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João José Simões Sousa obtained his Master’s degree in Pharmacy from the University of Coimbra, and joined the technical staff of a major Portuguese pharmaceutical company. Meanwhile, he became involved with the incipient regulatory field back in 1984. In 1987, he started his academic career at the Faculty of Pharmacy, University of Coimbra. After completing his PhD (1996), he started his collaboration with the Infarmed (Portuguese Regulatory Agency) and, since then he has been involved with the different regulatory areas, in particular as Quality Expert for submitted dossiers Centralized Procedures, National, MRP, DCP, Variations, and Renewals). He is now dealing with Scientific Advices. Based on his experience, he proposed the inclusion of the subject “Regulatory Affairs” in the academic curriculum of the Masters Degree at the Faculty of Pharmacy, being responsible for that subject. Meanwhile, he developed his research career, focusing mainly in sustained release dosage forms and transdermal devices. He is currently Professor of Pharmaceutical Technology at the University of Coimbra and member of Directive Board of UCNext. Authored more than one hundred papers in peer review journals, 8 book chapters, and two books. Presented several oral communications and invited lectures both nationally and abroad. He supervised around 20 Ph.D. dissertations and several Master thesis. He has been invited as an examiner of Ph.D. thesis in national and international universities. The last developments in his scientific career are focused on new pharmaceutical approaches to the treatment of cancer, in particular glioblastoma. The knowledge gained while as a quality expert helps the rational development of medicines from bench to commercial products.
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Identification

Personal identification

Full name
João José Martins Simões de Sousa

Citation names

  • Sousa, João
  • Sousa, JJ

Author identifiers

Ciência ID
2410-6938-C5DC
ORCID iD
0000-0001-9718-8035

Telephones

Mobile phone
  • 965083960 (Personal)

Addresses

  • Faculdade de Farmácia da Universidade de Coimbra Pólo das Ciências da Saúde Azinhaga de Santa Comba , 3000-548 , Coimbra, Coimbra, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Elementary (A2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2007/01/14
Concluded
 João José Martins Simões de Sousa (Título de Agregado)
Universidade de Coimbra, Portugal
"The influence of formulation on the formation of and drug release from film coated pellets" (THESIS/DISSERTATION)
1993/01/05 - 1996/12/11
Concluded
 Joao Jose Simoes Sousa (Doutoramento)
Universidade de Coimbra, Portugal
"The influence of formulation on the formation of and drug release from film coated pellets" (THESIS/DISSERTATION)
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1986/11/01 - Current Associate Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Projects

Contract

Designation Funders
2023/03/12 - 2026/03/11 Interação calcitonina-receptor promovida por nanopartículas guiadas por péptidos como uma nova abordagem para tratamento de glioblastoma
10.54499/2022.06174.PTDC
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2023/06/30 Enhancing epithelial permeability: a nanotechnology-based solution for epi-on corneal cross-linking
EXPL/BIA-BQM/0042/2021
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/07 - 2022/09 Sustainable Edible Polymeric Films
Universidade de Coimbra Centro de Investigação em Engenharia dos Processos Químicos e dos Produtos da Floresta, Portugal
 Universidade de Coimbra

Santander Universities
Ongoing
2018/06/22 - 2022/04/21 Development of a Novel Nose-to-Brain multifunctional nanoplatform for the treatment of Depression and prevention of pharmacoresistance development
PTDC/SAU-SER/30752/2017
CENTRO-01-0145-FEDER-030752
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Associação para a Inovação e Desenvolvimento da FCT

Fundação para a Ciência e a Tecnologia
Ongoing
2016/07/01 - 2019/06/30 Co-encapsulação em transportadores lipídicos nanoestruturados como uma plataforma multifuncional para o tratamento de tumores cerebrais
PTDC/CTM-NAN/2658/2014
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/05/01 - 2013/10/31 Anti-inflammatory mechanism and properties of medicinal plants: a multidisciplinary research for their validation and utilization as a source of phytopharmaceuticals
PTDC/SAU-FCF/105429/2008
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105429/PT
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade de Coimbra, Portugal
Associação para a Inovação e Desenvolvimento da FCT

Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/07/31 Interactions in polyelectrolyte complexes: simulation and experiment
PTDC/QUI-QUI/101442/2008
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Química de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/08/31 Improvement of insulin oral availability through encapsulation in polyelectrolyte complex nanoparticles
POCI/SAU-FCF/59940/2004
Provided by PTCRIS: 59940
Instituto Universitário de Ciências da Saúde, Portugal

Universidade de Coimbra, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Carla Vitorino, João Sousa e Alberto Pais. Nanotheranostics and Cancer: Where Are We Now?. 2018.
    Published • Editor
  2. Carla Vitorino, João Sousa, Alberto Pais. Simvastatin delivery: Challenges and Opportunities. New York, United States: Nova Science Publishers, Incorporated. 2015.
    Published • Editor
Book chapter
  1. Basso, João; Mendes, Maria; Ferreira, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Recent in vitro Models for the Blood-Brain Barrier". In Nanoparticles for Brain Drug Delivery, 383-405. Jenny Stanford Publishing, 2021.
    10.1201/9781003119326-15
  2. Basso, João; Mendes, Maria; Fortuna, Ana; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, Carla. "Chapter 15: Nanotechnological approaches in cancer: the role of Celecoxib and Disulfiram.". In Drug Repurposing in Cancer Therapy: Approaches and Applications. Elsevier, 2020.
    Published
  3. Basso, João; Silva, Jessica; Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Cell Membrane-Mimetic Nanoparticles for Cancer Treatment: What Has Been Done So Far?". In Nanoparticle Drug Delivery Systems for Cancer Treatment, 75-103. Jenny Stanford Publishing, 2020.
    10.1201/9780429341250-4
  4. Silva, Jessica; Basso, João; Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Tailoring drug and gene codelivery nanosystems for glioblastoma treatment". In Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents, 141-182. Elsevier, 2020.
    10.1016/b978-0-12-819666-3.00005-5
  5. Basso, João; Mendes, Maria; Fortuna, Ana; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, Carla. "Nanotechnological approaches in cancer". In Drug Repurposing in Cancer Therapy, 353-393. Elsevier, 2020.
    10.1016/b978-0-12-819668-7.00014-2
  6. Mendes, Maria; Barone, Antonella; Sousa, João; Pais, Alberto; Vitorino, Carla. "Gold Nanorods as Theranostic Nanoparticles for Cancer Therapy". In Nanotheranostics, 363-404. Springer International Publishing, 2019.
    10.1007/978-3-030-29768-8_16
  7. Mendes, Maria; Sousa, João; Pais, Alberto; Vitorino, Carla. "Clinical applications of nanostructured drug delivery systems". In Core-Shell Nanostructures for Drug Delivery and Theranostics, 43-116. Elsevier, 2018.
    10.1016/b978-0-08-102198-9.00004-1
  8. Silva, Jessica; Miranda, Ana; Sousa, João; Pais, Alberto; Vitorino, Carla. "Impact of Immunotherapy in the Treatment of Glioblastoma". In Biopharmaceuticals. InTech, 2018.
    Published • 10.5772/intechopen.78603
  9. Campos, M.G.; Sousa, João; Aguiar, Danielle. "Biological and Functional Properties of Bee Products for Medicinal Purposes". In Traditional and Folk Herbal Medicine: Recent Researches, 541-562. -, India: Daya Publishing House, 2013.
    Published
  10. Santos, H. & Sousa, J.. "Tablet Compression". In Pharmaceutical Manufacturing Handbook - Production and Processes, 1133-1163. New Jersey, United States: John Wiley & Sons, Inc., 2008.
    Published
Conference paper
  1. Mendes, Maria; Basso, João; Sousa, João; Pais, Alberto; Vitorino, Carla. "Designing ultra-small nanostructured lipid carriers: critical process parameters". 2020.
    10.3390/iecp2020-08691
Journal article
  1. Mendes, Maria; Branco, Francisco; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, Carla. "A two-pronged approach against glioblastoma: drug repurposing and nanoformulation design for in situ-controlled release". Drug Delivery and Translational Research (2023): http://dx.doi.org/10.1007/s13346-023-01379-8.
    10.1007/s13346-023-01379-8
  2. Maria Mendes; JJ Sousa; Alberto Pais; Carla Vitorino. "Can Celecoxib Assay in Preclinical Studies Be Improved?". Processes (2023): https://www.mdpi.com/2227-9717/11/2/431.
    10.3390/pr11020431
  3. Zagalo, D., Silva, B., Silva, C., Simões, S. Sousa, JJ. "A quality by design (QbD) approach in pharmaceutical development of lipid-based nanosystems: A systematic review". J Drug Del Sci & Tech 70 (2022):
    Published
  4. Zagalo, D., Simões, S. Sousa, JJ. "Regulatory Science Approach in Pharmaceutical Development of Follow-On Versions of Non-Biological Complex Drug Products". J Pharm. Sci 111 10 (2022): 2687-2713.
    Published
  5. Zagalo, D., Sousa, JJ, Simões, S. "Quality by Design (QbD) Approach in Marketing Authorization Procedures of Non-Biological Complex Drugs: A Critical Evaluation". Eur J Pharm Biopharm 178 (2022): 1-24.
    Published
  6. Basso, João; Mendes, Maria; Cova, Tânia; Sousa, João; Pais, Alberto; Fortuna, Ana; Vitorino, Rui; et al. "A Stepwise Framework for the Systematic Development of Lipid Nanoparticles". Biomolecules (2022): http://hdl.handle.net/10316/103195.
    https://doi.org/10.3390/biom12020223
  7. Mendes, Maria; Basso, João; Silva, Jessica; Cova, Tânia; Sousa, João; Pais, Alberto; Vitorino, Carla. "Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: a computationally guided experimental approach". International Journal of Pharmaceutics (2020): 119661. http://dx.doi.org/10.1016/j.ijpharm.2020.119661.
    10.1016/j.ijpharm.2020.119661
  8. Maria Ferreira, João Sousa, Alberto Pais, Carla Vitorino. "The Role of Magnetic Nanoparticles in Cancer Nanotheranostics". Materials 13 (2020): 266.
  9. Vieira, I, Sousa, JJ, Vitorino, C. "Paediatric Medicines - Regulatory Drivers, Restraints, Opportunities and Challenges". J. Phar. Sci. 110 4 (2020): 1545-1556.
    Published
  10. Bouwman, ML; Sousa, JJS and Pina, MET. "Regulatory issues for orphan medicines: A review". Health Policy and Tech 9 1 (2020): 115-121.
    Published
  11. Vaz, MB; Vitorino, C and Sousa, JJS. "Safe-by-design development of a topical patch for drug delivery". Braz. J. Pharm. Sci 56 (2020):
    Published
  12. Ferreira, M; Sousa, J; (...); Vitorino, C. "The Role of Magnetic Nanoparticles in Cancer Nanotheranostics". Materials 13 2 (2020): 266.
    Published
  13. Basso, J., Mendes, M., Silva, J., Sereno, J., Cova, T., Oliveira, R., Fortuna, A., Castelo-Branco, M., Falcao, A., Sousa. "Peptide-lipid nanoconstructs act site-specifically towards glioblastoma growth impairment". Eur J Pharm Biopharm 155 (2020): 177-189.
  14. Mendes, Maria; Cova, Tânia; Basso, João; Ramos, M. Luísa; Vitorino, Rui; Sousa, João; Pais, Alberto; et al. "Hierarchical design of hyaluronic acid-peptide constructs for glioblastoma targeting: combining insights from NMR and molecular dynamics simulations". Journal of Molecular Liquids 315 (2020): http://hdl.handle.net/10773/37254.
    10.1016/j.molliq.2020.113774
  15. Ana, Raquel; Mendes, Maria; Sousa, João; Pais, Alberto; Falcão, Amílcar; Fortuna, Ana; Vitorino, Carla; et al. "Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles". International Journal of Pharmaceutics 554 (2019): 352-365. http://dx.doi.org/10.1016/j.ijpharm.2018.11.028.
    10.1016/j.ijpharm.2018.11.028
  16. João Henriques, João J. Sousa, Francisco Veiga¿, Catarina Cardoso¿, Carla Vitorino. "Process analytical technologies and injectable drug products: is there a future?". Int. J. Pharm 554 (2019): 21-35.
    Published
  17. Raquel Ana, Maria Mendes, João J. Sousa, Alberto Pais, Amilcar Falcão, Ana Fortuna, Carla Vitorino. "Rethinking polymer-lipid hybrid nanoparticles for brain delivery". Int. J. Pharm 554 (2019): 352-365.
    Published
  18. Mafalda Vaz, Carla Vitorino, João J. Sousa. "Safe-by-design development of a topical patch for drug delivery". Brazilian Journal of Pharmaceutical Sciences (2019):
    Published
  19. Jéssica Silva, João Basso, João Sousa, Ana Fortuna, Carla Vitorino. "83. Development and full validation of an HPLC methodology to quantify atorvastatin and curcumin after their intranasal co-delivery to mice". Biomedical Chromatography (2019):
    Published
  20. Gaspar, M., Pais, A, Sousa, J., Brillaut, J. Olivier, JC. "Development of levofloxacin-loaded PLGA microsphres of suitable properties for sustained pulmonary release". Int. J. Pharm 556 (2019): 117-124.
    Published
  21. Miranda, Ana; Cova, Tânia; Sousa, João; Vitorino, Carla; Pais, Alberto. "Computational modeling in glioblastoma: from the prediction of blood¿brain barrier permeability to the simulation of tumor behavior". Future Medicinal Chemistry 10 1 (2018): 121-131. http://dx.doi.org/10.4155/fmc-2017-0128.
    10.4155/fmc-2017-0128
  22. Ana Miranda, Tânia Cova, João J. Sousa, Carla Vitorino*, Alberto A. C. C. Pais. "69. Computational modelling in glioblastoma: from the prediction of BBB permeability to the simulation of tumour behaviour". Future Medicinal Chemistry 10 1 (2018): 121-131.
  23. Francisco Afonso-Pereira, Liu Dou, Sarah J Trenfield, Christine M Madla, Sudaxshina Murdan, Jõao Sousa, Francisco Veiga,. "Sex differences in the gastrointestinal tract of rats and the implications for oral drug delivery". Eur J Pharm Sci 30 115 (2018): 339-344.
    Published
  24. Maria Mendes, Ana Miranda, Tânia Cova, Lídia Goncalves, António Almeida, João J. Sousa, Maria Vale, Eduardo Marques, Alb. "Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma". Eur. J. Pharm. Sci 117 (2018): 255-269.
  25. João Basso, Ana Miranda, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Repurposing drugs for glioblastoma: From bench to bedside". Cancer Letters 428 (2018): 173-183.
    Published
  26. Jéssica Silva, Maria Mendes, Tânia Cova, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Unstructured formulation data analysis for the optimization of lipid nanoparticle drug delivery vehicles". AAPS PharmSciTech 19 5 (2018): 2383-2394.
    Published
  27. Margarida Miranda, João J. Sousa, Francisco Veiga, Catarina Cardoso, Carla Vitorino. "Bioequivalence of topical generic products. Part 1: Where are we now?". Eur. J. Pharm. Sci 123 (2018): 260-267.
    Published
  28. Margarida Miranda, João J. Sousa, Francisco Veiga, Catarina Cardoso, Carla Vitorino. "Bioequivalence of topical generic products. Part 2. Paving the way to a tailored regulatory system". Eur. J. Pharm. Sci 122 (2018): 264-272.
    Published
  29. João Basso, Ana Miranda, Sandra Nunes, Tânia Cova, João Sousa, Carla Vitorino, Alberto Pais. "Hydrogel-based drug delivery nanosystems for the treatment of brain tumors". Gels 4 (2018): 62.
  30. Sara Soares, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Nanomedicine: Principles, Properties, and Regulatory Issues". Frontiers in Chemistry 6 (2018):
  31. Maria Mendes, Sandra Nunes, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Targeted theranostic nanoparticles for brain tumor treatment". Pharmaceutics 10 4 (2018): 181.
  32. João Basso, Maria Mendes, Tânia Cova, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Analytical Quality by Design (aQbD) as a multi-addressable platform for co-encapsulating drug assays". Analytical Methods 10 47 (2018): 5659-5671.
    Published
  33. Maria Mendes, Sandra Nunes, João J. Sousa, Alberto A. C. C. Pais, Carla Vitorino. "Expanding Transdermal Delivery with Lipid Nanoparticles: A New Drug-in-NLC-in-Adhesive Design". Molecular Pharmaceutics 14 (2017): 2099-2115.
    Published
  34. Ana Miranda; María Blanco-Prieto; João J. Sousa; Alberto A. C. C. Pais; Carla Vitorino. "Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches". Int. J. Pharm., 531 1 (2017): 372-388.
    Published
  35. Ana Miranda; María Blanco-Prieto; João J. Sousa; Alberto A. C. C. Pais; Carla Vitorino. "Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles". Int. J. Pharm 531 1 (2017): 389-410.
  36. Costa, G.; Ferreira, JP; Vitorino, C; Pina, ME; Sousa, JJ; Figueiredo, IV; Batista, MT. "Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agentes". J. Ethnopharmacol 178 (2016): 222-228.
  37. Mendes, M; Soares, HT; Arnaut, LG; Sousa, JJ; Pais, AACC; Vitorino, C. "Can lipid nanoparticles improve intestinal absorption?". Int. J. Pharmac 515 1-2 (2016): 69-83.
  38. Gaspar, MC; Gregoire, N; Sousa, JJS; Pais, AACC ; Lamarche, I; Gobin, P; Olivier, JC; Marchand, S; Couet, W. "64. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres". Eur. J. Pharm. Sci 93 (2016): 184-191.
  39. Afonso-Pereira, F; Murdan, S; Sousa, J; Veiga, F; Basit, AW. "65. Sex differences in excipient effects: Enhancement in ranitidine bioavailability in the presence of polyethylene glycol in male, but not female, rats". Int. J. Pharm., 506 1-2 (2016): 237-241.
    Published
  40. Pina, M Fatima; Pinto, Joao F; Sousa, Joao J. "Generation of hydrate forms of paroxetine HCl from the amorphous state: An evaluation of thermodynamic and experimental predictive approaches.". Int. J. Pharm 481 1-2 (2015): 114-124.
    Published
  41. Simoes, M. C. F.; Sousa, J. J. S.; Pais, A. A. C. C. "Skin cancer and new treatment perspectives: A review". Cancer Letters 357 1 (2015): 8-42.
    Published
  42. Costa, G. Nunes, F.,Vitorino, C., Sousa, J., Figueiredo, I.V., and Batista, M.T. "59. Validation of a RP-HPLC Method for Quantitation of Phenolic Compounds in three Different Extracts from Cymbopogon citratus". Res. J. Medicinal Plant 9 7 (2015): 331-339.
    Published
  43. Vitorino, C., Sousa, J., Pais, A. "Overcoming the Skin Permeation Barrier: Challenges and Opportunities". Current Pharm. Design 21 20 (2015): 2698-2712.
    Published
  44. Gaspar, MC; Sousa, JJS; Pais, AACC; Cardoso, O; Murtinho, D ; Serra, MES; Tewes, F; Olivier, JC. "Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy". Eur. J. Pharm Biopharm 96 (2015): 65-75.
  45. Vitorino, Carla; Almeida, A.; Sousa, Joao. "Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies". Eur. J. Phar. Biopharm 86 2 (2014): 133-144.
    Published
  46. M. Pina, Min Zhao, João F. Pinto, João J. Sousa 1, Duncan Q.M. Craig. "An Investigation into the Dehydration Behavior of Paroxetine HCl Form I Using a Combination of Thermal and Diffraction Methods: The Identification and Characterization of a New Anhydrous Form". Crystal Growth & Design 14 8 (2014): 3774-3782.
    Published
  47. M. Pina, Min Zhao, João F. Pinto, João J. Sousa 1, Duncan Q.M. Craig. "The Influence of Drug Physical State on the Dissolution Enhancement of Solid Dispersions Prepared Via Hot-Melt Extrusion: A Case Study Using Olanzapine". J. Phar. Sci. 103 4 (2014): 1214-1223.
    Published
  48. Vitorino, C.; Almeida, A.; Sousa, J.; Lamarche, I.; Gobin, P.; Marchand, S.; Couet, W.; Olivier, J.-C.; Pais, A.. "Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: In vitro vs. in vivo studies". European Journal of Pharmaceutics and Biopharmaceutics (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84890961243&partnerID=MN8TOARS.
    10.1016/j.ejpb.2013.12.004
  49. Vitorino, C.; Alves, L.; Antunes, F.E.; Sousa, J.J.; Pais, A.A.C.C.. "Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties". Journal of Nanoparticle Research 15 10 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84887009174&partnerID=MN8TOARS.
    10.1007/s11051-013-1993-7
  50. Vueba, M.L.; Batista De Carvalho, L.A.E.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "In vitro release of ketoprofen from hydrophilic matrix tablets containing cellulose polymer mixtures". Drug Development and Industrial Pharmacy 39 11 (2013): 1651-1662. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876683639&partnerID=MN8TOARS.
    10.3109/03639045.2012.729146
  51. Vitorino, C.; Sousa, J.J.; Pais, A.A.C.C.. "A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers". Analytical Methods 5 19 (2013): 5058-5064. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884176105&partnerID=MN8TOARS.
    10.1039/c3ay40757h
  52. Gaspar, M.C.; Couet, W.; Olivier, J.-C.; Pais, A.A.C.C.; Sousa, J.J.S.. "Pseudomonas aeruginosa infection in cystic fibrosis lung disease and new perspectives of treatment: A review". European Journal of Clinical Microbiology and Infectious Diseases 32 10 (2013): 1231-1252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890559970&partnerID=MN8TOARS.
    10.1007/s10096-013-1876-y
  53. Silva, S.M.C.; Sousa, J.J.S.; Marques, E.F.; Pais, A.A.C.C.; Michniak-Kohn, B.B.. "Structure activity relationships in alkylammonium C12-Gemini surfactants used as dermal permeation enhancers". AAPS Journal 15 4 (2013): 1119-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888009099&partnerID=MN8TOARS.
    10.1208/s12248-013-9518-y
  54. Vitorino, C.; Almeida, J.; Gonçalves, L.M.; Almeida, A.J.; Sousa, J.J.; Pais, A.A.C.C.. "Co-encapsulating nanostructured lipid carriers for transdermal application: From experimental design to the molecular detail". Journal of Controlled Release 167 3 (2013): 301-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874943703&partnerID=MN8TOARS.
    10.1016/j.jconrel.2013.02.011
  55. Vueba, M.L.; Rodrigues, A.; Lourenço, P.; Batista De Carvalho, L.A.E.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Gamma scintigraphy in the analysis of ketoprofen behaviour from matrix tablets". International Journal of Pharmaceutics 448 1 (2013): 298-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876692044&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2013.03.043
  56. Roque, F.; Rama, A.C.; Sousa, J.J.; Pina, M.E.. "Development and stability assessment of liquid paediatric formulations containing sildenafil citrate". Brazilian Journal of Pharmaceutical Sciences 49 2 (2013): 381-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880960982&partnerID=MN8TOARS.
    10.1590/S1984-82502013000200021
  57. Gaspar, M., Pais, A.A.C.C, Sousa, J.J. "New Treatment Approaches of Pseudomonas aeruginosa Infection in Cystic Fibrosis Lung Disease". J. Comprehensive Pediatrics 4 4 (2013):
    Published
  58. Silva, S.M.C.; Hu, L.; Sousa, J.J.S.; Pais, A.A.C.C.; Michniak-Kohn, B.B.. "A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl". European Journal of Pharmaceutics and Biopharmaceutics 80 3 (2012): 663-673. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858159621&partnerID=MN8TOARS.
    10.1016/j.ejpb.2011.11.010
  59. Varum, F.J.O.; Veiga, F.; Sousa, J.S.; Basit, A.W.. "Mucus thickness in the gastrointestinal tract of laboratory animals". Journal of Pharmacy and Pharmacology 64 2 (2012): 218-227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855434887&partnerID=MN8TOARS.
    10.1111/j.2042-7158.2011.01399.x
  60. Silva, S.M.C.; Antunes, F.E.; Sousa, J.J.S.; Valente, A.J.M.; Pais, A.A.C.C.. "New insights on the interaction between hydroxypropylmethyl cellulose and sodium dodecyl sulfate". Carbohydrate Polymers 86 1 (2011): 35-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959345068&partnerID=MN8TOARS.
    10.1016/j.carbpol.2011.03.053
  61. Vitorino, C.; Carvalho, F.A.; Almeida, A.J.; Sousa, J.J.; Pais, A.A.C.C.. "The size of solid lipid nanoparticles: An interpretation from experimental design". Colloids and Surfaces B: Biointerfaces 84 1 (2011): 117-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951683338&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2010.12.024
  62. Varum, F.J.O.; Veiga, F.; Sousa, J.S.; Basit, A.W.. "Mucoadhesive platforms for targeted delivery to the colon". International Journal of Pharmaceutics 420 1 (2011): 11-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054695443&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2011.08.006
  63. Varum, F.J.O.; Veiga, F.; Sousa, J.S.; Basit, A.W.. "An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig". European Journal of Pharmaceutical Sciences 40 4 (2010): 335-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953536539&partnerID=MN8TOARS.
    10.1016/j.ejps.2010.04.007
  64. Costa-Balogh, F.O.; Sparr, E.; Sousa, J.J.S.; Pais, A.C.. "Drug release from lipid liquid crystalline phases: Relation with phase behavior". Drug Development and Industrial Pharmacy 36 4 (2010): 470-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749304432&partnerID=MN8TOARS.
    10.3109/03639040903261997
  65. Freire, C.; Podczeck, F.; Veiga, F.; Sousa, J.. "Influence of the coating formulation on enzymatic digestibility and drug release from 5-aminosalicylic acid pellets coated with mixtures of high-amylose starch and Surelease® intended for colon-specific drug delivery High-amylose starch-based coatings for colonic delivery". Drug Development and Industrial Pharmacy 36 2 (2010): 161-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149114692&partnerID=MN8TOARS.
    10.3109/03639040903124617
  66. Freire, C.; Podczeck, F.; Ferreira, D.; Veiga, F.; Sousa, J.; Pena, A.. "Assessment of the in-vivo drug release from pellets film-coated with a dispersion of high amylose starch and ethylcellulose for potential colon delivery". Journal of Pharmacy and Pharmacology 62 1 (2010): 55-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949530899&partnerID=MN8TOARS.
    10.1211/jpp/62.01.0005
  67. Cristina Freire, A.; Fertig, C.C.; Podczeck, F.; Veiga, F.; Sousa, J.. "Starch-based coatings for colon-specific drug delivery. Part I: The influence of heat treatment on the physico-chemical properties of high amylose maize starches". European Journal of Pharmaceutics and Biopharmaceutics 72 3 (2009): 574-586. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449152269&partnerID=MN8TOARS.
    10.1016/j.ejpb.2009.02.008
  68. Freire, C.; Podczeck, F.; Veiga, F.; Sousa, J.. "Starch-based coatings for colon-specific delivery. Part II: Physicochemical properties and in vitro drug release from high amylose maize starch films". European Journal of Pharmaceutics and Biopharmaceutics 72 3 (2009): 587-594. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449119176&partnerID=MN8TOARS.
    10.1016/j.ejpb.2009.02.010
  69. Costa-Balogh, F.O.; Sparr, E.; Sousa, J.J.S.; Pais, A.A.C.C.. "Drug release and skin permeation from lipid liquid crystalline phases". Progress in Colloid and Polymer Science 135 (2008): 119-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-62449306644&partnerID=MN8TOARS.
    10.1007/2882-2008-097
  70. Silva, S.M.C.; Pinto, F.V.; Antunes, F.E.; Miguel, M.G.; Sousa, J.J.S.; Pais, A.A.C.C.. "Aggregation and gelation in hydroxypropylmethyl cellulose aqueous solutions". Journal of Colloid and Interface Science 327 2 (2008): 333-340. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149103167&partnerID=MN8TOARS.
    10.1016/j.jcis.2008.08.056
  71. Varum, F.O.; Basit, A.W.; Sousa, J.; Veiga, F.. "Mucoadhesion studies in the gastrointestinal tract to increase oral drug bioavailability | Estudos de mucoadesão no trato gastrointestinal para o aumento da biodisponibilidade oral de fármacos". Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 44 4 (2008): 535-548. http://www.scopus.com/inward/record.url?eid=2-s2.0-59649114054&partnerID=MN8TOARS.
    10.1590/S1516-93322008000400002
  72. Silva, C.L.; Pereira, J.C.; Ramalho, A.; Pais, A.A.C.C.; Sousa, J.J.S.. "Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization". Journal of Membrane Science 320 1-2 (2008): 268-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-48549091594&partnerID=MN8TOARS.
    10.1016/j.memsci.2008.04.011
  73. Varum, F.J.O.; McConnell, E.L.; Sousa, J.J.S.; Veiga, F.; Basit, A.W.. "Mucoadhesion and the gastrointestinal tract". Critical Reviews in Therapeutic Drug Carrier Systems 25 3 (2008): 207-258. http://www.scopus.com/inward/record.url?eid=2-s2.0-43249085343&partnerID=MN8TOARS.
  74. Silva, C.L.; Topgaard, D.; Kocherbitov, V.; Sousa, J.J.S.; Pais, A.A.C.C.; Sparr, E.. "Stratum corneum hydration: Phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes". Biochimica et Biophysica Acta - Biomembranes 1768 11 (2007): 2647-2659. http://www.scopus.com/inward/record.url?eid=2-s2.0-35848966805&partnerID=MN8TOARS.
    10.1016/j.bbamem.2007.05.028
  75. Ramalho, A.; Silva, C.L.; Pais, A.A.C.C.; Sousa, J.J.S.. "In vivo friction study of human skin: Influence of moisturizers on different anatomical sites". Wear 263 7-12 SPEC. (2007): 1044-1049. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548017871&partnerID=MN8TOARS.
    10.1016/j.wear.2006.11.051
  76. Santos, H.M.M.; Sousa, J.J.M.S.. "Tablet Compression". Pharmaceutical Manufacturing Handbook: Production and Processes (2007): 1133-1163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889814085&partnerID=MN8TOARS.
    10.1002/9780470259818.ch28
  77. Santos, H.M.M.; Veiga, F.J.B.; De Pina, E.M.S.T.; De Sousa, J.J.M.S.. "Production of pellets by pharmaceutical extrusion and spheronisation. Part II. Physical characterisation of pellets | Obtenção de pellets por extrusão e esferonizaç ão farmacêutica. Parte II. Avaliação das características física de pellets". Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 42 3 (2006): 309-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845514880&partnerID=MN8TOARS.
  78. Freire, A.C.; Podczeck, F.; Sousa, J.; Veiga, F.. "Colonic drug delivery. I - The colon as a site for drug delivery | Liberação específica de fármacos para administração no cólon por via oral. I - O cólon como local de liberação de fármacos". Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 42 3 (2006): 319-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845488123&partnerID=MN8TOARS.
  79. Freire, A.C.; Podczeck, F.; Sousa, J.; Veiga, F.. "Colonic drug delivery. II - Types of delivery systems | Liberação específica de fármacos no cólon por via oral. II - Tipos de sistemas utilizados". Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 42 3 (2006): 337-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845494484&partnerID=MN8TOARS.
  80. Silva, C.L.; Nunes, S.C.C.; Eusébio, M.E.S.; Pais, A.A.C.C.; Sousa, J.J.S.. "Thermal behaviour of human stratum corneum: A differential scanning calorimetry study at high scanning rates". Skin Pharmacology and Physiology 19 3 (2006): 132-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745226219&partnerID=MN8TOARS.
    10.1159/000092593
  81. Vueba, M.L.; Batista De Carvalho, L.A.E.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Influence of cellulose ether mixtures on ibuprofen release: MC25, HPC and HPMC K100M". Pharmaceutical Development and Technology 11 2 (2006): 213-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745101434&partnerID=MN8TOARS.
    10.1080/10837450600561349
  82. Silva, C.L.; Nunes, S.C.C.; Eusébio, M.E.S.; Sousa, J.J.S.; Pais, A.A.C.C.. "Study of human stratum corneum and extracted lipids by thermomicroscopy and DSC". Chemistry and Physics of Lipids 140 1-2 (2006): 36-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645893177&partnerID=MN8TOARS.
    10.1016/j.chemphyslip.2006.01.004
  83. Vueba, M.L.; Pina, M.E.; Veiga, F.; Sousa, J.J.; De Carvalho, L.A.E.B.. "Conformational study of ketoprofen by combined DFT calculations and Raman spectroscopy". International Journal of Pharmaceutics 307 1 (2006): 56-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-28844453016&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2005.09.019
  84. Vueba, M.L.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Compatibility studies between ibuprofen or ketoprofen with cellulose ether polymer mixtures using thermal analysis". Drug Development and Industrial Pharmacy 31 10 (2005): 943-949. http://www.scopus.com/inward/record.url?eid=2-s2.0-28744440137&partnerID=MN8TOARS.
    10.1080/03639040500306153
  85. Costa-Balogh, F.O.; Åberg, C.; Sousa, J.J.S.; Sparr, E.. "Drug transport in responding lipid membranes can be regulated by an external osmotic gradient". Langmuir 21 23 (2005): 10307-10310. http://www.scopus.com/inward/record.url?eid=2-s2.0-28044459214&partnerID=MN8TOARS.
    10.1021/la051947n
  86. Vueba, M.L.; Batista De Carvalho, L.A.E.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Role of cellulose ether polymers on ibuprofen release from matrix tablets". Drug Development and Industrial Pharmacy 31 7 (2005): 653-665. http://www.scopus.com/inward/record.url?eid=2-s2.0-25144506975&partnerID=MN8TOARS.
    10.1080/03639040500216360
  87. Santos, H.; Veiga, F.; Pina, Ma.E.; Sousa, J.J.. "Compaction, compression and drug release properties of diclofenac sodium and ibuprofen pellets comprising xanthan gum as a sustained release agent". International Journal of Pharmaceutics 295 1-2 (2005): 15-27. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644380917&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2005.01.014
  88. Massaranduba Santos, H.M.; Baptista Veiga, F.J.; Tavares De Pina, M.E.; Simões De Sousa, J.J.M.. "Production of pellets by pharmaceutical extrusion and spheronisation, Part I. Evaluation of technological and formulation variables | Obtenção de pellets por extrusão e esferonizaç ão farmacêutica. Parte I. Avaliação das variáveis tecnológicas e de formulação". Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 40 4 (2004): 455-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-17244371595&partnerID=MN8TOARS.
  89. Vueba, M.L.; Batista De Carvalho, L.A.E.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets". European Journal of Pharmaceutics and Biopharmaceutics 58 1 (2004): 51-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942650441&partnerID=MN8TOARS.
    10.1016/j.ejpb.2004.03.006
  90. Costa, F.O.; Pais, A.A.C.C.; Sousa, J.J.S.. "Analysis of formulation effects in the dissolution of ibuprofen pellets". International Journal of Pharmaceutics 270 1-2 (2004): 9-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346392136&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2003.10.002
  91. Santos, H.; Veiga, F.; Pina, Ma.E.; Sousa, J.J.. "Compaction, compression and drug release characteristics of xanthan gum pellets of different compositions". European Journal of Pharmaceutical Sciences 21 2-3 (2004): 271-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742321960&partnerID=MN8TOARS.
    10.1016/j.ejps.2003.10.016
  92. Costa, F.O.; Sousa, J.J.S.; Pais, A.A.C.C.; Formosinho, S.J.. "Comparison of dissolution profiles of Ibuprofen pellets". Journal of Controlled Release 89 2 (2003): 199-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037472067&partnerID=MN8TOARS.
    10.1016/S0168-3659(03)00033-6
  93. Santos, H.; Veiga, F.; Pina, M.; Podczeck, F.; Sousa, J.. "Physical properties of chitosan pellets produced by extrusion-spheronisation: Influence of formulation variables". International Journal of Pharmaceutics 246 1-2 (2002): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037057298&partnerID=MN8TOARS.
    10.1016/S0378-5173(02)00376-9
  94. Sousa, J.J.; Sousa, A.; Moura, M.J.; Podczeck, F.; Newton, J.M.. "The influence of core materials and film coating on the drug release from coated pellets". International Journal of Pharmaceutics 233 1-2 (2002): 111-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037148652&partnerID=MN8TOARS.
    10.1016/S0378-5173(01)00921-8
  95. Sousa, J.J.; Sousa, A.; Podczeck, F.; Newton, J.M.. "Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization". International Journal of Pharmaceutics 232 1-2 (2002): 91-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037203664&partnerID=MN8TOARS.
    10.1016/S0378-5173(01)00908-5
  96. Manadas, R.; Veiga, F.; Sousa, J.J.; Pina, M.E.. "Development and validation of an HPLC method for simultaneous determination of cis- and trans-permethrin and piperonyl butoxide in pharmaceutical dosage forms". Journal of Liquid Chromatography and Related Technologies 22 12 (1999): 1867-1876. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032992319&partnerID=MN8TOARS.
    10.1081/JLC-100101772
  97. Sousa, J.J.; Sousa, A.; Newton, E.J.M.. "Produção e controlo de pellets de propranolol, HCl II. Revestimento por filme". Revista Portuguesa de Farmacia 46 1 (1996): 29-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346978262&partnerID=MN8TOARS.
  98. Sousa, J.J.; Sousa, A.; Podczeck, F.; Newton, J.M.. "Influence of process conditions on drug release from pellets". International Journal of Pharmaceutics 144 2 (1996): 159-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030606093&partnerID=MN8TOARS.
    10.1016/S0378-5173(96)04745-X
  99. Sousa, J.J.; Sousa, A.; Newton, J.M.. "Production and control of pellets of propranolol hydrochloride. I. The procurement of active pellets by means of extrusion/spheronization | PRODUCAO E CONTROLO DE PELLETS DE PROPRANOLOL, HCI. I. OBTENCAO DE PELLETS ACTIVOS POR EXTRUSAO/ESFERONIZACAO". Revista Portuguesa de Farmacia 45 2 (1995): 60-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029034376&partnerID=MN8TOARS.
Thesis / Dissertation
  1. "The influence of formulation on the formation of and drug release from film coated pellets". PhD, University College London School of Pharmacy Library, 1996.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/01 - 2022/07 Strategic and advancing regulatory science approach in pharmaceutical development in complex generic drug products
Co-supervisor
 Pharmaceutics/Regulatory (PhD)
2011/09 - 2016/07 Pulmonary targeting and biopharmaceutical evaluations of anti-infective drugs administered as innovative microsphere aerosols
Supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
2009/09 - 2014/02 Preparation and evaluation of different drug polymorphs when submitted to conventional processing technologies to produce medicines
Supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
2008/01 - 2013/05 Skin permeation, permeation enhancers and transdermal devices: pharmaceutical development and in vivo approach
Supervisor
 Pharmaceutics (PhD)
2006/10 - 2013/04 Strategies for development of transdermal devices: from enhancing effect to final formulations
Supervisor
 Pharmaceutics
2006/10 - 2012/04 Colonic mucoadhesion: a potential approach to increase residence time and drug bioavailability in the human colon
Co-supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
2003/03 - 2010/10 Drug delivery involving polymeric materials: The chemical characterization of polymer/drug complexes in transdermal devices
Supervisor
 Pharmaceutics (PhD)
2004/10 - 2009/10 Libertação de fármacos no cólon: optimização de formulações contendo fármacos usados no tratamento de doenças específicas do cólon
Co-supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
2004/01 - 2007/11 Studies on permeation for transdermal delivery
Supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
2000/12 - 2006/10 Comprimidos matriciais na libertação modificada de fármacos
Co-supervisor
 Pharmaceutics (PhD)
Universidade de Coimbra, Portugal
1998/11 - 2004/07 Design e avaliação in vitro/in vivo de pellets matriciais de libertação controlada
Supervisor
Universidade de Coimbra, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/03 Nanostructured systems containing Passiflora edulis extract: A new dermocosmetic alternative as skin antioxidant and depigmentant
(Thesis) Main arguer
 Karolline Krambeck (PhD)
Universidade do Porto, Portugal
2020/09 Dual-purpose oromucosal films and tablets for the local management of oral mucositis
(Thesis) Main arguer
 João Costa Campos (PhD)
Universidade do Porto, Portugal
2020/03 Cyclodextrins as excipientes in solid oral dosage forms
(Thesis) Main arguer
 Jaime Manuel Guedes Morais da Conceição (PhD)
2019/05 Unveiling novel anticancer drugs activity through biophysical studies: applications in drug delivery systems
(Thesis) Main arguer
 José Plácido Lopes de Araújo (PhD)
Universidade do Porto, Portugal
2018/01 Layer-by-layer nanoparticles designed to improve the bioavailability of resveratrol
(Thesis) Arguer
 Ana Cláudia Paiva Santos (PhD)
2017/11 Nanocarriers as alternative strategies for treatment of mycobacterial infections
(Thesis) Main arguer
 Alexandre Couto Carneiro Vieira (PhD)
Universidade do Porto, Portugal
2017/09 Lipid-based nanostrategies for fight Helicobacter pylori gastric infection
(Thesis) Main arguer
 Catarina Leal Seabra (PhD)
Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal
2017/06 Efeito de nanopartículas à base de biopolímeros no aumento da permeação de insulina através do epitélio intestinal
(Thesis) Arguer
 Marlene Almeida Lopes Marques (PhD)
Universidade de Coimbra, Portugal
2016/05 Development of personal care products with active ingredients obtained from natural products without added value
(Thesis) Main arguer
 Francisca Pinto Lisboa Martins Rodrigues Sarmento (PhD)
Universidade do Porto, Portugal
2016/01 Nose-to-brain delivery of Lacosamide, Levetriracetam and Zonisamide and the impact of BCRP efflux: an in vitro/in vivo approach
(Thesis) Arguer
 Ana Isabel Azevedo Serralheiro (PhD)
Universidade de Coimbra, Portugal
2015/07 Production of laminar extrudates containing particles of a model drug processed by supercritical fluids
(Thesis) Main arguer
 Gonçalo Emanuel Rodrigues da Cunha Correia de Oliveira (PhD)
Universidade de Lisboa, Portugal
2015/06 Self-Assembled polymeric micelles as powders for pulmonary administratin of insulin
(Thesis) Main arguer
 Fernanda Raquel da Silva Andrade (PhD)
Universidade do Porto, Portugal
2015/04 Introdução dos antibióticos em Portugal: Ciência, técnica e sociedade (anos 40 a 60 do século Z«XX). Estudo de caso da penicilina
(Thesis) Arguer
 Victoria Bell (PhD)
Universidade de Coimbra, Portugal
2014/12 Nanotecnologia aplicada a formulações tópicas de fármacos anti-inflamatórios não esteróides
(Thesis) Main arguer
 Giuliana Mancini (PhD)
Universidade de Lisboa, Portugal
2014/09 Synthesis of diclofenac-cyclodextrin conjugates for colon delivery
(Thesis) Arguer
 Amélia Catarina Fernandes Soares Vieira (PhD)
Universidade de Coimbra, Portugal
2014/09 Poliesteramidashiperramiicadas como portadores en sistemas microparticulares matriciales de libéracion de fármacos elaborados mediante extrusion por fusión
(Thesis) Main arguer
 Elena Raivin Eirin (PhD)
Universidade de Santiago de Compostela, Spain
2013/10 Lipid nanoparticles and permeation enhancement for transdermal drug delivery
Supervisor
 Carla Sofia Pinheiro Vitorino (PhD)
Universidade de Coimbra, Portugal
2013/09 Pharmaceutical topical dosage forms as carriers for glucocorticoids
(Thesis) Main arguer
 Sara Sofia Caliço Raposo (PhD)
Universidade de Lisboa, Portugal
2013/06 Calcium alginate nanoparticles as biomacromelecule delivery systems – DNA as a model biomacromolecule
(Thesis) Arguer
 Alexandra Henriques Encarnação Machado (PhD)
Universidade de Coimbra, Portugal
2013/06 Supramolecular cyclodextrin gels for treatment of osteomyelitis and bone regeneration
(Thesis) Arguer
 Susana Margarida Neto Simões (PhD)
Universidade de Coimbra, Portugal
2012/07 Mucus and mucoadhesion in the gastrointestinal tract
(Thesis) Arguer
 Felipe José oliveira Varum (PhD)
Universidade de Coimbra, Portugal
2012/03/09 Evaluación de algunas aproximaciones tecnológicas para incrementar la velocidad de disolución de fármaco en pellets de celulosa microcristalina
(Thesis) Main arguer
 Álvaro Goyanes Goyanes (PhD)
Universidade de Santiago de Compostela, Spain
2012/02 Modelação da cedência de zidovudina a partir de comprimidos matriciais. Influência da mistura de polímeros celulósicos e acrílicos
(Thesis) Arguer
 Jucimary Vieira dos Santos (PhD)
Universidade de Coimbra, Portugal
2011/07 Diffusion studies: from model membranes to transdermal devices
Supervisor
 Maria de Fátima Faria de Oliveira e Costa Balogh (PhD)
Universidade de Coimbra, Portugal
2011/07 Oral delivery of bioactive insulin through design and development of a polymeric nanoparticulate carrier
(Thesis) Arguer
 Camile Baldin Woitisski (PhD)
Universidade de Coimbra, Portugal
2011/06 Profiling the control of hepatic glucose and lipid metabolism for evaluating novel strategies of insulin delivery
(Thesis) Arguer
 Ana Francisca Leal Silva Soares (PhD)
Universidade de Coimbra, Portugal
2010/05 Evaluation of the viability of Lactobacillus spp. in diferente dosage forms
(Thesis) Main arguer
 Mariya Ivanova Brachkova (PhD)
Universidade de Lisboa, Portugal
2009/06 Strategies to improve omeprazole solubility and permeability
(Thesis) Arguer
 Ana Rita Ramalho Figueiras (PhD)
Universidade de Coimbra, Portugal
2008/04/23 Skin structure and drug permeation
Supervisor
 Cláudia Liliana de Bastos Sousa Silva (PhD)
Universidade de Coimbra, Portugal
2008/03/31 Estudo da dispersão e deposição de aerossoles medicamentosos gerados por inaladores de pó seco
(Thesis) Main arguer
 Pedro Augusto de Morais Sarmento Jorge Mendes (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2008/02 Encapsulação de fármacos peptídicos pelo método de emulsificação/gelificação interna
(Thesis) Arguer
 Ana Catarina Beco Pinto Reis (PhD)
Universidade de Coimbra, Portugal
2007/04 Aumento da biodisponibilidade oral de fármacos peptídicos recorrendo à encapsulação com alginato e quitosano
Thesis Member
 Catarina Isabel de Bulhão Pato Mendes da Silva (PhD)
Universidade de Coimbra, Portugal
2006/11 Comprimidos matriciais na libertação modificada de fármacos
Supervisor
 Manuel Londa Vueba (PhD)
Universidade de Coimbra, Portugal
2005/07/01 Design e avaliação in vitro/in vivo de pellets matriciais de libertação controlada
Supervisor
 Helton Max Massaradunda Santos (PhD)
Universidade de Coimbra, Portugal
2005/07 Sistemas multicomponentes com ciclodextrinas como estratégia para optimizar a biodisponibilidade oral de fármacos – aplicação em medicamentos de libertação prolongada
Thesis Member
 Laura Sofia dos Santos Ribeiro (PhD)
Universidade de Coimbra, Portugal
2003/07 As ciclodextrinas como agentes modeladores da libertação de fármacos – nova estratégia para medicamentos de libertação prolongada
Thesis Member
 Catarina Cabral Marques Fernandes (PhD)
Universidade de Coimbra, Portugal
1999/10/04 Evaluación de pelets recubiertos de etilcelulosa/pectinas como sistemas de liberación colónica de triamcinolona
(Thesis) Main arguer
 Elena Villar Lopez (PhD)
Universidade de Santiago de Compostela, Spain
1999/09 Polimorfismo de compostos orgânicos: polimorfos de terfenadina
Thesis Member
 João Carlos Canotilho Lage (PhD)
Universidade de Coimbra, Portugal

Consulting

Activity description Institution / Organization
1998/07 - Current Quality Expert EMA- European Medical Agency, Netherlands
1997/01 - Current Quality Expert - Comissão de Avaliação de Medicamentos, Infarmed, IP Infarmed, IP, Portugal
Distinctions

Award

1985 Prémio Sociedade Farmacêutica Lusitana
Ordem dos Farmaceuticos, Portugal