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Francisca Isabel Alves da Silva Carvalhal completed the Master in Pharmaceutical Chemistry in 2017/09/07 at Universidade do Porto Faculdade de Farmácia and the Bachelor in Biochemistry in 2015/09/16 at Universidade do Porto Faculdade de Ciências. Attends the PhD in Pharmaceutical Sciences at Universidade do Porto Faculdade de Farmácia. Francisca is a Research Collaborator at Universidade do Porto/ Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR). She is part of a StartUP project and was part of three projects, two Research fellow at CIIMAR within a FCT­funded project (PTDC/AAGTEC/0739/2014) and a Research Intership at Harvard Medical School within a FLAD call 2018 R&D@PhD internship grant – USA. Published three papers in high impact factor journals (average 4.16 impact factor) and Presented >10 communications in National and International conferences, one of which awarded as "Best Poster". Works in the areas of Exact and Natural Sciences, more specifically on Chemical Sciences with emphasis on Organic Chemistry and on Biological Sciences with emphasis on Marine Biology. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: Synthesis; Sulfated small-molecules; Antifouling.
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Identification

Personal identification

Full name
Francisca Isabel Alves da Silva Carvalhal

Citation names

  • Carvalhal, Francisca

Author identifiers

Ciência ID
2413-955C-45CE
ORCID iD
0000-0002-4546-623X

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Natural sciences - Biological Sciences - Marine Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2018/09/13 - 2023
Ongoing
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/07
Concluded
 Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Synthesis and antifouling evaluation of nature-inspired compounds (classification 18 out of 20)" (THESIS/DISSERTATION)
 16
2015/09/16
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Caracterização molecular dos S2-, S5-, S10- e S25-haplótipos dos genes SFBB2, SFBB5, SFBB6, SFBB14 e SFBB16 em Malus (classification 19 out of 20) " (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2016/09/15 - Current Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2018/09/13 - Current PhD Student Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2019/06/01 - 2019/09/30 Research Internship Harvard Medical School, United States
National Center for Functional Glycomics, United States
(...)
2018 - 2019 Fellowship Researcher Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2014/02/01 - 2014/07/31 Internship "Programa de Estágios Extra-Curriculares da FCUP (PEEC). Avaliação da ecotoxicidade de nanopartículas de óxidos metálico." Grade 5 out of 5. Universidade do Porto Faculdade de Ciências, Portugal
Projects

Grant

Designation Funders
2020/02/01 - 2021/12/31 Startup project - SuitChem
1044
Other
Instituto de Apoio às Pequenas e Médias Empresas e à Inovação (IAPMEI) , Portugal
 Instituto de Apoio às Pequenas e Médias Empresas e à Inovação (IAPMEI)
Ongoing
2019/06/01 - 2019/09/30 Investigate new biological screening process for Zika virus and explore possible treatments
Proj. 2/2019
Research Fellow
Harvard Medical School, United States

Beth Israel Deaconess Medical Center, United States

National Center for Functional Glycomics, United States
Fundação Luso-Americana
Concluded
2018/11/15 - 2019/05/15 Overcoming environmental problems associated with antifouling agents: Synthesis of Nature-inspired non-toxic biocides and immobilization in polymeric coatings.
PTDC/AAG-TEC/0739/2014 e POCI-01-0145-FEDER-016793 (Referência da Bolsa PTDC/AAG-TEC/0739/2014-BI-2017-063)
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2017/12/01 - 2018/06/30 Overcoming environmental problems associated with antifouling agents: Synthesis of Nature-inspired non-toxic biocides and immobilization in polymeric coatings.
PTDC/AAG-TEC/0739/2014 e POCI-01-0145-FEDER-016793 (Referência da bolsa PTDC/AAG-TEC/0739/2014-BI-2017-018)
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded

Other

Designation Funders
2020/10/01 - Current ATLANTIDA - Platform for the monitoring of the North Atlantic Ocean and tools for the sustainable exploitation of the marine resources
NORTE-01-0145-FEDER-000040
Researcher
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
Outputs

Publications

Conference abstract
  1. Pinheiro, S.; Carvalhal, Francisca; Neves, A.R; Sousa, E.; Pinto, M.; Afonso, C.M.; Correia da Silva, M.. "Improving synthetic procedures through green chemistry methodologies for obtaining new antifouling agents.". Paper presented in 2ª Edição do Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto, Porto, 2020.
    Published
  2. Carvalhal, Francisca; Neves, Ana; Câmara, Amadeu; Sousa, Emília; Pinto, Madalena; Correia-da-Silva, Marta. "Biologically-active sulfated steroids: synthesis and state-of-art". 2018.
    Published • 10.3390/ecmc-4-05574
Conference poster
  1. Carvalhal, Francisca; Palmeira, A.; Neves, A.R.; Pinto, M.; Sousa, E.; Correia-da-Silva, M.. "Virtual Screening of Synthetic Compounds Potential Inhibitors of Envelope Protein of Zika Virus". Paper presented in Blue Think Conference, 2020.
  2. Vilas-Boas, Cátia; Carvalhal, Francisca; Cravo, S.; Sousa, E.; Pinto, M.; Silva, E. R.; Correia-da-Silva, M.. "Immobilization of a new eco-friendly antifouling agent in commercial marine coatings.". Paper presented in BIOPROSP_19: International Conference on Marine Bioprospecting and Biotechnology, 2019.
  3. Carvalhal, Francisca; Neves, A. R.; Gonçalves, C.; Almeida, J.; Sousa, E.; Vasconcelos, V.; Pinto, M.; Correia-da-Silva, M.. "Methyl deoxycholate monosulfate, a new antifouling compound with low bioaccumulative potential.". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  4. Carvalhal, Francisca; Vilas-Boas, C., Cravo, S.; Sousa, E.; Pinto, M.; Silva, E. R.; Correia-da-Silva, M.. "Synthetic improvements of a new antifouling agent and its application in marine coatings". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  5. Carvalhal, Francisca; Correia-da-Silva, M.; Sousa, E.; Pinto, M.. "Synthesis of 3-(2,3,4,6-tetra-sulfate-O-ß-D-glucopyranosyl)xanthone: a potential new anticoagulant compound". Paper presented in 3rd Edition of the Winter School of Pharmacy, 2018.
  6. Carvalhal, Francisca; Almeida, J.; Sousa, E.; Fernandes, C.; Vasconcelos, V.; Pinto, M.; Correia-da-Silva, M.. "Synthesis of new bioinspired antifouling agents". Paper presented in 12th National Meeting of Organic Chemistry / 5th National Meeting of Therapeutic Chemistry, 2018.
  7. Carvalhal, Francisca; Sousa, E.; Neves, A. R.; Correia-da-Silva, M.; Pinto, M.. "Synthesis and structural elucidation of 3,4-dihydroxyxanthone derivatives". Paper presented in 10º Meeting of Young Researchers of University of Porto (IJUP17), 2017.
  8. Carvalhal, Francisca; Sousa, E.; Neves, A. R.; Correia-da-Silva, M.; Pinto, M.. "Synthesis of 3,4-dihydroxyxanthone derivatives: hit optimization". Paper presented in 2nd Edition of the Winter School of Pharmacy, 2017.
Journal article
  1. Vilas-Boas, Cátia; Neves, Ana Rita; Carvalhal, Francisca; Pereira, Sandra; Calhorda, Maria José; Vasconcelos, Vitor; Pinto, Madalena; et al. "Multidimensional characterization of a new antifouling xanthone: Structure-activity relationship, environmental compatibility, and immobilization in marine coatings". Ecotoxicology and Environmental Safety 228 (2021): 112970. http://dx.doi.org/10.1016/j.ecoenv.2021.112970.
    Published • 10.1016/j.ecoenv.2021.112970
  2. Neves, Ana R.; Almeida, Joana R.; Carvalhal, Francisca; Câmara, Amadeu; Pereira, Sandra; Antunes, Jorge; Vasconcelos, Vitor; et al. "Overcoming environmental problems of biocides: Synthetic bile acid derivatives as a sustainable alternative". Ecotoxicology and Environmental Safety 187 (2020): 109812. http://dx.doi.org/10.1016/j.ecoenv.2019.109812.
    Published • 10.1016/j.ecoenv.2019.109812
  3. Carvalhal, Francisca; Cristelo, Ricardo; Resende, Diana; Pinto, Madalena; Sousa, Emília; Correia-da-Silva, Marta. "Antithrombotics from the Sea: Polysaccharides and Beyond". Marine Drugs 17 3 (2019): 170. http://dx.doi.org/10.3390/md17030170.
    Published • 10.3390/md17030170
  4. Carvalhal, Francisca; Correia-da-Silva, Marta; Sousa, Emília; Pinto, Madalena; Kijjoa, Anake. "SULFATION PATHWAYS: Sources and biological activities of marine sulfated steroids". Journal of Molecular Endocrinology 61 2 (2018): T211-T231. http://dx.doi.org/10.1530/jme-17-0252.
    Published • 10.1530/jme-17-0252
Thesis / Dissertation
  1. Carvalhal, Francisca. "Synthesis and Antifouling Evaluation of Nature-Inspired Compounds". Master, Universidade do Porto Faculdade de Farmácia, 2017.
  2. Carvalhal, Francisca. "Caracterização molecular dos S2-, S5-, S10- e S25-haplótipos dos genes SFBB2, SFBB5, SFBB6, SFBB14 e SFBB16 em Malus". Degree, Universidade do Porto Faculdade de Ciências, 2015.

Other

Other output
  1. Bioprospecting the marine world for the search of new antithrombotic alternatives. Seminar within the scope of the PhD in Pharmaceutical Sciences, Faculty of Pharmacy of the University of Porto. 2019. Carvalhal, Francisca.
  2. Marine Sulfated Steroids. Seminar within the scope of the MSc in Pharmaceutical Chemistry, Faculty of Pharmacy of the University of Porto. 2016. Carvalhal, Francisca.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/01/15 Helping Mother Nature through Medicinal Chemistry in lato sensu: new Nature-inspired antifouling compounds obtained by synthesis. 13º Encontro Nacional de Química Orgânica / 6º Encontro Nacional de Química Terapêutica,
(Aveiro, Portugal)
2018/02/07 Fighting marine macrofouling: synthesis and in vivo evaluation of new antifoulants 11º Meeting of Young Researchers of University of Porto (IJUP18)
(Porto, Portugal)
2016/07/19 Marine Sulfated Steroids. Summer curse – Pharmaceutical Drugs: How to obtain, how do they work and why (a perspective in pharmaceutical medicinal chemistry)
Universidade do Porto Faculdade de Farmácia (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2018/09/15 - 2018/09/15 CIIMAR Open Day. Leixões Cruise Terminal and CIIMAR open to the public to celebrate the “Dia do Porto de Leixões”. The program included scientific experiments and exhibitions of the work of CIIMAR researchers. (2018/09/15)
Exhibition (Co-organisor)
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2020/04/03 - 2020/04/03 Webinar focused on the current COVID-19 pandemic. Explore strategies and tools to help thrive in this new environment that we all find ourselves.
Seminar
 Chemists Fighting COVID-19: Tools to Thrive Remotely
European Young Chemist's Network, Belgium
2020/04/02 - 2020/04/02 Webinar focused around the current COVID-19 pandemic. Explore the current understanding of COVID-19 and hear from speakers around the world about the impact that the pandemic is having in their region.
Seminar
 Chemists Fighting COVID-19: The Status Quo
European Young Chemist's Network, Belgium
2020/03/29 - 2020/03/29 Online formation in chromatography - Introduction to Gas chromatography (GC). Speaker Rafael Chust. Duration 2 hours.
Seminar
 Introdução à GC
2020/03/27 - 2020/03/27 Online formation in chromatography - Introduction to High performance liquid chromatography (HPLC). Speaker Rafael Chust. Duration 2 hours.
Seminar
 Introdução à HPLC
2020/03/12 - 2020/03/12 Webinar - HRMS strategies for (un)targeted screening of printing inks in extractable studies.
Seminar
 High Resolution Mass Spectrometry (HRMS) strategies for targeted and untargeted screening of printing inks in extractable studies.
Waters UK, United Kingdom
2020/02/12 - 2020/02/14 Meeting of students from University of Porto, with oral and poster presentations, within the scope of different research areas.
Conference
 13º Meeting of Young Researchers of University of Porto (IJUP20)
Universidade do Porto, Portugal
2019/11/20 - 2019/11/20 Webinar - Introduction to EndNote X9 Web of Science Group. Part of the Research. Smarter. Training series: helping you power through every stage of your research journey.
Seminar
 Introduction to EndNote X9
2019/10/15 - 2019/10/15 Webinar - Back to basics: Column characterization.
Seminar
 Back to basics: Caracterização de colunas. Capítulo 1
Waters UK, Portugal
2019/09/19 - 2019/09/19 Attendee at the day-long symposium focused on the cutting edge research in Chemical Biology
Symposium
 Third Annual "Chemical Biology in the HUB"
Merck Research Laboratories Boston, United States
2018/10/24 - 2018/10/24 Training action of Web of Science and Scopus: searching in citation databases Web of Science e Scopus: pesquisa em bases de dados de citações
Universidade do Porto Faculdade de Farmácia, Portugal
2018/10/01 - 2018/10/02 Attendance at the LABTALKS - 1st Laboratory Security Conference
Seminar
 LABTALKS - 1st Laboratory Security Conference
Universidade do Porto Porto Business School, Portugal
2017/06/27 - 2017/06/29 Poster session promotion "Synthesis and structural elucidation of 3,4-dihydroxyxanthone derivatives"
Other
 Summer curse – Pharmaceutical Drugs: How to obtain, how do they work and why (a perspective in pharmaceutical medicinal chemistry)
Universidade do Porto Faculdade de Farmácia, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/02/23 - 2018/02/23 Course unit Bioensaios na Descoberta de Fármacos of the MSc in Pharmaceutical Chemisty 2017/2018 (1 hour) "In vivo anti-settlement activity of Mytilus galloprovinciallis larvae: screening of antifouling activity of new compounds" Química Farmacêutica (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal

Other jury / evaluation

Activity description Institution / Organization
2020/12/17 - 2020/12/17 Invited jury to evaluate panel communications developed and presented by students of the MSc in Pharmaceutical Sciences, at the Jornadas Pedagógico-Científicas Madalena Pinto'19 Universidade do Porto Faculdade de Farmácia/ Laboratório de Química Orgânica e Farmacêutica, Portugal
2019/11/21 - 2019/11/21 Invited jury to evaluate panel communications developed and presented by students of the MSc in Pharmaceutical Sciences, at the Jornadas Pedagógico-Científicas Madalena Pinto¿19 Universidade do Porto Faculdade de Farmácia/ Laboratório de Química Orgânica e Farmacêutica, Portugal
2019/01/07 - 2019/01/07 Jury of the report and presentation developed by the MSc student Joana teixeira "Síntese e elucidação estrutural de um seletor quiral de natureza xantónica. Avaliação da eficiência de uma coluna quiral para cromatografia líquida.", within the Curricular Unit Planeamento e obtenção de substâncias ativas of the Master in Pharmaceutical Chemistry, FFUP. Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Award

2019 Best Poster Award "Immobilization of a new eco-friendly antifouling agent in commercial marine coatings."

Other distinction

2018 Grant for an internship at Harvard Medical School
Fundação Luso-Americana, Portugal