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Sueli Marques Spencer. PhD in Molecular Biology, summa cum laude, on the 2012/06/08 by Universidade de Coimbra. Senior research specialist at Karolinska Institutet. Published 12 peer-reviewed papers in international journals. Area of Natural Sciences with focus in Biological science- Molecular biology. More frequent terms: Single-cell omics; Transcription; Neurodegeneration.
Identification

Personal identification

Full name
Sueli Marques Spencer

Citation names

  • Spencer, Sueli

Author identifiers

Ciência ID
1C10-13F5-511D
ORCID iD
0000-0003-3368-4392

Telephones

Mobile phone
  • (+46) 700322736 (Personal)

Addresses

  • Vasagränd, 7, Lgh 1403, 17753, Järfälla, Stockholm, Sweden (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
French Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Swedish Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Beginner (A1)
Education
Degree Classification
2007/09 - 2012/06/08
Concluded
 Biochemistry (Curso de Especialização Tecnológica)
Major in Molecular Biology
Universidade de Coimbra, Portugal
 Summa cum laude
2002/09 - 2007/07
Concluded
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of alpha-synuclein on Abeta aggregation in Dementia with Lewis bodies." (THESIS/DISSERTATION)
 16
Affiliation

Science

Category
Host institution 		Employer
2018/09/03 - Current Contracted Researcher (Research) Karolinska Institutet, Sweden
Karolinska Institutet, Sweden
2012/10/01 - 2017/03/31 Postdoc (Research) Karolinska Institutet, Sweden
Karolinska Institutet, Sweden
2012/03 - 2012/08 Research Assistant (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
Projects

Grant

Designation Funders
2007/09 - 2012/06/08 Chromatin Remodeling in Alzheimer's disease
SFRH/ BD/ 33188/ 2007
PhD Student Fellow
Universidade de Coimbra, Portugal

Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Marques, S; van Bruggen, D; Castelo-Branco, G. "Single-Cell RNA Sequencing of Oligodendrocyte Lineage Cells from the Mouse Central Nervous System". Methods Mol. Biol. (2019): http://www.ncbi.nlm.nih.gov/pubmed/30820890.
    10.1007/978-1-4939-9072-6_1
  2. Ana Mendanha Falcão; David van Bruggen; Sueli Marques; Mandy Meijer; Sarah Jäkel; Eneritz Agirre; Samudyata; et al. "Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis". Nature Medicine 24 12 (2018): 1837-1844. https://doi.org/10.1038/s41591-018-0236-y.
    10.1038/s41591-018-0236-y
  3. Marques, S; van Bruggen, D; Vanichkina, DP; Floriddia, EM; Munguba, H; Väremo, L; Giacomello, S; et al. "Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development". Dev. Cell (2018): http://www.ncbi.nlm.nih.gov/pubmed/30078729.
    10.1016/j.devcel.2018.07.005
  4. Marques, S; Zeisel, A; Codeluppi, S; van Bruggen, D; Mendanha Falcão, A; Xiao, L; Li, H; et al. "Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system". Science (2016): http://www.ncbi.nlm.nih.gov/pubmed/27284195.
    10.1126/science.aaf6463
  5. Zeisel, A; Muñoz-Manchado, AB; Codeluppi, S; Lönnerberg, P; La Manno, G; Juréus, A; Marques, S; et al. "Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq". Science (2015): http://www.ncbi.nlm.nih.gov/pubmed/25700174.
    10.1126/science.aaa1934
  6. Castelo-Branco, G; Lilja, T; Wallenborg, K; Falcão, AM; Marques, SC; Gracias, A; Solum, D; et al. "Neural stem cell differentiation is dictated by distinct actions of nuclear receptor corepressors and histone deacetylases". Stem Cell Reports (2014): http://www.ncbi.nlm.nih.gov/pubmed/25241747.
    10.1016/j.stemcr.2014.07.008
  7. Spencer, Sueli. "Effect of a-synuclein on amyloid ß-induced toxicity: relevance to Lewy body variant of Alzheimer disease.". Neurochemical research (2013): https://doi.org/10.1007/s11064-013-0982-7.
    10.1007/s11064-013-0982-7
  8. Castelo-Branco, G; Amaral, PP; Engström, PG; Robson, SC; Marques, SC; Bertone, P; Kouzarides, T. "The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells". Genome Biol. (2013): http://www.ncbi.nlm.nih.gov/pubmed/24044525.
    10.1186/gb-2013-14-9-r98
  9. Spencer, Sueli. "Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice". Neuroscience (2012): http://dx.doi.org/10.1016/j.neuroscience.2012.06.029.
    10.1016/j.neuroscience.2012.06.029
  10. Spencer, Sueli. "Modulating Alzheimer's Disease Through Caffeine: A Putative Link to Epigenetics". Journal of Alzheimer's Disease (2011): http://doi.org/10.3233/JAD-2011-110032.
    10.3233/JAD-2011-110032
  11. Spencer, Sueli. "Epigenetics in neurodegeneration: a new layer of complexity.". Progress in neuro-psychopharmacology & biological psychiatry (2010): https://doi.org/10.1016/j.pnpbp.2010.08.008.
    10.1016/j.pnpbp.2010.08.008
  12. Spencer, Sueli. "Alzheimer's disease: the quest to understand complexity.". Journal of Alzheimer's disease : JAD (2010): https://doi.org/10.3233/JAD-2010-100303.
    10.3233/jad-2010-100303

Other

Other output
  1. Improved transcriptome annotation and read-through transcript identification with TIF-Seq2. 2019. Jingwen Wang; Bingnan Li; Sueli Marques; Lars M. Steinmetz; Wu Wei; Vicent Pelechano. https://doi.org/10.1101/859488.
    10.1101/859488
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2016/07/05 Oligodendrocyte heterogeneity in the mouse central nervous system FENS Forum 2016
(Copenhaga, Denmark)
2016/05/15 Oligodendrocyte heterogeneity in the mouse central nervous system Gordon Myelin
(Lucca, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2015 - 2015/06/01 Characterization of novel subpopulation of oligodendrocytes during development
Supervisor of Fatemah Rezayee
Uppsala Universitet, Sweden
2014 - 2014 The role of long non-coding RNAs in Oligodendrocytes development
Co-supervisor of Kedir Hussen Hamza
Uppsala Universitet, Sweden

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2015 - 2018 Executive producer of Frames – Portuguese Film Festival in Sweden from 2015 to 2018. Director of Frames- Portuguese Film Festival in Sweden in 2017 (2015 - 2018)
Festival (Co-organisor)
Distinctions

Award

2016 Best poster award in RNA Society meeting 2016

Other distinction

2020 Project Grant
Jeanssons Stiftelser, Sweden