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A. Cristina Rego (Ph.D.) is Tenure Associate Professor with Aggregation at the Faculty of Medicine, University of Coimbra (FMUC) and head of ‘Mitochondria and Neurodegenerative Disorders’ (MiND) research group at the Center for Neuroscience and Cell Biology (CNC), Univ. Coimbra (UC), and CIBB (Centro de Inovação em Biomedicina e Biotecnologia). AC Rego obtained the Ph.D. in Cell Biology in 1999 at UC under supervision of Prof. Catarina R. Oliveira, was postdoctoral researcher in the Lab of Prof. David G. Nicholls, Univ. Dundee, Scotland, UK, and visiting researcher at the Buck Institute, Novato, CA, USA, from 1998-2000. In 2004-05 AC Rego was the coordinator of the BEB PhD Programme at CNC. Currently, she coordinates the Master in Molecular and Translational Neuroscience at FMUC. AC Rego investigates molecular mechanisms of familial and age-related neurodegenerative disorders, including Alzheimer's and Huntington's diseases, focusing on early-stage changes in mitochondrial function, dynamics and biogenesis, metabolic deregulation and related exosomal content, as well as glutamatergic postsynaptic dysfunction, and transcriptional deregulation. Funding has been garnered by HighQ Foundation (USA), Lundbeck Foundation, 'Instituto de Investigação Interdisciplinar' (IIIUC), 'Fundação para a Ciência e a Tecnologia' (FCT) and EHDN-European Huntington’s Disease Network projects, two 1st edition major prizes/awards promoted by Santa Casa da Misericórdia de Lisboa (SCML) and Fundação Luso Americana para o Desenvolvimento (FLAD), and through industry contracts (e.g. TEVA, Sigma-Tau, Mycology Lab, Prilenia Neurotherapeutics). AC Rego holds a h-factor 51 (Web-of-Science; h-factor 57 at Google Scholar) and >10000 citations, published 144 peer-reviewed publications (of which 113 original articles), 27 book chapters (11 in portuguese) and 140 abstracts in research meetings. AC Rego supervised/co-supervised the work of 12 post-doctoral fellows and investigators, 20 Ph.D. students and 60 Master students (concluded degrees). AC Rego acts as ad-hoc reviewer for scientific journals (e.g. Acta Neuropathologica, Antioxidants and Redox Signal., Brain, Cell Death & Disease, Eur. J. Neuroscience, Free Radic. Biol. and Medicine, Mol. Neurobiol., Neurobiol. Disease, Neuroscience, Redox Biology, Sci. Reports) and funding bodies, namely Parkinson's UK, Alzheimer's Research UK, Austrian Science Fund (FWF), Agence Nationale de la Recherche (ANR), Auckland Medical Research Foundation (AMRF), Telethon Fondazione, Israel Science Foundation, Wellcome Trust, Alzheimer's Association, COST or JPND. AC Rego was member of the ERA-Chair recruitment and monitoring team ERAatUC, at University of Coimbra, ERC Synergy panel member in 2022 and 2024, and member of FENS Programme Committee in 2024. AC Rego was Vice-President of the Portuguese Brain Council (2017-24), President of the Portuguese Society for Neuroscience (SPN) (2019-23) and current President of SPN Fiscal Council (2023-27). Moreover, AC Rego has been a member/vogal of the board of CNC and CNC-UC (2019-20 and 2023-25).
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Identification

Personal identification

Full name
Ana Cristina Carvalho Rego

Citation names

  • Rego, A. Cristina
  • Rego, Ana Cristina

Author identifiers

Ciência ID
1B13-BB39-7943
ORCID iD
0000-0003-0700-3776
Google Scholar ID
https://scholar.google.com.br/citations?hl=pt-PT&user=Z90leqsAAAAJ
Researcher Id
L-4272-2014
Scopus Author Id
7006684894

Email addresses

  • acrego@cnc.uc.pt (Professional)
  • arego@fmed.uc.pt (Professional)

Telephones

Telephone
  • 239820190 (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
Projects

Contract

Designation Funders
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/06 - 2022/07/04 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
PTDC/BTM-TEC/29621/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/06 - 2022/06/30 Transcriptional activity modulation in Alzheimer's disease by inhibitors of histone deacetylases
PTDC/MED-TOX/32316/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/04/01 - 2015/09/30 Role of sirtuin 3 on mitochondrial function and deacetylation of mitochondrial targets: relevance for Huntington's disease
EXPL/BIM-MEC/2220/2013
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/03/01 - 2015/09/30 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
EIT-KIC/IVE/0043/2013
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/05 - 2013/08/04 Analysis of transcription deregulation in brain and peripheral Huntington's disease models - influence of modulating histone deacetylases
PTDC/SAU-FCF/108056/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/02/05 - 2013/07/31 Deciphering the molecular mechanisms linking alpha-synuclein dysfunction and cytotoxicity in Parkinson's disease - the role of GDNF
PTDC/SAU-NEU/101928/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2013/06/30 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09/01 - 2010/12/31 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer's disease
PTDC/SAU-NEU/71675/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/12/31 Silencing Machado-Joseph disease: lentiviral-mediated RNA interference to ataxin-3
PTDC/SAU-FCF/70384/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/09/01 - 2010/11/30 Neuroprotective role of insulin and IGF-1 against Huntington´s disease-associated diabetes
PTDC/SAU-FCF/66421/2006
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs
POCI/SAU-MMO/56055/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 Transcription regulation by FK506 and BDNF control mitochondrial dependent cell death - a protective role in Huntington's disease
POCI/SAU-NEU/57310/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/07/01 - 2008/06/30 Biochemical and Behavioural Study of Opioid-Cocaine Interactions
POCI/SAU-FCF/58330/2004
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Rego, A. Cristina. Neurociências. Portugal: Lidel. 2017.
    Published • Editor
Book chapter
  1. Coelho, Patrícia; Rego, Ana Cristina. "Glucose, glycolysis, and neurodegenerative disorders". In Glycolysis, 333-384. Elsevier, 2024.
    10.1016/b978-0-323-91704-9.00012-4
  2. Coelho, P.; Carvalho Rego, A.C.. "Resveratrol and brain mitochondria". 645-687. 2021.
  3. Ferreira, I.L.; Carmo, C.; Naia, L.; Mota, S.I.; Rego, A.C.. "Assessing mitochondrial function in in vitro and ex vivo models of Huntington’s disease". In Molecular Methods in Biology: Huntington’s Disease. 2018.
    Published • 10.1007/978-1-4939-7825-0_19
  4. Carmo, C.; Naia, L.; Lopes, C.; Rego, A.C.. "Mitochondrial dysfunction in huntington’s disease". In Polyglutamine Disorders. Advances in Experimental Medicine and Biology. 2018.
    Published • 10.1007/978-3-319-71779-1_3
  5. Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.. "Cocaine as a neurotoxin". In Handbook of Neurotoxicity and Biology. 2013.
    10.1007/978-1-4614-5836-4_81
  6. Cunha-Oliveira, Teresa; Rego, Ana Cristina; Carvalho, Félix; Oliveira, Catarina R.. "Medical Toxicology of Drugs of Abuse". 2013.
    https://doi.org/10.1016/B978-0-12-398336-7.00017-6
  7. Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, A. Cristina; Oliveira, Catarina R.. "Neurotoxicity of cocaine". In Cocaine Abuse: Pharmacology, Treatment and Relapse Prevention. Nova Science Publishers, Inc., 2012.
    Published
  8. Cunha-Oliveira, Teresa; Ferreira, Ildete L; Rego, A Cristina. "Consequences of mitochondrial dysfunction in Huntington's Disease and protection via phosphorylation pathways". InTech- Open Access Publisher, 2012.
  9. Rego, A. Cristina; Rosenstock, T.R.; Brett, Ana C.. "Neuronal pathways affected in Huntington’s disease". In Multidisciplinary Viewpoint on Neurodegenerative Diseases, edited by Di Carlo, M., San Biagio, P. L. and Bulone, D., Ed. 2012.
    Accepted
  10. Rego, A. Cristina; Rosenstock, T.R.. "Modified mitochondrial dynamics, turnover and function in neurodegeneration: A focus on Huntington’s disease". In Cellular Bioenergetics in Health and Diseases: New Perspectives in Mitochondrial Biology, edited by Lou, P.-H. and Petersen, N., Eds.. 2012.
    Published
  11. Perfeito, R.; Rego, A. Cristina. "Post-translational modifications of alpha-synuclein and mitochondrial dysfunction in Parkinson’s disease". In Protein Misfolding in Biology and Disease, 203-230. 2008.
    Published
  12. Ribeiro, S.M.-.; Almeida, L.P.D.; Carvalho, A.L.; Rego, A.C.. "Polyglutamine expansion diseases - The case of machado-joseph disease". In Interaction Between Neurons and Glia in Aging and Disease, edited by Malva J.; Rego A.C.; Cunha R.; Oliveira C., Eds. 2007.
    10.1007/978-0-387-70830-0_18
Journal article
  1. Filipa Almeida; Ildete L. Ferreira; Luana Naia; Daniela Marinho; Ana Catarina Vilaça-Ferreira; Marta D. Costa; Sara Duarte-Silva; Patrícia Maciel; A. Cristina Rego. "Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado–Joseph Disease". Cells (2023): https://doi.org/10.3390/cells12192397.
    10.3390/cells12192397
  2. Sandra I. Mota; Lígia Fão; Patrícia Coelho; A. Cristina Rego. "Uncovering the Early Events Associated with Oligomeric Aß-Induced Src Activation". Antioxidants (2023): https://doi.org/10.3390/antiox12091770.
    10.3390/antiox12091770
  3. Daniela Marinho; Ildete Luísa Ferreira; Ricardo Lorenzoni; Sandra M. Cardoso; Isabel Santana; A. Cristina Rego. "Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease". Aging Cell (2023): https://doi.org/10.1111/acel.13895.
    10.1111/acel.13895
  4. Ildete L. Ferreira; Solange Costa; Bruno J. Moraes; Ana Costa; Olga Fokt; Daniela Marinho; Vera Alves; Isabel P. Baptista; A. Cristina Rego. "Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Blood Mononuclear Cells". Antioxidants (2023): https://doi.org/10.3390/antiox12020226.
    10.3390/antiox12020226
  5. Lígia Fão; Patrícia Coelho; Luís Duarte; Rita Vilaça; Michael R. Hayden; Sandra I. Mota; Ana Cristina Rego. "Restoration of c-Src/Fyn Proteins Rescues Mitochondrial Dysfunction in Huntington's Disease". Antioxidants & Redox Signaling (2023): https://doi.org/10.1089/ars.2022.0001.
    10.1089/ars.2022.0001
  6. Mariana Pires; Ana Cristina Rego. "Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24010778.
    10.3390/ijms24010778
  7. Beatriz, Margarida; Rodrigues, Ricardo J.; Vilaça, Rita; Egas, Conceição; Pinheiro, Paulo S.; Daley, George Q.; Schlaeger, Thorsten M.; et al. "Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons". Theranostics 13 11 (2023): 3707-3724. http://dx.doi.org/10.7150/thno.81981.
    Published • 10.7150/thno.81981
  8. Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla. Corresponding author: Lopes, Carla. "Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease". Journal of Extracellular Biology 1 10 (2022): e65. http://dx.doi.org/10.1002/jex2.65.
    Published • 10.1002/jex2.65
  9. Lígia Fão; Patrícia Coelho; Ricardo J. Rodrigues; A. Cristina Rego. "Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity". Cells (2022): https://doi.org/10.3390/cells11193063.
    10.3390/cells11193063
  10. Coelho, P.; Fão, L.; Mota, S.; Rego, A.C.. "Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases". Ageing Research Reviews 80 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85133769957&partnerID=MN8TOARS.
    10.1016/j.arr.2022.101667
  11. Carvalho da Silva, A.M.; Lemos, C.; Silva, H.B.; Ferreira, I.L.; Tomé, A.R.; Rego, A.C.; Cunha, R.A.. "Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85128461886&partnerID=MN8TOARS.
    10.3389/fnagi.2022.835885
  12. Fão, L.; Rego, A.C.. "Mitochondrial and redox-based therapeutic strategies in Huntington's disease.". Antiox. Redox Signal. 34 8 (2021): 650-673.
    Published • ---
  13. Toledo, Juan P.; Fernández-Pérez, Eduardo J.; Ferreira, Ildete L.; Marinho, Daniela; Riffo-Lepe, Nicolas O.; Pineda-Cuevas, Benjamin N.; Pinochet-Pino, Luis F.; et al. "Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease". Frontiers in Neuroscience 15 (2021): 617821. http://dx.doi.org/10.3389/fnins.2021.617821.
    Published • 10.3389/fnins.2021.617821
  14. Luana Naia; Catarina Carmo; Susanna Campesan; Lígia Fão; Victoria E. Cotton; Jorge Valero; Carla Lopes; et al. "Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics". Free Radical Biology and Medicine 163 (2021): 163-179. https://doi.org/10.1016/j.freeradbiomed.2020.11.031.
    10.1016/j.freeradbiomed.2020.11.031
  15. Rego, A. Cristina. "Neuronal cell-based high throughput screen reveals luteolin as mitochondrial enhancer through modulation of mitochondria-endoplasmic reticulum coupling.". BMC Biology (2021):
    In press • 10.3389/fncel.2021.641264
  16. Rego, A. Cristina. "The Sigma-1 receptor mediates pridopidine rescue of mitochondrial function in Huntington disease models.". Neurotherapeutics (2021):
    In press • 10.3389/fncel.2021.641264
  17. Rego, A. Cristina. "MPV17 mutations are associated with a quiescent energetic metabolic profile.". Front. Cell. Neurosci. (2021):
    In press • 10.3389/fncel.2021.641264
  18. Beatriz, M.; Lopes, C.; Ribeiro, A.C.S.; Rego, A.C.C.. "Revisiting cell and gene therapies in Huntington’s disease". Journal of Neuroscience Research 99 7 (2021): 1744-1762. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104595808&partnerID=MN8TOARS.
    10.1002/jnr.24845
  19. Moraes, B.J.; Coelho, P.; Fão, L.; Ferreira, I.L.; Rego, A.C.. "Modified Glutamatergic Postsynapse in Neurodegenerative Disorders". Neuroscience 454 (2020): 116-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078098057&partnerID=MN8TOARS.
    Published • 10.1016/j.neuroscience.2019.12.002
  20. Cortes, L.; Malva, J.; Rego, A.C.; Pereira, C.F.. "Calcium signaling in aging and neurodegenerative diseases 2019". International Journal of Molecular Sciences 21 3 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078188992&partnerID=MN8TOARS.
    10.3390/ijms21031125
  21. Silva, D.F.; Candeias, E.; Esteves, A.R.; Magalhães, J.D.; Ferreira, I.L.; Nunes-Costa, D.; Rego, A.C.; Empadinhas, N.; Cardoso, S.M.. "Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons". Journal of Neuroinflammation 17 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85095130862&partnerID=MN8TOARS.
    10.1186/s12974-020-02004-y
  22. Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C.. "Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS.
    10.3389/fcell.2020.576592
  23. Ferreiro, E.; Lanzillo, M.; Canhoto, D.; Carvalho da Silva, A.M.; Mota, S.I.; Dias, I.S.; Ferreira, I.L.; et al. "Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model". Neurobiology of Aging 92 (2020): 98-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084468542&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2020.04.003
  24. Chrysoula Dioli; Patrícia Patrício; Nuno Sousa; Nikolaos Kokras; Christina Dalla; Sara Guerreiro; Miguel A. Santos-Silva; et al. "Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields". Translational Psychiatry 9 1 (2019): https://doi.org/10.1038/s41398-019-0477-7.
    Published • 10.1038/s41398-019-0477-7
  25. Ribeiro, M.F.; Genebra, T.; Rego, A.C.; Rodrigues, C.M.P.; Solá, S.. "Amyloid ß Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics". Molecular Neurobiology 56 6 (2019): 3922-3936. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053603434&partnerID=MN8TOARS.
    10.1007/s12035-018-1342-z
  26. Pinho, R.; Paiva, I.; Jercic, K.G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C.; Garcia-Esparcia, P.; et al. "Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein". Human molecular genetics 28 1 (2019): 31-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058740345&partnerID=MN8TOARS.
    10.1093/hmg/ddy326
  27. Fão, L.; Mota, S.I.; Rego, A.C.. "c-Src regulates Nrf2 activity through PKCd after oxidant stimulus". Biochimica et Biophysica Acta - Molecular Cell Research 1866 4 (2019): 686-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060844195&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2019.01.011
  28. Fão, L.; Mota, S.I.; Rego, A.C.. "Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases". Ageing Research Reviews 54 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070827540&partnerID=MN8TOARS.
    10.1016/j.arr.2019.100942
  29. Rego, Ana. "A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.". Human molecular genetics (2018): https://doi.org/10.1093/hmg/ddy119.
    10.1093/hmg/ddy119
  30. Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al. "Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant". Neuromuscular Disorders 28 4 (2018): 350-360.
  31. Ferreiro, E.; Pita, I.R.; Mota, S.I.; Valero, J.; Ferreira, N.R.; Fernandes, T.; Calabrese, V.; et al. "Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus". Oncotarget 9 68 (2018): 32929-32942. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052580513&partnerID=MN8TOARS.
    10.18632/oncotarget.25978
  32. Silva, A.C.; Ferreira, I.L.; Hayden, M.R.; Ferreiro, E.; Rego, A.C.. "Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1864 1 (2018): 34-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031746642&partnerID=MN8TOARS.
    10.1016/j.bbadis.2017.09.009
  33. Naia, L.; Rego, A. Cristina. "Isolation and maintenance of striatal neurons.". Bio-protocol 8 8 (2018): e2823.
    Published • 10.21769/BioProtoc.2823
  34. Rego, Ana. "The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.". Human molecular genetics (2017): https://doi.org/10.1093/hmg/ddx298.
    10.1093/hmg/ddx298
  35. Naia, L.; Cunha-Oliveira, T.; Rodrigues, J.; Rosenstock, T.R.; Oliveira, A.; Ribeiro, M.; Carmo, C.; et al. "Histone deacetylase inhibitors protect against pyruvate dehydrogenase dysfunction in huntington’s disease". Journal of Neuroscience 37 10 (2017): 2776-2794. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014750770&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2006-14.2016
  36. Naia, L.; Rosenstock, T.R.; Oliveira, A.M.; Oliveira-Sousa, S.I.; Caldeira, G.L.; Carmo, C.; Laço, M.N.; et al. "Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington’s Disease Models". Molecular Neurobiology 54 7 (2017): 5385-5399. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984887332&partnerID=MN8TOARS.
    10.1007/s12035-016-0048-3
  37. Perfeito, R.; Ribeiro, M.; Rego, A.C.. "Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells". Archives of Toxicology 91 3 (2017): 1245-1259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978795483&partnerID=MN8TOARS.
    10.1007/s00204-016-1788-6
  38. Naia, L.; Ferreira, I.L.; Ferreiro, E.; Rego, A.C.. "Mitochondrial Ca2+ handling in Huntington's and Alzheimer's diseases – Role of ER-mitochondria crosstalk". Biochemical and Biophysical Research Communications 483 4 (2017): 1069-1077. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998772500&partnerID=MN8TOARS.
    10.1016/j.bbrc.2016.07.122
  39. Noronha, C.; Perfeito, R.; Laço, M.; Wüllner, U.; Rego, A.C.. "Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing a-Synuclein". Neurochemical Research 42 5 (2017): 1430-1437. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013849882&partnerID=MN8TOARS.
    10.1007/s11064-017-2199-7
  40. Paiva, I.; Pinho, R.; Pavlou, M.A.; Hennion, M.; Wales, P.; Schütz, A.-L.; Rajput, A.; et al. "Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage". Human molecular genetics 26 12 (2017): 2231-2246. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030984416&partnerID=MN8TOARS.
    10.1093/hmg/ddx114
  41. Rego, A. Cristina. "Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?". Molecular neurobiology (2016): https://doi.org/10.1007/s12035-016-9714-8.
    10.1007/s12035-016-9714-8
  42. Lopes, C.; Aubert, S.; Bourgois-Rocha, F.; Barnat, M.; Rego, A.C.; Déglon, N.; Perrier, A.L.; Humbert, S.. "Dominant-negative effects of adult-onset huntingtin mutations alter the division of human embryonic stem cells-derived neural cells". PLoS ONE 11 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959377608&partnerID=MN8TOARS.
    10.1371/journal.pone.0148680
  43. Naia, L.; Ribeiro, M.; Rodrigues, J.; Duarte, A.I.; Lopes, C.; Rosenstock, T.R.; Hayden, M.R.; Rego, A.C.. "Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin". Neuropeptides 58 (2016): 73-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957398906&partnerID=MN8TOARS.
    10.1016/j.npep.2016.01.009
  44. Oliveira, A.M.; Cardoso, S.M.; Ribeiro, M.; Seixas, R.S.G.R.; Silva, A.M.S.; Rego, A.C.. "Protective effects of 3-alkyl luteolin derivatives are mediated by Nrf2 transcriptional activity and decreased oxidative stress in Huntington's disease mouse striatal cells". Neurochemistry International 91 (2015): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84950980628&partnerID=MN8TOARS.
    10.1016/j.neuint.2015.10.004
  45. Esteves, S.; Duarte-Silva, S.; Naia, L.; Neves-Carvalho, A.; Teixeira-Castro, A.; Rego, A.C.; Silva-Fernandes, A.; Maciel, P.. "Limited effect of chronic valproic acid treatment in a mouse model of Machado-Joseph disease". PLoS ONE 10 10 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949591193&partnerID=MN8TOARS.
    10.1371/journal.pone.0141610
  46. Silva, A.; Naia, L.; Dominguez, A.; Ribeiro, M.; Rodrigues, J.; Vieira, O.V.; Lessmann, V.; Rego, A.C.. "Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntington's Disease". Neurodegenerative Diseases 15 4 (2015): 207-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939565482&partnerID=MN8TOARS.
    10.1159/000375447
  47. Silva, A.; Naia, L.; Dominguez, A.; Ribeiro, M.; Rodrigues, J.; Vieira, O.V.; Lessmann, V.; Rego, A.C.. "Erratum: Overexpression of BDNF and Full-Length TrkB Receptor Ameliorate Striatal Neural Survival in Huntingtons Disease (Neurodegenerative Diseases (2015) 15 (207-218) DOI:10.1159/000375447)". Neurodegenerative Diseases 15 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84939538133&partnerID=MN8TOARS.
    10.1159/000433587
  48. Naia, L.; Rego, A.C.. "Sirtuins: Double players in Huntington's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 10 (2015): 2183-2194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938718400&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.07.003
  49. Mota, S.I.; Costa, R.O.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.03.015
  50. Ferreira, Ildete Luísa; Ferreiro, Elisabete; Schmidt, Jeannette; Cardoso, João M; Pereira, Cláudia M F; Carvalho, Ana Luísa; Oliveira, Catarina R; Rego, A Cristina; Rego, A. Cristina. "Aß and NMDAR activation cause mitochondrial dysfunction involving ER calcium release". Neurobiology of aging (2015): http://hdl.handle.net/10316/80131.
    10.1016/j.neurobiolaging.2014.09.006
  51. Rego, A. Cristina. "OXPHOS dysfunction regulates integrin-ß1 modifications and enhances cell motility and migration.". Human molecular genetics (2014): https://doi.org/10.1093/hmg/ddu612.
    10.1093/hmg/ddu612
  52. Perfeito, R.; Lázaro, D.F.; Outeiro, T.F.; Rego, A.C.. "Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells". Molecular and Cellular Neuroscience 62 (2014): 51-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906751686&partnerID=MN8TOARS.
    10.1016/j.mcn.2014.08.002
  53. Mota, S.I.; Ferreira, I.L.; Rego, A.C.. "Dysfunctional synapse in Alzheimer's disease - A focus on NMDA receptors". Neuropharmacology 76 PART A (2014): 16-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886641553&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2013.08.013
  54. Mota, S.I.; Ferreira, I.L.; Valero, J.; Ferreiro, E.; Carvalho, A.L.; Oliveira, C.R.; Rego, A.C.. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway". Experimental Neurology 261 (2014): 698-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908339906&partnerID=MN8TOARS.
    10.1016/j.expneurol.2014.07.023
  55. Naia, L.; Ferreira, I.L.; Cunha-Oliveira, T.; Duarte, A.I.; Ribeiro, M.; Rosenstock, T.R.; Laço, M.N.; et al. "Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts". Molecular Neurobiology 51 1 (2014): 331-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938698507&partnerID=MN8TOARS.
    10.1007/s12035-014-8735-4
  56. Brett, A.C.; Rosenstock, T.R.; Rego, A.C.. "Current therapeutic advances in patients and experimental models of Huntington's disease". Current Drug Targets 15 3 (2014): 313-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896718561&partnerID=MN8TOARS.
    10.2174/1389450114666131124140704
  57. Lopes, C.; Ribeiro, M.; Duarte, A.I.; Humbert, S.; Saudou, F.; Pereira De Almeida, L.; Hayden, M.; Rego, A.C.. "IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice". Molecular Neurobiology 49 3 (2014): 1126-1142. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902546185&partnerID=MN8TOARS.
    10.1007/s12035-013-8585-5
  58. Ribeiro, Márcio; Rosenstock, Tatiana R.; Oliveira, Ana M.; Oliveira, Catarina R.; Rego, A. Cristina; Ribeiro, M.; Rosenstock, T.R.; et al. "Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells". Free Radical Biology and Medicine 74 (2014): 129-144. http://hdl.handle.net/10316/27852.
    10.1016/j.freeradbiomed.2014.06.023
  59. Caldeira, G.L.; Ferreira, I.L.; Rego, A.C.. "Impaired transcription in Alzheimer's disease: Key role in mitochondrial dysfunction and oxidative stress". Journal of Alzheimer's Disease 34 1 (2013): 115-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874303866&partnerID=MN8TOARS.
    10.3233/JAD-121444
  60. Silva, A.C.; Almeida, S.; Laço, M.; Duarte, A.I.; Domingues, J.; Oliveira, C.R.; Januário, C.; Rego, A.C.. "Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic huntington's disease carriers". Mitochondrion 13 6 (2013): 801-809. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887018742&partnerID=MN8TOARS.
    10.1016/j.mito.2013.05.006
  61. Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.. "Oxidative stress and drugs of abuse: An update". Mini-Reviews in Organic Chemistry 10 4 (2013): 321-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892954534&partnerID=MN8TOARS.
    10.2174/1570193X113106660026
  62. Ribeiro, M.; Silva, A.C.; Rodrigues, J.; Naia, L.; Rego, A.C.. "Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells-protective effect oflcystamine and creatine". Toxicological Sciences 136 2 (2013): 487-499. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890357270&partnerID=MN8TOARS.
    10.1093/toxsci/kft199
  63. Perfeito, Rita; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Perfeito, R.; Cunha-Oliveira, T.; Rego, A.C.. "Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse". Free Radical Biology and Medicine 53 9 (2013): 1791-1806. http://hdl.handle.net/10316/44869.
    10.1016/j.freeradbiomed.2013.05.042
  64. Laço, M.N.; Cortes, L.; Travis, S.M.; Paulson, H.L.; Rego, A.C.. "Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3". PLoS ONE 7 9 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84866103154&partnerID=MN8TOARS.
    10.1371/journal.pone.0043563
  65. Mota, S.I.; Ferreira, I.L.; Pereira, C.; Oliveira, C.R.; Rego, A.C.. "Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures". Current Alzheimer Research 9 7 (2012): 844-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866468436&partnerID=MN8TOARS.
    10.2174/156720512802455322
  66. Ferreira, I.L.; Bajouco, L.M.; Mota, S.I.; Auberson, Y.P.; Oliveira, C.R.; Rego, A.C.. "Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures". Cell Calcium 51 2 (2012): 95-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856958510&partnerID=MN8TOARS.
    10.1016/j.ceca.2011.11.008
  67. Perfeito, R.; Rego Prof., A.C.. "Role of alpha-synuclein and Parkinson's disease-associated mitochondrial dysfunction,Papel da alfa-sinucleína e da disfunção mitocondrial associada à doença de Parkinson". Revista Neurociencias 20 2 (2012): 273-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863884807&partnerID=MN8TOARS.
  68. Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00848.x
  69. Laço, M.N.; Oliveira, C.R.; Paulson, H.L.; Rego, A.C.. "Compromised mitochondrial complex II in models of Machado-Joseph disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1822 2 (2012): 139-149. http://www.scopus.com/inward/record.url?eid=2-s2.0-83155185511&partnerID=MN8TOARS.
    10.1016/j.bbadis.2011.10.010
  70. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS.
    10.1155/2012/735206
  71. Naia, L.; Ribeiro, M.J.; Rego, A.C.. "Mitochondrial and metabolic-based protective strategies in Huntington's disease: The case of creatine and coenzyme Q". Reviews in the Neurosciences 23 1 (2012): 13-28. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860539153&partnerID=MN8TOARS.
    10.1515/rns.2011.060
  72. Ribeiro, Márcio; Rosenstock, Tatiana; Cunha-Oliveira, Teresa; Ferreira, Ildete; Oliveira, Catarina R.; Rego, Ana Cristina; Ribeiro, M.; et al. "Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells". Free Radical Biology and Medicine 53 10 (2012): 1857-1867. http://hdl.handle.net/10316/20850.
    10.1016/j.freeradbiomed.2012.09.004
  73. Pereira, Frederico; Cunha-Oliveira, Teresa; Viana, Sofia; Travassos, Ana Sofia; Nunes, Sara; Silva, Carlos; Prediger, Rui; et al. "Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice". Neurotoxicology and teratology (2012): http://hdl.handle.net/10316/20663.
    10.1016/j.ntt.2012.07.005
  74. Perfeito, R.; Rego, A. Cristina. "Role of alpha-synuclein and Parkinson’s disease-associated mitochondrial dysfunction". Rev. Neurocienc. 20 (2012): 273.
    Published
  75. Duarte, A.I.; Petit, G.H.; Ranganathan, S.; Li, J.-Y.; Oliveira, C.R.; Brundin, P.; Björkqvist, M.; Rego, A.C.. "IGF-1 protects against diabetic features in an in vivo model of Huntington's disease". Experimental Neurology 231 2 (2011): 314-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052520685&partnerID=MN8TOARS.
    10.1016/j.expneurol.2011.06.016
  76. Rosenstock, T.R.; De Brito, O.M.; Lombardi, V.; Louros, S.; Ribeiro, M.; Almeida, S.; Ferreira, I.L.; Oliveira, C.R.; Rego, A.C.. "FK506 ameliorates cell death features in Huntington's disease striatal cell models". Neurochemistry International 59 5 (2011): 600-609. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052936684&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.04.009
  77. Ferreira, I.L.; Cunha-Oliveira, T.; Nascimento, M.V.; Ribeiro, M.; Proença, M.T.; Januário, C.; Oliveira, C.R.; Rego, A.C.. "Bioenergetic dysfunction in Huntington's disease human cybrids". Experimental Neurology 231 1 (2011): 127-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961028116&partnerID=MN8TOARS.
    10.1016/j.expneurol.2011.05.024
  78. Gil-Mohapel, J.M.; Rego, A. Cristina. "Huntington’s disease: A review on the physiopathological aspects". Rev. Neurocienc. 19 (2011): 724-734.
    Published
  79. Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al. "Mitochondrial-dependent apoptosis in Huntington's disease human cybrids". Experimental Neurology 222 2 (2010): 243-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS.
    10.1016/j.expneurol.2010.01.002
  80. Rosenstock, T.R.; Duarte, A.I.; Rego, A.C.. "Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench". Current Drug Targets 11 10 (2010): 1218-1236. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957993152&partnerID=MN8TOARS.
  81. Ferreira, I.L.; Resende, R.; Ferreiro, E.; Rego, A.C.; Pereira, C.F.. "Multiple defects in energy metabolism in Alzheimer's disease". Current Drug Targets 11 10 (2010): 1193-1206. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957994659&partnerID=MN8TOARS.
  82. Rego, A.C.. "Central and peripheral metabolic changes in neurodegenerative diseases". Current Drug Targets 11 10 (2010): 1192. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958018980&partnerID=MN8TOARS.
    Published
  83. Almeida, S.; Cunha-Oliveira, T.; Laço, M.; Oliveira, C.R.; Rego, A.C.. "Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF.". Neurotoxicity research 17 4 (2010): 399-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953951286&partnerID=MN8TOARS.
    10.1007/s12640-009-9116-z
  84. Almeida, S.; Laço, M.; Cunha-Oliveira, T.; Oliveira, C.R.; Rego, A.C.. "BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons". Neurobiology of Disease 35 3 (2009): 448-456. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149169019&partnerID=MN8TOARS.
    10.1016/j.nbd.2009.06.006
  85. Silva, A.; Pereira, J.; Oliveira, C.R.; Relvas, J.B.; Rego, A.C.. "BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype". Journal of Neuroscience Research 87 9 (2009): 1986-1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-66049114646&partnerID=MN8TOARS.
    10.1002/jnr.22041
  86. Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R.. "An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease". Journal of Alzheimer's Disease 16 4 (2009): 741-761. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS.
    10.3233/JAD-2009-0972
  87. Gil, J.M.; Rego, A.C.. "The R6 lines of transgenic mice: A model for screening new therapies for Huntington's disease". Brain Research Reviews 59 2 (2009): 410-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549103857&partnerID=MN8TOARS.
    10.1016/j.brainresrev.2008.12.001
  88. Cunha-Oliveira, T.; Rego, A.C.; Oliveira, C.R.; Cunha-Oliveira, Teresa; Rego, Ana Cristina; Oliveira, Catarina R.. "Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs". Brain Research Reviews 58 1 (2008): 192-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549108542&partnerID=MN8TOARS.
    10.1016/j.brainresrev.2008.03.002
  89. Duarte, A.I.; Santos, P.; Oliveira, C.R.; Santos, M.S.; Rego, A.C.. "Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3ß signaling pathways and changes in protein expression". Biochimica et Biophysica Acta - Molecular Cell Research 1783 6 (2008): 994-1002. http://www.scopus.com/inward/record.url?eid=2-s2.0-43549087343&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.02.016
  90. Almeida, S.; Sarmento-Ribeiro, A.B.; Januário, C.; Rego, A.C.; Oliveira, C.R.. "Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington's disease patients". Biochemical and Biophysical Research Communications 374 4 (2008): 599-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-49449107322&partnerID=MN8TOARS.
    10.1016/j.bbrc.2008.07.009
  91. Gil, J.M.; Rego, A.C.. "Mechanisms of neurodegeneration in Huntington's disease (European Journal of Neuroscience (2008) 27, (2803-2820))". European Journal of Neuroscience 28 10 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-55949114690&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2008.06522.x
  92. Gil, Joana M.; Rego, Ana Cristina; Gil, J.M.; Rego, A.C.. "Mechanisms of neurodegeneration in Huntington's disease". European Journal of Neuroscience 27 11 (2008): 2803-2820. http://hdl.handle.net/10316/8401.
    10.1111/j.1460-9568.2008.06310.x
  93. Cunha-Oliveira, T.; Rego, A.C.; Garrido, J.; Borges, F.; Macedo, T.; Oliveira, C.R.. "Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons". Journal of Neurochemistry 101 2 (2007): 543-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-34047138450&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04406.x
  94. Domingues, A.; Almeida, S.; da Cruz e Silva, E.F.; Oliveira, C.R.; Rego, A.C.. "Toxicity of ß-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-d-aspartate receptor subunits". Neurochemistry International 50 6 (2007): 872-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248172476&partnerID=MN8TOARS.
    10.1016/j.neuint.2007.03.001
  95. Perfeito, R.; Pereira, J.; Oliveira, C.; Bettencourt-Relvas, J.; Rego, A.C.. "Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes". Free Radical Research 41 4 (2007): 444-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947493269&partnerID=MN8TOARS.
    10.1080/10715760601134442
  96. Oliveira, J.M.A.; Jekabsons, M.B.; Chen, S.; Lin, A.; Rego, A.C.; Gonçalves, J.; Ellerby, L.M.; Nicholls, D.G.. "Mitochondrial dysfunction in Huntington's disease: The bioenergetics of isolated and in situ mitochondria from transgenic mice". Journal of Neurochemistry 101 1 (2007): 241-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947200596&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.04361.x
  97. Ferreiro, E.; Eufrásio, A.; Pereira, C.; Oliveira, C.R.; Rego, A.C.. "Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells". Journal of Alzheimer's Disease 12 3 (2007): 223-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549064191&partnerID=MN8TOARS.
  98. Rego, A. Cristina. "Synthesis and cytotoxic profile of 3,4-methylenedioxymethamphetamine ("ecstasy") and its metabolites on undifferentiated PC12 cells: A putative structure-toxicity relationship.". Chemical research in toxicology (2006): https://doi.org/10.1021/tx060123i.
    10.1021/tx060123i
  99. Rego, A. Cristina. "Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells". Ann N Y Acad Sci (2006): http://www.ncbi.nlm.nih.gov/pubmed/17105944.
    10.1196/annals.1369.046
  100. Cunha-Oliveira, T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.; Oliveira, C.R.. "Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide". Toxicology 217 1 (2006): 54-62. http://www.ncbi.nlm.nih.gov/pubmed/16242230.
    10.1016/j.tox.2005.08.022
  101. Oliveira, J.M.A.; Chen, S.; Almeida, S.; Riley, R.; Gonçalves, J.; Oliveira, C.R.; Hayden, M.R.; et al. "Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: Effect of histone deacetylase inhibitors". Journal of Neuroscience 26 43 (2006): 11174-11186. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751106144&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3004-06.2006
  102. Almeida, S.; Brett, A.C.; Góis, I.N.; Oliveira, C.R.; Rego, A.C.; Almeida, Sandra; Brett, Ana C.; et al. "Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons". Journal of Cellular Biochemistry 98 1 (2006): 93-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645957926&partnerID=MN8TOARS.
    10.1002/jcb.20748
  103. Duarte, A.I.; Proença, T.; Oliveira, C.R.; Santos, M.S.; Rego, A.C.; Duarte, Ana I.; Proença, Teresa; et al. "Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress". Diabetes 55 10 (2006): 2863-2870. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882488&partnerID=MN8TOARS.
    10.2337/db06-0030
  104. Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R.. "Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine". Brain Research 1089 1 (2006): 44-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS.
    10.1016/j.brainres.2006.03.061
  105. Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R.. "Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity". Neurotoxicity Research 7 4 (2005): 273-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS.
    10.1007/BF03033885
  106. Silva, V.S.; Duarte, A.I.; Rego, A.C.; Oliveira, C.R.; Gonçalves, P.P.. "Effect of chronic exposure to aluminium on isoform expression and activity of rat (Na+/K+)ATPase". Toxicological Sciences 88 2 (2005): 485-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944510677&partnerID=MN8TOARS.
    10.1093/toxsci/kfi324
  107. Rego, A.C.; de Almeida, L.P.. "Molecular targets and therapeutic strategies in Huntington's Disease". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 361-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144446194&partnerID=MN8TOARS.
    10.2174/1568007054546081
  108. Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Rego, A.C.. "Insulin neuroprotection against oxidative stress in cortical neurons - Involvement of uric acid and glutathione antioxidant defenses". Free Radical Biology and Medicine 39 7 (2005): 876-889. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644623231&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2005.05.002
  109. Carreira, R.; Duarte, A.; Monteiro, P.; Sancha Santos, M.; Rego, A.C.; Oliveira, C.R.; Gonçalves, L.M.; Providência, L.A.. "Carvedilol protects ischemic cardiac mitochondria by preventing oxidative stress | O carvedilol protege mitocôndrias cardíacas isquémicas de lesões induzidas por stress oxidativo". Rev Port Cardiol. 23 11 (2004): 1447-1455. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244328526&partnerID=MN8TOARS.
  110. Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R.. "Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells". Neurochemistry International 45 5 (2004): 693-698. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS.
    10.1016/j.neuint.2004.03.003
  111. Almeida, S.; Domingues, A.; Rodrigues, L.; Oliveira, C.R.; Rego, A.C.. "FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures". Neurobiology of Disease 17 3 (2004): 435-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644265271&partnerID=MN8TOARS.
    10.1016/j.nbd.2004.07.002
  112. Oliveira, M.T.; Rego, A.C.; Macedo, T.R.A.; Oliveira, C.R.. "Drugs of Abuse Induce Apoptotic Features in PC12 Cells". Ann. NY Acad. Sci. 1010 (2003): 667-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342284249&partnerID=MN8TOARS.
    Published • 10.1196/annals.1299.121
  113. Brito, O.; Almeida, S.; Oliveira, C.R.; Rego, A.C.. "Bcl-2 Prevents Loss of Cell Viability and Caspase Activation Induced by 3-Nitropropionic Acid in GT1-7 Cells". Ann. NY Acad. Sci. 1010 (2003): 148-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342284294&partnerID=MN8TOARS.
    Published • 10.1196/annals.1299.024
  114. Rego, A.C.; Oliveira, C.R.. "Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases". Neurochemical Research 28 10 (2003): 1563-1574. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141705360&partnerID=MN8TOARS.
    10.1023/A:1025682611389
  115. Gil, J.; Almeida, S.; Oliveira, C.R.; Rego, A.C.. "Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis". Free Radical Biology and Medicine 35 11 (2003): 1500-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344012006&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2003.08.022
  116. Rego, A. Cristina; Monteiro, Nuno M.; Silva, Ana P.; Gil, Joana; Malva, João O.; Oliveira, Catarina R.; Rego, A.C.; et al. "Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures". Journal of Neurochemistry 86 4 (2003): 792-804. http://hdl.handle.net/10316/8429.
    10.1046/j.1471-4159.2003.01898.x
  117. Oliveira, M.T.; Rego, A.C.; Morgadinho, M.T.; Macedo, T.R.A.; Oliveira, C.R.. "Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells". Ann. NY Acad. Sci. 965 (2002): 487-496. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036290212&partnerID=MN8TOARS.
    Published
  118. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS.
    10.1002/jnr.10282
  119. Rego, A.C.; Lambert, J.J.; Nicholls, D.G.. "Developmental profile of excitatory GABAA responses in cultured rat cerebellar granule cells". NeuroReport 12 3 (2001): 477-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035809757&partnerID=MN8TOARS.
    10.1097/00001756-200103050-00011
  120. Areias, F.M.; Rego, A.Cristina; Oliveira, C.R.; Seabra, R.M.. "Antioxidant effect of flavonoids after ascorbate/Fe2+-induced oxidative stress in cultured retinal cells". Biochemical Pharmacology 62 1 (2001): 111-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035400513&partnerID=MN8TOARS.
    10.1016/S0006-2952(01)00621-9
  121. Rego, A.C.; Ward, M.W.; Nicholls, D.G.. "Mitochondria control AMPA/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells". Journal of Neuroscience 21 6 (2001): 1893-1901. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035869336&partnerID=MN8TOARS.
  122. Rego, A.C.; Santos, M.S.; Areias, F.; Proença, T.; Oliveira, C.R.. "Glutamate regulates the viability of retinal cells in culture". Vision Research 41 7 (2001): 841-851. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035094616&partnerID=MN8TOARS.
    10.1016/S0042-6989(00)00309-6
  123. Rego, A.C.; Vesce, S.; Nicholls, D.G.. "The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells". Cell Death and Differentiation 8 10 (2001): 995-1003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034781572&partnerID=MN8TOARS.
    10.1038/sj.cdd.4400916
  124. Agostinho, P.; Caseiro, P.; Rego, A.C.; Duarte, E.P.; Cunha, R.A.; Oliveira, C.R.. "Adenosine modulation of D-[3H]aspartate release in cultured retina cells exposed to oxidative stress". Neurochemistry International 36 3 (2000): 255-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033979263&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00113-8
  125. Rego, A.C.; Agostinho, P.; Melo, J.; Cunha, R.A.; Oliveira, C.R.. "Adenosine A(2A) receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells". Experimental Eye Research 70 5 (2000): 577-587. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033623815&partnerID=MN8TOARS.
    10.1006/exer.1999.0815
  126. Ward, M.W.; Rego, A.C.; Frenguelli, B.G.; Nicholls, D.G.. "Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells". Journal of Neuroscience 20 19 (2000): 7208-7219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034307759&partnerID=MN8TOARS.
  127. Rego, A.C.; Sancha Santos, M.; Oliveira, C.R.; Rego, Ana Cristina; Sancha Santos, Maria; Oliveira, Catarina Resende. "Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cells". Neurochemistry International 36 2 (2000): 159-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033990365&partnerID=MN8TOARS.
    10.1016/S0197-0186(99)00107-2
  128. Rego, Ana Cristina; Agostinho, Paula; Melo, Joana; Cunha, Rodrigo A.; Oliveira, Catarina R.. "Adenosine A2AReceptors Regulate the Extracellular Accumulation of Excitatory Amino Acids upon Metabolic Dysfunction in Chick Cultured Retinal Cells". (2000): http://hdl.handle.net/10316/4839.
  129. Rego, A.C.; Areias, F.M.; Santos, M.S.; De Oliveira, C.I.R.. "Distinct glycolysis inhibitors determine retinal cell sensitivity to glutamate-mediated injury". Neurochemical Research 24 3 (1999): 351-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032964352&partnerID=MN8TOARS.
    10.1023/A:1020977331372
  130. Rego, A.C.; Oliveira, C.R.. "Influence of ¿-aminobutyric acid on retinal cells excitotoxicity upon glucose deprivation". Neuroscience Research 34 1 (1999): 31-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033026964&partnerID=MN8TOARS.
    10.1016/S0168-0102(99)00030-9
  131. Rego, Ana Cristina; Santos, Maria Sancha; Oliveira, Catarina R.; Rego, A.C.; Santos, M.S.; Oliveira, C.R.. "Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress". Free Radical Biology and Medicine 26 11-12 (1999): 1405-1417. http://hdl.handle.net/10316/4848.
    10.1016/S0891-5849(98)00337-2
  132. Rego, Ana Cristina; Areias, Filipe; Santos, Maria Sancha; Oliveira, Catarina. "Distinct Glycolysis Inhibitors Determine Retinal Cell Sensitivity to Glutamate-Mediated Injury". (1999): http://hdl.handle.net/10316/8510.
  133. Rego, A.C.; Santos, M.S.; Proença, M.T.; Oliveira, C.R.; Rego, Ana Cristina; Santos, Maria Sancha; Proença, Maria Teresa; Oliveira, Catarina R.. "Influence of vitamin E succinate on retinal cell survival". Toxicology 128 2 (1998): 113-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032479530&partnerID=MN8TOARS.
    10.1016/S0300-483X(98)00054-7
  134. Rego, A.C.; Areias, F.M.; Santos, M.S.; Oliveira, C.R.. "Effect of glucose deprivation and acute glutamate exposure in cultured retinal cells". Experimental Neurology 153 1 (1998): 128-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031663392&partnerID=MN8TOARS.
    10.1006/exnr.1998.6865
  135. Rego, A.C.; Oliveira, C.R.. "Alteration of nitric oxide synthase activity upon oxidative stress in cultured retinal cells". Journal of Neuroscience Research 51 5 (1998): 627-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032032525&partnerID=MN8TOARS.
    10.1002/(SICI)1097-4547(19980301)51:5<627::AID-JNR10>3.0.CO;2-#
  136. Rego, Ana Cristina; Areias, Filipe Miguel; Santos, Maria Sancha; Oliveira, Catarina R.. "Effect of Glucose Deprivation and Acute Glutamate Exposure in Cultured Retinal Cells". (1998): http://hdl.handle.net/10316/4857.
  137. Rego, A.C.; Santos, M.S.; Oliveira, C.R.. "Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells". Journal of Neurochemistry 69 3 (1997): 1228-1235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030792543&partnerID=MN8TOARS.
  138. Rego, A.C.; Santos, M.S.; Oliveira, C.R.. "Oxidative stress, hypoxia, and ischemia-like conditions increase the release of endogenous amino acids by distinct mechanisms in cultured retinal cells". Journal of Neurochemistry 66 6 (1996): 2506-2516. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029992779&partnerID=MN8TOARS.
  139. Rego, A.C.; Duarte, E.P.; Oliveira, C.R.. "Oxidative stress in acidic conditions increases the production of inositol phosphates in chick retinal cells in culture". Free Radical Biology and Medicine 20 2 (1996): 175-187. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030034476&partnerID=MN8TOARS.
    10.1016/0891-5849(95)02029-2
  140. Rego, A.C.; Oliveira, C.R.. "Dual effect of lipid peroxidation on the membrane order of retinal cells in culture". Archives of Biochemistry and Biophysics 321 1 (1995): 127-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029081382&partnerID=MN8TOARS.
    10.1006/abbi.1995.1377
  141. Rego, A.C.; Oliveira, C.R.. "Influence of lipid peroxidation on [3H]ketanserin binding to 5-HT2 prefrontal cortex receptors". Neurochemistry International 27 6 (1995): 489-496. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028889729&partnerID=MN8TOARS.
    10.1016/0197-0186(95)80007-8

Other

Other output
  1. Mitochondrial and redox modifications in early stages of Huntington's disease. 2022. Lopes, C.; Ferreira, I.L.; Maranga, C.; Beatriz, M.; Mota, S.I.; Sereno, J.; Castelhano, J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128000218&partnerID=MN8TOARS.
    10.1101/2022.01.14.476381
  2. Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease. 2022. Beatriz, M.; Vilaça, R.; Anjo, S.I.; Manadas, B.; Januário, C.; Rego, A.C.C.; Lopes, C.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127127447&partnerID=MN8TOARS.
    10.1101/2022.02.13.480262