???global.info.a_carregar???
Maria João Sebastião holds a PhD in Bioengineering, MIT-Portugal Program, from ITQB NOVA University of Lisbon, a Master in Biotechnology from Instituto Superior Técnico (University of Lisbon) and a BSc in Biology from the Faculty of Sciences (University of Lisbon). Her PhD research is focused in the characterization of human cardiac cell populations in contexts of homeostasis and acute myocardial ischemia, including human cardiac progenitor cells and human cardiac fibroblasts, as well as to develop relevant ischemia/reperfusion in vitro human cell models exploring omic tools. Her current work is focused on antibody production using mammalian cell suspension cultures, with a focus on process understanding through OMIC technologies.
Read full resume ↓
Identification

Personal identification

Full name
Maria João Carvalho Sebastião

Citation names

  • Sebastião, Maria

Author identifiers

Ciência ID
1E12-C5BF-F57A
ORCID iD
0000-0001-7572-7106

Knowledge fields

  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Spanish; Castilian Elementary (A2) Elementary (A2) Beginner (A1) Intermediate (B1) Beginner (A1)
Portuguese (Mother tongue)
Education
Degree Classification
2014/01/01 - 2018/09/19
Concluded
 PhD in Bioengineering Systems (Doutoramento)
Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Towards novel stem cell and protein-based therapies for myocardium regeneration. " (THESIS/DISSERTATION)
2014/01/01 - 2014/12/31
Concluded
 MIT-Portugal PhD programme (Curso de doutoramento (conclusão de unidades curriculares))
Major in Bioengineering systems
Universidade Nova de Lisboa, Portugal
 18
2013
Concluded
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Expansion of human Neural Stem Cells in microcarrier-based spinner flask culture systems" (THESIS/DISSERTATION)
 18
2011
Concluded
 Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 16
2011
Concluded
 Curso de Empreendedorismo – Interdisciplinary Entrepreneurship Program (Outros)
Universidade de Lisboa, Portugal
"n/a" (THESIS/DISSERTATION)
 16
2011
Concluded
 Período de estudo ERASMUS durante a licenciatura (Bacharelato)
Universität zu Köln Fachgruppe Biologie, Germany
"n/a" (THESIS/DISSERTATION)
 n/a
Affiliation

Others

Category
Host institution 		Employer
2017/05 - 2017/07 PhD internship: Immunomodulatory properties of human cardiac stem cells TiGenix, Spain
2014/05 - 2014/05 MIT Portugal PhD Lab Rotation: MEsenchymal Stem cell therapy in neurodegenerative mouse model Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2013 MSC Thesis internship:Expansion of human Neural Stem Cells in microcarrier-based spinner flask culture systems. Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2011/07/04 - 2011/07/24 Assistente de laboratório. Realização de estágio em citogenética clássica e molecular de tumores sólidos do sistema nervoso central humano. Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
2009/05/04 - 2009/07/06 Assistente de laboratório. Participação em projecto sobre caracterização molecular de plantas aromáticas endémicas de Portugal. Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2008/09/08 - 2008/09/22 Assistente de laboratório. Participação em projecto sobre o efeito da vitamina D na proliferação de tumores cancerígenos em cancro mamário. Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Outputs

Publications

Book chapter
  1. Sebastião, Maria. "3D Strategies for expansion of human cardiac stem cells". In Bioreactors for Stem Cell Expansion and Differentiation. CRC Press, 2018.
Journal article
  1. Maria João Sebastião; Michael Hoffman; Escandell JM; Fatemeh Tousi; Jin Zhang; Bruno Figueroa; Christine DeMaria; Patrícia Gomes-Alves. "Identification of Mispairing Omic Signatures in Chinese Hamster Ovary (CHO) Cells Producing a Tri-Specific Antibody". Biomedicines (2023): http://dx.doi.org/10.3390/biomedicines11112890.
    10.3390/biomedicines11112890
  2. Maria J. Sebastião; Henrique Vazão de Almeida; Margarida Serra; Nazha Hamdani; Francisca Saraiva; André P. Lourenço; António S. Barros; et al. "Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction". Biomedicines 10 11 (2022): 2943-2943. http://dx.doi.org/10.3390/biomedicines10112943.
    10.3390/biomedicines10112943
  3. Maria J Sebastião; Margarida Serra; Patrícia Gomes-Alves; Paula M Alves. "Stem cells characterization: OMICS reinforcing analytics". Current Opinion in Biotechnology 71 (2021): 175-181. http://dx.doi.org/10.1016/j.copbio.2021.07.021.
    10.1016/j.copbio.2021.07.021
  4. Maria J. Sebastião; Lara Marcos-Silva; Patrícia Gomes-Alves; Paula M. Alves. "Proteomic and Glyco(proteo)mic tools in the profiling of cardiac progenitors and pluripotent stem cell derived cardiomyocytes: Accelerating translation into therapy". Biotechnology Advances 49 (2021): 107755-107755. http://dx.doi.org/10.1016/j.biotechadv.2021.107755.
    10.1016/j.biotechadv.2021.107755
  5. Sebastião, Maria J.; Gomes-Alves, Patrícia; Reis, Ivo; Sanchez, Belén; Palacios, Itziar; Serra, Margarida; Alves, Paula M.. "Bioreactor-based 3D human myocardial ischemia/reperfusion in vitro model: a novel tool to unveil key paracrine factors upon acute myocardial infarction". Translational Research 215 (2020): 57-74. http://dx.doi.org/10.1016/j.trsl.2019.09.001.
    10.1016/j.trsl.2019.09.001
  6. José Luis Torán; Juan Antonio López; Patricia Gomes-Alves; Susana Aguilar; Carlos Torroja; Marco Trevisan-Herraz; Isabel Moscoso; et al. "Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-39571-x.
    10.1038/s41598-019-39571-x
  7. Sebastião, Maria J.; Serra, Margarida; Pereira, Rute; Palacios, Itziar; Gomes-Alves, Patrícia; Alves, Paula M.. "Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model". Stem Cell Research & Therapy 10 1 (2019): http://dx.doi.org/10.1186/s13287-019-1174-4.
    10.1186/s13287-019-1174-4
  8. Sebastião, Maria J; Menta, Ramón; Serra, Margarida; Palacios, Itziar; Alves, Paula M; Sanchez, Belén; DelaRosa, Olga; et al. "Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity". Stem Cell Research & Therapy 9 1 (2018): http://dx.doi.org/10.1186/s13287-018-1010-2.
    10.1186/s13287-018-1010-2
  9. Sebastião, Maria João; Pereira, Rute; Serra, Margarida; Gomes-Alves, Patrícia; Alves, Paula Marques. "Unveiling Human Cardiac Fibroblast Membrane Proteome". PROTEOMICS 18 13 (2018): 1700446. http://dx.doi.org/10.1002/pmic.201700446.
    10.1002/pmic.201700446
  10. Cláudia Correia; Alexey Koshkin; Patrícia Duarte; Dongjian Hu; Madalena Carido; Maria J. Sebastião; Patrícia Gomes-Alves; et al. "3D aggregate culture improves metabolic maturation of human pluripotent stem cell derived cardiomyocytes". Biotechnology and Bioengineering (2018): https://doi.org/10.1002/bit.26504.
    10.1002/bit.26504