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Current Position: co-head of the Advanced Breast Advanced Innovation Translational Research Lab (ADBCancer Lab). ¿¿ I received a PhD from the Centre d¿Immunologie de Marseille-Luminy (Université de la Méditerranée, France) in 2002, for my studies on antigen delivery on dendritic cells with liposomes for optimal activation of CD4 and CD8 T cells. Then I pursued a post-doctoral training at the MRC Centre for Immune Regulation in the laboratory of Professor Ian MacLennan (University of Birmingham, UK). My work focused on dissecting the molecular determinants governing the emergence of Th2 and TFh cells in vivo in response to immunization with alum-conjugated antigen. In 2011 I joined the laboratory of Bruno Silva-Santos at the Instituto de Medicina Molecular | João Lobo Antunes (Lisbon, Portugal) to study the transcriptional regulation of gd T cells. ¿¿ I am currently a consolidator researcher of the FCT investigator programme, and since 2021 I Co-lead the ADBCancer Lab of the iMM-CARE. We are developing a line of research dedicated on understanding the human breast tumour microenvironment to find innovative ways to control cancer progression and evolution towards metastasis. We aim to find novel molecular mechanisms responsible for therapeutic resistance and therefore contribute to the development of more efficient and specific treatment protocol in breast cancer patients. ¿ In the last 5 years, I have published 13 of my 43 publications, including 3 co-last and co-corresponding author articles in PLoS Biology (IF 9.16), and Journal of Immunology (IF 4.53) and a co-corresponding author review in Nature Reviews Immunology (IF 41.98), besides authorship in Science Immunology, Cancer Immunology Research, and Cardiovascular Research. I have participated in collaborative reviews in Frontiers in Immunology (IF 5.51), and Cancer Immunology and Immunotherapy (IF 4.22), with national collaborators (I3S Porto) and with a European Cost-Action on Myeloid Regulatory Cells (http://www.mye-euniter.eu/) respectively, demonstrating my active dedication to networking activities. ¿ My h factor is 28 and my internationally refereed papers accumulated an impact factor of 237 and have been cited over 3996 times (ResearchGate), and my Research Gate score is 33.54 (higher than 92.5% of RG members). ¿ As a principal investigator, I have been awarded 2 personal fellowships from FCT (investigator FCT); 3 project grants (1*FCT (R&D project), 2*Fundo iMM-Laço), and the Gilead Génese Program award. As co-PI and participant I have been granted 2 FCT project grants. As co-PI I have also received the 1st prize of the 2nd Edition of the Prémio Janssen Inovação. ¿¿ I have been invited to give talks at the international meeting on cancer innovation of the CUF conferences (Porto, Lisbon, 2017) and the European Human Genetics Conference (Gothenburg, Sweden, 2019). I have acted as scientific evaluator for Breast Cancer Now (UK) and Prémios Pfizer to Basic Investigation. I am also a scientific reviewer for EMBO Reports, Scientific Reports, Oncoimmunology, European Journal of Immunology, and PLoS ONE. ¿¿ Since 2023 I am in the committee of the Portuguese Immuno-Oncology SPO-SPI Group. Between 2018-2021, I was a board member of the Portuguese Society of Immunology. ¿¿ I have many activities associated to supervision and teaching, and in 2018 I was recruited as invited Professor Auxiliar in Basic Immunology (at 10% by FMUL). I have been involved in advanced teaching at Universities of Lisbon (PhD LisbonBioMed program, Masters of Oncobiology, and Infectious diseases), and Porto (PhD GABBA program. I have supervised 1 PhD student, and have been a tutor in 4 thesis committees and I have been invited as PhD and MSc examiner at Portuguese academic institutions. I am currently supervising 1 PhD student and co-supervising 3 PhD students and I have also successfully supervised 8 Master and 6 Erasmus students (7 pursuing a PhD)
Read full resume ↓
Identification

Personal identification

Full name
Karine Serre
Gender
Female

Citation names

  • Serre, Karine

Author identifiers

Ciência ID
1E11-7283-DF35
ORCID iD
0000-0001-9152-4739

Email addresses

  • karineserre@medicina.ulisboa.pt (Professional)

Telephones

Telephone
  • 217999549 (Professional)

Addresses

  • Instituto de Medicina Molecular - Joao Lobo Antunes (IMM| JLA), Unit of "T cell Differentiation & Tumor Targeting". Instituto de Medicina Molecular - Joao Lobo Antunes, Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
French (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2002
Concluded
 Immunology (Doutoramento)
Université de la Méditerranée, Aix-Marseille II, France
"Presentation of exogenous antigens by dendritic cells to CD4 and CD8 T cells, in vitro and in vivo" (THESIS/DISSERTATION)
 PhD with honors
1997
Concluded
 DEA Immunology (Diplôme d´études supérieures)
Université de la Méditerranée, Aix-Marseille II, France
"Comparison of presentation of free antigen and liposome-encapsulated antigen, to antigen specific CD4 T cells, by bone marrow-derived dendritic and antigen-specific splenic B cells." (THESIS/DISSERTATION)
 13.89/20 Admitted 7th with 25 candidates
1996
Concluded
 DESS Immuno-Technology (Diplôme d´études supérieures)
Université de la Méditerranée, Aix-Marseille II, France
"Mouse model to study the effect of vaccination with an antigen from Staphylococus aureus to induce protective antibodies against bovine mastitis caused by this pathogen." (THESIS/DISSERTATION)
 12.5/20 Admitted 9th with 12 candidates
1995
Concluded
 Biochemistry and Immunology (Mestrado)
Université de la Méditerranée, Aix-Marseille II, France
"N/A" (THESIS/DISSERTATION)
 13.72/20 Admitted 12th with 66 candidates
1994
Concluded
 Biochemistry (Licence)
Université de la Méditerranée, Aix-Marseille II, France
Affiliation

Science

Category
Host institution 		Employer
2020 - 2026 Principal Investigator (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2015/01/01 - 2019/12/31 Principal Investigator (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2012/01/01 - 2014/12/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2002 - 2011 Postdoc (Research) Birmingham MRC Centre for Immune Regulation, United Kingdom
Birmingham MRC Centre for Immune Regulation, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2018/11/02 - 2020/11/02 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina, Portugal
Instituto de Medicina Molecular, Portugal
Projects

Grant

Designation Funders
2021/06/01 - Current Regulation of gamma-delta T cells in the tumor microenvironment and their manipulation towards immunotherapy of solid cancers (250,000¿)
PTDC/MED-ONC/6829/2020
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 Dissect the tumor microenvironment to battle cancer radioresistance and immune escape
PTDC/MED-ONC/4165/2021
10.54499/PTDC/MED-ONC/4165/2021
Fundação Champalimaud, Portugal

Universidade Nova de Lisboa, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Centro Hospitalar Universitário de São João, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021 - 2024 Regulation of gamma-delta T cells in the tumor microenvironment and their manipulation towards effective immunotherapy of solid cancers. Co-PI. (250,000 E).
PTDC/MED-ONC/6829/2020
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 MAGICIAM: a MAcrophaGe Immunomodulatory-delivery system to prevent Cancer Invasion And Metastasis. (238,554€ - of which 12.500€ for iMM).
PTDC/BMT-SAL/031859/2017
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Sub-therapeutic doses of ionizing radiation modulate the pre-metastatic niche and induce metastasis. Co-PI. (239,925 E).
PTDC/MED-OUT/031118/2017
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Programming anti-tumour myeloid cells to improve cancer immunotherapies. (239,896€).
PTDC/MED-IMU/30948/2017
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Sub-therapeutic doses of ionizing radiation modulate the pre-metastatic niche and induce metastasis. Co-PI. (239,925 E).
PTDC/MED-OUT/031118/2017
 Fundação para a Ciência e a Tecnologia
2017 - 2019 Sulfur-containing amino acid dietary modulation of breast cancer immunity. (€25,000).
Fundo iMM-Laço 2017-02
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundo iMM-Laço
Concluded
2016 - 2018 Transcriptional (re)programming of antitumour myeloid cells in breast cancer. (€50,000).
Fundo iMM-Laço 2016-03
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundo iMM-Laço
Concluded
2011 - 2011 Identification of a key molecule for the differentiation of CD4 T helper 2 (Th2) cells and follicular T helper (TFh) cells in vivo. (£2,195).
University of Birmingham Research Development Fund
Principal investigator
Birmingham MRC Centre for Immune Regulation, United Kingdom
 Birmingham MRC Centre for Immune Regulation
Concluded
2011 - 2011 Identification of a key molecule for the differentiation of CD4 T helper 2 (Th2) cells and follicular T helper (TFh) cells in vivo. (£2,195).
University of Birmingham Research Development Fund
 Birmingham MRC Centre for Immune Regulation
2004 - 2009 Regulation of extrafollicular antibody responses and plasma cell survival. (£1,218,000).
British Medical Research Council
Researcher
University of Birmingham College of Medical and Dental Sciences, United Kingdom
 Medical Research Council
Concluded
2006 - 2007 Extending the scope of single cell analysis of regulation of Th2-cytokine clustered genes among CD4 T helper cells. (£4,000).
University of Birmingham Scientific Projects Committee grant
Principal investigator
Birmingham MRC Centre for Immune Regulation
Concluded
2006 - 2007 Extending the scope of single cell analysis of regulation of Th2-cytokine clustered genes among CD4 T helper cells. (£4,000).
University of Birmingham Scientific Projects Committee grant
 Birmingham MRC Centre for Immune Regulation

Contract

Designation Funders
2020 - 2025 Bringing new allies to cancer therapy: How to instruct tumour-infiltrating myeloid cells to fight cancer?
CEECIND/00697/2018
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 combined immUNotherapeutIC approach for targeting bone marrow microenvironment in Multiple Myeloma
PTDC/MED-ONC/1215/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa, Portugal

Fundação Champalimaud, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 X-Chromosome Inactivation in Systemic Lupus Erythematosus
EXPL/MED-OUT/1517/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/15 - 2021/10/14 MAGICIAM: um sistema imunomodelador de macrófagos para prevenir a invasão e metastização das células tumorais
PTDC/BTM-SAL/31859/2017
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2020 Lineage-specific molecular networks that control production of pathogenic cytokines. (€180,000 for personal salary and €50,000 for the research project).
IF/00004/2014/CP1236/CT0006
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011 - 2015 Intrinsic and extrinsic molecular controls of “inducible” versus “constitutive” production of IFN-g and IL-17 in TCRab CD4+ and TCRgd T cells in vivo. (€53,820).
SFRH/BPD/78039/2011.
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2010 Identifying novel transcription factors that drive CD4 T helper 2 cell differentiation in vivo. (£27,000).
Wellcome Trust Value in People Fellowship Bridging Award
Principal investigator
Birmingham MRC Centre for Immune Regulation, United Kingdom
 Wellcome Trust
Concluded
2009 - 2010 Identifying novel transcription factors that drive CD4 T helper 2 cell differentiation in vivo. (£27,000).
Wellcome Trust Value in People Fellowship Bridging Award
 Birmingham MRC Centre for Immune Regulation
2000 - 2001 Exogenous antigen presentation by dendritic cells to CD4 and CD8 T cells, in vitro and in vivo. (€13,719).
ssociation Pour la Recherche sur le Cancer (ARC)
PhD Student Fellow
Fondation ARC pour la Recherche sur Le Cancer, France
 Fondation ARC pour la Recherche sur Le Cancer
Concluded
2000 - 2001 Exogenous antigen presentation by dendritic cells to CD4 and CD8 T cells, in vitro and in vivo. (¿13,719).
ssociation Pour la Recherche sur le Cancer (ARC)
 Fondation ARC pour la Recherche sur Le Cancer
1997 - 2000 Etude des propriété de présentation antigénique par les cellules dendritiques dérivées de la moelle osseuse in vitro. (€ 37,800).
MNRT-13-1996
PhD Student Fellow
Aix-Marseille Université, France
 Gouvernement francais Ministere de l'education nationale
Concluded
Outputs

Publications

Book chapter
  1. Ribot, Julie C.; Serre, Karine; Silva-Santos, B.. "Developmental and Functional Assays to Study Murine and Human gd T Cells". In Methods inMolecular Biology, 257-267. Springer New York., 2017.
  2. MacLennan, Ian; Serre, Karine; Mohr, Elodie. "Lymph nodes and the spleen; critical microenvironments in lymphomagenesis". In The Lymphoid Neoplasms, 3rd Edition, Edited by Ian T. Magrath.. 2009.
    10.1201/b13424-16
Conference paper
  1. Castro, Flávia; Marta Laranjeiro Pinto; Andreia Machado Silva; Catarina Leite Pereira; Olivier de Wever; Serre, Karine; Raquel Madeira Gonçalves; Maria José Oliveira. "Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy". Paper presented in 8th International conference on Tumor Microenvironment: Progression, Therapy & Prevention, Lisboa, 2018.
    Published
Conference poster
  1. VALDOLEIROS, MARIA; Melo, Carolina; Santos, Mafalda; Martins, Elisabete; Almeida, Ana M.; Ramirez, Mário; Costa, Luís; et al. "Microbiota: a new player in breast tumour microenvironment?". Paper presented in III ASPIC-ASEICA International Meeting ¿ Cancer Immunology, Tumor Microenvironment and Metastasis, 2023.
  2. Lopes, Raquel; Diana Lourenço; Caetano, Joana; Ana Filipa Barahona Afonso; Velosa Ferreira, Bruna; QUEIRÓS, ANA; Arnault Carneiro, Emilie; Serre, Karine; Cristina João. "It takes two to tango: multiple myeloma and bone marrow immune cells". Paper presented in 16th ENII EFI EJI Summer School on Advanced Immunology, 2023.
  3. Santos, Mafalda; VALDOLEIROS, MARIA; Serre, Karine; Dias, Sérgio. "Tissue-resident microbiota: a new player in breast cancer aggressiveness". 2023.
  4. Ana Raquel lopes; Caetano, Joana; Ana Filipa Barahona; Velosa Ferreira, Bruna; Diana Lourenço; Ana C. Queirós; Matthiesen, Rune; et al. "Insights on how multiple myeloma-derived extracellular vesicles modulate the bone marrow immune niche". Paper presented in XLVIII Annual Meeting Portuguese Socienty of Immunology, 2023.
  5. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; Matthiesen, Rune; et al. "Insights on how multiple myeloma-derived extracellular vesicles modulate the bone marrow niche". Paper presented in XLVIII Annual Meeting Portuguese Society of Immunology, 2023.
  6. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; et al. "Are you talking to me? How multiple myeloma-derived extracellular vesicles reprogramme the bone marrow immune niche". Paper presented in Champalimaud Research Symposium, 2022.
  7. Pereira da Silva, Sara; De Niz, Mariana; Serre, Karine; Ouarné, Marie; Franco, Claudio A.; Figueiredo, Luisa M.. "Trypanosome sequestration and immune response drive acute cerebral disease.". Paper presented in Kinetoplastid Molecular Cell Biology Meeting., 2022.
  8. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; et al. "Unraveling the crosstalk beterrn multiple myeloma and the bone marrow immune microenvironment: a role for myeloma-derived extracellular vesicles?". Paper presented in XV CAML V NeurULisboa PhD Students meeting, 2022.
  9. Castro, Flávia; Serre, Karine; Fátima Gartner; Raquel Madeira Gonçalves; Olivier de Wever; Maria José Oliveira. "Chitosan/y-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer". Paper presented in Conference Cancer Biology: From Basic to Translational Research (Webinar), 2020.
  10. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Gartner, Fátima; Serre, Karine; Barbosa, Mário A.; Gonçalves, Raquel M.; de Wever, Olivier; Oliveira, Maria J. "Re-educating the tumor immune landscape: chitosan and poly(y-glutamic acid) nanoparticles in sight". Paper presented in XLV Annual Meeting Sociedade Portuguesa de Imunologia (SPI) - Leaping forward translational immunology | Coimbra, Portugal, 2019.
  11. Castro, Flávia; Marta Laranjeiro Pinto; Leite Pereira, Catarina; Serre, Karine; Fátima Gartner; Mário Adolfo Barbosa ; Olivier de Wever; Raquel Madeira Gonçalves; Maria José Oliveira. "Chitosan/poly(y-glutamic acid) nanoparticles and radiotherapy: a winning combination to fight cancer". Paper presented in ASPIC International Meeting ¿ Current Trends in Immunotherapy Research and Treatment, Salamanca, Spain, 2019.
  12. Castro, Flávia; Marta Laranjeiro Pinto; Leite Pereira, Catarina; Serre, Karine; Fátima Gartner; Mário Adolfo Barbosa ; Olivier de Wever; Raquel Madeira Gonçalves; Maria José Oliveira. "Reprogramming the breast tumor microenvironment: chitosan and poly(y-glutamic acid) nanoparticles in sight". Paper presented in 26th Porto Cancer Meeting: The Cancer Ecosystem: From Research to Pathology and Treatment, 2019.
  13. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Barbosa, Mário A.; de Wever, Olivier; Serre, Karine; Goncalves, Raquel M.; Oliveira, Maria J.. "Reprogramming antigen-presenting cells: a chitosan/pga nanoparticles for immunomodulatory therapy". Paper presented in Oncopoint 2018 | Ghent, Belgium, 2018.
  14. Gomes, AQ; Schmolka, N; Serre, Karine; SILVA-SANTOS, Bruno. "Epigenetic and transcripitional regulation of IL17 and IFNg expression during gd T cell differentiation.". Paper presented in IL-17 and related cytokines conference, 2012.
Journal article
  1. Chora, Ângelo Ferreira; Marques, Sofia; Gonçalves, Joana Lisboa; Lima, Priscila; Gomes da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria Inês; et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via gd T cells and IL-17-promoted stress erythropoiesis". Immunity 56 3 (2023): 592-605.e8. http://dx.doi.org/10.1016/j.immuni.2023.01.031.
    Published • 10.1016/j.immuni.2023.01.031
  2. Lopes, Raquel; Caetano, Joana; Barahona, Filipa; Pestana, Carolina; Ferreira, Bruna Velosa; Lourenço, Diana; Queirós, Ana C.; et al. "Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune Microenvironment". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.909880.
    Published • 10.3389/fimmu.2022.909880
  3. Mukherjee, Debanjan; Chora, Ângelo Ferreira; Lone, Jean-Christophe; Ramiro, Ricardo S.; Blankenhaus, Birte; Serre, Karine; Ramirez, Mário; et al. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome". Nature Communications 13 1 (2022): http://dx.doi.org/10.1038/s41467-022-31301-8.
    Published • 10.1038/s41467-022-31301-8
  4. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Bruna Velosa Ferreira; Diana Lourenço; QUEIRÓS, ANA; et al. "Multiple myeloma-derived extracelular vesicles modulate the bone marrow immune microenvironment.". Frontiers in Immunology (2022): https://doi.org/10.3389/fimmu.2022.909880.
    Published
  5. De Niz, Mariana; Silva Pereira, Sara; Serre, Karine; Ouarné, Marie; Coelho, Joana E; Franco, Claudio; Figueiredo, Luisa M.. "Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis". (2022): http://hdl.handle.net/10451/55386.
    10.7554/eLife.77440
  6. Machado, Henrique; Bizarra-Rebelo, Tiago; Costa-Sequeira, Mariana; Trindade, Sandra; Carvalho, Tânia; Rijo-Ferreira, Filipa; Rentroia-Pacheco, Barbara; Serre, Karine; Figueiredo, Luisa M.. Corresponding author: Serre, Karine. "Trypanosoma brucei triggers a broad immune response in the adipose tissue". PLOS Pathogens 17 9 (2021): e1009933. http://dx.doi.org/10.1371/journal.ppat.1009933.
    Open access • Published • 10.1371/journal.ppat.1009933
  7. Reis-Sobreiro, Mariana; Teixeira da Mota, Afonso; Jardim, Carolina; Serre, Karine. Corresponding author: Serre, Karine. "Bringing Macrophages to the Frontline against Cancer: Current Immunotherapies Targeting Macrophages". Cells 10 9 (2021): 2364. http://dx.doi.org/10.3390/cells10092364.
    Open access • Published • 10.3390/cells10092364
  8. Meireles, Patrícia; Brás, Daniela; Fontinha, Diana; Chora, Ângelo F.; Serre, Karine; Mendes, António M.; Prudêncio, Miguel. "Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation". iScience 23 12 (2020): 101781. http://dx.doi.org/10.1016/j.isci.2020.101781.
    10.1016/j.isci.2020.101781
  9. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Barbosa, Mário A.; Vermaelen, Karim; Gärtner, Fátima; et al. "Chitosan/g-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer". Biomaterials 257 (2020): 120218. http://dx.doi.org/10.1016/j.biomaterials.2020.120218.
    10.1016/j.biomaterials.2020.120218
  10. Alves, Nuno L.; Carvalho, Agostinho; Serre, Karine; Martins, Vera C.; Saraiva, Margarida. "The Portuguese Society for Immunology (SPI): history and mission". European Journal of Immunology 50 7 (2020): 918-920. http://dx.doi.org/10.1002/eji.202070075.
    10.1002/eji.202070075
  11. Umansky, V.; Adema, G.J.; Baran, J.; Brandau, S.; Van Ginderachter, J.A.; Hu, X.; Jablonska, J.; et al. "Interactions among myeloid regulatory cells in cancer". Cancer Immunology, Immunotherapy 68 4 (2018): 645-660. http://dx.doi.org/10.1007/s00262-018-2200-6.
    Published • 10.1007/s00262-018-2200-6
  12. Mensurado, S.; Rei, Margarida; Lança, T.; Ioannou, M.; Gonçalves-Sousa, N.; Kubo, H.; Malissen, M.; et al. Corresponding author: Serre, K.. "Tumor-associated neutrophils suppress pro-tumoral IL-17+ gd T cells through induction of oxidative stress". PLOS Biology 16 5 (2018): e2004990. http://dx.doi.org/10.1371/journal.pbio.2004990.
    Published • 10.1371/journal.pbio.2004990
  13. Schmolka, N.; Papotto, P.H.; Romero, Vargas, P.; Amado, T.; Enguita, F.J.; Amorim, A.; Rodrigues, A.F.; et al. "MicroRNA-146a controls functional plasticity in gd T cells by targeting NOD1". Science Immunology 3 23 (2018): eaao1392. http://dx.doi.org/10.1126/sciimmunol.aao1392.
    Published • 10.1126/sciimmunol.aao1392
  14. Castro, F.; Cardoso, A.P.; Gonçalves, R.M.; Serre, K.; Oliveira, M.J.. "Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion". Frontiers in Immunology 9 (2018): 847. http://dx.doi.org/10.3389/fimmu.2018.00847.
    Published • 10.3389/fimmu.2018.00847
  15. Kubo, H.; Mensurado, S.; Gonçalves-Sousa, N.; Serre, K.; Silva-Santos, B.. "Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.". Cancer immunology research 5 9 (2017): 812-820. http://europepmc.org/abstract/med/28811289.
    Published • 10.1158/2326-6066.cir-17-0082
  16. Ministro, A; de Oliveira, P.; Nunes, R.J.; Dos Santos Rocha, A; Correia, A.; Carvalho, T.; Rino, J.; et al. "Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia.". Cardiovascular research 113 7 (2017): 783-794. http://europepmc.org/abstract/med/28444128.
    Published • 10.1093/cvr/cvx065
  17. Ribot, J.C.; Serre, K.; Silva-Santos, B.. "Developmental and Functional Assays to Study Murine and Human gd T Cells.". Methods in molecular biology 1514 (2017): 257-267. http://europepmc.org/abstract/med/27787805.
    Published • 10.1007/978-1-4939-6548-9_18
  18. Barros-Martins, J.; Schmolka, N.; Fontinha, D.; Pires de Miranda, M.; Simas, J.P.; Brok, I.; Ferreira, C.; et al. Corresponding author: Serre, K.. "Effector gd T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors". The Journal of Immunology 196 9 (2016): 3642-3652. https://doi.org/10.4049/jimmunol.1501921.
    Published • 10.4049/jimmunol.1501921
  19. Silva-Santos, B.; Serre, K.; Norell, H.. "gd T cells in cancer". Nature Reviews Immunology 15 (2015): 683-691. http://europepmc.org/abstract/med/26449179.
    Published • 10.1038/nri3904
  20. Flores-Langarica, A.; Bobat, S.; Marshall, J.L.; Yam-Puc J.C.; Cook, C.N.; Serre, K.; Kingsley, R.A.; et al. "Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production.". European journal of immunology 45 8 (2015): 2299-2311. http://europepmc.org/abstract/med/26036767.
    Published • 10.1002/eji.201545564
  21. Serre, K.; Schmolka, N.; Grosso, A.R.; Rei, M.; Pennington, D.J.; Gomes, A.Q.; Silva-Santos, B.. "Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gd T cell subsets". Nature Immunology 14 10 (2013): 1093-1100. http://dx.doi.org/10.1038/ni.2702.
    Published • 10.1038/ni.2702
  22. Serre, K.; Silva-Santos, B.. "Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory gd T Cell Subsets". Frontiers in Immunology 4 (2013): http://dx.doi.org/10.3389/fimmu.2013.00431.
    Published • 10.3389/fimmu.2013.00431
  23. Serre, K.; Cunningham, A.F.; Coughlan, R.E.; Lino, A.C.; Rot, A.; Hub, E.; Moser, K.; et al. "CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines". Blood 120 23 (2012): 4552-4559. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870491540&partnerID=MN8TOARS.
    Published • 10.1182/blood-2012-03-417733
  24. Serre, Karine; Mohr, E.; Bénézech, C.; Bird, R.A.; Khan, M.; Caamaño, J.H.; Cunningham, A.F.; MacLennan, I.C.M.. "Selective effects of NF-kB1 deficiency in CD4+ T cells on Th2 and TFh induction by alum-precipitated protein vaccines". European Journal of Immunology 41 6 (2011): 1573-1582. https://www.ncbi.nlm.nih.gov/pubmed/21469117.
    Published • 10.1002/eji.201041126
  25. Bobat, Saeeda; Flores-Langarica, Adriana; Hitchcock, Jessica; Marshall, Jennifer L.; Kingsley, Robert A.; Goodall, Margaret; Gil-Cruz, Cristina; et al. "Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection". European Journal of Immunology 41 6 (2011): 1606-1618. http://dx.doi.org/10.1002/eji.201041089.
    Published • 10.1002/eji.201041089
  26. Serre, K.; Bénézech, C.; Desanti, G.; Bobat, S.; Toellner, K.-M.; Bird, R.A.; Chan, S.; et al. "Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression". PLoS ONE 6 6 (2011): e20731. https://www.ncbi.nlm.nih.gov/pubmed/21677778.
    Published • 10.1371/journal.pone.0020731
  27. Mohr, E.; Cunningham, A.F.; Toellner, K.-M.; Bobat, S.; Coughlan, R.E.; Bird, R.A.; MacLennan, I.C.M.; Serre, K.. "IFN-g produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine". Proceedings of the National Academy of Sciences of the United States of America 107 40 (2010): 17292-17297. http://www.scopus.com/inward/record.url?eid=2-s2.0-78049248431&partnerID=MN8TOARS.
    Published • 10.1073/pnas.1004879107
  28. Bénézech, C.; White, A.; Mader, E.; Serre, K.; Parnell, S.; Pfeffer, K.; Ware, C.F.; Anderson, G.; Caamaño, J.H.. "Ontogeny of stromal organizer cells during lymph node development". Journal of Immunology 184 8 (2010): 4521-4530. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952787146&partnerID=MN8TOARS.
    Published • 10.4049/jimmunol.0903113
  29. Serre, K.; Mohr, E.; Gaspal, Fabrina; Lane, P.J.L.; Bird, R.A.; Cunningham, A.F.; MacLennan, I.C.M.. "IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo". Molecular Immunology 47 10 (2010): 1914-1922. http://dx.doi.org/10.1016/j.molimm.2010.03.010.
    Published • 10.1016/j.molimm.2010.03.010
  30. Serre, K.; Mohr, E.; Toellner, K-M.; Cunningham, A.F.; Bird, R.A.; Khan, M.; MacLennan, I.C.M.. "Cover Picture: Eur. J. Immunol.". European Journal of Immunology 39 6 (2009): 1436-1436. http://dx.doi.org/10.1002/eji.200990028.
    Published • 10.1002/eji.200990028
  31. Mohr, E.; Serre, K.; MacLennan, I.. "Response to the comments on "Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironment where plasmablasts mature"". Journal of Immunology 182 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77951716962&partnerID=MN8TOARS.
    Published • 10.4049/jimmunol.0990034
  32. Mohr, E.; Serre, K.; Manz, R.A.; Cunningham, A.F.; Khan, M.; Hardie, D.L.; Bird, R.; MacLennan, I.C.M.. "Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature". Journal of Immunology 182 4 (2009): 2113-2123. http://www.scopus.com/inward/record.url?eid=2-s2.0-61449162967&partnerID=MN8TOARS.
    Published • 10.4049/jimmunol.0802771
  33. Serre, K.; Mohr, E.; Toellner, Kai-M.; Cunningham, A.F.; Bird, R.A.; Khan, M.; MacLennan, Ian C. M.. "Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells". European Journal of Immunology 39 6 (2009): 1573-1586. http://dx.doi.org/10.1002/eji.200838922.
    Published • 10.1002/eji.200838922
  34. Serre, K.; Mohr, E.; Toellner, K-M.; Cunningham, A.F.; Granjeaud, S.; Bird, R.A.; MacLennan, I.C.M.. "Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella". Molecular Immunology 45 13 (2008): 3558-3566. http://dx.doi.org/10.1016/j.molimm.2008.05.010.
    Published • 10.1016/j.molimm.2008.05.010
  35. Cunningham, A.F.; Gaspal, F.; Serre, K.; Mohr, E.; Henderson, I.R.; Scott-Tucker, A.; Kenny, S.M.; et al. "Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection". Journal of Immunology 178 10 (2007): 6200-6207. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248217030&partnerID=MN8TOARS.
    Published • 10.4049/jimmunol.178.10.6200
  36. Sanjiv, L.; Serre, K.; Cunningham, A.F.; Khan, M.; Acha-Orbea, H.; MacLennan, I.C.M.; Toellner, K-M.. "Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells". European Journal of Immunology 37 6 (2007): 1476-1484. http://dx.doi.org/10.1002/eji.200636573.
    Published • 10.1002/eji.200636573
  37. Serre, K.; Giraudo, L.; Siret, C.; Leserman, L.; Machy, P.. "CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cellsin vivo". European Journal of Immunology 36 6 (2006): 1386-1397. http://dx.doi.org/10.1002/eji.200526193.
    Published • 10.1002/eji.200526193
  38. Cunningham, Adam F.; Khan, Mahmood; Ball, Jennifer; Toellner, Kai-Michael; Serre, Karine; Mohr, Elodie; MacLennan, Ian?C.?M.. "Responses to the soluble flagellar protein FliC are Th2, while those to FliC onSalmonella are Th1". European Journal of Immunology 34 11 (2004): 2986-2995. http://dx.doi.org/10.1002/eji.200425403.
    Published • 10.1002/eji.200425403
  39. Cunningham, A.F.; Serre, K.; Mohr, E.; Khan, M.; Toellner, K-M.. "Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction". Immunology 113 2 (2004): 187-193. http://dx.doi.org/10.1111/j.1365-2567.2004.01951.x.
    Published • 10.1111/j.1365-2567.2004.01951.x
  40. Cunningham, A.F.; Serre, K.; Toellner, K-M.; Khan, M.; Alexander, J.; Brombacher, F.; MacLennan, I.C.M.. "Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells". European Journal of Immunology 34 3 (2004): 686-694. http://dx.doi.org/10.1002/eji.200324510.
    Published • 10.1002/eji.200324510
  41. MacLennan, I.C.M.; Toellner, K-M.; Cunningham, A.F.; Serre, K.; Sze, Daniel M.-Y.; Zuniga, E.; Cook, M.C.; Vinuesa, C.G.. "Extrafollicular antibody responses". Immunological Reviews 194 1 (2003): 8-18. http://dx.doi.org/10.1034/j.1600-065X.2003.00058.x.
    Published • 10.1034/j.1600-065x.2003.00058.x
  42. Serre, K.; Giraudo, L.; Henri, S.; Machy, P.; Leserman, L.. "Dendritic cells capture and efficiently present antigen encapsulated in liposomes to T cells in vivo". Journal of Liposome Research 13 1 (2003): 21-23. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037243667&partnerID=MN8TOARS.
    Published • 10.1081/LPR-120017487
  43. Serre, K.; Giraudo, L.; Leserman, L.; Machy, P.. "Liposomes targeted to Fc receptors for antigen presentation by dendritic cells in vitro and in vivo". Methods in Enzymology 373 (2003): 100-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342269087&partnerID=MN8TOARS.
    Published • 10.1016/S0076-6879(03)73007-9
  44. Fichtner, I.; Reszka, R.; Arndt, D.; Zeisig, R.; Gabizon, Alberto; Glück, Reinhard; Koning, G. A.; et al. "Speaker Abstracts". Journal of Liposome Research 13 1 (2003): 97-110. http://dx.doi.org/10.1081/LPR-120017491.
    10.1081/lpr-120017491
  45. Bungener, L.; Serre, K.; Bijl, L.; Leserman, L.; Wilschut, J.; Daemen, T.; Machy, P.. "Virosome-mediated delivery of protein antigens to dendritic cells". Vaccine 20 17-18 (2002): 2287-2295. http://dx.doi.org/10.1016/S0264-410X(02)00103-2.
    Published • 10.1016/s0264-410x(02)00103-2
  46. Machy, P.; Serre, K.; Baillet, M.; Leserman, L.. "Induction of MHC class I presentation of exogenous antigen by dendritic cells is controlled by CD4+ T cells engaging class II molecules in cholesterol-rich domains1". Journal of Immunology 168 3 (2002): 1172-1180. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036467526&partnerID=MN8TOARS.
    Published • 10.4049/jimmunol.168.3.1172
  47. Machy, P.; Serre, K.; Leserman, L.. "Class I-restricted presentation of exogenous antigen acquired by Fcg receptor-mediated endocytosis is regulated in dendritic cells". European Journal of Immunology 30 3 (2000): 848-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033998027&partnerID=MN8TOARS.
    Published • 10.1002/1521-4141(200003)30:3<848::AID-IMMU848>3.0.CO;2-Q
  48. Machy, Patrick; Serre, Karine; Leserman, Lee. "Class I-restricted presentation of exogenous antigen acquired by Fc¿ receptor-mediated endocytosis is regulated in dendritic cells". European Journal of Immunology 30 3 (2000): 848-857. http://dx.doi.org/10.1002/1521-4141(200003)30:3<848::AID-IMMU848>3.3.CO;2-H.
    10.1002/1521-4141(200003)30:3<848::aid-immu848>3.3.co;2-h
  49. Zimmermann, V.S.; Rovere, P.; Trucy, J.; Serre, K.; Machy, P.; Forquet, F.; Leserman, L.; Davoust, J.. "Engagement of B cell receptor regulates the invariant chain-dependent MHC class II presentation pathway". Journal of Immunology 162 5 (1999): 2495-2502. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033105492&partnerID=MN8TOARS.
  50. Serre, K.; Machy, P.; Grivel, J.-C.; Jolly, G.; Brun, N.; Barbet, J.; Leserman, L.. "Efficient presentation of multivalent antigens targeted to various cell surface molecules of dendritic cells and surface Ig of antigen-specific B cells". Journal of Immunology 161 11 (1998): 6059-6067. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032400942&partnerID=MN8TOARS.
    Published

Other

Other output
  1. Immunopathology and parasite sequestration cause severe cerebral trypanosomiasis in animals. 2021. Sara Silva Pereira; Mariana De Niz; Karine Serre; Marie Ouarné; Claudio A Franco; Luisa M Figueiredo. https://doi.org/10.21203/rs.3.rs-1050698/v1.
    10.21203/rs.3.rs-1050698/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/03 Cancer Immunotherapy – Lymphocytes to fight Cancer, mainly CAR T-Cells and gd T-Cells VIII AEICBAS Biomedical Congress
(Porto, Portugal)
2020/02/26 Bringing new allies to cancer therapy: i) How to instruct myeloid cells to fight cancer?, ii) Methionine increases the efficacy of anti-PD-1. Invited Talk
Universidade de Aveiro (Aveiro, Portugal)
2019/06 Immunotherapy in cancer The European Human Genetics Conference (ESGH)
(Gothenburg, Sweden)
2019/03 Why so much hope about immunotherapy? XI Jornadas de Genética e Biotecnologia I Jornadas Ibéricas de Genética y Biotecnología
Universidade de Trás-os-Montes e Alto Douro (UTAD) (Vila Real, Portugal)
2018/11 Different signalling pathways govern the emergence of macrophages and neutrophils with anti-tumour functions Regulatory myeloid cells (MRC) in health and Disease – COST- Action – Annual Meeting
(Essen, Germany)
2018/06 Different signalling pathways govern the emergence of macrophages and neutrophils with anti-tumour functions 8th International conference on tumour microenvironment: progression, therapy and prevention
(Lisboa, Portugal)
2018/05 Why so much hope about immunotherapy? 2nd Symposium of the MSc in Oncology
(Porto, Portugal)
2018/04 Different signalling pathways govern the emergence of macrophages and neutrophils with anti-tumour functions 25th Porto CANCER meeting: Cancer Wars the immune force awakens
(Porto, Portugal)
2017/11 Host: Harnessing the power of the immune system is key CUF International meeting on cancer innovation
(Porto (10th Nov), Liboa (11th Nov) , Portugal)
2017/06 Anti-tumour macrophages: myth or reality? Symposium on Immunomodulation in Cancer & Regeneration
(Porto, Portugal)
2017/03 Role of neutrophils in IL-17-dependent tumours: Tumour-associated neutrophils inhibit pro-tumour IL-17-producing gd T cells Regulatory myeloid cells (MRC) in health and Disease – COST- Action – 4th ECI Workshop
(Brno, Czech Republic)
2016/04 Tumour-associated neutrophils inhibit pro-tumour IL17-producing gamma-delta T cells 2nd ASPIC international congress
(Porto, Portugal)
2015/06 In vivo inhibition of tumour-associated IL-17-producing gd T cells by neutrophils Seventh International ¿d T-Cell Conference
(London, United Kingdom)
2013/11 In vivo molecular signatures of stable versus plastic gamma delta T cell subsets Congrès Annuel de la Société Française d’Immunologie (SFI)
(Paris, France)
2013/11 In vivo molecular signatures of stable versus plastic gamma delta T cell subsets SPI Annual Meeting
(Coimbra, Portugal)
2013/10 In vivo molecular signatures of stable versus plastic gamma delta T cell subsets that promote inflammation 1st IMM Post-doc Symposium
(Lisboa, Portugal)
2013/06 Regulation of IL-17 and IFN-g expression in gd T cells Invited Talk
Centre d'Immunologie de Marseille-Luminy (CIML), Université de la Méditerranée (Marseille, France)
2013/06 Regulation of IL-17 and IFN-g expression in gd T cells Invited Talk
Institut de Pharmacologie Moléculaire et Cellulaire (IPMC), Université de Nice-Sophia Antipolis (Nice, France)
2013/05 Regulation of IL-17 and IFN-g expression in gd T cells 16e Colloque Cytokines et Chimiokines du Croisic (CCCC16)
(Croisic, France)
2009/06 GATA-3, c-Maf, Helios mRNA expression related to Th2-cytokine control in T cells responding in vivo 16th Germinal Centre Conference
(Franckfurt, Germany)
2007 Early emergence of diversity in T cells making a primary Th2 response 13th International Congress of Immunology
(Rio de Janeiro, Brazil)
2001/05 In vitro and ex vivo characterization of dendritic cells as the major cell type responsible for liposome capture in lymph nodes and for presentation of liposome-encapsulated antigen to CD4+ and CD8+ T cells European Network of Immunology Institutes, ENII Conference
(Iles des Embiez, France)
2000/11 Présentation antigénique dans le contexte des molécules du CMH de classe II et de classe I par les cellules dendritiques in vitro et in vivo Club Francophone des Cellules Dendritiques (CFDC)
(Paris, France)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - Current Combined immUNotherapeutIC approach for targeting bone marrow microenvironment in Multiple Myeloma
Co-supervisor of Ana Raquel Vicente Lopes
Programa Champalimaud de Investigação Portugal (PhD)
Fundação Champalimaud, Portugal
2021 - Current Single-cell transcriptomics in unravelling the complexity of the breast tumour microenvironment
Co-supervisor of Ana Marta Fernandes Bica
CAML PhD program (PhD)
Instituto de Medicina Molecular, Portugal
2020 - Current Monocytes/macrophages as allies against cancer: how to instruct them to protect primary tumour growth and prevent metastasis?
Supervisor of Carolina Jardim
 PhD - FCT fellowship (PhD)
Instituto de Medicina Molecular, Portugal
2019 - Current Programming macrophages for effective immunotherapy
Supervisor of Afonso Teixeira da Mota
M.Sc. student FMUL 4th Oncobiology edition (Master)
Instituto de Medicina Molecular, Portugal
2017 - Current Targeted delivery of carbon monoxide using artificial metalloantibodies for cancer immunotherapy
Co-supervisor of Carlos Diogo Labão Sousa de Almeida
 PhD - LisbonBiomed (PhD)
Instituto de Medicina Molecular, Portugal
2019 - 2021 Manipulation of the myeloid compartiment to improve cancer immunotherapy
Supervisor of Mariana Reis Sobreiro
Post-Doc
Instituto de Medicina Molecular, Portugal
2016 - 2020 Regulation of T cell fitness and function in tumour responses
Co-supervisor of Sofia Mensurado Santos
 PhD - LisbonBiomed (PhD)
Instituto de Medicina Molecular, Portugal
2019 - 2019 Lymphoid and myeloid cell responses and metabolic fitness in the tumour microenvironment
Co-supervisor of Tommaso Scolaro
 ERASMUS (Master)
Instituto de Medicina Molecular, Portugal
2018 - 2018 Characterisation of anti-tumour macrophages in vitro and in vivo
Supervisor of Henning Boekoff
 ERASMUS (Master)
Instituto de Medicina Molecular, Portugal
2017 - 2018 Methionine supplementation improves the efficacy of breast cancer immunotherapy
Supervisor of Tiago Roberto Gomes Pestana
 M.Sc. student Faculdade de Ciências e Tecnologia (Master)
Universidade Nova de Lisboa, Portugal
2017 - 2018 Programming anti tumour myeloid cells for effective immunotherapy
Supervisor of Raquel Lopes
 M.Sc. student FMUL 3rd Oncobiology edition (Master)
Instituto de Medicina Molecular, Portugal
2016 - 2017 Characterization of anti tumour myeloid cells in a mouse model of transplantable mammary tumour
Supervisor of Miguel Alexandre Ferreira Pinto
M.Sc. Instituto de Ciências Biomédicas Abel Salazar (Master)
Universidade do Porto, Portugal
2014 - 2015 Crosstalk between protective lymphoid and immunosuppressive myeloid tumour infiltrating cells
Supervisor of Sofia Mensurado Santos
 M.Sc. FCUL 1st Biochemistry (Master)
Instituto de Medicina Molecular, Portugal
2013 - 2015 Regulation of gd T cell effector functions
Supervisor of Joana Barros-Martins
M.Sc. FCUL 1st Biochemistry (Master)
Instituto de Medicina Molecular, Portugal
2013 - 2013 The role of the transcription factor BATF in gd T cell differentiation and functionality
Co-supervisor of Michael Hamm
 Master Cellular and molecular biology at University Pierre et Marie Curie (UPMC) (Master)
Instituto de Medicina Molecular, Portugal
2012 - 2013 Effector gd T cells: Cytokine expression and regulation
Co-supervisor of Ingrid Brok
Master Cell Biology and Immunology Group at the Wageningen University, The Netherlands (Master)
Instituto de Medicina Molecular, Portugal
2006 - 2010 Description of the microenvironment supporting plasmablast maturation and survival in lymph nodes
Co-supervisor of Elodie Mohr
Post-Doc
Birmingham MRC Centre for Immune Regulation, United Kingdom
2007 - 2007 Role of IL-4 in inducing the follicular T cell differentiation in vivo
Co-supervisor of Julie Losbtein
 Master Ecole Supérieure de Biotechnologie de Strasbourg, France (Master)
Birmingham MRC Centre for Immune Regulation, United Kingdom

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/10/03 - 2023/10/04 Two Days Training School: "Brainstorming on analysis of multiplexed images" of the COST action CA20117 - Mye-InfoBank (2023/10/03 - 2023/10/04)
Workshop (Co-organisor)
 Katholieke Universiteit Leuven Bibliotheken, Belgium
2018/01/01 - 2018/06/14 8th International conference on tumour microenvironment: progression, therapy and prevention. Lisboa (Portugal). (2018)
Conference (Member of the Organising Committee)
2014/01/01 - 2014/10/15 40th Annual Meeting of the Portuguese Society for Immunology (SPI). IMM - Lisboa (Portugal). (2014/10/13 - 2014/10/15)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2013/10/30 - 2013/10/30 One-day workshop on “grant writing”. Dr. Judith Swan (Princeton University – USA). IMM - Lisboa (Portugal). (2013/10/30 - 2013/10/30)
Workshop (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/06/06 - 2018/06/09 Different signalling pathways govern the emergence of macrophages and neutrophils with anti-tumour functions. Poster Presentation
Conference
 TOLL 2018- Editing innate immunity
2018/04/16 - 2018/04/18 Different signalling pathways govern the emergence of macrophages and neutrophils with anti-tumour functions. Poster Presentation
Conference
 Regulatory myeloid cells (MRC) in health and Disease – COST- Action – 5th ECI Workshop
2017/09/03 - 2017/09/04 A macrophage-centric view of cancer - Anti-tumour macrophages: myth or reality? Poster Presentation
Conference
 CRUK Beatson Institute: Understanding immunology Workshop
2017/06/14 - 2017/06/16 Anti-tumour macrophages: myth or reality? Poster Presentation
Meeting
 SPI Annual Meeting
2016/04/10 - 2016/04/14 Tumour-associated neutrophils inhibit pro-tumour IL17-producing gd T cells. Poster Presentation
Conference
 Keystone symposia: Myeloid Cells (D3)
2015/09/14 - 2015/09/16 Sometimes myeloid suppressive cells get it wrong: tumour-associated neutrophils inhibit pro-tumour IL-17-producing gd T cells. Poster Presentation
Conference
 Regulatory myeloid cells (MRC) in health and Disease – COST- Action – Conference and Workshop.
2014/05/31 - 2014/06/02 Unconventional functions of “master” transcription factors in gd T cells. Poster Presentation
Conference
 Sixth International gd T-Cell Conference - Chicago
2012/11/26 - 2012/11/28 Transcriptional and epigenetic signatures of IFN-g+ or IL-17+ gd T cell subsets. Poster Presentation
Meeting
 SPI Annual Meeting
2012/09/05 - 2012/09/08 Transcriptional and epigenetic signatures of pro-inflammatory gd T cell subsets. Poster Presentation
Congress
 3rd European Congress of Immunology
2012/05/31 - 2012/06/02 Transcriptional and epigenetic mechanisms of differentiation of pro-inflammatory gd T cell subsets. Poster Presentation.
Conference
 Fifth International gd T-Cell Conference
2011/11/29 - 2011/11/30 Selective effects of NF-kB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines. Poster Presentation
Meeting
 SPI Annual Meeting
2010/12/06 - 2010/12/10 Selective effects of NF-kB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines. Poster Presentation
Meeting
 BSI Annual Meeting
2009 - 2009 Expression of GATA-3, c-Maf and Helios transcription factor mRNA by CD4 T cells responding to Th2 antigen in vivo. Poster Presentation
Congress
 European Congress of Immunology
1997/11/26 - 1997/11/28 The antigen presenting functions of surface immunoglobulin on B cells and Fc receptors on dendritic cells are analogous. Poster presentation.
Congress
 Congrès Annuel de la Société Française d’Immunologie (SFI)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/06/17 Intercellular relationships in the tumor microenvironment: implications for cancer pathophysiology
(Thesis) Main arguer
 Ana Isabel Ferreira de Oliveira (PhD)
Universidade do Minho Escola de Medicina, Portugal
2019/04/01 Thymic activities in the establishment of tumor immune tolerance
(Thesis) Arguer
 José Guilherme Pereira de Almeida Santos (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/10/12 Plasmodium berghei liver infection inhibition by host immune response to Trypanosoma brucei
(Thesis) Main arguer
 Rafael Alexandre Carvalho Luís (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2020 - Current Associação Portuguesa de Investigação em Cancro (ASPIC) Member
2012 - Current Sociedade Portuguesa de Imunologia (SPI) Member
2005 - Current British Society of Immunology (BSI) Member
2000 - Current Société Française d'Immunologie (SFI) Member

Committee member

Activity description
Role 		Institution / Organization
2023/02 - Current Portuguese Immuno-Oncology SPO-SPI Group
Member
2018/09/01 - 2021 Board of Direction of the Sociedade Portuguesa de Imunologia (SPI).
Other

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022/12 - Current Licenciatura Cienca da Nutricao - Innate Immunity – Pattern Recognition Receptors Innate Immunity – Pattern Recognition Receptors (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2022/12 - Current Licenciatura Cienca da Nutricao - Macrophages and Dendritic cells Macrophages and Dendritic cells (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2022/12 - Current Licenciatura Cienca da Nutricao - Inflammation Inflammation (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2022/10 - Current Mestrado Integrado em Medicina - 2 year - Practicals - Innate Immunity TRONCO COMUM II. A) MICROBIOLOGIA, IMUNIDADE E INFECCIOLOGIA – 2º ANO (Mestrado integrado) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2019/12/14 - Current Licenciatura Cienca da Nutricao - Tumour Immunology Tumour Immunology (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2019/11/12 - Current Licenciatura Cienca da Nutricao - Caloric restriction and immune response Caloric restriction and immune response (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2019/01/05 - Current Licenciatura Cienca da Nutricao - Cancer Immunotherapy Cancer Immunotherapy (Licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2021/02/02 - 2021/02/05 UC Oncoimunologia - MSc/CE Oncobiologia Leukocyte subsets in the tumour microenvironment - Tumour immunity (Mestrado) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2020/12/12 - 2020/12/14 Universidade Lusófona Lymphoid and Myeloid cell in Tumours. Harnessing the power of the immune system: Immunotherapy (Ensino básico 3º ciclo) Universidade Lusófona, Portugal
2020/10/20 - 2020/10/20 Mestrado integrado em ciências farmacêuticas -“Alvos Terapêuticos e Biomarcadores” and “Oncobiologia e Medicina de Precisão” Immunotherapeutic Strategies Against Cancer”. (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/28 - 2020/01/28 Lisbon BioMed PhD Program Tumour immunity: focus on myeloid cells (Doutoramento) Instituto de Medicina Molecular, Portugal
2019/12/09 - 2019/12/09 MCDIE Mestrado de doenças infecciosas Diversification of T helper cell functions (Mestrado) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2019/11/26 - 2019/11/26 Mestrado integrado em ciências farmacêuticas Modulo: Alvos Terapêuticos e Biomarcadore Harnessing the immune system for immunotherapy (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/04/17 - 2019/04/17 4º ano do Mestrado Integrado em Ciências Farmacêuticas Why so much hope about immunotherapy? Harnessing the power of the immune system: Immunotherapy (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/04/08 - 2019/04/08 3rd year Medical students Oncobiology: On the Cancer & the Host (Especialização pós-licenciatura) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2019/02/05 - 2019/02/05 Mestrado em Oncobiologia – Módulo de Oncoimunologia Leukocyte subsets in the tumour microenvironment - Tumour immunity (Mestrado) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2018/11/11 - 2018/11/11 Life health and sciences (2 years) Tumour Immunology (Licenciatura) Centro Académico de Medicina de Lisboa (CAML), Portugal
2018/06/21 - 2018/06/21 GABBA PhD program of the University of Porto Immune subsets in the tumour microenvironment and their role during (immuno)therapies (Doutoramento) Universidade do Porto, Portugal
2018/05/11 - 2018/05/11 2nd Symposium of the MSc in Oncology, Porto Why so much hope about immunotherapy? (Licenciatura) Universidade do Porto, Portugal
2018/02/05 - 2018/02/05 LisbonBioMed PhD student Programme Immunology course: “Diversification of T helper cell functions”. (Doutoramento) iMM-JLA / LisbonBioMed PhD student Programme, Portugal
2018/01/16 - 2018/01/16 LisbonBioMed PhD student Programme Immunology course: “Tumour immunology and Cancer Immunotherapy”. (Doutoramento) iMM-JLA / LisbonBioMed PhD student Programme, Portugal
2017/11/06 - 2017/11/17 MCDIE Mestrado de doenças infecciosas Diversification of T helper cell responses (Mestrado) A Faculdade de Medicina da Universidade de Lisboa (FMUL), Portugal
2017/02/02 - 2017/02/02 LisbonBioMed PhD student Programme Diversification of T helper cell responses (Doutoramento) iMM-JLA / LisbonBioMed PhD student Programme, Portugal
2017/01/11 - 2017/01/11 Mestrado em Oncobiologia – Módulo de Oncoimunologia Leukocyte subsets in the tumor microenvironment (Mestrado) Centro Académico de Medicina de Lisboa (CAML), Portugal
2016/02/01 - 2016/02/01 LisbonBioMed PhD student Programme Effector T cells (Doutoramento) iMM-JLA / LisbonBioMed PhD student Programme, Portugal
2015/02/02 - 2015/02/02 LisbonBioMed master student Programme Innate gd T cell functional differentiation (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2014/02/04 - 2014/02/04 LisbonBioMed PhD student Programme Molecular mechanisms of T cell differentiation (Doutoramento) Instituto de Medicina Molecular, Portugal
2013/06/03 - 2013/06/05 Nanocourse CAML PhD Programme Challenges in Immunology: Challenges in T cell differentiation (Doctor) Centro Académico de Medicina de Lisboa (CAML), Portugal
2009/09 - 2009/12 Small Group Teaching for Medical students (2nd year MBChB) (15 tutorials) 2nd year MBChB (Magister (2nd cycle)) University of Birmingham College of Medical and Dental Sciences, United Kingdom
1999 - 2000 Teaching Pratical Lab courses: ELISA test and Immuno-electrophoresis. Bachelor degree in Immunology Aix-Marseille Université, France

Mentoring / Tutoring

Topic Student name
2019/01/01 - Current Targeting the CCL2-CCR2 axis in metastatic medulloblastoma. Carlos Manuel Tavares Da Custodia (PhD thesis committee)
2018/01/01 - Current Mechanisms of T follicular regulatory cell differentiation. Filipa Ramos de Moura Ribeiro (PhD thesis committee)
2016/01/01 - Current Transcriptomics of the follicular regulatory T cells analysed at the single cell levels. Saumya Dileep Kumar (PhD thesis committee)
2017 - 2020/07 Translating Breast Cancer Immune Features Into Biomarkers and Therapies Diana Isabel Pereira Saraiva (PhD thesis committee)
2016/01/01 - 2018/12/30 Follicular regulatory T cells in human diseases. Válter Bruno Ribeiro Fonseca (PhD thesis committee)
2013/01/01 - 2015/12/30 Follicular regulatory T cells. Ana Raquel Maceira (PhD thesis committee)

Other jury / evaluation

Activity description Institution / Organization
2018 - 2019 Reviewer of grant applications for "Prémios Pfizer " Pfizer Portugal, Portugal
2018 - 2018 Reviewer of grant applications for the caritative association "Breast Cancer Now" Breast Cancer Now, United Kingdom
Distinctions

Award

2023 Gilead Génese Program award (10,000€).
Gilead Sciences Lda, Portugal
2018 Prémio de Investigação FAZCiência 2018 (3rd place).
Fundação AstraZeneca e a Sociedade Portuguesa de Oncologia, Portugal
2018 First prize of the 2nd Edition of the Prémio Janssen Inovação (€30,000).
Janssen-Cilag Farmacêutica Lda, Portugal
2017 Best Oral Presentation - Symposium on Immunomodulation in Cancer & Regeneration I3S/IPO-Porto, PORTUGAL
2014 Best Poster Award - SPI Annual Meeting (€500)
Sociedade Portuguesa de Imunologia, Portugal
2013 Travel Grant Award (500€)
Sociedade Portuguesa de Imunologia, Portugal
2012 Travel Grant Award (€500)
Sociedade Portuguesa de Imunologia, Portugal