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Sara Cristina Sequeira Alves. Completed the Doutoramento in Programa Doutoral em Biologia Molecular e Ambiental in 2014 by Universidade do Minho Escola de Ciências, Mestrado in Mestrado em Genética Molecular in 2009 by Universidade do Minho Escola de Ciências and Licenciatura in Biologia Aplicada in 2007 by Universidade do Minho Escola de Ciências. Was awarded an Auxiliary Researcher contract in Universidade do Porto Instituto de Investigação e Inovação em Saúde, starting in May 2022. Published 9 articles in journals. Organized 1 event(s). Participated in 2 event(s). Co-supervised 3 MSc dissertation(s). Participates and/or participated as Post-doc Fellow in 2 project(s) and Researcher in 2 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Microbiology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: 577.2; Ciências Naturais::Ciências Biológicas; Apoptosis; Programmed cell death; Lisosome; Mitochondria; Experimental Biology - Cellular and Molecular Biology; .
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Identification

Personal identification

Full name
Sara Cristina Sequeira Alves

Citation names

  • Alves, Sara
  • Alves, S

Author identifiers

Ciência ID
2319-A4DB-AE55
ORCID iD
0000-0003-0404-5954
Researcher Id
U-5006-2019
Scopus Author Id
36626985200

Email addresses

  • sara.csa@gmail.com (Professional)
  • sara.alves@i3s.up.pt (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Microbiology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Spanish; Castilian Elementary (A2) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014
Concluded
 Programa Doutoral em Biologia Molecular e Ambiental (Doutoramento)
Universidade do Minho Escola de Ciências, Portugal
"Impact of mutated KRAS signalling on autophagy regulation in colorectal carcinoma" (THESIS/DISSERTATION)
 Aprovada por unanimidade
2009
Concluded
 Mestrado em Genética Molecular (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"Regulação da autofagia pelo KRAS de modo a compreender o seu papel no cancro humano" (THESIS/DISSERTATION)
 18
2007
Concluded
 Biologia Aplicada (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"-" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/05/01 - 2024/04/30 Auxiliary Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/01/15 - 2021/07/15 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
(...)
2018/05/01 - 2018/10/30 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
(...)
2017/05/01 - 2018/04/30 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
(...)
2014/06/01 - 2016/09/30 Postdoc (Research) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
Projects

Grant

Designation Funders
2022/05 - 2028/04 Control of plasma membrane repair mechanisms by Ca2+-responsive proteins
7653EEC
2021.02533.CEECIND/CP1663/CT0006
10.54499/2021.02533.CEECIND/CP1663/CT0006
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01 - 2025/12 Instituto de Investigação e Inovação em Saúde
168202UID
154602UID
 Fundação para a Ciência e a Tecnologia
2019/01 - 2019/12 CENTRO DE BIOLOGIA MOLECULAR E AMBIENTAL
154698UID
 Fundação para a Ciência e a Tecnologia
2017/05/01 - 2018/04/30 Advancing cancer research: from basic knowledgment to application
NORTE-01-0145-FEDER-000029
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 European Regional Development Fund
Concluded
2014/06/01 - 2016/09/29 Phosphoregulation of Bax-dependent cell death
info:eu-repo/grantAgreement/FCT/3599-PPCDT/125757/PT
Post-doc Fellow
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01 - 2013/12 THE ROLE OF KRAS AND CERAMIDE PATHWAYS IN AUTOPHAGY REGULATION TOWARDS UNDERSTANDING ITS ROLE IN COLORECTAL CARCINOMA
28720DFA
SFRH/BD/64695/2009
Universidade do Minho Escola de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Research and Innovation in Health
LA/P/0070/2020
10.54499/LA/P/0070/2020
UID/BIM/04293/2019
Instituto de Astrofísica e Ciências do Espaço, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/15 - 2021/07/14 Enlighten host plasma membrane repair mechanisms upon bacterial pore-forming toxins attack
POCI-01-0145-FEDER-030863
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CENTRE OF MOLECULAR AND ENVIRONMENTAL BIOLOGY
UID/BIA/04050/2019
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/05/01 - 2018/10/31 Advancing cancer research: from basic knowledgment to application
NORTE-01-0145-FEDER-000029
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 European Regional Development Fund
Concluded
Outputs

Publications

Conference paper
  1. Salazar S.B.; Pedreira T.; Wang C.; Henriques R.; Alves, Sara; Sousa M.J.; Lopes M.M.; et al. "Comparative genomic and transcriptomic analysis unveil novel features of antifungal resistance in the human pathogen Candida glabrata.". Paper presented in 7th Trends in Medical Mycology, Lisboa, 2015.
  2. Salazar S.B.; Lopes M.M.; Alves, Sara; Sá-Correira I.; Sousa, M.J.; Mira N.P.. "A genomic analysis on resistance of the human pathogen Candida glabrata to azoles and echinocandins.". Paper presented in Conference paper at XX Jornadas Van Uden, Lisboa, 2014.
  3. Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; et al. "Vacuole-mitochondrial crosstalk during apoptosis induced by acetic acid in yeast". 2011.
  4. Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; et al. "What yeast can tell us about how cells commit suicide?". 2011.
Conference poster
  1. Pereira, J. M.; Alves, Sara; Xu, Shuying ; Cabanes, Didier; Leong, John; Sousa, Sandra. "S100A4 is a master regulator of cytoskeleton remodeling induced by pneumolysin pore formation". Paper presented in Cell Bio 23, 2023.
  2. Pereira, J. M.; Alves, Sara; Cabanes, Didier; Sousa, Sandra. "Mechanisms of host resistance to plasma membrane damage induced by pneumolysin attack". Paper presented in ISEV2020, 2020.
  3. Pereira, F.; Cazzanelli, G; Carvalho, P.D.; Alves, Sara; Costa, A.M.; Gomez-Lazaro, M.; Reis, C.A.; Oliveira, M.J.; Preto, A.. "Dissecting the impact of KRAS/Galectin-3 complex at the colorectal tumor microenvironment.". Paper presented in i3S Annual Meeting 2019, 2019.
  4. Pereira, F.; Cazzanelli, G.; Carvalho, P.D.; Alves, Sara; Costa, A.M.; Gomez-Lazaro, M.; Reis, C.A.; Oliveira, M.J.; Preto, A.. "Unravel the role of KRAS/Galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages". Paper presented in V Symposium of the Doctoral Program on Molecular and Environmental Biology, 2019.
  5. Pereira, F.; Cazzanelli, G.; Carvalho, P.D.; Alves, Sara; Costa, A.M.; Gomez-Lazaro, M.; Reis, C.A.; Oliveira, M.J.; Preto, A.. "Unravel the role of KRAS/Galectin-3 loop in the crosstalk between colorectal cancer cells and tumor-associated macrophages.". Paper presented in 2nd PhDay: PhD Countdown, A time for Science., 2019.
  6. Pereira, F.; Cazzanelli, G.; Carvalho, P.D.; Alves, Sara; Costa, A.M.; Gomez-Lazaro, M.; Oliveira, M.J.; Preto, A.. "Identification of a novel KRAS/Galectin-3/p16INK4a triple axis in colorectal cancer.". Paper presented in IV Symposium of the Doctoral Program on Molecular and Environmental Biology, 2018.
  7. Pereira, F.; Cazzanelli, G.; Carvalho, P.D.; Alves, Sara; Costa, A.M.; Pinto, M.L.; Gomez-Lazaro, M.; Oliveira, M.J.; Preto, A.. "Identification of a novel KRAS/Galectin-3/p16INK4a triple axis in colorectal cancer: therapeutic implications.". Paper presented in 3rd Portuguese Association for Research in Cancer (ASPIC) International Congress, 2018.
  8. Pereira, F.; Almeida, A.; Cazzanelli, G.; Carvalho, P.D.; Alves, S.; Costa, A.M.; Pinto, M. L.; et al. "Unveil the KRAS/Galectin-3/p16INK4a triple axis regulation in colorectal cancer.". Paper presented in 25th Porto Cancer Meeting, 2018.
    10.1136/esmoopen-2018-eacr25.794
  9. Castro, L.; Alves, Sara; Pereira, C.; Chaves, S.R.; Sousa, M.J.; Manon, S.; Côrte-Real, M.. "Yeast as a tool to identify novel kinases involved in regulation of Bax.". Paper presented in Microbiotec 15, 2015.
  10. Castro, L.; Alves, Sara; Pereira, C.; Chaves, S.R.; Sousa, M.J.; Manon, S.; Côrte-Real, M.. "Yeast as a system model to characterize Bax regulation by individual kinases". Paper presented in III Symposium of the PhD Programme on Molecular and Environmental Biology, 2015.
  11. Ferro S.; Pereira, H.; Alves, Sara; Castro L.; Chaves SR.; Preto, A.; Côrte-Real, M.. "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria". Paper presented in XI International Meeting on Yeast Apoptosis, 2015.
  12. Alves, S.; Castro, L.; Fernandes, Maria Sofia ; Castro, P.; Priault, M.; Chaves, S.R.; Moyer, M.P.; et al. "Hotspot mutations in the KRAS oncogene function as positive regulators of autophagy in colon. XIII Porto Cancer Meeting-Stem Cells and Cancer; 7-8 May 2015, Porto, Portugal.". Paper presented in XIII Porto Cancer Meeting-Stem Cells and Cancer, 2015.
  13. Castro, L.; Alves, Sara; Pereira, C.; Chaves, S.R.; Sousa, M.J.; Manon, S.. "Identification of protein kinases involved in the phosphoregulation of Bax- dependent cell death.". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015.
  14. Oliveira, C.S.F.; Pereira, H.; Alves, Sara; Castro, L.; Baltazar, F.; Chaves, S.R.; Côrte-Real, M.; Preto, A.. "Cathepsin D protects colorectal cancer cells from acetate- induced apoptosis through autophagy-independent degradation of damaged mitochondria.". Paper presented in XXXIX Jornadas Portuguesas de Genética, 2015.
  15. Alves, Sara; Castro, L.; Fernandes, M.S.; Castro, C.; Priault, M.; Chaves, S.R.; Côrte-Real, M.; Sousa, M.J.; Preto, A.. "Hotspot mutations in the KRAS oncogene function as positive regulators of autophagy in the colon.". Paper presented in XXIII Porto Cancer Meeting: Stem Cells and Cancer, 2015.
  16. Oliveira, C.S.F.; Pereira, H.; Alves, Sara; Castro, L.; Baltazar, F.; Chaves, S.R.; Côrte-Real, M.; Preto, A.. "Cathepsin D is involved in the degradation of damaged mitochondria during acetate-induced apoptosis in colorectal cancer cells.". Paper presented in XXIII Porto Cancer Meeting: Stem Cells and Cancer, 2015.
  17. Alves, Sara; Castro, L.; Chaves, S.R.; Sousa, M.J.; Manon, S.; Côrte-Real, M.. "Phosphoregulation of Bax-dependent cell death: towards the identification of new protein kinases as molecular targets for cancer therapy.". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  18. Oliveira, C.S.F.; Pereira, H.; Alves, Sara; Castro, L.; Chaves, S.R.; Preto, A.; Côrte-Real, M.. "Cathepsin D protects colorectal carcinoma cells from acetate-induced apoptosis through autophagy-in-dependent degradation of damaged mitochondria: a new function unveiled by the yeast vacuolar protease Pep4.". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  19. Oliveira, C.S.F.; Pereira, H.; Alves, Sara; Chaves, S.R.; Sousa, M.J.; Preto, A.; Côrte-Real, M.. "The yeast vacuolar protease Pep4p unveils a novel function of the human Cathepsin D during acetate-induced mitochondrial apoptosis in colorectal carcinoma cells.". Paper presented in International Meeting on Yeast Apoptosis, 2014.
  20. Oliveira, C.S.F.; Marques, C.; Alves, Sara; Chaves S.R.; Côrte-Real, M.; Preto, A.. "Acetate induces lysosomal membrane permeabilization cathepsin D release and impairs autophagy in colorectal carcinoma cells.". Paper presented in 2nd EACR Special Conference on Cell Death in Cancer, 2014.
  21. Oliveira, C.S.F.; Marques, C.; Alves, Sara; Chaves, S.R.; Coutinho, O.P.; Côrte-Real, M.; Preto, A.. "Involvement of lysosomal membrane permeabilization and cathepsin D release in colorectal carcinoma cells acetate-induced apoptosis.". Paper presented in I Symposium of the PhD Programme on Molecular and Environmental Biology, 2013.
  22. Alves, Sara; Chaves, S.R.; Oliveira, C.; Seruca, R.; Côrte-Real, M.; Preto, A.; Sousa, M.J.. "Unravel the role of KRAS in autophagy control in colorectal carcinoma: Saccharomyces cerevisiae as a model system.". Paper presented in X International Meeting on Yeast Apoptosis, 2013.
  23. Alves, Sara; Chaves, S.R.; Oliveira, C.; Seruca, R.; Côrte-Real, M.; Preto, A.; Sousa, M.J.. "The role of KRAS mutations in autophagy regulation in colorectal carcinoma.". Paper presented in Porto Cancer Meeting 2012, 2012.
  24. Alves, Sara; Chaves, S. R.; Oliveira, C.; Seruca, R.; Côrte-Real, M.; Preto, A.; Sousa, M.J.. "The role of human oncogen KRAS in autophagy regulation: Saccharomyces cerevisiae as a model system.". Paper presented in XII Jornadas de Biologia Aplicada, 2011.
  25. Alves, Sara; Chaves, S. R.; Oliveira, C.; Seruca, R.; Côrte-Real, M.; Preto, A.; Sousa, M.J.. "The role of human oncogene KRAS in autophagy regulation: Saccharomyces cerevisiae as a model system.". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  26. Marques, C.; Alves, Sara; Côrte-Real, M.; Coutinho, O.P.. "The involvement of the lysosome in death induced by acetate in colorectal carcinoma cells harboring different genetic backgrounds.". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
Journal article
  1. Sara Alves; Cátia Santos-Pereira; Claudia Suellen Ferro Oliveira; Ana Preto; Susana R. Chaves; Manuela Côrte-Real. "Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration". Biomolecules (2024): http://dx.doi.org/10.3390/biom14040473.
    10.3390/biom14040473
  2. Sara Alves; Joana M. Pereira; Rupert L. Mayer; Alexandre D. A. Gonçalves; Francis Impens; Didier Cabanes; Sandra Sousa. "Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins". Toxins (2022): https://doi.org/10.3390/toxins15010004.
    10.3390/toxins15010004
  3. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.". Autophagy (2021): https://doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  4. Cazzanelli G; Pereira F; Alves S; Francisco R; Azevedo L; Dias Carvalho P; Almeida A; et al. "The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.". Cells (2018): http://europepmc.org/abstract/med/29463063.
    10.3390/cells7020014
  5. Alves, S.; Neiri, L.; Chaves, S.R.; Vieira, S.; Trindade, D.; Manon, S.; Dominguez, V.; et al. "N-terminal acetylation modulates Bax targeting to mitochondria". International Journal of Biochemistry and Cell Biology 95 (2018): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038257457&partnerID=MN8TOARS.
    10.1016/j.biocel.2017.12.004
  6. Neri, L.; Lasa, M.; Elosegui-Artola, A.; D'Avola, D.; Carte, B.; Gazquez, C.; Alve, S.; et al. "NatB-mediated protein N-a-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma". Oncotarget 8 25 (2017): 40967-40981. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020925750&partnerID=MN8TOARS.
    10.18632/oncotarget.17332
  7. Oliveira, C.S.F.; Pereira, H.; Alves, S.; Castro, L.; Baltazar, F.; Chaves, S.R.; Preto, A.; Côrte-Real, M.. "Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagyindependent degradation of damaged mitochondria". Cell Death and Disease 6 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989827781&partnerID=MN8TOARS.
    10.1038/cddis.2015.157
  8. Castro, L.; Alves, S.; Chaves, S.R.; Costa, J.L.; Soares, P.; Preto, A.. "RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation". Molecular and Cellular Endocrinology (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84940054619&partnerID=MN8TOARS.
    10.1016/j.mce.2015.08.006
  9. Alves, S.; Castro, L.; Fernandes, M.S.; Francisco, R.; Castro, P.; Priault, M.; Chaves, S.R.; et al. "Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy". Oncotarget 6 31 (2015): 30787-30802. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945530861&partnerID=MN8TOARS.
    10.18632/oncotarget.5021
  10. Marques C; Oliveira CS; Alves S; Chaves SR; Coutinho OP; Côrte-Real M; Preto A. "Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.". (2013): http://europepmc.org/abstract/med/23429293.
    10.1038/cddis.2013.29
  11. Pereira, C.; Chaves, S.; Alves, S.; Salin, B.; Camougrand, N.; Manon, S.; Sousa, M.J.; Côrte-Real, M.. "Mitochondrial degradation in acetic acid-induced yeast apoptosis: The role of Pep4 and the ADP/ATP carrier". Molecular Microbiology 76 6 (2010): 1398-1410. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953492945&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2010.07122.x
Thesis / Dissertation
  1. Alves, Sara Cristina Sequeira. "Impact of mutated KRAS signalling on autophagy regulation in colorectal carcinoma". PhD, 2014. http://hdl.handle.net/1822/40410.
  2. Alves, Sara Cristina Sequeira. "Regulação da autofagia pelo KRAS de modo a compreender o seu papel no cancro humano". Master, 2009. http://hdl.handle.net/1822/10773.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018/11/22 Understanding the role of KRAS hotspot mutations in the regulation of the p16INK4a/KRAS/Galectin-3 axis in colorectal cancer (Presented by Pereira, F.) 11ª Edição do IJUP
Universidade do Porto (Porto, Portugal)
2018/04/26 Unveil the KRAS/Galectin-3/p16INK4a triple axis regulation in colorectal cancer. (Presented by Pereira, F.) 25th Porto Cancer Meeting
Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2018/02/07 Understanding the role of KRAS hotspot mutations in KRAS/Galectin-3/p16INK4a axis regulation in colorectal cancer. (Presented by Pereira, F.) Young Researcher Meeting of University of Porto
Universidade do Porto (Porto, Portugal)
2017/11/09 Understanding the role of KRAS hotspot mutations in the KRAS/Galectin-3/p16INK4a axis regulation in colorectal cancer. (Presented by Pereira, F.) in i3S Annual Meeting 2017
Instituto de Investigação e Inovação em Saúde, Universidade do Porto (Póvoa do Varzim, Portugal)
2015/09/29 Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy. Presented by Sara Alves) XI International Meeting on Yeast Apoptosis
Universidade do Minho (Porto, Portugal)
2015/09/29 Yeast as a tool to identify novel kinases involved in regulation of Bax. (Presented by Castro, L.) XI International Meeting on Yeast Apoptosis
Universidade do Minho (Porto, Portugal)
2015/09/23 Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy. (Presented by Preto, A.) GlycoBiology Summer School
Universidade do Minho (Braga, Portugal)
2015/04/15 Identification of protein kinases involved in the phosphoregulation of Bax- dependent cell death. (Presented by Castro, L.) VIII Jornadas de Bioquímica
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2014/11/27 Phosphoregulation of Bax-dependent cell death: towards the identification of new protein kinases as molecular targets for cancer therapy. (Presented by Castro, L.) II Symposium of the PhD Programme on Molecular and Environmental Biology
Universidade do Minho (Braga, Portugal)
2014/11/17 Does N-terminal acetylation of Bax regulates its function? CIMA Seminars
University of Navarra (Pamplona, Spain)
2014/05/28 Impact of mutated KRAS signaling on autophagy regulation in colorectal carcinoma. DBio Seminars
University of Minho (Braga, Portugal)
2013/11/28 Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy. (Presented by Sara Alves) I Symposium of the PhD Programme on Molecular and Environmental Biology
Universidade do Minho (Braga, Portugal)
2011/05/27 Unravel the role of KRAS in autophagy control in colorectal carcinoma: Strategies from yeast to human cells. DBio Seminars
Universidade do Minho
2011/05/02 Vacuole-mitochondrial crosstalk during acetic acid-induced yeast apoptosis. (Presented by Chaves, S.R.) 8th International Meeting on Yeast Apoptosis
(Canterbury, United Kingdom)
2011/04 What yeast can tell us about how cells commit suicide? (Presented by Chaves, S.R.) Portugal e a Genetica
(Porto, Portugal)
2010 A yeast heterologous expression system to understand the role of human oncogene KRAS in autophagy regulation. (Presented by Sara Alves) XXXV Jornadas Portuguesas de Genética 2010
Universidade do Minho (Braga, Portugal)
2010 Acetic acid-induced apoptosis in Saccharomyces cerevisiae. (Presented by Chaves, S.R.) Society of General Microbiology-Autumn 2010 Meeting
University of Nottingham (Nottingham, United Kingdom)
2010 A non-autophagic role for the vacuole in mitochondrial degradation during acetic acid-induced yeast apoptosis. (Presented by Chaves, S.R.) 9th International Mycology Congress
(Edinburgh, United Kingdom)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/09 - 2019/07 Evaluation of the cytotoxic effect of novel liposomal formulations in triple-negative breast cancer cell lines
Co-supervisor
 Mestrado em Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2015/09 - 2016/10 Bax activation by PKC modulation: an attractive target to eliminate cancer cells
Co-supervisor
 Mestrado em Genética Molecular (Master)
Universidade do Minho Escola de Ciências, Portugal
2013/09 - 2014/12 Understanding the role of KRAS-regulated autophagy in colorectal cancer: therapeutic implications
Co-supervisor
 Mestrado em Genética Molecular (Master)
Universidade do Minho Escola de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2013/11 - 2013/11 I Symposium Program on Molecular and Environmental Biology (2013/11 - 2013/11)
Symposium (Member of the Organising Committee)
 Universidade do Minho Escola de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2019/11/28 - 2019/11/29 8th i3S Annual Meeting, Póvoa de Varzim, Portugal
Meeting
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/05/15 - 2018/05/15 Conferencias em Oncobiologia, ICBAS/FFUP, Porto, Portugal
Conference
 Conferencias em Oncobiologia
Universidade do Porto Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018/04 The role of metabolism in the sensitivity of Saccharomyces cerevisiae to the anti-cancer agent cisplatin
(Thesis) Main arguer
 Leslie Ann Silva Amaral (Master)
Universidade do Minho Escola de Ciências, Portugal
2017/03/15 The mechanism underlying proteasome-mediated sensitivity to the chemotherapeutic agent cisplatin
(Thesis) Main arguer
 Nuno Miguel Faria Machado (Master)
Universidade do Minho Escola de Ciências, Portugal
2015/02/09 O envolvimento da via Ras-PKA na sensibilidade da S. cerevisiae ao agente quimioterápico cisplatina
(Thesis) Main arguer
 Vera Mónica Maia Martins (Master)
Universidade do Minho Escola de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/07/09 - 2018/07/13 Theoretical and Experimental sessions about “ Estudo da atividade antitumoral de compostos" Ciencia Viva (Ensino secundário) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/06 - 2015/06 Lecture about “Colon cancer-related mutant KRAS alleles function as positive regulators of autophagy.” Advanced course in Mammalian and yeast as complementary models in programmed cell death Universidade do Minho, Portugal
2013/06 - 2013/06 Lecture about “The role of KRAS mutations in autophagy regulation in colorectal carcinoma.” Advanced course in Cancer Therapy Universidade do Minho, Portugal
2012/06 - 2012/06 Lecture about "The role of KRAS mutations in autophagy regulation in colorectal carcinoma." Advanced course in Mammalian and yeast as complementary models in programmed cell death Universidade do Minho, Portugal
2011/06 - 2011/06 Lecture about "Unravel the role of KRAS in autophagy control in colorectal carcinoma: Saccharomyces cerevisiae as a model system" Advanced course in Mammalian and yeast as complementary models in programmed cell death Universidade do Minho, Portugal