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My research is focused on clarifying the molecular mechanisms of neurodegeneration in the context of ageing diseases, such as retinal degeneration and Parkinson's disease. In April 2022, I became a Principal Investigator and Group Leader of the Degeneration and Ageing Lab at NMS-UNL. Since 2010, I have secured independent funding as Principal Investigator (PI) and Co-PI in several research projects for my research lines (total: 537 K). I am also collaborating with ophthalmologists and actively involved in clinical studies (ClinicalTrials.gov database identifier: NCT06355830). Moreover, I participated extensively in advanced training. I supervised 6 post-docs (5 concluded), 7 PhD students (4 concluded), 21 MSc students (19 concluded), 19 concluded scientific traineeships, and managed 7 research assistants. I have also been involved in PhD thesis committees at different universities (6). In this role, I evaluate thesis progress, offer guidance on future directions, and help students achieve successful outcomes. I have also served as a jury member for PhD (9) and MSc (10) defences across multiple universities. Moreover, I had the privilege of lecturing in PhD and MSc programs, and post-graduation courses, at various institutions. I am a member of the Management Committee (MC) of COST ActionBenBedPhar, "Bench to bedside transition for pharmacological regulation of NRF2 in non-communicable diseases" (CA20121, 2021-2025). I have 1 patent under review ( Application EP22217331.2; PCT/IB2023/062075). In my scientific career, I achieved 60 peer-reviewed publications (including a book chapter). I am the first author of 15, co-corresponding author of 5, and the only corresponding author of 2 of these articles. My publications have been cited ~3300 (according to Scopus). Currently, my H-INDEX is 32 (according to Scopus). I had 2 career breaks: 3 children born in 2005 and 2010 (twins).
Identification

Personal identification

Full name
Sandra Isabel Nogueira Tenreiro

Citation names

  • Tenreiro, Sandra
  • Tenreiro, S

Author identifiers

Ciência ID
2214-5455-2764
ORCID iD
0000-0001-7272-5842
Researcher Id
A-9289-2013
Scopus Author Id
6602925840

Email addresses

  • stenreiro@nms.unl.pt (Professional)
  • stenreiro@gmail.com (Personal)

Addresses

  • Nova Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa (NMS|FCM-UNL), Rua Câmara Pestana nº 6-A, 1150-082, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Beginner (A1) Intermediate (B1)
Portuguese (Mother tongue)
French Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2017/02 - 2017/03
Concluded
Laboratory Animal Science course from SPCAL functions A, C and D for rodents and fishes / FELASA Cat.B (Outros)
Major in Laboratory Animal Science
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
18/20
1997 - 2001/09/27
Concluded
PhD in Biotechnology (Doutoramento)
Major in Molecular Genetics
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Functional Analysis of new genes of saccharomyces cerevisiae encoding putative multidrug transporters from the major facilitator superfamily" (THESIS/DISSERTATION)
Approved (only classification available)
1993 - 1995/12/15
Concluded
MSc in Cell Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Isolation, characterization and description of two new species belonging to the genus Thermus" (THESIS/DISSERTATION)
Very good
1988 - 1993/07/23
Concluded
BSc in Biochemistry (5 years degree) (Licenciatura)
Major in Microbiology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Chemotaxonomic characterization of thermophilic bacteria" (THESIS/DISSERTATION)
70 %
Affiliation

Science

Category
Host institution
Employer
2022/04/01 - Current Principal Investigator (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/12/01 - 2022/03/31 Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/02/02 - 2018/11/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/02/02 - 2018/02/01 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013/09/01 - 2015/01/31 Principal Investigator (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2008/02/01 - 2013/08/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2001/10/01 - 2008/01/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
1996/01/01 - 1996/11/30 Research Assistant (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Université Libre de Bruxelles, Belgium

Teaching in Higher Education

Category
Host institution
Employer
2021/09/01 - 2022/07/31 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/09/01 - 2018/11/30 Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013/05/01 - 2013/07/31 Invited Assistant Professor (University Teacher) Universidade Lusófona, Portugal
Universidade Lusófona, Portugal
2009/05/01 - 2010/03/31 Invited Assistant Professor (University Teacher) Universidade Lusófona, Portugal
Universidade Lusófona, Portugal

Others

Category
Host institution
Employer
1998/12/01 - 2001/09/27 PhD student Project: Functional analysis of new Saccharomyces cerevisiae genes encoding putative multidrug transporters from the major facilitator superfamily Supervision: Prof. Isabel Sá-Correia Universidade de Lisboa Instituto Superior Técnico, Portugal
1998/09/01 - 1998/11/30 PhD student Project: Identification of new determinants of multidrug resistance in S. cerevisiae Supervision: Prof. Bruno André Université Libre de Bruxelles, Belgium
1998/03/01 - 1998/08/30 PhD student Project: Identification of new determinants of multidrug resistance in S. cerevisiae Supervision: Prof. André Goffeau Université catholique de Louvai Ecole de Biologie, Belgium
1997/01/01 - 1998/02/28 PhD student Project: Functional analysis of new Saccharomyces cerevisiae genes encoding putative multidrug transporters from the major facilitator superfamily Supervision: Prof. Isabel Sá-Correia Universidade de Lisboa Instituto Superior Técnico, Portugal
1993/09/01 - 1995/12/15 MSc student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projects

Grant

Designation Funders
2023/07/01 - Current "The role of extracellular vesicles in the progression of diabetic retinopathy through the gut-liver-retina axis" Exploratory project funded by EVCA Twinning Project (GA 101079264)
--
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Horizon 2020
Ongoing
2022/03/11 - 2023/09/10 Exploring a human retinal organoid model of early Diabetic Retinopathy for drug discovery (5Keuros)
CC-SPD 2022
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Sociedade Portuguesa de Diabetologia
Concluded
2021/10/01 - 2022/09/30 Modeling hyperglycemia through human retinal organoids: a 3D model of early Diabetic retinopathy for drug discovering (6Keuros)
-
Principal investigator
iNOVA4Health, Portugal
iNOVA4Health
Concluded
2021/09/01 - 2022/08/31 Exosomes in transcellular proteostasis and Age-Related Macular Degeneration (Co-PI)
--
Co-Principal Investigator (Co-PI)
iNOVA4Health, Portugal
iNOVA4Health
Concluded
2018/10/01 - 2022/06/30 FCT project: Lysosome dysfunction in age-related diseases
PTDC/MED-PAT/30385/2017
Researcher
Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/02/01 - 2018/11/30 Recovering neuronal function and promoting neuroprotection in diabetic retinopathy
SFRH/BPD/101646/2014
Post-doc Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/02/01 - 2018/01/31 Dissecting the role of alpha-synuclein phosphorylation in Parkinson's disease
SFRH/BPD/101646/2014
Post-doc Fellow
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/10/01 - 2015/01/31 Deciphering the Role of alpha-Synuclein Phosphorylation in Parkinson's Disease (Part II)
SFRH/BPD/35767/2007
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01 - 2011/12 Implementation of a Nacional Facility for DNA Microarrays: Phase II
PTDC/BIA-BCM/64745/2006
Post-doc
Universidade de Aveiro Centro de Estudos do Ambiente e do Mar, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/10/01 - 2011/09/30 Mendelian Forms of Parkinson’s Disease
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
2008/02/01 - 2010/09/30 Deciphering the Role of alpha-Synuclein Phosphorylation in Parkinson's Disease (Part I)
SFRH/BPD/35767/2007
Post-doc Fellow
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2001/10/01 - 2008/01/31 Studies oriented by genomics on the multidrug resistance in Saccharomyces cerevisiae
BPD/5649/2001
Post-doc Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1997/10/01 - 2001/09/01 Functional analysis of new Saccharomyces cerevisiae genes encoding putative multidrug transporters from the major facilitator superfamily
BD/9633/96
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded

Contract

Designation Funders
2023/01/15 - Current Extracellular vesicles are critical players in the transcellular regulation of proteostasis in Age-related Macular Degeneration
Researcher
Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/12/01 - Current NASCENT - NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration - La Caixa HR22-00569
HR22-00569
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
La Caixa Foundation
Ongoing
2022/11/01 - Current Centre for Excellence in Diagnostic and Advanced Therapeutics based on Extracellular Vesicles - ECVA Twinning Project
Horizon GA nº 101079264
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
European Union
Ongoing
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/12/31 The role of necroptosis in Choroideremia
Researcher
Universidade NOVA de Lisboa NOVA Medical School, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/01/01 - 2023/06/30 A gene-editing nanoparticle formulation for retinal degeneration diseases
EXPL/BIA-CEL/0989/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/05/31 Mechanistic and optogenetic control of astroglia for neural repair
PTDC/MED-NEU/31417/2017
Researcher
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2021/05/01 - 2022/04/30 Mechanisms of Cell Death in Chroideremia
-
Researcher
Universidade Nova de Lisboa, Portugal
Fight for Sight
Concluded
2018/10 - 2022/03/31 Recovering neuronal function and promoting neuroprotection in diabetic retinopathy (240Keuros)
PTDC/MED-PAT/29656/2017
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/05/07 - 2020/09/30 Bioengineered in vitro model of retinal pigmented epithelium of human eye
M-ERA-NET2/0005/2016
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2018/07/01 - 2020/06/30 Mechanisms of Cell Death in Choroideremia
Researcher
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Choroideremia Research Foundation, Inc
Concluded
2016/06/01 - 2020/02/29 Antiglycation defenses as a therapeutic target for Parkinson's disease
PTDC/NEU-OSD/5644/2014
Researcher
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 iNOVA4Health - Programa de Medicina Translacional iBET, CEDOC/FCM, IPOLFG e ITQB
UID/Multi/04462/2019
Instituto de Biologia Experimental e Tecnológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2017/10/01 - 2019/12/31 Correction of lysosomal dysfunction in Retinal Pigmented Epithelial cells
-
Researcher
Universidade Nova de Lisboa, Portugal
Boehringer Ingelheim Auslandsbeteiligungs GmbH
Concluded
2016/05 - 2018/04 SynDia: Synucleins - the link between Parkinson´s disease and Diabetic Retinopathy? (58K€)
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
iNOVA4Health
Concluded
2012/01/01 - 2015/06/30 The role and regulation of alpha-synuclein phosphorylation in both pathological and physiological conditions (168K€)
Principal investigator
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e Tecnologia
Concluded
2011/02/01 - 2014/05/31 Polyphenols as protective agents in cellular models of alpha-synucleinopaties, in particular Parkinson's disease (Co-Principal Investigagor)
Co-Principal Investigator (Co-PI)
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/30 MEFOPA - European Project on Mendelian Forms of Parkinson's Disease
ID: 241791
Post-doc
Instituto de Medicina Molecular, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2010/02/05 - 2013/07/31 Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF
PTDC/SAU-NEU/101928/2008
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/07/31 Da fosforilação à clivagem: um "switch" para a agregação e a toxicidade da alfa-sinucleína
PTDC/SAU-NEU/105215/2008
Post-doc
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/02/17 Projecto Estratégico - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010 - 2013 Academic-Industrial Initial Training Network (ITN) on Alpha-Synuclein Related Brain Diseases
ID: 238316
Post-doc
Instituto de Medicina Molecular, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2008/02/01 - 2011/09/02 NEUROFOLD - Deciphering the molecular basis of neurodegenerative diseases associated with protein misfolding for the development of novel therapeutics
ID: 203312
Post-doc
Instituto de Medicina Molecular, Portugal
European Commission Seventh Framework Programme for Research and Technological Development
Concluded
2008/01/01 - 2011/02/28 RESISTÊNCIA AO IMATINIB E SEUS ALVOS NA LEUCEMIA CRÓNICA MIELOIDE: ABORDAGENS PÓS-GENÓMICAS USANDO A LEVEDURA COMO SISTEMA MODELO
PTDC/SAU-FCF/71760/2006
Post-doc
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/09/12 - 2010/11/10 Caracterização e modelação de uma rede de regulação transcricional específica envolvida na resistência a múltiplas drogas em levedura
PTDC/BIO/72063/2006
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2006/01/02 - 2008/01/01 Elucidação das complexas redes de regulação que actuam na levedura sujeita a drogas/stresse químico: abordagens de expressão genómica e de bioinformática
PDCT/BIO/56838/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2007/12/31 DBYeast: Infraestruturas e algoritmos para análise e identificação de redes de regulação genética
POSC/EIA/57398/2004
Post-doc
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2000/01/01 - 2002/12/31 HERBICBIOREM - Strategies to accelerate the productive biodegradation of several herbicides under environmental stress condition.
QLK3-CT-1999-00041
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
European Commission
Concluded
1997/10/01 - 2000/07/31 BIOTECH EUROFAN (fase II), European network for the functional analysis of yeast genes discovered by systematic DNA sequencing
BIO4-CT97-2294
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
European Commission
Concluded
1995/12/01 - 1998/10/31 BIOTECH EUROFAN (fase I), European network for the functional analysis of yeast genes discovered by systematic DNA sequencing,
BIO4-CT95-0080
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
European Commission
Concluded
1993/09/01 - 1995/08/31 Biotechnology of Extremophiles
BIO2-CT93-0274
Scientific Initiation Fellow
Concluded

Other

Designation Funders
2019/01/01 - Current Intermediate Age-related Macular Degeneration - MultimodalAnalysis and Longitudinal Study (Imaging4iAMD) (ClinicalTrials.gov database identifier: NCT06355830) ROLE: STUDY CHAIR
Centro Hospitalar de Lisboa Central EPE, Portugal
Ongoing
Outputs

Publications

Book chapter
  1. Tenreiro, Sandra; Paulo Pereira; Vieira, Otília V; Guimas Almeida, Claudia; Vicente Miranda, Hugo; Helena Vieira; Miguel C. Seabra. "Age-related diseases: common mechanisms and therapeutic approaches". In "Life Molecules to Global Health" - 150th anniversary Alfredo da Silva, edited by José Fragata. Lisbon, Portugal: Universidade Nova de Lisboa and Fundação Amélia de Mello, 2021.
    Published
  2. Tenreiro, Sandra; Macedo, Diana; Marijanovic, Zrinka; Outeiro, Tiago Fleming. Corresponding author: Tenreiro, Sandra. "Analysis of Protein Oligomeric Species by Sucrose Gradients". In Methods in Molecular Biology, edited by Rune Mattiesen, 331-339. Springer New York, 2016.
    Published • 10.1007/978-1-4939-3756-1_21
Conference abstract
  1. De Acutis, A.; De Maria, C.; Heliak, M.; Swieszkowski, W.; Tenreiro, S; Seabra, M.; Vozzi, G.. "Design and Fabrication of an Organ-on-a-chip Technology As a Physiologically Relevant in Vitro Model of the Outer Blood-retinal Barrier". Paper presented in Tissue Engineering - Part A, 2023.
    Published
  2. Miguel C. Seabra; Ana S. Falcão; Mafalda Lopes-da-Silva; ANTAS, PEDRO; Ana C. Fradinho; Luisa Lemos; Thomas Ciossek; et al. Corresponding author: Miguel C. Seabra. "TFEB-mediated reduction of autofluorescent granule load in retinal pigment epithelium". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2022.
    Published
  3. Falcão AS; Escrevente, Cristina; ANTAS, PEDRO; Lopes-da-Silva, Mafalda; Ferreira, I.; Cardoso, MH; Tenreiro, S; Seabra, MC. "Dissecting the role of TFEB in autofluorescent granule load formation and degradation in retinal pigment epithelium". Paper presented in Cell Bio virtual 2021 - ASCB|EMBO meeting, 2021.
  4. Rita Flores; Angela Carneiro; Nery-Pires, Guilherme; Tenreiro, Sandra; Miguel C. Seabra. "Impairement of chorioretinal vasculature in patients with intermediate age-related macular degeneration.". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
    Published
  5. Miguel C. Seabra; Cristina Escrevente; Ana Sofia Falcão; Michael J Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel Mesquita; et al. "Formation of lipofuscin-like autofluorescent granules in the retinal pigment epithelium requires lysosome dysfunction". Paper presented in ARVO Annual Meeting - Investigative Ophthalmology & Visual Science, 2021.
    Published
  6. Pancetta, G; De Acutis, A; Fradinho, AC; Montemurro, F; Cardoso, MH; Heljak, M; De Maria, C; et al. "Design and Fabrication of an organ-on-a-chip technology as a physiologically relevant in vitro model of the outer Blood-Retinal Barrier". Paper presented in Biofabrication (postponed), 2021.
    Submitted
  7. Flores, Rita; Ana Luisa Basilio; Nuno Moura-Coelho; Margarida Marques; Luisa Vieira; Joana Cardigos; Ines Fragoeir0; et al. "Novel disease progression biomarkers in non-exudative age-related macular degeneration: an association study between drusen type and morphology and Fundus Autofluorescence". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  8. Miguel C Seabra; Helena Cardoso; Michael Hall; A. Sofia Falcão; Cristina Escrevente; Pedro Antas; Gabriela V. Santos; Tenreiro, Sandra; Clare E. Futter. "Modeling lysosomal dysfunction in the retinal pigmented epithelium to study pathogenesis of age-related macular degeneration". Paper presented in ARVO Annual Meeting, Vancouver, 2019.
    Published
  9. Cardoso, MH; Hall, M; Falcão, AS; Escrevente, C; Santos, G; Tenreiro, S; Futter, CE; Seabra, MC. "Aging in the Retina: hESc-derived Retinal Pigment Epithelium model of chronic lysosomal dysfunction". Paper presented in Cell Aging and Metabolism, Sitges, Spain, 2018.
    Published
Conference paper
  1. Daniela Silva; J. Teixeira; Zelia Lumarck; Tenreiro, Sandra; M. Sema-Oom; Ana Paula Valagão Amadeu do Serro. Corresponding author: Ana Paula Valagão Amadeu do Serro. "Citicoline eluting soft contact lenses for the treatment of neurodegenerative diabetic ocular diseases". Paper presented in XV Spanish-Portuguese Conference on Controlled Drug Delivery, Lisbon, 2024.
    Published
  2. Falcão AS; Tenreiro, S; Seabra, MC. "NRF2 as a therapeutic target in early and intermediate age-related macular degeneration". Paper presented in 8th International Symposium on Age-related Macular Degeneration, Baden Baden, 2023.
  3. Fernandes, J.T.S.; Tenreiro, S.; Pedrosa, C.R.; Gameiro, A.; Chu, V.; Outeiro, T.F.; Conde, J.P.. "Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alphasynuclein toxicity in yeast". 2014.
    10.1016/j.proeng.2014.11.273
  4. Dos Santos, S.C.; Palma, M.; Tenreiro, S.; Mira, N.P.; Moreira, A.; Sá-Correia, I.. "Identification of targets and mechanisms of resistance to imatinib and quinine using a molecular systems biology approach". 2011.
    10.1109/ENBENG.2011.6026077
Conference poster
  1. Macedo, Luana; Felgueiras, Beatriz; Burrinha, Tatiana; Herrera, Federico; Macedo, Maria Paula; Tenreiro, Sandra; de Oliveira, Rita Machado. Corresponding author: de Oliveira, Rita Machado. "The role of extracellular vesicles in the progression of diabetic retinopathy through the gut-liver-retina axis". Paper presented in MPS_NOVA Twinning kick-off meeting, 2024.
  2. Felgueiras, Beatriz; Macedo, Luana; de Lemos, Luisa; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Exploring a retina organoid model of early Diabetic Retinopathy for drug discovery". Paper presented in MPS_NOVA Twinning kick-off meeting, 2024.
  3. San Juan A, Nicol; Tran Allison DNN; Noel Nicole C; Hunter C; Spencer-Carreira, Olga; Tenreiro, Sandra; Mullins Robert F; Willis L; Carr BJ. Corresponding author: Carr BJ. "Polysialic Acid: A versatile marker for Müller glia in common model organisms and systems". Paper presented in Keystone Symposia. Targeting Dry Age-Related Macular Degeneration: Pathophysiology and Emerging Therapies, 2024.
  4. Olga Carreira; Santos, Inês Paz; de Lemos, Luisa; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modelling retinal degenerative mechanisms using 3D Retinal Organoids (BEST POSTER AWARD)". Paper presented in iPSZu¨rich 2024 Symposium, 2024.
  5. Carreira, Olga; Santos, Inês Paz; Felgueiras, Beatriz; de Lemos, Luísa; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Unraveling the Pathophysiological Impact of a-Synuclein in the Retina through the use of Retinal Organoids". Paper presented in EMBO Workshop Proteostasis: From translation to degradation, Ericeira, Portugal, 2023.
  6. Margarida Pedro; Ana Sofia Falcão; Lopes-da-Silva, Mafalda; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Assessment of transcription factors nuclear translocation in stimulated human RPE cells by microscopy imaging". Paper presented in Spanish Portuguese Meeting for Advanced Optical Microscopy meeting 2023, Faro, Portugal, 2023.
  7. Margarida Pedro; Ana S. Falcão; Rafael León; Santos, Cláudia N.; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Development of a screening pipeline to identify modulators of NRF2 activity". Paper presented in iMED Innovate Competition 15.0, Lisbon, Portugal, 2023.
  8. Ana S Falcão; Margarida Pedro; ANTAS, PEDRO; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Using CRISPR/Cas9 to knock-out the NRF2 gene in retinal pigment epithelium cells.". Paper presented in 5th-BenBedPhar-meeting (COST ACTION 20121), Graz, Austria, 2023.
  9. Fonseca, Ana F.; Oliveira, Daniela; Coelho, Rita A.; Carvalho, Cláudia; de Lemos, Luísa; Lopes-da-Silva, Mafalda; Tenreiro, Sandra; Seabra, Miguel C.. "Genome editing of induced pluripotent stem cells using CRISPR/Cas to model choroideremia disease". Paper presented in 20th International Symposium on Retinal Degeneration, Torremolinos, Andalusia, Spain, 2023.
  10. de Lemos, Luisa; ANTAS, PEDRO; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "3D human retinal organoid model for the study of early diabetic retinopathy". Paper presented in 2nd Microphysiological Systems World Summit, 2023.
  11. Felgueiras, Beatriz; Macedo, Maria Paula; de Oliveira, Rita; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Exploring the role of Gut and Liver-Derived Extracellular Vesicles on Diabetic Retinopathy Progression using Retinal Organoid". Paper presented in 2º Portuguese Network on Extracellular Vesicles, Lisbon, Portugal, 2023.
  12. de Lemos, Luísa; ANTAS, PEDRO; Mariana Castro; Ana Fonseca; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Non-viral mRNA delivery in 3D and 3D human eye cell models". Paper presented in CorEuStem symposium, Champalimaud, Lisbon, Portugal, 2023.
  13. Felgueiras, M. Beatriz; de Lemos, Luísa; Nunes dos Santos, Cláudia; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Exploring a retinal organoid model of early Diabetic Retinopathy for drug discovery". Paper presented in Beyond REMODEL: 3R models for biomedical research, Porto, Portugal, 2023.
  14. Olga Carreira; Santos, Inês Paz; de Lemos, Luísa; Nunes dos Santos, Cláudia; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modelling retinal degenerative mechanisms using patient-derived organoids". Paper presented in Beyond REMODEL: 3R models for biomedical research, Porto, Portugal, 2023.
  15. Vicente Miguel; Ana Sofia Falcão; Margarida Pedro; Tomás Guerreiro; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Effect of repurposed drugs on autofluorescent granule accumulation in a cellular model of age-related macular degeneration". Paper presented in 4th Benbedphar meeting, CA 20121, Zagreb, Croatia, 2023.
  16. Tenreiro, Sandra; de Lemos, Luísa; Felgueiras, M. Beatriz. Corresponding author: Tenreiro, Sandra. "Validation of markers for screening protective molecules in the context of diabetic retinopathy in a retinal organoid model". Paper presented in 19.º Congresso Português de Diabetes, 2023.
  17. Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Connecting the dots on cellular ageing and age-related diseases". Paper presented in LS4FUTURE – 1st General Meeting, 2023.
  18. Tenreiro, Sandra; de Lemos, Luísa; Felgueiras, Beatriz. Corresponding author: Tenreiro, Sandra. "Validação de marcadores para screening de moléculas protetoras no contexto da retinopatia diabética num modelo de organoides de retina". Paper presented in 19º Congresso Português de Diabetes, 2023.
  19. Covas, Rita; de Lemos, Luísa; Tenreiro, Sandra; Bekman, Evguenia P.; Ferreira, Carla; Quintas, Alexandre. Corresponding author: Quintas, Alexandre. "Development of an organoid-based model to study prenatal exposure to cannabinoids". Paper presented in iMED Innovate Competition 14.0, 2022.
  20. Marta Cação; de Lemos, Luísa; Miguel C. Seabra; Nunes dos Santos, Cláudia; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Evaluating the protective effect of berries-derived polyphenol metabolites in mouse retina degeneration (BEST POSTER AWARD)". Paper presented in iMED Innovate Competition 14.0, 2022.
  21. Covas, Rita; Ferreira, Carla; de Lemos, L; Tenreiro, Sandra; Quintas, Alexandre; Bekman, Evguenia P.. Corresponding author: Bekman, Evguenia P.. "Evaluating THC and CBD effects on an organoid-based model of prenatal exposure". Paper presented in VIII International Congress of Forensic Sciences and Criminal Behaviour, 2022.
  22. Ana C. Fradinho; Telmo Pereira; Diogo Cabral; Dong An; Chandrakunar Balaratnasingam; Miguel C. Seabra; Freund, K. Bailey; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Development of medical imaging tools for optical coherence tomography analysis in ocular diseases". Paper presented in LYSOCIL Final Conference, 2022.
  23. Rita Coelho; Daniela Oliveira; Pedro Antas; Mafalda Lopes da Silva; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Characterization of cellular organelles and the endo-lysosomal pathway in choroideremia patient cells". Paper presented in LYSOCIL Final Conference, 2022.
  24. Inês Paz Santos; Luísa Lemos; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Effects of a-synuclein overexpression in retinal degeneration: a 3D organoid approach". Paper presented in Cell Bio Virtual - ASCB/EMBO Online Meeting, 2021.
  25. Luisa Lemos; Pedro Antas; Ines Paz Santos; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling hyperglycemia and retinal degeneration using human retinal organoids". Paper presented in Cell Bio virtual 2021 - ASCB|EMBO meeting, 2021.
  26. Inês Paz Santos; Luísa Lemos; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modelling retinal degenerative mechanisms using patient-derived organoids". Paper presented in 3rd NMS Symposium, 2021.
  27. Luísa Lemos; ANTAS, PEDRO; Inês Santos; Miguel Ferreira; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degeneration by hyperglycemia using 3D human organoids". Paper presented in Organoids With]Out[ Borders Online symposium, 2020.
  28. Luísa Lemos; ANTAS, PEDRO; Inês Ferreira; Daniela Dias; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degeneration by hyperglycemia and oxidative stress using 3D human organoids.". Paper presented in EMBO|EMBL Symposium: Organoids: Modeling Organ development and disease in 3D cell culture., 2020.
  29. Luísa Lemos; ANTAS, PEDRO; Inês Ferreira; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degenerative diseases with 3D human organoids.". Paper presented in EMBO Workshop Proteostasis: From organelles to organims., 2019.
  30. ANTAS, PEDRO; Tenreiro, Sandra; Miguel C. Seabra. Corresponding author: Miguel C. Seabra. "Mechanisms of cell death in Choroideremia". Paper presented in EMBO workshop Proteostasis: From organelles to organisms, 2019.
  31. Lopes da Silva, Mafalda; Ana Sofia Falcão; Cristina Escrevente; Inês Ferreira; Tenreiro, Sandra; Miguel C. Seabra. "Using CLEM to unravel intracellular membrane trafficking defects". Paper presented in SPAOM Spanish and Portuguese Advanced Optical Microscopy meeting, 2019.
  32. Inês Ferreira; Luísa Lemos; ANTAS, PEDRO; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "3D human retinal organoids as a model for dissecting retinal disease microenvironment.". Paper presented in Champalimaud Research Symposium ¿Tissue Environment in Heath and Disease, 2019.
  33. Ana S. Falcão; Maria H. Cardoso; Michael Hall; Cristina Escrevente; Pedro Antas; Miguel Chaves-Ferreira; Tenreiro, Sandra; Clare E. Futter; Miguel C. Seabra. "Dissecting the role of lysosome dysfunction in age-related macular degeneration". Paper presented in VII International DOG-Symposium on AMD, 2019.
  34. Ana C. Fradinho; Maria H. Cardoso; Miguel Chaves-Ferreira; D Cuffaro; Carmelo De Maria; Elisa Nuti; A Rossello; et al. Corresponding author: Miguel C. Seabra. "Bioengineered in vitro model of retinal pigment epithelium as better 3D drug testing model system in AMD". Paper presented in LYSOCIL workshop, Lisboa, Portugal, 2019.
  35. Escrevente, Cristina; Falcão, Ana Sofia; Cardoso, Maria Helena; Ferreira, Inês; Tenreiro, Sandra; Seabra, Miguel. "Unravelling the role of lysosome dysfunction in the pathogenesis of age-related macular degeneration (AMD)". Paper presented in Workshop on Lysosome Biology, Twinning LYSOCIL, 2019.
  36. Luis Sousa; Gabriela Santos; João Martins; Angela Castela; Tiago F outeiro; Gabriela Araujo Silva; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Elucidating the role of synucleins in retinal neurodegeneration in Parkinson's disease, Diabetes and Ageing". Paper presented in Synuclein meeting, Porto, Portugal, 2019.
  37. Lopes-da-Silva, Mafalda; Ana S. Falcão; Cristina Escrevente; Inês Ferreira; Tenreiro, Sandra; Miguel C. Seabra. "Using CLEM to unravel intracellular membrane trafficking defects". Paper presented in Microscopy at the Frontiers of Science, 2019.
  38. Cristina Escrevente; Ana S. Falcão; Maria H. Cardoso; Inês Ferreira; Tenreiro, Sandra; Miguel C. Seabra. "Unravelling the role of lysosome dysfunction in the pathogenesis of age-related macular degeneration". Paper presented in LYSOCIL workshop, 2019.
  39. Carolina Nhacocane; Cristina Escrevente; Marta Nogueira; Carolina Piedade; Ines Ferreira; Maria H. Cardoso; Miguel Chaves-Ferreira; et al. "Dissecting the role of V-ATPase subunit isoforms on age-related macular degeneration". Paper presented in LYSOCIL workshop, Lisboa, Portugal, 2019.
  40. Miguel Mesquita; Pedro Antas; Inês Ferreira; Tenreiro, Sandra; Miguel C. Seabra. "Purification and characterization of dysfunctional lysosomes in chronic age related disease models". Paper presented in LYSOCIL workshop. Lisboa, Portugal, 2019.
  41. Miguel Chaves-Ferreira; Pedro Antas; Inês Ferreira; Tenreiro, Sandra; Miguel C. Seabra. "Mechanisms of cell death in Choroideremia". Paper presented in LYSOCIL workshop. Lisboa, Portugal, 2019.
  42. Luísa Lemos; ANTAS, PEDRO; Inês Ferreira; Miguel C. Seabra; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modeling retinal degenerative diseases with 3D-human retinal organoids.". Paper presented in 1st meeting on Ageing: models, mechanisms and therapies, 2019.
  43. Ana Sofia Falcão; Helena Cardoso; Michel Hall; Cristina Escrevente; ANTAS, PEDRO; Chaves-Ferreira, Miguel; Tenreiro, Sandra; Clare E. Futter; Miguel C. Seabra. "Exploring the role of lysosomal dysfunction in the pathogenesis of age-related macular degeneration". Paper presented in Ageing: Models, mechanisms and therapies, 2019.
  44. Tenreiro, Sandra; Cardoso, Maria Helena; Hall, Michael; Escrevente, Cristina; Falcão, Ana Sofia; ANTAS, PEDRO; Chaves-Ferreira, Miguel; et al. "Emerging insights on the pathogenesis of early age-related macular degenerationby modelling lysosome dysfunction". Paper presented in Nature Conference: Ageing, Health & Rejuvenation, 2019.
  45. Ana C. Fradinho; Maria H. Cardoso; F Montemurro; D Cuffaro; Elisa Nuti; A Rosselo; Carmelo De Maria; et al. "Bioengineered in vitro model of retinal pigment epithelium of the human eye". Paper presented in Ageing: Models, mechanisms and therapies, Coimbra, Portugal, 2019.
  46. Tenreiro, Sandra; Maria H. Cardoso; Michael Hall; Ana S. Falcão; Pedro Antas; Miguel Chaves-Ferreira; Clare E. Futter; Miguel C. Seabra. "Emerging insights on pathogenesis of early age-related macular degeneration by modelling lysosome dysfunction". Paper presented in Nature Conference: Ageing, Health & Rejuvenation, 2019.
  47. Tenreiro, Sandra; Cardoso, MH; Hall, Michael; Escrevente, Cristina; Falcão, Sofia; ANTAS, PEDRO; Chaves-Ferreira, Miguel; et al. "Lysosomal dysfunction in the retinal pigmented epithelium and the pathogenesis of age-related macular degeneration.". Paper presented in ARVO Conference 2019. Baltimore, USA, 2019.
  48. Andreia Silva; Joana Rodrigues; Outeiro, Tiago; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Dissecting the effect of aSyn familial mutations on aSyn fate and lysosomal dysfunction in a yeast model of Parkinson's disease". Paper presented in XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, 2019.
  49. Tenreiro, Sandra; Maria H. Cardoso; Michael Hall; Cristina Escrevente; Ana S. Falcão; Pedro Antas; Miguel Chaves-Ferreira; Ines Ferreira; Miguel C. Seabra. "Models of lysosomal dysfunction in retinal pigmented epithelium cells to study Age-related Macular Degeneration". Paper presented in COST Transautophagy: Annual Meeting. Sofia, Bulgaria, 2019.
  50. Michael HalI; Maria H. Cardoso; Ana S. Falcão; Cristina Escrevente; Tenreiro, Sandra; Miguel C. Seabra; Claire Futter. "Modelling lysosome dysfunction in the retinal pigment epithelium in the development of early Age-related Macular Degeneration". Paper presented in Gordon Research Conference on Lysosomal Diseases. Galveston, United States., 2019.
  51. Nhacocane, C; Escrevente, C; Nogueira, M; Piedade, C; Ferreira, Inês; Cardoso, MH; Chaves-Ferreira, M; et al. "Dissecting the role of V-ATPase subuni isoforms on age-related macular degeneration". Paper presented in LYSOCIL workshop, 2019.
  52. Halena M Cardoso; Cristina Escrevente; Ana S. Falcão; Gabriela Santos; Michael Hall; Ana C. Fradinho; Pedro Antas; et al. "A synergistic approach to rejuvenate the retina and promote elderly vision". Paper presented in NOVAsaúde Ageing, Lisboa, Portugal, 2018.
  53. Falcão, AS; Cardoso, MH; Escrevente, C; Santos, G; Tenreiro, S; Seabra, MC. "Lysosome dysfunction in the retinal pigment epithelium (RPE) and the pathogenesis of age-related macular degeneration (AMD)". Paper presented in CEDOC Symposium, Lisboa, Portugal, 2018.
Journal article
  1. Teixeira, João; Lumack do Monte, Zélia; Tenreiro, Sandra; Salema-Oom, Madalena; Silva, Diana C.; Saramago, Benilde; Paula Serro, Ana. Corresponding author: Silva, Diana C.. "Citicoline eluting hydrogels for therapeutic contact lenses intended to treat neurodegenerative diabetic ocular diseases". International Journal of Pharmaceutics 667 (2024): 124908. http://dx.doi.org/10.1016/j.ijpharm.2024.124908.
    Published
  2. Fonseca, Ana Fragoso; Coelho, Rita; Lopes-da-Silva, Mafalda; Lemos, Luísa; Hall, Michael James; Oliveira, Daniela; Falcão, Ana Sofia; et al. Corresponding author: Antas, Pedro. "Modeling Choroideremia disease with isogenic induced Pluripotent Stem Cells". Stem Cells and Development (2024): http://dx.doi.org/10.1089/scd.2024.0105.
    Published • 10.1089/scd.2024.0105
  3. de Lemos, Luisa; Antas, Pedro; Ferreira, Inês S.; Santos, Inês Paz; Felgueiras, Beatriz; Gomes, Catarina M.; Brito, Catarina; Seabra, Miguel C.; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids". In vitro models 3 1 (2024): 33-48. http://dx.doi.org/10.1007/s44164-024-00068-1.
    Open access • Published • 10.1007/s44164-024-00068-1
  4. Flores, Rita; Fradinho, Ana C.; Pereira, Rita Serras; Mendes, Jorge M.; Seabra, Miguel C.; Tenreiro, Sandra; Carneiro, Ângela. Corresponding author: Flores, Rita. "Identifying Imaging Predictors of Intermediate Age-Related Macular Degeneration Progression". Translational Vision Science & Technology 12 7 (2023): 22. http://dx.doi.org/10.1167/tvst.12.7.22.
    Open access • Published • 10.1167/tvst.12.7.22
  5. Dias, Sarah Batista; de Lemos, Luísa; Sousa, Luís; Bitoque, Diogo B.; Silva, Gabriela Araújo; Seabra, Miguel C.; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "Age-Related Changes of the Synucleins Profile in the Mouse Retina". Biomolecules 13 1 (2023): 180. http://dx.doi.org/10.3390/biom13010180.
    Open access • Published • 10.3390/biom13010180
  6. Cabral, Diogo; Ramtohul, Prithvi; Kaden, Talia R.; Tenreiro, Sandra; Seabra, Miguel C.; Freund, K. Bailey. Corresponding author: Freund, K. Bailey. "Hyperpigmented epiretinal membrane in macular telangiectasia type 2: imaging characteristics and correlation with transretinal pigment migration". Eye (2022): http://dx.doi.org/10.1038/s41433-022-02260-7.
    Published • 10.1038/s41433-022-02260-7
  7. Cabral, Diogo; Fradinho, Ana C.; Pereira, Telmo; Ramakrishnan, Meera S.; Bacci, Tommaso; An, Dong; Tenreiro, Sandra; et al. Corresponding author: Freund, K. Bailey. "Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography". Translational Vision Science & Technology 11 6 (2022): 2. http://dx.doi.org/10.1167/tvst.11.6.2.
    Open access • Published • 10.1167/tvst.11.6.2
  8. Flores, Rita; Carneiro, Ângela; Neri, Guilherme; Fradinho, Ana C.; Quenderra, Bruno; Barata, Maria João; Tenreiro, Sandra; Seabra, Miguel C.. Corresponding author: Flores, Rita. "Choroidal Vascular Impairment in Intermediate Age-Related Macular Degeneration". Diagnostics 12 5 (2022): 1290. http://dx.doi.org/10.3390/diagnostics12051290.
    Open access • Published • 10.3390/diagnostics12051290
  9. Flores, Rita; Carneiro, Ângela; Tenreiro, Sandra; Seabra, Miguel C.. Corresponding author: Flores, Rita. "Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration". Life 12 1 (2021): 36. http://dx.doi.org/10.3390/life12010036.
    Open access • Published • 10.3390/life12010036
  10. Escrevente, Cristina; Falcão, Ana S.; Hall, Michael J.; Lopes-da-Silva, Mafalda; Antas, Pedro; Mesquita, Miguel M.; Ferreira, Inês S.; et al. Corresponding author: Seabra, Miguel C.. "Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction". Investigative Opthalmology & Visual Science 62 9 (2021): 39. http://dx.doi.org/10.1167/iovs.62.9.39.
    Open access • Published • 10.1167/iovs.62.9.39
  11. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    Open access • Published • 10.1080/15548627.2020.1797280
  12. Ferreira, Carla; Couceiro, Joana; Tenreiro, Sandra; Quintas, Alexandre. Corresponding author: Quintas, Alexandre. "A biophysical perspective on the unexplored mechanisms driving Parkinson's disease by amphetamine-like stimulants". Neural Regeneration Research 16 11 (2021): 2213. http://dx.doi.org/10.4103/1673-5374.310675.
    Open access • Published • 10.4103/1673-5374.310675
  13. Flores, Rita; Carneiro, Ângela; Vieira, Miguel; Tenreiro, Sandra; Seabra, Miguel C.. Corresponding author: Flores, Rita. "Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives". Ophthalmologica 244 6 (2021): 495-511. http://dx.doi.org/10.1159/000517520.
    Open access • Published • 10.1159/000517520
  14. Flores, Rita; Carneiro, Angela; Serra, Joana; Gouveia, Nélia; Pereira, Telmo; Mendes, Jorge M.; Coelho, Pedro S.; Tenreiro, Sandra; Seabra, Miguel C.. Corresponding author: Flores, Rita. "Correlation study between Drusen morphology and Fundus Autofluorescence". Retina Publish Ah (2020): http://dx.doi.org/10.1097/iae.0000000000002881.
    Published • 10.1097/iae.0000000000002881
  15. Ferreira, Carla; Almeida, Catarina; Tenreiro, Sandra; Quintas, Alexandre. Corresponding author: Quintas, Alexandre. "Neuroprotection or Neurotoxicity of Illicit Drugs on Parkinson's Disease". Life 10 6 (2020): 86. http://dx.doi.org/10.3390/life10060086.
    Open access • Published • 10.3390/life10060086
  16. Fernández-Messina, Lola; Rodríguez-Galán, Ana; de Yébenes, Virginia G; Gutiérrez-Vázquez, Cristina; Tenreiro, Sandra; Seabra, Miguel C; Ramiro, Almudena R; Sánchez-Madrid, Francisco. Corresponding author: Sánchez-Madrid, Francisco. "Transfer of extracellular vesicle-micro RNA controls germinal center reaction and antibody production". EMBO reports 21 4 (2020): http://dx.doi.org/10.15252/embr.201948925.
    Published • 10.15252/embr.201948925
  17. Ferreira, Carla; Couceiro, Joana; Família, Carlos; Jardim, Carolina; Antas, Pedro; Santos, Cláudia N; Outeiro, Tiago F; Tenreiro, Sandra; Quintas, Alexandre. Corresponding author: Quintas, Alexandre. "The synthetic cannabinoid JWH-018 modulates Saccharomyces cerevisiae energetic metabolism". FEMS Yeast Research 19 5 (2019): http://dx.doi.org/10.1093/femsyr/foz042.
    Published • 10.1093/femsyr/foz042
  18. Brás, Inês Caldeira; Tenreiro, Sandra; Silva, Andreia M; Outeiro, Tiago F. Corresponding author: Outeiro, Tiago F. "Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast". FEMS Yeast Research 18 8 (2018): http://dx.doi.org/10.1093/femsyr/foy108.
    Published • 10.1093/femsyr/foy108
  19. Macedo, Diana; Jardim, Carolina; Figueira, Inês; Almeida, A. Filipa; McDougall, Gordon J.; Stewart, Derek; Yuste, Jose E.; et al. Corresponding author: Tenreiro, Sandra. "(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-25118-z.
    Open access • Published • 10.1038/s41598-018-25118-z
  20. Tenreiro, Sandra; Franssens, Vanessa; Winderickx, Joris; Outeiro, Tiago Fleming. Corresponding author: Outeiro, Tiago Fleming. "Yeast models of Parkinson's disease-associated molecular pathologies". Current Opinion in Genetics & Development 44 (2017): 74-83. http://dx.doi.org/10.1016/j.gde.2017.01.013.
    Published • 10.1016/j.gde.2017.01.013
  21. Macedo, Diana; Bertolin, Telma Elita; Oro, Tatiana; Hartmann Backes, Luana Tais; Bras, Ines Caldeira; Santos, Claudia Nunes; Tenreiro, Sandra; Outeiro, Tiago Fleming. "Phycocyanin protects against Alpha-Synuclein toxicity in yeast". Journal of Functional Foods (2017): https://publons.com/publon/8008033/.
    10.1016/J.JFF.2017.09.044
  22. Lázaro, Diana F.; Dias, Mariana Castro; Carija, Anita; Navarro, Susanna; Madaleno, Carolina Silva; Tenreiro, Sandra; Ventura, Salvador; Outeiro, Tiago F.. Corresponding author: Outeiro, Tiago F.. "The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation". Acta Neuropathologica Communications 4 1 (2016): http://dx.doi.org/10.1186/s40478-016-0402-8.
    Open access • 10.1186/s40478-016-0402-8
  23. Tenreiro, S.; Rosado-Ramos, R.; Gerhardt, E.; Favretto, F.; Magalhães, F.; Popova, B.; Becker, S.; et al. Corresponding author: Tenreiro, S.. "Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity". Human Molecular Genetics 25 2 (2016): 275-290. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960800242&partnerID=MN8TOARS.
    Published • 10.1093/hmg/ddv470
  24. Menezes, Regina; Tenreiro, Sandra; Macedo, Diana; Santos, Claudia; Outeiro, Tiago. Corresponding author: Outeiro, Tiago. "From the baker to the bedside: yeast models of Parkinson's disease". Microbial Cell 2 8 (2015): 262-279. http://dx.doi.org/10.15698/mic2015.08.219.
    Open access • Published • 10.15698/mic2015.08.219
  25. Mbefo, Martial Kamdem; Fares, Mohamed-Bilal; Paleologou, Katerina; Oueslati, Abid; Yin, Guowei; Tenreiro, Sandra; Pinto, Madalena; et al. Corresponding author: Lashuel, Hilal A.. "Parkinson Disease Mutant E46K Enhances a-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, andin Vivo". Journal of Biological Chemistry 290 15 (2015): 9412-9427. http://dx.doi.org/10.1074/jbc.m114.610774.
    Open access • Published • 10.1074/jbc.m114.610774
  26. Macedo, Diana; Tavares, Lucélia; McDougall, Gordon J.; Vicente Miranda, Hugo; Stewart, Derek; Ferreira, Ricardo B.; Tenreiro, Sandra; Outeiro, Tiago F.; Santos, Cláudia N.. Corresponding author: Tenreiro, Sandra. "(Poly)phenols protect from a-synuclein toxicity by reducing oxidative stress and promoting autophagy". Human Molecular Genetics 24 6 (2014): 1717-1732. http://dx.doi.org/10.1093/hmg/ddu585.
    Published • 10.1093/hmg/ddu585
  27. Zondler, L.; Miller-Fleming, L.; Repici, M.; Gonçalves, S.; Tenreiro, S.; Rosado-Ramos, R.; Betzer, C.; et al. Corresponding author: Outeiro, T. F.. "DJ-1 interactions with a-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease". Cell Death Dis 5 (2014): e1350-e1350.
    Open access • Published • 10.1038/cddis.2014.307
  28. Fernandes, João Tiago S.; Tenreiro, Sandra; Gameiro, Andreia; Chu, Virginia; Outeiro, Tiago F.; Conde, João P.. Corresponding author: Conde, João P.. "Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator". Lab Chip 14 20 (2014): 3949-3957. http://dx.doi.org/10.1039/c4lc00756e.
    Published • 10.1039/c4lc00756e
  29. Tenreiro, S.; Reimão-Pinto, M. M.; Antas, P.; Rino, J.; Wawrzycka, D.; Macedo, D.; Rosado-Ramos, R.; et al. Corresponding author: Tenreiro, S.. "Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease". PLoS Genet 10 5 (2014): e1004302-e1004302.
    Open access • Published • 10.1371/journal.pgen.1004302
  30. Tenreiro, S.; Eckermann, K.; Outeiro, T. F.. "Protein phosphorylation in neurodegeneration: friend or foe?". Front Mol Neurosci 7 (2014): 42-42.
    Open access • Published • 10.3389/fnmol.2014.00042
  31. Basso, Elisa; Antas, Pedro; Marijanovic, Zrinka; Gonçalves, Susana; Tenreiro, Sandra; Outeiro, Tiago Fleming. Corresponding author: Outeiro, Tiago Fleming. "PLK2 Modulates a-Synuclein Aggregation in Yeast and Mammalian Cells". Molecular Neurobiology 48 3 (2013): 854-862. http://dx.doi.org/10.1007/s12035-013-8473-z.
    Published • 10.1007/s12035-013-8473-z
  32. Tenreiro, Sandra; Munder, Matthias C.; Alberti, Simon; Outeiro, Tiago F.. "Harnessing the power of yeast to unravel the molecular basis of neurodegeneration". Journal of Neurochemistry 127 4 (2013): 438-452. http://dx.doi.org/10.1111/jnc.12271.
    Open access • Published • 10.1111/jnc.12271
  33. Faria, Cristiana; Jorge, Carla D; Borges, Nuno; Tenreiro, Sandra; Outeiro, Tiago F; Santos, Helena. "Inhibition of formation of alpha-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease.". Biochimica et biophysica acta 1830 8 (2013): 4065-72.
    Published • 10.1016/j.bbagen.2013.04.015
  34. Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Márcio; Tenreiro, Sandra; Franssens, Vanessa; Reichert, Andreas S.; et al. "SNCA (a-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy". Autophagy 8 10 (2012): 1494-1509. http://dx.doi.org/10.4161/auto.21275.
    Published • 10.4161/auto.21275
  35. Tenreiro, Sandra; Rosa, Patrícia; Chu, Virginia; Outeiro, Tiago F.; Conde, João Pedro. Corresponding author: Conde, João Pedro. "High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment". Biomicrofluidics 6 1 (2012): 014109. http://dx.doi.org/10.1063/1.3683161.
    Open access • Published • 10.1063/1.3683161
  36. de Oliveira, Rita Machado; Marijanovic, Zrinka; Carvalho, Filipe; Miltényi, Gabriel Miltenberger; Matos, Joana Estevão; Tenreiro, Sandra; Oliveira, Sónia; et al. "Impaired Proteostasis Contributes to Renal Tubular Dysgenesis". PLoS ONE 6 6 (2011): e20854. http://dx.doi.org/10.1371/journal.pone.0020854.
    Open access • Published • 10.1371/journal.pone.0020854
  37. Teixeira, Miguel C.; Cabrito, Tânia R.; Hanif, Zaitunnissa M.; Vargas, Rita C.; Tenreiro, Sandra; Sá-Correia, Isabel. "Yeast response and tolerance to polyamine toxicity involving the drug¿:¿H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4". Microbiology 157 4 (2011): 945-956. http://dx.doi.org/10.1099/mic.0.043661-0.
    Published • 10.1099/mic.0.043661-0
  38. Herrera, Federico; Tenreiro, Sandra; Miller-Fleming, Leonor; Outeiro, Tiago Fleming. "Visualization of cell-to-cell transmission of mutant huntingtin oligomers". PLoS Currents 3 (2011): RRN1210. http://dx.doi.org/10.1371/currents.rrn1210.
    Open access • Published • 10.1371/currents.rrn1210
  39. Tenreiro, Sandra; Outeiro, Tiago Fleming. "Simple is good: yeast models of neurodegeneration". FEMS Yeast Research 10 8 (2010): 970-979. http://dx.doi.org/10.1111/j.1567-1364.2010.00649.x.
    Open access • Published • 10.1111/j.1567-1364.2010.00649.x
  40. dos Santos, S. C.; Tenreiro, S.; Palma, M.; Becker, J.; Sa-Correia, I.. "Transcriptomic Profiling of the Saccharomyces cerevisiae Response to Quinine Reveals a Glucose Limitation Response Attributable to Drug-Induced Inhibition of Glucose Uptake". Antimicrobial Agents and Chemotherapy 53 12 (2009): 5213-5223. http://dx.doi.org/10.1128/aac.00794-09.
    Open access • Published • 10.1128/aac.00794-09
  41. Monteiro, P. T.; Mendes, N. D.; Teixeira, M. C.; d'Orey, S.; Tenreiro, S.; Mira, N. P.; Pais, H.; et al. "YEASTRACT-DISCOVERER: new tools to improve the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae". Nucleic Acids Research 36 Database (2007): D132-D136. http://dx.doi.org/10.1093/nar/gkm976.
    Open access • Published • 10.1093/nar/gkm976
  42. Vargas, Rita C.; García-Salcedo, Raúl; Tenreiro, Sandra; Teixeira, Miguel C.; Fernandes, Alexandra R.; Ramos, José; Sá-Correia, Isabel. Corresponding author: Sá-Correia, Isabel. "Saccharomyces cerevisiae Multidrug Resistance Transporter Qdr2 Is Implicated in Potassium Uptake, Providing a Physiological Advantage to Quinidine-Stressed Cells". Eukaryotic Cell 6 2 (2006): 134-142. http://dx.doi.org/10.1128/ec.00290-06.
    Open access • Published • 10.1128/ec.00290-06
  43. Alenquer, Marta; Tenreiro, Sandra; Sá-Correia, Isabel. "Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinantsTPO1andPDR5". FEMS Yeast Research 6 8 (2006): 1130-1139. http://dx.doi.org/10.1111/j.1567-1364.2006.00095.x.
    Open access • Published • 10.1111/j.1567-1364.2006.00095.x
  44. Teixeira, M. C.. "The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae". Nucleic Acids Research 34 90001 (2006): D446-D451. http://dx.doi.org/10.1093/nar/gkj013.
    Open access • Published • 10.1093/nar/gkj013
  45. Tenreiro, Sandra; Vargas, Rita C.; Teixeira, Miguel C.; Magnani, Charlène; Sá-Correia, Isabel. "The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin". Biochemical and Biophysical Research Communications 327 3 (2005): 952-959. http://dx.doi.org/10.1016/j.bbrc.2004.12.097.
    Published • 10.1016/j.bbrc.2004.12.097
  46. Velasco, Isabel; Tenreiro, Sandra; Calderon, Isabel L.; André, Bruno. "Saccharomyces cerevisiaeAqr1 Is an Internal-Membrane Transporter Involved in Excretion of Amino Acids". Eukaryotic Cell 3 6 (2004): 1492-1503. http://dx.doi.org/10.1128/ec.3.6.1492-1503.2004.
    Open access • Published • 10.1128/ec.3.6.1492-1503.2004
  47. Vargas, R. C.; Tenreiro, S.; Teixeira, M. C.; Fernandes, A. R.; Sa-Correia, I.. "Saccharomyces cerevisiae Multidrug Transporter Qdr2p (Yil121wp): Localization and Function as a Quinidine Resistance Determinant". Antimicrobial Agents and Chemotherapy 48 7 (2004): 2531-2537. http://dx.doi.org/10.1128/aac.48.7.2531-2537.2004.
    Open access • Published • 10.1128/aac.48.7.2531-2537.2004
  48. Felder, Thomas; Bogengruber, Edith; Tenreiro, Sandra; Ellinger, Adi; Sá-Correia, Isabel; Briza, Peter. "Dtr1p, a Multidrug Resistance Transporter of the Major Facilitator Superfamily, Plays an Essential Role in Spore Wall Maturation inSaccharomyces cerevisiae". Eukaryotic Cell 1 5 (2002): 799-810. http://dx.doi.org/10.1128/ec.1.5.799-810.2002.
    Open access • Published • 10.1128/ec.1.5.799-810.2002
  49. Sá-Correia, Isabel; Tenreiro, Sandra. "The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence". Journal of Biotechnology 98 2-3 (2002): 215-226. http://dx.doi.org/10.1016/s0168-1656(02)00133-5.
    Published • 10.1016/s0168-1656(02)00133-5
  50. Tenreiro, Sandra; Nunes, Patri´cia A; Viegas, Cristina A; Neves, Mónica S; Teixeira, Miguel C; Cabral, M.Guadalupe; Sá-Correia, Isabel. "AQR1 Gene (ORF YNL065w) Encodes a Plasma Membrane Transporter of the Major Facilitator Superfamily That Confers Resistance to Short-Chain Monocarboxylic Acids and Quinidine in Saccharomyces cerevisiae". Biochemical and Biophysical Research Communications 292 3 (2002): 741-748. http://dx.doi.org/10.1006/bbrc.2002.6703.
    Published • 10.1006/bbrc.2002.6703
  51. Nunes, P. A.; Tenreiro, S.; Sa-Correia, I.. "Resistance and Adaptation to Quinidine in Saccharomyces cerevisiae: Role of QDR1 (YIL120w), Encoding a Plasma Membrane Transporter of the Major Facilitator Superfamily Required for Multidrug Resistance". Antimicrobial Agents and Chemotherapy 45 5 (2001): 1528-1534. http://dx.doi.org/10.1128/aac.45.5.1528-1534.2001.
    Open access • Published • 10.1128/aac.45.5.1528-1534.2001
  52. Tenreiro, Sandra; Fernandes, Alexandra R.; Sá-Correia, Isabel. "Transcriptional Activation of FLR1 Gene during Saccharomyces cerevisiae Adaptation to Growth with Benomyl: Role of Yap1p and Pdr3p". Biochemical and Biophysical Research Communications 280 1 (2001): 216-222. http://dx.doi.org/10.1006/bbrc.2000.4100.
    Published • 10.1006/bbrc.2000.4100
  53. Tenreiro, Sandra; Rosa, Paula C.; Viegas, Cristina A.; S¿-Correia, Isabel. "Expression of the AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the major facilitator superfamily, is required for adaptation to acetic acid and resistance to azoles inSaccharomyces cerevisiae". Yeast 16 16 (2000): 1469-1481. http://dx.doi.org/10.1002/1097-0061(200012)16:16<1469::aid-yea640>3.0.co;2-a.
    Open access • Published • 10.1002/1097-0061(200012)16:16<1469::aid-yea640>3.0.co;2-a
  54. Brôco, Nuno; Tenreiro, Sandra; Viegas, Cristina A.; Sá-Correia, Isabel. "FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance inSaccharomyces cerevisiae and its benomyl-induced expression is dependent on Pdr3 transcriptional regulator". Yeast 15 15 (1999): 1595-1608. http://dx.doi.org/10.1002/(sici)1097-0061(199911)15:15<1595::aid-yea484>3.0.co;2-6.
    Open access • Published • 10.1002/(sici)1097-0061(199911)15:15<1595::aid-yea484>3.0.co;2-6
  55. TENREIRO, S.; NOBRE, M. F.; RAINEY, F. A.; MIGUEL, C.; DA COSTA, M. S.. "Thermonema rossianum sp. nov., a New Thermophilic and Slightly Halophilic Species from Saline Hot Springs in Naples, Italy". International Journal of Systematic Bacteriology 47 1 (1997): 122-126. http://dx.doi.org/10.1099/00207713-47-1-122.
    Published • 10.1099/00207713-47-1-122
  56. Nobre, M.F.; Carreto, L.; Wait, R.; Tenreiro, S.; Fernandes, O.; Sharp, R.J.; Da Costa, M.S.. "Fatty acid composition of the species of the genera Thermus and Meiothermus". Systematic and Applied Microbiology 19 3 (1996): 303-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029911483&partnerID=MN8TOARS.
  57. TENREIRO, S.; NOBRE, M. F.; DA COSTA, M. S.. "Thermus silvanus sp. nov. and Thermus chliarophilus sp. nov., Two New Species Related to Thermus ruber but with Lower Growth Temperatures". International Journal of Systematic Bacteriology 45 4 (1995): 633-639. http://dx.doi.org/10.1099/00207713-45-4-633.
    Published • 10.1099/00207713-45-4-633
  58. Tenreiro, S; Nobre, M.F; Hoste, B; Gillis, M; Kristjansson, J.K; Da Costa, M.S. "DNA:DNA hybridization and chemotaxonomic studies of Thermus scotoductus". Research in Microbiology 146 4 (1995): 315-324. http://dx.doi.org/10.1016/0923-2508(96)81054-0.
    Published • 10.1016/0923-2508(96)81054-0
  59. Ferraz, Ana Sofia; Carreto, Laura; Tenreiro, Sandra; Nobre, M. Fernanda; da Costa, Milton S.. "Polar lipids and fatty acid composition ofThermus strains from New Zealand". Antonie van Leeuwenhoek 66 4 (1994): 357-363. http://dx.doi.org/10.1007/bf00882773.
    Published • 10.1007/bf00882773
Magazine article
  1. Beatriz, Felgueiras; Tenreiro, Sandra; Fernandes, Rosa. Corresponding author: Fernandes, Rosa. "New Perspectives in Diabetic Retinopathy", Revista Portuguesa de Diabetes – Volume 19 – Nº 1, 2024, http://www.revportdiabetes.com/rpd-mar-2024/.
  2. Tenreiro, Sandra; Outeiro, Tiago Fleming. "A levedura como modelo para estudar as bases moleculares da doença de Parkinson", Revista Brasileira de Ciências do Envelhecimento Humano, 2015, http://seer.upf.br/index.php/rbceh/article/view/6006.
    10.5335/rbceh.v12i3.6006
Preprint
  1. Falcão, Ana S; Lopes-da-Silva, Mafalda; Antas, Pedro; Escrevente, Cristina; Pedro, Margarida; Coelho, Rita; Ferreira, Inês S; et al. "Enhancing lysosome function via mTOR/TFEB activation reduces lipofuscin-like granules in early Age-related Macular Degeneration". 2024. http://dx.doi.org/10.1101/2024.09.17.613413.
    10.1101/2024.09.17.613413
  2. de Lemos, Luisa; Antas, Pedro; Ferreira, Inês S.; Santos, Inês Paz; Gomes, Catarina M.; Brito, Catarina; Seabra, Miguel C.; Tenreiro, Sandra. Corresponding author: Tenreiro, Sandra. "3D human retinal organoid model for the study of early diabetic retinopathy". 2023. http://dx.doi.org/10.1101/2023.09.04.556258.
    10.1101/2023.09.04.556258
Thesis / Dissertation
  1. Tenreiro, Sandra. "Functional Analysis of new genes of saccharomyces cerevisiae encoding putative multidrug transporters from the major facilitator superfamily". PhD, Universidade de Lisboa Instituto Superior Técnico, 2001.
  2. Tenreiro, Sandra. "Isolation, characterization and description of two new species belonging to the genus Thermus". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1995.

Intellectual property

Patent
  1. Tenreiro, Sandra; de Lemos, Luísa; Miguel C. Seabra. 2022. "PATENT PENDING: A 3D cellular model of early Diabetic Retinopathy: PT118368 and EU 22217331.2 | TTNMS2202". Portugal.
    Pending
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/08/11 Advancing retinal disease models through retinal organoids MPS_NOVA Twinning kick-off meeting
MPS_NOVA Twinning (Oeiras, Portugal)
2024/05/05 Exploring human iPS cell-based alternatives to animal models - Challenges, hopes and future directions Encontro Ciência 2024
Fundação para a Ciência e a Tecnologia (Porto, Portugal)
2024/05/05 Modeling eye diseases: retinal organoids as a platform for studying degeneration and neuroinflammation NIMSB - NOVA Institute for Medical Systems Biology Seminars
NIMSB - NOVA Institute for Medical Systems Biology (Lisbon, Portugal)
2024/04/18 Harnessing NRF2: Bridging In Vitro and In Vivo Insights for Age-Related Macular Degeneration Therapy 7th BenBedPhar Scientific meeting
BenBedPhar COST ACTION (Tallinn, Estonia)
2023/11/23 Molecular mechanisms of AMD: exploring therapeutic strategies to early and intermediate states of the disease II Congreso Europeu de Pacientes Macula-Retina, Sevilla, Spain
Asociación Mácula Retina (Seville, Spain)
2023/09/28 Leadership in Research - A Diversity Perspective ICTER weekly Seminar
The International Centre for Translational Eye Research (ICTER) (Warsaw, Poland)
2023/09/07 Unlocking the potential of NRF2: an attractive approach to treat Age-Related Macular Degeneration BenBedPhar Open day (COST Action CA20121)
BenBedPhar COST Action CA20121 (Madrid, Lisbon, Dundee, Bucharest, Mainz, Spain)
2023/02/27 Exploring the role of extracellular vesicles as drug carriers and in intercellular communication in early diabetic retinopathy using a model of retinal organoids EVCA twinning Kick-off meeting, Ericeira, Portugal
Nova Medical School, UNL (Ericeira, Portugal)
2023/01/12 New models and tools to study retinal age associated diseases Biology of Ageing
Engineering in Medicine and Biology Society (Lisbon, Portugal)
2022/10/14 A repurposing strategy for Age-related Macular Degeneration targeting NRF2 BenBedPhar COST action Scientific meeting, Bucharest, Romania
"Vitor Babes" National institute of Pathology (Bucharest, Romania)
2022/09/27 Cell replacement therapies Reuniões Científicas de Oftalmologia 2022
Centro Hospitalar de São João (Porto, Portugal)
2022/07/26 Life of a Researcher II SCORE Symposium
Students Association from Nova Medical School (Lisbon, Portugal)
2022/05/20 Exploring NRF2 as a therapeutic target in early and intermediate age-related macular degeneration 2nd BenBedPhar Scientific meeting, Madrid, Spain
University of Madrid (Madrid, Spain)
2022/05/10 Challenges of preclinical research Cycle of seminars: May month of healthy vision
Universidade de Coimbra (Coimbra, Portugal)
2022/03/11 Development of a model of degeneration and inflammation by hyperglycaemia in retinal organoids 18 º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/06/18 Retinal Organoids for disease modelling 5th International Congress of CiiEM
Egas Moniz - Cooperativa de Ensino Superior, C.R.L. (Caparica, Portugal)
2018/10/19 Basic research fueling clinical studies for new therapeutic approaches XXVII Reunião de Oftalmologia do Centro Hospitalar de Lisboa Central, 1 as Jornadas de Investigação Translacional,
Sociedade Portuguesa de Oftalmologia (Lisboa, Portugal)
2018/07/10 Lysosomal dysfunction in the retinal pigmented ephithelium and the pathogenesis of age-related macular degeneration SMETS2- 2nd Small Meeting on Endocytic Trafficking and Signaling
(Braga, Portugal)
2017/10/27 SynDia: Synucleins - the link between Parkinson's disease and Diabetic Retinopathy? XXVI Reunião De Oftalmologia Do Centro Hospitalar de Lisboa Central
Sociedade Portuguesa de Oftalmologia (Lisbon, Portugal)
2014/08/27 Yeast as a model to study the molecular basis of Parkinson's disease International Congress of Human Aging studies
Universidade de Passo Fundo, Brazil (Passo Fundo, Brazil)
2014/06/11 Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease XX Jornadas de Biologia de Leveduras Nicolau van Uden
(Lisboa, Portugal)
2014/05/08 Neurodegenerative diseases XX Jornadas de Ciências Farmacêuticas
Instituto Superior de Ciências da Saúde Egas Moniz (Lisbon, Portugal)
2013/08/29 Harnessing the power of yeast to decifer the role of alfa-synuclein phosphorylation in Parkinson's disease 26th International Conference on Yeast Genetics and Molecular Biology
( Frakfurt, Germany)
2013/05/23 Yeast: a simple model to study the complexity of Parkinson’s disease Jornadas do centro de investigação CB3
Universidade Lusófona (Lisbon, Portugal)
2013/04/18 Yeast: a simple model to answer complex questions in Parkinson’s disease IV Jornadas de Ciências da Saúde
Instituto Superior de Ciências da Saúde Egas Moniz (Lisbon, Portugal)
2012/06/15 Using microfluidics for alpha-synuclein controlled expression and inclusions formation monitorization in a Parkinson's disease yeast model XIX Jornadas de Biologia de Leveduras Professor “Nicolau van Uden”
(Lisbon, Portugal)
2011/04/18 Simple is good: Yeast as a model to study Parkinson´s disease Lisbon Area of Neuroscience Meeting
Instituto de Medicina Molecular (Lisbon, Portugal)
2011/03/24 Simple is good: Yeast as a model to study neurodegenerative diseases Jornadas de Engenharia Química e Biológica 2011
Instituto superior Técnico (Lisbon, Portugal)
2010/06/18 Dissecting the role of alpha-synuclein phosphorylation in Parkinson’s disease: insights from a yeast model XVIII Jornadas de Biologia de Leveduras “Nicolau van Uden”
(Lisbon, Portugal)
2009/04/04 Yeast model and strategies form the pos-genomic era in the study of Parkinson’s disease JORTEC 2009. II Jornadas Tecnológicas da Licenciatura em Bioquímica
Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa (Lisbon, Portugal)
2008/06/06 Fom the wine to the brain: new model to study neurodegenerative diseases Conferência Genética molecular - Genes que ditam o nosso Quotidiano
Universidade Lusófona (Lisbon, Portugal)
2007/11/30 Mechanisms of resistance to quinidine and quinidine targets: post-genomic approaches using the eukaryotic model Saccharomyces cerevisiae MicroBiotec XXXIII JPG
(Lisbon, Portugal)
2006/12/08 The Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine stressed cells XVth National congress of Biochemistry
(Aveiro, Portugal)
2002/09/08 Antimalarial drug resistance: from yeast to Plasmodium Third European Congress on Tropical Medicine and International Health
(Lisbon, Portugal)
2001/12/05 Functional analysis of new S. cerevisiae genes encoding putative multidrug transporters from the major facilitator superfamily MICRO’2001
(Póvoa de Varzim, Portugal)
1999/05/21 Functional analysis of new S. cerevisiae genes encoding putative membrane transporters with homology to the major facilitator superfamily and involved in multidrug resistance 7as Jornadas de Biologia de Leveduras Professor Nicolau van Uden

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2024/09/01 - Current Therapeutic contact lenses for early/intermediate Age-related Macular Degeneration - 2024.02715.BD
Supervisor of Rita Isabel Martins Pais
PhD in Health Sciences (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/09/01 - Current Development of a lesion model in retinal organoids: exploring Müller glia regenerative role
Supervisor of Daniel Pereira
MSc in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09/01 - Current Imaging tools for automatic biomarkers analysis to evaluate progression in intermediate Age-related Macular Degeneration
Co-supervisor of Vasilii Lashkov
Master Thesis in Biomedical Research (Master)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/09/01 - Current The role of extracellular vesicles in the progression of diabetic retinopathy through the gut-liver-retina axis - 2023.02154.BD
Co-supervisor of Luana Macedo
PhD in Health Sciences (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/01 - Current Exploring a human retinal organoid model of early DiabeticRetinopathy for drug discovery - 2022.14250.BD
Supervisor of Maria Beatriz Ribeiro Felgueiras
International Doctoral Programme in Health Sciences (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/06/01 - Current Implementation of an Eye Biobank at NMS-UNL
Co-supervisor of Pedro Camacho
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/01 - 2024/11/13 Modelling retinal degenerative mechanisms and exploring novel neuroprotective therapies using 3D organoids
Supervisor of Olga Isabel Pires Almeida Spencer Carreira
MSc in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09/01 - 2024/10/31 Testing new NRF2 activators in an AMD mouse model
Co-supervisor of Shuvajit Rakshit
Master Thesis in Biomedical Research (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/03/01 - 2024/08/31 Modelling retinal neurodegeneration using a genetic model of synucleinopathy based on retinal organoids
Supervisor of Olga Carreira
Research assistant (iNOVA4Health grant SAI/2023/20) (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/03/01 - 2024/06/30 Modeling retinal diseases using organoids differentiated from human iPS cells
Supervisor of Alexandre Poulain
Guided Study in Organismal Biology and Evolution Course, BSc in Biology (Scientific initiation)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2024/03/01 - 2024/06/30 Modeling retinal diseases using organoids differentiated from human iPS cells
Supervisor of Maria Borges
Guided Study in Organismal Biology and Evolution Course, BSc in Biology (Scientific initiation)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2024/05/02 - 2024/05/17 Exploring retinal organoids as models to study retinal neurodegeneration
Supervisor of Angelo Rosado
Master in Biomedical Research (Lab rotation) (Scientific initiation)
Universidade de Coimbra Faculdade de Medicina, Portugal
2018/07 - 2024/03/25 Advancements in Medical Imaging Tools and Machine Learning Analysis to Improve Biomarkers of Age-Related Macular Degeneration
Co-supervisor of Ana Carolina Mourão Fradinho
PhD in Biomedicine (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/02/19 - 2024/03/15 New skills on in vivo and in vitro retinal disease models
Supervisor of Francisco Molina
Erasmus+ Student Mobility for Traineeships (PhD) (Specialization course)
Masarykova univerzita Biologický ústav, Czech Republic
2022/09/15 - 2023/12/31 Development of a Graphical User Interface for both research and clinical use in Dry Age-related Macular Degeneration
Co-supervisor of Ilaria Unali
Erasmus+ Student Mobility for Traineeships (Master) (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/01 - 2023/12/05 Development of a screening pipeline to identify modulators of Nrf2 activity
Supervisor of Margarida Pedro
MSc in Biochemistry for Health (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09/01 - 2023/11/30 Profile of age-related changes in mouse retina
Supervisor of Lisa Billwein
Erasmus+ Student Mobility for Traineeships (BSc) (Scientific initiation)
Fachhochschule Campus Wien, Austria
2019/09/01 - 2023/10/31 Implementation of an Ex vivo retinal organotipic culture model to study Age-Related Macular Degeneration
Supervisor of Zélia Dalla Nora Macedo Lumack do Monte
MSc in BiotechnologY (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/03/01 - 2023/07/11 Development of a co-culture in vitro system of retinal pigmented epithelium and neuroretina
Supervisor of Catarina Pfulb
BSc in Biochemistry (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/03/13 - 2023/05/31 2D and 3D cellular models of retinal diseases
Supervisor of Sara Daniela Teixeira Monteiro
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023/04/17 - 2023/05/28 Effects of Polyphenol on Mice Retina
Supervisor of Shuvajit Rakshit
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/03 - 2023/04 Image analysis in choroideremia patient cells
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/02/15 - 2023/03/15 Analysis of the ocular microvascular structure in patients with coarctation of the aorta by OCT-A image analysis
Co-supervisor of Carolina da Costa Abreu
Universidade Nova de Lisboa Departamento de Física, Portugal
2018/10/01 - 2023/02/22 Novel Psychoactive Substances and Parkinson's Disease: Molecular and cellular mechanisms of alpha-synuclein aggregation in the presence of synthetic cannabinoids and cathinones
Co-supervisor of Carla Filipa Silva Ferreira
PhD in Forensic Sciences (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2021/09/01 - 2022/12/07 Evaluating the effects of synthetic cannabinoids on neuronal development - an organoid- based model for pre-natal exposure
Co-supervisor of Rita Covas Gomes
MSc in Laboratory Technologies in Forensic Science, IUEM (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/02 - 2022/07 Molecular mechanisms envolved in Retina chronic diseases
Supervisor of Álvaro Basílio Fama
Integrated Master Degree in Medicine (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/02/15 - 2022/03/31 Recovering neuronal function and promoting neuroprotection in diabetic retinopathy
Supervisor of Maria Luisa de Lemos Machado
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/09/01 - 2021/04/30 Effects of Ageing in Retinal Degeneration and synuclein profile in mice
Co-supervisor of Sarah Dias
Nova Biomedical Research MSc (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/01/01 - 2021/03/31 Lysosome Dysfunction in Age-Related Diseases
Supervisor of Carolina Piedade
Research assistant - FCT Project PTDC/MED-PAT/30385/2017 (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/01/01 - 2020/11/15 Mechanisms of Cell Death in Choroideremia
Supervisor of Inês Sofia dos Santos Rodrigues Ferreira
Research assistant - Funded by Choroideremia Research Foundation (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/06 - 2020/06 Design and fabrication of a novel 3D in vitro model of the blood-retinal barrier
Co-supervisor of Guglielmo Pacetta
MSc in Biomedical Engineering (Master)
Universitá Di Pisa - Department of Information Engineering, Italy
2017/05/01 - 2019/12/01 Correction of lysosomal dysfunction in Retinal Pigmented Epithelial (RPE) cells (Boehringer Ingelheim funded project)
Co-supervisor of Ana Sofia Falcão
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09 - 2019/09 Elucidating the role of synucleins in retinal neurodegeneration in Parkinson's Disease, Diabetes and Ageing
Supervisor of Luís Miguel Antunes de Sousa
MSc in Biochemistry for Health (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/06/01 - 2019/08/31 Recovering Lysosome Function on Retinal pigmented epithelium
Supervisor of Joanna Sadlak
Erasmus+ Student Mobility for Traineeships (Master) (17 ECTs) (Scientific initiation)
Uniwersytet Wroclawski, Poland

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/07/01 - 2018/07/31 Lysosome dysfunction in age-related macular degeneration. Department of Medicine, Ioannina, Greece
Supervisor of Gkalapis Nikolaos
STANDING COMMITTEE ON RESEARCH EXCHANGE. International Federation of Medical Students' Associations. (Scientific initiation)
2018/01/01 - 2018/06/30 Characterization of V-ATPase isoforms expressed in the Retinal pigment epithelia in human retina
Supervisor of Marta Faro Craveiro Nogueira
Molecular and Cellular Biology Project, BSc in Cellular and Molecular Biology (Scientific initiation)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/10/01 - 2017/12/31 SynDia: Synucleins - the link between Parkinson's disease and Diabetic Retinopathy?
Supervisor of Angela Castela
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/09 - 2017/12 Bringing light to darkness: What is the role of synucleins in retinal neurodegeneration?
Supervisor of Gabriela Santos
MSc in Molecular Biotechnology (Master)
Universidade de Aveiro, Portugal
2016/09 - 2017/10 Dissecting the role of alpha-synuclein phosphorylation in Parkinson's Disease
Supervisor of Joana Rodrigues
MSc in Molecular Genetics and Biomedicine (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/01/01 - 2017/09/30 SynDia: Synucleins - the link between Parkinson’s disease and Diabetic Retinopathy?
Supervisor of João Martins
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/09 - 2017/03 Alpha-synuclein phosphorylation role on Parkinson's disease
Supervisor of Carolina Madaleno
MSc in Biochemistry (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015/09 - 2016/10 Molecular insights into the role of alpha-synuclein phosphorylation in synucleinopathies
Co-supervisor of Inês Brás
MSc in Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016/04/01 - 2016/09/30 SynDia: Synucleins - the link between Parkinson’s disease and Diabetic Retinopathy
Co-supervisor of Sofia de Amaral Melo Calado
Post-Doc (Other)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/01/01 - 2016/03/31 Dissecting the role of alpha-synuclein phosphorylation in Parkinson's disease
Supervisor of Viktor Scheidt
Short-term scientific mission COST-STSM-BM1307-29968 from the COST ACTION BM1307 PROTEOSTASIS (Specialization course)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011/04 - 2015/11 Investigating the neuroprotective effect of plant polyphenols in models of Parkinson's disease
Co-supervisor of Diana Leonor Constantino Macedo
PhD in Neurosciences (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2013/02/01 - 2015/06/30 The role and regulation of alpha-synuclein phosphorylation in both pathological and physiological conditions
Supervisor of Rita João Ramos
Research assistant - Funded by FCT project PTDC/BIA-BCM/117975/2010 (Other)
Instituto de Medicina Molecular, Portugal
2013/09 - 2015/06 Polyphenols neuroprotective effect in a Parkinson's disease yeast model: phosphoproteome alterations
Co-supervisor of Victor Gonçalves
MSc in Biomedical Sciences (Master)
Universidade do Algarve, Portugal
2013/09 - 2014/11 Metabolic pathways of JWH-018, JWH-073 e JWH-250 in Saccharomyces cerevisae
Co-supervisor of Carla Ferreira
MSc in Biomedical Sciences (Master)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01 - 2014/11 Alpha-synuclein phosphorylation: role and regulation
Co-supervisor of Elisa Basso
PhD in Neurosciences (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2012/10 - 2013/12 Alpha-synuclein phosphorylation role on Parkinson's disease
Co-supervisor of Filipa Magalhães Silva
MSc in Molecular Biology and Genetics (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/01 - 2013/09 Microfluidic Systems for Studies in Parkinson's Disease
Co-supervisor of Andreia Pereira Gameiro
MSc in Bioengineering and Nanosistems (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/02/01 - 2013/02/28 The role and regulation of alpha-synuclein phosphorylation in both pathological and physiological conditions
Supervisor of Madalena Reimão-Pinto
Research assistant - Funded by FCT project PTDC/BIA-BCM/117975/2010
Instituto de Medicina Molecular, Portugal
2012/01/01 - 2012/05/31 Academic-Industrial Initial Training Network (ITN) on Alpha-Synuclein Related Brain Diseases
Co-supervisor of Pedro Antas
Research assistant - Funded by European project FP7 NEURASYNC (Other)
Instituto de Medicina Molecular, Portugal
2010/09/01 - 2011/08/31 Academic-Industrial Initial Training Network (ITN) on Alpha-Synuclein Related Brain Diseases
Supervisor of Dina Hernandez
Research assistant - Funded by European project FP7 NEURASYNC (Other)
Instituto de Medicina Molecular, Portugal
2009/10 - 2010/06 Microfluidic Devices: Gradient Generation and Control of Local Cellular Environment for Biomedical Applications
Co-supervisor of Patrícia Moura Rosa
MSc in Biological Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/10 - 2009/09 Unraveling the role of alpha-synuclein in the etiology of Parkinson's disease
Co-supervisor of Olga Sin
MSc in Neurosciences (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2008/03 - 2008/09 Microfluidic Devices for single-cell analysis and gradient generation
Co-supervisor of Marta Amaral
MSc in Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/02/01 - 2007/06 Functional analysis of putative multidrug transporters from Plasmodium by heterologous expression in Saccharomyces cerevisiae
Co-supervisor of Nicole Mendes Inácio
Scientific traineeship, Molecular and Cellular Biology Degree (Scientific initiation)
Universidade Nova de Lisboa, Portugal
2003/02/01 - 2003/12/31 Antimalarial drug resistance: from yeast to Plasmodium
Co-supervisor of Joana Camilo
BSC in Biological Engineering (Scientific initiation)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1999/02/01 - 1999/06/30 Deletion and cloning of the S. cerevisiae ORF YIL121w
Co-supervisor of Rita Criner Vargas
Chemical Engineering (Scientific initiation)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1999/02/01 - 1999/06/30 Deletion and cloning of the S. cerevisiae ORF YIL120w
Co-supervisor of Rute Nelhas
Chemical Engineering (Scientific initiation)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2020/10/17 - Current Retina Interest Group (RIG) Virtual Meetings - This event aims to increase collaboration between ophthalmology clinicians and NMS-UNL research groups working on Vision related diseases. (organized 2 times per year) (2020/10/17)
Meeting (Co-organisor)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/10/10 - 2024/10/11 8th BenBedPhar MC and Scientific Meeting - Thirty years since the discovery of NRF2 Two days event from COST Action CA20121with 80 participants (2024/10/10 - 2024/10/11)
Meeting (President of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/09/27 - 2024/09/27 WORLD RETINA DAY: towards patient-centered research NOVA Medical School event to celebrate the World Retina Day dedicated to patients, bringing together patient associations, researchers and ophthalmologists. The art exhibition “Creative eye: visions beyond the visible” was also inaugurated. https://www.nms.unl.pt/en-us/faculty/news-and-events/events/detalhe/eventid/14245 (2024/09/27 - 2024/09/27)
Meeting (President of the Organising Committee)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/11/17 - 2023/11/20 EMBO Workshop on Proteostasis: From translation to degradation; Ericeira, Portugal (2022/08/01 - 2023/11/20)
Congress (Member of the Organising Committee)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2023/05/04 - 2023/05/04 LS4Future Retina & Vision meeting Meeting from the Research groups working from LS4Future on retina (2023/05/04 - 2023/05/04)
Meeting (Co-organisor)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2021/09/01 - 2022/07/31 NMS Casual Friday Seminars for internal speakers and Special Seminars with Science related up-to date thematic (weekly) (2021/09 - 2022/07/31)
Seminar (Co-organisor)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/11/23 - 2021/11/26 MICROBIOTEC'21 Congress of Microbiology and Biotechnology 2021 Biannual event co-organized by the Portuguese Society of Microbiology and the Portuguese Society of Biotechnology (2021/11/23 - 2021/11/26)
Congress (Member of the Organising Committee)
Universidade Nova de Lisboa, Portugal
2019/09/01 - 2019/09/04 Synuclein Meeting 2019: Where we are and where we need to go", Porto, Portugal LOCAL ORGANIZING COMMITTEE (2019/09/01 - 2019/09/04)
Congress (Member of the Organising Committee)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/01/30 - 2024/02/01 Chaperone Leadership Course by Sandrine Soubes (Leadership Course specifically designed for Young PIs organized by LS4Future (14h)
Workshop
Chaperone Leadership Course
2017/01/30 - 2017/01/31 Developing supervisory skills Course - Nova Doctoral School (12 hours)
Workshop
Developing supervisory skills Course
Universidade Nova de Lisboa, Portugal
2016 - 2016 Introduction to R Software and RStudio for Statistical analysis, by Regina Bispo, StartFactor, Statistical Consulting and Training (12 horas)
Workshop
Introduction to R Software and RStudio for Statistical analysis
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2013 - 2013 Grant writing workshop, by Dr. Judith Swan (Princeton University, USA) (8 Hours)
Workshop
Grant writing workshop
2010 - 2010 Course on Quantitative Light Microscopy in Living Cells Harvard Medical School - Portugal Program in Translational Research and Information (45 hours).
Workshop
Course on Quantitative Light Microscopy in Living Cells
Instituto de Medicina Molecular, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/03/13 LRRK2 Mutations in Parkinson’s disease: The Role in Autophagy and Lysosomal Function
(Thesis) Main arguer
Marta Madureira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/05/30 A cell-type specific selection system for stem cell therapy (and other) purposes
(Thesis) Arguer
Duarte Pólvora Brandão (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/05/19 Cross-regulation of mitochondrial function and cell cycle progression in budding yeast
(Thesis) Main arguer
Ana Cláudia Leite (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/01/26 Lysosome dysfunction, the link between aging and Alzheimer’s disease?
(Thesis) Arguer
Tatiana Marisa Andrade Burrinha (PhD)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/03/29 The role of cell signalling during yeast chronological lifespan
(Thesis) Main arguer
Hélder Ricardo Cardoso Pereira (PhD)
Universidade do Minho Escola de Medicina, Portugal
2022/02/08 Heterologous expression of mammalian phospholipase D1 and D2 in the yeast model
(Thesis) Main arguer
Inês Paula Ribeiro (Master)
Universidade do Minho Escola de Ciências, Portugal
2021/03/15 Generation of molecular tools for the expression and trafficking analyses of Human Monocarboxylate transporters
(Thesis) Main arguer
Diogo Martins Lopes (Master)
Universidade do Minho Escola de Ciências, Portugal
2020/12/21 Tears Biomarkers for Diagnosis Strategy of Diabetic Retinopathy Onset
(Thesis) Main arguer
Madania Gafur Amorim (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/16 Unveiling the role of deubiquitylating enzymes in plasma membrane repair
(Thesis) Main arguer
Maria de Vasconcelos Cardoso (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2017/12 Neuroprotective effects of TUDCA in Parkinson's disease: Dissecting the anti-oxidant and anti-inflammatory effects of this bile acid in the mouse cerebral cortex
(Thesis) Main arguer
Mariana Mendes (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/06/08 The role of ceramides in the mitochondrial apoptotic pathway induced by acetic acid
(Thesis) Main arguer
António Miguel Araújo Rego (PhD)
Universidade do Minho Escola de Ciências, Portugal
2016/01 Development of a new cellular model for the visualization and study of GFAP oligomerization in living cells
(Thesis) Main arguer
Ricardo Varela (Master)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015/12/16 Functional and genetic analysis of alpha-synuclein and huntingtin in Drosophila melanogaster
(Thesis) Main arguer
Gonçalo Poças (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/06 Engineering of Fatty Acid Production and Secretion in Saccharomyces cerevisiae
(Thesis) Arguer
Gabriela Filipa Lopes Ribeiro (PhD)
Universidade do Minho Escola de Ciências, Portugal
2014/07 Unravelling the molecular basis of a-Synuclein toxicity in yeast using a microfluidic structure with integrated photodiodes
(Thesis) Main arguer
Catarina Pedrosa (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/09 Role of the multidrug efflux pumps CgAqr1 and CgTpo2/3 in C. glabrata resistance to flucytosine and azole drugs André Sales Henriques (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/06 Involvement of the gene CaRLM1 in Candida albicans virulence
(Thesis) Main arguer
Yolanda Bedsabé Delgado Silva (PhD)
Universidade do Minho Escola de Ciências, Portugal
2011/03 Polyglutamine diseases (PolyQ): construction and characterization of yeast models
(Thesis) Main arguer
Patrícia Sofia Sousa Dias (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2006/06 Characterization of monocarboxylate permeases in yeast – functional and structural analysis
(Thesis) Main arguer
Isabel João Soares da Silva (PhD)
Universidade do Minho Escola de Ciências, Portugal
2006/01 Functional analysis of carboxylic acid permeases from Kluyveromyces lactis
(Thesis) Main arguer
Maria Leonor Gonçalves Pereira (Master)
Universidade do Minho Escola de Ciências, Portugal

Association member

Society Organization name Role
2024/03/01 - Current International Microphysiological Systems Society Inaugural member of the Society
2022/01/01 - Current Sociedade Portuguesa de Diabetologia Member
2020/02/01 - Current European Network for Pre-Clinical and Translational Eye Research Member
2017/07/01 - Current Portuguese Network on Extracellular Vesicles Member
2017/01/01 - Current Portuguese Society for Neuroscience (SPN) Member
2022/01/01 - 2022/12/31 European Association for the Study of Diabetes (EASD) Member

Committee member

Activity description
Role
Institution / Organization
2024/04/01 - Current PhD THESIS COMMITTEE: Inês Sofia da Silva Ferreira Supervisor: Otília Vieira, NMS-UNL
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/12/15 - Current ORBEA MEMBER - Commission Responsible for the Welfare of NMS Laboratory Animals
Member
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/12/01 - Current CO-COORDINATOR - NOVAsaúde - Ageing strategic area NOVA Ageing group is committed to increase research, knowledge and innovation in the field of aging and related conditions, towards an active and healthy aging. https://www.unl.pt/novasaude/ageing
Coordinator
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/11/16 - Current PhD THESIS COMMITTEE: Elizeth Lopes Supervisors: Otília Vieira, NMS-UNL
Member
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/11/01 - Current Green Labs Team to develop a sustainability culture in NMS laboratories
Member
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2022/12/12 - Current PhD THESIS COMMITTEE: Leslie Ann Silva Amaral - A humanized yeast model system to assess the risk of environmental pollutants to Parkinson's disease progression; Supervisors: Manuela Côrte-Real, Susana Chaves, Tiago Outeiro
Member
Universidade do Minho Escola de Ciências, Portugal
2021/07/16 - Current MANAGEMENT COMMITTEE MEMBER - European Action COST BenBedPhar - " Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases" (CA20121).
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/01/01 - Current PhD THESIS COMMITTEE: Fernanda Ivanira Henriques Murtinheira Ferreira "Towards a smaller but functional sacsin protein for ARSACS gene therapy", MolBioS PhD Program, Supervisor: Professor Federico Herrera (FCUL)
Member
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/05 - 2022/02/25 PhD THESIS COMMITTEE: Marcelo Mendonça, "Substantia Nigra in Parkinson's Disease: function and vulnerability", PhD in Medicine. Supervisors: Rui Costa (Fundação Champalimaud) and Paulo Bugalho (NMS-UNL)
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015/09 - 2021/01/31 PhD THESIS COMMITTEE: Marie Bordone, "The transcriptional landscape of Parkinson's disease" , PhD in Neurosciences, Supervisors: Nuno Morais and Sérgio de Almeida (iMM)
Member
Universidade de Lisboa Faculdade de Medicina, Portugal
2016/05/09 - 2020/04/21 MANAGEMENT COMMITTEE MEMBER (substitute): European Action COST CA15138 TRANSAUTOPHAGY -"European network for multidisciplinary research and translation of autophagy knowledge" More details: http://cost-transautophagy.eu/
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2019 PhD THESIS COMMITTEE: Pedro Dionísio, "Inflammation and Neuronal Demise in Neurodegenerative Diseases", PhD in Pharmacy, Supervisors: Joana D. Amaral (FFUC), Cecília M. P. Rodrigues (FFUC) and Tiago F. Outeiro (iMM)
Member
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/04/23 - 2018/04/24 MANAGEMENT COMMITTEE MEMBER (substitute): European Action COST BM1307 - European network to integrate research on intracellular proteolysis pathways in health and disease (PROTEOSTASIS)
Member
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Conference scientific committee

Conference name Conference host
2019/05/30 - 2019/06/01 XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, CEDOC and IMM, Lisbon, Portugal
2016/11/02 - 2016/11/05 3rd Proteostasis Action Meeting CEDOC, NMS-UNL, Lisbon, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09/01 - Current “New Cellular and Molecular therapies” Curricular unit (3 ECTs) International Doctoral Programme in Health Sciences (Postgraduate Certificate) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09/01 - Current "In Vitro Models: alternatives to animal models in research" Advanced Course (3 ECTs) Post graduation (Postgraduate Certificate) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/01 - Current Theoretical classes in " Chronic Diseases and Aging", "Rare Diseases And Neurodegeneration" courses PhD in Life Sciences Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/09 - Current Theoretical classes in "Cellular Regulation", " Critical Skills", "Neurosciences", " Advanced Research Methods" and "Seminar" courses NOVA BIOMEDICAL RESEARCH MSc degree Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/11/06 - 2023/11/17 Postgraduate course Cell and Molecular Mechanisms of Aging and Associated Diseases (Pós-Graduação) Universidade NOVA de Lisboa NOVA Medical School, Portugal
2023/09/01 - 2023/09/01 Molecular mechanisms of aging CONNECT Training School - CA 19127 (Postgraduate Certificate)
2022/11/28 - 2022/12/13 EIT Health Advanced Course: Cell and Molecular Mechanisms of Aging and Associated Diseases (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/03/25 - 2022/03/25 Course on "Translational Research: Practical Applications", Clinical Research Department Post-Graduation Course (Outros) Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Portugal
2021/03/08 - 2021/03/12 Advanced Course in Vision Sciences (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/09/01 - 2018/11/30 Theoretical and Practical Classes on Neurodegenerative disorders Molecular Mechanisms of Disease (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/06/23 - 2017/06/23 Synucleins: the link between Parkinson´s disease and diabetic retinopathy Translational Course for Clinicians Centro Hospitalar de Lisboa Central EPE, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2024/04/16 - 2024/04/16 POSTERS EVALUATOR - AIMS Meeting: Annual International (bio)Medical Students Meeting
Evaluator
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/10/01 - 2023/10/25 GRANT EVALUATOR - Targeted Call 2022 from the Swiss 3R Competence Centre, Switzerland. (International)
Evaluator
Swiss 3R Competence Centre, Switzerland Swiss 3R Competence Centre
2022/02/01 - 2022/10/15 FCT Evaluation committee of Exceptional Grants for Mitigating the Impacts of COVID-19 on Research Activities (PhD grants) / Comissão de Avaliação de Bolsas Excecionais de Mitigação de Impactos da COVID-19 nas Atividades de Investigação (Boldas de Doutoramento)
Evaluator
Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2021/09 - 2021/09 ABSTRACTS EVALUATOR - iMed Conference for Medicine and Life Sciences' Students in Europe
Evaluator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/09 - 2021/09 GRANT EVALUATOR - PEPITA Program FMUC & Santander-Totta
Evaluator
Universidade de Coimbra Faculdade de Medicina, Portugal Universidade de Coimbra Faculdade de Medicina

Banco Santander Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/10/15 "Advances in retinal disease research: NOVA Medical School bets on early diagnosis and new therapies". Interview for News Farma is a platform of communication for the Health sector. News Farma
2017/11/14 “Spirulina” tested to slow Parkinson’s disease", an article reporting our publication describing the effects of "Spirulina" delaying Parkinson's Disease. News Farma is a platform of communication for the Health sector. News Farma

Interview (tv / radio show)

Program Topic
2023/03/23 - 2023/03/23 90 Segundos de Ciência - Radio/Podcast Science Communication

Journal scientific committee

Journal title (ISSN) Publisher
2016 - Current Frontiers in Neuroscience (Review Editor) (1662-453X) Frontiers
2016 - Current Frontiers in Molecular Neuroscience (Review Editor) (1662-5099) Frontiers

Mentoring / Tutoring

Topic Student name
2022/11/01 - 2023/07/31 Gulbenkian New Talents Scholarship 2022 Vicente Lopes Miguel
2009/09/01 - 2021/07/01 The role of nuclear-encoded gene MPV17 in mtDNA maintenance (PhD student) Sandra Jacinto, MD
2009/03/01 - 2013/12/01 Structure and mechanism of Kynurenine 3-monooxygenase, a candidate Huntington disease drug target (PhD student) Marta Amaral

Other jury / evaluation

Activity description Institution / Organization
2023/11/08 - 2023/11/08 Evaluation of the project "The effects of sweeteners on cellular ageing" from the student Conceição Maria Santiago Nunes Gonçalves, under the UC "Transition to professional practice" from the MSc in Medicine Universidade do Minho Escola de Medicina, Portugal
Distinctions

Award

2022 Charneco da Costa Grant (5Keuros) - Exploring a human retinal organoid model of early Diabetic Retinopathy for drug discovery
Sociedade Portuguesa de Diabetologia, Portugal
2015 Postdoc fellowship (SFRH/BPD/101646/2014)
Fundação para a Ciência e a Tecnologia, Portugal
2010 Postdoc Fellowship - MEFOPA "Mendelian Forms of Parkinson's Disease 01/10/2010 - 30/09/2011
2008 Postdoc fellowship (SFRH/BPD/35767/2007) 01/02/2008-30/09/2010 and 01/10/2011-31/01/2015
Fundação para a Ciência e a Tecnologia, Portugal
2001 Postdoc fellowship (BPD/5649/2001)
Fundação para a Ciência e a Tecnologia, Portugal
1996 PhD Grant (BD/9633/96)
Fundação para a Ciência e a Tecnologia, Portugal
1993 MSc grant funded by Biotechnology of Extremophiles, Project (BIO2-CT93-0274)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Other distinction

2021 Editor's Choice as the 2020 Best paper from Life Journal
2019 Top Altmetric Scoring Article and Paper Marked as Editor's Choice