investigation of genetic etiology in neurodegenerative dementias: Recommendations from the centro hospitalar São João neurogenetics group,Investigação de etiologia genética nas demências neurodegenerativas: Recomendações do grupo de neurogenética do centro hospitalar São João". Acta Medica Portuguesa 29 10 (2016): 675-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994159031&partnerID=MN8TOARS.
    10.20344/amp.7583
  43. Castro, P.M.; Santos, R.; Freitas, J.; Panerai, R.B.; Azevedo, E.. "Autonomic dysfunction affects dynamic cerebral autoregulation during Valsalva maneuver: Comparison between healthy and autonomic dysfunction subjects". Journal of Applied Physiology 117 3 (2014): 205-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905439048&partnerID=MN8TOARS.
    10.1152/japplphysiol.00893.2013
  44. Sousa, L.C.; Castro, C.F.; António, C.C.; Santos, A.M.F.; dos Santos, R.M.; Castro, P.M.A.C.; Azevedo, E.; Tavares, J.M.R.S.. "Toward hemodynamic diagnosis of carotid artery stenosis based on ultrasound image data and computational modeling". Medical and Biological Engineering and Computing 52 11 (2014): 971-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911001774&partnerID=MN8TOARS.
    10.1007/s11517-014-1197-z
  45. Sousa, L.C.; Castro, C.F.; António, C.C.; Santos, A.; Santos, R.; Castro, P.; Azevedo, E.; Tavares, J.M.R.S.. "Haemodynamic conditions of patient-specific carotid bifurcation based on ultrasound imaging". Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization 2 3 (2014): 157-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981366275&partnerID=MN8TOARS.
    10.1080/21681163.2013.875486
  46. Santos, A.M.F.; Dos Santos, R.M.; Castro, P.M.A.C.; Azevedo, E.; Sousa, L.; Tavares, J.M.R.S.. "A novel automatic algorithm for the segmentation of the lumen of the carotid artery in ultrasound B-mode images". Expert Systems with Applications 40 16 (2013): 6570-6579. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880057031&partnerID=MN8TOARS.
    10.1016/j.eswa.2013.06.003
  47. Santos, A.M.F.; Tavares, J.M.R.S.; Sousa, L.; Santos, R.; Castro, P.; Azevedo, E.. "Automatic segmentation of the lumen of the carotid artery in ultrasound B-mode images". Proceedings of SPIE - The International Society for Optical Engineering 8670 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84878423245&partnerID=MN8TOARS.
    10.1117/12.2007259
  48. Azevedo, E.; Mendes, A.; Seixas, D.; Santos, R.; Castro, P.; Ayres-Basto, M.; Rosengarten, B.; Oliveira, J.P.. "Functional transcranial doppler: Presymptomatic changes in fabry disease". European Neurology 67 6 (2012): 331-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860855551&partnerID=MN8TOARS.
    10.1159/000337906
  49. Castro, P.; Santos, R.; Freitas, J.; Rosengarten, B.; Panerai, R.; Azevedoa, E.. "Adaptation of cerebral pressure-velocity hemodynamic changes of neurovascular coupling to orthostatic challenge". Perspectives in Medicine 1-12 (2012): 290-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867575698&partnerID=MN8TOARS.
    10.1016/j.permed.2012.02.052
  50. Castro, C.F.; Sousa, L.C.; Chaves, R.; António, C.C.; Santos, R.; Castro, P.; Azevedo, E.. "Mesh generation and blood flow simulation in human carotid bifurcation". Civil-Comp Proceedings 100 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893856677&partnerID=MN8TOARS.
  51. Azevedo, E.; Castro, P.; Santos, R.; Freitas, J.; Coelho, T.; Rosengarten, B.; Panerai, R.. "Autonomic dysfunction affects cerebral neurovascular coupling". Clinical Autonomic Research 21 6 (2011): 395-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-83155180523&partnerID=MN8TOARS.
    10.1007/s10286-011-0129-3
Distinctions

Award

2018 1º Prémio Comunicação Poster
Sociedade Portuguesa de AVC, Portugal
2017 1ºPrémio COMUNICACAÇÃO ORAL
Sociedade Portuguesa de AVC, Portugal