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Sandra Barata Antunes completed her MSc in Biomedical Science from the University of Beira Interior in 2016. Her MSc work consisted in the study of the role of histamine on the modulation of hippocampal inflammation and neurogenesis in adult mice, which resulted in 2 co-authored papers published in international peer-reviewed journals. Currently, she is a phD student (PhD programme in Applied Health Sciences) at Life and Health Sciences Research Institute (ICVS, School of Medicine, University of Minho) under the supervision of António Salgado. Her current research work is focused on the development of nanosystems for the delivery of cellular secretome in the context of Parkinson's Disease.
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Identification

Personal identification

Full name
Sandra Raquel Pinto Barata Antunes

Citation names

  • Barata-Antunes, Sandra

Author identifiers

Ciência ID
1A14-97A3-7FAB
ORCID iD
0000-0003-1858-4318

Telephones

Mobile phone
  • 917948879 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Engineering and Technology - Nano-technology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Advanced (C1) Advanced (C1) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/11 - 2021/11
Ongoing
 PhD student in FCT PhD programme in Applied Health Sciences (School of Medicine) (Doutoramento)
Universidade do Minho, Portugal
2014/09 - 2016/11
Concluded
 MSc in Biomedical Science (Mestrado)
Universidade da Beira Interior, Portugal
"Unveiling a novel crosstalk between histamine and lipopolysaccharide in the modulation of inflammation and neurogenesis in the hippocampus" (THESIS/DISSERTATION)
 17
2011/09 - 2014/07
Concluded
 BSc in Biomedical Sciences (Licenciatura)
Universidade da Beira Interior, Portugal
 14
2008/09 - 2011/07
Concluded
 Scientific-Humanistic Course of Science and Technology (Ensino secundário)
Didáxis Cooperativa de Ensino, Portugal
 18
Affiliation

Others

Category
Host institution 		Employer
2017/09 - Current PhD student Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho , Portugal
ICVS/3B’s – PT Government Associate Laboratory, Portugal
Projects

Contract

Designation Funders
2018/07/01 - 2021/12/31 Combinação do Secretoma de Células Estaminais Mesenquimatosas MSCs e terapias farmacológicas para o tratamento da Doença de Parkinson
PTDC/MED-FAR/29751/2017
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 Health Sciences Research Centre
UID/Multi/00709/2019
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Gomes, Eduardo D.; Barata-Antunes, Sandra; Teixeira-Castro, Andreia; Assunção-Silva, Rita C.; Marques, Cláudia R.; Monteiro, Susana; Teixeira, Fábio G.; Fernandes, Aline M.; Silva, Nuno A.. "Animal models of central nervous system disorders". In Handbook of Innovations in Central Nervous System Regenerative Medicine, 621-650. Elsevier, 2020.
    Published • 10.1016/b978-0-12-818084-6.00018-0
Conference poster
  1. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel; Barata-Antunes, Sandra; Lima, Rui; et al. "Modulation of Brain Connectivity, Structure, and Motor Function by Safinamide Multimodal Actions in a Pre-clinical Model of Parkinson’s Disease". Paper presented in 11th IBRO - World Congress of Neuroscience 2023, 2023.
  2. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel ; Barata-Antunes, Sandra; Rui Augusto Ribeiro Lima; et al. "Modulation of Brain Structure and Motor Function by Safinamide Multimodal Actions in a Pre-clinical Model of Parkinson’s Disease". Paper presented in FENS Regional Meeting 2023, 2023.
  3. Araújo, Bruna; Campos, Jonas; Domingues, Helena Sofia; Silva, Rita Caridade ; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel ; Barata-Antunes, Sandra; et al. "Addressing the Impact of Safinamide as a Parkinson's Disease Neuroprotective Drug". Paper presented in International conference on Alzheimer's and Parkinson's Disease and related neurological disorders (2022), 2022.
Journal article
  1. Ribeiro, Miguel; Campos, Jonas; Pinho, Tiffany S.; Sampaio-Marques, Belém; Barata-Antunes, Sandra; Cibrão, Jorge Ribeiro; Araújo, Ricardo; et al. "Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions". Biotechnology Journal 19 7 (2024): http://dx.doi.org/10.1002/biot.202400068.
    Published • 10.1002/biot.202400068
  2. Marques, Cláudia Raquel; Campos, Jonas; Sampaio-Marques, Belém; Antunes, Filipa Ferreira; dos Santos Cunha, Raquel Medina; Silva, Deolinda; Barata-Antunes, Sandra; et al. "Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an a-synuclein overexpression rat model". Cytotherapy 26 7 (2024): 700-713. http://dx.doi.org/10.1016/j.jcyt.2024.02.008.
    Published • 10.1016/j.jcyt.2024.02.008
  3. Pinho, Tiffany S.; Cibrão, Jorge Ribeiro; Silva, Deolinda; Barata-Antunes, Sandra; Campos, Jonas; Afonso, João L.; Sampaio-Marques, Belém; et al. "In vitro neuronal and glial response to magnetically stimulated piezoelectric poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)/cobalt ferrite (CFO) microspheres". Biomaterials Advances 159 (2024): 213798. http://dx.doi.org/10.1016/j.bioadv.2024.213798.
    Published • 10.1016/j.bioadv.2024.213798
  4. Mendes-Pinheiro, Bárbara; Campos, Jonas; Marote, Ana; Soares-Cunha, Carina; Nickels, Sarah L.; Monzel, Anna S.; Cibrão, Jorge R.; et al. "Treating Parkinson's Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration". Cells 12 21 (2023): 2565. http://dx.doi.org/10.3390/cells12212565.
    10.3390/cells12212565
  5. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Mendes-Pinheiro, Bárbara; Marques, Raquel; Barata, Sandra; Lima, Rui; et al. "MODULATION OF BRAIN CONNECTIVITY, STRUCTURE, NEURON AND GLIA, AND MOTOR FUNCTION BY SAFINAMIDE MULTIMODAL ACTIONS IN A PRE-CLINICAL MODEL OF PARKINSON’S DISEASE". IBRO Neuroscience Reports 15 (2023): S212. http://dx.doi.org/10.1016/j.ibneur.2023.08.337.
    10.1016/j.ibneur.2023.08.337
  6. Deolinda Silva; Lucas Schirmer; Tiffany S. Pinho; Passant Atallah; Jorge R. Cibrão; Rui Lima; João Afonso; et al. "Sustained Release of Human Adipose Tissue Stem Cell Secretome from Star-Shaped Poly(ethylene glycol) Glycosaminoglycan Hydrogels Promotes Motor Improvements after Complete Transection in Spinal Cord Injury Rat Model". Advanced Healthcare Materials (2023): https://doi.org/10.1002/adhm.202202803.
    10.1002/adhm.202202803
  7. Fernandes, Aline M.; Campos, Jonas; Silva, Deolinda; Barata Antunes, Sandra; Lima, Rui; Coelho, Claudio; Marote, Ana M.; et al. "Cerebral Organoids to Study Central Mechanisms of Pain: The Effect of Stem Cell Secretome on Opioid Receptors and Neuroplasticity". Stem Cells and Development 31 19-20 (2022): 641-657. http://dx.doi.org/10.1089/scd.2022.0116.
    Published • 10.1089/scd.2022.0116
  8. Bárbara Mendes-Pinheiro; Carina Soares-Cunha; Ana Marote; Eduardo Loureiro-Campos; Jonas Campos; Sandra Barata-Antunes; Daniela Monteiro-Fernandes; et al. "Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response". International Journal of Molecular Sciences 22 21 (2021): 11530-11530. https://doi.org/10.3390/ijms222111530.
    10.3390/ijms222111530
  9. Sandra Barata-Antunes; Fábio G. Teixeira; Bárbara Mendes-Pinheiro; Ana V. Domingues; Helena Vilaça-Faria; Ana Marote; Deolinda Silva; Rui A. Sousa; António J. Salgado. "Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease". International Journal of Molecular Sciences 21 10 (2020): 3459-3459. https://doi.org/10.3390/ijms21103459.
    10.3390/ijms21103459
  10. Antunes, Sandra. "Cell and Tissue Instructive Materials for Central Nervous System Repair". Advanced Functional Materials (2020): http://dx.doi.org/10.1002/adfm.201909083.
    10.1002/adfm.201909083
  11. Antunes, Sandra. "Histamine modulates hippocampal inflammation and neurogenesis in adult mice". Scientific Reports (2019): http://dx.doi.org/10.1038/s41598-019-44816-w.
    10.1038/s41598-019-44816-w
  12. Antunes, Sandra. "Dual role of histamine on microglia-induced neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2017): http://dx.doi.org/10.1016/j.bbadis.2016.12.016.
    10.1016/j.bbadis.2016.12.016
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/06/28 Podium presentation about "Developing brain-targeting liposomes to deliver mesenchymal stem cells secretome for Parkinson's Disease Regenerative Medicine" TERMIS European Chapter Conference 2022
Tissue Engineering and Regenerative Medicine International Society (TERMIS) (Kraków, Poland)
2021/12/02 Poster communication about "Developing ligand-functionalized liposomes to deliver mesenchymal stem cells secretome for Parkinson’s Disease Regenerative Medicine" on the XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal XVII Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Coimbra, Portugal)
2021/11/15 Poster communication about "Developing lipid-based nanoparticles for systemic delivery of mesenchymal stem cells secretome in Parkinson's disease Regenerative Medicine" on the 6TH TERMIS WORLD CONGRESS, Maastricht, Netherlands 6TH TERMIS WORLD CONGRESS
Tissue Engineering and Regenerative Medicine International Society (Maastricht, Netherlands)
2017/05 Poster communication about "Unveiling a novel crosstalk between histamine and lipopolysaccharide in the modulation of inflammation and neurogenesis in the hippocampus" at the I Symposium in Applied Biochemistry, University of Minho (Braga, Portugal) I Symposium in Applied Biochemistry
University of Minho (Braga, Portugal)
2016/06 Oral communication about "Unveiling a novel crosstalk between histamine and lipopolysaccharide in the modulation of inflammation and neurogenesis in the hippocampus” at the XI ANNUAL CICS-UBI SYMPOSIUM 2016, UBI, Covilhã, Portugal. XI ANNUAL CICS-UBI SYMPOSIUM
University of Beira Interior (Covilhã, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018 - 2019/05/22 Participated in organization of the I festival Pint of Science at Braga (Portugal) (2019/05/20 - 2019/05/22)
Festival (Member of the Organising Committee)
2018 - 2018 Participated in organization of the "I international symposium Secretome With]Out[ Borders" at School of Medicine (UM, Braga, Portugal). (2018/12/06 - 2018/12/07)
Symposium (Member of the Organising Committee)
 Universidade do Minho, Portugal
2015 - 2015 Participated in organization of the "IV Symposium on Employment and Opportunities in Biomedical Sciences" at UBIMedical (Covilhã, Portugal) (2015/05/27 - 2015/05/27)
Symposium (Member of the Organising Committee)
 UBIMedical , Portugal
2013 - 2014 Participated in organization of the "V National Conferences of Biomedical Sciences" at FCS (UBI, Covilhã, Portugal). (2014/03/13 - 2014/03/15)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior, Portugal
2012 - 2013 Participated in organization of the "I Cycle of Biomedical Afternoon Conferences" at FCS (UBI, Covilhã, Portugal) (2013 - 2013)
Conference (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/10/10 - 2019/10/12 Attended the "11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)", Faculty of Pharmacy, Lisbon, Portugal.
Meeting
 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2012 - 2015 Biomedical Sciences Students' Association (UBI, Covilhã, Portugal) - Responsible for the Marketing and Communication Department Responsible for the Marketing and Communication Department

Mentoring / Tutoring

Topic Student name
2022/05/01 - 2022/06/27 Co-Supervisor of a graduation laboratory internship entitled "Efeito do secretoma de Células Estaminais Mesenquimatosas encapsulado em lipossomas funcionalizados - Análise motora e histológica num modelo animal da Doença de Parkinson" Ana Teresa Palha Sousa
2021/12/01 - 2022/01/15 Co-Supervisor of a laboratory rotation entitled "New approaches for stem-cell secretome encapsulation using lipid-based systems" Rúben Luís Silva
Distinctions

Award

2017 Best poster communication in "I Symposium in Applied Biochemistry" at University of Minho
Universidade do Minho, Portugal