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P Pereira (M) (h-index: 41; i10: 68; citations:7700) is currently a Group Leader (since 2016) and the coordinator of the Research Unit Inova4Health and the Associated Laboratory LS4Future at Nova Medical School. Paulo received a PhD in Cell Biology (1997) and the title habilitation (2007) from the University of Coimbra and he also worked at the Division of Clinical Toxicology, University College of London and at Tufts University, Boston, USA. Paulo was the Presidente of the Executive Board of CEDOC- Center for the Study of Chronic Diseases at UNL, Vice-Dean for research at Faculty of Medicine University of Coimbra, Vice-President of the Portuguese Science Foundation (FCT), Portuguese Delegate to ESFRI Research Infrastructures (EC), Portuguese Delegate to the High level Group for Joint Programming Committee (EC), Representative to the General Assembly of the European Science Foundation (ESF), among other national and international positions. P Pereira Published 88 articles in peer reviewed journals. Has published 6 book Chapter(s). Has 1 patent(s) registered. Supervised 6 Postdocs and 25 PhD theses. Has received 2 awards and/or honors. Participates and/or participated as Principal investigator in 18 project(s)/grants with external funding. His research interests include the study of molecular mechanisms of age-related diseases and particularly retinal diseases such as Age-related macular degeneration. P Pereira made important contributions on regulation of proteostasis upon ageing and diseases and particularly on the pivotal role of proteolysis and extracellular vesicles on ageing and age-related diseases.
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Identification

Personal identification

Full name
Paulo Pereira
Date of birth
1967/03/09
Gender
Male

Citation names

  • Pereira, Paulo
  • Paulo C Pereira
  • P C Pereira

Author identifiers

Ciência ID
1F1D-B041-D79F
ORCID iD
0000-0002-9908-2290
Google Scholar ID
https://scholar.google.pt/citations?hl=pt-PT&user=w8GsNC4AAAAJ
Scopus Author Id
7202938155

Knowledge fields

  • Medical and Health Sciences - Basic Medicine
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2007
Concluded
 Vision Sciences (Título de Agregado)
Universidade de Coimbra Faculdade de Medicina, Portugal
1997
Concluded
 Cell Biology (Doutoramento)
Universidade de Coimbra, Portugal
"n/a" (THESIS/DISSERTATION)
 Aproved
1990
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Biochesmitry" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2017 - Current Coordinating Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016 - Current Coordinating Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2008 - 2013 Coordinating Researcher (Research) Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal
2007 - 2012 Principal Investigator (Research) Universidade de Coimbra Centro de Oftalmologia e Ciências da Visão, Portugal
1998 - 2001 Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
1999 - 2000 Visiting Researcher (Research) Tufts University School of Medicine, United States

Teaching in Higher Education

Category
Host institution 		Employer
2016/03/01 - Current Full Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019 Invited Full Professor (University Teacher) Universidade Nova de Lisboa, Portugal
2016 - 2019 Invited Full Professor (University Teacher) Universidade de Coimbra, Portugal
2013 - 2016 Full Professor (University Teacher) Universidade de Coimbra Faculdade de Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022 - Current Coordinator of the research unit iNOVA4Health, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/04/02 - 2022/04/01 President Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2012/01/02 - 2016/03/01 Vice-President Fundação para a Ciência e a Tecnologia, Portugal

Others

Category
Host institution 		Employer
2012 - 2016 Invited Full Professor Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/01 - 2015/02/01 Portuguese Delegate to de ESFRI-European Strategic Forum for Research Infrastructures European Commission, Belgium
2012/01/01 - 2015/02/01 Portuguese Delegate to the High level Group for Joint Programming Committee European Commission, Belgium
2012/01/01 - 2015/02/01 Member of the general assembly of the JRC-Joint Research Center of the European Union European Commission, Belgium
2012/01/01 - 2015/01/02 Portuguese Alternate Delegate for the ERAC-European Research Area Committee European Commission, Belgium
2007/01/01 - 2015/01/02 Coordinator of the Research Class and integrate Master in medicine Universidade de Coimbra Faculdade de Medicina, Portugal
2012/01/03 - 2015/01/01 Portuguese Representative to the General Assembly of the European Science Foundation (ESF) European Science Foundation, France
2012/01/01 - 2015/01/01 Portuguese representative to the Committee for Research Infrastructures in the 7th Framework pPogramme European Union, Belgium
2009/01/01 - 2015 Member of commision of PhD Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological System Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01/01 - 2014/01/01 Coordinator of the Master in Biomedical Research Universidade de Coimbra Faculdade de Medicina, Portugal
2009/11/16 - 2011/11/15 Vice-Dean Universidade de Coimbra Faculdade de Medicina, Portugal
2009/01/01 - 2011/01/01 Coordinator Investigator Universidade de Coimbra Faculdade de Medicina, Portugal
2008/01/01 - 2011/01/01 Director of Centre of Ophthalmology Universidade de Coimbra Faculdade de Medicina, Portugal
2007/01/01 - 2011/01/01 Director of Laboratory for electron microscopy (National Network of electron microscopy) Universidade de Coimbra, Portugal
2002/01/01 - 2011/01/01 Advanced course coordinator: Biology of proteolysis (BEB PhD programme) Universidade de Coimbra Faculdade de Medicina, Portugal
2005 - 2011 Director of the Laboratory for Research in Biology of Ageing Universidade de Coimbra Faculdade de Medicina, Portugal
2001 - 2011 Portuguese supervisor IOBA (Interuniversity PhD Programme in Visual Sciences) Universidade de Coimbra Faculdade de Medicina, Portugal
2000 - 2011 Director of the Laboratory of Bio-imaging and Confocal Universidade de Coimbra Faculdade de Medicina, Portugal
2007/01/01 - 2009/01/01 Member of Board of Directors Universidade de Coimbra Faculdade de Medicina, Portugal
2001 - 2004 Member of GAI (Office for Sicentific Research) Universidade de Coimbra Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2023 - Current Extracellular vesicles are critical players in the transcellular regulation of proteostasis in Age-related Macular Degeneration (Funding: 250 K€)
2022.08649.PTDC
Principal investigator
iNOVA4Health, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - Current The Science of testing for COVID-19: Towards improved diagnostics and better health solutions. 300.000€
02/SAICT/2020-72552
Principal investigator
iNOVA4Health, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluded
2018/10/01 - Current Lysosome dysfunction in age-related diseases
PTDC/MED-PAT/30385/2017
Co-Principal Investigator (Co-PI)
Fundação para a Ciência e a Tecnologia
Concluded
2017/12 - Current iNOVA4Health - UIDB/Multi/04462/2020 and UIDP/Multi/04462/2020 - "Engineered exosomes as new therapeutic tools to restore proteostasis in age-related degenerative diseases" , 50.000€
REF32 2017
Principal investigator
iNOVA4Health
2010 - 2014 "An animal model for age-related changes in proteostasis"
PTDC/SAU-ORG/118694/2010
Principal investigator
Fundação para a Ciência e a Tecnologia
2010/02/01 - 2013 Functional genomics studies of phagocytosis in retinal pigment epithelium
info:eu-repo/grantAgreement/FCT/3599-PPCDT/105175/PT
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
2010 - 2013 Regulation of retinal growth factors secretion by Rab GTPases
PTDC/SAU-OSM/104668/2008
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2013 Tumorigenesis as a working model for the physiological role of HIF-1alpha degradation by chaperone-mediated autophagy
FCT - PTDC/SAU-ORG/113542/2009
Principal investigator
Fundação para a Ciência e a Tecnologia
2009 - 2011 "A new route for endothelial dysfunction on diabetes: From phenotypes to molecules" 2009-2011
FCT - PTDC/SAU-OSM/67498/2006
Principal investigator
Fundação para a Ciência e a Tecnologia
2005 - 2009 FCT - REDE/1510/RME/2005 "Molecular mechanisms of cell damage and ageing"
FCT - REDE/1510/RME/2005
Principal investigator
Fundação para a Ciência e a Tecnologia
2005/03/01 - 2008/03/01 "What HIF? Degradation is better than growth in preventing angiogenesis in diabetic retinopathy"
FCT - POCI/SAU-OBS/57772/2004
Principal investigator
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2004 - 2007 "Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy"
FCT- POCI/SAU-MMO/57216/2004
Principal investigator
Fundação para a Ciência e a Tecnologia
2004 - 2006 "Degradation and subcellular distribution of GLUT1 in endothelial cells following oxidative stress: implications on diabetic retinopathy"
CRUP- British Council B-1/04
Principal investigator
British Council
2002/03/01 - 2005/03/01 Identification and phyisiological role of deubiquitinating enzymes in the lens: A novel function for ubiquitin
FCT – POCTI -
FCT POCTI -
Principal investigator
Universidade de Coimbra, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2005 Degradation of GLUT1 by ubiquitin proteasome pathway as a novel regulatory mechanism for glucose transport on diabetic retinopathy
FCT - POCTI -
Principal investigator
Fundação para a Ciência e a Tecnologia
2002 - 2005 “Identification and phyisiological role of deubiquitinating enzymes in the lens: A novel function for ubiquitin”
FCT – POCTI -
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
1999 - 2001 "Age, diabetes and cataract related changes in ubiquitin - dependent proteolysis in human lens epithelial cells"
FCT - PRAXIS XXI
Principal investigator
Fundação para a Ciência e a Tecnologia
1998 - 2000 "F2-Isoprostanes as Markers of Oxidative Injury in Human retina" 1998
CRUP- British Council B3/98
CRUP- British Council B3/98
Principal investigator
British Council Portugal
Concluded
1997 - 1999 "Implications of cholesterol oxidation in Human cataract formation"
JNICT -PRAXIS XXI
Principal investigator
Fundação para a Ciência e a Tecnologia
Concluded
1998 - 1998 "Age Related Elimination of Oxidized Proteins as Potential Cause of Cataract"
CRUP- British Council B4/98
Principal investigator
British Council

Contract

Designation Funders
2022 - Current EVCA Twinning on Extracellular Vesicles (Funding: 1,2 M€)
Grant agreement ID: 101079264
Co-Principal Investigator (Co-PI)
Horizon 2020
Ongoing
2017/09/01 - 2019/11/30 Correction of lysosomal dysfunction in Retinal Pigmented Epithelial (RPE) cells (325 Keuros)
_
Researcher
Universidade Nova de Lisboa, Portugal

iNOVA4Health, Portugal
Boehringer Ingelheim Auslandsbeteiligungs GmbH
Concluded
Outputs

Publications

Book chapter
  1. Tenreiro, Sandra; Pereira, Paulo; Vieira, Otília V; Guimas Almeida, Claudia; Vicente Miranda, Hugo; Vieira, Helena ; Seabra, Miguel C.. "Age-related diseases: common mechanisms and therapeutic approaches". In "Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata. Lisbon, Portugal: Universidade Nova de Lisboa and Fundação Amélia de Mello, 2021.
  2. Ferreira, J.V.; Pereira, P.; Girao, H.. "Role of Chaperone-Mediated Autophagy in Ageing and Neurodegeneration". In Toxicity and Autophagy in Neurodegenerative Disorders, 25-40. Springer International Publishing, 2015.
    Published • 10.1007/978-3-319-13939-5_2
  3. Cunha-Vaz, José. "4.1. Molecular mechanisms". In Diabetic Retinopathy, 101-125. WORLD SCIENTIFIC, 2010.
    10.1142/9789814304443_0004
  4. Coelho, J.F.J.; Ferreira, P.; Fonseca, A.C.; Fernandes, A.F.; Pereira, P.; Seiça, R.; Gil, M.H.. "Advanced drug delivery systems in diabetes treatment". In Predictive Diagnostics and Personalized Treatment: Dream or Reality, 285-304. Nova Science Publishers, 2009.
  5. Ambrósio, António F.; Pereira, Paulo; Vaz, José Cunha-. "Diabetic Retinopathy, Inflammation, and Proteasome". In Interaction Between Neurons and Glia in Aging and Disease, 475-502. Springer US, 2007.
    10.1007/978-0-387-70830-0_22
Journal article
  1. Ferreira, João Vasco; da Rosa Soares, Ana; Pereira, Paulo. "LAMP2A mediates the loading of proteins into endosomes and selects exosomal cargo". Autophagy 18 9 (2022): 2263-2265. http://dx.doi.org/10.1080/15548627.2022.2092315.
    Published • 10.1080/15548627.2022.2092315
  2. Ferreira, Joao Vasco; da Rosa Soares, Ana; Pereira, Paulo. "Cell Non-autonomous Proteostasis Regulation in Aging and Disease". Frontiers in Neuroscience 16 (2022): http://dx.doi.org/10.3389/fnins.2022.878296.
    Published • 10.3389/fnins.2022.878296
  3. Saba Abdulghani; Ângela Afonso; Mireia Castillo; Javier Martín-Fernández; Inês Franco; Bruna Parreira; Ana Couto; et al. "The Role of Biobanks in the Fight against COVID-19 Pandemic". Acta Médica Portuguesa 35 13 (2022): https://novaresearch.unl.pt/en/publications/d784754a-7bad-46a7-9f39-ac156555ff2e.
    10.20344/amp.17856
  4. Ferreira, João Vasco; da Rosa Soares, Ana; Ramalho, José; Máximo Carvalho, Catarina; Cardoso, Maria Helena; Pintado, Petra; Carvalho, Ana Sofia; et al. "LAMP2A regulates the loading of proteins into exosomes". Science Advances 8 12 (2022): http://dx.doi.org/10.1126/sciadv.abm1140.
    Open access • 10.1126/sciadv.abm1140
  5. Silva, Filipe; Ferreira, Filipa; Faria, Pedro; Sobral, Isa; Rodrigues, Mariana; Pratas, João; Silva, João Filipe; et al. "MYOC Gene Sequencing Analysis in Primary Open-Angle Glaucoma Patients from the Centre Region of Portugal". Acta Médica Portuguesa 34 9 (2021): 586. http://dx.doi.org/10.20344/amp.14922.
    Open access • Published • 10.20344/amp.14922
  6. Pereira, Paulo. "The early dynamics of the SARS-CoV-2 epidemic in Portugal". MedRxiv (2021): https://doi.org/10.1101/2021.02.22.21252216.
    Open access • Published
  7. Borges, Vítor; Isidro, Joana; Cortes-Martins, Helena; Duarte, Sílvia; Vieira, Luís; Leite, Ricardo; Gordo, Isabel; et al. "Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal". Emerging Microbes & Infections 9 1 (2020): 2488-2496. http://dx.doi.org/10.1080/22221751.2020.1844552.
    Open access • Published • 10.1080/22221751.2020.1844552
  8. Joao Vasco Ferreira; Ana Rosa Soares; José S. Ramalho; Teresa Ribeiro-Rodrigues; Catarina Máximo; Mónica Zuzarte; Henrique Girão; Paulo Pereira. "Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis". PLOS ONE 14 10 (2019): e0223790-e0223790. https://doi.org/10.1371/journal.pone.0223790.
    Open access • Published • 10.1371/journal.pone.0223790
  9. Almeida Paiva, Rafael; Martins-Marques, Tania; Jesus, Katia; Ribeiro-Rodrigues, Teresa; Zuzarte, Monica; Silva, Ana; Reis, Liliana; et al. "Ischaemia alters the effects of cardiomyocyte-derived extracellular vesicles on macrophage activation". Journal of Cellular and Molecular Medicine 23 2 (2018): 1137-1151. http://dx.doi.org/10.1111/jcmm.14014.
    Open access • Published • 10.1111/jcmm.14014
  10. Anjo, Sandra I.; Martins-Marques, Tania; Pereira, Paulo; Girão, Henrique; Manadas, Bruno. "Elucidation of the dynamic nature of interactome networks: A practical tutorial". Journal of Proteomics 171 (2018): 116-126. http://dx.doi.org/10.1016/j.jprot.2017.04.011.
    Published • 10.1016/j.jprot.2017.04.011
  11. Bover, O.; Justo, T.; Pereira, P.N.G.; Facucho-Oliveira, J.; Inacio, J.M.; Ramalho, J.S.; Domian, I.J.; Belo, J.A.. "Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells". PLoS ONE 13 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054434702&partnerID=MN8TOARS.
    10.1371/journal.pone.0205108
  12. Catarino, Steve; Pereira, Paulo; Girão, Henrique. "Molecular control of chaperone-mediated autophagy". Essays in Biochemistry 61 6 (2017): 663-674. http://dx.doi.org/10.1042/ebc20170057.
    Published • 10.1042/ebc20170057
  13. Baptista, Rui; Marques, Carla; Catarino, Steve; Enguita, Francisco J; Costa, Marina C; Matafome, Paulo; Zuzarte, Mónica; et al. "MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1". Cardiovascular Research 114 1 (2017): 53-64. http://dx.doi.org/10.1093/cvr/cvx187.
    Open access • Published • 10.1093/cvr/cvx187
  14. Ribeiro-Rodrigues, Teresa M.; Laundos, Tiago L.; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P.; et al. "Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis". Cardiovascular Research 113 11 (2017): 1338-1350. http://dx.doi.org/10.1093/cvr/cvx118.
    Open access • Published • 10.1093/cvr/cvx118
  15. Ramalho, Ana Rita; Toscano, Adriana; Pereira, Paulo; Girão, Henrique; Gonçalves, Lino; Marques, Carla. "Hyperglycemia-induced degradation of HIF-1a contributes to impaired response of cardiomyocytes to hypoxia". Revista Portuguesa de Cardiologia 36 5 (2017): 367-373. http://dx.doi.org/10.1016/j.repc.2016.09.018.
    Open access • Published • 10.1016/j.repc.2016.09.018
  16. Ribeiro, João Carlos; Oliveiros, Bárbara; Pereira, Paulo; António, Natália; Hummel, Thomas; Paiva, António; Silva, Eduardo D.. "Accelerated age-related olfactory decline among type 1 Usher patients". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep28309.
    Open access • Published • 10.1038/srep28309
  17. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 2 (2016): 443-443. http://dx.doi.org/10.1080/15548627.2016.1147886.
    Open access • Published • 10.1080/15548627.2016.1147886
  18. Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://dx.doi.org/10.1080/15548627.2015.1100356.
    Open access • Published • 10.1080/15548627.2015.1100356
  19. Martins-Marques, Tania; Pinho, Maria Joao; Zuzarte, Monica; Oliveira, Carla; Pereira, Paulo; Sluijter, Joost P. G.; Gomes, Celia; Girao, Henrique. "Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin". Journal of Extracellular Vesicles 5 1 (2016): 32538. http://dx.doi.org/10.3402/jev.v5.32538.
    Open access • Published • 10.3402/jev.v5.32538
  20. Martins-Marques, Tania; Anjo, Sandra Isabel; Pereira, Paulo; Manadas, Bruno; Girão, Henrique. "Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart*". Molecular & Cellular Proteomics 14 11 (2015): 3040-3055. http://dx.doi.org/10.1074/mcp.m115.052894.
    Open access • Published • 10.1074/mcp.m115.052894
  21. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Erratum: Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep14888.
    Open access • Published • 10.1038/srep14888
  22. Soares, Ana Rosa; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Ferreira, Joao Vasco; Catarino, Steve; Pinho, Maria João; Zuzarte, Monica; et al. "Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep13243.
    Open access • Published • 10.1038/srep13243
  23. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Pinho, Maria J.; Pereira, Paulo; Girao, Henrique. "Connexin 43 ubiquitination determines the fate of gap junctions: restrict to survive". Biochemical Society Transactions 43 3 (2015): 471-475. http://dx.doi.org/10.1042/bst20150036.
    Published • 10.1042/bst20150036
  24. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Pereira, Paulo; Girão, Henrique. "To beat or not to beat: degradation of Cx43 imposes the heart rhythm". Biochemical Society Transactions 43 3 (2015): 476-481. http://dx.doi.org/10.1042/bst20150046.
    Published • 10.1042/bst20150046
  25. Vasco Ferreira, Joao; Rosa Soares, Ana; Silva Ramalho, Jose; Pereira, Paulo; Girao, Henrique. "K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy". Scientific Reports 5 1 (2015): http://dx.doi.org/10.1038/srep10210.
    Open access • Published • 10.1038/srep10210
  26. Martins-Marques, Tânia; Catarino, Steve; Marques, Carla; Matafome, Paulo; Ribeiro-Rodrigues, Teresa; Baptista, Rui; Pereira, Paulo; Girão, Henrique. "Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs". Biochimie 112 (2015): 196-201. http://dx.doi.org/10.1016/j.biochi.2015.02.020.
    Published • 10.1016/j.biochi.2015.02.020
  27. Martins-Marques, Tania; Catarino, Steve; Zuzarte, Monica; Marques, Carla; Matafome, Paulo; Pereira, Paulo; Girão, Henrique. "Ischaemia-induced autophagy leads to degradation of gap junction protein connexin43 in cardiomyocytes". Biochemical Journal 467 2 (2015): 231-245. http://dx.doi.org/10.1042/bj20141370.
    Published • 10.1042/bj20141370
  28. Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa; Pereira, Paulo; Codogno, Patrice; Girao, Henrique. "Autophagy and Ubiquitination in Cardiovascular Diseases". DNA and Cell Biology 34 4 (2015): 243-251. http://dx.doi.org/10.1089/dna.2014.2765.
    Published • 10.1089/dna.2014.2765
  29. Martins-Marques, T.; Catarino, S.; Marques, C.; Pereira, P.; Girão, H.. "To beat or not to beat: Degradation of Cx43 imposes the heart rhythm". Biochemical Society Transactions 43 (2015): 476-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934934067&partnerID=MN8TOARS.
    10.1042/BST20150046
  30. Fernandes, Rosa; Bento, Carla F.; Matafome, Paulo; Sena, Cristina M.; Seiça, Raquel M.; Pereira, Paulo. "Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia". Canadian Journal of Physiology and Pharmacology 92 12 (2014): 1037-1043. http://dx.doi.org/10.1139/cjpp-2014-0212.
    Published • 10.1139/cjpp-2014-0212
  31. Ribeiro-Rodrigues, Teresa M.; Catarino, Steve; Marques, Carla; Ferreira, João V.; Martins-Marques, Tânia; Pereira, Paulo; Girão, Henrique. "AMSH-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctions". The FASEB Journal 28 11 (2014): 4629-4641. http://dx.doi.org/10.1096/fj.13-248963.
    Open access • Published • 10.1096/fj.13-248963
  32. Crisóstomo, J.; Matafome, P.; Santos-Silva, D.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça, R.. "Methylglyoxal chronic administration promotes diabetes-like cardiac ischaemia disease in Wistar normal rats". Nutrition, Metabolism and Cardiovascular Diseases 23 12 (2013): 1223-1230. http://dx.doi.org/10.1016/j.numecd.2013.01.005.
    Published • 10.1016/j.numecd.2013.01.005
  33. Simões-Correia, Joana; Silva, Diana I.; Melo, Soraia; Figueiredo, Joana; Caldeira, Joana; Pinto, Marta T.; Girão, Henrique; Pereira, Paulo; Seruca, Raquel. "DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo". Human Molecular Genetics 23 8 (2013): 2094-2105. http://dx.doi.org/10.1093/hmg/ddt602.
    Open access • Published • 10.1093/hmg/ddt602
  34. Ferreira, João Vasco; Fôfo, Hugo; Bejarano, Eloy; Bento, Carla Figueira; Ramalho, José S.; Girão, Henrique; Pereira, Paulo. "STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy". Autophagy 9 9 (2013): 1349-1366. http://dx.doi.org/10.4161/auto.25190.
    Open access • Published • 10.4161/auto.25190
  35. Rodrigues, Lisa; Matafome, Paulo; Crisóstomo, Joana; Santos-Silva, Daniela; Sena, Cristina; Pereira, Paulo; Seiça, Raquel. "Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation". Journal of Physiology and Biochemistry 70 1 (2013): 173-184. http://dx.doi.org/10.1007/s13105-013-0291-2.
    Open access • Published • 10.1007/s13105-013-0291-2
  36. Caldeira, Margarida V.; Curcio, Michele; Leal, Graciano; Salazar, Ivan L.; Mele, Miranda; Santos, Ana Rita A.; Melo, Carlos V.; et al. "Excitotoxic stimulation downregulates the ubiquitin–proteasome system through activation of NMDA receptors in cultured hippocampal neurons". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832 1 (2013): 263-274. http://dx.doi.org/10.1016/j.bbadis.2012.10.009.
    Open access • Published • 10.1016/j.bbadis.2012.10.009
  37. Carvalho, A.N.; Marques, C.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Pereira, P.; Gama, M.J.. "Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.". Molecular neurobiology 47 2 (2013): 662-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886087240&partnerID=MN8TOARS.
  38. Francisco, V.; Costa, G.; Figueirinha, A.; Marques, C.; Pereira, P.; Miguel Neves, B.; Celeste Lopes, M.; et al. "Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasome and nuclear factor-¿B pathway inhibition: Contribution of chlorogenic acid". Journal of Ethnopharmacology 148 1 (2013): 126-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878284536&partnerID=MN8TOARS.
    10.1016/j.jep.2013.03.077
  39. Carvalho, Andreia Neves; Marques, Carla; Rodrigues, Elsa; Henderson, Colin J.; Wolf, C. Roland; Pereira, Paulo; Gama, Maria João. "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice". Molecular Neurobiology 47 2 (2012): 662-672. http://dx.doi.org/10.1007/s12035-012-8368-4.
    Open access • Published • 10.1007/s12035-012-8368-4
  40. Bejarano, Eloy; Girao, Henrique; Yuste, Andrea; Patel, Bindi; Marques, Carla; Spray, David C.; Pereira, Paulo; Cuervo, Ana Maria. "Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner". Molecular Biology of the Cell 23 11 (2012): 2156-2169. http://dx.doi.org/10.1091/mbc.e11-10-0844.
    Open access • Published • 10.1091/mbc.e11-10-0844
  41. Sena, Cristina M.; Matafome, Paulo; Crisóstomo, Joana; Rodrigues, Lisa; Fernandes, Rosa; Pereira, Paulo; Seiça, Raquel M.. "Methylglyoxal promotes oxidative stress and endothelial dysfunction". Pharmacological Research 65 5 (2012): 497-506. http://dx.doi.org/10.1016/j.phrs.2012.03.004.
    Published • 10.1016/j.phrs.2012.03.004
  42. Matafome, P.; Santos-Silva, D.; Crisóstomo, J.; Rodrigues, T.; Rodrigues, L.; Sena, C. M.; Pereira, P.; Seiça, R.. "Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity". Archives of Physiology and Biochemistry 118 2 (2012): 58-68. http://dx.doi.org/10.3109/13813455.2012.658065.
    Published • 10.3109/13813455.2012.658065
  43. Catarino, Steve; Bento, Carla F.; Brito, Ana; Murteira, Eliana; Fernandes, Alexandre F.; Pereira, Paulo. "Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells". Acta Ophthalmologica 90 4 (2012): e255-e263. http://dx.doi.org/10.1111/j.1755-3768.2011.02350.x.
    Open access • Published • 10.1111/j.1755-3768.2011.02350.x
  44. Catarino, Steve; Ramalho, José S.; Marques, Carla; Pereira, Paulo; Girão, Henrique. "Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal". Biochemical Journal 437 2 (2011): 255-267. http://dx.doi.org/10.1042/bj20102059.
    Published • 10.1042/bj20102059
  45. Bento, C. F.; Pereira, P.. "Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes". Diabetologia 54 8 (2011): 1946-1956. http://dx.doi.org/10.1007/s00125-011-2191-8.
    Open access • Published • 10.1007/s00125-011-2191-8
  46. Fernandes, Rosa; Hosoya, Ken-ichi; Pereira, Paulo. "Reactive oxygen species downregulate glucose transport system in retinal endothelial cells". American Journal of Physiology-Cell Physiology 300 4 (2011): C927-C936. http://dx.doi.org/10.1152/ajpcell.00140.2010.
    Open access • Published • 10.1152/ajpcell.00140.2010
  47. Catarino, S.; Ramalho, J.S.; Marques, C.; Pereira, P.; Girão, H.. "Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal". Biochemical Journal 437 2 (2011): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959687376&partnerID=MN8TOARS.
    10.1042/BJ20102059
  48. C. Nabais; João Gonçalves-Pereira; Paulo Pereira; R. Capote; S. Morbeck; J. Raposo. "Retinopatia diabética e condições associadas que relação? Um estudo em doentes com diabetes mellitus tipo 2". Acta Médica Portuguesa 24 SUPPL.2 (2011): 71-78. https://novaresearch.unl.pt/en/publications/649c2942-185c-4935-997e-59845d12b0f8.
  49. Bento, Carla Figueira; Fernandes, Rosa; Ramalho, José; Marques, Carla; Shang, Fu; Taylor, Allen; Pereira, Paulo. "The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1a for Degradation in the Presence of Methylglyoxal". PLoS ONE 5 11 (2010): e15062. http://dx.doi.org/10.1371/journal.pone.0015062.
    Open access • Published • 10.1371/journal.pone.0015062
  50. Bento, C. F.; Fernandes, R.; Matafome, P.; Sena, C.; Seiça, R.; Pereira, P.. "Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction". Experimental Physiology 95 9 (2010): 955-970. http://dx.doi.org/10.1113/expphysiol.2010.053561.
    Open access • Published • 10.1113/expphysiol.2010.053561
  51. Sena, Cristina M.; Bento, Carla F.; Pereira, Paulo; Seiça, Raquel. "Diabetes mellitus: new challenges and innovative therapies". EPMA Journal 1 1 (2010): 138-163. http://dx.doi.org/10.1007/s13167-010-0010-9.
    Open access • Published • 10.1007/s13167-010-0010-9
  52. Bento, C.F.; Marques, F.; Fernandes, R.; Pereira, P.. "Methylglyoxal alters the function and stability of critical components of the protein quality control". PLoS ONE 5 9 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77958517405&partnerID=MN8TOARS.
    Open access • Published • 10.1371/journal.pone.0013007
  53. Girão, Henrique; Catarino, Steve; Pereira, Paulo. "Eps15 interacts with ubiquitinated Cx43 and mediates its internalization". Experimental Cell Research 315 20 (2009): 3587-3597. http://dx.doi.org/10.1016/j.yexcr.2009.10.003.
    Published • 10.1016/j.yexcr.2009.10.003
  54. Fernandes, Alexandre F.; Bian, Qingning; Jiang, Jian-Kang; Thomas, Craig J.; Taylor, Allen; Pereira, Paulo; Shang, Fu. "Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells". Molecular Biology of the Cell 20 16 (2009): 3690-3699. http://dx.doi.org/10.1091/mbc.e08-10-1068.
    Open access • Published • 10.1091/mbc.e08-10-1068
  55. WU, M; BIAN, Q; LIU, Y; FERNANDES, A; TAYLOR, A; PEREIRA, P; SHANG, F. "Sustained oxidative stress inhibits NF-¿B activation partially via inactivating the proteasome". Free Radical Biology and Medicine 46 1 (2009): 62-69. http://dx.doi.org/10.1016/j.freeradbiomed.2008.09.021.
    Published • 10.1016/j.freeradbiomed.2008.09.021
  56. Fernandes, A.F.; Bian, Q.; Jiang, J.-K.; Thomas, C.J.; Taylor, A.; Pereira, P.; Shang, F.. "Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells". Molecular Biology of the Cell 20 16 (2009): 3690-3699. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949098489&partnerID=MN8TOARS.
    10.1091/mbc.E08-10-1068
  57. Zhang, Xinyu; Zhou, Jilin; Fernandes, Alexandre F.; Sparrow, Janet R.; Pereira, Paulo; Taylor, Allen; Shang, Fu. "The Proteasome: A Target of Oxidative Damage in Cultured Human Retina Pigment Epithelial Cells". Investigative Opthalmology & Visual Science 49 8 (2008): 3622. http://dx.doi.org/10.1167/iovs.07-1559.
    Open access • Published • 10.1167/iovs.07-1559
  58. Fernandes, Alexandre F.; Zhou, Jilin; Zhang, Xinyu; Bian, Qingning; Sparrow, Janet; Taylor, Allen; Pereira, Paulo; Shang, Fu. "Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A potential link between oxidative stress and up-regulation of interleukin-8". Journal of Biological Chemistry 283 30 (2008): 20745-20753. http://dx.doi.org/10.1074/jbc.m800268200.
    Open access • Published • 10.1074/jbc.m800268200
  59. Bian, Q.; Fernandes, A.F.; Taylor, A.; Wu, M.; Pereira, P.; Shang, F.; Bian Q; et al. "Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones". Molecular Vision 14 (2008): 403-412. http://www.scopus.com/inward/record.url?eid=2-s2.0-40649092372&partnerID=MN8TOARS.
    Published
  60. Girao, Henrique; Pereira, Paulo. "The proteasome regulates the interaction between Cx43 and ZO-1". Journal of Cellular Biochemistry 102 3 (2007): 719-728. http://dx.doi.org/10.1002/jcb.21351.
    Published • 10.1002/jcb.21351
  61. Fernandes, Alexandre F.; Guo, Weimin; Zhang, Xinyu; Gallagher, Matthew; Ivan, Mircea; Taylor, Allen; Pereira, Paulo; Shang, Fu. "Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells". Experimental Eye Research 83 6 (2006): 1472-1481. http://dx.doi.org/10.1016/j.exer.2006.07.024.
    Published • 10.1016/j.exer.2006.07.024
  62. Marques, Carla; Guo, Weimin; Pereira, Paulo; Taylor, Allen; Patterson, Cam; Evans, Paul C.; Shang, Fu. "The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones". The FASEB Journal 20 6 (2006): 741-743. http://dx.doi.org/10.1096/fj.05-5080fje.
    Open access • Published • 10.1096/fj.05-5080fje
  63. Fernandes, R.; Ramalho, J.; Pereira, P.. "Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells". Molecular Vision 12 (2006): 1526-1535. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845958531&partnerID=MN8TOARS.
    Published
  64. Fernandes R; Ramalho J; Pereira P. "Oxidative stress upregulates ubiquitin proteasome pathway in retinal endothelial cells.". Molecular vision (2006): http://europepmc.org/abstract/med/17167411.
  65. Gira~o, Henrique; Pereira, Paulo; Taylor, Allen; Shang, Fu. "Subcellular Redistribution of Components of the Ubiquitin–Proteasome Pathway during Lens Differentiation and Maturation". Investigative Opthalmology & Visual Science 46 4 (2005): 1386. http://dx.doi.org/10.1167/iovs.04-0563.
    Open access • Published • 10.1167/iovs.04-0563
  66. Fernandes, R.; Carvalho, A.L.; Kumagai, A.; Seica, R.; Hosoya, K.-I.; Terasaki, T.; Murta, J.; Pereira, P.; Faro, C.. "Downregulation of retinal GLUT1 in diabetes by ubiquitinylation". Molecular Vision 10 (2004): 618-628. https://pubmed.ncbi.nlm.nih.gov/15359219/.
    Open access • Published
  67. Fernandes R; Carvalho AL; Kumagai A; Seica R; Hosoya K; Terasaki T; Murta J; Pereira P; Faro C. "Downregulation of retinal GLUT1 in diabetes by ubiquitinylation.". Molecular vision (2004): http://europepmc.org/abstract/med/15359219.
  68. Marques, Carla; Pereira, Paulo; Taylor, Allen; Liang, Jack N.; Reddy, Venkat N.; Szweda, Luke I.; Shang, Fu. "Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells". The FASEB Journal 18 12 (2004): 1424-1426. http://dx.doi.org/10.1096/fj.04-1743fje.
    Open access • Published • 10.1096/fj.04-1743fje
  69. Girão, Henrique; Catarino, Steve; Pereira, Paulo. "7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells". Cell Communication and Signaling 2 1 (2004): 2. http://dx.doi.org/10.1186/1478-811x-2-2.
    Open access • Published • 10.1186/1478-811x-2-2
  70. Fernandes, R.; Girão, H.; Pereira, P.; Fernandes, Rosa; Girão, Henrique; Pereira, Paulo. "High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism". Journal of Biological Chemistry 279 26 (2004): 27219-27224. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042635556&partnerID=MN8TOARS.
    Published • 10.1074/jbc.M400446200
  71. Girão, Henrique; Pereira, Paulo; Ramalho, José; Quinlan, Roy; Prescott, Alan. "Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases". Experimental Cell Research 291 2 (2003): 502-513. http://dx.doi.org/10.1016/j.yexcr.2003.08.002.
    Published • 10.1016/j.yexcr.2003.08.002
  72. Girão, H.; Shang, F.; Pereira, P.. "7-Ketocholesterol stimulates differentiation of lens epithelial cells". Molecular Vision 9 (2003): 497-501. https://pubmed.ncbi.nlm.nih.gov/14551533/.
    Open access • Published
  73. Girão H; Shang F; Pereira P. "7-ketocholesterol stimulates differentiation of lens epithelial cells.". Molecular vision (2003): http://europepmc.org/abstract/med/14551533.
  74. Pereira, Paulo; Shang, Fu; Hobbs, Marisa; Girão, Henrique; Taylor, Allen. "Lens fibers have a fully functional ubiquitin-proteasome pathway". Experimental Eye Research 76 5 (2003): 623-631. http://dx.doi.org/10.1016/s0014-4835(03)00020-4.
    Published • 10.1016/s0014-4835(03)00020-4
  75. Girão H; Pereira P. "Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells.". Molecular vision 9 (2003): 24-30. https://pubmed.ncbi.nlm.nih.gov/12567182/.
    Open access • Published
  76. Pereira, P.; Shang, F.; Hobbs, M.; Girão, H.; Taylor, A.. "Lens fibers have a fully functional ubiquitin-proteasome pathway". Experimental Eye Research 76 5 (2003): 623-631. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037402905&partnerID=MN8TOARS.
    10.1016/S0014-4835(03)00020-4
  77. Girão, H.; Pereira, P.. "Phosphorylation of connexin 43 acts as a stimuli for proteasome-dependent degradation of the protein in lens epithelial cells". Molecular Vision 9 (2003): 24-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037473023&partnerID=MN8TOARS.
  78. England, Timothy; Beatty, Emily; Rehman, Almas; Nourooz-Zadeh, Jaffar; Pereira, Paulo; O'Reilly, James; Wiseman, Helen; Geissler, Catherine; Halliwell, Barry. "The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects". Free Radical Research 32 4 (2000): 355-362. http://dx.doi.org/10.1080/10715760000300351.
    Published • 10.1080/10715760000300351
  79. England, T.; Beatty, E.; Rehman, A.; Nourooz-Zadeh, J.; Pereira, P.; O'Reilly, J.; Wiseman, H.; Geissler, C.; Halliwell, B.. "The steady-state levels of oxidative DNA damage and of lipid peroxidation (F2-isoprostanes) are not correlated in healthy human subjects". Free Radical Research 32 4 (2000): 355-362. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034023134&partnerID=MN8TOARS.
  80. El-Khoury, A.E.; Pereira, P.C.M.; Borgonha, S.; Basile-Filho, A.; Beaumier, L.; Wang, S.Y.; Metges, C.C.; Ajami, A.M.; Young, V.R.. "Twenty-four-hour oral tracer studies with L-[1-13C]lysine at a low (15 mg · kg-1 · d-1) and intermediate (29 mg · kg-1 · d-1) lysine intake in healthy adults". American Journal of Clinical Nutrition 72 1 (2000): 122-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033922569&partnerID=MN8TOARS.
  81. Nourooz-Zadeh, J.; Pereira, P.; Nourooz-Zadeh, Jaffar; Pereira, Paulo. "F2 isoprostanes, potential specific markers of oxidative damage in human retina". Ophthalmic Research 32 4 (2000): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034025592&partnerID=MN8TOARS.
    Published • 10.1159/000055603
  82. Rehman, Almas; Nourooz-Zadeh, Jaffar; Möller, Wenke; Tritschler, Hans; Pereira, Paulo; Halliwell, Barry. "Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus". FEBS Letters 448 1 (1999): 120-122. http://dx.doi.org/10.1016/s0014-5793(99)00339-7.
    Open access • Published • 10.1016/s0014-5793(99)00339-7
  83. Mota, Maria Carolina; Morgado, António Miguel; Matos, Armanda; Pereira, Paulo; Burrows, Hugh. "Evaluation of a non-invasive fluorescence technique as a marker for diabetic lenses in vivo". Graefe's Archive for Clinical and Experimental Ophthalmology 237 3 (1999): 187-192. http://dx.doi.org/10.1007/s004170050217.
    Open access • Published • 10.1007/s004170050217
  84. Girao, Henrique; Mota, Carolina; Pereira, Paulo. "Cholesterol may act as an antioxidant in lens membranes". Current Eye Research 18 6 (1999): 448-454. http://dx.doi.org/10.1076/ceyr.18.6.448.5273.
    Published • 10.1076/ceyr.18.6.448.5273
  85. Nourooz-Zadeh, Jaffar; Pereira, Paulo. "Age-Related Accumulation of Free Polyunsaturated Fatty Acids in Human Retina". Ophthalmic Research 31 4 (1999): 273-279. http://dx.doi.org/10.1159/000055547.
    Published • 10.1159/000055547
  86. Raguso, C.A.; Pereira, P.; Young, V.R.. "A tracer investigation of obligatory oxidative amino acid losses in healthy, young adults". American Journal of Clinical Nutrition 70 4 (1999): 474-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032853942&partnerID=MN8TOARS.
  87. GIRÃO, HENRIQUE; MOTA, MARIA C.; RAMALHO, JOSE; PEREIRA, PAULO. "Cholesterol Oxides Accumulate in Human Cataracts". Experimental Eye Research 66 5 (1998): 645-652. http://dx.doi.org/10.1006/exer.1998.0465.
    Published • 10.1006/exer.1998.0465
  88. Ramalho, J.S.; Pereira, P.; Marques, C.; Mota, M.C.. "Glycation may increase lens protein susceptibility to oxidation". Investigative Ophthalmology and Visual Science 38 4 (1997): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749118028&partnerID=MN8TOARS.
    Published
  89. Ramalho, José; Marques, Carla; Pereira, Paulo; Mota, M. Carolina. "Crystallin composition of human cataractous lens may be modulated by protein glycation". Graefe's Archive for Clinical and Experimental Ophthalmology 234 S1 (1996): S232-S238. http://dx.doi.org/10.1007/bf02343078.
    Open access • Published • 10.1007/bf02343078
  90. Pereira, P.; Leiria, F.; Fernandes, R.; Ramalno, J.S.; Mota, M.C.. "Implications of membrane oxidative damage in human cataract development". Investigative Ophthalmology and Visual Science 37 3 (1996): S886. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750161452&partnerID=MN8TOARS.
    Published
  91. Girão, H.; Pereira, P.; Ramalho, J.S.; Mota, M.C.. "Cholesterol oxidation in lens membranes: Implications on cataract development". Investigative Ophthalmology and Visual Science 37 3 (1996): S650. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750168122&partnerID=MN8TOARS.
    Published
  92. Ramalho, J.S.; Pereira, P.; Marques, C.; Mota, M.C.. "Cataract in diabetic subjects and oxidative degradation of lens proteins". Investigative Ophthalmology and Visual Science 37 3 (1996): S884. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750187855&partnerID=MN8TOARS.
    Published
  93. Pereira, P.C.; Fernandes, R.; Ramalho, J.S.; Mota, M.C.; Oliveira, C.R.. "A Technical Approach to the Evaluation of Glucose Oxidation: Implications for Diabetic Cataract". Ophthalmic Research 28 5 (1996): 275-283. http://dx.doi.org/10.1159/000267915.
    Published • 10.1159/000267915
  94. Yugay, M.T.; Pereira, P.C.; Leiria, F.; Mota, M.C.. "Oxidative damage to lens membranes induced by metal-catalyzed systems". Ophthalmic Research 28 SUPPL. 1 (1996): 92-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029942546&partnerID=MN8TOARS.
    Published • 10.1159/000267979
  95. Fernandes, R.; Pereira, P.; Ramalho, J.S.; Mota, M.C.; Oliveira, C.R.; Fernandes, Rosa; Pereira, Paulo; et al. "An experimental model for the evaluation of lipid peroxidation in lens membranes". Current Eye Research 15 4 (1996): 395-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029925491&partnerID=MN8TOARS.
    Published • 10.3109/02713689608995830
  96. Ramalho, J.S.; Marques, C.; Pereira, P.C.; Mota, M.C.; Ramalho JS; Marques C; Pereira PC; Mota MC. "Role of glycation in human lens protein structure change". European Journal of Ophthalmology 6 2 (1996): 155-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030035489&partnerID=MN8TOARS.
  97. Pereira, P.C.; Fernandes, R.; Ramalho, J.S.; Mota, M.C.; Oliveira, C.R.. "A technical approach to the evaluation of glucose oxidation: Implications for diabetic cataract". Ophthalmic Research 28 5 (1996): 275-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029857485&partnerID=MN8TOARS.
    10.1159/000267915
  98. Ramalho, J.; Marques, C.; Pereira, P.; Mota, M.C.. "Crystallin composition of human cataractous lens may be modulated by protein glycation". Graefe's Archive for Clinical and Experimental Ophthalmology 234 SUPPL. 1 (1996): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029837384&partnerID=MN8TOARS.
    10.1007/bf02343078
  99. Marques, C.; Ramalho, J. S.; Pereira, P.; Mota, M. C.. "Bendazac decreasesin vitro glycation of human lens crystallins - Decrease of in vitro protein glycation by bendazac". Documenta Ophthalmologica 90 4 (1995): 395-404. http://dx.doi.org/10.1007/bf01268125.
    Open access • Published • 10.1007/bf01268125
  100. Pereira, P.C.; Ramalho, J.S.; Faro, C.J.; Mota, M.C.. "Age-Related Changes in Normal and Cataractous Human Lens Crystallins, Separated by Fast-Performance Liquid Chromatography". Ophthalmic Research 26 3 (1994): 149-157. http://dx.doi.org/10.1159/000267406.
    Published • 10.1159/000267406

Intellectual property

Patent
  1. Pereira, Paulo. 2020. "A method for selective loading of proteins into exosomes and products thereof".

Other

Other output
  1. LAMP2A regulates the loading of proteins into exosomes.. 2021. Ferreira, J.V.; da Rosa Soares, A.; Ramalho, J.; Carvalho, C.M.; Cardoso, M.H.; Pintado, P.; Carvalho, A.S.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113107544&partnerID=MN8TOARS.
    10.1101/2021.07.26.453637
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03 LAMP2A and specific peptide motifs regulate the loading of proteins into exosomes. Extracellular vesicles: friends and foes II.
Weizmann Institute (Rehovot, Israel)
2020 2020-2022 More than 200 oral presentations in national and international conferences and symposia

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - Current Engineered exossomes as putative therapeutic tools in Age-related macular degeneration
Supervisor
2018 - Current T cell differentiation as a core component of multiple sclerosis pathogenesis
Supervisor
2013 - Current Implications of HIF1A selective loading in exosomes in Age-Related Macular Degeneration
Supervisor
 Post Doc (Other)
2016 - 2021 Deadly delivery: unravelling the contribution of microglial exosomes to retinal degeneration in glaucoma
Supervisor
2018 - 2020 Mechanisms Underlying Exosomal Trafficking of the Antiretroviral Factor APOBEC3G: Implications for the Containment and Eradication of HIV-1 Infection
Supervisor
2014 - 2019 A new mechanism for selective protein loading into exosomes
Supervisor
2010 - 2016 Identification of the biological pathways and molecular players involved in pulmonary hypertension associated with mir-424
Supervisor
2011 - 2015 Integrated multisensory approach to Usher Syndrome: from the genotype to a better characterization of the phenotype
Supervisor
2010 - 2015 Unravelling molecular events leading to HIF-1a degradation and endothelial dysfunction in diabetic retinopathy
Supervisor
2010 - 2015 Hypoxia and tumorigenesis in colo-rectal cancer: The role of chaperone mediated autophagy in degradation of HIF-1alpha
Supervisor
2008 - 2013 HIF & CHIPs A new autophagic pathway for the degradation Hif-1a
Supervisor
2008 - 2012 Diabetic microvascular dysfunction: The role of methylglyoxal-induced glycation
Supervisor
2007 - 2012 HIF & CHIPs: a new autophagic pathway for the degradation of HIF-1alpha
Supervisor
2011 - 2011 Role of HIF1A in cell dysfunction in diabetes
Supervisor
 Post Doc (Other)
2010 - 2011 Tumorigenesis as a working model for the physiological role of HIF-1alpha degradation by Chaperone-Mediated Autophagy
Co-supervisor
2010 - 2011 A new mechanism for the regulation of intercellular communication through gap-junctions
Supervisor
 Post Doc (Other)
2010 - 2011 Role of E-Cadherin and protein quality control in gastric cancer
Supervisor
 Post Doc (Other)
2010 - 2011 Glaucoma genetics
Supervisor
 Post Doc (Other)
2008 - 2011 Effect of proteasome inhbition on MPP-induced neurotoxicity. Role of GSTP
Supervisor
2006 - 2011 Regulation of intercellular communication through connexin 43 degradation: implications in diabetic retinopathy
Supervisor
2007 - 2010 Mecanismos de regulação da actividade do proteassoma em condições de excitotoxicidade
Supervisor
 Post-Doc (Other)
2005 - 2010 A new mechanism for regulating intercellular communication through gap-junctions
Supervisor
2005 - 2010 Molecular mechanisms regulating muscular atrophy
Supervisor
2005 - 2010 What Hif? A new breath for cell dysfunction in diabetes
Supervisor
2005 - 2010 Mind the gap: a new molecular model for the intracellular trafficking of connexin 43
Supervisor
2004 - 2010 Implications of telomerase activity in tumor development
Supervisor
2005 - 2009 Implications of VEGF production in neovascularization associated with diabetic retinopathy: implications of the ubiquitin-proteasome pathway
Supervisor
2000 - 2007 Oxidative modifications and protein degradation through the ubiquitin-proteasome pathway
Supervisor
2005 - 2006 Intercellular communication and Cx43 degradation in lens and retina
Supervisor
1998 - 2003 Functional implications of cholesterol oxidation in the formation of cataracts
Supervisor
2000 - 2002 Markers of oxidative damage in diabetes and retinopathy progression
Supervisor
1996 - 1998 Cholesterol oxidation in the formation of cataracts
Supervisor
1995 - 1997 Experimental models for evaluation of oxidative damage in lens membranes
Supervisor

Association member

Society Organization name Role
2012 - 2015 JRC-Joint Research Center of the European Union Member of the general assembly
2009 - 2011 Office for Graduate Studies, Faculty of Medicine, University of Coimbra Member of the Office for Graduate Studies, Faculty of Medicine, University of Coimbra
2001 - 2004 Member of GAI - Office for Scientific Research, University of Coimbra

Committee member

Activity description
Role 		Institution / Organization
2012 - 2015 Member of the Board of Directors of the Portuguese Foundation for Science and Technology (FCT)
Director
 Fundação para a Ciência e a Tecnologia, Portugal
2009 - 2012 Member of the Scientific Council of the Faculty of Medicine, University of Coimbra
Other
 Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2011 Member of the Scientific Board of the Doctoral Programme in Health Sciences, Faculty of Medicine, University of Coimbra Universidade de Coimbra Faculdade de Medicina, Portugal
2009 - 2011 Member of Board of Directors of Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological Systems - Doctoral Programme in Health Sciences, Faculty of Medicine, University of Coimbra
Director
 Universidade de Coimbra Faculdade de Medicina, Portugal
2007 - 2009 Member of Board of Directors Faculty of Medicine, University of Coimbra
Director
 Universidade de Coimbra Faculdade de Medicina, Portugal
Distinctions

Award

2022 Pedagogic innovation – Blended Learning Award
Universidad Autónoma de Madrid, Spain

Università degli Studi di Roma Tor Vergata, Italy

Universidade Nova de Lisboa, Portugal
1992 PhD Fellowship UCL

Other distinction

2006 Fulbright Scholars and Researchers program award