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Adriana Sánchez-Danés is a Principal Investigator at the Champalimaud Foundation. Her research focusses on cancer and stem cell biology. Her group studies the mechanisms leading to cancer formation, progression and resistance to therapy.
Identification

Personal identification

Full name
Adriana Sánchez-Danés

Citation names

  • Adriana Sánchez-Danés

Author identifiers

Ciência ID
1D11-9F09-9E97
ORCID iD
0000-0001-7895-9973

Email addresses

  • adriana.sanchezdanes@research.fchampalimaud.org (Professional)

Telephones

Telephone
  • 210480141 Ext.: 4408 (Professional)

Addresses

  • Av. Brasilia, 1400-038, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Catalan (Mother tongue)
Spanish; Castilian (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Elementary (A2) Advanced (C1) Elementary (A2) Advanced (C1) Upper intermediate (B2)
French Intermediate (B1) Upper intermediate (B2) Upper intermediate (B2) Advanced (C1) Upper intermediate (B2)
Education
Degree Classification
2008/06/25 - 2012/08/15
Concluded
 PhD in Biomedicine (Doctorat)
Universitat Pompeu Fabra Departament de Ciences Experimentals i de la Salut, Spain
"Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson’s Disease" (THESIS/DISSERTATION)
 Cum laude
2007/09/01 - 2008/06/23
Concluded
 Master in Biomedical Research (Master Universitario)
Universitat Pompeu Fabra Departament de Ciences Experimentals i de la Salut, Spain
"Generation of Dopaminergic neurons from human embryonic stem cells for transplantation therapy in Parkinson’s Disease" (THESIS/DISSERTATION)
2003/09/01 - 2007/06/23
Concluded
 Degree in Biotechnology (Bachelor)
Universitat Autònoma de Barcelona, Spain
Affiliation

Science

Category
Host institution 		Employer
2019/10/01 - Current Principal Investigator (Research) Fundação Champalimaud, Portugal
2012/08/20 - 2019/09/30 Postdoc (Research) Université Libre de Bruxelles - Campus Erasme, Belgium
2011/01/01 - 2012/07/31 Researcher (Research) Universitat de Barcelona Departamento Bioquímica i Biologia Molecular, Spain
2007/09/01 - 2010/12/31 Researcher (Research) Centre de Medicina Regenerativa de Barcelona, Spain
2006/10/01 - 2007/06/15 Research Trainee (Research) Universitat Autònoma de Barcelona Departament d'Enginyeria Química Biològica i Ambiental, Spain
Projects

Grant

Designation Funders
2022/01/01 - Current Combined immUNotherapeutIC approach for targeting bone marrow microenvironment in Multiple Myeloma
PTDC/MED-ONC/1215/2021
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
2022/01/01 - Current Restoring differentiation in cancer cells by manipulating RNA-binding protein NETworks
PTDC/BIA-CEL/0456/2021
Integration into Research Grant Fellow
Fundação para a Ciência e a Tecnologia
2023/01/01 - 2025/12/31 Uncovering the mechanisms of resistance to cancer formation in the developing brain
2022.09083.PTDC
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2024/12/31 Comparing pediatric and adult cancer progression and therapy response
PTDC/MED-ONC/5553/2020
Principal investigator
Fundação para a Ciência e a Tecnologia
2019/10/01 - 2023/09/30 ERA Chair Holder- QuantOCancer Project
Grant agreement No. 810653
Principal investigator
Fundação Champalimaud, Portugal
 European Commission
Ongoing
2020 - 2022 Maratona da Saúde-Janssen Junior Award
Maratona da Saúde Junior award
Principal investigator
2013/10/01 - 2016/09/30 Defining the role of stem cells and progenitors in Basal Cell Carcinoma formation
FNRS-CR 1231214F
Post-doc Fellow
Université Libre de Bruxelles - Campus Erasme, Belgium
 Fonds de la Recherche Scientific
2008/01/01 - 2013/12/31 Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson’s Disease
AP-2007-02226
PhD Student Fellow
Centre de Medicina Regenerativa de Barcelona, Spain

Universitat de Barcelona Departamento Bioquímica i Biologia Molecular, Spain
Gobierno de Espana Ministerio de Educación Cultura y Deporte
Concluded
2007/09/01 - 2008/06/20 Generation of dopaminergic neurons for cell therapy in Parkinson's Disease
FI- AGAUR
Master Student Fellow
Centre de Medicina Regenerativa de Barcelona, Spain
 Generalitat de Catalunya Agència de Gestió d'Ajuts Universitaris i de Recerca
Concluded
2006/10/01 - 2007/06/15 Optimization of processes for obtaining vectors for gene therapy in unconventional bioreactors
BECA Colaboración
Research Fellow
Universitat Autònoma de Barcelona Departament d'Enginyeria Química Biològica i Ambiental, Spain
 Gobierno de Espana Ministerio de Educación Cultura y Deporte
Outputs

Publications

Journal article
  1. Sánchez-Danés, A; Larsimont, JC; Liagre,M; Munoz-Couselo, E; Lapouge, G; Brisebarre, A; Dubois,C; et al. "A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy". Nature (2018): http://dx.doi.org/10.1038/s41586-018-0603-3.
    10.1038/s41586-018-0603-3
  2. Sánchez-Danés, A; Blanpain, C. "Deciphering the cells of origin of squamous cell carcinomas". Nature Reviews Cancer (2018): http://dx.doi.org/10.1038/s41568-018-0024-5.
    10.1038/s41568-018-0024-5
  3. Debaugnies, M; Sánchez-Danés, A; Rorive,S; Raphael, M; Liagre,M; Parent, MA; Brisebarre, A; Salmon,I; Blanpain, C. "YAP and TAZ are essential for basal and squamous cell carcinoma initiation". EMBO reports (2018): http://dx.doi.org/10.15252/embr.201845809.
    10.15252/embr.201845809
  4. Fabienne Lescroart; Xiaonan Wang; Xionghui Lin; Benjamin Swedlund; Souhir Gargouri; Victoria Moignard; Christine Dubois; et al. "Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq". Science 359 6380 (2018): 1177-1181. https://doi.org/10.1126/science.aao4174.
    10.1126/science.aao4174
  5. Sánchez-Danés, A.; Blanpain, C. "Maintaining hair follicle stem cell identity in a dish". The EMBO Journal (2017): http://dx.doi.org/10.15252/embj.201696051.
    10.15252/embj.201696051
  6. Sánchez-Danés, A; Hannezo, E; Larsimont, JC; Liagre,M; Youssef, KK; Simons,BD; Blanpain, C. "Defining the clonal dynamics leading to mouse skin tumour initiation". Nature (2016): http://dx.doi.org/10.1038/nature19069.
    10.1038/nature19069
  7. Fernandez-Santiago, R; Carballo-Carbajal, I; Castellano, G; Torrent,R; Richaud, Y; Sánchez-Danés, A.; Vilarrasa-Blasi, R; et al. "Aberrant epigenome in iPSC -derived dopaminergic neurons from Parkinson's disease patients". EMBO Molecular Medicine (2015): http://dx.doi.org/10.15252/emmm.201505439.
    10.15252/emmm.201505439
  8. Larsimont, JC; Youssef, KK; Sánchez-Danés, A; Sukumaran,V; Defrance,M; Delatte, B; Liagre,M; et al. "Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion". Cell Stem Cell (2015): http://dx.doi.org/10.1016/j.stem.2015.05.008.
    10.1016/j.stem.2015.05.008
  9. Sanchez-Danes, A; Benzoni, P; Memo, M; Dell`Era, P; Raya, A; Consiglio, A. "Induced Pluripotent Stem Cell-Based Studies of Parkinson's Disease: Challenges and Promises". CNS & Neurological Disorders - Drug Targets 999 999 (2013): 29-30. http://dx.doi.org/10.2174/187152731131200128.
    10.2174/187152731131200128
  10. Sánchez-Danés, A; Richaud-Patin, Y; Carballo-Carbajal, I; Jimenez-Delgado, S; Caig, C; Mora, S; Di Guglielmo,C; et al. "Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease". EMBO Molecular Medicine (2012): http://dx.doi.org/10.1002/emmm.201200215.
    10.1002/emmm.201200215
  11. Sánchez-Danés, A.; Consiglio, A.; Richaud, Y.; Rodríguez-Pizà, I.; Dehay, B.; Edel, M.; Bové, J.; et al. "Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells". Human Gene Therapy 23 1 (2012): 56-69. http://dx.doi.org/10.1089/hum.2011.054.
    10.1089/hum.2011.054
  12. Edel, Michael J.; Boue, Stephanie; Menchón, Cristina; Sanchez-Danes, Adriana; Izpisua Belmote, Juan Carlos. "Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development". Cell Cycle 9 17 (2010): 3414-3422. http://dx.doi.org/10.4161/cc.9.17.12719.
    10.4161/cc.9.17.12719
  13. Raya, A; Rodríguez-Pizà, I.; Navarro, S; Richaud-Patin, Y; Guenchea, G; Sánchez-Danés, A; Consiglio, A; Bueren, J; Izpisua Belmonte, J.C.. "A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells". Nature Protocols (2010): http://dx.doi.org/10.1038/nprot.2010.9.
    10.1038/nprot.2010.9
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/10 Defining the tumor cell population responsible for relapse in Basal Cell Carcinoma Champalimaud Research Symposium 2019- Tissue environment in health and disease
2018/07/02 Defining the cell populations responsible for skin cancer initiation and relapse following therapy 25th Biennial Congress of the European Association for Cancer Research (EACR), Amsterdam, Nederlands
2017/11/02 Defining the tumour cell population that mediates skin cancer relapse after therapy 4th Annual Meeting Belgian Society for Stem Cell Research, Liege, Belgium
2015/06/18 Defining the role of stem and progenitor cells during tumour initiation XXIII Porto Cancer Meeting - Stem Cells and Cancer, Porto, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2017/12/01 - 2018/06/01 Organiser of "Pint of Science" Our Body Team- Brussels (2018/05/14 - 2018/05/16)
Conference (Co-organisor)
2015/01/01 - 2017/12/31 Organizer of the weekly Internal Seminars, Interdisciplinary Research Institute, Université Libre de Bruxelles, Belgium (2015/01/01 - 2017/12/31)
Conference (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2014/06/29 - 2014/07/07 64th Lindau Nobel laureate meeting: Physiology and Medicine, Lindau & Mainau Island, Germany
Conference

Association member

Society Organization name Role
2020/01/01 - Current Associação Portuguesa de Investigação em Cancro (ASPIC)
2018/01/01 - Current The European Association for Cancer Research (EACR)
2017/01/01 - Current Member of Asociación Española de Investigación sobre el Cáncer (ASEICA)

Committee member

Activity description
Role 		Institution / Organization
2020/01/01 - Current Member of the work group “ASEICA-joven” and ASEICA Ambassador
Member
2019/11/01 - Current Educational Committee member, Champalimaud Foundation
Member
Distinctions

Award

2024 Liga Portuguesa contra o Cancro Award
2022 AstraZeneca Award in Oncology
AstraZeneca Foundation, Belgium
2020 Maratona de Saude Junior Award
2019 Garrotxina of the year 2018
Centre de Iniciatives Turístiques d'Olot, Spain
2012 PhD thesis “Cum laude” award
Universitat Autònoma de Barcelona, Spain
2008 Awarded the best outstanding academic achievement in Biotechnology- class 2003-2007, awarded by Universitat Autónoma de Barcelona
Fundació Universitat Autónoma de Barcelona, Spain
2008 National prize of excellence for University academic achievement awarded to best outstanding students on the field of Biotechnology, awarded by the Spanish Ministerio de Educación, Cultura y Deporte
Gobierno de Espana Ministerio de Educación Cultura y Deporte, Spain

Title

2018 Ambassador of Olot
Ajuntament d'Olot, Spain