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Patrícia Alexandra Silveira Quelhas is a dedicated researcher with extensive experience in medical and health sciences, particularly focusing on medical biotechnology and biological sciences. She is currently pursuing a doctorate in Biomedicine at the Universidade da Beira Interior's Centro de Investigação em Ciências da Saúde. Patrícia completed her licenciature degree in Biochemistry in 2015 and her master’s degree in Biochemistry in 2017, both at the Universidade da Beira Interior. Since 2017, she has been a researcher at the Centro de Investigação em Ciências da Saúde, where she has published several articles in scientific journals and participated in multiple research projects, notably in the fields of neuroscience and hepatology. Her research interests include medical biotechnology, health-related biotechnology, technologies involving the manipulation of cells, tissues, and organs, gene-based diagnostics and therapeutic interventions, anatomy and morphology, and cell biology. She has presented her work at numerous international conferences and has been involved in organizing academic events. Patrícia is proficient in English and Spanish, with advanced reading and intermediate writing and speaking skills. She has received several merit awards throughout her academic journey and continues to contribute significantly to her field.
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Identification

Personal identification

Full name
Patrícia Alexandra Silveira Quelhas

Citation names

  • Quelhas, Patricia
  • Quelhas, P
  • Quelhas, Patrícia

Author identifiers

Ciência ID
2316-8C6B-1212
ORCID iD
0000-0001-8131-3081

Email addresses

  • patricia.quelhas@fcsaude.ubi.pt (Professional)

Addresses

  • Universidade da Beira Interior . Av. Infante D.Henrique, 6200-506, Covilhã, Covilhã, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Intermediate (B1) Beginner (A1) Beginner (A1) Intermediate (B1)
Portuguese (Mother tongue)
Education
Degree Classification
2025/01/27
Concluded
 ICH Good Clinical Practice E6 (R2) (Outros)
The Global Health Network , American Samoa
2024/11/20 - 2025/01/25
Concluded
 Especialização em Clinical Research & Project Management (Curso médio)
Invictus Sciences, Portugal
2025/01/25
Concluded
 Introduction to Good Clinical Laboratory Practice (Outros)
The Global Health Network , American Samoa
2024/07/01 - 2024/07/31
Concluded
 Introduction to Quality Control (Outros)
Alison, Ireland
2024/06/01 - 2024/06/30
Concluded
 Synthetic and Molecular Biology (Outros)
Alison, Ireland
2018/09/01 - 2022/01/01
Ongoing
 Biomedicina (Doutoramento)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/09/01 - 2020/10/25
Concluded
 Science of Exercise (Curso médio)
University of Colorado Anschutz Medical Campus Bookstore, United States
 Approved
2019/01/01 - 2020/01/01
Concluded
 Treinador Basquetebol Grau II (Título de especialista)
Instituto Português do Desporto e Juventude, Portugal
 18
2019/05/01 - 2019/05/31
Concluded
 Histology - Cutting Paraffin Section (Curso médio)
King's College Hospital Liver Unit, United Kingdom
 Approved
2019/05/01 - 2019/05/31
Concluded
 Liver Pathology: Histology - Immunohistochemistry using the Leica Bond III Autostainer (Curso médio)
King's College Hospital Liver Unit, United Kingdom
 Approved
2019/01/28 - 2019/01/30
Concluded
 Serviço de Anatomia Patológica - Imunohistoquímica (Curso médio)
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2018/10/01 - 2018/11/30
Concluded
 Curso para el desempeño de las funciones B, C y D en roedores, lagomorfos, carnívoros, cerdos y pequeños rumiantes (Curso médio)
Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
 Approved
2016/09/01 - 2017/07/01
Concluded
 Treinador Desportivo Basquetebol Grau I (Título de especialista)
Instituto Português do Desporto e Juventude, Portugal
 18
2017
Concluded
 Bioquímica (Mestrado)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
"Isolamento, cultura e caracterização de células musculares lisas derivadas da artéria cerebral média de rato " (THESIS/DISSERTATION)
 18
2015
Concluded
 Bioquímica (Licenciatura)
Universidade da Beira Interior Faculdade de Ciências, Portugal
"Efeitos do Bisfenol A a nível cardíaco" (THESIS/DISSERTATION)
 13
Affiliation

Science

Category
Host institution 		Employer
2018/12/03 - Current Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/05/06 - 2019/05/31 Visiting Researcher (Research) King's College Hospital Liver Unit, United Kingdom
2018/06/01 - 2018/11/30 Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/07/16 - 2018/08/10 Visiting Researcher (Research) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal

Others

Category
Host institution 		Employer
2020/05/01 - 2020/05/31 Visiting Researcher Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Universidade de Coimbra Instituto de Anatomia Patológica, Portugal
2017/10/10 - 2018/05/31 Volunteer Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/09/01 - 2017/10/09 Biochemical Sciences MSc Student Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2018/12/03 - 2021/03/31 IsChoHep - Colangiopatia isquémica em condições de disfunção hepática
POCI-01-0145-FEDER-028956
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/06/01 - 2018/11/30 Relação entre adenosina e instabilidade cromossomal: uma nova perspetiva para compreender o mecanismo oncogénico em glioblastoma
POCI-01-0145-FEDER-016822
PTDC/BIM-ONC/7121/2014
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2019/01/01 - 2019/12/31 Health Sciences Research Centre
UID/Multi/00709/2019
Universidade da Beira Interior, Portugal

Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Quelhas, Patricia; Caetano Oliveira, Rui; dos Santos, Jorge Luiz. Corresponding author: dos Santos, Jorge Luiz. "Activation of the HIF-1alpha pathway in cholangiocytes of patients with biliary atresia and its association with cilia disruption". Paper presented in EASl International Liver Congress, 2024.
  2. Quelhas, Patricia; Breton, Michele; Verde, Ignacio; dos Santos, Jorge Luiz. "HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study". Paper presented in IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship, 2023.
  3. Quelhas, Patricia; Breton, Michele Claire; Cipriano, Maria Augusta ; Shivakumar, Pranav; Bezerra, Jorge ; Vieira, Sandra; Kieling, Carlos; Verde, Ignacio; dos Santos, Jorge Luiz. "Ischemic cholangiopathy in biliary atresia: immunohistochemical and molecular evidences". Paper presented in EASl International Liver Congress, 2021.
  4. Quelhas, Patricia; Michele C. Breton; Tomaz Grezzana; Rui C. Oliveira; Maria Augusta Cipriano; Ignacio Verde; Jorge Luiz dos Santos. "Topical hypothermia as a protective method against ischemic cholangiopathy in rat liver". Paper presented in XIV Annual CICS Symposium, 2019.
  5. Quelhas, Patricia; Prof. Doutora Graça Maria Fernandes Baltazar; Prof. Doutora Maria Elisa Cairrão Rodrigues Oliveira. "A novel method of isolation and culture of smooth muscle cells from rat middle cerebral artery". Paper presented in XIII Annual CICS Symposium, 2018.
  6. Mariana, Melissa; Quelhas, Patricia; Baltazar, Graça. "Characterization of endothelial cells culture and functionality analysis of vascular smooth muscle cells from rat middle cerebral artery". Paper presented in XIII Annual CICS-UBI Symposium, 2018.
  7. Quelhas, Patricia; Prof. Doutora Graça Maria Fernandes Baltazar; Prof. Doutora Maria Elisa Cairrão Rodrigues Oliveira. "Isolation, culture and characterization of rat middle cerebral artery smooth muscle cells". Paper presented in II International Congress in Health Sciences Research, 2017.
Encyclopedia entry
  1. Quelhas, Patricia; dos Santos, Jorge Luiz. Corresponding author: dos Santos, Jorge Luiz. "Protocols of Investigation of Neonatal Cholestasis". In Encyclopedia Journal, 2022.
    Published
Journal article
  1. Patrícia Quelhas; Rui Oliveira; Carlos Kieling; Sandra Vieira; Jorge dos Santos. "Structural Disruption of Cilia and Increased Cytoplasmic Tubulin in Biliary Atresia—An Exploratory Study Focusing on Early Postoperative Prognosis Following Portoenterostomy". Biomedicines (2025): https://doi.org/10.3390/biomedicines13010087.
    10.3390/biomedicines13010087
  2. Quelhas, Patricia; Oliveira, Rui; Santos, Jorge Luiz dos. "TOP-146 Activation of the HIF-1alpha pathway in cholangiocytes of patients with biliary atresia and its association with cilia disruption". Journal of Hepatology 80 (2024): S692. https://doi.org/10.1016/s0168-8278(24)01973-1.
    Published • 10.1016/s0168-8278(24)01973-1
  3. Quelhas, Patricia; Jacinto, Joana; Cerski, Carlos; Oliveira, Rui; Oliveira, Jorge; Carvalho, Elisa; dos Santos, Jorge. "Protocols of Investigation of Neonatal Cholestasis—A Critical Appraisal". Healthcare 10 10 (2022): 2012. http://dx.doi.org/10.3390/healthcare10102012.
    10.3390/healthcare10102012
  4. Quelhas, Patrícia; Breton, Michele Claire; Oliveira, Rui Caetano; Cipriano, Maria Augusta; Teixeira, Paulo; Cerski, Carlos Thadeu; Shivakumar, Pranavkumar; et al. "HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study". Journal of Pediatric Surgery (2022): http://dx.doi.org/10.1016/j.jpedsurg.2022.08.020.
    10.1016/j.jpedsurg.2022.08.020
  5. Quelhas, Patrícia; Cerski, Carlos; dos Santos, Jorge Luiz. "Update on etiology and pathogenesis of biliary atresia". Current Pediatric Reviews 18 (2022): http://dx.doi.org/10.2174/1573396318666220510130259.
    10.2174/1573396318666220510130259
  6. Quelhas, Patricia; Baltazar, Graça; Cairrao, Elisa. "Characterization of culture from smooth muscle cells isolated from rat middle cerebral arteries". Tissue and Cell (2020): 101400. http://dx.doi.org/10.1016/j.tice.2020.101400.
    Published • 10.1016/j.tice.2020.101400
  7. Quelhas, Patricia. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry (2019): http://dx.doi.org/10.1111/jnc.14937.
    10.1111/jnc.14937
  8. Patrícia Quelhas; Graça Baltazar; Elisa Cairrao. "The Neurovascular Unit: Focus on the Regulation of Arterial Smooth Muscle Cells". Current Neurovascular Research 16 (2019): https://doi.org/10.2174/1567202616666191026122642.
    10.2174/1567202616666191026122642
Thesis / Dissertation
  1. Quelhas, Patrícia Alexandra Silveira. "Isolamento, cultura e caracterização de células musculares lisas derivadas da artéria cerebral média de rato". Master, 2017. http://hdl.handle.net/10400.6/6391.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/06/07 Poster presentation "Activation of the HIF-1alpha pathway in cholangiocytes of patients with biliary atresia and its association with cilia disruption" at EASL International Liver Congress EASl International Liver Congress
EASL (Milan , Italy)
2021/05/25 Ischemic cholangiopathy in biliary atresia: immunohistochemical and molecular evidences EASl International Liver Congress
European Association for the Study of the Liver
2019/06/21 Ischemic cholangiopathy in the rat model of late ischemia-reperfusion injury 28th Meeting of european society of paediatric clinical research
(Debrecen, Hungary)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/09/01 - Current Activation of the HIF-1alpha pathway in cholangiocytes of patients with biliary atresia and its association with cilia disruption
Co-supervisor of Diogo Morgado
Medicina (Master)
Universidade da Beira Interior, Portugal
2025/03/03 - 2025/06/14 Estudo da expressão de genes relacionados com hipóxia em fígados de ratos submetidos a diferentes condições de transplante hepático
Supervisor of Laura Vieira
 Bioquimica (Degree)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2025/02/28 - 2025/06/14 Estudo da expressão de genes relacionados com hipóxia em fígados de ratos submetidos a diferentes condições de transplante hepático
Supervisor of Renato Luís
 Bioquimica (Degree)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2024/01/01 - 2024/06/30 Associação entre Hipóxia, Ciliopatia e Atresia Biliar: Implicações Moleculares e Clínicas
Supervisor of Ana Carolina Cruz
 Bioquímica (Degree)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/01/01 - 2023/02/16 Member of the Organizing Committee of The IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinics (2023/02/13 - 2023/02/15)
Congress (Member of the Organising Committee)
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/02/12 - 2023/02/15 Poster Presentation at IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship entitled "HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study"
Congress
 IV International Congress on Health Sciences Research: Towards Innovation and Entrepreneurship
2019/07/04 - 2019/07/05 Poster presentation: "Patrícia Quelhas, Michele C. Breton, Tomaz Grezzana, Rui C. Oliveira, Maria A. G. Cipriano, Ignacio Verde, Jorge L. Santos, Topical hypothermia as a protective method against ischemic cholangiopathy in rat liver" at XIV Annual CICS-UBI Symposium, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã.
Symposium
 XIV Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/07/05 - 2018/07/06 Poster presentation: "Quelhas P, Baltazar G, Cairrão E., A novel method of isolation and culture of smooth muscle cells from rat middle cerebral artery" at XIII Annual CICS-UBI Symposium
Symposium
 XIII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/10/12 - 2017/10/14 Attendance at 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Congress
 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/07/06 - 2017/07/07 Attendance at XII Annual CICS-UBI Symposium
Symposium
 XII Annual CICS-UBI Symposium
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/05/17 - 2017/05/20 Poster presentation: " Quelhas P, Baltazar G, Cairrão E., Isolation, culture and characterization of rat middle cerebral artery smooth muscle cells" at II International Congress in Health Sciences: Research towards innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
Congress
 II International Congress in Health Sciences: Research towards innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/07/01 - 2015/07/04 Formação Jovens Investigadores
Other
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2021/01/01 - 2023/06/30 Member of the Doctoral Student Commission of CICS-UBI (CAD-CICSUBI)
Member
 Universidade da Beira Interior, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/02/18 - 2025/02/19 Base de dados - Análise através do SPSS Ciências Básicas Farmacêuticas (Licenciatura) Universidade da Beira Interior, Portugal
2025/02/04 - 2025/02/05 Separação de lixo biológico e Técnicas de Pipetagem e Pesagem Ciências Básicas Farmacêuticas (Licenciatura) Universidade da Beira Interior, Portugal
2025/01/08 - 2025/01/09 Medição da Tensão Arterial com Esfigmomanómetro Ciências Farmacêuticas Universidade da Beira Interior, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2025/01/01 - Current Annals of Pediatrics and Neonatal Care

Other jury / evaluation

Activity description Institution / Organization
2024/06/12 - Current I participated as an examiner in the defense of the project entitled "Study of the role of the TAS2R14 in the blood-cerebrospinal fluid barrier’s integrity and permeability," carried out by Lara Neto within the scope of the Biochemistry Project Course of the 1st cycle in Biochemistry at the University of Beira Interior. Universidade da Beira Interior, Portugal
Distinctions

Award

2011 Secondary School Merit Award
Câmara Municipal da Covilhã, Portugal
2007 9th grade School Merit Award
Câmara Municipal da Covilhã, Portugal
2006 8th grade School Merit Award
Câmara Municipal da Covilhã, Portugal

Other distinction

2024 Conference TOP Poster
EASL International Liver Foundation, Italy