Rafael António Vale Lopes Neiva (1E1B-44A2-1FFB)

Curriculum Vitae

Rafael António Vale Lopes Neiva

Rafael Neiva graduated in Biomedical Science with a minor in Molecular Biomedicine, from the University of Aveiro, and concluded his master's degree in Biochemistry at the University of Porto (FCUP/ICBAS), Portugal. Since the conclusion of his Master's degree he integrated Professor Paulo Correia-de-Sá's research group to pursue his research. The research developed, performed in the field of Neuropharmacology, focused on the differential role of methylprednisolone on neurotransmitters GABA and Glutamate release from isolated nerve terminals (synaptosomes) of the rat hippocampus. From September 2020 to March 2022, he worked as a researcher in the project "Unravelling the cellular and molecular cardiopulmonary benefits of DBH inhibition in animals with pulmonary arterial hypertension", funded by BIAL-Portela & Cª, SA, undergoing in Professor Paulo Correia-de-Sá's laboratory. For the past three years he is working on his PhD, furthering his research in pulmonary arterial hypertension. The research project, in the field of cardiac pharmacology, focused on the “Role of the purinome in the crosstalk between cardiomyocytes and fibroblasts underlying right ventricle remodeling in pulmonary arterial hypertension”.

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Identification

Personal identification

Full name: Rafael António Vale Lopes Neiva
Date of birth: 1995/06/14
Gender: Male

Citation names

Neiva, Rafael

Author identifiers

Ciência ID: 1E1B-44A2-1FFB
ORCID iD: 0000-0002-2271-7075

Email addresses

rafael_neiva18@hotmail.com (Personal)

Addresses

Instituto de Ciências Biomédicas de Abel Salazar - Universidade do Porto. Laboratório de Farmacologia e Neurobiologia, MedInUP, ICBAS - Univ. Porto, R. Jorge Viterbo Ferreira, 228, 4050-313, Porto , Porto, Portugal (Professional)

Knowledge fields

Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems
Medical and Health Sciences - Basic Medicine - Neurosciences
Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Natural sciences - Biological Sciences - Biochemistry
Medical and Health Sciences - Health Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2022/04/01 - 2025 Ongoing	Programa Doutoral em Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/05 - 2022/09/16 Concluded	Laboratory Animal Science Course - FELASA Accredited Course 020/08F (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2018/12/11 Concluded	Bioquímica (Mestrado) Universidade do Porto, Portugal "Differential Role of Methylprednisolone on GABA and Glutamate Release From Isolated Nerve Terminals of The Rat Hippocampus" (THESIS/DISSERTATION)	18
2013/09/11 - 2016/06/28 Concluded	Ciências Biomédicas (Licenciatura) Major in Biomedicina Molecular Universidade de Aveiro, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2020/01/04 - 2020/09/13	Researcher (Research)	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal
	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal
2019/09/04 - 2020/01/03	Contracted Researcher (Research)	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/01/02 - 2019/08/15	Researcher (Research)	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09/04 - 2018/12/11	Research Trainee (Research)	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2016	Research Trainee (Research)	Universidade de Aveiro Instituto de Biomedicina, Portugal
	Universidade de Aveiro Instituto de Biomedicina, Portugal

Others

	Category Host institution	Employer
2020/09/14 - 2022/03/31	Prestação de serviços especializados de investigação e de experimentação pré-clínica	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal

Projects

Contract

	Designation	Funders
2020/09 - 2021/12/31	Unravelling the cellular and molecular cardiopulmonary benefits of DBH inhibition in animals with pulmonary arterial hypertension PCS/BIAL/001/2019 Researcher Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal	BIALPORT Ongoing
2019/09/04 - 2020/01/03	Papel das jangadas lipídicas na modulação purinérgica e no transporte de neurotransmissores em epiléticos UID/BIM/04308/2019 Research Fellow Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Laboratório de Farmacologia e Neurobiologia do ICBAS, Portugal	Fundação para a Ciência e a Tecnologia Ongoing

Outputs

Publications

Conference poster	Cristiana Ribeiro; Neiva, Rafael; Diogo Silva; Correia-de-Sá, Paulo; Ana Patrícia Fontes-Sousa. "Reduction of heart rate via P2X4 receptor activation as a promising treatment strategy in pulmonary arterial hypertension". Paper presented in 31st European Meeting on Hypertension and Cardiovascular Protection, 2022.
Journal article	Ribeiro, Cristiana; Neiva, Rafael; Silva, Diogo; Correia-De-Sá, Paulo; Fontes-Sousa, Ana Patricia. "REDUCTION OF HEART RATE VIA P2X4 RECEPTOR ACTIVATION AS A PROMISING TREATMENT STRATEGY IN PULMONARY ARTERIAL HYPERTENSION". Journal of Hypertension 40 Suppl 1 (2022): e232-e233. https://doi.org/10.1097/01.hjh.0000837856.50797.ba. 10.1097/01.hjh.0000837856.50797.ba Neiva, Rafael; Caulino-Rocha, Ana; Ferreirinha, Fátima; Lobo, Maria Graça; Correia-de-Sá, Paulo. "Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus". Frontiers in Molecular Neuroscience 13 (2020): http://dx.doi.org/10.3389/fnmol.2020.00146. 10.3389/fnmol.2020.00146
Thesis / Dissertation	Neiva, Rafael. "Differential Role of Methylprednisolone on GABA and Glutamate Release From Isolated Nerve Terminals of The Rat Hippocampus". Master, Universidade do Porto Faculdade de Ciências, 2018.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2025/02/06	Unbalance of pro-fibrotic (P2Y2 and P2Y4) and anti-fibrotic (P2Y11) receptor subtypes may underlie cardiac fibrosis in rats with Pulmonary Arterial Hypertension	SPF meeting 2025 FMUP (Porto, Portugal)
2025/02/06	Upregulation of HIF-1a impairs the chondrogenic differentiation of aged mesenchymal stromal cells by decreasing adenosine formation and unbalancing A2A/A2B receptor tone	SPF meeting 2025 FMUP (Porto, Portugal)
2025/02/05	Myocardial overexpression of Galectin-3, SGLT2 and DPP4 in patients with Tropical Endomyocardial Fibrosis as disease biomarkers and putative drug targets	SPF meeting 2025 FMUP (Porto, Portugal)
2024/02/09	Pro-fibrotic role of adenosine-sensitive P1 receptors in the right ventricle of rats with pulmonary arterial hypertension	SPF meeting 2024 NOVA Medical School (Lisboa, Portugal)
2022/05/04	Reduction of heart rate by ATP via P2X4 purinoceptor activation may counteract cardiac failure caused by Pulmonary Arterial Hypertension	Encontro de Investigação Jovem da Universidade do Porto - IJUP Universidade do Porto (Porto, Portugal)
2022/02/09	The digitalis-like negative chronotropic effect of ATP mediated by P2X4 receptors is conserved in the heart of rats with pulmonary arterial hypertension	SPF meeting 2022 ICBAS, Universidade do Porto (Porto, Portugal)
2021/02	Cannabidiol preferentially affects GABA and glutamate release from immature hippocampal nerve terminals	SPF2021 (Portugal)
2021	Neurochemical effects of cannabidiol on synchronous GABA and glutamate release from nerve terminals of immature vs adult rats	Encontro de Investigação Jovem da Universidade do Porto - IJUP Universidade do Porto (Porto, Portugal)
2019/02/15	Differential role of methylprednisolone on GABA and Glutamate release from isolated nerve terminals of the rat hippocampus	Encontro de Investigação Jovem da Universidade do Porto - IJUP Universidade Do Porto (Porto, Portugal)
2019/02/07	GABA and Glutamate release is differentially affected by methylprednisolone in isolated nerve terminals of the rat hippocampus	SPF Meeting 2019 Instituto de Ciências Biomédicas Abel Salazar (Porto, Portugal)

Event participation

	Activity description Type of event	Event name Institution / Organization
2020/01/04 - 2020/01/10	Seminário no Mestrado em Medicina Legal, Toxicologia Forense - Aditivos usados na indústria alimentar Seminar	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/04 - 2020/01/10	Seminário no Mestrado em Medicina Legal, Toxicologia Forense - Intoxicações por venenos de animais Seminar	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/04 - 2020/01/10	Seminário no Mestrado em Medicina Legal, Toxicologia Forense - Tóxicos voláteis Seminar	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/04 - 2020/01/10	Seminário no Mestrado em Medicina Legal, Toxicologia Forense - Orientação tutorial Seminar	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020/10/07 - 2020/12/16	Aulas práticas lecionadas ao 1º ano do Mestrado em Bioquímica da FCUP/ICBAS no âmbito da unidade curricular de Neuroquímica/neurobiologia sob orientação da Prof. Doutora Graça Lobo (Isolamento de terminais nervosos centrais - Libertação de GABA e Glutamato) e Prof. Doutora Ana Patrícia Sousa (registos miográficos de aurículas e ventrículos isolados)	Bioquímica (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09/18 - 2019/12/22	Aulas práticas lecionadas ao 1º ano do Mestrado em Bioquímica da FCUP/ICBAS no âmbito da unidade curricular de Neuroquímica/neurobiologia sob orientação da Prof. Doutora Graça Lobo - Isolamento de terminais nervosos centrais (Libertação de GABA e Glutamato)	Bioquímica (Mestrado)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal