Miguel Maria da Fonseca Miranda Ferreira Lino (1C1F-4287-AF90)

Curriculum Vitae

Miguel Maria da Fonseca Miranda Ferreira Lino

Miguel Lino (ML) is a researcher at the University of Coimbra and affiliated with the Centre for Innovative Biomedicine and Biotechnology (CIBB). He has an MSc in Biomedical Engineering (IST, Technical University of Lisbon) and a PhD in Biosciences (University of Coimbra, 2017). ML has acquired strong expertise in different fields of knowledge: biomedical engineering, biology, biomaterials and nanotechnology. In his PhD and in the following years, ML made a significant contribution to the development of a cutting-edge research field in the lab of Dr Lino Ferreira, related to the creation of light-triggerable formulations for the intracellular delivery of biomolecules. The work gave origin to one international patent (PCT/IB2016/056229) and publications in prestigious nanotechnology journals (ACS Nano, Nanoscale), which have been highlighted by the national press. In his postdoctoral career, ML has worked on the development of sEV therapeutics for the treatment of cardiovascular/brain disorders, mainly focused on ischemic diseases and sEV targeting strategies. Several articles in high-impact journals (J. of Controlled Release, J. of Extracellular Vesicles, ACS Nano, Nanoscale) have already resulted from his contribution to this field. Overall, he published 20 articles in peer-reviewed journals (all in Q1; average IF>9.4). In the last 4 years, ML was able to increase his scientific independence. From 2020 until 2021, ML was an invited auxiliary researcher at the Faculty of Medicine of the University of Coimbra. Since 2021 he was able to secure: (i) a contract of junior researcher in the national call for Scientific Employment Stimulus (top 8%); (ii) funding as PI and co-PI for FCT exploratory projects (100k €) on sEV-based therapeutics; (iii) mobility grants to perform a collaborative project at Imperial College London. Over the years, he has supervised 2 PhD students, a team of 4 researchers (1 postdoc and 3 MSc fellows) dedicated to sEV therapies, 3 researchers (1 postdoc and 2 MSc fellows) working on sEVs to reverse cell senescence and he has mentored 6 visiting students/researchers. In the last years, he has built a network of contacts with international experts from top institutions: Dr Costanza Emanueli and Dr Césare Terracciano (Imperial College London), Dr Marina Resmini (Queen Mary University of London), Dr Tomas Sobrino (University of Santiago de Compostela), Dr Ana Teixeira (Karolinska Institute), Dr Diana Nascimento (i3S) and Dr Chiara Brovarone (Polytechnic University of Turin). Besides his research activities, he is an invited professor of the syllabus “Regenerative Medicine” of the MSc program in Biomedical Engineering (Univ. Coimbra) and has contributed with lectures for the PhD programme in Biomedicine and Experimental Biology (CNC-UC). From 2019 until 2023, he was the coordinator of the section “Cell Therapies and Tissue Engineering” of the Portuguese Society for Stem Cells and Cell Therapies and since 2023 he is a member of the scientific council of the Multidisciplinary Institute of Ageing. His scientific contributions have been recognized at national and international levels: he has been invited to be a jury member in 7 MSc defences and 4 PhD defences; he gave talks at conferences/symposiums (6 by invitation, 1 keynote lecture); He received 5 poster awards at international conferences. He was invited to be an abstract reviewer for the 7th TERMIS World Congress and to become a review editor of Frontiers in Medical Engineering. He has acted as a reviewer for different journals (ACS Biomaterials Science & Engineering; Cells).

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Identification

Personal identification

Full name: Miguel Maria da Fonseca Miranda Ferreira Lino

Citation names

Lino, Miguel

Author identifiers

Ciência ID: 1C1F-4287-AF90
ORCID iD: 0000-0001-6011-0058

Knowledge fields

Engineering and Technology - Nano-technology - Nano-materials
Medical and Health Sciences - Medical Biotechnology - Biomaterials
Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Portuguese (Mother tongue)

Education

	Degree	Classification
2017 Concluded	PhD in Biosciences, Specialization in biotechnology (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Light-triggerable Nanomaterials for the Delivery of Biomolecules" (THESIS/DISSERTATION)	Approved with praise and distinction
2007 Concluded	Integrated Masters in Biomedical Engineering (Mestrado) Universidade de Lisboa, Portugal "Análise ecográfica, estrutural e biomecânica de tendões" (THESIS/DISSERTATION)	17

Affiliation

Science

	Category Host institution	Employer
2022/06/01 - Current	Researcher (Research)	Universidade de Coimbra, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/06/01 - 2022/05/31	Invited Auxiliary Researcher (Research)	Faculty of Medicine of the University of Coimbra, Portugal

2021/08 - 2022/03	Visiting Researcher (Research)	Faculty of Medicine of the University of Coimbra, Portugal
	Imperial College London, United Kingdom
2018/10/01 - 2021/03/31	Contracted Researcher (Research)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Others

	Category Host institution	Employer
2021/03/01 - 2021/05/31	Scientific report writer (responsible for the elaboration of the periodic and final technical reports of the ERA@UC project)	Faculty of Medicine of the University of Coimbra, Portugal
	Faculty of Medicine of the University of Coimbra, Portugal
2017/11/01 - 2018/09/30	Post-doctoral researcher (project ERA@UC)	CNC.IBILI, Portugal

2016/02/01 - 2017/10/31	Research assistant (project Nanotrigger ERC Grant Agreement nº 307384)	CNC.IBILI, Portugal

2012/01/01 - 2017/06/20	PhD student (Doctoral program in Biosciences, Specialization in biotechnology)	Universidade de Coimbra, Portugal

2009/09/01 - 2011/12/31	Research assistant. Development of antimicrobial nanomaterials and coatings for biomedical application	Matera Lda, Portugal

Projects

Grant

	Designation	Funders
2021/05 - Current	Synaptic regulation by chronic stress-induced microRNA-186-5p in the prefrontal cortex HR21-01077 Researcher	Obra Social La Caixa Ongoing
2017/11/01 - 2018/09/30	ERA@UC. Ref 669088. ERA Chair in Cellular and Molecular Biology of Ageing Ref 669088 Post-doc Fellow	European Commission Ongoing

Contract

	Designation	Funders
2023/01/01 - Current	Design and development of polymer brush functionalized exosomes for brain targeted delivery of miRNA 2022.02803.PTDC Co-Principal Investigator (Co-PI)
2022/01/01 - Current	A gene-editing nanoparticle formulation for retinal degeneration diseases EXPL/BIA-CEL/0989/2021 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - Current	Engineered extracellular vesicles for neuroprotection EXPL/BTM-ORG/1348/2021 Principal investigator	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - Current	EXO-HEART: Protecção e regeneração cardíaca mediada pela administração sistémica e direcionada de exosomas. PTDC/BTM-SAL/29919/2017 Researcher	Fundação para a Ciência e a Tecnologia Ongoing
2018/07/06 - Current	A light-activatable nanoparticle library for the delivery of RNA-based therapies PTDC/EQU-EQU/29414/2017 Post-doc CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016 - 2019	Plataformas terapêuticas para acidentes vasculares cerebrais SII&DT 3386 StrokeTherapy Researcher	Concluded

Other

	Designation	Funders
2012/11/01 - 2017/06/20	Triggerable nanomaterials to modulate cell activity 307384 PhD Student Fellow CNC.IBILI, Portugal	European Research Council Concluded
2010 - 2012	Antimicrobial coatings and materials based in polycationic polymers 0000 Researcher	IAPMEI

Outputs

Publications

Conference abstract	Lino, Miguel; Rondão, Tiago; Banerjee, A; Aires, I; Rodrigues, M; Fernandes, Dominique; Freitas, J; et al. "Extracellular Vesicles Secreted by Mononuclear Cells from Umbilical Cord Blood Induce Neuroprotection and Angiogenesis and Attenuate Microglia Reactivity in a Mouse Model of Brain Ischemia". Paper presented in European Journal of Clinical Investigation, 2022. Published
Conference paper	Henriques-Antunes H; Renato Cardoso; Alessandra Zonari; Joana Correia; Leal, Ermelindo C; Adrien Jimenez-Balsa; Lino, Miguel; Gomes, Célia. "Oral Talks - Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel". 2020. 10.1111/eci.13108 Banerjee, Arnab; Rondao, Tiago; Sereno, Jose; Alves, Vitor; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, Lino. "PET imaging and in vivo bio-distribution of small extracellular vesicles". 2019.
Conference poster	Carlos Jesus; Miguel Lino; Hugo Fernandes. "Scalable production of Extracellular Vesicles from Mesenchymal Stem Cells using a Hollow Fiber Bioreactor". Paper presented in 2nd MOVE Symposium, 2024. Cláudia M. Deus; Soares, Susana; Ferreira-Rodrigues, M; Rai, Akhilesh; Lino, Miguel; Ferreira, Lino. Corresponding author: Cláudia M. Deus. "To reset the senescence program in senescent stem/progenitor cells by extracellular vesicles". Paper presented in 33rd Annual Conference of the European Society for Biomaterials, 2023. Miguel Lino. "Small extracellular vesicles for increased neuroprotection and modulation of microglia reactivity in stroke". Paper presented in 2nd Meeting of the Portuguese Network on Extracellular Vesicles, 2023. Miguel Lino. "Extracellular vesicles for neuroprotection and modulation of microglia reactivity in stroke". Paper presented in Joint Meeting ETRS & SPCE-TC, 2023. Magda Ferreira Rodrigues; Ana Carolina Mendes; Susana Soares; Eduardo Pires; Akhilesh Rai; Miguel Lino; Lino Ferreira. Corresponding author: Miguel Lino. "Freeze-dried small extracellular vesicles (sEVs): the next step for sEV clinical applications". Paper presented in Biosystems in Toxicology and Pharmacology meeting., 2022. Inês Albino; Miguel Lino; Francesco Catapano; Costanza Emanueli; Lino Ferreira. Corresponding author: Miguel Lino. "Engineered extracellular vesicles targeting ischemic endothelial cells". Paper presented in 12th International Meeting of the ¿Portuguese Society for Stem Cells ¿and Cell Therapies, 2022. Inês Albino; Miguel Lino; Lino Ferreira. Corresponding author: Miguel Lino. "Engineered Extracellular Vesicles for Brain Targeting and Modulation". Paper presented in ESB-NANOSTEM Joint Sympoium, 2021. Lino, Miguel. "Lignt-controlled systems for the delivery of microRNAs". Paper presented in 4th COST Action CardioRNA MC and WG Meeting, 2020. Lino, Miguel. "Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel". Paper presented in ESCI 2019, 2019. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Lino Ferreira. "Near-infrared triggered release of miRNAs for modulation of cell activity". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Henriques-Antunes; Alessandra Zonari; Lino Ferreira. "Spatio-temporal controlled delivery of miRNAs for modulation of angiogenic activity". Paper presented in 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of cell activity by light-controlled delivery of miRNAS". Paper presented in 6th China-Europe Symposium on Biomaterials and Regenerative Medicine, 2017. Miguel Lino. "Light-controlled release of proteins from gold nanorods". Paper presented in 3rd Symposium in Nanoscience and Biomedical Nanotechnology, 2016.
Journal article	Susana Simões; Lino, Miguel; Angela Barrera; Catarina Rebelo; Francesca Tomatis; Andreia Vilaça; Christopher Breunig; et al. "Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing". Angewandte (2024): https://doi.org/10.1002/anie.202401004. In press Andreia Vilaça; Miguel Lino; Hugo Fernandes; Leon de Windt; Lino Ferreira. "Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells". Molecular Therapy - Nucleic Acids (2024): 10.1016/j.omtn.2024.102233. Published Roberta Bilardo; Adele Leggieri; Francesca Tomatis; Federico Traldi; Alena Vdovchenko; Eleonora Rizzi; Miguel Lino; et al. "N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish". Small (2024): Accepted Inês Albino; Elena Ambrosetti; Ana Teixeira; Paula Sampaio; Miguel M. Lino; Lino Ferreira. Corresponding author: Miguel M. Lino. "Dual Ligand Cooperation in Surface Engineering Drives Extracellular Vesicle Transport at the Blood-Brain Barrier". (2024): Submitted Arnab Banerjee; Lino, Miguel; Carlos Jesus; Quélia Ribeiro; Antero Abrunhosa; Lino Ferreira. "Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles". Journal of Controlled Release 360 (2023): 549-563. https://www.sciencedirect.com/science/article/abs/pii/S0168365923004224. Published João André Sousa; Catarina Bernardes; Sara Bernardo-Castro; Miguel Lino; Inês Albino; Lino Ferreira; José Brás; et al. "Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target". Frontiers in Aging Neuroscience 15 (2023): https://doi.org/10.3389/fnagi.2023.1102809. Published Lino, Miguel; Rondão, Tiago; Arnab Banerjee; Inês Aires; Magda Rodrigues; Tiago Reis; António Santinha; et al. "Small extracellular vesicles administered directly in the brain promote neuroprotection and decrease microglia reactivity in a stroke mouse model". Nanoscale (2023): https://pubs.rsc.org/en/content/articlelanding/2023/nr/d3nr03861k. Published Fernandes, Hugo; Alessandra Zonari; Ricardo Abreu; Sezin Aday; Barão, Marta; Inês Albino; Miguel Lino; et al. "Extracellular vesicles enriched with an endothelial cell pro-survival microRNA impacts skin tissue regeneration". Molecular Therapy - Nucleic Acids (2022): https://doi.org/10.1016/j.omtn.2022.03.018. Published Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Lino, Miguel; Tiago Rondão; Artur Paiva; Lino Ferreira. "Antimicrobial peptide-tether dressing able to enhance wound healing by tissue contact". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c06601. Published Lino, Miguel; Susana Simões; Francesca Tomatis; Inês Albino; Angela Barrera; Denis Vivien; Tomas Sobrino; Lino Ferreira. "Engineered extracellular vesicles as brain therapeutics". Journal of Controlled Release (2021): https://doi.org/10.1016/j.jconrel.2021.08.037. Published Ricardo C. Abreu; Cristiana V. Ramos; Clarissa Becher; Miguel Lino; Carlos Jesus; Paula A. Costa Martins; Patrícia A. T. Martins; et al. "Exogenous loading of miRNAs into small extracellular vesicles". Journal of Extracellular Vesicles 10 10 (2021): https://doi.org/10.1002%2Fjev2.12111. Published • 10.1002/jev2.12111 Sara Bernardo-Castro; Inês Albino; Ángela María Barrera-Sandoval; Francesca Tomatis; João André Sousa; Emanuel Martins; Susana Simões; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. https://doi.org/10.3390%2Flife11060482. 10.3390/life11060482 Francisco, Vitor; Lino, Miguel; Ferreira, Lino. "A near infrared light-triggerable modular formulation for the delivery of small biomolecules". Journal of Nanobiotechnology 17 1 (2019): http://dx.doi.org/10.1186/s12951-019-0530-y. 10.1186/s12951-019-0530-y Helena Henriques-Antunes; Renato M. S. Cardoso; Alessandra Zonari; Joana Correia; Ermelindo C. Leal; Adrián Jiménez-Balsa; Miguel M. Lino; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano (2019): https://doi.org/10.1021/acsnano.9b00376. 10.1021/acsnano.9b00376 Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. https://doi.org/10.1039/C9NR02512J. 10.1039/C9NR02512J Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers". ACS Nano (2018): https://doi.org/10.1021/acsnano.7b07538. 10.1021/acsnano.7b07538 Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira. "Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules". Bioconjugate Chemistry (2018): https://doi.org/10.1021%2Facs.bioconjchem.7b00820. 10.1021/acs.bioconjchem.7b00820 Miguel M. Lino; Lino Ferreira. "Light-triggerable formulations for the intracellular controlled release of biomolecules". Drug Discovery Today (2018): https://doi.org/10.1016%2Fj.drudis.2018.01.019. 10.1016/j.drudis.2018.01.019 Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira. "Intracellular delivery of more than one protein with spatio-temporal control". Nanoscale (2017): https://doi.org/10.1039/C7NR02414B. 10.1039/C7NR02414B Miguel M. Lino; Cristiana S.O. Paulo; Ana C. Vale; M. Fátima Vaz; Lino S. Ferreira. "Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles". Dental Materials 29 10 (2013): e252-e262. https://doi.org/10.1016%2Fj.dental.2013.07.023. 10.1016/j.dental.2013.07.023 Lino, Miguel. "Differential internalization of amphotericin B – Conjugated nanoparticles in human cells and the expression of heat shock protein 70". Biomaterials 34 21 (2013): 5281-5293. http://www.sciencedirect.com/science/article/pii/S014296121300358X. https://doi.org/10.1016/j.biomaterials.2013.03.048 D. Botequim; J. Maia; M. M. F. Lino; L. M. F. Lopes; P. N. Simões; L. M. Ilharco; L. Ferreira. "Nanoparticles and Surfaces Presenting Antifungal, Antibacterial and Antiviral Properties". Langmuir 28 20 (2012): 7646-7656. https://doi.org/10.1021%2Fla300948n. 10.1021/la300948n
Thesis / Dissertation	Lino, Miguel. "Light-triggerable nanomaterials for the delivery of biomolecules". PhD, Universidade de Coimbra, 2017.

Intellectual property

Patent

Lino, Miguel. 2017. "composition for controlled release of a biomolecule, method of preparation and uses thereof". Portugal.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/09	Engineering of extracellular vesicles for tissue engineering	33rd Annual Conference of the European Society for Biomaterials (Davos)
2023/05/12	Engineered extracellular vesicles for the treatment of ischemic diseases (Invited Speaker)	Workshop - ICNAS Pharma ICNAS (Coimbra, Portugal)
2022/06/10	Extracellular vesicles secreted by mononuclear cells from umbilical cord blood induce neuroprotection and angiogenesis and attenuate microglia reactivity in a mouse model of brain ischemia	ESCI 2022 European Society for Clinical Investigation (Bari, Italy)
2022/05/27	Engineered extracellular vesicles targeting the ischemic myocardium (Invited speaker)	8th COST Action CardioRNA MC and WG Meeting COST Action CardioRNA (Pavia, Italy)
2022/03/11	Engineering strategies to boost the therapeutic potential of extracellular vesicles (Invited speaker)	XII International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Braga)
2021/03/04	Light-controlled delivery of biomolecules (Invited speaker)	XVI ENEEB - National Biomedical Engineering Student Symposium (Portugal)
2020/07/15	Advanced formulations for the delivery of biomolecules (Invited speaker)	2nd NanoStem Summer School University of Coimbra (Coimbra, Portugal)
2019/12/19	Modulation of microRNA Delivery with Light (Invited speaker)	CiBB meeting 2019 CiBB (Coimbra, Portugal)
2019/07	Controlled release of small extracellular vesicles by a light-triggerable hydrogel improves diabetic wound healing	Controlled Release Society, Annual Meeting and Exposition CRS (Valência, Spain)
2019/05	Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel	53rd Annual Scientific Meeting of the European Society for Clinical Investigation ESCI (Coimbra, Portugal)
2019/05	What is needed from preclinical research to set up a clinical trial (Invited speaker)	53rd Annual Scientific Meeting of the European Society for Clinical Investigation ESCI (Coimbra, Portugal)
2019/05	PET imaging and in vivo biodistribution of small extracellular vesicles	53rd Annual Scientific Meeting of the European Society for Clinical Investigation ESCI (Coimbra, Portugal)
2019/01/19	Controlled drug release systems	Advanced workshop on biotechnology Instituto de Educação e Cidadania (Portugal)
2018/12	Improved wound healing activity of small extracellular vesicles loaded in a light-triggerable hydrogel	Secretome Without Borders (Braga, Portugal)
2018	Controlling drug delivery with light (Invited speaker)	IV Symposium of the Doctoral Program on Molecular and Environmental Biology, (Braga, Portugal)
2016/07	Light controlled protein delivery	German-Portuguese Student Workshop within the DAAD-Programme “Dialogue with Institutions of Higher Education in Southern Europe” Biomaterials and Stem Cell based therapeutics Lab (Cantanhede, Portugal)
2016/05	Modulating protein delivery by opto-nanomedicine	10th World Biomaterials Congress, (Montreal, Canada)
2015/10	Modulating cell activity by opto-nanomedicine	9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (Oeiras, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2022/09 - Current	Combinatorial intervention to treat myocardial infarction Co-supervisor of Ana Carolina Mendes
2018/09/01 - Current	New platforms for brain targeting by extracellular vesicles Co-supervisor of Inês Maria Cunha Albino	Universidade de Coimbra, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/09/08 - Current	Symposium "Extracellular Vesicle Bioengineering", 33rd Annual Conference of the European Society for Biomaterials, Davos, 2023 (Keynote speaker) (2023/09/08) Symposium (Co-organisor)
2016/06/27 - Current	Stem cell workshop: from basic research to clinical applications, Centro Hospitalar da Universidade de Coimbra, Portugal, June 27 th 2016. (2016/06/27) Workshop (Member of the Organising Committee)
2023/12/06 - 2023/12/07	3rd RESET Ageing conference (2023/12/06 - 2023/12/07) Conference	Universidade de Coimbra, Portugal
2021/06/30 - 2021/06/30	1st RESETageing conference (2021/06/30) Conference (Member of the Organising Committee)
2019/06/28 - 2019/06/29	Conference: Ageing, models mechanisms and therapies. Responsible for the dissemination of the event in the media. (2019/06/28 - 2019/06/29) Conference (Member of the Organising Committee)	Universidade de Coimbra, Portugal
2018/07/27 - 2018/07/27	Workshop on “Ageing: models and therapies”, Faculty of Medicine, University of Coimbra, Polo III, June 27 th , 2018. (2018/07/27) Workshop (Member of the Organising Committee)	Universidade de Coimbra, Portugal
2016/07/07 - 2016/07/08	German-Portuguese student Workshop on “Translation in Biomaterials and Stem Cell Research”, Biocant, Cantanhede, Portugal, July 7-8 2016. The event was organized in collaboration with Dr. Tilo Pompe from the University of Leipzig, Germany, and funded by the DAAD program “Dialogue with Institutions of Higher Education in Southern Europe”. (2016/07/07 - 2016/07/08) Workshop	Universidade de Coimbra, Portugal
2014/03/24 - 2014/03/24	Workshop on Stem cells: from basic research to therapeutic applications, Centro do Sangue e Transplantação de Coimbra, Coimbra, Portugal, March 24 th , 2014. (2014/03/24 - 2024/03/24) Workshop (Co-organisor)
2013/12 - 2013/12	German-Portuguese student Workshop on “Matrix Engineering meets Stem Cell Therapy”, Biocant, Cantanhede, Portugal, December 2013. (2013/12 - 2013/12) Workshop (Co-organisor)
2013/07/19 - 2013/07/19	First International Conference on Stem Cells for Drug Screening and Regenerative Medicine, Biocant, Cantanhede, Portugal, July 19 th , 2013. The meeting had the contribution of renowned speakers including Jeffrey Karp (Harvard University), Molly Stevens (Imperial College of London), Pedro Granja (INEB, University of Porto, Portugal), Stephen Minger (GE Healthcare, UK), Tim Allsop (Pfizer), Joaquim Cabral (IST, Portugal), Constanza Emanueli (University of Bristol), Marc Peschanski (I-STEM) and Ihor Lemischka (Mount Sinai School of Medicine). (2013/07/19 - 2013/07/19)

Event participation

	Activity description Type of event	Event name Institution / Organization
2016/07/18 - 2016/07/22	Building Global innovators (Innovation accelerator) – Entrepreneurship course Other	Building Global Innovators ISCTE Business School, Portugal
2015/10/05 - 2015/10/09	Quantitative Fluorescence Microscopy Course Workshop	Quantitative Fluorescence Microscopy Course CNC.IBILI, Portugal
2009/11/02 - 2009/11/07	7th International Stem Cell School in Regenerative Medicine Workshop

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2024/10/07	Transport of modulated extracellular vesicles transfected with microRNAs to the heart (Thesis) Main arguer	Ana Sofia Menezes de Sousa (Master) Universidade de Coimbra, Portugal
2024/09/26	Targeting extracellular vesicles to ischemic endothelial cells (Thesis) Main arguer	André Esperança (Master) Universidade de Coimbra, Portugal
2024/09/23	Exploring The Potential Of Iron Oxide Nanoparticles In Ultrasound For Glioblastoma Therapy (Thesis) Main arguer	Joel Sérgio Jesus Barcelos (Master) Universidade de Coimbra, Portugal
2023/07/05	MicroRNAs-enriched exosomes as a new therapy for Parkinson’s disease. (Thesis) Main arguer	Marta Carrola Esteves (PhD) Universidade da Beira Interior, Portugal
2023/04/06	Synaptic regulation by chronic stress-induced microRNAs (Thesis) Arguer	Beatriz Figueired Rodrigues (PhD) Universidade de Coimbra, Portugal
2022/09/30	Radiolabelling of Small Extracellular Vesicles for Diagnostics and Therapeutic Applications (Thesis) Main arguer	Francisco Tejo (Master) Universidade de Coimbra, Portugal
2022/09/23	Nanoformulations for the treatment of vascular ageing (Thesis) Main arguer	Joana Padrão (Master) Universidade de Coimbra, Portugal
2022/03/30	Vascular cell senescence: Triggers and therapeutic strategies (Thesis) Arguer	Rita Sá Ferreira (PhD) Universidade Nova de Lisboa, Portugal
2021/01/11	Biocompatible Nanoparticles to Modulate Cell Activity (Thesis) Arguer	Josephine Blersch (PhD) Universidade de Coimbra, Portugal
2018/12	Funcionalização de filmes finos plasmónicos de Au-TiO2 com elementos de bioreconhecimento para deteção de biomoléculas (Thesis) Main arguer	Diana Isabela Faria Meira (Master) Universidade do Minho, Portugal
2018/12	Development of ZnO thin films for antimicrobial applications (Thesis) Main arguer	Patrícia Alexandra Pereira da Silva (Master) Universidade do Minho, Portugal

Association member

	Society Organization name	Role
2017/10 - Current	Controlled Release Society

Committee member

	Activity description Role	Institution / Organization
2019/07 - Current	Coordinator of the section Stem Cells and Tissue Engineering Coordinator

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2018/09/01 - Current	Regenerative Medicine	Ciências de Engenharia Biomédica (Licenciatura)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/01/12 - 2020/03/16	Biotechnology and Regenerative Medicine	(Outros)	Instituto de Educação e Cidadania, Portugal

Interview (tv / radio show)

	Program	Topic
2019/01/29 - 2019/01/29	Rádio França Internacional - Magazine de Ciência

Mentoring / Tutoring

	Topic	Student name
2024/09 - Current	Development of ex vivo cardiac models	Filipa Ferreira
2022/12/01 - Current	Extracellular vesicles to reverse cell senescence	Cláudia Deus (Postdoctoral researcher)
2022/03 - Current	Study of anti-senescence properties of extracellular vesicles	Susana Soares (MSc fellow)
2022/02/01 - Current	Neuroregeneration mechanisms of extracellular vesicles	Magda Rodrigues (MSc felllow)
2022/07/01 - 2022/08/31	Extracellular vesicles targeting ischemic endothelial cells	Juliana Floriano (Visiting postdoctoral researcher)
2022/06 - 2022/08	Interaction of nanogels with the blood brain barrier	Roberta Bilardo (Visiting PhD student from Queen Mary University of London)
2020/11 - 2021/11		Inês Aires
2021/01 - 2021/04	Production and characterization of extracellular vesicles	João Novo (MSc fellow)
2018/01/01 - 2021/03/31	Extracellular vesicles to treat brain ischemia	Tiago Rondão (MSc fellow)
2020/07/01 - 2020/09/30	Functionalization of gold nanorods	Natália Ferrari (Visiting MSc student)
2020/05/01 - 2020/09/30	Production of extracellular vesicles	Clarissa Becher (MSc fellow)
2019/09/01 - 2020/03/31	Extracellular vesicles for the treatment of ischemic stroke	Inês Morais (MSc fellow)
2020/01 - 2020/02	Cell culture; extracellular vesicle isolation and characterization	Diana Pereira Gonçalves (Visiting undergraduate student)
2019/09/01 - 2019/10/01	Modification of extracellular vesicles with targeting peptides	Francesco Catapano (visiting postdoctoral researcher)
2018/05/01 - 2018/05/31	Exosome isolation, characterization and modification strategies	Luís Oliveira (MSc student)

Distinctions

Award

2023	Best poster - Joint Meeting of the ETRS & SPCE-TC, Coimbra, 2023
2023	Best poster - 2nd PNEV meeting, Lisbon, 2023
2022	Best poster award Meeting on Biosystems in Toxicology and Pharmacology , Portugal
2017	Best Poster Prize CESB, Portugal
2017	Best Poster Prize Sociedade Portuguesa de Células Estaminais e Terapias Celulares, Portugal

Other distinction

2022	Mobility grant COST, European Cooperation in Science and Technology, Belgium
2021	Mobility grant COST, European Cooperation in Science and Technology, Belgium
2021	FCT Scientific Employment Stimulus Awardee Fundação para a Ciência e a Tecnologia, Portugal
2011	PhD scholarship (sfrh/bd/81705/2011) Fundação para a Ciência e a Tecnologia, Portugal
2009	Travel grant - 7th International Stem Cell School in Regenerative Medicine European Union Marie Curie Conferences and Training Courses, Belgium