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Angelo M Figueiredo is an experienced Research Scientist devoted most of his career to application and development of nuclear magnetic resonance (NMR) spectroscopy as a major biophysical technique for structural & dynamical studies of biomolecules. He has been working as NMR facility manager at the NMR centre of Institute of Structural and Molecular Biology (ISMB) at University College London, UK. Here, has been involved and collaborating in multiple scientific projects, providing not only technical expertise but also leadership abilities, coordinating input from academic and postdoctoral staff, and students. As a problem solver with a passion for theoretical and technical detail he develops creative and effective solutions for the extend range of emerging problems, not only tools (i.e. programming skills - Python, Matlab and C++) but also new concepts and ideas. The range of projects and ideas involved span from physical-chemistry to life sciences is referee for specialised Journals from Royal Society of Chemistry and American Chemical Society. During his Phd and Postdoc studies have gained a broad range of scientific skills including ITC, DSC and EPR in order to explore biomolecular interactions and protein stability. Strong interpersonal skills including mentoring, coaching, collaborating and team building (Supervision of 1 PhD Student, 2 Master Students and 4 Diploma Students; Lecturer/Tutor in seminars/courses across Europe) Able to develop and organise project ideas in order to delivery and present research results (publications, conferences, meetings), as well as management (funding applications, grants, awards) and communication skills
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Identification

Personal identification

Full name
Angelo Miguel Mendes Pinto de Figueiredo

Citation names

  • Figueiredo, Angelo M

Author identifiers

Ciência ID
1E19-3AC2-88C9
ORCID iD
0000-0001-7039-5341

Email addresses

  • amfigueiredo@qui.uc.pt (Professional)

Addresses

  • NMR Lab Chemistry Department - University Coimbra, Rua Larga 2, 3004-535, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English (Mother tongue)
Education
Degree Classification
2011/07/19
Concluded
 Biomolecular NMR (Doctor of Philosophy)
Major in Protein Folding, NMR Spectroscopy
University of East Anglia School of Chemistry, United Kingdom

University of Leeds School of Molecular and Cellular Biology, United Kingdom
"Navigation of the Folding Landscape of Colicin Immunity Proteins" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2024/06/01 - Current Auxiliary Researcher (Research) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Química de Coimbra, Portugal

Positions / Appointments

Category
Host institution 		Employer
2015/09/01 - 2024/06/30 Manager of Laboratory, Institute, Museum, Centre or Observatory University College London Division of Biosciences, United Kingdom
Institute of Structural and Molecular Biology Research Department of Structural and Molecular Biology, United Kingdom
Projects

Grant

Designation Funders
2013/07 - 2016/06 NMR Net - National Facility for Nuclear Magnetic Resonance: from Molecular Structure and Dynamics to Protein Function, Cell Physiology, and Metabolomics
Provided by PTCRIS: 127013
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. Silva, Micael S.; Viegas, Aldino; Philip O'Toole; Figueiredo, Angelo M; Cabrita, Eurico J.. "Choline glutamate modulates protein folding and stability: an NMR view". Paper presented in 2020 CCPN Conference online, 2020.
Journal article
  1. Julian O. Streit; Ivana V. Bukvin; Sammy H. S. Chan; Shahzad Bashir; Lauren F. Woodburn; Tomasz Wlodarski; Angelo Miguel Figueiredo; et al. "The ribosome lowers the entropic penalty of protein folding". Nature (2024): https://doi.org/10.1038/s41586-024-07784-4.
    10.1038/s41586-024-07784-4
  2. Tabor, Alethea; Darling, William; Wieske, Lianne; Cook, Declan; Aliev, Abil; Caron, Laurent; Humphrys, Emily J; et al. Corresponding author: Tabor, Alethea. "The Influence of Disulfide, Thioacetal and Lanthionine-Bridges on the Conformation of a Macrocyclic Peptide". Chemistry – A European Journal (2024): http://dx.doi.org/10.1002/chem.202401654.
    Open access • In press • 10.1002/chem.202401654
  3. Pettitt, Alice J.; Shukla, Vaibhav K.; Newton, Lydia S.; Figueiredo, Angelo M.; McCarthy, Stephen; Tabor, Alethea B.; Heller, Gabriella T.; Lorenz, Chris D.; Hansen, D. Flemming. "Atomistic ensemble resolution of an intrinsically disordered peptide which undergoes proline cis/trans isomerisation". Biophysical Journal 123 3 (2024): 25a. http://dx.doi.org/10.1016/j.bpj.2023.11.256.
    Published • 10.1016/j.bpj.2023.11.256
  4. Gabriella T. Heller; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; D. Flemming Hansen. "Picosecond Dynamics of a Small Molecule in Its Bound State with an Intrinsically Disordered Protein". Journal of the American Chemical Society (2024): https://doi.org/10.1021/jacs.3c11614.
    10.1021/jacs.3c11614
  5. Giuseppe Nicastro; Giancarlo Abis; Pierre Klein; Sofia Esteban-Serna; Christopher Gallagher; Belen Chaves-Arquero; Yuyang Cai; et al. "Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers". Nucleic Acids Research (2023): https://doi.org/10.1093/nar/gkad534.
    10.1093/nar/gkad534
  6. Rachael Dickman; Serena A. Mitchell; Angelo M. Figueiredo; D. Flemming Hansen; Alethea B. Tabor. "Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B". The Journal of Organic Chemistry (2019): https://doi.org/10.1021/acs.joc.9b01253.
    10.1021/acs.joc.9b01253
  7. Fabian Blombach; Darya Ausiannikava; Angelo Miguel Figueiredo; Zoja Soloviev; Tanya Prentice; Mark Zhang; Nanruoyi Zhou; et al. "Structural and functional adaptation of Haloferax volcanii TFEa/ß". Nucleic Acids Research 46 5 (2018): 2308-2320. https://doi.org/10.1093%2Fnar%2Fgkx1302.
    10.1093/nar/gkx1302
  8. Karola Gerecht; Angelo Miguel Figueiredo; D. Flemming Hansen. "Determining rotational dynamics of the guanidino group of arginine side chains in proteins by carbon-detected NMR". Chemical Communications 53 72 (2017): 10062-10065. https://doi.org/10.1039/C7CC04821A.
    10.1039/C7CC04821A
  9. Figueiredo, Angelo; Veeramuthu, Sivanandam; Millet, Oscar; Cabrita, Eurico. "Breaking the deleterious effect of urea-unfolded state: consequences for the reversibility of inter-mediate species". Protein Science (2015): https://publons.com/wos-op/publon/20527642/.
  10. Silva, Micael; Figueiredo, Angelo Miguel; Cabrita, Eurico J.. "Epitope mapping of imidazolium cations in ionic liquid-protein interactions unveils the balance between hydrophobicity and electrostatics towards protein destabilisation". Physical Chemistry Chemical Physics (2014):
    10.1039/C4CP03534H
  11. Figueiredo, Angelo M. "Conformational dynamics is more important than helical propensity for the folding of the all a-helical protein Im7". Protein Science (2013): http://dx.doi.org/10.1002/pro.2372.
    10.1002/pro.2372
  12. Rajpal, Aman; Dube, Simmi; Carvalho, Filipa; Simoes, Ana Rita; Figueiredo, Angelo; Basu, Ananda; Jones, John; Basu, Rita. "Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes". American Journal of Physiology-Endocrinology and Metabolism 305 4 (2013): E465-E474.
    10.1152/ajpendo.00245.2013
  13. Figueiredo, Angelo Miguel; Sardinha, Joao; Moore, Geoffrey R.; Cabrita, Eurico J.. "Protein destabilisation in ionic liquids: the role of preferential interactions in denaturation". Physical Chemistry Chemical Physics 15 45 (2013): 19632-19643.
    10.1039/C3CP53395F
  14. Figueiredo, Angelo Miguel; Moore, Geoffrey R.; Whittaker, Sara B. -M.. "Understanding how small helical proteins fold: conformational dynamics of Im proteins relevant to their folding landscapes". Biochemical Society Transactions 40 (2012): 424-428.
    10.1042/BST20110739
  15. Knowling, Stuart E.; Figueiredo, Angelo Miguel; Whittaker, Sara B-M.; Moore, Geoffrey R.; Radford, Sheena E.. "Amino Acid Insertion Reveals a Necessary Three-Helical Intermediate in the Folding Pathway of the Colicin E7 Immunity Protein Im7". Journal of Molecular Biology 392 4 (2009): 1074-1086.
    10.1016/j.jmb.2009.07.085
  16. Lopez-Cortes, A; Bursakov, S; Figueiredo, A; Thapper, AE; Todorovic, S; Moura, JJG; Ollivier, B; Moura, I; Fauque, G. "Purification and preliminary characterization of tetraheme cytochrome c(3) and adenylylsulfate reductase from the peptidolytic sulfate-reducing bacterium Desulfovibrio aminophilus DSM 12254". Bioinorganic Chemistry and Applications 3 1-2 (2005): 81-91.
    10.1155/BCA.2005.81
Preprint
  1. Alice J. Pettitt; Vaibhav Kumar Shukla; Angelo Miguel Figueiredo; Lydia S. Newton; Stephen McCarthy; Alethea B. Tabor; Gabriella T. Heller; Christian D. Lorenz; D. Flemming Hansen. "An integrative characterisation of prolinecisandtransconformers in a disordered peptide". 2024. https://doi.org/10.1101/2024.05.14.594077.
    10.1101/2024.05.14.594077
  2. Gabriella T. Heller; Vaibhav Kumar Shukla; Angelo M. Figueiredo; D. Flemming Hansen. "Small-molecule binding to an intrinsically disordered protein revealed by experimental NMR19F transverse spin-relaxation". 2023. https://doi.org/10.1101/2023.05.03.539297.
    10.1101/2023.05.03.539297
Report
  1. Figueiredo, Angelo M; Cabrita, Eurico J.. 2013. GLOBAL ACTIVITY REPORT (Portuguese Nuclear Magnetic Resonance Network, PTNMR 2010-2012). http://ptnmr.dq.ua.pt/images/Global-Activity-Report-PTNMR-2010-2012.pdf.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/24 Latest developments & applications of Artificial Intelligence (AI) in NMR Spectroscopy - Deep Learning Tools in NMR Annual meeting of UK Magnetic Resonance Facilities (UKMRM)
Royal Society of Chemistry, University of Birmingham (Birmingham, United Kingdom)
2019/07/17 A NMR approach to characterise guanidino group of arginine side chains at macromolecular protein interfaces XXV Portuguese Chemical Meeting
Sociedade Portuguesa Química (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017/01/01 - Current NMR investigation of osmolytes modulation of protein structure and dynamics and its relation to protein misfolding diseases
Co-supervisor
 MolBio (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2013/01/01 - Current 3rd Hands on course NMR based protein interaction studies (2013)
Workshop
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/01/01 - Current 2nd Hands on course on ligand based NMR interactions studies (2011/01/02)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/04/14 - 2018/04/16 COST CM1306 WG3 Workshop – Emerging Magnetic Resonance Techniques to Study Dynamic Molecular Machines (2018/04/14)
Workshop (Other)
2012/12/18 - 2012/12/20 To provide theoretical and practical training in important aspects of aligned media for structural elucidation of small molecules and the measurement of residual dipolar couplings (RDC) in NMR spectroscopy (2012/12/18 - 2012/12/20)
Workshop (Co-organisor)
 Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/06/30 - 2024/07/05 Poster Presentation - The effect of the ribosome on the conformational ensemble of an unfolded nascent chain
Congress
 20th European Magnetic Resonance Congress
Real Sociedad Espanola de Quimica, Spain

CIC bioGUNE, Spain

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014 - Current European Instruct Course/COST course on Integrative Structural Biology tools for the study of protein-ligand interactions (Outros) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2020/04/30 Biomolecular NMR Protein Structure and Function Module (BIOC0029) (Bachelor) University College London Division of Biosciences, United Kingdom