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Diana Cunha-Reis (DCR) is currently a Researcher (Junior Researcher contract, PI/group leader) at Biosystems and Integrative Sciences Institute (BioISI) and Departamento Biologia (DB), Faculty of Sciences, Univ. Lisbon (FCUL), Portugal. She graduated in Biochemistry in 1999 at FCUL and completed her PhD in Biomedical Sciences, Neuroscience Specialty at the Faculty of Medicine, Univ. Lisbon (FMUL), Portugal in 2007 with studies on modulation of hippocampal neurotransmission by VIP and adenosine. During her PhD, she was a visiting fellow at Rudolph-Boehm Institute for Pharmacology and Toxicology, Faculty of Medicine, Univ. Leipzig studying patch-clamp in hippocampal interneurons and Swammerdam Institute for Neurobiology, Faculty of Biology, Univ. Amsterdam, studying neurotransmitter release mechanisms. From 2007 to 2010 DCR was a Neuroscience postdoctoral research fellow at Instituto de Medicina Molecular (IMM), FMUL, Portugal. She obtained her first FCT-funded project as PI in 2009 to study VIP receptors in hippocampal dependent cognition and synaptic plasticity. From January 2012 to December 2017 DCR was a postdoctoral research fellow at Centro de Química e Bioquímica, FCUL, IMM and Clínica Universitária de Neurologia, FMUL, studying therapeutic opportunities for preventing epileptogenesis, cognitive decline and sudden death in mesial temporal lobe epilepsy (MTLE). From 2019-2022 she was PI of an FCT-project studying neuronal membrane and lipid raft remodelling in MTLE. From September 2012 to September 2014, DCR was Invited Assistant Professor (course responsible) in Physiology (Nutrition BSc degree) and Human Physiology at Univ. Lusófona de Humanidades e Tecnologias, Lisbon, Portugal. From September 2019 to November 2022 DCR was Secretary of the Portuguese Physiological Society. From September 2019 to July 2021, she was also a Physiology lecturer and course responsible, Biochemistry BSc, FCUL. From January to December 2023, she was PI of a BioISI/FCT funded project investigating altered lipid raft dynamics following seizures at hippocampal synapses using AFM and microscopy techniques. DCR was evaluator and reporter of the 2019-2024 calls of the Marie Sklodowska Curie (MSCA) European Global Fellowships H2020 / Horizon Europe, the 2013-2014 calls (FP7 and H2020 European commission programs) of the MSCA Initial Training Networks (ITN) and of the 2024 call for Fellowships for Excellent Researchers R2-R4, Recovery and Resilience Plan of the Slovak Republic. DCR is editorial board member of Frontiers in Cellular Neuroscience, Exploration of Neuroprotective Therapy and Neuromarkers. She additionally edited 2 Special Issues in Frontiers in Cellular Neurosciences and Biomedicines. She supervised 9 MSc students, 1 PhD student, 4 graduate research fellows, 5 postdoctoral researchers under FCT-funded projects, 4 Erasmus+ internships and over 10 voluntary researchers. She currently supervises 3MSc students. In the last five years (2019-2024) DCR published 18 abstracts in proceedings of scientific meetings, 7 original research papers as last author (2021, 2022, 2023, 2024) and 3 review/editorial papers as first and corresponding author (2020, 2021, 2023) in international journals, 7 of the first quartile in at least one of the following areas Neuroscience, Pharmacology, Biomedicine or Biology. Finally, DCR further co-authored 10 scientific communications to national or international meetings. Her current research is focused on: 1) The value of VPAC1 VIP receptor antagonists in reversing the plastic changes following seizures in vitro and its contributions to the epileptogenesis process in TLE; 2) Cognitive rescue in TLE and aging using novelty training strategies and VIP receptor ligands; 3) the changes in membrane lipid composition and lipid raft dynamics in TLE and the ability of the ketogenic diet therapy to reverse them and 4) The role of synaptic remodeling in cognitive decline upon aging.
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Identification

Personal identification

Full name
Diana Lina Jerónimo da Cunha Reis

Citation names

  • Cunha-Reis, Diana

Author identifiers

Ciência ID
1F1E-73C0-FD44
ORCID iD
0000-0002-0900-9306
Google Scholar ID
e6U9J70AAAAJ
Researcher Id
F-1689-2011
Scopus Author Id
8571270200

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Behavioural Sciences Biology
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Advanced (C1) Intermediate (B1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2007/06/26
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Major in Neurociências Básicas
Universidade de Lisboa Faculdade de Medicina, Portugal
"VIP increases GABAergic transmission to interneurones and pyramidal cells in the hippocamapus: consequences for pyramidal cell activity and modulation by endogenous adenosine." (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
1999/01
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Modulação pelo péptido vasoactivo intestinal da transmissão sináptica no hipocampo de rato." (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2019/07/01 - Current Contracted Researcher (Research) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2012/09/01 - 2014/07/31 Invited Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal

Positions / Appointments

Category
Host institution 		Employer
2019/10/01 - 2022/11/11 Secretary Sociedade Portuguesa de Fisiologia, Portugal
Sociedade Portuguesa de Fisiologia, Portugal
2019/09/01 - 2021/07/31 Physiology course responsible, Biochemistry BSc Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal

Others

Category
Host institution 		Employer
2018/07/01 - 2022/06/30 PI of the project 'Contribution of neuronal membrane and lipid raft remodeling to the pathophysiology of mesial temporal lobe epilepsy (MTLE): insight into the beneficial effects of the ketogenic diet Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2012/01/01 - 2019/06/30 Postdoctoral research fellow - Evaluating therapeutic opportunities for preventing epileptogenesis, cognitive decline and sudden death in epilepsy (SFRH/BPD/81358/2011). Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/07/01 - 2017/12/31 PI of the project 'Evaluating therapeutic opportunities for preventing sudden death in epilepsy', AIDFM EPI-428, FML, internal funding, 10K€) Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2013/02 - 2016/07 Invited lecturer Physiology Health Sciences degree Universidade de Lisboa Faculdade de Medicina, Portugal
2014/04/01 - 2014/06/01 Evaluator and rapporteur of proposals submitted to the 2014 call of the Marie Curie Initial Training Networks (ITN) program. Horizon 2020 European Innovation Council Fast Track to Innovation, Belgium
2010/02/01 - 2013/07/31 PI of project 'Role of VIP receptors in hippocampal dependent cognition and synaptic plasticity: therapeutic potential of VPAC1 receptor antagonists to ameliorate the cognitive deficits in MTLE' Instituto de Medicina Molecular, Portugal
2012/10/01 - 2013/02/28 Evaluator and rapporteur of proposals submitted to the 2013 call of the Marie Curie Initial Training Networks (ITN) program. European Commission Seventh Framework Programme for Research and Technological Development, Belgium
2011/05/01 - 2011/12/31 Researcher (SARIN Educational Fellowship). Universidade de Lisboa Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
2008/02/01 - 2010/07/31 Invited Lecturer of the Neurochemistry course Universidade de Lisboa Faculdade de Ciências, Portugal
2007/07/01 - 2010/06/30 Postdoctoral research fellow (FCT, SFRH/BPD/34661/2007) at the Institute of Pharmacology and Neurosciences, IMM, ULisboa Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2007/10/01 - 2009/02/15 Invited teaching Assistant (electrophysiology experimental work of the Neuroscience Master Course Universidade de Lisboa Faculdade de Medicina, Portugal
2008/03/01 - 2008/12/15 Member of the Organizing Commitee of the 39th Annual Meeting of Portuguese Pharmacological Society Sociedade Portuguesa de Farmacologia, Portugal
1998/07/15 - 2007/09/15 Invited teaching assistant of the practical intensive course of the Neuroscience discipline Universidade de Lisboa Faculdade de Medicina, Portugal
2000/09/01 - 2006/10/31 PhD Student SFRH/BD/889/2000 at the Faculty of Medicine, Univ. Lisbon, Fac. Biology, Univ. Amsterdam and Faculty of Medicine, Univ. Leipzig Fundação para a Ciência e a Tecnologia, Portugal
2000/09/01 - 2000/12/31 research fellow of the COST B10 Program Universiteit van Amsterdam Swammerdam Institute for Life Sciences, Netherlands
1999/02/01 - 2000/08/31 research fellow GGPXXI/BIC/4437/96 and PRAXIS XXI/BIC/17319/99 Universidade de Lisboa Faculdade de Medicina, Portugal
1997/10/01 - 1999/01/31 undergraduate research fellow PRAXIS XXI/BICJ/17319/99 of PRAXIS 2/2.1/BIA/137/94 Universidade de Lisboa Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2023/12/26 - Current COST TEATIME - Improving biomedical research by automated behaviour monitoring in the animal home-cage
CA20135
Researcher
Helsingin yliopisto, Finland
 European Cooperation in Science and Technology
Ongoing
2018/01/01 - Current Biosystems & Integrative Sciences Institute
UID/Multi/04046/2019
UIDB/04046/2020
UID/Multi/04046/2013
Researcher
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/14 - 2023/12/31 Investigating altered lipid raft dynamics following seizures at hippocampal synapses
P08.C BioISI 2023
Principal investigator
Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/07/01 - 2022/06/30 Contribution of neuronal membrane and lipid raft remodelling to the pathophysiology of mesial temporal lobe epilepsy (MTLE): insight into the beneficial effects of the ketogenic diet therapy.
PTDC/SAU-PUB/28311/2017
LISBOA-01-0145-FEDER-028311
Principal investigator
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade do Porto, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia

Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2018/07 - 2022/06 Contribuição da reorganização das membranas e jangadas lipídicas para a fisiopatologia da epilesia mesial temporal com esclerose do hipocampo (MTLE-HS): relação com o tratamento com dieta cetogénica.
149547PRJ
 Fundação para a Ciência e a Tecnologia
2017/01/01 - 2019/12/31 Center of Chemistry and Biochemistry
UID/Multi/00612/2019
UID/MULTI/00612/2013
UID/MULTI/00612/2013
Post-doc
FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Universidade de Lisboa Centro de Química e Bioquímica, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal

Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02 - 2013/07 Genetic modification of the paraventricular nucleus of the hypothalamus (PVN) and rostroventrolateral medula (RVLM) cells to control hypertension chronically.
Provided by PTCRIS: 109081
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2010/02 - 2013/07 On the role of VIP receptors in hippocampal dependent cognition and synaptic plasticity: evaluation of the therapeutic potential of VPAC1 receptor antagonists to ameliorate the cognitive deficits in TLE
Provided by PTCRIS: 103639
103639
Principal investigator
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/02 - 2013/07 Papel dos receptores para o VIP na aprendizagem e plasticidade sináptica dependente do hipocampo: avaliação do potencial terapeutico de antagonistas dos receptores VPAC1 para mitigar as deficiências cognitivas em na ELT.
103639PRJ
 Fundação para a Ciência e a Tecnologia
2009/10 - 2011/05 Membrane receptors and mediators involved in plastic changes induced by neuronal insults: implications for neuroprotection
Provided by PTCRIS: 68607
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2009/08 Neurotrophins and neuronal communication: fine tuning by adenosine
Provided by PTCRIS: 82305
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2007/07 - 2009/06 Neurotrophins and neuronal communication: fine tuning by adenosine
Provided by PTCRIS: 56332
Researcher
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/08/15 - 2007/06/30 Neurotrophins and neuronal communication: fine tuning by adenosine
POCI/SAU-NEU/56332/2004
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003 - 2006 Modulation of synaptic transmission in interneurons: role of adenosine
POCTI/37398/NSE/2001
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2000/09/01 - 2000/11/20 Modulation by VIP of endogenous amino acid (glutamate, GABA) release from brain synaptosomes and its quantification by reversed-phase HPLC analysis
COST B10 Brain Damage Repair
Research Fellow
Universiteit van Amsterdam, Netherlands

Universiteit van Amsterdam Swammerdam Institute for Life Sciences, Netherlands
European Cooperation in Science and Technology
Concluded

Contract

Designation Funders
2019/07/01 - Current Alternative therapeutic strategies to the treatment of drug-refractory temporal lobe epilepsy
DL 57/2016/CP1479/CT0044
Researcher
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/07/01 - 2025/06/30 Not Available
DL 57/2016/CP1479/CT0044
10.54499/DL57/2016/CP1479/CT0044
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2012/01/01 - 2019/06/30 Evaluating therapeutic opportunities for preventing epileptogenesis, cognitive decline and sudden death in epilepsy
SFRH/BPD/81358/2011
33546DFA
Post-doc Fellow
Universidade de Lisboa Centro de Química e Bioquímica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/03/01 - 2016/09/30 New approaches for preventing epileptogenesis, cognitive decline and sudden death in a rat model of temporal lobe epilepsy: training in novelty exploration tasks and the role of VIP VPAC1 receptors
SFRH/BD/88350/2012
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Cancelled
2010/03/01 - 2010/09/30 Involvement of AMPA receptor phosphorylation in VIP modulation of LTP in hippocampal CA1 area
PTDC/SAU-NEU/103639/2008
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/07/01 - 2010/06/30 Role of VIP containing interneurones in the control of the rat hippocampal circuits during locomotion, exploration and in epilepsy
SFRH/BPD/34661/2007
22310DFA
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2000/09/01 - 2004/12/31 Modulation by vasoactive intestinal peptide (VIP) of GABAergic transmission to interneurones and pyramidal cells in the hippocampus: consequences for pyramidal cell activity and modulation by endogenous adenosine
SFRH/BD/889/2000
PhD Student Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999/02/01 - 2000/08/31 Modulation of hippocampal synaptic transmission and GABA release by VIP
PRAXIS XXI/BIC/17319/99
Research Fellow
Universidade de Lisboa Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2011/04/01 - 2013/02/28 Development and behavioural characterization of a rat model of MTLE
PTDC/SAU-NEU/103639/2008
Supervisor
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Cunha-Reis, Diana. "Zinco: Senhor zinco, proteja essas sinapses!". In Os Elementos em Ciências - Uma viagem pela Tabela Periódica, edited by Ana Mourato; Ana Paula Carvalho; Filomena Martins; Teresa Pamplona. Lisboa, Portugal: Ciências ULisboa, 2020.
    Published
Conference abstract
  1. Caulino-Rocha, Ana; Carlos Nascimento; Amaro-Leal, Ângela; Serpa, Andre; Cunha-Reis, Diana. "Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with synaptic remodeling and hippocampal monoamines. Epilepsia, 64(S2), 227-228 .". Paper presented in 35th International Epilepsy Congress, Dublin, 2023.
    Published
  2. Carmo, A. J.; Cunha-Reis, D.. "Evidence of emergent patterns in GluR1 phosphorylation in theta-burst LTP experiments with data mining tools". Paper presented in Amino Acids (Journal) PROCEEDINGS 12th FORUM OF AMINO ACID, PEPTIDE AND PROTEIN RESEARCH, 1st–5th AUG, BEIJING, 2011.
    Published
  3. Cunha-Reis, D.; Carmo, A. J.. "Correlation of VIP VPAC(1) modulation of GluR1 phosphorylation and inhibition of protein kinases in theta-burst LTP experiments with data mining tools". Paper presented in Amino Acids (Journal) PROCEEDINGS 12th FORUM OF AMINO ACID, PEPTIDE AND PROTEIN RESEARCH, 1st–5th AUG, Beijing, 2011.
    Published
  4. Cunha-Reis, Diana; Rodrigues, Nadia C.; Ribeiro, Joaquim A.. "On the cellular and molecular pathways involved in the inhibition of LTP in the CA1 area of the hippocampus". Paper presented in J Mol Neurosci PROCEEDINGS OF THE 9th INTERNATIONAL SYMPOSIUM ON VIP, PACAP AND RELATED PEPTIDES, 5th -8th OCTOBER 2009, Kagoshima, 2009.
    Published
  5. Cunha-Reis, Diana; Ribeiro, Joaquim A.; Sebastiao, Ana M.. "On the pathways involved in VPAC1 and VPAC2 receptor mediated modulation of GABA release from hippocampal synaptosomes". Paper presented in J Neurochem - PROCEEDINGS OF THE ISN-ESN 2005 MEETING, 21ST-26TH AUGUST 2005, Innsbruck, 2005.
    Published
Conference paper
  1. Cunha-Reis, Diana; Ajuda, Rafael; Alves, Ana Mafalda; Negalho, Margarida. "Impact of aging on brain neurotransmitter balance and basal phosphorylation of channels and enzymes crucial for synaptic plasticity". Paper presented in 3rd International Meeting of the Portuguese Society of Physiology, Frontiers Abstract book, In the press, Porto, 2024.
    In press
  2. Amat-Garcia, Laia; Isabel Silva; Cunha-Reis, Diana. Corresponding author: Cunha-Reis, Diana. "VIP VPAC1 receptors as a target to prevent epileptogenesis and to attenuate cognitive decline in epilepsy". Paper presented in XXIII Meeting of the Federation of European Physiological Societies (FEPS) & XLI Meeting of the Spanish Society for Physiological Sciences, Granada, 2024.
    Published
  3. Guerreiro-Pinto, Vasco; Fernandes, Daniela; Gil, Marta; Bento, Marta; Carvalho-Rosa, JD; Cunha-Reis, Diana. Corresponding author: Cunha-Reis, Diana. "Altered basal phosphorylation levels of synaptic enzymes and glutamate ionotropic receptors across life: influence on hippocampal LTP". Paper presented in XXIII Meeting of the Federation of European Physiological Societies (FEPS) & XLI Meeting of the Spanish Society for Physiological Sciences, Granada, 2024.
    Published
  4. Bento, Marta; Serpa, Andre; Caulino-Rocha, Ana; Seweryn Pawlak; Cunha-Reis, Diana. "VPAC1 and VPAC2 receptors are opposingly altered in the Li2+-pilocarpine model of temporal lobe epilepsy". Paper presented in 2nd International Meeting of the Portuguese Society of Physiology, Coimbra, 2022.
    In press
  5. Cunha-Reis, Diana. "Exploring the role of metaplasticity in synaptic function under physiological conditions and in animal models of aging and epilepsy using integrative approaches". Paper presented in 2nd International Meeting of the Portuguese Society of Physiology, Coimbra, 2022.
    In press
  6. Bento, Marta; Caulino-Rocha, Ana; Cunha-Reis, Diana. "Postweaning development influences synaptic VPAC1 and VPAC2 receptor expression and the expression and phosphorylation of AMPA GluA1 and GluA2 subunits". Paper presented in 2nd International Meeting of the Portuguese Society of Physiology, Coimbra, 2022.
    In press
  7. Laia Amat-Garcia; Nádia Carolina Rodrigues; Carvalho-Rosa, JD; Isabel Silva; Cunha-Reis, Diana. "Profound alterations in hippocampal lipid rafts follow in vitro epileptiform activity, hypoxia and oxygen-glucose deprivation". Paper presented in Neuronus 2022 Meeting, Krakow, 2022.
    Published
  8. Gil, Marta; Caulino-Rocha, Ana; Beatriz Vila-Verde; Diana Reis-Borges; Carlos Nascimento; Cunha-Reis, Diana; Vila-Verde, Beatriz; et al. "Altered synaptic physiology and impaired cognition, response to novelty and motor behavior in a rodent model of accelerated aging". Paper presented in Neuronus 2022 Meeting, Krakow, 2022.
    Published
  9. Gil, Marta; Bento, Marta; Rodrigues, Nádia Carolina; Silva-Cruz, Armando (0000-0002-4403-622X); Cunha-Reis, Diana. "Postweaning development shifts endogenous VPAC1 modulation of LTP induced by theta-burst stimulation". Paper presented in Europhysiology 2022, Copenhagen, 2022.
    Published
  10. Cunha-Reis, Diana. "Mismatch novelty exploration training shaping of hippocampal synaptic plasticity and cognition and the role of disinhibition and VIP expressing interneurons". Paper presented in 55th Annual Congress of SBFIS (Sociedade Brasileira de Fisiologia) - Joint meeting with SPFis, Online, 2020.
    Published
  11. Caulino-Rocha, Ana; Aidil-Carvalho, Fatima; Ribeiro, JA; Cunha-Reis, Diana. "Influence of novelty exploration training on modulation of hippocampal synaptic plasticity by endogenous VIP acting on VPAC1 receptors.". Paper presented in 55th Annual Congress of SBFIS (Sociedade Brasileira de Fisiologia) - Joint meeting with SPFis, Online, 2020.
    Published
  12. José Diogo Carvalho-Rosa; Rodrigues, Nádia Carolina Amorim; Cunha-Reis, Diana; Carvalho-Rosa, JD; Rodrigues, NC. "Endogenous VIP VPAC1 receptor activation during ictal and interictal-like activity induced in vitro by bicuculine and 0-Mg2+ modulates subsequent LTP expression in the rat hippocampus". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019.
    Published
  13. Beatriz Vila-Verde; Diana Reis-Borges; Carlos Nascimento; Diana Cunha-Reis; Cunha-Reis, Diana. "Impaired response to novelty and motor behaviour in the D-Gal rat model of accelerated aging.". Paper presented in Front. Cell. Neurosci. Conference Abstract: XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019.
    Published • 10.3389/conf.fncel.2019.01.00002
  14. Cunha-Reis, D.; Ribeiro, J. A.; Sebastiao, A. M.. "VIP modulates K+-evoked H-3 -GABA release from hippocampal synaptosomes through activation of both VPAC1 and VPAC2 receptors". 2004.
  15. Cunha-Reis, Diana; Sebastiao, Ana M.; Ribeiro, Joaquim A.. "Adenosine modulates the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus". Paper presented in British Pharmacological Society Winter meeting 2000, Cambridge, 2000.
  16. Cunha-Reis, D. L.; Sebastiao, A. M.; Ribeiro, J. A.. "Transduction mechanisms involved in the action of VIP in the rat hippocampus". 2000.
Conference poster
  1. Fernandes, Daniela; Gil, Marta; Cunha-Reis, Diana. "Influence of basal phosphorylation status of AMPA receptors and CaMKII on synaptic plasticity and age-associated cognitive decline". Paper presented in 3rd International Meeting of the Portuguese Society of Physiology, Frontiers Abstract book. In the press., 2024.
  2. Carvalho-Rosa, JD; Rodrigues, NC; Cunha-Reis, Diana. "VPAC1 receptor activation by endogenous VIP during interictal-like activity induced in vitro by 0-Mg2+ influences subsequent LTP expression in the rat hippocampus". Paper presented in 12 FENS Forum of Neuroscience ¿ Virtual Forum, 2020.
  3. Caulino-Rocha, Ana; Nádia C. Rodrigues; Andreia Oliveira; Joaquim A Ribeiro; Cunha-Reis, Diana. "Molecular pathways involved in VIP inhibition of LTP in the CA1 area of the hippocampus". Paper presented in FENS 2020, 2020.
  4. Bento-Oliveira, Andreia; Pereira, Pedro; de Almeida, Rodrigo F.M. ; Amaro-Leal, Ângela; Cunha-Reis, Diana. "Altered synaptic plasticity and lipid raft composition in a rat model of MTLE". Paper presented in Workshop on Integrative approaches in neurodegeneration, 2018.
  5. Leal, Ângela; Cunha-Reis, Diana; Amaro-Leal, Ângela; Amaro-Leal, A; Rocha, I; Cunha-Reis, Diana. "Training in novelty exploration tasks prevents cognitive decline in a rat model of TLE (Poster A-778-0003-00425)". Paper presented in 12th European Congress on Epileptology (Prague, Czech Republic), 2016.
    10.1111/epi.13609
  6. Cunha-Reis, D; Rosa, N; Amaro-Leal, A; Nunes-da-Silva, C; Rocha, I. "Impaired spatial memory and response to novelty in a rat model of metabolic syndrome. ". 2014.
  7. Amaro-Leal, Ângela; Cunha-Reis, Diana. "Preventing epileptogenesis, cognitive decline and sudden death in a rat model of TLE: training in novelty exploration tasks". Paper presented in VII PhD Students Meeting CAML (Portugal), 2013.
  8. Leal, Ângela; Cunha-Reis, Diana. "Cognitive impact of repeated exposure to novel spatial arrangement of objects (Poster 7)". Paper presented in SPE: 10º Congresso Nacional de Etiologia (Portugal), 2013.
  9. Cunha-Reis, Diana. "Contribution of endogenous VIP VPAC1 receptor activation during hypoxia and interictal-like activity induced in vitro by 0-Mg2+ to subsequent changes in LTP expression in the rat hippocampus". Paper presented in IUPS 2013, 2013.
  10. Amaro-Leal, A; Carmo, AJS; Rocha, I; Cunha-Reis, D; Leal, Ângela; Cunha-Reis, Diana. "Repeated exposure to novel spatial arrangement of objects: impact on hippocampal-dependent learning and synaptic plasticity.". Paper presented in IUPS 2013, 2013.
    10.5220/0001051702640268
  11. Cunha-Reis, Diana; Aidil-Carvalho, Fatima; Ribeiro, Joaquim Alexandre. "Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors.". Paper presented in 8th FENS Forum of European Neuroscience – Fens 2012, 2012.
    10.1002/hipo.22316
  12. Carmo, AJ; Amaro-Leal, A; Rocha, I; Cunha-Reis, D. "Hippocampal-dependent learning and synaptic plasticity in rats experiencing repeated exposure to novel spatial arrangement of objects.". Paper presented in 8th Forum of European Neuroscience, 2012.
Journal article
  1. Fatima Aidil-Carvalho; Ana Caulino-Rocha; Joaquim Alexandre Ribeiro; Diana Cunha-Reis. "Mismatch novelty exploration training shifts VPAC1 receptor-mediated modulation of hippocampal synaptic plasticity by endogenous VIP in male rats". Journal of Neuroscience Research (2024): https://doi.org/10.1002/jnr.25333.
    10.1002/jnr.25333
  2. Marta Gil; Ana Caulino-Rocha; Marta Bento; Nádia C. Rodrigues; Armando Silva-Cruz; Joaquim A. Ribeiro; Diana Cunha-Reis. "Postweaning Development Influences Endogenous VPAC1 Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System". Biomolecules (2024): https://doi.org/10.3390/biom14030379.
    10.3390/biom14030379
  3. Nascimento, Carlos; Guerreiro-Pinto, Vasco; Pawlak, Seweryn; Caulino-Rocha, Ana; Amat-Garcia, Laia; Cunha-Reis, Diana. "Impaired Response to Mismatch Novelty in the Li2+-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs". Biomedicines 12 3 (2024): 631. http://dx.doi.org/10.3390/biomedicines12030631.
    10.3390/biomedicines12030631
  4. Marta Bento; Caulino-Rocha, Ana; Joaquim A Ribeiro; Cunha-Reis, Diana; Ana Caulino-Rocha; Joaquim Ribeiro; Diana Cunha-Reis; Bento, Marta; Alexandre Ribeiro, Joaquim. Corresponding author: Cunha-Reis, Diana. "A decrease in GluA1 basal phosphorylation levels may contribute to the enhancement in LTP induced by theta-burst stimulation along postweaning development". IBRO Neuroscience Reports 15 (2023): S304-S304. https://publons.com/wos-op/publon/66800618/.
    Published • 10.1016/J.IBNEUR.2023.08.544
  5. Cunha-Reis, Diana; Vaz, Sandra Henriques; Correia-de-Sá, Paulo. "Editorial: Cellular and molecular targets in epileptogenesis focusing on disease prevention". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1251038.
    10.3389/fncel.2023.1251038
  6. José D. Carvalho-Rosa; Nádia C. Rodrigues; Armando Silva-Cruz; Sandra H. Vaz; Diana Cunha-Reis. "Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity?". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1117697.
    10.3389/fncel.2023.1117697
  7. André Serpa; Marta Bento; Ana Caulino-Rocha; Seweryn Pawlak; Diana Cunha-Reis. "Opposing reduced VPAC1 and enhanced VPAC2 VIP receptors in the hippocampus of the Li2+-pilocarpine rat model of temporal lobe epilepsy". Neurochemistry International 158 (2022): 105383-105383. https://doi.org/10.1016/j.neuint.2022.105383.
    10.1016/j.neuint.2022.105383
  8. Ana Caulino-Rocha; Nádia Carolina Rodrigues; Joaquim Alexandre Ribeiro; Diana Cunha-Reis. "Endogenous VIP VPAC1 Receptor Activation Modulates Hippocampal Theta Burst Induced LTP: Transduction Pathways and GABAergic Mechanisms". Biology 11 5 (2022): 627-627. https://doi.org/10.3390/biology11050627.
    10.3390/biology11050627
  9. Rodrigues, Nádia Carolina; Silva-Cruz, Armando; Caulino-Rocha, Ana; Bento-Oliveira, Andreia; Alexandre Ribeiro, Joaquim. "Hippocampal CA1 theta burst-induced LTP from weaning to adulthood: Cellular and molecular mechanisms in young male rats revisited". European Journal of Neuroscience 54 4 (2021): 5272-5292. http://dx.doi.org/10.1111/ejn.15390.
    10.1111/ejn.15390
  10. Cunha-Reis, Diana. "Corrigendum: VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy". Frontiers in Cellular Neuroscience 15 (2021): http://dx.doi.org/10.3389/fncel.2021.691978.
    10.3389/fncel.2021.691978
  11. D. Cunha-Reis; A. Caulino-Rocha; P. Correia-de-Sá. "VIPergic neuroprotection in epileptogenesis: challenges and opportunities". Pharmacological Research 164 (2021): 105356-105356. https://doi.org/10.1016/j.phrs.2020.105356.
    Published • 10.1016/j.phrs.2020.105356
  12. Cunha-Reis, Diana; Caulino-Rocha, Ana. "VIP Modulation of Hippocampal Synaptic Plasticity: A Role for VIP Receptors as Therapeutic Targets in Cognitive Decline and Mesial Temporal Lobe Epilepsy". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00153.
    Open access • 10.3389/fncel.2020.00153
  13. Diana Cunha-Reis; Joaquim Alexandre Ribeiro; Rodrigo F M de Almeida; Ana M Sebastião. "VPAC1 and VPAC2 receptor activation on GABA release from hippocampal nerve terminals involve several different signalling pathways". British Journal of Pharmacology (2017): https://doi.org/10.1111/bph.14051.
    10.1111/bph.14051
  14. Aidil-Carvalho, M.F.; Carmo, A.J.S.; Ribeiro, J.A.; Cunha-Reis, D.. "Mismatch novelty exploration training enhances hippocampal synaptic plasticity: A tool for cognitive stimulation?". Neurobiology of Learning and Memory 145 (2017): 240-250. http://dx.doi.org/10.1016/j.nlm.2017.09.004.
    Published • 10.1016/j.nlm.2017.09.004
  15. Cunha-Reis, Diana; Aidil-Carvalho, Maria de Fatima; Ribeiro, Joaquim A.. "Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1receptors". Hippocampus 24 11 (2014): 1353-1363. http://dx.doi.org/10.1002/hipo.22316.
    Published • 10.1002/hipo.22316
  16. Cunha-Reis, Diana; Ribeiro, Joaquim A.; Sebastião, Ana M.. "A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+-evoked [3H]-GABA release from rat hippocampal nerve terminals". Neuroscience Letters 430 3 (2008): 207-212. http://dx.doi.org/10.1016/j.neulet.2007.10.037.
    Published • 10.1016/j.neulet.2007.10.037
  17. Cunha-Reis, D.; Fontinha, B.M.; Ribeiro, J.A.; Sebastião, A.M.. "Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus". Neuropharmacology 52 2 (2007): 313-320. http://dx.doi.org/10.1016/j.neuropharm.2006.08.003.
    10.1016/j.neuropharm.2006.08.003
  18. Cunha-Reis, Diana; Fontinha, B. M.; Ribeiro, Joaquim A.; Sebastião, Ana M. "Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus". (2007): http://hdl.handle.net/10451/8275.
    http://dx.doi.org/10.1016/j.neuropharm.2006.08.003
  19. CUNHA-REIS, D.. "VPAC2 Receptor Activation Mediates VIP Enhancement of Population Spikes in the CA1 Area of the Hippocampus". Annals of the New York Academy of Sciences 1070 1 (2006): 210-214. http://dx.doi.org/10.1196/annals.1317.016.
    10.1196/annals.1317.016
  20. Cunha-Reis, Diana; Ribeiro, Joaquim A.; Sebastião, Ana M. "VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus". (2006): http://hdl.handle.net/10451/7598.
    http://dx.doi.org/10.1196/annals.1317.016
  21. Cunha-Reis, Diana; Ribeiro, Joaquim Alexandre; Sebastião, Ana M.. "VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors". Brain Research 1049 1 (2005): 52-60. http://dx.doi.org/10.1016/j.brainres.2005.04.077.
    10.1016/j.brainres.2005.04.077
  22. Cunha-Reis, Diana; Sebastião, Ana M; Wirkner, Kerstin; Illes, Peter; Ribeiro, Joaquim Alexandre. "VIP enhances both pre- and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells". British Journal of Pharmacology 143 6 (2004): 733-744. http://dx.doi.org/10.1038/sj.bjp.0705989.
    10.1038/sj.bjp.0705989
  23. Ribeiro, J. Alexandre; Cunha-Reis, Diana; Lopes, Luisa V.; Coelho, Joana E.; Costenla, Ana Rita; Correia-de-Sá, Paulo; Cunha, Rodrigo A.; de Mendonça, Alexandre; Sebastião, Ana M.. "Adenosine receptor interactions in the hippocampus". Drug Development Research 52 1-2 (2001): 337-345. http://dx.doi.org/10.1002/ddr.1132.
    10.1002/ddr.1132
Preprint
  1. C Nascimento; V Guerreiro-Pinto; S Pawlak; A Caulino-Rocha; L Amat-Garcia; D Cunha-Reis. "Impaired response to mismatch novelty in the Li2+-pilocarpine rat model of TLE: correlation with hippocampal monoaminergic inputs". 2024. https://doi.org/10.1101/2024.02.07.579299.
    10.1101/2024.02.07.579299
  2. Marta Gil; Ana Caulino-Rocha; Marta Bento; Nadia Carolina Rodrigues; Armando Silva-Cruz; Joaquim Alexandre Ribeiro; Diana Cunha-reis. "Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation: a link to maturation of the hippocampal GABAergic system?". 2024. https://doi.org/10.1101/2024.02.18.580862.
    10.1101/2024.02.18.580862
  3. Fatima Aidil-Carvalho; Ana Caulino-Rocha; Joaquim A Ribeiro; Diana Cunha-Reis. "Mismatch novelty exploration training impairs VPAC1 receptor mediated modulation of hippocampal synaptic plasticity by endogenous VIP". 2022. https://doi.org/10.1101/2022.12.21.521348.
    10.1101/2022.12.21.521348
  4. JD Carvalho-Rosa; NC Rodrigues; A Silva-Cruz; SH Vaz; D Cunha-Reis. "Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for lipid raft dynamics in early metaplasticity". 2022. https://doi.org/10.1101/2022.12.06.519267.
    10.1101/2022.12.06.519267
  5. Rodrigues, NC; Silva-Cruz, A; Caulino-Rocha, A; Bento-Oliveira, A; Ribeiro, JA; Cunha-Reis, D. "Cellular and molecular mechanisms involved in LTP induced by mild theta-burst stimulation in hippocampal slices from young male rats: from weaning to adulthood". 2021. https://doi.org/10.1101/2021.04.19.440440.
    10.1101/2021.04.19.440440
  6. Rodrigues, Nadia; Caulino-Rocha, Ana; Ribeiro, Joaquim; Cunha-Reis, Diana. "Tonic activation of VPAC1 receptors by VIP modulates theta-burst induced LTP in the hippocampus: transduction pathways and GABAergic mechanisms.". 2021. http://dx.doi.org/10.22541/au.161787961.10433709/v1.
    10.22541/au.161787961.10433709/v1
Thesis / Dissertation
  1. "Changes in synaptic plasticity and lipid raft composition in the hippocampus induced in vitro by hypoxia and oxygen-glucose deprivation". Degree, Universitat de Girona, 2022.
  2. "Changes in synaptic plasticity and lipid raft composition in the hippocampus in different ages and gender, induced in vitro by epileptiform activity and neuroprotective role of VPAC1 VIP receptor antagonists". Master, Universidade de Lisboa Faculdade de Ciências, 2021. http://hdl.handle.net/10451/51710.
  3. Rosa, José Diogo Carvalho. "Alterações da plasticidade sináptica e da composição de jangadas lipídicas no hipocampo em diferentes idades e sexos assim como induzidas in vitro por atividade epiletiforme e o papel neuroprotetor dos recetores VPAC1 para o VIP". Master, 2021. http://hdl.handle.net/10451/51710.
  4. Araújo, Margarida Nóbrega Campos de Freitas. "Investigating the mechanisms of synaptic dysfunction in late-onset Alzheimer’s disease". Master, 2020. http://hdl.handle.net/10451/48747.
  5. Oliveira, Andreia Bento de. "Changes in synaptic plasticity and lipid raft composition in a rat model of temporal lobe epilepsy". Master, 2018. http://hdl.handle.net/10451/37090.
  6. Martins, Maria Luísa Casanova Alves. "Contribuição da actividade física para a recuperação na epilepsia". Master, 2014. http://hdl.handle.net/10437/5861.
  7. Remígio, Ana Maria Duarte. "Alterações cardiovasculares na epilepsia do lobo temporal". Master, 2014. http://hdl.handle.net/10437/5860.
  8. Cruz, Armando Dulcídio da Silva. "The influence of epilepsy in synaptic plasticity in the hippocampus: neuroprotective role of VIP and its receptors". Master, 2010. http://hdl.handle.net/10451/4546.
  9. Rodrigues, Nádia Carolina Amorim. "Vias de transdução envolvidas no efeito do VIP na LTP na área CA1 do hipocampo". Master, 2009. http://hdl.handle.net/10316/28668.
  10. Cunha-Reis, Diana. "Vasoactive intestinal peptide (VIP) increases GABAergic transmission to interneurones and pyramidal cells in the hippocampus: consequences for pyramidal cell activity and modulation by endogenous adenosine". PhD, Universidade de Lisboa Faculdade de Medicina, 2007.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/11/07 Impact of aging on brain neurotransmitter balance and basal phosphorylation of channels and enzymes crucial for synaptic plasticity 3rd International Meeting of the Portuguese Society of Physiology (Physioma 2024)
Sociedade Portuguesa de Fisiologia (Porto, Portugal)
2024/09/05 VIP VPAC1 receptors as a target to prevent epileptogenesis and to attenuate cognitive decline in epilepsy XXIII Meeting of the Federation of European Physiological Societies (FEPS) & XLI Meeting of the Spanish Society for Physiological Sciences
Spanish Society for Physiological Sciences (Granada, Spain)
2024/05/06 Synaptic plasticity and basal phosphorylation status of synaptic proteins throughout life and in epileptogenesis Neuroforum
Organizing committee (Praga, Czech Republic)
2024/02/11 Alterations in GluA1 and GluN1 basal phosphorylation levels: impact on TBS-induced LTP enhancement along postweaning development? 54th Reunion of The Portuguese Pharmacological Society
Universidade Nova de Lisboa (Lisboa, Portugal)
2023/05/30 Invited lecture - Dynamic changes in VIP VPAC1 and VPAC2 receptor expression during post-weaning development and in epilepsy: relevance for synaptic plasticity’, Spring Hippocampal Research Conference, 28th May-2nd June, 2023, Verona, Italy. Spring Hippocampal Research Conference
Organizing committee (Verona, Italy)
2022/02/11 Postweaning development influences endogenous VPAC1 modulation of LTP induced by theta-burst stimulation 52nd Reunion of The Portuguese Pharmacological Society, Porto, Portugal, 9th -11th February 2022
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2021/10/13 Metaplasticity following brain hyperactivity and brief hypoxia: significance for endogenous neuroprotection Simpósio Brasileiro-Ibérico de Fisiologia – ‘Cellular and molecular pathways controlling homeostasis by the brain’, representing the Portuguese Society of Physiology held at the 56º Congresso Annual da SBFis (Sociedade Brasileira de Fisiologia).
Sociedade Brasileira de Fisiologia (Online, Brazil)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - Current A role for VIP VPAC1 receptors in neuronal and astroglial responses to seizures and subsequent synaptic plasticity events.
Supervisor of Rafael Ajuda
 MSC in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/01 - Current A role for astrocytes in modulation of GABAergic transmission and synaptic plasticity by VIP?
Supervisor of Mafalda Delgado S. Pires
 MSc in Biochemistry and Biomedicine (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/07/15 - Current Preventing epileptogenesis with vasoactive intestinal peptide (VIP) VPAC1 receptor ligands. (waits public defense).
Supervisor of Joana Lopes de Oliveira
 Neurobiology MSc (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2022/02/01 - 2022/07/17 Changes in synaptic plasticity and lipid raft composition induced in vitro by hypoxia and oxygen-glucose deprivation
Supervisor of Laia Amat Garcia
 Biotechnology (Degree)
Universitat de Girona Departament de Biologia, Spain
2019/09/15 - 2021/12/03 Changes in synaptic plasticity, lipid raft composition in the hippocampus in different ages and gender, induced in vitro by epileptiform activity and neuroprotective role of VPAC1 VIP receptor antagonists
Supervisor of José Diogo Carvalho Rosa
 Biologia Humana e Ambiente (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2017/09/01 - 2019/01/31 Changes in synaptic plasticity and lipid raft composition in a rat model of temporal lobe epilepsy MSc thesis Andreia Bento-Oliveira
Supervisor of Andreia Bento de Oliveira
 Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/07/01 - 2018/08/05 Supervision of an IASTE (International Association for the Exchange of Students for Technical Experience) internship of Tania Azem, BSc student in Chemistry (Biology minor, Université Pierre et Marie Curie/Sorbonne Universités)
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/03/01 - 2016/09/30 New approaches for preventing epileptogenesis, cognitive decline and sudden death in a rat model of temporal lobe epilepsy: training in novelty exploration tasks and the role of VIP VPAC1 receptors
Supervisor of Ângela Raquel Amaro Leal
 Neurociências (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2014 Deficiências cognitivas associadas à diabetes mellitus
Supervisor of Mariam Iqbal Haji
Ciências farmacêuticas (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2014 - 2014 Alterações Cardiovasculares na Epilepsia do Lobo Temporal
Supervisor of Ana Maria Remígio
Mestrado Integrado Ciências Farmacêuticas (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2014 - 2014 Contribuição da Actividade Física para a Recuperação na Epilepsia
Supervisor of Maria Luísa Casanova Alves Martins
Mestrado Integrado Ciências Farmacêuticas (Master)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2014 Evaluation of the impact of novelty exploration training tasks on spatial memory in the rat: a primer for potential use in preventing cognitive decline in CNS
Supervisor of Ângela Raquel Amaro Leal
 Neurociências (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2010 The Influence of epilepsy in synaptic plasticity in the hippocampus: Neuroprotective role of VIP and its receptors Bioquímica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 - 2009 Vias de transdução envolvidas no efeito do VIP na LTP na área CA1 do hipocampo
Supervisor of Nádia Carolina Amorim Rodrigues
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007/10/01 - 2008/12/31 Modulation of LTD and depotentiation by VIP receptors and novelty exploration training
Supervisor
 Neurociências (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/11/07 - 2024/11/07 Co-organizer of the symposium on Aging held at the 3rd International Meeting of the Portuguese Society of Physiology (2024/11/07 - 2024/11/08)
Conference (Member of the Scientific Committee)
 Sociedade Portuguesa de Fisiologia, Portugal
2023/07/24 - 2023/07/28 Coordinator of 'Ser Cientista' research activities under the project ¿Surviving an epileptic crisis¿, held from 24-28th July 2023 at the Epilepsy and Aging Lab, BioISI ¿ Biosystems and Integrative Sciences Institute, Ciências, ULisboa. (2023)
Other (Other)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2022/02 - 2022/03 March 2022 - Organizer and participant of the Brain Awareness Week 2019 activities that have taken place from 18th march 2022 at BioISI - Biosystems and Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa. Lectures and practical activities involved over 6 BioISI researchers and colaborators in the fields of Biology, Biochemistry, Biomedical Engineering and Informatics. (http://bioisi.pt/bioisi-hosted-a-high-school-students-visit-within-the-brain-awareness-week). (2022/03/18 - 2022/03/18)
Workshop (President of the Organising Committee)
2019/02/01 - 2019/03/17 February to March 2019 - Organizer and participant of the Brain Awareness Week 2019 activities that have taken place from 11-17th march 2019 at BioISI - Biosystems and Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa. Lectures and practical activities involved over 15 BioISI researchers and colaborators in the fields of Biology, Biochemistry, Biomedical Engineering and Informatics. (http://bioisi.pt/newsletter-april/). (2019/03/11 - 2019/03/17)
Other (President of the Organising Committee)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2011/07/11 - 2011/07/19 Local support to the organizing committee of the 2nd EFAS School (School of Autonomic Neuroscience), 16th-19th June 2011 IMM Lisbon Portugal (2011/07/11 - 2011/07/19)
Workshop (Other)
 Universidade de Lisboa Faculdade de Medicina, Portugal
2010/12/13 - 2010/12/15 Local support to the organizing committee of the 4th Portuguese Mass Spectrometry Meeting, 13th-15th December 2010, FCUL, Portugal (2010/12/11 - 2010/12/13)
Meeting (Other)
 Universidade de Lisboa Faculdade de Ciências, Portugal
2008/01/01 - 2010/06/30 Weekly Neuroscience Seminars at the Neuroscience and Pharmacology Unit, Institute of Molecular Medicine, University of Lisbon (2008/01/01 - 2010/06/30)
Meeting (Member of the Organising Committee)
 Instituto de Medicina Molecular, Portugal
2008/03 - 2008/12 39th Annual meeting of the Portuguese Pharmacological Society (2008/12/03 - 2008/12/05)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Neurociências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/11/12 - Current Co-chair with Professor Telmo Pereira (in substitution of Prof. Ana Fernandes) of the Podium Session for selected meeting presentations at the 2nd International Meeting of the Portuguese Society of Physiology (Physioma 2022), ESTEC, Coimbra, Portugal
Conference
 2nd International Meeting of the Portuguese Society of Physiology (Physioma 2022)
2017/05/31 - Current Poster communication - Cunha-Reis D (2017) Role of endogenous VIP VPAC1 receptor activation during hypoxia and interictal-like activity induced in vitro by 0-Mg2+ in LTP expression in the rat hippocampus.
Meeting
 CQB-Day 2017, CQB, DQB, FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/02/09 - 2024/02/11 Co-chair with Professor Jorge Oliveira of symposium Session XIX at the 54th Reunion of The Portuguese Pharmacological Society held at Lisbon, Portugal, 7th -9th February 2024.
Conference
 54th Reunion of The Portuguese Pharmacological Society
Universidade Nova de Lisboa, Portugal
2020/07/11 - 2020/07/15 Poster communication - Caulino-Rocha A, Rodrigues NC, Bento Oliveira A, Ribeiro JA, Cunha-Reis D (2020) Molecular pathways involved in VIP inhibition of LTP in the CA1 area of the hippocampus. Communication to the 12th FENS Forum of European Neuroscience - Fens 2020, Glasgow, UK, 11th -15th July 2020.
Congress
 12th FENS Forum of European Neuroscience – Fens 2020
Federation of European Neuroscience Societies, Belgium
2020/07/11 - 2020/07/15 Poster communication - Carvalho-Rosa J, Rodrigues NC, Cunha-Reis D (2020) VPAC1 receptor activation by endogenous VIP during interictal-like activity induced in vitro by 0-Mg2+ influences subsequent LTP expression in the rat hippocampus. Communication to the 12th FENS Forum of European Neuroscience - Fens 2020, Glasgow, UK, 11th -15th July 2020.
Congress
 12th FENS Forum of European Neuroscience – Fens 2020
Federation of European Neuroscience Societies, Belgium
2019/10/10 - 2019/10/11 Poster communication - Bento-Oliveira A, Pereira P, Amaro Leal A, Cunha Reis D (2019) Evidence for altered lipid raft composition and synaptic plasticity in a rat model of MTLE. Communication to the 1st International Meeting of The Portuguese Society Of Physiology - Physioma 2019, Lisbon, Portugal, 10th -11th October 2019.
Meeting
 Physioma 2019
Sociedade Portuguesa de Fisiologia, Portugal
2019/02/04 - 2019/02/04 Contributing to discussion on strategies to fund human resources in science .
Conference
 How to support human resources and careers in science?
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2018/12/17 - 2018/12/17 Speaker at Round Table - As carreiras científicas em Portugal: debate com investigadores, docentes e gestores de ciência' at the meeting 'Universidade e trabalho científico' held 17 de Dezembro, FCSH, Univ. Nova de Lisboa, Portugal.
Round table
 Universidade e trabalho científico
2018/06/21 - 2018/06/23 Poster communication - Bento-Oliveira A, Pereira P, de Almeida RF, Amaro-Leal A Cunha-Reis, D (2018). Altered synaptic plasticity and lipid raft composition in a rat model of MTLE.
Workshop
 Workshop on Integrative Approaches in Neurodegeneration
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/06/21 - 2018/06/23 Poster communication - Nascimento C, Pereira P, Tavares C, Gonçalves-Rosa N Esteves-Coelho J, Cunha-Reis, D (2018). Impaired response to novelty and motor behaviour in a rat model of accelerated aging.
Workshop
 Workshop on Integrative Approaches in Neurodegeneration
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/06/21 - 2018/06/23 Poster communication - Bento-Oliveira A, Pereira P, de Almeida RF, Amaro-Leal A Cunha-Reis, D (2018). Altered synaptic plasticity and lipid raft composition in a rat model of MTLE. Communication to the Workshop on Integrative Approaches in Neurodegeneration, FCUL, Lisboa, Portugal, 21st -23rd June 2018.
Workshop
 Workshop on Integrative Approaches in Neurodegeneration
Universidade de Lisboa Faculdade de Ciências, Portugal
2018/02/05 - 2018/02/07 Oral Communication - Bento-Oliveira A, Rodrigues NC, Ribeiro JA, de Almeida RF, Cunha-Reis, D (2018). Changes in AMPA receptors GluA1 subunit and Kv4.2 phosphorylation in rat hippocampus.
Meeting
 48th REUNION OF THE PORTUGUESE PHARMACOLOGICAL SOCIETY

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12/03 Changes in synaptic plasticity, lipid raft composition in the hippocampus in different ages and gender, induced in vitro by epileptiform activity and neuroprotective role of VPAC1 VIP receptor antagonists
Supervisor
 José Diogo Carvalho Rosa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2021/09/10 Effect of cannabidiol on synchronous GABA and glutamate release from resting hippocampal nerve terminals
(Thesis) Main arguer
 Laura Pereira Marinho (Other)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/11/22 THE EFFECT OF CANNABIDIOL IN THE IMMATURE BRAIN
(Thesis) Main arguer
 Ana Veiga Caulino Rocha (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/01 Changes in synaptic plasticity and lipid raft composition in a rat model of temporal lobe epilepsy
Supervisor
 Andreia Bento de Oliveira (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/09/09 - 2024/10/01 Neural Regeneration Research (1673-5374) Lippincott / Wolters Kluwer
2024/06/03 - 2024/06/20 Exploration of Neuroprotective Therapy (2769-6510) Open Exploration
2024/05/23 - 2024/05/29 Neural Regeneration Research (1673-5374) Lippincott / Wolters Kluwer
2024/05/13 - 2024/05/21 Neurochemical Research (0364-3190) Springer Nature
2023 - 2023 Neuroscience Letters Elsevier
2023 - 2023 Frontiers in Cellular Neuroscience Frontiers Media
2022/09 - 2022/09 Neural Regeneration Research (1876-7958) Wolters Kluwer
2022/09 - 2022/09 Frontiers in Neural Circuits (1970-5565) Frontiers Media S.A.
2022/07 - 2022/08 International Journal of Molecular Sciences ( 1422-0067) MDPI
2022/05 - 2022/05 International Journal of Molecular Sciences ( 1422-0067) MDPI
2022/04 - 2022/05 Biomedicines (2227-9059) MDPI
2022/01/24 - 2022/02/07 International Journal of Environmental Research and Public Health MDPI
2021 - 2021 International Journal of Molecular Sciences MDPI
2021 - 2021 Journal of Inflammation Research Dove Press
2020 - 2020 Biology (2079-7737) MDPI
2020 - 2020 Biology MDPI
2019 - 2019 Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media
2019 - 2019 Frontiers in Cellular Neuroscience Frontiers
2018/01 - 2018/09 Experimental Gerontology (0531-5565) Elsevier
2013 - 2013 Journal of Zhejiang University SCIENCE B (1862-1783) Zhejiang University Press

Conference scientific committee

Conference name Conference host
2023/11 - 2024/11/07 3rd International Meeting of the Portuguese Society of Physiology (Physioma 2024) Faculdade de Medicina da Universidade do Porto
2023/11 - 2024/09/06 XXIII Meeting of the Federation of European Physiological Societies (FEPS) & XLI Meeting of the Spanish Society for Physiological Sciences Spanish Society for Physiological Sciences
2022/05 - 2022/11/18 2nd International Congress of the Portuguese Society of Physiology Sociedade Portuguesa de Fisiologia
2003/12/01 - 2014/01/31 FENS Forum 2014 Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02/01 - 2024/07/09 Supervisor of 2 research projects under the course Laboratory in Molecular Biology and Genetics, 1st year Master Program in Molecular Biology and Genetics MSc, DBV, Ciências, ULisboa (https://fenix.ciencias.ulisboa.pt/courses/lbmg-2536354281947729/pagina-inicial). Master in Molecular Biology and Genetics (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/13 - 2024/02/18 Cell biology lecturer and lab teaching assistant in Complements in Cell Biology (UC 62806), 3rd year Biology BSc, DBV, Ciências, ULisboa (https://fenix.ciencias.ulisboa.pt/courses/bccom-2536354281947915). Biologia (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2023/09/13 - 2024/02/17 Supervisor / lab teaching assistant of research project under the course Oriented studies in Molecular Biology and Genetics (UC 62841), 3rd year Biology BSc, DBV, Ciências, ULisboa (https://fenix.ciencias.ulisboa.pt/courses/eobmg-1973404328526652/pagina-inicial). Biologia (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/01 - 2021/07/31 Physiology lecturer and course responsible, Biochemistry BSc FCUL by invitation. Biochemistry (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/09/01 - 2014/07/31 Human Physiology course responsible (Pharmaceutical Sciences Integrated MSc) Mestrado Integrado em Ciências Farmacêuticas (Mestrado) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2012/09/01 - 2014/07/31 Physiology Course responsible (Nutrition BSc degree) Nutrição (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias Escola de Ciências e Tecnologias da Saúde, Portugal
2012 - 2014 Human Physiology I (Pharmacological Sciences integrated MSc) Fisiologia Humana I (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2014 Physiology I (Nutrition degree) Fisiologia I (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2013 Human Physiology II Fisiologia humana II (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2012 - 2013 Physiology II (Nutrition degree) Fisiologia II (Mestrado integrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2024/10/05 - Current Evaluator of the proposals submitted to the 2024 call of the of the Marie Sklodowska Curie Actions Postdoctoral Fellowships Horizon Europe MSCA PF 2024
Evaluator
 European Commission, Belgium Horizon 2020
2024/10/01 - 2024/10/15 Scientific evaluator of the abstracts submitted to the 3rd International Conference of the Portuguese Physiology Society
Evaluator
 Sociedade Portuguesa de Fisiologia, Portugal Sociedade Portuguesa de Fisiologia
2024/05 - 2024/06 Evaluator of six proposals submitted to the 2024 call for Fellowships for excellent researchers R2-R4, Recovery and Resilience Plan of the Slovak Republic, Component 9, Research Agency (Výskumná agentúra) and VAIA, Slovak Republic.
Evaluator
 Agentúra na podporu výskumu a vývoja Slovenskej republiky, Slovakia Agentúra na podporu výskumu a vývoja Slovenskej republiky
2023/10 - 2023/12 Evaluator of the proposals submitted to the 2023 call of the of the Marie Sklodowska Curie Actions Postdoctoral Fellowships H2022 MSCA PF 2023
Evaluator
 Research Executive Agency, Belgium Horizon 2020
2022/10/07 - 2022/11/22 Evaluator of the proposals submitted to the 2022 call of the of the Marie Sklodowska Curie Actions Postdoctoral Fellowships H2022 MSCA PF 2022.
Evaluator
 European Commission, Belgium EU Framework Programme for Research and Innovation Excellent Science
2022/10/04 - 2022/10/10 Scientific evaluator of the abstracts submitted to the 2nd International Conference of the Portuguese Physiology Society
Evaluator
 Sociedade Portuguesa de Fisiologia, Portugal
2021/11/01 - 2021/12/21 Evaluator of the proposals submitted to the 2021 call of the of the Marie Sklodowska Curie Actions Postdoctoral Fellowships H2021 MSCA PF 2021.
Evaluator
 European Commission, Belgium EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2020/10/02 - 2020/12/04 Evaluation of the proposals submitted to the Marie Sklodowska-Curie Individual Fellowships H2020-MSCA-IF-2020
Evaluator
 Research Executive Agency, Belgium European Commission
2019/10/01 - 2019/12/05 Evaluator of the proposals submitted to the Marie Sklodowska-Curie Individual Fellowships H2020-MSCA-IF-2019
Evaluator
 Research Executive Agency, Belgium European Commission

Interview (tv / radio show)

Program Topic
2008/03/18 - Current TV Ciência - Neurociências Comunicação entre neurónios pode ser chave do segredo de algumas doenças

Journal scientific committee

Journal title (ISSN) Publisher
2024/10/30 - Current Neuroscience Insights (2633-1055) Sage Journals
2024/07 - Current Neuromarkers (2950-5887) Elsevier
2024/02 - Current Exploration of Neuroprotective Therapy (2769-6510) Open Exploration
2022/11/10 - Current Frontiers in Cellular Neuroscience Frontiers Media S.A.
2022/09/05 - Current Editor of special issue in Biomedicines - Drugs Targeting the Disease Progression, Cognitive Impairment, Anxiety and Other Co-Morbidities in Epilepsy: From Bench to Bedside (2227-9059) MDPI
2021/07 - 2023/06/30 Frontiers in Cellular Neuroscience Special issue: Cellular and Molecular Targets In Epileptogenesis Focusing on Disease Prevention Frontiers

Mentoring / Tutoring

Topic Student name
2024/03/01 - Current Altered phosphorylation of hippocampal ionotropic glutamate receptors and CaMKII upon ageing: implications for synaptic plasticity and cognitive decline Daniela Fernandes, 1st year MSc student in Biochemistry and Biomedicine
2023/09/01 - 2024/05/31 Altered phosphorylation of hippocampal ionotropic glutamate receptors along post-weaning development Vasco Guerrero Pinto
2021/11/01 - 2023/06/30 Expression of VIP and VIP receptors during postweaning development and in epilepsy Marta Berardo Pina Santos Bento
2021/03/01 - 2021/09/30 Changes in lipid peroxidation and lipid raft composition in a rat model of temporal lobe epilepsy - Seweryn Pawlak
2021/03/01 - 2021/09/30 Synaptic proteins, VIP receptors and synaptic plasticity in the hippocampus: influence of age and developmental influence - Marta Gil
2020/09/01 - 2021/06/30 Synaptic proteins, synaptic plasticity and monoaminergic inputs to the hippocampus: influence of mismatch novelty training - Ana Carolina Duque Queiroz
2018/09/01 - 2019/10/31 Cell culture models of the blood-brain barrier for drug delivery studies to the CNS Diana Georgete Silva Monteiro Dos Reis Borges
2018/09/01 - 2019/09/30 Cell culture models to study in vitro epileptiform activity Beatriz Pereira e Vila-Verde da Costa e Silva
2014/05/01 - 2015/09/30 Involvement of Kv4.2 channels in endogenous VIP modulation of LTP in the hippocampus Stivon Silva
2009/07/01 - 2009/07/31 Modulation of hippocampal LTP by VIP receptors Suzanne Gotham
2009/02/01 - 2009/05/31 VPAC1 receptors in a rat model of MTLE Ewa Tauroginska Tokarczyk
Distinctions

Award

2009 Invited speaker congress grant for participation in the meeting ‘9th International Symposium on VIP, PACAP and related peptides’, October 5th-8th 2009, Kagoshima, Japan.
VIP-PACAP 2009 Congress Organizers, Japan
2007 Bolsa para participação em Summer School Advanced Course in Neuroplasticity
Fundação Calouste Gulbenkian, Portugal
2005 Bolsa participação em congresso VIP-PACAP2005
Fundação Calouste Gulbenkian, Portugal
2004 Bolsa participação em congresso FENS2004
Sociedade Portuguesa de Neurociências, Portugal
2002 Bolsa participação em congresso FENS2002
Sociedade Portuguesa de Neurociências, Portugal
1998 Young Investigator Congress Fellowship

Other distinction

2021 Invited speaker and seminar coordinator at the 56th Congress of SBFis (Brazilian Society of Physiology)
Sociedade Brasileira de Fisiologia, Brazil
2020 Invited speaker at the 55th Annual Congress of SBFIS October 2020
Sociedade Portuguesa de Fisiologia, Portugal
2006 Bolsa participação em congresso FENS2006
Sociedade Portuguesa de Neurociências, Portugal