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Carolina Emanuel Carreira Gomes Jardim concluded the MsC in Biochemistry with specialization in Medical Biochemistry on 2012/11/09 by the Faculdade de Ciências da Universidade de Lisboa and concluded the BsC in Biotechnology Engineering on 2010/02/11 by the Universidade Lusófona de Humanidades e Tecnologias. Carolina Jardim published 10 peer-review papers and have 5 oral presentations, 5 posters as first author and over 6 posters as co-author. Organized 2 events and Co-supervised the work of 3 master students. Received 1 award (travel grant) to present the developed scientific work. During her work as researcher she concluded over 10 courses and gain expertise on: Ageing and neurodegeneration; Molecular mechanisms of oxidative stress; Molecular and cellular biology; Cellular models of Parkison´s, Alzheimer´s, ALS, Huntington´s and Cancer; Manipulation of Saccharomyces cerevisiae and cell lines and Polyphenols from berries isolation and screening as bioactive compounds. Carolina Jardim is a PhD student at Faculdade de Medicina, Universidade de Lisboa, developing her work in Biomedical science with specialization in Immunology. The current scientific interests are: Interplay between tumour and immune cells in disease progression; Molecular mechanisms underlying the Pro-tumoural and Anti-tumoural effect of Myeloid cells in the tumour; Myeloid cells anti-tumour effect in metastasis; T cells differentiation and tumor development; Cancer Immunotherapy; GamaDelta T cells differentiation, disease progression (inflammation, neurodegenerative diseases, infection and cancer) and immunotherapy potential; Clonal evolution of Cancer and Chemotherapy resistance; Relapse mechanisms in Acute Myeloid Leukemia (AML) and Hypomethylating agents in AML for relapse prevention.
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Identification

Personal identification

Full name
Carolina Emanuel Carreira Gomes Jardim

Citation names

  • Jardim, Carolina

Author identifiers

Ciência ID
2115-AAB3-4424
ORCID iD
0000-0001-6929-6469
Google Scholar ID
https://scholar.google.com/citations?user=PWfEE0QAAAAJ&hl=pt-BR&oi=sra

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Upper intermediate (B2)
Spanish; Castilian Elementary (A2) Intermediate (B1) Elementary (A2) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2019
Ongoing
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Imunologia
Universidade de Lisboa Faculdade de Medicina, Portugal
"Monocytes/macrophages as allies against cancer how to instruct them to prevent primary tumour growth and metastasis formation?" (THESIS/DISSERTATION)
2010/09/01 - 2012/11/09
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica Médica
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
"Research of polyphenols with neuroprotective potential in a yeast model of degeneration " (THESIS/DISSERTATION)
 17
2006/09/01 - 2010/02/11
Concluded
 Engenharia Biotecnológica (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2017/02/15 - 2019/11/30 Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/05/01 - 2016/10/01 Researcher (Research) Instituto de Biologia Experimental e Tecnológica, Portugal
Instituto de Biologia Experimental e Tecnológica, Portugal
2013/01/01 - 2014/04/01 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projects

Grant

Designation Funders
2019/12 - 2024/10 Monocytes/macrophages as allies against cancer: how to instruct them to prevent primary tumour growth and metastasis formation
74699DFA
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/12/01 - 2023/12/30 Programming anti-tumour myeloid cells to improve cancer immunotherapies
02/SAICT/2017-030948
PhD Student Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/02/15 - 2019/11/30 PRECISE “Promoção do avanço significativo do conhecimento na área de medicina de precisão e sua translação para benefício da sociedade”
016394
Research Fellow
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2014/05/01 - 2016/10/01 BacHBerry – BACterial Hosts for production of Bioactive phenolics from bERRY fruits
FP7-KBBE- 2013-613793
Research Fellow
Instituto de Biologia Experimental e Tecnológica, Portugal
 European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2011/02/01 - 2014/04/30 Polifenóis como agentes protectores em modelos celulares de alfa-sinucleinopatias, em particular na doença de Parkinson
PTDC/BIA-BCM/111617/2009
Research Fellow
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Jardim, Carolina. "Sustained macrophage reprogramming is required for long-term tumour resolution". Paper presented in XLIX Annual SPI Meeting, 2024.
  2. Jardim, Carolina. "Combined TLR3 and CD40 signalling triggers macrophage-dependent antitumour immunity". Paper presented in 13th EMBO Young Scientists’ Forum, 2023.
  3. Jardim, Carolina. "Functional determinants of anti-tumoural macrophages in the tumour microenvironment". Paper presented in XV CAML. V NeurULisboa PhD Students CAML, 2022.
  4. Jardim, Carolina. "Functional determinants of anti-tumoural macrophages in the TME". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  5. Jardim, Carolina. "Monocytes/macrophages as allies against cancer: how to instruct them to prevent primary tumour growth and metastasis formation?". Paper presented in XLVI Annual SPI Meeting, 2021.
  6. Jardim, Carolina. "Monocytes/macrophages as allies against cancer: how to instruct them to prevent primary tumour growth and metastasis formation?". Paper presented in XIV CAML. IV NeuroULisboa PhD Students Virtual Meeting, 2021.
  7. Jardim, Carolina. "Novos polifenóis com potencial terapêutico revelados através da bioprospeção da biodiversidade dos pequenos frutos". Paper presented in V Colóquio Nacional de de Produção de Pequenos Frutos, 2016.
  8. Jardim, Carolina. "Raspberry as source of new anti-huntington compounds: bio-guided assay using humanized yeast". Paper presented in XXVIIIth ICP - International conference on polyphenols, 2016.
  9. Jardim, Carolina. "New perspectives on bioactivity of olive oil: from cell model to human intervention". Paper presented in Vitafoods, 2016.
  10. Jardim, Carolina. "Digested (poly)phenols from Arbutus unedo confer cytoprotection against oxidative stress in Saccharomyces cerevisiae". Paper presented in 7th ICPH - International Conference of Polyphenols and Health, 2015.
  11. Jardim, Carolina. "Bioprospection of a berry germplasm for the identification of novel therapeutic (poly)phenols using a humanized yeast platform". Paper presented in 7th ICPH - International Conference of Polyphenols and Health, 2015.
  12. Jardim, Carolina. "Yeast as a model to study pyrolysis products of synthetic cannabinoids". Paper presented in 3nd International Meeting in Forensic Sciences and Criminal Behaviour, 2015.
  13. Jardim, Carolina. "Yeast SMART platforms: screening of berry bioactive phenolics with protective function towards human degenerative diseases". Paper presented in 1st European Summer School on Nutrigenomics, 2014.
  14. Jardim, Carolina. "Protective effects conferred by A. unedo digested polyphenols against oxidative injury in Saccharomyces cerevisiae oxidative stress model". Paper presented in XX Jornadas de Leveduras Professor Nicolau Van Uden, 2014.
  15. Jardim, Carolina. "Protective effects conferred by A. unedo digested polyphenols against oxidative injury in Saccharomyces cerevisiae oxidative stress model". 2014.
  16. Jardim, Carolina. "Yeast as a model to study synthetic cannabinoids". Paper presented in 2nd International Meeting in Forensic Sciences and Criminal Behaviour, 2014.
  17. Jardim, Carolina. "Disclosing the mechanisms behind the protective effect of A. unedo fruit metabolites against oxidative injury in yeast". Paper presented in 4th Management Committee & Working Groups Meeting of COST Action FA 100, 2013.
  18. Jardim, Carolina. "Berries Polyphenols: A multiapproach to disclose human health benefits". Paper presented in IUNS-20th International Congress of Nutrition, 2013.
  19. Jardim, Carolina. "Potential of berries polyphenols for preventing age-related neurodegeneration". Paper presented in 7th International Workshop on Anthocyanins, 2013.
  20. Jardim, Carolina. "Framboesa e medronho: potenciais fontes de compostos bioactivos para a doença de Parkinson". Paper presented in IV colóquio nacional da produção de pequenos frutos, 2012.
Journal article
  1. Mariana Reis-Sobreiro; Afonso Teixeira da Mota; Carolina Jardim; Karine Serre. "Bringing Macrophages to the Frontline against Cancer: Current Immunotherapies Targeting Macrophages". Cells 10 9 (2021): 2364-2364. https://doi.org/10.3390/cells10092364.
    10.3390/cells10092364
  2. Caiado, Francisco; Maia-Silva, Diogo; Jardim, Carolina; Schmolka, Nina; Carvalho, Tânia; Reforço, Cláudia; Faria, Rita; et al. "Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-12983-z.
    10.1038/s41467-019-12983-z
  3. Ferreira, Carla; Couceiro, Joana; Família, Carlos; Jardim, Carolina; Antas, Pedro; Santos, Cláudia N; Outeiro, Tiago F; Tenreiro, Sandra; Quintas, Alexandre. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research 19 5 (2019): http://dx.doi.org/10.1093/femsyr/foz042.
    10.1093/femsyr/foz042
  4. Kallscheuer, Nicolai; Menezes, Regina; Foito, Alexandre; da Silva, Marcelo Henriques; Braga, Adelaide; Dekker, Wijbrand; Sevillano, David Méndez; et al. "Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington’s Disease". Plant Physiology 179 3 (2018): 969-985. http://dx.doi.org/10.1104/pp.18.01074.
    10.1104/pp.18.01074
  5. Rosado-Ramos, Rita; Godinho-Pereira, Joana; Figueira, Ines; Jardim, Carolina; Garcia, Goncalo; Menezes, Regina. "Exploring the Benefits of Cellular Models to Uncover Bioactive Polyphenols for Neurodegeneration". Current Pharmaceutical Design 24 19 (2018): 2076-2106. http://dx.doi.org/10.2174/1381612824666180629112148.
    10.2174/1381612824666180629112148
  6. Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". (2018): http://www.scopus.com/inward/record.url?scp=85046675039&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-25118-z
  7. Figueira, Inês; Tavares, Lucélia; Jardim, Carolina; Costa, Inês; Terrasso, Ana P.; Almeida, Andreia F.; Govers, Coen; et al. "Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study". European Journal of Nutrition 58 1 (2017): 113-130. http://dx.doi.org/10.1007/s00394-017-1576-y.
    10.1007/s00394-017-1576-y
  8. Dudnik, Alexey; Almeida, A. Filipa; Andrade, Ricardo; Avila, Barbara; Bañados, Pilar; Barbay, Diane; Bassard, Jean-Etienne; et al. "BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits". Phytochemistry Reviews 17 2 (2017): 291-326. http://dx.doi.org/10.1007/s11101-017-9532-2.
    10.1007/s11101-017-9532-2
  9. Jardim, Carolina; Macedo, Diana; Figueira, Inês; Dobson, Gary; McDougall, Gordon J.; Stewart, Derek; Ferreira, Ricardo B.; et al. "(Poly)phenol metabolites from Arbutus unedo leaves protect yeast from oxidative injury by activation of antioxidant and protein clearance pathways". Journal of Functional Foods 32 (2017): 333-346. http://dx.doi.org/10.1016/j.jff.2017.03.010.
    10.1016/j.jff.2017.03.010
  10. Jardim, Carolina. "European Summer School on Nutrigenomics. September 1¿5, 2014 Camerino, Italy: Abstracts". Journal of Nutrigenetics and Nutrigenomics 7 2 (2014): 75-93. http://dx.doi.org/10.1159/000365938.
    10.1159/000365938
Thesis / Dissertation
  1. Jardim, Carolina Emanuel Carreira Gomes. "Research of polyphenols with neuroprotective potential in a yeast model of degeneration". Master, 2012. http://hdl.handle.net/10451/9456.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/10/15 Sustained macrophage reprogramming is required for CD8 T cell-dependent long-term tumor resolution PhD Students Retreate NMS
Nova Medical School (Lisboa, Portugal)
2024/05/14 Sustained macrophage reprogramming is required for long-term tumour resolution XVII PhD Students Meeting from CAML
GiMM (Lisboa, Portugal)
2024/04/16 Sustained macrophage reprogramming is required for long-term tumour resolution 5th Symposium on Immunomodulation in Cancer and Regeneration
SPI (Lisboa, Portugal)
2023/05/11 Combined TLR3 and CD40 signalling triggers macrophage-dependent antitumour immunity XVI PhD Students Meeting from CAML
GiMM (Lisboa, Portugal)
2023/03/30 Combined TLR3 and CD40 signalling triggers macrophage-dependent antitumour immunity XLVIII Annual SPI Meeting
SPI (Lisboa, Portugal)
2022/11/15 Macrophages as allies against cancer: how to instruct them to prevent primary tumour growth 6ª Conferência Anual da rede SAÚDE da Universidade de Lisboa “Perspetivas Multidisciplinares e Saúde Global na ULisboa
Universidade de Lisboa (Lisboa, Portugal)
2022/02/18 Molecular determinants of myeloid cells with protective Anti-Tumoural functions in the TME Cost Action Mye-InfoBank - young researcher workshop
Cost Action Mye-InfoBank (Lisboa, Portugal)
2016/10/14 A framboesa como fonte de novos compostos anti-Huntington V Colóquio Nacional de de Produção de Pequenos Frutos
INIAV (Oeiras, Portugal)
2016/09/15 Bioprospection of novel therapeutic (poly)phenols from a large soft fruit germplasm collection 1st International conference of Food Bioactives and Health
(Norwich, United Kingdom)
2016/06/11 Novel therapeutic (poly)phenols revealed after berry germplasm bioprospection XXVIIIth International Conference on Polyphenols
(Viena)
2014/06/06 Daily Polyphenols intake from fresh fruits in Portugal. Berries: Effects of metabolites on brain 8th ISANH Congress on Polyphenols Applications
(Lisboa, Portugal)
2014/05/08 BACterial Hosts for production of Bioactive phenolics from bERRY fruits 2sd consortium meeting
The James Hutton Institute - EU (Lisboa, Portugal)
2014/05/07 BACterial Hosts for production of Bioactive phenolics from bERRY fruits 2sd consortium meeting
idMEC- Instituto de Engenharia Mecânica / IST (Lisboa, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/02/01 - 2020/06/30 Elucidar a diversidade fenotípica e funcional das células mielóides em circulação no sangue de doentes de cancro da mama em neoadjuvância
Co-supervisor
 Oncologia Clínica (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2016/09/01 - 2016/12/31 Unraveling phenolics with potential therapeutic application for neurodegeneration
Co-supervisor
 Biochemistry for Heatlh (Master)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/03/01 - 2015/12/01 Protective activity of phytochemicals from natural extracts
Co-supervisor
 Biochemistry for Heatlh (Master)
Universidade Nova de Lisboa, Portugal
2013/09/01 - 2014/11/01 Polyphenols neuroprotective effect in a Parkinson´s disease yeast model: phosphoproteome alterations
Co-supervisor
 Biomedical Sciences (Master)
Universidade do Algarve, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/06/01 - 2016/10/25 Member of the organization committee of the “V Colóquio Nacional de Produção de Pequenos Frutos” (2016/10/14 - 2016/10/15)
Conference (Member of the Organising Committee)
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2015/01/02 - 2015/03/06 Member of the organization committee of the Euberry conference: A INVESTIGAÇÃO NO ÂMBITO DO PROJETO EUBERRY (2015/03/06 - 2015/03/06)
Conference (Member of the Organising Committee)
 Instituto de Biologia Experimental e Tecnológica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/10/18 - 2024/10/18 1st IMMUNO-ONCOLOGY SPO-SPI SCHOOL
Workshop
 1st IMMUNO-ONCOLOGY SPO-SPI SCHOOL
Sociedade Portuguesa de Imunologia, Portugal
2024/06/04 - 2024/06/04 Workshop on Statistics – “Easy Statistics to Shine in Biological Research” - iMM-JLA
Workshop
 Workshop on Statistics – “Easy Statistics to Shine in Biological Research”
Universidade de Lisboa, Portugal
2024/05/14 - 2024/05/14 Workshop on Clinical trials by André Mansinho -, XVII PhD Students Meeting from CAML, Lisbon School of Medicine (iMM-JLA)
Workshop
 Workshop on Clinical trials
Universidade de Lisboa, Portugal
2020/03/02 - 2020/03/04 EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
Conference
 EACR-AACR Basic and Translational Research Conference in partnership with ASPIC: Tumor Microevironment
European Association For Cancer Research, United Kingdom
2019/09/26 - 2019/12/12 Scientific Writing Course
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019/03/27 - 2019/03/29 5th workshop on dendritic cell biology: anti-tumoral immunotherapy, from biology to the clinic
Workshop
 5th workshop on dendritic cell biology: anti-tumoral immunotherapy, from biology to the clinic
Fundação Champalimaud, Portugal
2018/06/27 - 2018/06/29 XLIV Annual Meeting of the Portuguese Society for Immunology
Conference
 XLIV Annual Meeting of the Portuguese Society for Immunology
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/05/29 - 2017/05/31 ReTuBi Summer School: from cancer biology to therapy?
Workshop
 ReTuBi Summer School: from cancer biology to therapy?
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2017/03/27 - 2017/04/10 Laboratory Animal Science course according to FELASA cat. B
Workshop
 Laboratory Animal Science course according to FELASA cat. B
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016/09/01 - 2017/02/01 Lessons of Histology under the Medical degree curriculum
Workshop
 Lessons of Histology
Universidade de Lisboa Faculdade de Medicina, Portugal
2014/09/01 - 2014/09/05 1st Summer School on Nutrigenomics
Conference
 1st European Summer School on Nutrigenomics
Università degli Studi di Camerino, Italy
2013/12/03 - 2013/12/07 Bioestatistical Training course in “Foundations on Bioinformatics Course using R”
Workshop
 Bioestatistical Training course in “Foundations on Bioinformatics Course using R”
Instituto Gulbenkian de Ciência, Portugal
2013/06/17 - 2013/06/21 Flow cytometry course under CAML curriculum
Workshop
 Flow cytometry course
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/12/01 - 2024/11/09 COST Action CA20117: Converting Molecular Profiles of Myeloid Cells into Biomarkers for Inflammation and Cancer (Mye-InfoBank)
Member
2013/01/01 - 2016/10/31 Early Stage Researcher participating in COST Action FA1005 - Improving health properties of food by sharing our knowledge on the digestive process (INFOGEST)
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016/04/18 - 2016/04/18 Principles and applicability of Polymerase Chain Reaction(2h); Class of Applied Nutrition; Master in Alimentary Technology, Escola Superior Agrária de Santarém mestrado em tecnologia alimentar (Mestrado) Instituto de Biologia Experimental e Tecnológica, Portugal

Scientific expedition

Activity description Institution / Organization
2008/06/06 - 2008/06/15 “Lusoexpedição - O Banco de Gorringe, a Madeira e o percurso das espécies marinhas no atlântico norte” Universidade Lusófona de Humanidades e Tecnologias, Portugal
Distinctions

Award

2022 Best PhD work in Oncology and precision medicine
Universidade de Lisboa, Portugal
2014 Travel Grant
Università degli Studi di Camerino, Italy