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Natanael Filipe Ferreira Fernandes is a PhD student in Biomedicine from University of Beira Interior (UBI). He obtained his BSc (score: 13 out of 20; 2018) and MSc (score: 17 out of 20; 2020) degrees in Biochemistry from UBI. In 2022, he was awarded with a Santander Totta/UBI scholarship (5 months) followed by a PhD fellowship from FCT in October of 2022. So far, Natanael Fernandes published 9 articles (2 as first author and 7 as co-author) in international peer-reviewed journals and 1 book chapter, delivered 3 oral presentation, and 5 poster communication. His areas of activity include (1) Synthesis and modification of nanostructures for use in cancer therapy and tissue engineering, (2) Development of NIR light-responsive nanomaterials for controlled cancer treatment, (3) Characterization of the physicochemical and biological performance of nanomaterials. Specifically, his research has been focused on gold-core silica shell nanoparticles (AuMSS) in cancer therapy, as multifunctional agents capable of combining drug delivery and photothermal therapy with their intrinsic imaging potential.
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Identification

Personal identification

Full name
Natanael Fernandes

Citation names

  • Fernandes, Natanael

Author identifiers

Ciência ID
2315-CC5A-3DBB
ORCID iD
0000-0002-7737-9288
Scopus Author Id
57217038304

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1) Advanced (C1)
French Elementary (A2) Elementary (A2) Beginner (A1) Elementary (A2) Elementary (A2)
Education
Degree Classification
2021/09 - 2026
Ongoing
 Biomedicine (Doutoramento)
Universidade da Beira Interior, Portugal
2023/07/06 - 2023/07/08
Concluded
 Course in Laboratory Animal Science - FELASA Cat. B (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022/06/27 - 2022/07/01
Concluded
 Advanced Course On Flurescence Microscopy And Image Analysis (Outros)
Universidade da Beira Interior, Portugal
2018/09 - 2020/09
Concluded
 Biochemistry (Master)
Universidade da Beira Interior, Portugal
"Development of silica-coated gold nanoclusters for cancer therapy" (THESIS/DISSERTATION)
 17
2019/07/08 - 2019/07/11
Concluded
 Young researchers training (Outros)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/09 - 2018/07
Concluded
 Biochemistry (Bachelor)
Universidade da Beira Interior, Portugal
"Derivados de glúcidos como quimioterápicos." (THESIS/DISSERTATION)
 13
Affiliation

Others

Category
Host institution 		Employer
2022/10/01 - 2026/10/01 Individual PhD fellowship (2022.14608.BD) Fundação para a Ciência e a Tecnologia, Portugal
Universidade da Beira Interior, Portugal
2022/03/21 - 2022/08/21 Research fellowship UBI-Santander Totta Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2023/01/02 - 2025/01/01 Thiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer (49,944.60 euros)
2022.06320.PTDC
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. André F. Moreira; Carolina F. Rodrigues; Fernandes, Natanael; André Figueiredo; Duarte de Melo-Diogo; Ilídio J. Correia. "Polymeric Microneedle-Based Drug Delivery Platforms for Application in Cancer Therapy". 309-324. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-17831-3_11
Conference poster
  1. Fernandes, Natanael; Borges, Soraia; Carolina F. Rodrigues; de Melo-Diogo, Duarte; Ilídio Joaquim Sobreira Correia; André F. Moreira. "Mesoporous Silica-Coated Gold Nanoclusters for Enhanced Cancer Chemo-Photothermal Therapy". Paper presented in Congress of Microbiology and Biotechnology 2023, 2023.
  2. Vanessa M. Ferro; Beatriz C. Silva; Duarte F. Macedo; Fernandes, Natanael; Abílio P. Silva. Corresponding author: Abílio P. Silva. "TCP doped with metal ions reinforced with tetragonal and cubic zirconia". Paper presented in Encontro UBI Ciencia e Comunicação - Semana da Ciencia 2023, 2023.
    10.3390/biomimetics8080599
  3. Rodrigues, Carolina F.; Fernandes, Natanael; de Melo-Diogo, Duarte; Ferreira, Paula; Correia, Ilídio J.; Moreira, André F.. "Acridine Orange loaded Gold-Core Silica Shell Nanorods functionalized with HA and PEI for Cancer-Target Photothermal and Chemotherapy". Paper presented in IV International Congress in Health Sciences Research towards innovation and entrepreneurship: Challenges from Research to Clinics, 2023.
  4. Rodrigues, Carolina F.; Fernandes, Natanael; de Melo-Diogo, Duarte; Ferreira, Paula; Correia, Ilídio J.; Moreira, André F.. "Acridine Orange loaded HA/PEI coated Gold-core Silica Shell Nanorods for Cancer-Targeted Photothermal and Chemotherapy". Paper presented in XVII International CICS-UBI Symposium, 2022.
  5. Fernandes, Natanael; Rodrigues, Carolina F.; André F. Moreira; de Melo-Diogo, Duarte; Correia, I.J.. "Optimization of the GSH-mediated formation of mesoporous silica-coated gold nanoclusters for application in photothermal therapy". Paper presented in Encontro Ciência 2021, 2021.
Journal article
  1. Vanessa M. Ferro; Beatriz C. Silva; Duarte F. Macedo; Fernandes, Natanael; Abílio P. Silva. "TCP Doped with Metal Ions Reinforced with Tetragonal and Cubic Zirconia". Biomimetics (2023): https://doi.org/10.3390/biomimetics8080599.
    Published • 10.3390/biomimetics8080599
  2. André Q. Figueiredo; Carolina F. Rodrigues; Natanael Fernandes; Ilídio J. Correia; André F. Moreira. "In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy". Biotechnology Journal (2023): http://dx.doi.org/10.1002/biot.202300019.
    10.1002/biot.202300019
  3. Rodrigues, Carolina F.; Fernandes, Natanael; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André F.. "Cell-Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enhanced Blood Circulation and Cancer Therapy". Advanced Healthcare Materials 11 23 (2022): http://dx.doi.org/10.1002/adhm.202201214.
    10.1002/adhm.202201214
  4. André Q. Figueiredo; Carolina F. Rodrigues; Natanael Fernandes; Duarte de Melo-Diogo; Ilídio J. Correia; André F. Moreira. "Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy". Nanomaterials (2022): https://doi.org/10.3390/nano12183166.
    Published • 10.3390/nano12183166
  5. Fernandes, Natanael. "HA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer-targeted photothermal and chemotherapy". Nanomedicine (2021): http://dx.doi.org/10.2217/nnm-2021-0270.
    Published • 10.2217/nnm-2021-0270
  6. Ariana S. C. Gonçalves; Rodrigues, Carolina F.; Fernandes, Natanael; de Melo-Diogo, Duarte; André F. Moreira; Correia, I.J.. "IR780 loaded gelatin-PEG coated gold core silica shell nanorods for cancer-targeted photothermal/photodynamic therapy". Biotechnology and Bioengineering (2021): http://dx.doi.org/10.1002/bit.27996.
    Published • 10.1002/bit.27996
  7. Fernandes, Natanael; Rodrigues, Carolina F.; de Melo-Diogo, Duarte; Correia, Ilídio J.; Moreira, André F.. "Optimization of the GSH-Mediated Formation of Mesoporous Silica-Coated Gold Nanoclusters for NIR Light-Triggered Photothermal Applications". Nanomaterials 11 8 (2021): 1946. http://dx.doi.org/10.3390/nano11081946.
    10.3390/nano11081946
  8. Guimarães, Rafaela S.; Rodrigues, Carolina F.; Fernandes, Natanael; de Melo-Diogo, Duarte; Ferreira, Paula; Correia, Ilídio J.; Moreira, André F.. "Combinatorial delivery of doxorubicin and acridine orange by gold core silica shell nanospheres functionalized with poly(ethylene glycol) and 4-methoxybenzamide for cancer targeted therapy". Journal of Inorganic Biochemistry (2021): 111433. http://dx.doi.org/10.1016/j.jinorgbio.2021.111433.
    10.1016/j.jinorgbio.2021.111433
  9. Fernandes, Natanael; André F. Moreira; Rodrigues, Carolina F.; Correia, I.J.. "Overview of the application of inorganic nanomaterials in cancer photothermal therapy.". Biomaterials science (2020): https://doi.org/10.1039/d0bm00222d.
    10.1039/d0bm00222d
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/04/28 Development of Gold Core Silica Shell nanomedicines for the immune/photothermal therapy of breast cancer. VI Ciclo de conferências
Universidade da Beira Interior (Covilhã, Portugal)
2023/02/13 Mesoporous Silica-Coated Gold Nanoclusters For Synergetic Chemo-Photothermal Effect. IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics
Universidade da Beira Interior (Covilhã, Portugal)
2021/09/30 Application of mesoporous silica-coated gold nanoclusters in the chemo-photothermal therapy of cancer XVI ANNUAL CICS-UBI SYMPOSIUM 2021
(Covilhã, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/09 - 2024/10 Design and characterization of Ta and Sr ion doped tricalcium phosphate bioceramic
Co-supervisor
 Bioengenharia (Master)
Universidade da Beira Interior, Portugal
2022/09 - 2023/11 Development and characterization of PLGA-Gold nanocapsules for combinatorial therapy of cancer.
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022/06 - 2023/10 Compósitos biocerâmicos de b-TCP reforçados com zirconia. Fabrico e caracterização física, mecânica, microestrutural e biológica.
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2022/04 - 2022/06 Nanopartículas inorgânicas para a fototerapia do cancro .
Supervisor
 Projeto em Bioquímica (Degree)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/02/29 - Current Member of the organizing committee for the event "The Role of Biomaterials in Regenerative Medicine", integrated into UBI Days. (2024/02/29)
Other (Member of the Organising Committee)
 Universidade da Beira Interior, Portugal
2024/03/01 - 2024/03/15 Member of the Organizing Committee of the project "Biomateriais da produção à aplicação na saúde" Inserted in the Junior STEAM Academy held at the University of Beira Interior (2024/03/01; 2024/03/08; 2024/03/15) (2024/03/01 - 2024/03/15) (2024/03 - 2024/03)
Other (Member of the Organising Committee)
 Universidade da Beira Interior, Portugal
2023/12/07 - 2023/12/09 Congress of Microbiology and Biotechnology 2023 (2023/12/07 - 2023/12/09)
Congress (Other)
 Universidade da Beira Interior, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/02/13 - 2023/02/16 IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics
Congress
 IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship - Challenges from Research to Clinics
Universidade da Beira Interior, Portugal
2022/05/16 - 2022/05/18 Ciência 2022 - Encontro com a Ciência e Tecnologia em Portugal
Conference
 Encontro com a Ciência e Tecnologia em Portugal
2021/10/30 - 2021/10/30 Origem da insónia, os seus tratamentos, e conhecer técnicas de higiene do sono.
Seminar
 Counting Sheep
Universidade de Aveiro, Portugal
2021/06/28 - 2021/06/30 Ciência 2021 - Encontro com a Ciência e Tecnologia em Portugal
Meeting
 Encontro Ciência 2021
2021/01/21 - 2021/01/21 Participation in "Scientific writing and publishing: practical tips from an editor for you article to succeed"
Workshop
 Scientific writing and publishing: practical tips from an editor for you article to succeed
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/07/04 - 2019/07/05 Participation in "XIV Annual CICS-UBISymposium"
Symposium
 XIV Annual CICS-UBISymposium
Universidade da Beira Interior, Portugal
2018/03/23 - 2018/03/26 Participation in "VI National Meeting of Chemistry Students"
Meeting
 VI National Meeting of Chemistry Students
Universidade da Beira Interior, Portugal
2016/05/04 - 2016/05/05 Participation in "IV Jornadas de Química e Bioquímica"
Other
 IV Jornadas de Química e Bioquímica
Universidade da Beira Interior, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/09 - 2025/01 Cellular and Molecular Biology (14 theoretical-practical + 14 practical hours) Bioquímica Universidade da Beira Interior, Portugal
2024/09 - 2025/01 Cellular and Molecular Biology (30 practical hours) Ciências Biomédicas Universidade da Beira Interior, Portugal
2024/09 - 2025/01 Cellular and Molecular Biology (8 practical hours) Ciências Básicas Farmacêuticas Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Biomaterials (4 theoretical-practical hours) Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Biomaterials (6 practical hours) Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Tissue Engineering (4 theoretical-practical hours) Bioquímica Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Tissue Engineering (4 theoretical-practical hours) Biotecnologia Universidade da Beira Interior, Portugal
2024/03 - 2024/06 Tissue Engineering (4 theoretical-practical hours) Ciências Biomédicas Universidade da Beira Interior, Portugal
2024/02 - 2024/06 Biomaterials (2 theoretical-practical hours) Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2024/02 - 2024/06 Tissue Engineering (4 theoretical-practical hours) Bioengenharia Universidade da Beira Interior, Portugal
2023/09 - 2024/01 Cellular and Molecular Biology (14 theoretical-practical + 14 practical hours) Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2023/09 - 2024/01 Cellular and Molecular Biology (24 practical hours) Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2023/09 - 2024/01 Cellular and Molecular Biology 16 practical hours) Ciências Básicas Farmacêuticas (Licenciatura) Universidade da Beira Interior, Portugal
2023/03 - 2023/06 Tissue Engineering (4 theoretical-practical hours) Biotecnologia (Mestrado integrado) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Biochemistry II (15 theoretical-practical + 15 practical hours) Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Tissue Engineering (2 theoretical-practical hours) Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Tissue Engineering (9 theoretical-practical hours) Bioquímica (Mestrado integrado) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Tissue Engineering (4 theoretical-practical hours) Bioengenharia (Mestrado integrado) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Biomaterials (2 theoretical-practical hours) Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Biomaterials (4 theoretical-practical hours) Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Biomaterials (6 practical hours hours) Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2023/02 - 2023/06 Biomaterials (2 theoretical-practical hours) Bioengenharia (Licenciatura) Universidade da Beira Interior, Portugal
2022/10 - 2023/01 Cellular and Molecular Biology (2 theoretical-practical + 4 practical hours) Química Industrial (Licenciatura) Universidade da Beira Interior, Portugal
2022/10 - 2023/01 Cellular and Molecular Biology (6 theoretical-practical + 6 practical hours) Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2022/10 - 2023/01 Cellular and Molecular Biology (8 practical hours) Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2022/10 - 2023/01 Cellular and Molecular Biology (12 practical hours) Ciências Farmacêuticas (Mestrado integrado) Universidade da Beira Interior, Portugal
2022/02 - 2022/04 Tissue Engineering (2 theoretical-practical hours) Ciências Biomédicas (Mestrado) Universidade da Beira Interior, Portugal
2022/02 - 2022/04 Tissue Engineering (2 theoretical-practical hours) Biotecnologia (Mestrado) Universidade da Beira Interior, Portugal
2022/02 - 2022/04 Tissue Engineering (2 theoretical-practical hours) Bioengenharia (Mestrado) Universidade da Beira Interior, Portugal
2022 - 2022 Biochemistry II (13 theoretical-practical + 13 practical hours) Ciências Farmacêuticas (Licenciatura) Universidade da Beira Interior, Portugal
2022 - 2022 Biomaterials (6 practical hours) Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2022 - 2022 Biomaterials (2 theoretical-practical hours) Bioquímica (Licenciatura) Universidade da Beira Interior, Portugal
2022 - 2022 Biomaterials (4 theoretical-practical hours) Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2022 - 2022 Biomaterials (2 theoretical-practical hours) Bioengenharia (Licenciatura) Universidade da Beira Interior, Portugal

Other jury / evaluation

Activity description Institution / Organization
2024/06 - 2024/06 Member of the jury, as an examiner, of the Biotechnology BSc project entitled "Preparação de hidrogéis termorresponsivos para futuras aplicações anticancerígenas" of the student Beatriz Oliveira Marques Universidade da Beira Interior, Portugal
2023/06 - 2023/06 Member of the jury, as an examiner, of the Biotechnology BSc project entitled "Otimização e caracterização de nanomateriais responsivos para o tratamento do cancro" of the student Pedro Marques. Universidade da Beira Interior, Portugal
2022/06/17 - 2022/06/17 Member of the jury, as an examiner, of the Biochemistry BSc project entitled "Hidrogéis injetáveis para aplicação na terapia do cancro" of the student Anita Roque. Universidade da Beira Interior, Portugal