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L. Matos graduated in Biochemistry from the Faculty of Sciences, University of Porto in 2005. She then moved to the Faculty of Medicine, University of Porto, where she pursued her post-graduate studies: she obtained her MSc in Molecular Medicine and Oncology in October 2008 and her PhD degree in Metabolism, clinical and experimental in December 2015. At the same time, since October 2006, she lectures Cellular and Molecular Biology (CMB) at the Faculty of Nutrition and Food Sciences, University of Porto (UP), where she assumed regency since Sep 2020. From October 2016 until September 2020 she also lectured and took on the regency of 2 curricular units of CMB at the Faculty of Dental Medicine, UP. Her PhD thesis on ¿Metal-induced oxidative stress in human fibroblasts: a role in cellular ageing¿, describes a novel stress-induced premature senescence cellular model, demonstrates for the first time the requirement of unfolded protein response activation for the induction of senescence in non-tumoral cells and reports resveratrol protective effects on senescence. These major findings were published as three original research papers in Q1 journals in the field, in which she was the first author. After finishing her PhD, she went twice on maternity leave, which caused 2 interruptions in her scientific/academic activities. As a specialist in the field of cellular ageing, L. Matos is annually invited to lecture in Gerontology sessions of MSc and PhD programs at FMUP. Also, the expertise obtained during her MSc on molecular human reproduction allowed her to participate in national and internationally funded projects (Crioestaminal, Bebévida and Merck¿s Grant for Fertility Innovation) and maintain active collaborations in this research field that resulted in co-authorship of 5 publications: in 2017, a review paper on the involvement of follicular fluid redox state on ovarian follicle growth and an original research paper on age-related expression of TGF beta receptors in human cumulus oophorus cells (doi:10.1007/s10815-017-0930-6); in 2019, an original research paper on the appearance/modulation of age-related changes in mouse ovaries (doi:10.1155/2019/5316984); in 2020, an original research paper on the impact of age-related oxidative modifications to uterine albumin in trophoblasts function (doi:10.1016/j.freeradbiomed.2020.03.020); and in 2021 a review paper on the redox imbalance in age-related ovarian dysfunction. Overall, she published 21 papers in international peer reviewed journals and 1 book chapter (with 2 authors), accumulating 392 citations, with an h-index of 11. L. Matos received several national and international distinctions, including a COST supported travel grant and best poster/communication awards. Besides, she participates in dissemination of knowledge activities promoted by "Escola de Ciências da Vida e da Saúde" since 2007, has experience in mentoring pre-/post-graduate students to acquire autonomy in several routine/specific lab procedures, and she started the formal supervision of BSc students: five concluded between 2020 and 2023 and one ongoing, to be finished in 2024. Currently, L. Matos actively collaborates with clinicians (Hospital CUF Porto, CETI, and Centro Materno-Infantil do Norte), having facilitated access to human samples, which allows her to be enrolled in translational research. In the 4th edition of individual CEEC promoted by FCT, she has been awarded with a 6-years junior researcher contract (https://doi.org/10.54499/2021.02032.CEECIND/CP1663/CT0013). Also, she had an approved project as principal investigator in 2022 FCT call (http://doi.org/10.54499/2022.04368.PTDC).
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Identification

Personal identification

Full name
Liliana Raquel Casais de Matos Silva

Citation names

  • Matos, Liliana

Author identifiers

Ciência ID
2119-14D1-79EB
ORCID iD
0000-0003-4188-532X
Researcher Id
H-5515-2013
Scopus Author Id
25223373700

Email addresses

  • lmatos@fcna.up.pt (Professional)

Addresses

  • Instituto de Investigação e Inovação em Saúde, Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Clinical Medicine - Geriatrics and Gerontology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2015/12/21
Concluded
 Metabolismo - Clínica e Experimentação (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Metal-induced oxidative stress in human fibroblasts: a role in cellular ageing." (THESIS/DISSERTATION)
 Aprovado com distinção
2005/10/01 - 2008/10/08
Concluded
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Dismutases do anião Superóxido nas células do cumulus oophorus humanas." (THESIS/DISSERTATION)
 Muito Bom, por unanimidade
2005/05
Concluded
 Laboratory Animal Science Course (according to FELASA-Cat C), at IBMC- UP (Accreditation as a researcher/coordinator to practice animal experimentation by "Direcção Geral de Veterinária" since June 2008) (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2005/01/25
Concluded
 Bioquímica (Licenciatura)
Major in Bioquímica Aplicada
Universidade do Porto Faculdade de Ciências, Portugal
"O córtex Supra-Renal no stress oxidativo" (THESIS/DISSERTATION)
 13 valores
Affiliation

Science

Category
Host institution 		Employer
2022/09/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/12/22 - 2022/08/31 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2007/04/01 - 2007/06/01 Research Trainee (Research) Facultes Universitaires Notre-Dame de la Paix Unité de recherche en biologie moléculaire, Belgium
2005/01/25 - 2006/04/01 Research Trainee (Research) Universidade do Porto Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2016/10/01 - 2020/08/31 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina Dentária, Portugal
2019/04/01 - 2019/06/30 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2017/09/01 - 2018/02/28 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2016/09/01 - 2017/02/28 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2009/09/01 - 2016/08/31 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2006/10/01 - 2009/09/01 Tutor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal

Others

Category
Host institution 		Employer
2014/07/24 - Current External professor for Biogerontology, Gerontology I and Gerontology II (1 or 2 lectures/year in each pre- or post-graduation curricular unit) Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2015 PhD student Universidade do Porto Faculdade de Medicina, Portugal
2005/10/01 - 2008/10/08 MSc student Universidade do Porto Faculdade de Medicina, Portugal
2006/04/01 - 2006/08/01 Research grant (supported by Sociedade Portuguesa de Ginecologia) Universidade do Porto Faculdade de Medicina, Portugal
2003/10/01 - 2005/01/25 Research Trainee (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2011 - 2014 Utilization of biomarkers in human cumulus oophorus cells to improve oocyte selection and ART outcome.
GFI 2011
Team member
Concluded
2009/10 - 2013/09 Metal-induced oxidative stress in human fibroblasts: a role in cellular ageing
SFRH/BD/61820/2009
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2006/04/01 - 2006/08/01 Efeito modulador da hormona foliculo-estimulante (FSH) na activação de mecanismos antioxidantes no cumulus oophorus
SPG_grant
Scientific Initiation Fellow
Sociedade Portuguesa de Ginecologia
Concluded

Contract

Designation Funders
2022/08/16 - 2028/08/15 Targeting uterine senescent cells: an approach to improve fertility at advanced maternal age
2021.02032.CEECIND/CP1663/CT0013
10.54499/2021.02032.CEECIND/CP1663/CT0013
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/01 - 2024/08/31 Keep fertility at advanced maternal age: on the track of uterine senescent cells
2022.04368.PTDC
10.54499/2022.04368.PTDC
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2014 - 2014 Alterações oxidativas no sangue materno na gravidez normal, associada a ameaça e a parto pré-termo
Bebévida
Team member
Bebévida
2011 - 2012 Redox balance in placental bed as modulator of older women pregnancies
crioestaminal2011
Other
Crioestaminal
Concluded
2011 - 2011 Aged female diet anti-oxidant supplementation: effect on placental bed and reproductive outcome
PP_IJUP_2011_86
Other
IJUP – Investigação Jovem da Universidade do Porto
Concluded
2009 - 2010 Effect of resveratrol in stress-induced premature senescent human fibroblasts
UP_SantanderTotta
PhD Student Fellow
Universidade do Porto and Santander Totta
Concluded
2007 - 2008 Efeito modulador da hormona foliculo-estimulante (FSH) na activação de mecanismos antioxidantes no cumulus oophorus
SPG2007
Master Student Fellow
Sociedade Portuguesa de Ginecologia
Outputs

Publications

Book chapter
  1. Almeida, H.; Matos, Liliana. "Human ageing, a biological view.". In Anti-Ageing Nutrition: Evidence-Based Prevention of Age-Associated Diseases., edited by Delminda Neves, 3-31. UK: Wiley Blackwell., 2015.
    Published • 10.1002/9781118823408.ch1
Conference abstract
  1. Matos, Liliana; Stevenson, D.; Florbela Gomes; Silva-Carvalho, J.L.; Henrique Almeida. "Dismútase do superóxido manganês em células do cumulus oophorus humanas". Paper presented in 3º Congresso Nacional da Sociedade Portuguesa de Medicina da Reprodução, 2007.
    Published
Conference paper
  1. Sara Mendes; Timóteo-Ferreira F; Adriana Rodrigues; Matos, Liliana; Saraiva, J.; Henrique Almeida; Guedes-Martins, L.; Elisabete Silva. "Maternal uterine ageing and placentation". Paper presented in 11th Symposium on Metabolism, 2019.
    Published
  2. F. Timóteo-Ferreira; Sara Mendes; Natalina Alexandra Rocha; Adriana Rodrigues; Matos, Liliana; Henrique Almeida; Elisabete Silva. "Specific antioxidant effect on ovarian ageing". Paper presented in 11th Symposium on Metabolism, 2019.
    Published
  3. Matos, Liliana. "Insights into the contribution of copper to cellular ageing.". Paper presented in 11th Symposium on Metabolism, 2019.
    Published
  4. F. Timóteo-Ferreira; Sara Mendes; Natalina Alexandra Rocha; Matos, Liliana; Adriana Rodrigues; Henrique Almeida; Elisabete Silva. "Improvement of age-related ovarian involution by the use of a NADPH - oxidase inhibitor.". Paper presented in 14th YES Meeting, 2019.
    Published
  5. Mendes, S.; Soares, A. I.; Silveira, S.; Matos, L.; Guedes-Martins, L.; Saraiva, J.; Almeida, H.; Silva, E.. "Uterine protein oxidative modifications may condition trophoblast function". Paper presented in 12th YES Meeting, 2017.
    10.1016/j.pbj.2017.07.118
  6. Soares, A., I; Silveira, S.; Matos, L.; Guedes-Martins, L.; Saraiva, J.; Almeida, H.; Silva, E.. "Maternal age and placenta redox changes". Paper presented in UMIB Summit, 2016.
  7. Sandra Reis; Angela Ribeiro; Matos, Liliana; Silva-Carvalho JL; Alexandra Gouveia; Henrique Almeida. "A granulosa cell line that acquires cumulus oophorus properties - Early characterization". Paper presented in 31st Annual Meeting of theEuropean-Society-of-Human-Reproduction-and-Embryology, 2015.
    Published
  8. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Involvement of unfolded protein response in cellular senescence establishment". Paper presented in 11th International Medical Postgraduate Conference, 2014.
    Published
  9. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "ER stress response activation in cellular senescence.". Paper presented in 5th Symposium on Metabolism, 2013.
    Published
  10. Matos, Liliana; David Stevenson; Florbela Gomes; Silva-carvalho, J.L.; Henrique Almeida. "Assessing Manganese Superoxide Dismutase in cultured human cumulus oophorus cells". Paper presented in 23rd Annual Meeting of the European Society of Human Reproduction and Embryology, 2007.
    Published
  11. Matos, Liliana; Delminda Neves; Henrique Almeida. "Superoxide Dismutase Activity in the Rat Adrenal Gland". Paper presented in 12th International Congress of Endocrinology, 2004.
    Published
Conference poster
  1. Matos, Liliana; Formoso, Inês. Corresponding author: Matos, Liliana. "Evaluation of age-associated cellular and molecular changes on human uterine samples". Paper presented in IJUP 2023, 2023.
  2. Adriana Guerreiro; Elisabete Silva; Henrique Almeida. "Ovarian aging and cellular senescence: an interspecies study.". Paper presented in XVII CONGRESSO INTERNACIONAL VETERINÁRIO MONTENEGRO 2021, 2021.
  3. Ricardo Oliveira; Gouveia, Alexandra; Adriana Raquel Rodrigues. "In vitro assessment of copper capacity to induce cellular senescence and the protective role of alpha-MSH.". Paper presented in IJUP 2021, 2021.
  4. Adriana Guerreiro; Elisabete Silva; Henrique Almeida. "Addressing the role of cellular senescence in female fertility.". Paper presented in IJUP 2021, 2021.
  5. Mafalda Moreira; Andre Silva; Elisabete Silva; Henrique Almeida. "Using decellularized human uterine samples to assess the influence of the extracellular matrix on the age related decay on uterine function.". Paper presented in IJUP 2021, 2021.
  6. David Abreu; Ana Sofia Teixeira; F. Timóteo-Ferreira; Adriana Rodrigues; André Silva; Henrique Almeida; Matos, Liliana; Elisabete Silva. "Reproductive ovarian ageing: a comparison with the liver". Paper presented in IJUP 2020, 2020.
  7. Sara Mendes; F. Timóteo-Ferreira; Adriana Rodrigues; Matos, Liliana; Saraiva, J.; Henrique Almeida; Guedes-Martins, L.; Elisabete Silva. "Maternal uterine ageing and placentation". Paper presented in 11th Symposium on Metabolism, 2019.
  8. F. Timóteo-Ferreira; Sara Mendes; Natalina Alexandra Rocha; Matos, Liliana; Adriana Rodrigues; Henrique Almeida; Elisabete Silva. "Apocynin ameliorates age-related ovarian fertility decline in mice". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  9. Sara Mendes; F. Timóteo-Ferreira; Adriana Rodrigues; Matos, Liliana; Saraiva, J.; Henrique Almeida; Luis Guedes-Martins; Elisabete Silva. "Uterine ageing: protein carbonylation and placentation". Paper presented in Ageing: models, mechanisms and therapies, 2019.
  10. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Activation of Unfolded Protein Response in Human Cellular Models of Senescence". Paper presented in 4º Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto, 2014.
  11. Ana Isabel Soares; Filipe Costa; José Pedro Castro; Matos, Liliana; Henrique Almeida; Elisabete Silva. "Age-related reproductive outcome. Effect of specific antioxidant therapy". Paper presented in I3S 4th Annual Meeting, 2014.
  12. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "ER stress response activation during cellular senescence". Paper presented in I3S 4th Annual Meeting, 2014.
  13. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "ER stress response is activated in in vitro human cellular models of senescence". Paper presented in SFRR Summer School: Biochemical Basis of Healthy Aging, 2014.
  14. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "ER stress response in human cellular models of senescence". Paper presented in 3º Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto, 2013.
  15. Matos, Liliana; Henrique Almeida. "ER Stress Response Activation in Cellular Senescence". Paper presented in 5º Simpósio de Metabolismo na Faculdade de Medicina da Universidade do Porto, 2013.
  16. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Exposure of human fibroblasts to copper leads to premature senescence". Paper presented in I3S 3th Annual Meeting, 2012.
  17. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Metal-induced oxidative stress in human fibroblasts: a role in cellular ageing". Paper presented in 1º Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto, 2011.
  18. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "In vitro exposure of human fibroblasts to copper results in premature senescence.". Paper presented in 3º Simpósio em Metabolismo: Mecanismos moleculares na Síndrome Metabólica, 2011.
  19. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Copper induces premature senescence in human fibroblasts in vitro". Paper presented in 7th European congress of Biogerontology, 2010.
  20. Matos, Liliana; Alexandra Gouveia; Henrique Almeida. "Metal-induced oxidative stress ability to trigger premature senescence in human fibroblasts in vitro". Paper presented in I3S 1st Annual Meeting, 2010.
  21. Matos, Liliana; Henrique Almeida. "The effect of iron-citrate in human fibroblasts in vitro". Paper presented in Biogerontology 2008,, 2008.
  22. Michael Luis; Leal-Seabra F; Matos, Liliana; Adriana Rodrigues; Delminda Neves; Henrique Almeida. "Morphological changes and BAX expression in adrenocortical cells exposed to endotoxin". Paper presented in LINK-AGE Meeting and IBMC Symposium, 2007.
  23. Boilan, E; Debacq-Chainiaux F; Matos, Liliana; Grief J; Osiewacz HD; Toussaint, O. "The effect of copper sulfate on human fibroblasts,". Paper presented in LINK-AGE Meeting and IBMC Symposium, 2007.
  24. Matos, Liliana; Stevenson, D.; Florbela Gomes; Silva-carvalho, J.L.; Henrique Almeida. "Assessing manganese superoxide dismutase in cultured cumulus oophorus cells". Paper presented in European Society of Human Reproduction & Embriology, 2007.
  25. Matos, Liliana; Stevenson, D.; Florbela Gomes; Silva-carvalho, J.L.; Henrique Almeida. "Dismútase do Superóxido Manganês em células do cumulus oophorus humano". Paper presented in 3º Congresso Português de Medicina da Reprodução, 2007.
  26. Fátima Leal-Seabra; Michael Luis; Stevenson, D.; Matos, Liliana; Silva-carvalho, J.L.; Henrique Almeida. "A preliminary assessment of cell cycle and death in human Cumulus Oophorus cells". Paper presented in Young European Scientists (YES) meeting, 2006.
  27. Henrique Almeida; Matos, Liliana; Jorge Ferreira; Delminda Neves. "Age-related effects of dexamethasone administration in adrenal zona reticularis". Paper presented in 11th Congress of International Association of Biomedical Gerontology, 2006.
  28. Matos, Liliana; Delminda Neves; Henrique Almeida. "Adrenal Cortex superoxide dismutase in oxidative stress". Paper presented in Science Research in Pre-Graduation Joint Programme of the University of Porto and Ilídio Pinho Foundation, 2004.
  29. Matos, Liliana; Delminda Neves; Henrique Almeida. "Superóxido Dismutase Manganês (MnSOD) no córtex da Glândula Supra-renal de ratos tratados com dexametasona". Paper presented in XXXIX Reunião da Sociedade de Microscopia Electrónica e Biologia Celular, 2004.
  30. Matos, Liliana; Maria João Ramos. "New Designs For Inhibitors of the NF-kB:DNA Binding". Paper presented in Quitel 2004 -XXX Congresso de Químicos Teóricos de Expressão Latina, 2004.
  31. Matos, Liliana; Maria João Ramos. "Design of 2-cyclopentenone derivatives with enhanced NF-kB: DNA Binding Inhibitory Properties". Paper presented in Quitel 2004 -XXX Congresso de Químicos Teóricos de Expressão Latina, 2004.
  32. Matos, Liliana; Delminda Neves; Henrique Almeida. "Study of Superoxide Dismutase in the Rat Adrenal". Paper presented in 12th International Congress of Endocrinology, 2004.
Journal article
  1. Gouveia, Alexandra; Adriana Raquel Rodrigues; Maria J. Salazar; Almeida, Henrique; Ricardo oliveira. Corresponding author: Gouveia, Alexandra. "High copper levels induce premature senescence in 3T3-L1 preadipocytes". BBA - Molecular Cell Research (2024):
    Accepted
  2. Timóteo-Ferreira, F.; Abreu, D.; Mendes, S.; Matos, L.; Rodrigues, A.R.; Almeida, H.; Silva, E.. "Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention". Ageing Research Reviews 68 (2021): 101345. http://dx.doi.org/10.1016/j.arr.2021.101345.
    Published • 10.1016/j.arr.2021.101345
  3. Mendes, S.; Timóteo-Ferreira, F.; Soares, A.I.; Rodrigues, A.R.; Silva, A.M.N.; Silveira, S.; Matos, L.; et al. "Age-related oxidative modifications to uterine albumin impair extravillous trophoblast cells function". Free Radical Biology and Medicine 152 (2020): 313-322. http://dx.doi.org/10.1016/j.freeradbiomed.2020.03.020.
    10.1016/j.freeradbiomed.2020.03.020
  4. F. Timóteo-Ferreira; S. Mendes; N. A. Rocha; L. Matos; A. R. Rodrigues; H. Almeida; E. Silva. "Apocynin Dietary Supplementation Delays Mouse Ovarian Ageing". Oxidative Medicine and Cellular Longevity (2019): https://doi.org/10.1155/2019/5316984.
    10.1155/2019/5316984
  5. Liliana Matos; Alexandra Monteiro Gouveia; Henrique Almeida. "Erratum to “Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis”". Oxidative Medicine and Cellular Longevity (2017): https://doi.org/10.1155/2017/9172085.
    10.1155/2017/9172085
  6. Freitas, C.; Neto, A.C.; Matos, L.; Silva, E.; Ribeiro, Â.; Silva-Carvalho, J.L.; Almeida, H.. "Follicular Fluid redox involvement for ovarian follicle growth". Journal of Ovarian Research 10 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85023164526&partnerID=MN8TOARS.
    10.1186/s13048-017-0342-3
  7. Ribeiro, A.; Freitas, C.; Matos, L.; Gouveia, A.; Gomes, F.; Silva Carvalho, J.L.; Almeida, H.. "Age-related expression of TGF beta family receptors in human cumulus oophorus cells". Journal of Assisted Reproduction and Genetics 34 9 (2017): 1121-1129. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018389055&partnerID=MN8TOARS.
    10.1007/s10815-017-0930-6
  8. Liliana Matos; Alexandra Monteiro Gouveia; Henrique Almeida. "Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis. *corresponding author". Oxidative Medicine and Cellular Longevity 2017 (2017): 1-12. https://doi.org/10.1155%2F2017%2F3793817.
    10.1155/2017/3793817
  9. Reis, S. A.; Ribeiro, A.; Matos, L.; Silva-Carvalho, J. L.; Gouveia, A. M.; Almeida, H.. "A granulosa cell line that acquires cumulus oophorus properties - Early characterization". Human Reproduction 30 (2015): 308-308. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359740302103&KeyUID=WOS:000359740302103.
  10. Guedes-Martins, L.; Gaio, R.; Saraiva, J.; Cerdeira, S.; Matos, L.; Silva, E.; Macedo, F.; Almeida, H.. "Reference Ranges for uterine artery pulsatility index during the menstrual cycle: A cross-sectional study". PLoS ONE 10 3 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924289939&partnerID=MN8TOARS.
    10.1371/journal.pone.0119103
  11. Matos, L.; Gouveia, A.M.; Almeida, H.. "ER stress response in human cellular models of senescence". Journals of Gerontology - Series A Biological Sciences and Medical Sciences 70 8 (2015): 924-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940896820&partnerID=MN8TOARS.
    10.1093/gerona/glu129
  12. Silva, E.; Soares, A.I.; Costa, F.; Castro, J.P.; Matos, L.; Almeida, H.. "Antioxidant supplementation modulates age-related placental bed morphology and reproductive outcome in mice". Biology of Reproduction 93 3 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84943236013&partnerID=MN8TOARS.
    10.1095/biolreprod.114.127746
  13. Guedes-Martins, L.; Matos, L.; Soares, A.; Silva, E.; Almeida, H.. "AGEs, contributors to placental bed vascular changes leading to preeclampsia". Free Radical Research 47 S1 (2013): 70-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881228672&partnerID=MN8TOARS.
    10.3109/10715762.2013.815347
  14. Matos, L.; Gouveia, A.; Almeida, H.. "Copper ability to induce premature senescence in human fibroblasts". Age 34 4 (2012): 783-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866491060&partnerID=MN8TOARS.
    10.1007/s11357-011-9276-7
  15. Matos, Liliana; Henrique Almeida. "Iron-citrate can induce cell senescent phenotype in human fibroblasts in vitro.". Microscopy and Microanalysis 15 Supp(S3) (2009): 15-16.
    Published • 10.1017/S1431927609990535
  16. Matos, L.; Stevenson, D.; Gomes, F.; Silva-carvalho, J.L.; Almeida, H.. "Superoxide dismutase expression in human cumulus oophorus cells". Molecular Human Reproduction 15 7 (2009): 411-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649233795&partnerID=MN8TOARS.
    10.1093/molehr/gap034
  17. Fátima Leal-Seabra; Matos, Liliana; Henrique Almeida. "Young WI-38 human fibroblasts apoptosis after to staurosporine exposure: a preliminary assessment.". Microscopy and Microanalysis 15 Supp (S3) (2009): 23-24.
    Published
  18. Matos, L.; Stevenson, D.; Gomes, F.; Silva-Carvalho, J.L.; Almeida, H.. "Superoxide dismutase detection in human cumulus oophorus cells". Microscopy and Microanalysis 14 SUPPL. 3 (2008): 99-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-53349107505&partnerID=MN8TOARS.
    10.1017/S1431927608089514
  19. Almeida, H.; Matos, L.; Neves, D.. "Caspase-3 and Bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration". Annals of the New York Academy of Sciences 1119 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-36549004098&partnerID=MN8TOARS.
    10.1196/annals.1404.021
  20. Almeida, H.; Matos, L.; Ferreira, J.; Neves, D.. "Age-related effects of dexamethasone administration in adrenal zona reticularis". Annals of the New York Academy of Sciences 1067 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33744464769&partnerID=MN8TOARS.
    10.1196/annals.1354.050
  21. Fernandes, P.A.; Henriques, E.S.; Pande, V.; Ramos, M.J.; Maia, A.R.R.; Almeida, A.A.S.; Silva, B.F.B.; et al. "New designs for inhibitors of the NF-kB: DNA binding". Theoretical Chemistry Accounts 113 4 (2005): 197-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-21044448195&partnerID=MN8TOARS.
    10.1007/s00214-005-0628-1
  22. Fernandes, P.A.; Cruz, A.I.S.; Maia, A.R.R.; Almeida, A.A.S.; Da Silva, A.M.N.; Silva, B.F.B.; Ribeiro, C.M.S.; et al. "Design of 2-cyclopentenone derivatives with enhanced NF-¿B: DNA binding inhibitory properties". Journal of Molecular Structure: THEOCHEM 685 1-3 (2004): 73-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-6944250787&partnerID=MN8TOARS.
    10.1016/j.theochem.2004.06.027
Thesis / Dissertation
  1. Matos, Liliana. "Metal-induced oxidative stress in human fibroblasts: a role in cellular ageing". PhD, Universidade do Porto Faculdade de Medicina, 2015.
  2. Matos, Liliana. "Dismutases do anião superóxido nas células do cumulus oophorus humanas". Master, Universidade do Porto Faculdade de Medicina, 2008.
  3. Matos, Liliana. "O córtex Supra-Renal no stress oxidativo". Degree, Universidade do Porto Faculdade de Ciências, 2005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10 Insights into the contribution of copper to cellular ageing. 11th Symposium on Metabolism
Faculdade de Medicina, Universidade do Porto (Porto, Portugal)
2019/02 Exploring the role of uterine oxidative protein modifications in defective placentation IJUP 2019
(Porto, Portugal)
2019/02 Antioxidant supplementation. A future way for delaying ovarian ageing? IJUP 2019
(Porto, Portugal)
2019 Improvement of age-related ovarian involution by the use of a NADPH - oxidase inhibitor 14th YES Meeting
(Porto, Portugal)
2019 Unveiling the role of uterine oxidative protein modifications as a contributor to a defective placentation XLIX Reunião Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2019 Effects of antioxidant supplementation in ovarian ageing XLIX Reunião Sociedade Portuguesa de Farmacologia
(Porto, Portugal)
2018/02 Exploring the role of oxidative protein modifications in trophoblast function IJUP 2018
(Porto, Portugal)
2017/09 Dual effect of anti-oxidant treatment on reproductive ovarian aging. I3S 6th Annual Meeting
(Póvoa de Varzim, Portugal)
2017/02 Fibrosis correlates to uterine and ovarian reproductive ageing IJUP 2017
(Porto, Portugal)
2014/11 Involvement of unfolded protein response in cellular senescence establishment 11th International Medical Postgraduate Conference: New Frontiers in the Research of PhD Students
(Hradec Králové, Czech Republic)
2014/10 Modelos de Estudo da Senescência Celular Encontro científico: O envelhecimento numa perspectiva celular e molecular
Escola Superior de Tecnologia da Saúde do Porto (Vila Nova de Gaia, Portugal)
2014/09 ER stress response is activated in in vitro human cellular models of senescence. SFRR Summer School: Biochemical Basis of Healthy Aging
(Spetses, Greece)
2014/09 Reproductive ageing and antioxidants: effect in uterine function 9th Young Scientist Meeting (Yes Meeting)
(Porto, Portugal)
2014/02 Aged female diet anti-oxidant supplementation: effect on placental bed reproductive outcome IJUP 2014
(Porto, Portugal)
2012/06 Cellular response to stress: models for the study of ageing Stress na saúde e na doença - Programa Doutoral em Neurociências
Faculdade de Medicina, Universidade do Porto (Porto, Portugal)
2011/10 In vitro exposure of human fibroblasts to copper results in premature senescence 3º Simpósio em Metabolismo: Mecanismos moleculares na Síndrome Metabólica,
Faculdade de Medicina, Universidade do Porto (Porto, Portugal)
2009/04 Dismútases do Superóxido nas células do cumulus oophorus humanas Curso livre em Radicais, Stresse oxidativo e Antioxidantes
Faculdade de Medicina, Universidade do Porto (Porto, Portugal)
2008/11/30 Cumulus oophorus cells (COCs) in functionally aged human ovary. LINK-AGE Working Research Group A and Working Research Group on Model systems
(Noordwijkerhout, Netherlands)
2008/10 Iron-citrate can induce cell senescent phenotype in human fibroblasts in vitro INCOMAM’08
(Porto, Portugal)
2007/12 Human Cumulus Oophorus Primary Culture and Superoxide Dismutase Detection INCOMAM’07
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - 2024 Proteomic characterization of human uterine samples during reproductive ageing
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2023 Characterization of age-associated cellular and molecular uterine alterations in human samples
Supervisor
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09 - 2021/09 New insights into the role of extracellular matrix on human decidualization
Supervisor of Mafalda Alexandra da Rocha Moreira
 Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/17 - 2020/07/23 Estudo da Oxidação Proteica em Diferentes Modelos de Senescência Celular Prematura Induzida por Stress
Co-supervisor of Paulo Jorge Cardoso Pinheiro
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/17 - 2020/07/23 Influence of Extracellular Matrix on Human Uterine Function: a Preliminary Approach
Supervisor of Teodora Garcia Lema Figueiredo
Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/14 - 2020/07 Cellular senescence and ovarian ageing.
Co-supervisor of David Abreu
 Biologia (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019 - 2019 Participation as collaborator in "Escola de Ciências da Vida e da Saúde" (1 week/year) - University of Porto
Other
 Escola de Ciências da Vida e da Saúde
Universidade do Porto, Portugal
2007 - 2017 Anual participation as collaborator in "Escola de Ciências da Vida e da Saúde" (1 week/year) - University of Porto
Other
 Escola de Ciências da Vida e da Saúde
Universidade do Porto, Portugal
2007 - 2009 Anual participation as monitor in "Universidade Júnior/Verão em projecto (2 weeks/year) - Faculty of Medicine, University of Porto
Other
 Universidade Júnior
Universidade do Porto, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2016 - Current Cellular and Molecular Biology sessions. Medicina Dentária (Mestrado integrado) Universidade do Porto Faculdade de Medicina Dentária, Portugal
2014 - Current Cell models. Replicative senescence and Stress Induced Premature Senescence Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Cell models. Replicative senescence and Stress Induced Premature Senescence Medicina e Oncologia Molecular (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2014 - Current Envelhecimento celular: O modelo de Hayflick e o induzido por stress; O retículo endoplasmático na resposta ao stress intracelular Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2006 - Current Cellular and Molecular Biology - practical lessons Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2019/04/01 - 2019/06/30 Dinâmica Molecular da Célula Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current ACS Omega (2470-1343) American Chemical Society
2019 - 2019 Drug and Chemical Toxicology
2019 - 2019 Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2016 - 2016 Experimental Gerontology (0531-5565) Elsevier
2012 - 2012 AGE (1574-4647) Springer-Verlag
Distinctions

Award

2014 Prize for oral presentation in the 11th International Medical Postgraduate Conference, Hradec Kralové, Czech Republic
Organization for PhD Education in Biomedicine and Health Sciences in the European System (ORPHEUS), Czech Republic
2014 Travel Grant and Fee to attend SFRR Summer School: Biochemical Basis of Healthy Aging, Greece (awarded by COST Action CM1001)
2013 Best poster presentation in 3º Encontro de doutorandos
Universidade do Porto Faculdade de Medicina, Portugal
2011 Crioestaminal award for Research in Gynecology and Obstetrics as a member of the team for the project entitled “Redox balance in placental bed as modulator of older women pregnancies”
Federação das Sociedades Portuguesas de Obstetricia e Ginecologia FSPOG, Portugal

Crioestaminal, Portugal
2005 Best Poster in Health Sciences
Universidade do Porto, Portugal

Fundação Ílidio Pinho, Portugal