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I am a young Portuguese researcher interested in energy metabolism and cell regulation. I finished my Bachelor's degree in Biochemistry in 2017 and my Master's degree in Cellular and Molecular Biology in 2020, both at the University of Coimbra. During this period, I worked mostly on understanding the hepatic metabolic dysregulation during Non-Alcoholic Fatty Liver Disease. This work led to ten poster presentations (four 1st authorships), four oral communications, four journal articles (1 first authorship) and my MSc dissertation. In March 2021, I started working as a Research Fellow at the University of Florence. There, I studied the microbiome's interaction with host metabolism, having done an oral communication that led to a conference paper (1st authorship) and published 2 journal articles (co-authorship). In 2022, I enrolled on the PhD programme in Experimental Biology and Biomedicine at the University of Coimbra with a funded FCT grant (2022.10983.BD) to study "The role of exogenous and endogenous fructose turnover in adipose tissue dysfunction during the development of Type 2 Diabetes". This project is a collaboration between the Intermediary Metabolism group (Centre for Innovative Biology and Biomedicine, Portugal), where I am supervised by Professor John Jones, and the Clinical Diabetology and Metabolism group (Uppsala University, Sweden), where Professor Jan Eriksson is my supervisor. Since my PhD began, I have shared my work in three conferences in the form of a poster and two oral communications.
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Identification

Personal identification

Full name
Ana Maria Reis Costa
Gender
Female

Citation names

  • Reis-Costa, Ana
  • Costa, Ana

Author identifiers

Ciência ID
1A16-1045-6D94
ORCID iD
0000-0002-0892-7164

Email addresses

  • anamrcosta96@gmail.com (Personal)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/11 - 2026/10
Ongoing
 Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2023/04/03 - 2023/04/14
Concluded
 Advanced Course ONE HEALTH: A Metabolic Approach from the Cell to Society (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 18
2023/03/09 - 2023/03/10
Concluded
 Symposium Clearing the Smoke on Medical Cannabis: The importance of the Endocannabinoid System in Health and Disease (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/02/13 - 2023/02/24
Concluded
 Advanced Course Principles and Practice in Drug Development (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 19
2022/11/07 - 2022/12/09
Concluded
 Advanced Course Connecting Researchers with the Society and Industry (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 18
2022/11/14 - 2022/11/25
Concluded
 VI Modular Training in Laboratory Animal Science Function A, B and Modules 20, 21 and 22 (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

CNC.IBILI, Portugal
2022/10/30 - 2022/11/04
Concluded
 Advanced Course Experimental Science Design (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 20
2022/10/10 - 2022/10/28
Concluded
 Advanced Course Core Technologies (Curso de doutoramento (conclusão de unidades curriculares))
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 18
2018/07/03 - 2020/12/18
Concluded
 Biologia Celular e Molecular (Mestrado)
Major in Área de especialização: Biologia Molecular e Celular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The impact of different lipogenic diets on direct and indirect pathway contributions to hepatic glycogen synthesis" (THESIS/DISSERTATION)
 18
2020/01/28 - 2020/01/28
Concluded
 Principles and applications of NMR spectroscopy (Outros)
Centro de Ciências do Mar, Portugal
2014/09/08 - 2017/06/22
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2021/03/01 - 2022/02/28 Researcher (Research) Università degli Studi di Firenze, Italy
Università degli Studi di Firenze Dipartimento di Biologia, Italy
2019/07 - 2020/12 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Intermediary Metabolism Group - CNC-Biotech, Portugal
2019/02/12 - 2019/03/23 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
MITOLAB – Mitochondrial Research Group, CNC-UC, Portugal
2018/10/21 - 2018/11/15 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Biomaterials & Stem Cell-based Therapeutic Lab, CNC-Biotech, Portugal
2017/01 - 2018/07 Research Trainee (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Institute of Physiology, Coimbra Institute for Clinical and Biomedical Research (iCBR), CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2022/11/01 - Current The role of exogenous and endogenous fructose turnover in adipose tissue dysfunction during the development of Type 2 Diabetes
2022.10983.BD
PhD Student Fellow
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Uppsala Universitet, Sweden

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Reis-Costa, Ana; Jones, John; Jan Eriksson; Maria João Pereira. "The impact of type 2 diabetes on gene expression of fructose metabolism enzymes in human adipose tissue". Paper presented in 58th Annual Scientific Meeting of the European Society for Clinical Investigation, Barcelona, 2024.
    https://doi.org/10.1111/eci.14220
  2. Reis-Costa, Ana; Maria João Pereira; Jan Eriksson; Jones, John. "Modulação metabólica: Influência da cirurgia de bypass gástrico em Y de Roux no metabolismo de frutose". Paper presented in 20º Congresso Português de Diabetes, 2024.
    Accepted
  3. Reis-Costa, Ana; Belew, Getachew Debas; Ludgero Tavares; Francesco Vitali; Agnese Gori; Giovanni Bacci; Carlotta De Filippo; Duccio Cavalieri; John Griffith Jones. Corresponding author: Reis-Costa, Ana. "The impact of lifestyle in Non-Alcoholic Fatty liver disease – Why you should be concerned about your eating habits and the origin of your foods". Paper presented in 4th European Public Health Webinar, 2022.
  4. Reis-Costa, Ana; Belew, Getachew Debas; Ludgero Tavares; Meneses, Maria João; Jones, John. "The impact of different lipogenic diets on indirect pathway contributions to hepatic glycogen synthesis". Paper presented in 57th European Association for the Study of Diabetes (EASD) Annual Meeting 2021, 2021.
Conference paper
  1. Reis-Costa, Ana; Francesco Vitali; Agnese Gori; Giovanni Bacci; Carlotta De Filippo; Duccio Cavalieri. "ONS modelling of diet concepts: further development required by the objective definition of "western diet"". Paper presented in 2nd Integrated Food Ontology Workshop (IFOW), Bolzano, 2021.
    Published
Conference poster
  1. Reis-Costa, Ana; Maria João Pereira; Jan Eriksson; Jones, John. "Metabolic Remodelling in Adipose Tissue: Insights from Rouxen- Y Gastric Bypass Surgery on Fructose Production". Paper presented in IV Metabolism, Ageism & Disease (MAD) Meeting - Disease and Therapeutics: from the Past to Future, 2024.
  2. Reis-Costa, Ana; Belew, Getachew Debas; Barosa, C.; Ivan Viegas; Ludgero Tavares; Jones, John. "O impacto de diferentes dietas lipogénicas na síntese de glicogénio no contexto da doença de Fígado Gordo Não Alcoólico". Paper presented in 19º Congresso Português de Diabetes, 2023.
  3. Tavares, Gabriela; Marques, Daniela; Reis-Costa, Ana; Barra, Cátia; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Peripheral dopamine directly acts on insulin sensitive tissue to regulate insulin signalling and metabolic function". Paper presented in 55th Annual Scientific Meeting of European Society for Clinical Investigation (ESCI), virtual meeting, 2021, 2021.
  4. Reis-Costa, Ana; Belew, Getachew Debas; Cristina Barosa; Ivan Viegas; Ludgero Tavares; Jones, John. "The Impact of High-Fat Feeding on Direct and Indirect Pathway Contributions to Hepatic Glycogen Synthesis in a Mouse Model of Non-Alcoholic Fatty Liver Disease". Paper presented in 54th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) | COVID-19 Edition, 2020.
  5. Costa, Ana; Giada di Nunzio; Belew, Getachew Debas; Torres, Alejandra; Ludgero Tavares; Jones, John. "Alterações na lipogénese de novo hepática em murganhos submetidos ao xarope HFCS-55 rico em frutose". Paper presented in 16º Congresso Português de Diabetes, 2020.
  6. Tavares, Gabriela; Marques, Daniela; Costa, Ana; Barra, Cátia; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signaling with bromocriptine improves glucose and lipid metabolism in an obese type 2 diabetic animal model". Paper presented in 55th Annual Meeting of the European Association for the Study of Diabetes Meeting (EASD), 2019.
  7. Tavares, Gabriela; Marques, Daniela; Barra, Cátia; Reis-Costa, Ana; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signalling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue in a type 2 diabetic obese animal model". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  8. Barra, Cátia; Reis-Costa, Ana; Tavares, Gabriela; Marques, Daniela; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  9. Barra, Cátia; Reis-Costa, Ana; Tavares, Gabriela; Marques, Daniela; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "A bromocriptina reduz a esteatose hepática por modulação da sinalização dopaminérgica no fígado". Paper presented in 15º Congresso Português de Diabetes (SPD), 2019.
  10. Matafome, Paulo; Marques, Daniela; Costa, Ana; Barra, Cátia; Santos, Ana Sofia; Rodrigues, Tiago; Sacramento, Joana; Melo, bernardete; Seica, Raquel. "A bromocriptina na diabetes tipo 2: alterações da sensibilidade à insulina no fígado e no tecido adiposo". Paper presented in 14º Congresso Português de Diabetes, 2018.
Journal article
  1. Ana Reis-Costa; Getachew D. Belew; Ivan Viegas; Ludgero C. Tavares; Maria João Meneses; Bárbara Patrício; Amalia Gastaldelli; Maria Paula Macedo; John G. Jones. "The Effects of Long-Term High Fat and/or High Sugar Feeding on Sources of Postprandial Hepatic Glycogen and Triglyceride Synthesis in Mice". Nutrients (2024): https://doi.org/10.3390/nu16142186.
    10.3390/nu16142186
  2. Stefano Nenciarini; Ana Reis-Costa; Marco Pallecchi; Sonia Renzi; Aldo D’Alessandro; Agnese Gori; Benedetta Cerasuolo; et al. "Investigating Yeast–Lactobacilli Interactions through Co-Culture Growth and Metabolite Analysis". Fermentation (2023): https://doi.org/10.3390/fermentation9110933.
    10.3390/fermentation9110933
  3. "Semantics of Dairy Fermented Foods: A Microbiologist’s Perspective". Foods 11 13 (2022): 1939-1939. http://dx.doi.org/10.3390/foods11131939.
    10.3390/foods11131939
  4. Tavares, Gabriela; Marques, Daniela; Barra, Cátia; Rosendo-Silva, Daniela; Reis-Costa, Ana; Tiago Rodrigues; Patricia Gasparini; et al. "Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes". Molecular Metabolism 51 101241 (2021): http://dx.doi.org/10.1016/j.molmet.2021.101241.
    Open access • Published • 10.1016/j.molmet.2021.101241
Thesis / Dissertation
  1. Costa, Ana Maria Reis. "The impact of different lipogenic diets on direct and indirect pathway contributions to hepatic glycogen synthesis". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2020. http://hdl.handle.net/10316/94040.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/02/24 - 2018/02/25 IV Reunião Nacional de Bioquímicos (RNB) - Anual meeting organized by Associação Nacional de Bioquímicos, which goal is to promote Biochemistry in an event that gathers students and professionals of the field. During this edition, the meeting attracted 300 participants and a project exposition was held for the first time. The abstracts derived from those projects were published with ISBN. (2018/02/24 - 2018/02/25)
Meeting (Member of the Organising Committee)
 Associação Nacional de Bioquímicos - ANBIOQ, Portugal
2015/09 - 2016/03 IX Encontro Nacional de Estudantes de Bioquímica (ENEBIOQ) - Students meeting that aims at promoting the interaction between the students of the field across the country. This event features talks, workshops and leisure activities. (2016/03/18 - 2016/03/21)
Meeting (Member of the Organising Committee)
 Núcleo de Estudantes de Bioquímica da Associação Académica de Coimbra, Portugal

Association member

Society Organization name Role
2023/05/27 - Current Associação Nacional De Bioquímicos - ANBIOQ President
2017/06 - Current Associação Nacional de Bioquímicos - ANBIOQ Member of the SciTech Department
Distinctions

Award

2024 Prémio MDPI - GIFT
Sociedade Portuguesa de Diabetologia, Portugal
2023 Bolsa Charneco da Costa
Sociedade Portuguesa de Diabetologia, Portugal
2020 Bolsa SPD - GIFT
Sociedade Portuguesa de Diabetologia, Portugal

Other distinction

2024 Menção Honrosa - Comunicação Oral de Investigação Fundamental
Sociedade Portuguesa de Diabetologia, Portugal