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JOÃO ANDRÉ SARGENTO ARAÚJO DE FREITAS. Concluiu o Doutoramento em Ciências da Saúde em 2018 pela Universidade de Coimbra Faculdade de Medicina. É Investigador no CNC.IBILI, Professor Auxiliar Convidado na Universidade de Coimbra Faculdade de Medicina e Assistente no Centro Hospitalar e Universitário de Coimbra EPE. Publicou 88 artigos em revistas especializadas. Participa e/ou participou como Investigador responsável em vários projetos na área da Neurologia Vascular. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Doença vascular cerebral; Hemodinâmica Cerebral; Cérebro; Nanopartículas; Regeneração; Acoplamento neurovascular; Melhoria cognitiva; Envelhecimento e demência vascular.
Identification

Personal identification

Full name
JOÃO ANDRÉ SARGENTO ARAÚJO DE FREITAS

Citation names

  • Sargento-Freitas, João

Author identifiers

Ciência ID
1F1B-1635-380C
ORCID iD
0000-0003-4665-5697

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Clinical Neurology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010 - 2018
Concluded
Ciências da Saúde (Doutoramento)
Major in Medicina
Universidade de Coimbra Faculdade de Medicina, Portugal
"Células Progenitoras Endoteliais na Neoangiogenese após Acidente Vascular Cerebral" (THESIS/DISSERTATION)
Aprovado com louvor e distinção por unanimidade
2008 - 2014
Concluded
Neurologista (Título de especialista)
Major in Neurologia
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
19,8
Affiliation

Teaching in Higher Education

Category
Host institution
Employer
2019 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2016 - 2019 Invited Assistant (University Teacher) Universidade de Coimbra, Portugal
2015 - 2016 Assistant (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal

Other Careers

Category
Host institution
Employer
2014 - Current Assistente (Médica) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Positions / Appointments

Category
Host institution
Employer
2021 - Current Secretary General European Society of Neurosonology and Cerebral Hemodynamics, Switzerland

Others

Category
Host institution
Employer
2015 - Current Investigador CNC.IBILI, Portugal
2008/02/01 - 2014/04/04 Neurology residency Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2010/06/28 - 2010/10/01 Neurosonology fellowship under supervision of Carlos A. Molina. Hospital Vall d'Hebron, Spain
Projects

Contract

Designation Funders
2018/07/26 - Current Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet
POCI-01-0145-FEDER-029099
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2017 - Current NANOSTEM: Developing new NANOmaterials for neural STEM cells drug delivery
Principal investigator
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
European Commission
Ongoing
2018/07/26 - 2021/07/25 Melhoria cognitiva no cérebro idoso e demência vascular em humanos através da funcionalização do acoplamento neurovascular: uma estratégia mecanística molecular promovida por nitrito e ácido ascórbico da dieta
PTDC/MED-NEU/29099/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/22 - 2021/06/21 BrainEdition: controlo remoto da edição genética em células estaminais neurais
PTDC/NAN-MAT/28060/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Rodrigues, A.F.; Rebelo, C.; Reis, T.; Sousa, J.A.; Pinho, S.L.C.; Sargento-Freitas, J.; Peça, J.; Ferreira, L.. "Therapeutic Approaches for Stroke: A Biomaterials Perspective". 185-218. 2022.
  2. Varela, R.; Coelho, J.; Bernardo-Castro, S.; Silva, F.; Sargento-Freitas, J.. "Stroke Prognosis: Monitoring the Hemodynamics and Blood Pressure by TCD/TCCS". 505-525. 2021.
  3. Artur Filipe Rodrigues; Catarina Rebelo; Tiago Reis; João André Sousa; Sónia L. C. Pinho; João Sargento-Freitas; João Peça; Lino Ferreira. "Therapeutic Approaches for Stroke: A Biomaterials Perspective". 185–218-185–218. Springer International Publishing, 2021.
    10.1007/978-3-030-81400-7_8
  4. Varela, Ricardo; Beato-Coelho, José; Castro, Sara; Silva, Fernando; Sargento-Freitas, João. "Stroke prognosis: monitoring the hemodynamics and blood pressure by TCD". In Neurosonology In Critical Care (NESCC) - Monitoring the Neurological impact of the critical pathology. 2020.
    Accepted
  5. Cunha, L.; Sargento-Freitas, J.. "Marfan Syndrome". 170-174. 2018.
  6. Sargento-Freitas, J.; Freire-Gonçalves, A.. "How low is "low risk" in atrial fibrillation?". 267-273. 2014.
  7. Sargento-Freitas, J.; Cunha, L.. "The growing prevalence of atrial fibrillation, especially on stroke units". 33-39. 2014.
  8. Azevedo, E.; Sargento-Freitas, J.. "Neurosonology in atrial fibrillation". 107-113. 2014.
  9. Batista, Sónia; Sargento-Freitas, João; Sousa, Lívia. "Tratamento Imunomodulador da esclerose múltipla". In Introdução à Esclerose Múltipla, 327-349. Lisboa, Portugal: Biogen, 2010.
    Published
Conference poster
  1. Catarina Fernandes; Gaspar Pires, Ricardo; João Sousa; Irina Santos; Rita Machado; Carla Cecilia Nunes; Inês Correia; et al. "Thalamic atrophy in Multiple Sclerosis is associated with higher serum GFAP levels and vascular dysfunction". Paper presented in 9th Joint ECTRIMS-ACTRIMS Meeting, 2023.
  2. Machado, Rita; sousa, J. A.; Brás, Ana; Almendra, L.; Nunes, Carla; Machado, Cristina; Rodrigues, Bruno; et al. "Bridging-therapy with intravenous trombolysis does not compromise functional and procedural outcomes in patients with acute stroke by large vessel occlusion.". Paper presented in 7th European Stroke Organisation Conference (ESOC)”, Webinar 2021., 2021.
Journal article
  1. Sousa, J.A.; Sondermann, A.; Bernardo-Castro, S.; Varela, R.; Donato, H.; Sargento-Freitas, J.. "CTA and CTP for Detecting Distal Medium Vessel Occlusions: A Systematic Review and Meta-analysis". American Journal of Neuroradiology 45 1 (2024): 51-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-85182381676&partnerID=MN8TOARS.
    10.3174/ajnr.A8080
  2. Feigin VL; Owolabi MO; World Stroke Organization–Lancet Neurology Commission Stroke Collaboration Group. "Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization-Lancet Neurology Commission.". The Lancet. Neurology (2023): http://europepmc.org/abstract/med/37827183.
    10.1016/s1474-4422(23)00277-6
  3. Pinto MJ; Schon M; Sousa JA; Filipe J; Costa A; Azevedo E; Sargento-Freitas J; et al. "Ultrasonographic Vasospasm and Outcome of Posterior Reversible Encephalopathy and Cerebral Vasoconstriction Syndromes.". Ultraschall in der Medizin (Stuttgart, Germany : 1980) (2023): http://europepmc.org/abstract/med/37832534.
    10.1055/a-2127-9459
  4. Fischer U; Koga M; Strbian D; Branca M; Abend S; Trelle S; Paciaroni M; et al. "Early versus Later Anticoagulation for Stroke with Atrial Fibrillation.". The New England journal of medicine (2023): http://europepmc.org/abstract/med/37222476.
    10.1056/nejmoa2303048
  5. Sousa, J.A.; Bernardes, C.; Bernardo-Castro, S.; Lino, M.; Albino, I.; Ferreira, L.; Brás, J.; et al. "Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target". Frontiers in Aging Neuroscience 15 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85149529867&partnerID=MN8TOARS.
    10.3389/fnagi.2023.1102809
  6. Sousa, J.A.; Alves, I.A.; Donato, H.; Sargento-Freitas, J.. "The Twitter factor: How does Twitter impact #Stroke journals and citation rates?". International Journal of Stroke 18 5 (2023): 586-589. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142743437&partnerID=MN8TOARS.
    10.1177/17474930221136704
  7. Sobral-Pinho, A.; Jorge, A.; Fonseca, P.; Sargento-Freitas, J.; Durães, J.; Martins, A.I.; Macário, M.C.; Lemos, J.. "Sequential and combined central retinal artery occlusion and anterior ischemic optic neuropathy in Fabry’s disease". Journal of Neurology 270 8 (2023): 4103-4106. http://www.scopus.com/inward/record.url?eid=2-s2.0-85153533587&partnerID=MN8TOARS.
    10.1007/s00415-023-11734-x
  8. Bernardo-Castro, S.; Sousa, J.A.; Martins, E.; Donato, H.; Nunes, C.; d’Almeida, O.C.; Castelo-Branco, M.; et al. "The evolution of blood–brain barrier permeability changes after stroke and its implications on clinical outcome: A systematic review and meta-analysis". International Journal of Stroke 18 7 (2023): 783-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-85152248153&partnerID=MN8TOARS.
    10.1177/17474930231166306
  9. Sousa, J.A.; Sondermann, A.; Bernardo-Castro, S.; Varela, R.; Donato, H.; Sargento-Freitas, J.. "Diagnostic accuracy of CT angiography and CT perfusion imaging for detecting distal medium vessel occlusions: Protocol for a systematic review and meta-analysis". PLoS ONE 18 4 April (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85152095706&partnerID=MN8TOARS.
    10.1371/journal.pone.0284116
  10. Marto, J.P.; Strambo, D.; Ntaios, G.; Nguyen, T.N.; Herzig, R.; Czlonkowska, A.; Demeestere, J.; et al. "Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19". Neurology 100 7 (2023): E739-E750. http://www.scopus.com/inward/record.url?eid=2-s2.0-85149298744&partnerID=MN8TOARS.
    10.1212/WNL.0000000000201537
  11. Lino, Miguel M.; Rondão, Tiago; Banerjee, Arnab; Aires, Inês; Rodrigues, Magda; Reis, Tiago; Santinha, António; et al. "Small extracellular vesicles administered directly in the brain promote neuroprotection and decreased microglia reactivity in a stroke mouse model". Nanoscale 15 45 (2023): 18212-18217. http://dx.doi.org/10.1039/d3nr03861k.
    10.1039/d3nr03861k
  12. Ana Dionísio; Rita Gouveia; João Castelhano; Isabel Catarina Duarte; Gustavo C. Santo; João Sargento-Freitas; Miguel Castelo-Branco; Augusto Fusco. "The Neurophysiological Impact of Subacute Stroke: Changes in Cortical Oscillations Evoked by Bimanual Finger Movement". Stroke Research and Treatment (2022): https://doi.org/10.1155/2022/9772147.
    10.1155/2022/9772147
  13. Martins, A.I.; Soares-dos-Reis, R.; Jorge, A.; Duque, C.; Pereira, D.J.; Fontes Ribeiro, C.; Sargento-Freitas, J.; et al. "A 6-month trial of memantine for nystagmus and associated phenomena in oculopalatal tremor". Frontiers in Neurology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85137803894&partnerID=MN8TOARS.
    10.3389/fneur.2022.921341
  14. Sousa, J.A.; Machado, A.R.; Rito-Cruz, L.; Paiva-Simões, J.; Santos-Martins, L.; Bernardo-Castro, S.; Martins, A.I.; et al. "Single-phase CT angiography predicts ASPECTS decay and may help determine when to repeat CT before thrombectomy". Journal of Stroke and Cerebrovascular Diseases 31 12 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139372391&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2022.106815
  15. Sousa, J.A.; Cruz, L.R.; Almendra, L.; Sargento-Freitas, J.. "Recanalisation of an occluded fenestrated branch of a basilar artery". BMJ Case Reports 15 4 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85127518152&partnerID=MN8TOARS.
    10.1136/bcr-2022-249086
  16. Marto, J.P.; Kauppila, L.A.; Jorge, C.; Faustino, P.; Sargento-Freitas, J.; Pereira, L.; Galego, S.; et al. "Acute Myocardial Infarction after Intravenous Thrombolysis for Acute Ischemic Stroke: Case Series and Systematic Review". Journal of Stroke and Cerebrovascular Diseases 31 2 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120956360&partnerID=MN8TOARS.
    10.1016/j.jstrokecerebrovasdis.2021.106244
  17. Custodia, A.; Ouro, A.; Sargento-Freitas, J.; Aramburu-Núñez, M.; Pías-Peleteiro, J.M.; Hervella, P.; Rosell, A.; et al. "Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke". Frontiers in Neurology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85138534291&partnerID=MN8TOARS.
    10.3389/fneur.2022.940682
  18. Dias MC; Dos Reis RS; Santos JV; Nunes AP; Ferreira P; Maia B; Fragata I; et al. "Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal.". Acta medica portuguesa (2021): http://europepmc.org/abstract/med/34499849.
    10.20344/amp.15031
  19. Ferreira J; António N; Cortez-Dias N; Gonçalves LR; Sargento-Freitas J; von Hafe P; Gil V. "Optimizing prognosis in atrial fibrillation: A call to action in Portugal.". Revista portuguesa de cardiologia (2021): http://europepmc.org/abstract/med/34392904.
    10.1016/j.repce.2020.07.022
  20. Cruz L; Silva A; Lopes J; Damas D; Lourenço J; Costa A; Silva F; et al. "Early Cerebrovascular Ultrasonography as a Predictor of Hemorrhagic Transformation After Thrombectomy.". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2021): http://europepmc.org/abstract/med/34157670.
    10.1016/j.jstrokecerebrovasdis.2021.105922
  21. Sara Bernardo-Castro; Inês Albino; Ángela María Barrera-Sandoval; Francesca Tomatis; João André Sousa; Emanuel Martins; Susana Simões; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. https://doi.org/10.3390/life11060482.
    10.3390/life11060482
  22. Paiva L; Coelho J; Barra S; Costa M; Sargento-Freitas J; Cunha L; Gonçalves L. "Non-vitamin K antagonist oral anticoagulation versus left atrial appendage occlusion for primary and secondary stroke prevention after cardioembolic stroke.". Revista portuguesa de cardiologia (2021): http://europepmc.org/abstract/med/34187638.
    10.1016/j.repce.2020.07.020
  23. Shahjouei S; Tsivgoulis G; Farahmand G; Koza E; Mowla A; Vafaei Sadr A; Kia A; et al. "SARS-CoV-2 and Stroke Characteristics: A Report From the Multinational COVID-19 Stroke Study Group.". Stroke (2021): http://europepmc.org/abstract/med/33878892.
    10.1161/strokeaha.120.032927
  24. Paiva L; Coelho J; Barra S; Costa M; Sargento-Freitas J; Cunha L; Gonçalves L. "Non-vitamin K antagonist oral anticoagulation versus left atrial appendage occlusion for primary and secondary stroke prevention after cardioembolic stroke.". Revista portuguesa de cardiologia (2021): http://europepmc.org/abstract/med/33858727.
    10.1016/j.repc.2020.07.021
  25. Tábuas-Pereira M; Galego O; Almeida MR; Tomás J; Félix-Morais R; Silva F; Rodrigues B; Cordeiro G; Sargento-Freitas J. "Apolipoprotein E genotype does not influence the risk of symptomatic hemorrhage in acute ischemic stroke.". Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2021): http://europepmc.org/abstract/med/33992200.
    10.1016/j.jocn.2021.03.014
  26. Ramos-Lopes J; Varela R; Pascoal R; Rodrigues F; Coelho J; Almendra L; Duque C; et al. "Phospholipase A2 and Ischemic Stroke Etiology.". The neurologist (2021): http://europepmc.org/abstract/med/33646986.
    10.1097/nrl.0000000000000329
  27. João Paulo Branco; Filipa Rocha; João Sargento-Freitas; Gustavo C. Santo; António Freire; Jorge Laíns; João Páscoa Pinheiro. "Impact of Post-Stroke Recanalization on General and Upper Limb Functioning: A Prospective, Observational Study". Neurology International (2021): https://doi.org/10.3390/neurolint13010005.
    10.3390/neurolint13010005
  28. Dionísio, A.; Gouveia, R.; Castelhano, J.; Duarte, I.C.; Santo, G.C.; Sargento-Freitas, J.; Duecker, F.; Castelo-Branco, M.. "The Role of Continuous Theta Burst TMS in the Neurorehabilitation of Subacute Stroke Patients: A Placebo-Controlled Study". Frontiers in Neurology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85119426516&partnerID=MN8TOARS.
    10.3389/fneur.2021.749798
  29. Bernardo-Castro S; Sousa JA; Brás A; Cecília C; Rodrigues B; Almendra L; Machado C; et al. "Pathophysiology of Blood-Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery.". Frontiers in neurology (2020): http://europepmc.org/abstract/med/33362697.
    10.3389/fneur.2020.594672
  30. Ferreira J; António N; Cortez-Dias N; Gonçalves LR; Sargento-Freitas J; von Hafe P; Gil V. "Optimizing prognosis in atrial fibrillation: A call to action in Portugal.". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (2020): http://europepmc.org/abstract/med/33243596.
    10.1016/j.repc.2020.07.011
  31. Sara Bernardo-Castro; Helena Donato; Lino Ferreira; João Sargento-Freitas. "Permeability of the blood-brain barrier through the phases of ischaemic stroke and relation with clinical outcome: protocol for a systematic review". BMJ Open (2020): https://doi.org/10.1136/bmjopen-2020-039280.
    10.1136/bmjopen-2020-039280
  32. Cardoso CS; Sousa JA; Simões P; Silva B; Albuquerque A; Esperança A; Cibrão A; et al. "Misdosing of Non-Vitamin K Antagonist Oral Anticoagulants in Primary Care.". Clinical therapeutics (2020): http://europepmc.org/abstract/med/32513496.
    10.1016/j.clinthera.2020.04.008
  33. Tábuas-Pereira M; Beato-Coelho J; Ribeiro J; Nogueira AR; Cruz L; Silva F; Sargento-Freitas J; Cordeiro G; Santana I. "Single Word Repetition Predicts Long-Term Outcome of Aphasia Caused by an Ischemic Stroke.". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2019): http://europepmc.org/abstract/med/31836358.
    10.1016/j.jstrokecerebrovasdis.2019.104566
  34. Beato-Coelho J; Varela R; Almendra L; Carvalho M; Duque C; Patrício M; Sargento-Freitas J; Freire A; Lemos J. "Ischemic Stroke Incidence in Patients With Microvascular Ocular Motor Palsy Versus Patients With Lacunar Ischemic Stroke.". The neurologist (2019): http://europepmc.org/abstract/med/30817489.
    10.1097/nrl.0000000000000213
  35. Fernandes L; Sargento-Freitas J; Milner J; Silva A; Novo A; Gonçalves T; Marinho AV; et al. "Ischemic stroke in patients previously anticoagulated for non-valvular atrial fibrillation: Why does it happen?". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (2019): http://europepmc.org/abstract/med/30879895.
    10.1016/j.repc.2018.06.004
  36. José Leite; Ana Ribeiro; Diana Gonçalves; João Sargento-Freitas; Luís Trindade; Victor Duque. "Cerebral Venous Thrombosis as Rare Presentation of Herpes Simplex Virus Encephalitis". Case Reports in Infectious Diseases (2019): https://doi.org/10.1155/2019/7835420.
    10.1155/2019/7835420
  37. Malhotra K; Safouris A; Goyal N; Arthur A; Liebeskind DS; Katsanos AH; Sargento-Freitas J; et al. "Association of statin pretreatment with collateral circulation and final infarct volume in acute ischemic stroke patients: A meta-analysis.". Atherosclerosis (2019): http://europepmc.org/abstract/med/30708178.
    10.1016/j.atherosclerosis.2019.01.006
  38. "Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial". The Lancet Neurology 17 12 (2018): 1053-1060. http://dx.doi.org/10.1016/s1474-4422(18)30319-3.
    10.1016/s1474-4422(18)30319-3
  39. Tsivgoulis G; Wilson D; Katsanos AH; Sargento-Freitas J; Marques-Matos C; Azevedo E; Adachi T; et al. "Neuroimaging and clinical outcomes of oral anticoagulant-associated intracerebral hemorrhage.". Annals of neurology (2018): http://europepmc.org/abstract/med/30255970.
    10.1002/ana.25342
  40. Martins AI; Sargento-Freitas J; Jesus-Ribeiro J; Correia I; Cardoso L; Gomes JP; Gonçalves M; et al. "Blood Pressure Variability in Acute Ischemic Stroke: The Role of Early Recanalization.". European neurology (2018): http://europepmc.org/abstract/med/30227441.
    10.1159/000492627
  41. Branco JP; Oliveira S; Sargento-Freitas J; Galego O; Cordeiro G; Cunha L; Freire Gonçalves A; Pinheiro J. "Neuroimaging, serum biomarkers, and patient characteristics as predictors of upper limb functioning 12 weeks after acute stroke: an observational, prospective study.". Topics in stroke rehabilitation (2018): http://europepmc.org/abstract/med/30213243.
    10.1080/10749357.2018.1517491
  42. "Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source". New England Journal of Medicine 378 23 (2018): 2191-2201. http://dx.doi.org/10.1056/nejmoa1802686.
    10.1056/nejmoa1802686
  43. Tábuas-Pereira M; Freitas S; Beato-Coelho J; Ribeiro J; Parra J; Martins C; Silva M; et al. "[Aphasia Rapid Test: Translation, Adaptation and Validation Studies for the Portuguese Population].". Acta medica portuguesa (2018): http://europepmc.org/abstract/med/29916357.
    10.20344/amp.9090
  44. Branco JP; Oliveira S; Sargento-Freitas J; Laíns J; Pinheiro J. "Assessing functional recovery in the first six months after acute ischemic stroke: a prospective, observational study.". European journal of physical and rehabilitation medicine (2018): http://europepmc.org/abstract/med/29764094.
    10.23736/s1973-9087.18.05161-4
  45. Sargento-Freitas J; Pereira A; Gomes A; Amorim P; Matos T; Cardoso CMP; Silva F; et al. "STROKE34 Study Protocol: A Randomized Controlled Phase IIa Trial of Intra-Arterial CD34+ Cells in Acute Ischemic Stroke.". Frontiers in Neurology (2018): http://europepmc.org/abstract/med/29867719.
    10.3389/fneur.2018.00302
  46. Ana C Vidal; Paula Banca; Augusto G Pascoal; Gustavo Cordeiro; João Sargento-Freitas; Ana Gouveia; Miguel Castelo-Branco. "Bilateral versus ipsilesional cortico-subcortical activity patterns in stroke show hemispheric dependence". International Journal of Stroke (2018): https://doi.org/10.1177/1747493018767164.
    10.1177/1747493018767164
  47. Galego O; Jesus-Ribeiro J; Baptista M; Sargento-Freitas J; Martins AI; Silva F; Santos GC; et al. "Collateral pial circulation relates to the degree of brain edema on CT 24 hours after ischemic stroke.". The neuroradiology journal (2018): http://europepmc.org/abstract/med/29663853.
    10.1177/1971400918769912
  48. Branco JP; Oliveira S; Sargento-Freitas J; Santos Costa J; Cordeiro G; Cunha L; Freire Gonçalves A; Pinheiro J. "S100ß Protein as a Predictor of Poststroke Functional Outcome: A Prospective Study.". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2018): http://europepmc.org/abstract/med/29571758.
    10.1016/j.jstrokecerebrovasdis.2018.02.046
  49. Beato-Coelho J; Marto JP; Alves JN; Marques-Matos C; Calado S; Araújo J; Cunha L; et al. "Portuguese Observational Study of Ischaemic Stroke in Patients Medicated with Non-Vitamin K Antagonist Oral Anticoagulants.". European neurology (2018): http://europepmc.org/abstract/med/29421803.
    10.1159/000486755
  50. João Sargento-Freitas; Sezin Aday; César Nunes; Miguel Cordeiro; Ana Gouveia; Fernando Silva; Cristina Machado; et al. "Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics". Journal of the Neurological Sciences 385 (2018): 119-125. https://doi.org/10.1016/j.jns.2017.12.028.
    10.1016/j.jns.2017.12.028
  51. Sargento-Freitas J; Aday S; Nunes C; Cordeiro M; Gouveia A; Silva F; Machado C; et al. "Endothelial progenitor cells enhance blood-brain barrier permeability in subacute stroke.". Neurology (2017): http://europepmc.org/abstract/med/29237797.
    10.1212/wnl.0000000000004801
  52. Tábuas-Pereira M; Sargento-Freitas J; Silva F; Parra J; Mendes P; Seara V; Mesquita M; et al. "Intracranial Internal Carotid Artery Wall Calcification in Ischemic Strokes Treated with Thrombolysis.". European neurology (2017): http://europepmc.org/abstract/med/29131095.
    10.1159/000477901
  53. Amorim JM; Pereira D; Rodrigues MG; Beato-Coelho J; Lopes M; Cunha A; Figueiredo S; et al. "Anatomical characteristics of the styloid process in internal carotid artery dissection: Case-control study.". International journal of stroke : official journal of the International Stroke Society (2017): http://europepmc.org/abstract/med/28906206.
    10.1177/1747493017730779
  54. Tábuas-Pereira M; Sargento-Freitas J; Isidoro L; Silva F; Galego O; Nunes C; Cordeiro G; Cunha L. "Neurosonology Accuracy for Isolated Acute Vestibular Syndromes.". Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine (2017): http://europepmc.org/abstract/med/28692175.
    10.1002/jum.14301
  55. Sousa JA; Mendes-Pinto M; Sargento-Freitas J; Silva F; Cecília C; Macário C; Gouveia A; et al. "Cerebrovascular Dissemination in Time and Space as a Predictor of Cardioembolism.". Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2017): http://europepmc.org/abstract/med/28392099.
    10.1016/j.jstrokecerebrovasdis.2017.03.022
  56. Marques-Matos, C.; Alves, J.N.; Marto, J.P.; Ribeiro, J.A.; Monteiro, A.; Araújo, J.; Silva, F.; et al. "POST-NOAC: Portuguese observational study of intracranial hemorrhage on non-vitamin K antagonist oral anticoagulants". International Journal of Stroke 12 6 (2017): 623-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025454072&partnerID=MN8TOARS.
    10.1177/1747493016681021
  57. Gouveia, Ana; Martins, Ana Inês; Sargento-Freitas, João; Almendra, Luciano; Silva, Fernando; Rodrigues, Bruno; Machado, Cristina; Santo, Gustavo; Cunha, Luís. "Nonaneurysmal sulcal subarachnoid hemorrhage in a patient with atherosclerotic intracranial stenosis". International Journal of Clinical Neurosciences and Mental Health 3(Suppl. 1 (2016): S13. http://dx.doi.org/10.21035/ijcnmh.2016.3(suppl.1).s13.
    Published • 10.21035/ijcnmh.2016.3(suppl.1).s13
  58. Martins, Ana Inês; Sargento-Freitas, João; Silva, Fernando; Beato-Coelho, José; Santo, Gustavo; Farinha, Cláudia; Figueira, João; Cunha, Luís. "Neurosonology: a potential diagnostic tool in central retinal vein occlusion". International Journal of Clinical Neurosciences and Mental Health 3(Suppl. 1 (2016): S14. http://dx.doi.org/10.21035/ijcnmh.2016.3(suppl.1).s14.
    Published • 10.21035/ijcnmh.2016.3(suppl.1).s14
  59. Ana Inês Martins; João Sargento-Freitas. "Endovascular therapy in acute stroke: directly to the catheter lab!". International Journal of Clinical Neurosciences and Mental Health 3(Suppl. 1 (2016): S11-S11. http://dx.doi.org/10.21035/ijcnmh.2016.3(suppl.1).s11.
    10.21035/ijcnmh.2016.3(suppl.1).s11
  60. Marques-Matos C; Alves JN; Marto JP; Ribeiro JA; Monteiro A; Araújo J; Silva F; et al. "POST-NOAC: Portuguese observational study of intracranial hemorrhage on non-vitamin K antagonist oral anticoagulants.". (2016): http://europepmc.org/abstract/med/27903938.
  61. Branco JP; Costa JS; Sargento-Freitas J; Oliveira S; Mendes B; Laíns J; Pinheiro J. "[Neuroimaging and Blood Biomarkers in Functional Prognosis after Stroke].". Acta medica portuguesa (2016): http://europepmc.org/abstract/med/28229841.
    10.20344/amp.7411
  62. Vidal AC; Banca P; Pascoal AG; Santo GC; Sargento-Freitas J; Gouveia A; Castelo-Branco M. "Bilateral versus ipsilesional cortico-subcortical activity patterns in stroke show hemispheric dependence.". International journal of stroke : official journal of the International Stroke Society (2016): http://europepmc.org/abstract/med/28004991.
    10.1177/1747493016672087
  63. Perera KS; Vanassche T; Bosch J; Swaminathan B; Mundl H; Giruparajah M; Barboza MA; et al. "Global Survey of the Frequency of Atrial Fibrillation-Associated Stroke: Embolic Stroke of Undetermined Source Global Registry.". (2016): http://europepmc.org/abstract/med/27507860.
    10.1161/strokeaha.116.013378
  64. Martins AI; Sargento-Freitas J; Silva F; Jesus-Ribeiro J; Correia I; Gomes JP; Aguiar-Gonçalves M; et al. "Recanalization Modulates Association Between Blood Pressure and Functional Outcome in Acute Ischemic Stroke.". (2016): http://europepmc.org/abstract/med/27118796.
    10.1161/STROKEAHA.115.012544
  65. Joana Jesus-Ribeiro; João Sargento-Freitas; Mário Sousa; Fernando Silva; António Freire; Cristina Januário. "Substantia nigra hyperechogenicity does not correlate with motor features in Parkinson's disease". Journal of the Neurological Sciences 364 (2016): 9-11. http://dx.doi.org/10.1016/j.jns.2016.03.002.
    10.1016/j.jns.2016.03.002
  66. Ferreira R; Fonseca MC; Santos T; Sargento-Freitas J; Tjeng R; Paiva F; Castelo-Branco M; Ferreira LS; Bernardino L. "Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia.". (2016): http://europepmc.org/abstract/med/27025400.
    10.1039/c5nr09077f
  67. Jesus-Ribeiro J; Freire A; Sargento-Freitas J; Sousa M; Silva F; Moreira F; Cunha MJ; Walter U; Januário C. "Transcranial Sonography and DaTSCAN in Early Stage Parkinson's Disease and Essential Tremor.". (2016): http://europepmc.org/abstract/med/27750247.
  68. Perera, K.S.; Vanassche, T.; Bosch, J.; Giruparajah, M.; Swaminathan, B.; Mattina, K.R.; Berkowitz, S.D.; et al. "Embolic strokes of undetermined source: Prevalence and patient features in the ESUS Global Registry". International Journal of Stroke 11 5 (2016): 526-533. http://www.scopus.com/inward/record.url?eid=2-s2.0-84969941468&partnerID=MN8TOARS.
    10.1177/1747493016641967
  69. Jesus-Ribeiro, J.; Freire, A.; Sargento-Freitas, J.; Sousa, M.; Silva, F.; Moreira, F.; Cunha, M.J.; Walter, U.; Januário, C.. "Transcranial Sonography and Da TSCAN in early stage Parkinson's disease and essential tremor". European Neurology 76 5-6 (2016): 252-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991744267&partnerID=MN8TOARS.
    10.1159/000452216
  70. Sargento-Freitas J; Laranjinha I; Galego O; Rebelo-Ferreira A; Moura B; Correia M; Silva F; et al. "Nocturnal blood pressure dipping in acute ischemic stroke.". (2015): http://europepmc.org/abstract/med/25809341.
    10.1111/ane.12402
  71. Sargento-Freitas J; Silva F; Pego J; Duque C; Cordeiro G; Cunha L. "Cardioembolic stroke in a patient taking Dabigatran Etexilate: the first case report of clinical and pharmacologic resistance.". (2014): http://europepmc.org/abstract/med/25199675.
    10.1016/j.jns.2014.08.038
  72. Gouveia A; Sargento-Freitas J; Penetra J; Silva F; Machado C; Cordeiro G; Cunha L. "Recurrence in intracranial atherosclerotic disease: a stenosis-based analysis.". (2014): http://europepmc.org/abstract/med/25126697.
    10.1016/j.jstrokecerebrovasdis.2014.03.015
  73. Gouveia, Ana; Sargento-Freitas, João; Madaleno, João; Penetra, Joana; Alves-Silva, Fernando; Machado, Cristina; Santo, Gustavo; Cunha, Luís. "Clinical predictors of increased middle cerebral artery pulsatility". International Journal of Clinical Neurosciences and Mental Health 1(Suppl. 1 (2014): S17. http://dx.doi.org/10.21035/ijcnmh.2014.1(suppl.1).s17.
    10.21035/ijcnmh.2014.1(suppl.1).s17
  74. Galego O; Nunes C; Morais R; Sargento-Freitas J; Sales F; Machado E. "Monitoring balloon test occlusion of the internal carotid artery with transcranial Doppler. A case report and literature review.". (2014): http://europepmc.org/abstract/med/24571842.
  75. Gouveia, Ana; Sargento-Freitas, João; Santo, Gustavo; Silva, Fernando; Cunha, Luís. "Extracranial atherosclerosis is not an independent predictor of white matter changes". Cerebrovascular Diseases Jan 2014 37 (2014): 37-37.
    Published
  76. Félix-Morais R; Sargento-Freitas J; Silva F; Cordeiro G; Nunes C; Ribeiro J; Cordeiro M; Moura C; Cunha L. "[Carotid atherosclerosis and white matter hypodensities: a controversial relationship].". (2014): http://europepmc.org/abstract/med/25409213.
  77. Sargento-Freitas, J.; Felix-Morais, R.; Ribeiro, J.; Gouveia, A.; Nunes, C.; Duque, C.; Madaleno, J.; et al. "Different locations but common associations in subcortical hypodensities of presumed vascular origin: Cross-sectional study on clinical and neurosonologic correlates". BMC Neurology 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893204654&partnerID=MN8TOARS.
    10.1186/1471-2377-14-24
  78. Parra, J.; Domingues, J.; Sargento-Freitas, J.; Santana, I.. "Extensive intracranial involvement with multiple dissections in a case of giant cell arteritis". BMJ Case Reports (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899648914&partnerID=MN8TOARS.
    10.1136/bcr-2014-204130
  79. Galego, O.; Nunes, C.; Morais, R.; Sargento-Freitas, J.; Sales, F.; Machado, E.. "Monitoring balloon test occlusion of the internal carotid artery with transcranial doppler: A case report and literature review". Neuroradiology Journal 27 1 (2014): 115-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898484713&partnerID=MN8TOARS.
    10.15274/NRJ-2014-10014
  80. Vidal, A.C.; Banca, P.; Pascoal, A.G.; Cordeiro, G.; Sargento-Freitas, J.; Castelo-Branco, M.. "Modulation of cortical interhemispheric interactions by motor facilitation or restraint". Neural Plasticity 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84896921743&partnerID=MN8TOARS.
    10.1155/2014/210396
  81. Félix-Morais, R.; Sargento-Freitas, J.; Silva, F.; Cordeiro, G.; Nunes, C.; Ribeiro, J.; Cordeiro, M.; Moura, C.; Cunha, L.. "Carotid atherosclerosis and white matter hypodensities: A controversial relationship,Aterosclerose carotídea e hipodensidades da substância branca: Uma relação controversa". Acta Medica Portuguesa 27 5 (2014): 581-586. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908410137&partnerID=MN8TOARS.
    10.20344/amp.5100
  82. Félix-Morais, Ricardo; Sargento-Freitas, João; Silva, Fernando; Cordeiro, Gustavo; Nunes, César; Ribeiro, Joana; Cordeiro, Miguel; Moura, Cristina; Cunha, Luis. "Aterosclerose Carotídea e Hipodensidades da Substância Branca: uma Relação Controversa". (2014): http://hdl.handle.net/10316/27659.
  83. Sargento-Freitas J; Silva F; Koehler S; Isidoro L; Mendonça N; Machado C; Cordeiro G; Cunha L. "[Atrial fibrillation in cerebrovascular disease: national neurological perspective].". (2013): http://europepmc.org/abstract/med/23809737.
  84. Sargento-Freitas, J.; Silva, F.; Koehler, S.; Isidoro, L.; Mendonça, N.; Machado, C.; Cordeiro, G.; Cunha, L.. "Atrial fibrillation in cerebrovascular disease: National neurological perspective | Fibrilhação auricular na doença cerebrovascular: A perspectiva neurológica nacional". Acta Medica Portuguesa 26 2 (2013): 86-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878819037&partnerID=MN8TOARS.
  85. Sá, T.; Sargento-Freitas, J.; Pinheiro, V.; Martins, R.; Teixeira, R.; Silva, F.; Mendonça, N.; et al. "CHADS2and CHA2DS2VASc scores as predictors of cardioembolic sources in secondary stroke prevention | CHADS2e CHA2DS2VASc como preditores de fonte cardioembólica em prevenção secundária cerebrovascular". Revista Portuguesa de Cardiologia 32 5 (2013): 373-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880159780&partnerID=MN8TOARS.
    10.1016/j.repc.2012.09.007
  86. Flores, A.; Sargento-Freitas, J.; Pagola, J.; Rodriguez-Luna, D.; Piñeiro, S.; Maisterra, O.; Rubiera, M.; et al. "Arterial Blood Gas Analysis of Samples Directly Obtained Beyond Cerebral Arterial Occlusion During Endovascular Procedures Predicts Clinical Outcome". Journal of Neuroimaging 23 2 (2013): 180-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876345193&partnerID=MN8TOARS.
    10.1111/j.1552-6569.2011.00667.x
  87. Sargento-Freitas, J.; Batista, S.; MacArio, C.; Matias, F.; Sousa, L.. "Clinical predictors of an optimal response to natalizumab in multiple sclerosis". Journal of Clinical Neuroscience 20 5 (2013): 659-662. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876669918&partnerID=MN8TOARS.
    10.1016/j.jocn.2012.04.022
  88. Sargento-Freitas, J.; Pagola, J.; Rubiera, M.; Flores, A.; Silva, F.; Rodriguez-Luna, D.; Pineiro, S.; et al. "Preferential effect of premorbid statins on atherothrombotic strokes through collateral circulation enhancement". European Neurology 68 3 (2012): 171-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865061507&partnerID=MN8TOARS.
    10.1159/000337862
  89. Ribo, M.; Flores, A.; Rubiera, M.; Pagola, J.; Sargento-Freitas, J.; Rodriguez-Luna, D.; Coscojuela, P.; et al. "Extending the time window for endovascular procedures according to collateral pial circulation". Stroke 42 12 (2011): 3465-3469. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856212817&partnerID=MN8TOARS.
    10.1161/STROKEAHA.111.623827

Other

Other output
  1. SARS-CoV-2 and stroke characteristics: A report from the multinational COVID-19 stroke study group. 2020. Shahjouei, S.; Tsivgoulis, G.; Farahmand, G.; Koza, E.; Mowla, A.; Sadr, A.V.; Kia, A.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098612475&partnerID=MN8TOARS.
    10.1101/2020.08.05.20169169
Activities

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2021 - Current Caraterização multimodal e evolução da placa carotídea sintomática no período pós-evento neurológico
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - Current Função Visual a Longo Prazo após Trombose Venosa Cerebral e dos Seios Durais
Co-supervisor
Universidade de Coimbra Faculdade de Medicina, Portugal
2018 - 2023 Expression of Transferrin Receptor and subacute Blood-Brain Barrier Permeability in Stroke
Supervisor of Sara Bernardo Castro
PhD in Health Sciences (PhD)
Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022/10/14 - 2022/10/16 Chair of the 2022 conference of the European Society of Neurosonology and Cerebral Hemodynamics (2022/10/14 - 2022/10/16)
Congress (President of the Organising Committee)

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023 Atendimento no Serviço de Urgência e (Re) Internamentos hospitalares no período de doze meses após o primeiro acidente vascular cerebral, no estudo de base populacional: "Tendência na incidência e prognóstico dos acidentes neurológicos” - o segundo estudo de base populacional no norte de Portugal (ACIN2).
(Thesis) Main arguer
Pedro Miguel Paredes Abreu (PhD)
Universidade do Porto Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2021 - Current European Society of Neurosonology and Cerebral Hemodynamics Secretary General
2021 - Current Sociedade Portuguesa do Acidente Vascular Cerebral Vice-Presidente
2018 - Current Sociedade Portuguesa de Neurossonologia Presidente
2011 - 2018 Sociedade Portuguesa de Neurossonologia Secretário